Methionine

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  Subject Areas on Research

  • A Mets motif peptide found in copper transport proteins selectively binds Cu(I) with methionine-only coordination. 
  • A bifunctional dihydrofolate synthetase--folylpolyglutamate synthetase in Plasmodium falciparum identified by functional complementation in yeast and bacteria. 
  • A comparison of methionine, histidine and cysteine in copper(I)-binding peptides reveals differences relevant to copper uptake by organisms in diverse environments. 
  • A gain-of-function polymorphism controlling complex traits and fitness in nature. 
  • A gene controlling variation in Arabidopsis glucosinolate composition is part of the methionine chain elongation pathway. 
  • A mathematical model gives insights into nutritional and genetic aspects of folate-mediated one-carbon metabolism. 
  • A mathematical model of the folate cycle: new insights into folate homeostasis. 
  • A mathematical model of the methionine cycle. 
  • A mathematical modelling approach to assessing the reliability of biomarkers of glutathione metabolism. 
  • A metabolic signature of colon cancer initiating cells. 
  • A population model of folate-mediated one-carbon metabolism. 
  • A replicated molecular genetic basis for subtyping antisocial behavior in children with attention-deficit/hyperactivity disorder. 
  • Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease. 
  • Activation of the respiratory burst enzyme in human polymorphonuclear leukocytes by chemoattractants and other soluble stimuli. Evidence that the same oxidase is activated by different transductional mechanisms. 
  • Allelic differences in the brain-derived neurotrophic factor Val66Met polymorphism in late-life depression. 
  • Alteration of lithium pharmacology through manipulation of phosphoadenosine phosphate metabolism. 
  • Alternative translation initiation site usage results in two structurally distinct forms of Pit-1. 
  • Amphotericin B alters the affinity and functional activity of the oligopeptide chemotactic factor receptor on human polymorphonuclear leukocytes. 
  • Analysis of Homeostatic Mechanisms in Biochemical Networks. 
  • Analysis of Ras protein expression in mammalian cells. 
  • BDNF Val66Met and spontaneous dyskinesias in non-clinical psychosis. 
  • BDNF Val66Met genotype and 6-month remission rates in late-life depression. 
  • Backbone dynamics of the monomeric lambda repressor denatured state ensemble under nondenaturing conditions. 
  • Balancing selection at the prion protein gene consistent with prehistoric kurulike epidemics. 
  • Betaine-homocysteine methyltransferase is a developmentally regulated enzyme crystallin in rhesus monkey lens. 
  • Binding of MetJ repressor to specific and nonspecific DNA and effect of S-adenosylmethionine on these interactions. 
  • Biochemical and genetic analyses of yeast and human high affinity copper transporters suggest a conserved mechanism for copper uptake. 
  • Blood biomarkers of methylation in Down syndrome and metabolic simulations using a mathematical model. 
  • Brain-derived neurotrophic factor (BDNF) Val66Met and adulthood chronic stress interact to affect depressive symptoms. 
  • Brain-derived neurotrophic factor val66met polymorphism and hippocampal activation during episodic encoding and retrieval tasks. 
  • COMT and anxiety and cognition in children with chromosome 22q11.2 deletion syndrome. 
  • COMT val108/158 met genotype affects neural but not cognitive processing in healthy individuals. 
  • COMT158 polymorphism and hostility. 
  • Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine. 
  • Catechol O-methyltransferase val158met genotype and neural mechanisms related to affective arousal and regulation. 
  • Chemoattractant receptor affinity reflects its ability to transduce different biological responses. 
  • Chemoattractant receptor functions in human polymorphonuclear leukocytes are divergently altered by membrane fluidizers. 
  • Comparative quantitative trait loci mapping of aliphatic, indolic and benzylic glucosinolate production in Arabidopsis thaliana leaves and seeds. 
  • Comprehensive profiling of amino acid response uncovers unique methionine-deprived response dependent on intact creatine biosynthesis. 
  • Coordination of platinum therapeutic agents to met-rich motifs of human copper transport protein1. 
  • Correction: Mouse Models of Diet-Induced Nonalcoholic Steatohepatitis Reproduce the Heterogeneity of the Human Disease. 
  • Cryptococcus neoformans methionine synthase: expression analysis and requirement for virulence. 
  • Crystallization of a fragment of human fibronectin: introduction of methionine by site-directed mutagenesis to allow phasing via selenomethionine. 
  • Detection and characterization of methionine oxidation in peptides by collision-induced dissociation and electron capture dissociation. 
  • Development of specific receptors for N-formylated chemotactic peptides in a human monocyte cell line stimulated with lymphokines. 
  • Ecological genomics of Boechera stricta: identification of a QTL controlling the allocation of methionine- vs branched-chain amino acid-derived glucosinolates and levels of insect herbivory. 
  • Effects of a block in cysteine catabolism on energy balance and fat metabolism in mice. 
  • Evaluation of biosynthetic pathways of phosphatidyl choline in liver of rats given phenobarbital: a study on molecular species of phosphatidyl choline. 
  • Evidence for depression of nuclear protein synthesis and concomitant stimulation of nuclear RNA synthesis during early estrogen action. 
  • Evidence that the platinum-reactive methionyl residue of the alpha 2-macroglobulin receptor recognition site is not in the carboxyl-terminal receptor binding domain. 
  • Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death. 
  • G protein-coupled receptor Gpr4 senses amino acids and activates the cAMP-PKA pathway in Cryptococcus neoformans. 
  • Genetic variants in RUNX3, AMD1 and MSRA in the methionine metabolic pathway and survival in nonsmall cell lung cancer patients. 
  • Genetic vulnerability to affective psychopathology in childhood: a combined voxel-based morphometry and functional magnetic resonance imaging study. 
  • Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease. 
  • Hepatic microsomal phospholipids in rats exposed intratracheally to coal fly ash. 
  • Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis. 
  • Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism. 
  • Identification of a vacuole-associated metalloreductase and its role in Ctr2-mediated intracellular copper mobilization. 
  • Identification of methionine-rich clusters that regulate copper-stimulated endocytosis of the human Ctr1 copper transporter. 
  • Imaging of human tumors and organs with N-13-labeled L-methionine. 
  • Immune response to p53 is dependent upon p53/HSP70 complexes in breast cancers. 
  • Impact of BDNF Val66Met and 5-HTTLPR polymorphism variants on neural substrates related to sadness and executive function. 
  • Improved excitation pulse bandwidths using shaped pulses, with application to heteronuclear half filters in macromolecular NMR. 
  • In silico experimentation with a model of hepatic mitochondrial folate metabolism. 
  • Incorporation of methionine-derived methyl groups into sirohaem by Escherichia coli. 
  • Influence of amino acids encoded in the 3' open reading frame of the SV40 early region on transformation and antigenicity of large T antigen. 
  • Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis. 
  • Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma. 
  • Inhibition of hepatic phosphatidylcholine synthesis by malathion in rats. 
  • Isoprenylation of a protein kinase. Requirement of farnesylation/alpha-carboxyl methylation for full enzymatic activity of rhodopsin kinase. 
  • L-Met Activates Arabidopsis GLR Ca2+ Channels Upstream of ROS Production and Regulates Stomatal Movement. 
  • Long-Range Allosteric Interactions between the Folate and Methionine Cycles Stabilize DNA Methylation Reaction Rate (vol 2, pg 81, 2006) 
  • Long-range allosteric interactions between the folate and methionine cycles stabilize DNA methylation reaction rate. 
  • Loss of the sigma activity of RNA polymerase of Bacillus subtilis during sporulation. 
  • Mass spectrometry-based thermal shift assay for protein-ligand binding analysis. 
  • Measurements of S-adenosylmethionine and L-homocysteine metabolism in cultured human lymphoid cells. 
  • Mechanistic study on the reaction of a radical SAM dehydrogenase BtrN by electron paramagnetic resonance spectroscopy. 
  • Metabolomic signatures of drug response phenotypes for ketamine and esketamine in subjects with refractory major depressive disorder: new mechanistic insights for rapid acting antidepressants. 
  • Methionine metabolism in health and cancer: a nexus of diet and precision medicine. 
  • Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width. 
  • Methionine metabolism is essential for SIRT1-regulated mouse embryonic stem cell maintenance and embryonic development. 
  • Methionine motifs of copper transport proteins provide general and flexible thioether-only binding sites for Cu(I) and Ag(I). 
  • Methionine oxidation of monomeric lambda repressor: the denatured state ensemble under nondenaturing conditions. 
  • Methionine sulfoxide and the oxidative regulation of plasma proteinase inhibitors. 
  • Methionine to glutamine substitutions in the C-terminal domain of calmodulin impair the activation of three protein kinases. 
  • Methylfolate Trap Promotes Bacterial Thymineless Death by Sulfa Drugs. 
  • Methylthioadenosine Suppresses Salmonella Virulence. 
  • Mobilization of intracellular copper stores by the ctr2 vacuolar copper transporter. 
  • Model Peptide Studies Reveal a Mixed Histidine-Methionine Cu(I) Binding Site at the N-Terminus of Human Copper Transporter 1. 
  • Modification of the tandem reactive centres of human inter-alpha-trypsin inhibitor with butanedione and cis-dichlorodiammineplatinum(II). 
  • Molecular and genetic analysis of the Cryptococcus neoformans MET3 gene and a met3 mutant. 
  • Mouse models of diet-induced nonalcoholic steatohepatitis reproduce the heterogeneity of the human disease. 
  • Mutational analysis of the function of Met137 and Ile197, two amino acids implicated in sequence-specific DNA recognition by the EcoRI endonuclease. 
  • Mutational pattern of hepatitis B virus on sequential therapy with famciclovir and lamivudine in patients with hepatitis B virus reinfection occurring under HBIg immunoglobulin after liver transplantation. 
  • Neurocognitive correlates of the COMT Val(158)Met polymorphism in chronic schizophrenia. 
  • Nuclear RNA synthesis in sea urchin embryos. 
  • One-carbon metabolism and epigenetics: understanding the specificity. 
  • One-methyl group metabolism in non-ketotic hyperglycinaemia: mildly elevated cerebrospinal fluid homocysteine levels. 
  • Osmoltye and tryptophan receptors controlling gastric emptying in the dog. 
  • Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis. 
  • Oxidative dissociation of human alpha 2-macroglobulin tetramers into dysfunctional dimers. 
  • Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis. 
  • Pharmacologic treatment of uric acid calculi. 
  • Phospholipid methylation in macrophages is inhibited by chemotactic factors. 
  • Phosphorylation of DHBV pre-S: identification of the major site of phosphorylation and effects of mutations on the virus life cycle. 
  • Prefrontal-hippocampal coupling during memory processing is modulated by COMT val158met genotype. 
  • Protein imperfections: separating intrinsic from extrinsic variation of torsion angles. 
  • Rapid diagnosis of homocystinuria and other hypermethioninemias from newborns' blood spots by tandem mass spectrometry. 
  • Regulation of intracellular levels of calmodulin and tubulin in normal and transformed cells. 
  • Regulation of one-carbon metabolism in Arabidopsis: the N-terminal regulatory domain of cystathionine gamma-synthase is cleaved in response to folate starvation. 
  • Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium. 
  • Serine and Methionine Metabolism: Vulnerabilities in Lethal Prostate Cancer. 
  • Seven novel mutations in the adenosine deaminase (ADA) gene in patients with severe and delayed onset combined immunodeficiency: G74C, V129M, G140E, R149W, Q199P, 462delG, and E337del. Mutations in brief no. 142. Online. 
  • Short term methionine restriction increases hepatic global DNA methylation in adult but not young male C57BL/6J mice. 
  • Solution NMR studies of the A beta(1-40) and A beta(1-42) peptides establish that the Met35 oxidation state affects the mechanism of amyloid formation. 
  • Stable ribosome binding to the endoplasmic reticulum enables compartment-specific regulation of mRNA translation. 
  • Steroidogenic factor 1 is the essential transcript of the mouse Ftz-F1 gene. 
  • Stimulation of neutrophil oxidative metabolism by chemotactic peptides: influence of calcium ion concentration and cytochalasin B and comparison with stimulation by phorbol myristate acetate. 
  • Sulfite oxidase deficiency. Biochemical and clinical investigations of a hereditary metabolic disorder in sulfur metabolism. 
  • Suppression of tumor formation in vivo by expression of the JE gene in malignant cells. 
  • The 25 kDa synaptosomal-associated protein SNAP-25 is the major methionine-rich polypeptide in rapid axonal transport and a major substrate for palmitoylation in adult CNS. 
  • The COMT Val158Met polymorphism and temporal lobe morphometry in healthy adults. 
  • The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase. 
  • The brain-derived neurotrophic factor VAL66MET polymorphism and cerebral white matter hyperintensities in late-life depression. 
  • The relationship between intracellular and plasma levels of folate and metabolites in the methionine cycle: a model. 
  • The structure of PurR mutant L54M shows an alternative route to DNA kinking. 
  • Thermodynamic analysis of protein folding and stability using a tryptophan modification protocol. 
  • Thermodynamic analysis of protein-ligand interactions in complex biological mixtures using a shotgun proteomics approach. 
  • Visualizing and quantifying molecular goodness-of-fit: small-probe contact dots with explicit hydrogen atoms. 
  • cis-dichlorodiammineplatinum (II) as a selective modifier of the oxidation-sensitive reactive-center methionine in alpha 1-antitrypsin. 
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  Keywords of People

  • Preminger, Glenn Michael, James F. Glenn, M.D. Distinguished Professor of Urology, Surgery