Methods

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  Subject Areas on Research

  • 3-Halo-5,7-dimethylpyrazolo [1,5-a]pyrimidines, a nonbenzodiazepinoid class of antianxiety agents devoid of potentiation of central nervous system depressant effects of ethanol or barbiturates. 
  • A Bayesian method for synthesizing evidence. The Confidence Profile Method. 
  • A New Resource for Characterizing X-linked Genes in Drosophila melanogaster: Systematic Coverage and Subdivision of the X Chromosome with Nested, Y-linked Duplications. 
  • A cell culture system that enhances mononuclear cell IgE synthesis induced by recombinant human interleukin-4. 
  • A clinical comparison of mitral valve repair versus valve replacement in ischemic mitral regurgitation. 
  • A comparison of the leukocyte agglutination and mixed agglutination techniques for detecting human tissue isoantigens. 
  • A continuously monitored spectrophotometric assay of glycosidases with nitrophenyl glycosides. 
  • A generalized estimator of the attributable benefit of an optimal treatment regime. 
  • A high resolution structure of an inhibitor complex of the extracellular nuclease of Staphylococcus aureus. I. Experimental procedures and chain tracing. 
  • A method for the continuous calculation of the age of labeled red blood cells. 
  • A new purification procedure for bovine milk xanthine oxidase: effect of proteolysis on the subunit structure. 
  • A new technique for combined liver/small intestinal transplantation. 
  • A novel method for volumetric MRI response assessment of enhancing brain tumors. 
  • A quantitative analysis of beta-adrenergic receptor interactions: resolution of high and low affinity states of the receptor by computer modeling of ligand binding data. 
  • A rapid method for the isolation and partial purification of specific eucaryotic messenger RNA's. 
  • A rapid micromethod for determination of FMN and FAD in mixtures. 
  • A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. 
  • A re-examination of the gas chromatographic determination of -d-propoxyphene. 
  • A simple method of transurethral photography. 
  • A simple technique for the measurement of swimming speed of Chlamydomonas. 
  • A survey of digital chest radiography. 
  • Activation of beef heart mitochondrial adenosine triphosphatase by 2,4-dinitrophenol. 
  • Affinity chromatography of beta-hydroxybutyrate dehydrogenase on Nad and hydrophobic chain derivatives of sepharose. 
  • An automated dry-slide enzymatic method evaluated for measurement of creatinine in serum. 
  • An electronic method for counting human T and B cell rosettes. 
  • An improved technique for producing ventricular hypertrophy with a subcoronary valvular aortic stenosis model. 
  • An in-vitro morphological study of Q-switched neodymium/YAG laser trabeculotomy. 
  • An introduction to a Bayesian method for meta-analysis: The confidence profile method. 
  • An inverse electrocardiographic solution with an ON-OFF model. 
  • An isolated perfused rat lung preparation. 
  • An overview of the laboratory diagnosis of lead poisoning. 
  • Analysis of asbestos fibers and asbestos bodies in tissue samples from human lung. An international interlaboratory trial. 
  • Angiogenesis and growth of isografted bone: quantitative in vivo assay in nude mice. 
  • Angle independent ultrasonic blood flow detection by frame-to-frame correlation of B-mode images. 
  • Anomalous MLR responsiveness among siblings. 
  • Anorectal melanoma: clinical characteristics and the role of abdominoperineal resection. 
  • Anterior intervertebral discectomy and arthrodesis for treatment of low back pain with or without radiculopathy. 
  • Application of a modified 203Hg binding assay for metallothionein. 
  • Application of posterior neck dissection in treating malignant melanoma of the posterior scalp. 
  • Arterial shunting as an adjunct to major limb revascularization. 
  • Arthroscopic bioabsorbable tack stabilization of initial anterior shoulder dislocations: a preliminary report. 
  • Arthroscopic fixation of superior labral lesions using a biodegradable implant: a preliminary report. 
  • Atopic dermatitis--a new therapeutic regimen. 
  • Bayesian semiparametric multiple shrinkage. 
  • Bayesian variable selection for latent class models. 
  • Behavioral treatment of obesity in children. 
  • Biliary flora and antimicrobial concentrations after Kasai's operation. 
  • Boutonnière deformity: a surgical corrective procedure. 
  • Broadening of the RF power-density window for calcium-ion efflux from brain tissue. 
  • Caffeine in plasma and saliva by a radioimmunoassay procedure. 
  • Cell cycle analysis of budding yeast using SYTOX Green. 
  • Cervicovaginal fistula formation: a new complication of Shirodkar cerclage. 
  • Characteristics of transverse electric and magnetic field transmission cells at extremely low frequencies. 
  • Characterization of the poly-T variant in the TOMM40 gene in diverse populations. 
  • Characterizing functional stem cell-cardiomyocyte interactions. 
  • Chemoattractant-induced membrane phenomena of phagocytes. 
  • Chronic boutonniere deformity--an anatomic reconstruction. 
  • Clinical laboratory evaluation of the American optical Bilirubinometer. 
  • Clinical use of bone allografts in the elbow. 
  • Collision of excitation waves in the dog Purkinje system. Extracellular identification. 
  • Comparison of a chemical assay with a tissue-mediated bio-assay for chemical mutagens. 
  • Comparison of actual and simulated EMG biofeedback in the treatment of hemiplegic patients. 
  • Comparison of atmospheres of incubation for primary isolation of Campylobacter fetus subsp. jejuni from animal specimens: 5% oxygen versus candle jar. 
  • Comparison of cardiovascular biofeedback, neuromuscular biofeedback, and meditation in the treatment of borderline essential hypertension. 
  • Comparison of intravascular ultrasound, external ultrasound and digital angiography for evaluation of peripheral artery dimensions and morphology. 
  • Comparisons of mixed leukocyte reactions with skin graft survival in families genotyped for HL-A. 
  • Computing inverse solutions for an on-off heart model. 
  • Concerted nitric oxide/oxygen delivery by hemoglobin. 
  • Construction of low-variability litters of preweaning mice. 
  • Continuous-flow determination of dialyzable calcium in serum. 
  • Coronary flow and regional function before and after supraarterial myotomy for myocardial bridging. 
  • Correction of post-traumatic flexion contracture of the elbow by anterior capsulotomy. 
  • Current density and electrically induced ventricular fibrillation. 
  • Cytokine profiling using monocytes/macrophages cultured on common biomaterials with a range of surface chemistries. 
  • Cytologic studies of glucose-6-phosphate dehydrogenase in malignancy. 
  • Design and inference for cancer biomarker study with an outcome and auxiliary-dependent subsampling. 
  • Detection of methanesulfonic acid in ethyl methanesulfonate. 
  • Detection of mutations by cleavage of DNA heteroduplexes with bacteriophage resolvases. 
  • Diagnosis and management of pheochromocytoma. 
  • Diagnosis and treatment of primary extrahepatic bile duct tumors. 
  • Dose response studies in cotton textile workers. 
  • Dosimetry of the chemical mutagen ethyl methanesulfonate in spermatozoan DNA from Drosophila melanogaster. 
  • Effect of cyclosporine on bile secretion in rats. 
  • Effect of hyperbaric oxygenation on left ventricular function. 
  • Electron microscopic study of the base sequence in nucleic acids. VI. Preparation of ribonucleic acid with marked gauanosine monophosphate nucleotides. 
  • Electrophysiologic effects of surgical isolation of the right ventricle. 
  • Empirical Bayes procedures for stabilizing maps of U.S. cancer mortality rates. 
  • Enlargement of mediastinal masses on simulation films: a radiotherapeutic problem in the management of patients with Hodgkin's disease. 
  • Enzymatic joining of polynucleotides. IX. A simple and rapid assay of polynucleotide joining (ligase) activity by measurement of circle formation from linear deoxyadenylate-deoxythymidylate copolymer. 
  • Enzymatic susceptibility and spontaneous release of human melanoma tumor-associated antigens. 
  • Equivalency of various methods for estimating osteoid seam width. 
  • Evaluation of an audio mode of the automated medical history. 
  • Evaluation of selective liver denervation methods. 
  • Evaluation of several methods for computing stroke volume from central aortic pressure. 
  • Excitation sequences of the atrial septum and the AV node in isolated hearts of the dog and rabbit. 
  • Experience with the AMS 600 malleable penile prosthesis. 
  • Experimental basis for QRS and T wave potentials in the WPW syndrome. The relation of epicardial to body surface potential distributions in the intact chimpanzee. 
  • Experimental effects of hyperbaric oxgen on selected clostridial species. I. In-vitro studies. 
  • Experimental effects of hyperbaric oxygen on selected clostridial species. II. In-vitro studies in mice. 
  • Exploratory electrocardiography: use of isopotential surface maps. 
  • Failure of the Hemashield extension in right ventricle-to-pulmonary artery conduits. 
  • Further notes on gravimetric serum total lipid determinations. 
  • GTP hydrolysis during microtubule assembly. 
  • Gene transfer and expression in rat cardiac transplants. 
  • Goniotomy vs external trabeculotomy for developmental glaucoma. 
  • Growth and lability of Chaetopterus oocyte mitotic spindles isolated in the presence of porcine brain tubulin. 
  • Guidelines on the use of therapeutic apheresis in clinical practice--evidence-based approach from the Apheresis Applications Committee of the American Society for Apheresis. 
  • Hemodynamic consequences of right ventricular isolation: the contribution of the right ventricular free wall to cardiac performance. 
  • High hip center in revision arthroplasty. 
  • Images for surgeons. Concomitant open surgical repair of an abdominal aortic aneurysm and endovascular repair of a thoracic aortic aneurysm. 
  • Immunogenetics of consanguineous allografts in man. I. Histocompatibility testing and skin allografts. 
  • Improved methods and standards for telomerase detection: quantitative histopathology using antibody staining. 
  • Improved motility recovery of human spermatozoa after freeze preservation via a new approach. 
  • Improved techniques for staining and enumerating focus formation in viral infectivity assays. 
  • Improving the accuracy of intercensal estimates and postcensal projections of the civilian noninstitutional population: a parameterization of institutional prevalence rates. 
  • In vitro culture and differentiation on normal mouse blastocysts. 
  • In vitro studies with a pulsed neodymium/YAG laser. 
  • In vivo dendritic cell tracking using fluorescence lifetime imaging and near-infrared-emissive polymersomes. 
  • In vivo measurements of ultrasonic beam distortion in the breast. 
  • In-111 platelet scintigraphy: carotid atherosclerosis and stroke. 
  • Induction of specific translatable messenger RNA's by oestrogen and progesterone. 
  • Isolation and characterization of C4-synthesizing cells from guinea-pig spleen. 
  • Issues affecting minority participation in research studies of Alzheimer disease. 
  • Knee flexion contractures in myelodysplasia. 
  • Laceration of the flexor pollicis longus tendon: delayed repair by advancement, free graft or direct suture. A clinical and experimental study. 
  • Left ventricular pressure-volume characteristics in congenital heart disease. 
  • Limulus amebocyte lysate test in neonates. 
  • Locational stereology performed within sampling fields in rat aortic wall, a polarized tissue. 
  • Lower pole calicostomy for the management of iatrogenic ureteropelvic junction obstruction. 
  • MR imaging of normal extrahepatic bile ducts. 
  • Male urethral diverticulum: the double density sign. 
  • Management of anterior vitreous traction in proliferative vitreoretinopathy. 
  • Management of congenital microgastria with a jejunal reservoir pouch. 
  • Management of the bladder outlet in patients requiring enterocystoplasty. 
  • Management of traumatic posterior urethral stricture by one stage perineal repair. 
  • Mean platelet volume improves upon the megathrombocyte index but cannot replace the blood film examination in the evaluation of thrombocytopenia. 
  • Measurement of aortic blood flow in man by the computed pressure derivative method. 
  • Measurement of fibrinogen degradation products. 
  • Measuring nitric oxide production in human clinical studies. 
  • MetJ repressor interactions with DNA probed by in-cell NMR. 
  • Metabolic cross-talk allows labeling of O-linked beta-N-acetylglucosamine-modified proteins via the N-acetylgalactosamine salvage pathway. 
  • Methods for comparing the mortality experience of heterogeneous populations. 
  • Methods for measurement of body surface area. 
  • Methods for national population forecasts: a review. 
  • Methods for the analysis of mortality risks across heterogeneous small populations: examination of space-time gradients in cancer mortality in North Carolina counties 1970-75. 
  • Methods of measuring swimming speed of spermatozoa. 
  • Microvascular anastomosis: an experimental model utilizing the rabbit ear. 
  • Midtrimester abortion induced with a single intra-amniotic instillation of prostaglandin F2 alpha. 
  • Model validation: local diagnosis, correction and when to quit. 
  • Morphometric analysis of spermatozoa in the assessment of human male fertility. 
  • Neuroleptic-induced oral movements in rats: methodological issues. 
  • Nuclear RNA synthesis in sea urchin embryos. 
  • Observations upon small gut "mucosal" pO2 and pCO2 in anesthetized dogs. 
  • Osteomalacia after parathyroidectomy in patients with uremia. 
  • Oxygen kinetics in preretinal perfluorotributylamine. 
  • Pain management programs. Clinical and research perspectives. 
  • Parotid and whole saliva in the prediction of serum total and free phenytoin concentrations. 
  • Partial restoration of normal functional properties in carboxypeptidase A-digested hemoglobin. 
  • Patterns of failure following local excision and local excision and postoperative radiation therapy for invasive rectal adenocarcinoma. 
  • Penile prosthesis for impotence in multiple sclerosis. 
  • Percutaneous approach to nephrolithiasis. 
  • Percutaneous ureterolithotomy. 
  • Perineal repair of membranous urethral stricture. 
  • Perineal transpubic repair: a technique for treating post-traumatic prostatomembranous urethral strictures. 
  • Placental transport of free palmitic and linoleic acids in the guinea pig. 
  • Planning the size and duration of a clinical trial studying the time to some critical event. 
  • Plant Antitumor Agents. VI. The Isolation and Structure of Taxol, a Novel Antileukemic and Antitumor Agent from Taxus brevifolia 
  • Plasma renin activity following operations for renovascular hypertension. 
  • Plasma therapy in immunodeficiency diseases. 
  • Positional variation in the Whitaker test. 
  • Preparative solvent partition chromatography of butyrylated cyclic AMP analogues. 
  • Pressure and volume changes of the left ventricle in acute pericardial tamponade. 
  • Problems in placement of the Greenfield inferior vena cava filter. 
  • Processing of arterial pressure waves with a digital computer. 
  • Progress in medical information management. Systematized nomenclature of medicine (SNOMED). 
  • Prospective phase I trial of conservative management of low rectal lesions. 
  • Protein biosynthesis in the testis. V. Concerning the mechanism of stimulation by follicle-stimulating hormone. 
  • Protein bisoynthesis in the testis. IV. Isolation and properties of polyribosomes. 
  • Pulmonary wedge catheter. 
  • Purification and properties of EcoRI endonuclease. 
  • Pylorus-preserving pancreatoduodenectomy. A clinical and physiologic appraisal. 
  • Quantification of insensible water loss associated with insufflation of nonhumidified CO2 in patients undergoing laparoscopic surgery. 
  • Quantitative determination of total lipids in serum. 
  • Radical anterior segment surgery for epithelial invasion of the anterior chamber: report of three cases. 
  • Radiommunoassay of delta9-tetrahydrocannabinol. 
  • Radioreceptor assay of adrenocorticotropic hormone: new approach to assay of polypeptide hormones in plasma. 
  • Recruitment experience in the first phase of the African American Hereditary Prostate Cancer (AAHPC) study. 
  • Regional cerebral blood flow estimated by 133-xenon inhalation. 
  • Regional diffusing capacity in normal lungs during a slow exhalation. 
  • Reimplantation of amputated digits and hands. 
  • Reliability of single-lead and multiple-lead electrocardiography during and after exercise. 
  • Repair of pelvic fracture posterior urethral defects using an elaborated perineal approach: experience with 74 cases. 
  • Results of 233 peripheral iridectomies for narrow-angle glaucoma. 
  • Retrograde urethrogram: diagnostic aid and hazard. 
  • Reversibility of sterilization produced by vas occlusion clip. 
  • Rhodamine 123 as a probe of transmembrane potential in isolated rat-liver mitochondria: spectral and metabolic properties. 
  • Right ventricular isolation procedures for nonischemic ventricular tachycardia. 
  • Sedimentation and volume analysis of human bone marrow. 
  • Selection factors for local excision or abdominoperineal resection of early stage rectal cancer. 
  • Semen analysis. 
  • Semiparametric Bayes multiple testing: Applications to tumor data. 
  • Sensitivity analysis on a chance node with more than two branches. 
  • Separation & estimation of human serum lipids by silicic acid column chromatography. 
  • Separation of retinol from neutral lipids and phospholipids by silicic acid. 
  • Short-term prophylaxis of pulmonary embolism by using a retrievable vena cava filter. 
  • Simplified technique for vasography. 
  • Simultaneous and completely automated methods for serum iron and iron-binding capacity determinations. 
  • Single Steinmann pin fixation of arm to leg. Case report. 
  • Smooth nonparametric maximum likelihood estimation for population pharmacokinetics, with application to quinidine. 
  • Strain MC29 avian leukosis virus release by chick embryo cells infected with the agent. 
  • Surgical correction of Peyronie's disease: the Nesbit procedure. 
  • Survivorship analysis of cemented total hip arthroplasty acetabular components implanted with second-generation techniques. 
  • Symposium on renal lithiasis. The challenge of calculi in children. 
  • Teaching pediatric pathology in a core curri curriculum. 
  • Technical note--auditory feedback of knee angle for amputees. 
  • The "blind side" of the medial meniscus. 
  • The case for careful examination of the placenta. Helpful information from the delivery room. 
  • The challenge of measuring community values in ways appropriate for setting health care priorities. 
  • The effect of fibrin polymerization inhibitors on quantitative measurements of plasma fibrinogen. 
  • The effect of fibrin-stabilizing factor on the subunit structure of human fibrin. 
  • The effects of stimulating the dorsal columns of man. 
  • The energetics of bird flight. 
  • The histological effect of barrier vein wrapping of peripheral nerves. 
  • The impact of current staging procedures in assessing disease extent of prostatic adenocarcinoma. 
  • The influence of magnitude and duration of crush load on functional recovery of the peripheral nerve. 
  • The investigation of the behavior of microorganisms by computerized television. 
  • The lymphatics of the groin flap. 
  • The microsurgical triple clamp: a technique for microvascular grafting of short interposition grafts. 
  • The natural history of coronary artery disease: an update on surgical and medical management. 
  • The operant assessment of taste discrimination. 
  • The outcome of transvaginal cystourethropexy in patients with anatomical stress urinary incontinence and outlet weakness. 
  • The preparation and properties of an antiserum for the radioimmunoassay of serum conjugated cholic acid. 
  • The radiology of thoracic trauma. 
  • The rapid and large scale separation of peritoneal macrophages. 
  • The relationship between the motility and morphology of spermatozoa in human semen. 
  • The role of feedback in voluntary control of blood pressure in instructed subjects. 
  • The selection of medical students at McMaster University. 
  • The significance of coronary calcification detected by fluoroscopy. A report of 360 patients. 
  • The simple construction of protein alpha-carbon models. 
  • The use of in vitro technics to study drug-induced pancytopenia. 
  • The use of isopotential surface maps in understanding clinical ECGs. 
  • The use of silicone oil following failed vitrectomy for retinal detachment with advanced proliferative vitreoretinopathy. 
  • The viscosity of neutrophils and their transit times through small pores. 
  • Tissue antigens of man and chimpanzees; their role in xenografting. 
  • Total hip replacement in Gaucher's disease. 
  • Trans-splicing reactions by ribozymes. 
  • Transplantation of the parathyroid glands in man: clinical indications and results. 
  • Troubleshooting the malfunctioning Scott artificial urinary sphincter. 
  • Ultrasound speckle size and lesion signal to noise ratio: verification of theory. 
  • Urethroplasty management in 100 cases of urethral stricture: a rationale for procedure selection. 
  • Urologic complications in renal transplantation. 
  • Urologic complications in renal transplantation. 
  • Urologic morbidity in renal transplantation. 
  • Use of Sepharose 4B for preparative scale fractionation of eukaryotic messenger RNA's. 
  • Use of the anterior branch of the medial antebrachial cutaneous nerve as a graft for the repair of defects of the digital nerve. 
  • Use of the rectus abdominis muscle flap in urological reconstructive procedures. 
  • Using physician claims to identify postoperative complications of carotid endarterectomy. 
  • Values for intrarenal distribution of blood flow using xenon-133 in the anesthetized dog. 
  • Variation in response to hyperbaric oxygen among inbred strains of mice. 
  • Variations in strategy for the treatment of urethral obstruction after a pubovaginal sling procedure. 
  • Vascularized transplantation of skeletal muscle: a case report. 
  • Vectorcardiographic criteria for the diagnosis of inferior myocardial infarction. 
  • Warfarin enantiomer disposition: determination by stereoselective radioimmunoassay. 
  • Work force planning in the 90s, Part I: Efficiency, economy and political will--the need for a new approach. 
  • Z-plasty modification of the Lynch incision. 
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  Keywords of People

  • Attarian, David Edward, Professor of Orthopaedic Surgery, Orthopaedic Surgery
  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Bradford, William Dalton, Professor of Pathology, Pathology
  • Cianciolo, George James, Associate Professor Emeritus of Pathology, Pathology
  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Grambow, Steven C., Associate Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics
  • Johnson, G. Allan, Charles E. Putman University Distinguished Professor of Radiology, Biomedical Engineering
  • Nielsen, Karen Cristina, Associate Professor of Anesthesiology, Anesthesiology, Ambulatory
  • Pan, Wei, Associate Professor in the School of Nursing, School of Nursing
  • Preminger, Glenn Michael, James F. Glenn, M.D. Distinguished Professor of Urology, Surgery, Urology
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Biomedical Engineering
  • Sullivan, Daniel Carl, Professor Emeritus of Radiology, Radiology
  • Woldorff, Marty G., Professor in Psychiatry and Behavioral Sciences, Duke Science & Society