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Subject Areas on Research
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A Mets motif peptide found in copper transport proteins selectively binds Cu(I) with methionine-only coordination.
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A comparison of methionine, histidine and cysteine in copper(I)-binding peptides reveals differences relevant to copper uptake by organisms in diverse environments.
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A gain-of-function polymorphism controlling complex traits and fitness in nature.
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A gene controlling variation in Arabidopsis glucosinolate composition is part of the methionine chain elongation pathway.
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A mathematical model gives insights into nutritional and genetic aspects of folate-mediated one-carbon metabolism.
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A mathematical model of the folate cycle: new insights into folate homeostasis.
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A mathematical model of the methionine cycle.
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A mathematical modelling approach to assessing the reliability of biomarkers of glutathione metabolism.
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A metabolic signature of colon cancer initiating cells.
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A population model of folate-mediated one-carbon metabolism.
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A replicated molecular genetic basis for subtyping antisocial behavior in children with attention-deficit/hyperactivity disorder.
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Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease.
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Activation of the respiratory burst enzyme in human polymorphonuclear leukocytes by chemoattractants and other soluble stimuli. Evidence that the same oxidase is activated by different transductional mechanisms.
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Allelic differences in the brain-derived neurotrophic factor Val66Met polymorphism in late-life depression.
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Alteration of lithium pharmacology through manipulation of phosphoadenosine phosphate metabolism.
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Alternative translation initiation site usage results in two structurally distinct forms of Pit-1.
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Amphotericin B alters the affinity and functional activity of the oligopeptide chemotactic factor receptor on human polymorphonuclear leukocytes.
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Analysis of Homeostatic Mechanisms in Biochemical Networks.
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Analysis of Ras protein expression in mammalian cells.
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Antigen receptor control of methionine metabolism in T cells.
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BDNF Val66Met and spontaneous dyskinesias in non-clinical psychosis.
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BDNF Val66Met genotype and 6-month remission rates in late-life depression.
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Backbone dynamics of the monomeric lambda repressor denatured state ensemble under nondenaturing conditions.
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Betaine-homocysteine methyltransferase is a developmentally regulated enzyme crystallin in rhesus monkey lens.
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Binding of MetJ repressor to specific and nonspecific DNA and effect of S-adenosylmethionine on these interactions.
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Blood biomarkers of methylation in Down syndrome and metabolic simulations using a mathematical model.
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Brain-derived neurotrophic factor (BDNF) Val66Met and adulthood chronic stress interact to affect depressive symptoms.
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Brain-derived neurotrophic factor val66met polymorphism and hippocampal activation during episodic encoding and retrieval tasks.
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COMT and anxiety and cognition in children with chromosome 22q11.2 deletion syndrome.
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COMT val108/158 met genotype affects neural but not cognitive processing in healthy individuals.
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COMT158 polymorphism and hostility.
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Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine.
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Catechol O-methyltransferase val158met genotype and neural mechanisms related to affective arousal and regulation.
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Chemoattractant receptor affinity reflects its ability to transduce different biological responses.
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Chemoattractant receptor functions in human polymorphonuclear leukocytes are divergently altered by membrane fluidizers.
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Comparative quantitative trait loci mapping of aliphatic, indolic and benzylic glucosinolate production in Arabidopsis thaliana leaves and seeds.
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Comprehensive profiling of amino acid response uncovers unique methionine-deprived response dependent on intact creatine biosynthesis.
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Coordination of platinum therapeutic agents to met-rich motifs of human copper transport protein1.
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Correction: Mouse Models of Diet-Induced Nonalcoholic Steatohepatitis Reproduce the Heterogeneity of the Human Disease.
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Cryptococcus neoformans methionine synthase: expression analysis and requirement for virulence.
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Crystallization of a fragment of human fibronectin: introduction of methionine by site-directed mutagenesis to allow phasing via selenomethionine.
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Detection and characterization of methionine oxidation in peptides by collision-induced dissociation and electron capture dissociation.
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Development of specific receptors for N-formylated chemotactic peptides in a human monocyte cell line stimulated with lymphokines.
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Dietary Methionine in T Cell Biology and Autoimmune Disease.
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Dietary methionine influences therapy in mouse cancer models and alters human metabolism.
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Ecological genomics of Boechera stricta: identification of a QTL controlling the allocation of methionine- vs branched-chain amino acid-derived glucosinolates and levels of insect herbivory.
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Effects of a block in cysteine catabolism on energy balance and fat metabolism in mice.
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Evaluation of biosynthetic pathways of phosphatidyl choline in liver of rats given phenobarbital: a study on molecular species of phosphatidyl choline.
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Evidence for depression of nuclear protein synthesis and concomitant stimulation of nuclear RNA synthesis during early estrogen action.
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Evidence that the platinum-reactive methionyl residue of the alpha 2-macroglobulin receptor recognition site is not in the carboxyl-terminal receptor binding domain.
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Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death.
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G protein-coupled receptor Gpr4 senses amino acids and activates the cAMP-PKA pathway in Cryptococcus neoformans.
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Genetic variants in RUNX3, AMD1 and MSRA in the methionine metabolic pathway and survival in nonsmall cell lung cancer patients.
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Genetic vulnerability to affective psychopathology in childhood: a combined voxel-based morphometry and functional magnetic resonance imaging study.
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HNF4α regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer.
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Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease.
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Hepatic microsomal phospholipids in rats exposed intratracheally to coal fly ash.
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Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis.
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Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism.
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Imaging of human tumors and organs with N-13-labeled L-methionine.
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Immune response to p53 is dependent upon p53/HSP70 complexes in breast cancers.
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Impact of BDNF Val66Met and 5-HTTLPR polymorphism variants on neural substrates related to sadness and executive function.
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Improved excitation pulse bandwidths using shaped pulses, with application to heteronuclear half filters in macromolecular NMR.
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In silico experimentation with a model of hepatic mitochondrial folate metabolism.
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Incorporation of methionine-derived methyl groups into sirohaem by Escherichia coli.
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Influence of amino acids encoded in the 3' open reading frame of the SV40 early region on transformation and antigenicity of large T antigen.
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Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis.
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Inhibition of hepatic phosphatidylcholine synthesis by malathion in rats.
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Isoprenylation of a protein kinase. Requirement of farnesylation/alpha-carboxyl methylation for full enzymatic activity of rhodopsin kinase.
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L-Met Activates Arabidopsis GLR Ca2+
Channels Upstream of ROS Production and Regulates Stomatal Movement.
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Long-range allosteric interactions between the folate and methionine cycles stabilize DNA methylation reaction rate.
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Loss of the sigma activity of RNA polymerase of Bacillus subtilis during sporulation.
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Mass spectrometry-based thermal shift assay for protein-ligand binding analysis.
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Mechanistic study on the reaction of a radical SAM dehydrogenase BtrN by electron paramagnetic resonance spectroscopy.
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Metabolomic signatures of drug response phenotypes for ketamine and esketamine in subjects with refractory major depressive disorder: new mechanistic insights for rapid acting antidepressants.
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Methionine metabolism in health and cancer: a nexus of diet and precision medicine.
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Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width.
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Methionine metabolism is essential for SIRT1-regulated mouse embryonic stem cell maintenance and embryonic development.
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Methionine motifs of copper transport proteins provide general and flexible thioether-only binding sites for Cu(I) and Ag(I).
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Methionine oxidation of monomeric lambda repressor: the denatured state ensemble under nondenaturing conditions.
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Methionine sulfoxide and the oxidative regulation of plasma proteinase inhibitors.
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Methionine to glutamine substitutions in the C-terminal domain of calmodulin impair the activation of three protein kinases.
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Methylfolate Trap Promotes Bacterial Thymineless Death by Sulfa Drugs.
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Methylthioadenosine Suppresses Salmonella Virulence.
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Model Peptide Studies Reveal a Mixed Histidine-Methionine Cu(I) Binding Site at the N-Terminus of Human Copper Transporter 1.
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Modification of the tandem reactive centres of human inter-alpha-trypsin inhibitor with butanedione and cis-dichlorodiammineplatinum(II).
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Molecular and genetic analysis of the Cryptococcus neoformans MET3 gene and a met3 mutant.
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Mouse models of diet-induced nonalcoholic steatohepatitis reproduce the heterogeneity of the human disease.
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Mutational analysis of the function of Met137 and Ile197, two amino acids implicated in sequence-specific DNA recognition by the EcoRI endonuclease.
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Neurocognitive correlates of the COMT Val(158)Met polymorphism in chronic schizophrenia.
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Nuclear RNA synthesis in sea urchin embryos.
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Nutrient availability shapes methionine metabolism in p16/MTAP-deleted cells.
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One-carbon metabolism and epigenetics: understanding the specificity.
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One-methyl group metabolism in non-ketotic hyperglycinaemia: mildly elevated cerebrospinal fluid homocysteine levels.
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Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis.
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Oxidative dissociation of human alpha 2-macroglobulin tetramers into dysfunctional dimers.
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Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis.
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Pharmacologic treatment of uric acid calculi.
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Phospholipid methylation in macrophages is inhibited by chemotactic factors.
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Phosphorylation of DHBV pre-S: identification of the major site of phosphorylation and effects of mutations on the virus life cycle.
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Prefrontal-hippocampal coupling during memory processing is modulated by COMT val158met genotype.
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Protein imperfections: separating intrinsic from extrinsic variation of torsion angles.
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Rapid diagnosis of homocystinuria and other hypermethioninemias from newborns' blood spots by tandem mass spectrometry.
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Regulation of intracellular levels of calmodulin and tubulin in normal and transformed cells.
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Regulation of one-carbon metabolism in Arabidopsis: the N-terminal regulatory domain of cystathionine gamma-synthase is cleaved in response to folate starvation.
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Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium.
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Serine and Methionine Metabolism: Vulnerabilities in Lethal Prostate Cancer.
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Seven novel mutations in the adenosine deaminase (ADA) gene in patients with severe and delayed onset combined immunodeficiency: G74C, V129M, G140E, R149W, Q199P, 462delG, and E337del. Mutations in brief no. 142. Online.
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Short term methionine restriction increases hepatic global DNA methylation in adult but not young male C57BL/6J mice.
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Solution NMR studies of the A beta(1-40) and A beta(1-42) peptides establish that the Met35 oxidation state affects the mechanism of amyloid formation.
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Stable ribosome binding to the endoplasmic reticulum enables compartment-specific regulation of mRNA translation.
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Steroidogenic factor 1 is the essential transcript of the mouse Ftz-F1 gene.
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Stimulation of neutrophil oxidative metabolism by chemotactic peptides: influence of calcium ion concentration and cytochalasin B and comparison with stimulation by phorbol myristate acetate.
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Sulfite oxidase deficiency. Biochemical and clinical investigations of a hereditary metabolic disorder in sulfur metabolism.
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Suppression of tumor formation in vivo by expression of the JE gene in malignant cells.
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The 25 kDa synaptosomal-associated protein SNAP-25 is the major methionine-rich polypeptide in rapid axonal transport and a major substrate for palmitoylation in adult CNS.
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The COMT Val158Met polymorphism and temporal lobe morphometry in healthy adults.
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The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase.
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The brain-derived neurotrophic factor VAL66MET polymorphism and cerebral white matter hyperintensities in late-life depression.
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The relationship between intracellular and plasma levels of folate and metabolites in the methionine cycle: a model.
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The structure of PurR mutant L54M shows an alternative route to DNA kinking.
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Thermodynamic analysis of protein folding and stability using a tryptophan modification protocol.
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Thermodynamic analysis of protein-ligand interactions in complex biological mixtures using a shotgun proteomics approach.
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Visualizing and quantifying molecular goodness-of-fit: small-probe contact dots with explicit hydrogen atoms.
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cis-dichlorodiammineplatinum (II) as a selective modifier of the oxidation-sensitive reactive-center methionine in alpha 1-antitrypsin.
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Keywords of People