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Subject Areas on Research
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(3H)norepinephrine binding: unrelated to catechol-O-methyl transferase.
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A Randomized Controlled Trial to Determine the Effect of Depth of Anesthesia on Emergence Agitation in Children.
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Absence of biochemical evidence for renal and hepatic dysfunction after 8 hours of 1.25 minimum alveolar concentration sevoflurane anesthesia in volunteers.
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Acute and Long-Term Effects of Brief Sevoflurane Anesthesia During the Early Postnatal Period in Rats.
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An evaluation of remifentanil-sevoflurane response surface models in patients emerging from anesthesia: model improvement using effect-site sevoflurane concentrations.
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Anti-inflammatory signaling during ex vivo liver perfusion improves the preservation of pig liver grafts before transplantation.
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Assessment of low-flow sevoflurane and isoflurane effects on renal function using sensitive markers of tubular toxicity.
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Avoiding Cardiovascular Collapse: Pediatric Cutaneous Mastocytosis and Anesthetic Challenges.
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Biotransformation of L-cysteine S-conjugates and N-acetyl-L-cysteine S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in human kidney in vitro: interindividual variability in N-acetylation, N-deacetylation, and beta-lyase-catalyzed metabolism.
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Biotransformation of sevoflurane.
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Biotreatment of groundwater contaminated with MTBE: interaction of common environmental co-contaminants.
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Cardiac arrhythmias following anesthesia induction in infantile-onset Pompe disease: a case series.
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Clinical sevoflurane metabolism and disposition. I. Sevoflurane and metabolite pharmacokinetics.
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Clinical sevoflurane metabolism and disposition. II. The role of cytochrome P450 2E1 in fluoride and hexafluoroisopropanol formation.
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Comparison of Amsorb, sodalime, and Baralyme degradation of volatile anesthetics and formation of carbon monoxide and compound a in swine in vivo.
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Comparison of renal function following anesthesia with low-flow sevoflurane and isoflurane.
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Compound A uptake and metabolism to mercapturic acids and 3,3,3-trifluoro-2-fluoromethoxypropanoic acid during low-flow sevoflurane anesthesia: biomarkers for exposure, risk assessment, and interspecies comparison.
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Cytotoxicity of S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl) vinyl ether (Compound A) in a human proximal tubular cell line.
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Effect of sevoflurane on P50 and on measurement of oxygen tension.
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Evidence for metabolism of fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A), a sevoflurane degradation product, by cysteine conjugate beta-lyase.
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Gene expression profiling of nephrotoxicity from the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether ("compound A") in rats.
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Getting oil and water to mix.
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Glutathione S-conjugation of the sevoflurane degradation product, fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in human liver, kidney, and blood in vitro.
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Heart rate variability dynamics during controlled hypotension with nicardipine, remifentanil and dexmedetomidine.
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Human kidney methoxyflurane and sevoflurane metabolism. Intrarenal fluoride production as a possible mechanism of methoxyflurane nephrotoxicity.
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Hyperbaric oxygen therapy and neurological disease.
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Identification in rat bile of glutathione conjugates of fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether, a nephrotoxic degradate of the anesthetic agent sevoflurane.
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Identification of cytochrome P450 2E1 as the predominant enzyme catalyzing human liver microsomal defluorination of sevoflurane, isoflurane, and methoxyflurane.
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Long-duration low-flow sevoflurane and isoflurane effects on postoperative renal and hepatic function.
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Long-term human pluripotent stem cell self-renewal on synthetic polymer surfaces.
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Low-flow sevoflurane compared with low-flow isoflurane anesthesia in patients with stable renal insufficiency.
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Metabolism and toxicity of the new anesthetic agents.
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Methyl tert-butyl ether (MTBE) degradation by a microbial consortium.
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Modified extraction procedure for gas-liquid chromatography applied to the identification of anaerobic bacteria.
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Myocardial ischemia and adverse cardiac outcomes in cardiac patients undergoing noncardiac surgery with sevoflurane and isoflurane. Sevoflurane Ischemia Study Group.
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Nephrotoxicity of sevoflurane compound A [fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether] in rats: evidence for glutathione and cysteine conjugate formation and the role of renal cysteine conjugate beta-lyase.
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Odor and volatile organic compound removal from wastewater treatment plant headworks ventilation air using a biofilter.
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Opioid-volatile anesthetic synergy: a response surface model with remifentanil and sevoflurane as prototypes.
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P450-dependent and nonenzymatic human liver microsomal defluorination of fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A), a sevoflurane degradation product.
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Pharmacovigilance and safety aspects of sevoflurane.
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Response to 'Correlation between bispectral index and age-adjusted minimal alveolar concentration' (Br J Anaesth 2020; 124:e8).
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Role of cytochrome P4503A in cysteine S-conjugates sulfoxidation and the nephrotoxicity of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in rats.
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Role of renal cysteine conjugate beta-lyase in the mechanism of compound A nephrotoxicity in rats.
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Safety of low-flow sevoflurane anesthesia in patients with chronically impaired renal function is not proven.
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Sevoflurane Induces Coherent Slow-Delta Oscillations in Rats.
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Sevoflurane and halothane reduce focal ischemic brain damage in the rat. Possible influence on thermoregulation.
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Sevoflurane formulation water content influences degradation by Lewis acids in vaporizers.
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Sevoflurane, fluoride ion, and renal toxicity.
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Source proximity and outdoor-residential VOC concentrations: results from the RIOPA study.
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Spectrum and subcellular determinants of fluorinated anesthetic-mediated proximal tubular injury.
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Speed of recovery and side-effect profile of sevoflurane sedation compared with midazolam.
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Sulfoxidation of cysteine and mercapturic acid conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A).
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The effect of isoflurane on neuronal necrosis following near-complete forebrain ischemia in the rat.
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The hemodynamic and renal effects of sevoflurane and isoflurane in patients with coronary artery disease and chronic hypertension. Sevoflurane Ischemia Study Group.
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Time-varying spectral analysis revealing differential effects of sevoflurane anaesthesia: non-rhythmic-to-rhythmic ratio.
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Toxicity of methyl-tert-butyl ether to freshwater organisms.
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When is a bispectral index of 60 too low?: Rational processed electroencephalographic targets are dependent on the sedative-opioid ratio.
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Xenon and sevoflurane provide analgesia during labor and fetal brain protection in a perinatal rat model of hypoxia-ischemia.
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[Compound A: toxicology and clinical relevance].