Mevalonic Acid

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  Subject Areas on Research

  • A case report of mevalonate kinase deficiency in a 14-month-old female with fevers and lower extremity weakness. 
  • Cilia loss sensitizes cells to transformation by activating the mevalonate pathway. 
  • Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: evidence for non-canonical activation of RhoA and Rac1 GTPases. 
  • G protein gamma subunits contain a 20-carbon isoprenoid. 
  • Growth inhibitory effects of aromatic fatty acids on ovarian tumor cell lines. 
  • Isoprenylation of a protein kinase. Requirement of farnesylation/alpha-carboxyl methylation for full enzymatic activity of rhodopsin kinase. 
  • Isoprenylation of the low molecular mass GTP-binding proteins rac 1 and rac 2: possible role in membrane localization. 
  • Role of small GTP-binding proteins in lovastatin-induced cataracts. 
  • Statin therapy inhibits fatty acid synthase via dynamic protein modifications. 
  • Toxicity of oxidized low density lipoproteins for vascular smooth muscle cells and partial protection by antioxidants. 
  • p21ras is modified by a farnesyl isoprenoid.