Methyltransferases

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  Subject Areas on Research

  • A chemical method for labeling lysine methyltransferase substrates. 
  • A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes. 
  • A novel domain in Set2 mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation. 
  • A phase 1 trial of the oral DNA methyltransferase inhibitor CC-486 and the histone deacetylase inhibitor romidepsin in advanced solid tumors. 
  • Activity of temozolomide in the treatment of central nervous system tumor xenografts. 
  • Adding pharmacogenetics information to drug labels: lessons learned. 
  • Bat3 facilitates H3K79 dimethylation by DOT1L and promotes DNA damage-induced 53BP1 foci at G1/G2 cell-cycle phases. 
  • Benzodiazepine and beta-adrenergic receptor ligands independently stimulate phospholipid methylation. 
  • Betaine-homocysteine methyltransferase is a developmentally regulated enzyme crystallin in rhesus monkey lens. 
  • Calcineurin is essential for survival during membrane stress in Candida albicans. 
  • Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors. 
  • Cell surface polarization during yeast mating. 
  • Characterization of cDNA encoding mouse DNA repair protein O6-methylguanine-DNA methyltransferase and high-level expression of the wild-type and mutant proteins in Escherichia coli. 
  • Characterization of mediators of insulin action. 
  • Conservation and functional importance of carbon-oxygen hydrogen bonding in AdoMet-dependent methyltransferases. 
  • Cooperative role of AtRsmD and AtRimM proteins in modification and maturation of 16S rRNA in plastids. 
  • Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment. 
  • Cyclopropane Modification of Trehalose Dimycolate Drives Granuloma Angiogenesis and Mycobacterial Growth through Vegf Signaling. 
  • Cytosine methylation and suppression of O6-methylguanine-DNA methyltransferase expression in human rhabdomyosarcoma cell lines and xenografts. 
  • Developmental exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin alters DNA methyltransferase (dnmt) expression in zebrafish (Danio rerio). 
  • Direct RNA sequencing reveals m6A modifications on adenovirus RNA are necessary for efficient splicing. 
  • EcoRI methylase. Physical and catalytic properties of the homogeneous enzyme. 
  • Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme. 
  • Epigenetic STING silencing is developmentally conserved in gliomas and can be rescued by methyltransferase inhibition. 
  • Epitranscriptomic Addition of m5C to HIV-1 Transcripts Regulates Viral Gene Expression. 
  • Erg6 affects membrane composition and virulence of the human fungal pathogen Cryptococcus neoformans. 
  • Escherichia coli K-12 clones that overproduce dam methylase are hypermutable. 
  • Escherichia coli dam methylase. Physical and catalytic properties of the homogeneous enzyme. 
  • Expanding the functional repertoire of CTD kinase I and RNA polymerase II: novel phosphoCTD-associating proteins in the yeast proteome. 
  • Expression of O6-alkylguanine-DNA alkyltransferase in Mer+ and Mer- human cell extracts probed with specific monoclonal antibodies. 
  • Expression of O6-methylguanine-DNA methyltransferase in malignant human glioma cell lines. 
  • Expression of O6-methylguanine-DNA methyltransferase in six human medulloblastoma cell lines. 
  • Extensive Epitranscriptomic Methylation of A and C Residues on Murine Leukemia Virus Transcripts Enhances Viral Gene Expression. 
  • Extent of equilibrium perturbation of the DNA helix upon enzymatic methylation of adenine residues. 
  • FTO Suppresses STAT3 Activation and Modulates Proinflammatory Interferon-Stimulated Gene Expression. 
  • Genetic variation in glutathione S-transferase omega-1, arsenic methyltransferase and methylene-tetrahydrofolate reductase, arsenic exposure and bladder cancer: a case-control study. 
  • Genomic mismatch scanning: a new approach to genetic linkage mapping. 
  • High-level expression of Escherichia coli NADPH-sulfite reductase: requirement for a cloned cysG plasmid to overcome limiting siroheme cofactor. 
  • Human CD34+ hematopoietic progenitors have low, cytokine-unresponsive O6-alkylguanine-DNA alkyltransferase and are sensitive to O6-benzylguanine plus BCNU. 
  • Identification of nitrosourea-resistant human rhabdomyosarcomas by in situ immunostaining of O6-methylguanine-DNA methyltransferase. 
  • Immunoaffinity purification of human O6-alkylguanine-DNA alkyltransferase using newly developed monoclonal antibodies. 
  • Immunosuppressant target protein FKBP12 is required for P-glycoprotein function in yeast. 
  • Intracellular mediators of insulin action. 
  • Isolation of gram quantities of EcoRI restriction and modification enzymes from an overproducing strain. 
  • JMJD6 cleaves MePCE to release positive transcription elongation factor b (P-TEFb) in higher eukaryotes. 
  • Karyotypic abnormalities create discordance of germline genotype and cancer cell phenotypes. 
  • Long-Range Allosteric Interactions between the Folate and Methionine Cycles Stabilize DNA Methylation Reaction Rate 
  • Loss of betaglycan expression in ovarian cancer: role in motility and invasion. 
  • Manipulating unconventional CH-based hydrogen bonding in a methyltransferase via noncanonical amino acid mutagenesis. 
  • Mapping of m6A and Its Regulatory Targets in Prostate Cancer Reveals a METTL3-Low Induction of Therapy Resistance. 
  • Mathematical analysis of the regulation of competing methyltransferases. 
  • Metabolism of O6-benzylguanine, an inactivator of O6-alkylguanine-DNA alkyltransferase. 
  • Methyl-directed DNA mismatch repair in Escherichia coli. 
  • Methylator resistance mediated by mismatch repair deficiency in a glioblastoma multiforme xenograft. 
  • Methyltransferase inhibitors restore SATB1 protective activity against cutaneous T cell lymphoma in mice. 
  • Modification of messenger RNA by 2'-O-methylation regulates gene expression in vivo. 
  • Modulation of O6-alkylguanine-DNA alkyltransferase-mediated carmustine resistance using streptozotocin: a phase I trial. 
  • Multicentre surveillance of the prevalence and molecular epidemiology of macrolide resistance among pharyngeal isolates of group A streptococci in the USA. 
  • N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. 
  • N6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein. 
  • NMR assignment of the SRI domain of human Set2/HYPB. 
  • Nucleosome Turnover Regulates Histone Methylation Patterns over the Genome. 
  • O6-alkylguanine-DNA alkyltransferase and sensitivity to procarbazine in human brain-tumor xenografts. 
  • PGC-1alpha mRNA expression is influenced by metabolic perturbation in exercising human skeletal muscle. 
  • Partial NH2- and cooh-terminal sequence analyses of Eco RI DNA restriction and modification enzymes. 
  • Pax3/7BP is a Pax7- and Pax3-binding protein that regulates the proliferation of muscle precursor cells by an epigenetic mechanism. 
  • Phospholipid methylation unmasks cryptic beta-adrenergic receptors in rat reticulocytes. 
  • Phospholipid methylation: a possible mechanism of signal transduction across biomembranes. 
  • Post-transcriptional regulation of antiviral gene expression by N6-methyladenosine. 
  • Production and characterization of antipeptide antibodies against human O6-methylguanine-DNA methyltransferase. 
  • RNA-dependent stabilization of SUV39H1 at constitutive heterochromatin. 
  • Recognition sequence of the dam methylase of Escherichia coli K12 and mode of cleavage of Dpn I endonuclease. 
  • Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation. 
  • Regulation of beta-adrenergic receptors by phospholipid methylation. 
  • Regulation of the beta-adrenergic receptor by methylation of membrane phospholipids. 
  • Role of the 2-amino group of deoxyguanosine in sequence recognition by EcoRI restriction and modification enzymes. 
  • Site-specific methylases induce the SOS DNA repair response in Escherichia coli. 
  • Solution structure of the Set2-Rpb1 interacting domain of human Set2 and its interaction with the hyperphosphorylated C-terminal domain of Rpb1. 
  • Structural Basis for Recognition of Ubiquitylated Nucleosome by Dot1L Methyltransferase. 
  • Structural and Functional Characterization of Sulfonium Carbon-Oxygen Hydrogen Bonding in the Deoxyamino Sugar Methyltransferase TylM1. 
  • Structural and immunological comparison of indigenous human O6-methylguanine-DNA methyltransferase with that encoded by a cloned cDNA. 
  • Structure-guided DOT1L probe optimization by label-free ligand displacement. 
  • Structures of the m(6)A Methyltransferase Complex: Two Subunits with Distinct but Coordinated Roles. 
  • Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers. 
  • Targeted inhibition of V(D)J recombination by a histone methyltransferase. 
  • The dynamic epitranscriptome: N6-methyladenosine and gene expression control. 
  • The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry. 
  • The histone methylase Set2p and the histone deacetylase Rpd3p repress meiotic recombination at the HIS4 meiotic recombination hotspot in Saccharomyces cerevisiae. 
  • The mRNA Cap 2'-O-Methyltransferase CMTR1 Regulates the Expression of Certain Interferon-Stimulated Genes. 
  • The origin of O6-methylguanine-DNA methyltransferase in Chinese hamster ovary cells transfected with human DNA. 
  • The role of transmethylation reactions in regulating the binding of BCG-activated murine macrophages to neoplastic target cells. 
  • Therapeutic analysis of melphalan-resistant human rhabdomyosarcoma xenograft TE-671 MR. 
  • Treatment of subcutaneous and intracranial brain tumor xenografts with O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea. 
  • Two Ck1δ transcripts regulated by m6A methylation code for two antagonistic kinases in the control of the circadian clock. 
  • Ubiquitination-dependent proteolysis of O6-methylguanine-DNA methyltransferase in human and murine tumor cells following inactivation with O6-benzylguanine or 1,3-bis(2-chloroethyl)-1-nitrosourea. 
  • Understanding the state of pharmacogenomic testing for thiopurine methyltransferase within a large health system. 
  • Using pharmacogenetics to improve drug safety and efficacy. 
  • Utility of thiopurine methyltransferase genotyping and phenotyping, and measurement of azathioprine metabolites in the management of patients with autoimmune hepatitis. 
  • WTAP Targets the METTL3 m6A-Methyltransferase Complex to Cytoplasmic Hepatitis C Virus RNA to Regulate Infection. 
  • m6A and YTHDF proteins contribute to the localization of select neuronal mRNAs. 
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  Keywords of People

  • Guan, Ziqiang, Research Professor in Biochemistry, Biochemistry
  • Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Integrative Immunobiology