Metformin

• 

  Subject Areas on Research

  • A quantitative measure of diabetes risk in community practice impacts clinical decisions: the PREVAIL initiative. 
  • A retrospective cohort study of economic outcomes and adherence to monotherapy with metformin, pioglitazone, or a sulfonylurea among patients with type 2 diabetes mellitus in the United States from 2003 to 2005. 
  • Altering hirsutism through ovulation induction in women with polycystic ovary syndrome. 
  • Antidiabetic therapies affect risk of pancreatic cancer. 
  • Association of diabetes duration and diabetes treatment with the risk of hepatocellular carcinoma. 
  • Association of diabetes mellitus and glycemic control strategies with clinical outcomes after acute coronary syndromes. 
  • Baseline factors associated with glycaemic response to treatment with once-weekly dulaglutide in patients with type 2 diabetes. 
  • CCAAT/enhancer-binding protein beta deletion reduces adiposity, hepatic steatosis, and diabetes in Lepr(db/db) mice. 
  • Capitalizing on prescribing pattern variation to compare medications for type 2 diabetes. 
  • Capsule Commentary on Min et al., Comparative Effectiveness of Insulin versus Combination Sulfonylurea and Insulin: a Cohort Study of Veterans with Type 2 Diabetes: How to Escalate Therapy for Patients who Fail Sulfonylureas. 
  • Cardiovascular and renal safety of metformin in patients with diabetes and moderate or severe chronic kidney disease: Observations from the EXSCEL and SAVOR-TIMI 53 cardiovascular outcomes trials. 
  • Clinical Outcomes With Metformin and Sulfonylurea Therapies Among Patients With Heart Failure and Diabetes. 
  • Clinical Outcomes of Metformin Use in Populations With Chronic Kidney Disease, Congestive Heart Failure, or Chronic Liver Disease: A Systematic Review. 
  • Clinical correlates of histopathology in pediatric nonalcoholic steatohepatitis. 
  • Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome. 
  • Comparing the effects of ipragliflozin versus metformin on visceral fat reduction and metabolic dysfunction in Japanese patients with type 2 diabetes treated with sitagliptin: A prospective, multicentre, open-label, blinded-endpoint, randomized controlled study (PRIME-V study). 
  • Comparison of insulin glargine and liraglutide added to oral agents in patients with poorly controlled type 2 diabetes. 
  • Cost-effectiveness of diabetes treatment sequences to inform step therapy policies. 
  • Current practices in gestational diabetes mellitus diagnosis and management in the United States: survey of maternal-fetal medicine specialists. 
  • Diabetes medication regimens and patient clinical characteristics in the national patient-centered clinical research network, PCORnet. 
  • Differential AMPK phosphorylation by glucagon and metformin regulates insulin signaling in human hepatic cells. 
  • Early atherosclerosis is associated with retinal microvascular changes in adolescents with type 1 diabetes. 
  • Editor's Highlight: Metformin Protects Against Acetaminophen Hepatotoxicity by Attenuation of Mitochondrial Oxidant Stress and Dysfunction. 
  • Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial. 
  • Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism. 
  • Effects of Liraglutide on Cardiovascular Outcomes in Type 2 Diabetes Patients With and Without Baseline Metformin Use: Post Hoc Analyses of the LEADER Trial. 
  • Effects of ipragliflozin versus metformin in combination with sitagliptin on bone and muscle in Japanese patients with type 2 diabetes mellitus: Subanalysis of a prospective, randomized, controlled study (PRIME-V study). 
  • Efficacy and Safety of the Glucagon Receptor Antagonist RVT-1502 in Type 2 Diabetes Uncontrolled on Metformin Monotherapy: A 12-Week Dose-Ranging Study. 
  • Efficacy and safety of acarbose in metformin-treated patients with type 2 diabetes. 
  • Efficacy of metformin and fermentable fiber combination therapy in adolescents with severe obesity and insulin resistance: study protocol for a double-blind randomized controlled trial. 
  • Endometrial shedding effect on conception and live birth in women with polycystic ovary syndrome. 
  • Estimating live birth rates after ovulation induction in polycystic ovary syndrome: sample size calculations for the pregnancy in polycystic ovary syndrome trial. 
  • Extended-release metformin does not reduce the clomiphene citrate dose required to induce ovulation in polycystic ovary syndrome. 
  • Genetic Variants in CPA6 and PRPF31 Are Associated With Variation in Response to Metformin in Individuals With Type 2 Diabetes. 
  • Glucose and lipid effects of the ileal apical sodium-dependent bile acid transporter inhibitor GSK2330672: double-blind randomized trials with type 2 diabetes subjects taking metformin. 
  • Glycemic Control and Insulin Treatment Alter Fracture Risk in Older Men With Type 2 Diabetes Mellitus. 
  • Gut hormone pharmacology of a novel GPR119 agonist (GSK1292263), metformin, and sitagliptin in type 2 diabetes mellitus: results from two randomized studies. 
  • Impact of metformin use on the cardiovascular effects of dipeptidyl peptidase-4 inhibitors: An analysis of Medicare claims data from 2007 to 2015. 
  • Intercourse compliance, ovulation, and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome (PPCOS) Trial. 
  • LKB1 and mammalian target of rapamycin as predictive factors for the anticancer efficacy of metformin. 
  • Liver dysfunction in paediatric obesity: a randomized, controlled trial of metformin. 
  • Management of newly treated diabetes in Medicare beneficiaries with and without heart failure. 
  • Medication adherence and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome Trial. 
  • Metabolic syndrome: evaluation of pathological and therapeutic outcomes. 
  • Metformin Targets Central Carbon Metabolism and Reveals Mitochondrial Requirements in Human Cancers. 
  • Metformin Use Is Associated with Improved Survival in Patients Undergoing Resection for Pancreatic Cancer. 
  • Metformin Use May Moderate the Effect of DPP-4 Inhibitors on Cardiovascular Outcomes. 
  • Metformin and/or clomiphene do not adversely affect liver or renal function in women with polycystic ovary syndrome. 
  • Metformin does not affect risk of biochemical recurrence following radical prostatectomy: results from the SEARCH database. 
  • Metformin for weight loss and metabolic control in overweight outpatients with schizophrenia and schizoaffective disorder. 
  • Metformin in the treatment of non-alcoholic steatohepatitis: a pilot open label trial. 
  • Metformin is associated with improved survival in endometrial cancer. 
  • Metformin prevents tobacco carcinogen--induced lung tumorigenesis. 
  • Metformin reverses fatty liver disease in obese, leptin-deficient mice. 
  • Metformin use and risk of prostate cancer: results from the REDUCE study. 
  • Metformin use in patients hospitalized with COVID-19: lower inflammation, oxidative stress, and thrombotic risk markers and better clinical outcomes. 
  • Metformin use is associated with better survival of diabetic patients with pancreatic cancer. 
  • Metformin, Diabetes, and Survival among U.S. Veterans with Colorectal Cancer-Response. 
  • Metformin, Diabetes, and Survival among U.S. Veterans with Colorectal Cancer. 
  • Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner. 
  • Monocarboxylate transporter antagonism reveals metabolic vulnerabilities of viral-driven lymphomas. 
  • New combination treatments in the management of diabetes: focus on sitagliptin-metformin. 
  • New strategies in pancreatic cancer: emerging epidemiologic and therapeutic concepts. 
  • Obesity and altered angiogenic-related gene expression in endometrial cancer. 
  • One-year sustained glycemic control and weight reduction in type 2 diabetes after addition of liraglutide to metformin followed by insulin detemir according to HbA1c target. 
  • Outpatient metformin use is associated with reduced severity of COVID-19 disease in adults with overweight or obesity. 
  • Ovulatory response to treatment of polycystic ovary syndrome is associated with a polymorphism in the STK11 gene. 
  • Patient-reported outcomes in patients with type 2 diabetes treated with liraglutide or glimepiride, both as add-on to metformin. 
  • Pharmacologic Treatment of Diabetes in Pregnancy. 
  • Plasma levels of DPP4 activity and sDPP4 are dissociated from inflammation in mice and humans. 
  • Rationale, design, and organization of a randomized, controlled Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS) in patients with type 2 diabetes and established cardiovascular disease. 
  • Recombinant glucagon-like peptide-1 (7-36 amide) lowers fasting serum glucose in a broad spectrum of patients with type 2 diabetes. 
  • Reply: Revisited Metformin Therapy in Heart Failure With Preserved Ejection Fraction. 
  • Repositioning metformin for cancer prevention and treatment. 
  • Respiratory Capacity and Reserve Predict Cell Sensitivity to Mitochondria Inhibitors: Mechanism-Based Markers to Identify Metformin-Responsive Cancers. 
  • SPHK1 Is a Novel Target of Metformin in Ovarian Cancer. 
  • Safety events in kidney transplant recipients: results from the folic Acid for vascular outcome reduction in transplant trial. 
  • Sequential intensification of metformin treatment in type 2 diabetes with liraglutide followed by randomized addition of basal insulin prompted by A1C targets. 
  • Sitagliptin and risk of fractures in type 2 diabetes: Results from the TECOS trial. 
  • Statin and metformin use and outcomes in patients with castration-resistant prostate cancer treated with enzalutamide: A meta-analysis of AFFIRM, PREVAIL and PROSPER. 
  • Statins are Associated With Increased Biochemical Recurrence After Radical Prostatectomy in Diabetic Men but no Association was Seen in Men also Taking Metformin: Results From the SEARCH Database. 
  • Targeted Multiplex Gene Expression Profiling to Measure High-Fat Diet and Metformin Effects on Fetal Gene Expression in a Mouse Model. 
  • Targeting T-cell oxidative metabolism to improve influenza survival in a mouse model of obesity. 
  • The Pregnancy in Polycystic Ovary Syndrome study: baseline characteristics of the randomized cohort including racial effects. 
  • The clinical treatment of childhood obesity. 
  • The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. 
  • The effects of metformin on body mass index and glucose tolerance in obese adolescents with fasting hyperinsulinemia and a family history of type 2 diabetes. 
  • Treatment of diabetes mellitus: implications of the use of oral agents. 
  • Treatment of nonalcoholic fatty liver disease in children: TONIC trial design. 
  • Treatment with incretins does not increase the risk of pancreatic diseases compared to older anti-hyperglycaemic drugs, when added to metformin: real world evidence in people with Type 2 diabetes.