Methylation

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  Subject Areas on Research

  • 2'-O-Methylation can increase the abundance and lifetime of alternative RNA conformational states. 
  • 2'-deoxy-5-azacytidine increases binding of cisplatin to DNA by a mechanism independent of DNA hypomethylation. 
  • A comparison of the extents of methylation of vesicular stomatitis virus messenger RNA. 
  • A mathematical model gives insights into nutritional and genetic aspects of folate-mediated one-carbon metabolism. 
  • A novel domain in Set2 mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation. 
  • ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia. 
  • Absence of S100A4 in the mouse lens induces an aberrant retina-specific differentiation program and cataract. 
  • Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance. 
  • Adenosine-deaminase-deficient mice die perinatally and exhibit liver-cell degeneration, atelectasis and small intestinal cell death. 
  • Age-associated epigenetic change in chimpanzees and humans. 
  • Alteration of the alkaloid profile in genetically modified tobacco reveals a role of methylenetetrahydrofolate reductase in nicotine N-demethylation. 
  • Alterations of new methylated phospholipid synthesis in the plasma membranes of macrophages exposed to chemoattractants. 
  • Altered regulation of S-adenosylmethionine dependent methylation in adenosine deaminase deficiency. 
  • An improved isoprenylcysteine carboxylmethyltransferase inhibitor induces cancer cell death and attenuates tumor growth in vivo. 
  • An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation. 
  • Analysis of the binding specificities of oligomannoside-binding proteins using methylated monosaccharides. 
  • Antigen receptor control of methionine metabolism in T cells. 
  • Assessing 2'-O-Methylation of mRNA Using Quantitative PCR. 
  • Automated radiosynthesis of [11C]morphine for clinical investigation. 
  • BAHCC1 binds H3K27me3 via a conserved BAH module to mediate gene silencing and oncogenesis. 
  • Base stacking and molecular polarizability: effect of a methyl group in the 5-position of pyrimidines. 
  • Bat3 facilitates H3K79 dimethylation by DOT1L and promotes DNA damage-induced 53BP1 foci at G1/G2 cell-cycle phases. 
  • Benzodiazepine and beta-adrenergic receptor ligands independently stimulate phospholipid methylation. 
  • Beta adrenergic stimulation of protein carboxymethylation and amylase secretion in rat parotid gland. 
  • Bidirectional excision in methyl-directed mismatch repair. 
  • Blood biomarkers of methylation in Down syndrome and metabolic simulations using a mathematical model. 
  • Bovine serum albumin conformation on methyl and amine functionalized surfaces compared by scanning force microscopy. 
  • CD28 costimulatory signal induces protein arginine methylation in T cells. 
  • Catechol O-methyltransferase in red blood cells of schizophrenic, depressed, and normal human subjects. 
  • Caveolin-1 is down-regulated in human ovarian carcinoma and acts as a candidate tumor suppressor gene. 
  • Centromeric chromatin exhibits a histone modification pattern that is distinct from both euchromatin and heterochromatin. 
  • Changes in Neuroimmune and Neuronal Death Markers after Adolescent Alcohol Exposure in Rats are Reversed by Donepezil. 
  • Chemoattractant receptors on phagocytic cells. 
  • Clearance and binding of two electrophoretic "fast" forms of human alpha 2-macroglobulin. 
  • Clipping of arginine-methylated histone tails by JMJD5 and JMJD7. 
  • Codon usage regulates human KRAS expression at both transcriptional and translational levels. 
  • Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. 
  • Control of RhoA methylation by carboxylesterase I. 
  • Copper-catalyzed cyclization of steroidal acylaminoacetylenes: syntheses of novel 11beta-aryl-17,17- spiro[(4'H,5'-methylene)oxazol]-substituted steroids. 
  • Crystal structure of O4-methyl uridine: stacking induced changes in the geometry of the pyrimidine ring and its mutagenic role. 
  • Cyclic Alopecia and Abnormal Epidermal Cornification in Zdhhc13-Deficient Mice Reveal the Importance of Palmitoylation in Hair and Skin Differentiation. 
  • Cytochrome P1-450 structural gene in mouse, rat, and rabbit: differences in DNA methylation and developmental expression of mRNA. 
  • Cytosine methylation and suppression of O6-methylguanine-DNA methyltransferase expression in human rhabdomyosarcoma cell lines and xenografts. 
  • DNA CpG methylation inhibits binding of NF-kappa B proteins to the HIV-1 long terminal repeat cognate DNA motifs. 
  • DNA mismatch correction in a defined system. 
  • Demethylation of H3K27 Is Essential for the Induction of Direct Cardiac Reprogramming by miR Combo. 
  • Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. 
  • Desensitization and Incomplete Recovery of Hepatic Target Genes After Chronic Thyroid Hormone Treatment and Withdrawal in Male Adult Mice. 
  • Differences in Methadone Metabolism by CYP2B6 Variants. 
  • Distinct DNA methylation patterns characterize differentiated human embryonic stem cells and developing human fetal liver. 
  • Distinct and histone-specific modifications mediate positive versus negative transcriptional regulation of TSHalpha promoter. 
  • Dosage-response relationships for methyl methanesulfonate in Drosophila melanogaster spermatozoa: DNA methylation per nucleotide vs. sex-linked recessive lethal frequency. 
  • Dysregulation of multiple metabolic networks related to brain transmethylation and polyamine pathways in Alzheimer disease: A targeted metabolomic and transcriptomic study. 
  • EZH2 expression is associated with inferior overall survival in mantle cell lymphoma. 
  • Effects of a novel arginine methyltransferase inhibitor on T-helper cell cytokine production. 
  • Effects of high levels of DNA adenine methylation on methyl-directed mismatch repair in Escherichia coli. 
  • Efficient acquisition of high-resolution 4-D diagonal-suppressed methyl-methyl NOESY for large proteins. 
  • Epigenetics and psychostimulant addiction. 
  • Epitranscriptomic Addition of m5C to HIV-1 Transcripts Regulates Viral Gene Expression. 
  • Epitranscriptomic Enhancement of Influenza A Virus Gene Expression and Replication. 
  • Evidence that methylation of the FMR-I locus is responsible for variable phenotypic expression of the fragile X syndrome. 
  • Extent of equilibrium perturbation of the DNA helix upon enzymatic methylation of adenine residues. 
  • Facile synthesis of site-specifically acetylated and methylated histone proteins: reagents for evaluation of the histone code hypothesis. 
  • Fanconi Anemia FANCM/FNCM-1 and FANCD2/FCD-2 Are Required for Maintaining Histone Methylation Levels and Interact with the Histone Demethylase LSD1/SPR-5 in Caenorhabditis elegans . 
  • Gap formation is associated with methyl-directed mismatch correction under conditions of restricted DNA synthesis. 
  • Genomic mismatch scanning: a new approach to genetic linkage mapping. 
  • Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci. 
  • Heterogeneity of CYP3A isoforms metabolizing erythromycin and cortisol. 
  • Histidine-Dependent Protein Methylation Is Required for Compartmentalization of CTP Synthase. 
  • Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications. 
  • Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism. 
  • Histone demethylase AMX-1 is necessary for proper sensitivity to interstrand crosslink DNA damage. 
  • Histone lysine methyltransferase SDG8 is involved in brassinosteroid-regulated gene expression in Arabidopsis thaliana. 
  • Human enteric microsomal CYP4F enzymes O-demethylate the antiparasitic prodrug pafuramidine. 
  • Hypermethylated APC DNA in plasma and prognosis of patients with esophageal adenocarcinoma. 
  • Identification of an essential site for transcriptional activation within the human T-cell receptor delta enhancer. 
  • In vivo footprinting of the human alpha-globin locus upstream regulatory element by guanine and adenine ligation-mediated polymerase chain reaction. 
  • Increased Ca2+ -ATPase activity associated with methylation of phospholipids in human erythrocytes. 
  • Influence of HIV antiretrovirals on methadone N-demethylation and transport. 
  • Influence of threonine metabolism on S-adenosylmethionine and histone methylation. 
  • Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma. 
  • Initiation of methyl-directed mismatch repair. 
  • Insights into Watson-Crick/Hoogsteen breathing dynamics and damage repair from the solution structure and dynamic ensemble of DNA duplexes containing m1A. 
  • Interacting targets of the farnesyl of transducin gamma-subunit. 
  • Interaction of ethanol, cholesterol and vitamin A on phospholipid methylation in hepatic microsomes of rats. 
  • Isolation and characterization of the Escherichia coli mutH gene product. 
  • Isoprenylation of a protein kinase. Requirement of farnesylation/alpha-carboxyl methylation for full enzymatic activity of rhodopsin kinase. 
  • Isoprenylcysteine carboxyl methyltransferase deficiency in mice. 
  • KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation. 
  • Limits in the detection of m6A changes using MeRIP/m6A-seq. 
  • Lineage-specific compaction of Tcrb requires a chromatin barrier to protect the function of a long-range tethering element. 
  • Liver receptor homolog-1 is a critical determinant of methyl-pool metabolism. 
  • Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in Drosophila. 
  • Long-range function of secreted small nucleolar RNAs that direct 2'-O-methylation. 
  • Lysine-Specific Demethylase 1A (KDM1A/LSD1): Product Recognition and Kinetic Analysis of Full-Length Histones. 
  • Mass spectrometry of N-methylated peptide derivatives. 
  • Maternal one carbon metabolism and arsenic methylation in a pregnancy cohort in Mexico. 
  • Mathematical model insights into arsenic detoxification. 
  • Mathematical modeling of the effects of glutathione on arsenic methylation. 
  • Mechanism of autoinduction of methadone N-demethylation in human hepatocytes. 
  • Methed-up FOXOs can't in-Akt-ivate. 
  • Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width. 
  • Methionine metabolism is essential for SIRT1-regulated mouse embryonic stem cell maintenance and embryonic development. 
  • Methyl-directed DNA mismatch correction. 
  • Methyl-directed DNA mismatch repair in Escherichia coli. 
  • Methyl-directed mismatch repair is bidirectional. 
  • Methylation markers of malignant potential in meningiomas. 
  • Methylation of deoxycytidine incorporated by excision-repair synthesis of DNA. 
  • Methylation of histone H4 lysine 20 by PR-Set7 ensures the integrity of late replicating sequence domains in Drosophila. 
  • Methylation of mercury by bacteria exposed to dissolved, nanoparticulate, and microparticulate mercuric sulfides 
  • Mispair specificity of methyl-directed DNA mismatch correction in vitro. 
  • Modification of messenger RNA by 2'-O-methylation regulates gene expression in vivo. 
  • Molecular analysis of P16(Ink4)/CDKN2 and P15(INK4B)/MTS2 genes in primary human testicular germ cell tumors. 
  • Molecular profile and copy number analysis of sporadic colorectal cancer in Taiwan. 
  • Mouse embryonic germ (EG) cell lines: transmission through the germline and differences in the methylation imprint of insulin-like growth factor 2 receptor (Igf2r) gene compared with embryonic stem (ES) cell lines. 
  • Mutation detection with MutH, MutL, and MutS mismatch repair proteins. 
  • N-methylated 5-alkenyloxazolium salt transformations. 
  • N6-methyladenosine is required for the hypoxic stabilization of specific mRNAs. 
  • NIP45 controls the magnitude of the type 2 T helper cell response. 
  • Net methylation of mercury in estuarine sediment microcosms amended with dissolved, nanoparticulate, and microparticulate mercuric sulfides. 
  • Novel RNA modifications in the nervous system: form and function. 
  • One-carbon metabolism and epigenetics: understanding the specificity. 
  • One-methyl group metabolism in non-ketotic hyperglycinaemia: mildly elevated cerebrospinal fluid homocysteine levels. 
  • Parent-specific expression of a human keratin 18/beta-galactosidase fusion gene in transgenic mice. 
  • Parental methylation mediates how progeny respond to environments of parents and of progeny themselves. 
  • Perturbations in S-adenosylhomocysteine and S-adenosylmethionine metabolism: effects on transmethylation. 
  • Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. 
  • Phosphatidylcholine metabolism in lung microsomes and lung surfactant of rats exposed intratracheally to coal fly ash. 
  • Phospholipid methylation in macrophages is inhibited by chemotactic factors. 
  • Phospholipid methylation unmasks cryptic beta-adrenergic receptors in rat reticulocytes. 
  • Phospholipid methylation: a possible mechanism of signal transduction across biomembranes. 
  • Polymorphism and altered methylation of the lactoferrin gene in normal leukocytes, leukemic cells, and breast cancer. 
  • Processing of nuclear heterogeneous RNA: recent developments. 
  • Protein Arginine Methyltransferase 5 Promotes pICln-Dependent Androgen Receptor Transcription in Castration-Resistant Prostate Cancer. 
  • Proteomic dissection of LPS-inducible, PHF8-dependent secretome reveals novel roles of PHF8 in TLR4-induced acute inflammation and T cell proliferation. 
  • Quantification of Mercury Bioavailability for Methylation Using Diffusive Gradient in Thin-Film Samplers. 
  • RHO methylation matters: a role for isoprenylcysteine carboxylmethyltransferase in cell migration and adhesion. 
  • RNA polymerase-associated interactions near template promoter sequences of defective interfering particles of vesicular stomatitis virus. 
  • Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation. 
  • Regulation of beta-adrenergic receptors by phospholipid methylation. 
  • Regulation of mononuclear leukocyte function by transmethylation reactions. 
  • Regulation of the beta-adrenergic receptor by methylation of membrane phospholipids. 
  • Relative contributions of mercury bioavailability and microbial growth rate on net methylmercury production by anaerobic mixed cultures. 
  • Removal of N-6-methyladenine by the nucleotide excision repair pathway triggers the repair of mismatches in yeast gap-repair intermediates. 
  • Reprogrammed marrow adipocytes contribute to myeloma-induced bone disease. 
  • Requirement for d(GATC) sequences in Escherichia coli mutHLS mismatch correction. 
  • Requirement of S-adenosyl-L-methionine-mediated methylation for human monocyte chemotaxis. 
  • Retinoic acid receptor-beta2 promoter methylation in random periareolar fine needle aspiration. 
  • Role of isoprenylcysteine carboxylmethyltransferase-catalyzed methylation in Rho function and migration. 
  • Role of transmethylation reactions in cellular motility and phagocytosis. 
  • S-adenosylhomocysteine toxicity in normal and adenosine kinase-deficient lymphoblasts of human origin. 
  • SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis. 
  • Salmonella typhimurium SA host specificity system is based on deoxyribonucleic acid-adenine methylation. 
  • Sequence-specific contacts between the RNA polymerase of vesicular stomatitis virus and the leader RNA gene. 
  • Serine, glycine and one-carbon units: cancer metabolism in full circle. 
  • Single-molecule FRET reveals multiscale chromatin dynamics modulated by HP1α. 
  • Steroids. LXXIX. Synthesis and reactions of oxiranes obtained from 3- and 17-keto steroids. 
  • Structure-guided DOT1L probe optimization by label-free ligand displacement. 
  • Studies on sequence recognition by type II restriction and modification enzymes. 
  • Studies on the mechanism of the synergistic interaction between 2'-deoxy-5-azacytidine and cisplatin. 
  • Survival Outcomes of Elderly Patients With Glioblastoma Multiforme in Their 75th Year or Older Treated With Adjuvant Therapy. 
  • Synergistic cytotoxicity using 2'-deoxy-5-azacytidine and cisplatin or 4-hydroperoxycyclophosphamide with human tumor cells. 
  • Synergistic cytotoxicity with 2'-deoxy-5-azacytidine and topotecan in vitro and in vivo. 
  • TP53 genomic status regulates sensitivity of gastric cancer cells to the histone methylation inhibitor 3-deazaneplanocin A (DZNep). 
  • Targeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation. 
  • Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate. 
  • Targeting the histone methyltransferase G9a activates imprinted genes and improves survival of a mouse model of Prader-Willi syndrome. 
  • The C-terminal polylysine region and methylation of K-Ras are critical for the interaction between K-Ras and microtubules. 
  • The COOH-terminal domain of the Rap1A (Krev-1) protein is isoprenylated and supports transformation by an H-Ras:Rap1A chimeric protein. 
  • The Histone Methyltransferase Ash1l is Required for Epidermal Homeostasis in Mice. 
  • The dynamic epitranscriptome: N6-methyladenosine and gene expression control. 
  • The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry. 
  • The genetic landscape of the childhood cancer medulloblastoma. 
  • The genomic landscape of mantle cell lymphoma is related to the epigenetically determined chromatin state of normal B cells. 
  • The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote. 
  • The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy. 
  • The mRNA Cap 2'-O-Methyltransferase CMTR1 Regulates the Expression of Certain Interferon-Stimulated Genes. 
  • The metabolic fate of independently initiated VSV mRNA transcripts. 
  • The relationship between intracellular and plasma levels of folate and metabolites in the methionine cycle: a model. 
  • The role of transmethylation reactions in regulating the binding of BCG-activated murine macrophages to neoplastic target cells. 
  • Total-body creatine pool size and skeletal muscle mass determination by creatine-(methyl-D3) dilution in rats. 
  • Transcriptome-Wide Identification of 2'-O-Methylation Sites with RibOxi-Seq. 
  • Transductional mechanisms of chemoattractant receptors on leukocytes. 
  • Transmethylation reactions are required for initial morphologic and biochemical responses of human monocytes to chemoattractants. 
  • Transmethylation reactions regulate affinity and functional activity of chemotactic factor receptors on macrophages. 
  • Two Ck1δ transcripts regulated by m6A methylation code for two antagonistic kinases in the control of the circadian clock. 
  • Utility of Diffusive Gradient in Thin-Film Passive Samplers for Predicting Mercury Methylation Potential and Bioaccumulation in Freshwater Wetlands. 
  • X-chromosome hyperactivation in mammals via nonlinear relationships between chromatin states and transcription. 
  • beta-Adrenergic receptor agonists increase phospholipid methylation, membrane fluidity, and beta-adrenergic receptor-adenylate cyclase coupling. 
  • scDART-seq reveals distinct m6A signatures and mRNA methylation heterogeneity in single cells. 
  • trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Deshusses, Marc, Professor of Civil and Environmental Engineering, Nicholas Institute-Energy Initiative
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • Hsu-Kim, Heileen, Professor in the Department of Civil and Environmental Engineering, Civil and Environmental Engineering
  • Jiang, Rong, Assistant Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences
  • McLendon, Roger Edwin, Professor of Pathology, Pathology