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Subject Areas on Research
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(4-[18F]fluoro-3-iodobenzyl)guanidine, a potential MIBG analogue for positron emission tomography.
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1-(m-[211At]astatobenzyl)guanidine: synthesis via astato demetalation and preliminary in vitro and in vivo evaluation.
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2-O, 3-O-desulfated heparin inhibits neutrophil elastase-induced HMGB-1 secretion and airway inflammation.
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211At- and 131I-labeled bisphosphonates with high in vivo stability and bone accumulation.
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3-[211At]astato-4-fluorobenzylguanidine: a potential therapeutic agent with prolonged retention by neuroblastoma cells.
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3He MRI in mouse models of asthma.
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5α-Reductase inhibition coupled with short off cycles increases survival in the LNCaP xenograft prostate tumor model on intermittent androgen deprivation therapy.
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A 4-methyl-substituted meta-iodobenzylguanidine analogue with prolonged retention in human neuroblastoma cells.
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A Sch9 protein kinase homologue controlling virulence independently of the cAMP pathway in Cryptococcus neoformans.
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A Single Immunization with Nucleoside-Modified mRNA Vaccines Elicits Strong Cellular and Humoral Immune Responses against SARS-CoV-2 in Mice.
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A comparison of antiangiogenic therapies for the prevention of liver metastases.
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A comparison of murine T-cell-depleted adult bone marrow and full-term fetal blood cells in hematopoietic engraftment and immune reconstitution.
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A genetically tractable model of human glioma formation.
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A high-performance liquid chromatography method for the quantification of cysmethynil, an inhibitor of isoprenylcysteine carboxylmethyl transferase, in mouse plasma.
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A local hyperthermia treatment which enhances antibody uptake in a glioma xenograft model does not affect tumour interstitial fluid pressure.
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A manganese porphyrin superoxide dismutase mimetic enhances tumor radioresponsiveness.
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A monoclonal antibody IMab-1 specifically recognizes IDH1R132H, the most common glioma-derived mutation.
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A monoclonal antibody reactive with a second epitope of the 67,000-dalton human T cell antigen.
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A murine model for short-chain acyl-CoA dehydrogenase deficiency.
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A murine monoclonal antibody directed against the carboxyl-terminal domain of GRP78 suppresses melanoma growth in mice.
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A mutation in a mitochondrial transmembrane protein is responsible for the pleiotropic hematological and skeletal phenotype of flexed-tail (f/f) mice.
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A novel conditionally replicating "armed" adenovirus selectively targeting gastrointestinal tumors with aberrant wnt signaling.
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A novel method for viral gene delivery in solid tumors.
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A novel murine oncornavirus with dual eco- and xenotropic properties.
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A novel rodent mammary window of orthotopic breast cancer for intravital microscopy.
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A novel toll-like receptor 9 agonist cooperates with trastuzumab in trastuzumab-resistant breast tumors through multiple mechanisms of action.
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A quantitative trait locus (LSq-1) on mouse chromosome 7 is linked to the absence of tissue loss after surgical hindlimb ischemia.
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A role for fractalkine and its receptor (CX3CR1) in cardiac allograft rejection.
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A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase.
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A sensitized mutagenesis screen identifies Gli3 as a modifier of Sox10 neurocristopathy.
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A small regulatory element from chromosome 19 enhances liver-specific gene expression.
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A study of dendritic and endothelial cell interactions in colon cancer in a cell line and small mammal model.
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A synthetic random basic copolymer with promiscuous binding to class II major histocompatibility complex molecules inhibits T-cell proliferative responses to major and minor histocompatibility antigens in vitro and confers the capacity to prevent murine graft-versus-host disease in vivo.
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A targeted and adjuvanted nanocarrier lowers the effective dose of liposomal amphotericin B and enhances adaptive immunity in murine cutaneous leishmaniasis.
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A transcriptional signature accurately identifies Aspergillus Infection across healthy and immunosuppressed states.
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A two-phase innate host response to alphavirus infection identified by mRNP-tagging in vivo.
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A unique chromosomal rearrangement in the Cryptococcus neoformans var. grubii type strain enhances key phenotypes associated with virulence.
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A unique pathway for the plasma elimination of alpha 2-antiplasmin-protease complexes in mice.
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A20 protects mice from D-galactosamine/lipopolysaccharide acute toxic lethal hepatitis.
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A20 protects mice from lethal liver ischemia/reperfusion injury by increasing peroxisome proliferator-activated receptor-alpha expression.
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ADAM12: a genetic modifier of preclinical peripheral arterial disease.
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APOL1-G0 protects podocytes in a mouse model of HIV-associated nephropathy.
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Aberrant methylation and loss of CADM2 tumor suppressor expression is associated with human renal cell carcinoma tumor progression.
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Absence of donor MHC antigen expression ameliorates chronic kidney allograft rejection.
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Activation and repression of mammalian gene expression by the c-myc protein.
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Activation of interleukin 4- and interleukin 6-secreting cells by HIV-specific synthetic peptides.
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Active immunization using dendritic cells mixed with tumor cells inhibits the growth of primary breast cancer.
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Active immunotherapy with transiently transfected cytokine-secreting tumor cells inhibits breast cancer metastases in tumor-bearing animals.
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Activity of 9-dimethylaminomethyl-10-hydroxycamptothecin against pediatric and adult central nervous system tumor xenografts.
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Activity of and effect of subcutaneous treatment with the broad-spectrum antiviral lectin griffithsin in two laboratory rodent models.
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Activity of irofulven (6-hydroxymethylacylfulvene) in the treatment of glioblastoma multiforme-derived xenografts in athymic mice.
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Activity of temozolomide in the treatment of central nervous system tumor xenografts.
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Acute ethanol administration downregulates human immunodeficiency virus-1 glycoprotein 120-induced KC and RANTES production by murine Kupffer cells and splenocytes.
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Acute joint pathology and synovial inflammation is associated with increased intra-articular fracture severity in the mouse knee.
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Addition of a second, different allogeneic graft accelerates white cell and platelet engraftment after T-cell-depleted bone marrow transplantation.
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Addressing cell-sourcing limitations with gene therapy.
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Adeno-associated virus type 2 contains an integrin alpha5beta1 binding domain essential for viral cell entry.
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Adjuvanticity and protective immunity of Plasmodium yoelii nigeriensis blood-stage soluble antigens encapsulated in fusogenic liposome.
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Administration of a CD31-derived peptide delays the onset and significantly increases survival from lethal graft-versus-host disease.
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Adoptively transferred ex vivo expanded gammadelta-T cells mediate in vivo antitumor activity in preclinical mouse models of breast cancer.
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Aerobic exercise attenuates airway inflammatory responses in a mouse model of atopic asthma.
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Aggresome disruption: a novel strategy to enhance bortezomib-induced apoptosis in pancreatic cancer cells.
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Aging and reactivation of latent murine cytomegalovirus.
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Airway epithelial progenitors are region specific and show differential responses to bleomycin-induced lung injury.
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Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis.
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Alginate encapsulation is a highly reproducible method for tumor cell implantation in dorsal skinfold chambers.
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Allergen-induced airway disease is mouse strain dependent.
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Alpha-chemokine receptor blockade reduces high mobility group box 1 protein-induced lung inflammation and injury and improves survival in sepsis.
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Alpha-melanocyte-stimulating hormone suppresses antigen-stimulated T cell production of gamma-interferon.
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Alphavirus replicon particles acting as adjuvants promote CD8+ T cell responses to co-delivered antigen.
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Altered intragraft immune responses and improved renal function in MHC class II-deficient mouse kidney allografts.
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Alternative splicing of fibroblast growth factor receptor 2 (FGF-R2) in human prostate cancer.
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Alveolar macrophage apoptosis and TNF-alpha, but not p53, expression correlate with murine response to bleomycin.
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Amplification and expression of the epidermal growth factor receptor gene in human glioma xenografts.
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An entirely cell-based system to generate single-chain antibodies against cell surface receptors.
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An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype.
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An unbiased in vivo functional genomics screening approach in mice identifies novel tumor cell-based regulators of immune rejection.
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Analysis of a food-borne fungal pathogen outbreak: virulence and genome of a Mucor circinelloides isolate from yogurt.
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Analysis of the globose basal cell compartment in rat olfactory epithelium using GBC-1, a new monoclonal antibody against globose basal cells.
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Ancestral and consensus envelope immunogens for HIV-1 subtype C.
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Angiostatin-like activity of a monoclonal antibody to the catalytic subunit of F1F0 ATP synthase.
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Angiotensin II plays a role in acute murine experimental autoimmune cystitis.
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Anti-DNA antibodies form immune deposits at distinct glomerular and vascular sites.
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Anti-EGFRvIII monoclonal antibody armed with 177Lu: in vivo comparison of macrocyclic and acyclic ligands.
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Anti-TCR mAb induces peripheral tolerance to alloantigens and delays islet allograft rejection in autoimmune diabetic NOD mice.
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Anti-U1A monoclonal antibodies recognize unique epitope targets of U1A which are involved in the binding of U1 RNA.
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Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration.
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Anti-angiogenesis effect of the novel anti-inflammatory and pro-resolving lipid mediators.
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Anti-angiogenic effects of interleukin-12 delivered by a novel hyperthermia induced gene construct.
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Anti-glycoprotein D monoclonal antibody protects against herpes simplex virus type 1-induced diseases in mice functionally depleted of selected T-cell subsets or asialo GM1+ cells.
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Anti-idiotypic monoclonal antibodies to GM1 identify ganglioside binding proteins.
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Anti-intercellular adhesion molecule-1 antibody and intercellular adhesion molecule-1 gene deficiency do not prevent pulmonary neutrophil recruitment in polymicrobial sepsis.
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Anti-mouse mesangial cell serum induces acute glomerulonephropathy in mice.
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Anti-receptor antibody-induced suppression of murine H-Y-specific delayed-type hypersensitivity responses.
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Antiadhesive properties of a quaternary structure-specific hybridoma antibody against type 1 fimbriae of Escherichia coli.
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Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP(5+), via suppression of oxidative stress in a mouse model of breast tumor.
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Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2.
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Antibodies to Trichomonas vaginalis surface glycolipid.
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Antibody alone does not prevent experimental cytomegalovirus retinitis in mice with retrovirus-induced immunodeficiency (MAIDS).
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Antibody-mediated B-cell depletion before adoptive immunotherapy with T cells expressing CD20-specific chimeric T-cell receptors facilitates eradication of leukemia in immunocompetent mice.
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Anticancer therapeutic potential of Mn porphyrin/ascorbate system.
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Antiepidermal growth factor variant III scFv fragment: effect of radioiodination method on tumor targeting and normal tissue clearance.
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Antigen processing in vivo and the elicitation of primary CTL responses.
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Antigenicity and immunogenicity of a synthetic human immunodeficiency virus type 1 group m consensus envelope glycoprotein.
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Antiproliferative effects of cyclocreatine on human prostatic carcinoma cells.
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Antitenascin antibody 81C6 armed with 177Lu: in vivo comparison of macrocyclic and acyclic ligands.
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Antiviral Effects of ABMA against Herpes Simplex Virus Type 2 In Vitro and In Vivo.
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Antiviral effects of Retro-2cycl and Retro-2.1 against Enterovirus 71 in vitro and in vivo.
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Aquaporin in Candida: characterization of a functional water channel protein.
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Association of age-dependent liver injury and fibrosis with immune cell populations.
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Astatine-211 labeling of internalizing anti-EGFRvIII monoclonal antibody using N-succinimidyl 5-[211At]astato-3-pyridinecarboxylate.
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Astatine-211-labeled biotin conjugates resistant to biotinidase for use in pretargeted radioimmunotherapy.
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Ataxia telangiectasia-mutated and p53 are potential mediators of chloroquine-induced resistance to mammary carcinogenesis.
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Attenuation of herpes simplex virus neurovirulence with picornavirus cis-acting genetic elements.
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Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice.
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Autocrine stimulation of mas oncogene leads to altered growth control.
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B cell maintenance of subcapsular sinus macrophages protects against a fatal viral infection independent of adaptive immunity.
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B lymphocytes differentially influence acute and chronic allograft rejection in mice.
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BAG3 (Bcl-2-Associated Athanogene-3) Coding Variant in Mice Determines Susceptibility to Ischemic Limb Muscle Myopathy by Directing Autophagy.
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BET Bromodomain Inhibitors Which Permit Treg Function Enable a Combinatorial Strategy to Suppress GVHD in Pre-clinical Allogeneic HSCT.
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BRAF Inhibition Stimulates Melanoma-Associated Macrophages to Drive Tumor Growth.
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Bacterial penetration of bladder epithelium through lipid rafts.
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Bevacizumab, irinotecan, temozolomide, tyrosine kinase inhibition, and MEK inhibition are effective against pleomorphic xanthoastrocytoma regardless of V600E status.
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Bevacizumab-induced alterations in vascular permeability and drug delivery: a novel approach to augment regional chemotherapy for in-transit melanoma.
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Biodistribution of O6-benzylguanine and its effectiveness against human brain tumor xenografts when given in polyethylene glycol or cremophor-EL.
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Biological evaluation of ring- and side-chain-substituted m-iodobenzylguanidine analogues.
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Biology of hepatocellular neoplasia in the mouse. I. Histogenesis of safrole-induced hepatocellular carcinoma.
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Biology of hepatocellular neoplasia in the mouse. II. Sequential enzyme histochemical analysis of BALB/c mouse liver during safrole-induced carcinogenesis.
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Biology of hepatocellular neoplasia in the mouse. III. Electron microscopy of safrole-induced hepatocellular adenomas and hepatocellular carcinomas.
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Bioluminescent virion shells: new tools for quantitation of AAV vector dynamics in cells and live animals.
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Bisphosphonates target B cells to enhance humoral immune responses.
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Blockade of T- and B-lymphocyte development by antibody to the gamma c subunit of the receptors for interleukins 2, 4, and 7.
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Blocking [211At]astatide accumulation in normal tissues: preliminary evaluation of seven potential compounds.
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Blood gene expression signatures predict invasive candidiasis.
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Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute T helper type 1 immune responses.
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Bmp6 regulates retinal iron homeostasis and has altered expression in age-related macular degeneration.
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Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosis.
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Brachytherapy using injectable seeds that are self-assembled from genetically encoded polypeptides in situ.
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Brain tumors in mice are susceptible to blockade of epidermal growth factor receptor (EGFR) with the oral, specific, EGFR-tyrosine kinase inhibitor ZD1839 (iressa).
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Bromelain treatment decreases neutrophil migration to sites of inflammation.
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Bronchus-associated lymphoid tissue-resident Foxp3+ T lymphocytes prevent antibody-mediated lung rejection.
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Buthionine sulfoximine-mediated depletion of glutathione in intracranial human glioma-derived xenografts.
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CCL-21 conditioned regulatory T cells induce allotolerance through enhanced homing to lymphoid tissue.
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CCR2+ monocyte-derived dendritic cells and exudate macrophages produce influenza-induced pulmonary immune pathology and mortality.
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CD11c(+)B220(+)Gr-1(+) cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells.
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CD19 expression in B cells is important for suppression of contact hypersensitivity.
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CD22 expression mediates the regulatory functions of peritoneal B-1a cells during the remission phase of contact hypersensitivity reactions.
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CD26 inhibition enhances allogeneic donor-cell homing and engraftment after in utero hematopoietic-cell transplantation.
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CD62L- memory T cells enhance T-cell regeneration after allogeneic stem cell transplantation by eliminating host resistance in mice.
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CD8 positive T cells influence antigen-specific immune responses through the expression of chemokines.
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CXCR4 enhances adhesion of B16 tumor cells to endothelial cells in vitro and in vivo via beta(1) integrin.
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Calcineurin is essential for Candida albicans survival in serum and virulence.
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Calcineurin promotes infection of the cornea by Candida albicans and can be targeted to enhance fluconazole therapy.
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Caloric restriction augments radiation efficacy in breast cancer.
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Capric acid and hydroxypropylmethylcellulose increase the immunogenicity of nasally administered peptide vaccines.
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Carcinogen induced unscheduled DNA synthesis in mouse hepatocytes.
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Casein kinase 1α-dependent feedback loop controls autophagy in RAS-driven cancers.
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Celecoxib inhibits vascular endothelial growth factor expression in and reduces angiogenesis and metastasis of human pancreatic cancer via suppression of Sp1 transcription factor activity.
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Cell binding and tumor inhibiting functions of a new antihuman melanoma murine monoclonal antibody.
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Cell-Type-Specific Optical Recording of Membrane Voltage Dynamics in Freely Moving Mice.
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Cell-mediated immune responses to vaccine peptides derived from the circumsporozoite protein of Plasmodium falciparum.
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Cells en route to apoptosis are characterized by the upregulation of c-fos, c-myc, c-jun, cdc2, and RB phosphorylation, resembling events of early cell-cycle traverse.
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Central tolerance regulates B cells reactive with Goodpasture antigen alpha3(IV)NC1 collagen.
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Characterization and regulation of the trehalose synthesis pathway and its importance in the pathogenicity of Cryptococcus neoformans.
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Characterization of a CD6 ligand(s) expressed on human- and murine-derived cell lines and murine lymphoid tissues.
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Characterization of a monoclonal antibody (5E9) that defines a human cell surface antigen of cell activation.
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Characterization of a murine monoclonal antibody that mimics heparin-induced thrombocytopenia antibodies.
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Characterization of cDNA encoding mouse DNA repair protein O6-methylguanine-DNA methyltransferase and high-level expression of the wild-type and mutant proteins in Escherichia coli.
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Characterization of cytotoxic cells generated from in vitro cultures of murine bone marrow cells.
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Characterization of intraocular immunopathology following intracameral inoculation with alloantigen.
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Characterization of monoclonal antibodies with specificity for DNA and the synthetic polypeptide antigen (T,G)-A-L.
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Characterization of murine carcinoembryonic antigen gene family members.
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Characterization of neuronal/glial differentiation of murine adipose-derived adult stromal cells.
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Characterization of new gangliosides of the lactotetraose series in murine xenografts of a human glioma cell line.
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Characterization of the immune response to the major glycoprotein (gp 71) of Friend leukemia virus. I. Response in BALB/c mice.
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Characterization of the mechanisms of busulfan resistance in a human glioblastoma multiforme xenograft.
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Characterization of three restricted specificity monoclonal antibodies raised against the human glioma cell line D-54 MG.
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Chemical sintering generates uniform porous hyaluronic acid hydrogels.
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Chemotherapy and radiation therapy of human medulloblastoma in athymic nude mice.
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Cholera toxin acts as a potent adjuvant for the induction of cytotoxic T-lymphocyte responses with non-replicating antigens.
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Choline attenuates inflammatory hyperalgesia activating nitric oxide/cGMP/ATP-sensitive potassium channels pathway.
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Chronic treatment in vivo with β-adrenoceptor agonists induces dysfunction of airway β(2) -adrenoceptors and exacerbates lung inflammation in mice.
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Circulating mitochondria in organ donors promote allograft rejection.
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Circumventing tamoxifen resistance in breast cancers using antiestrogens that induce unique conformational changes in the estrogen receptor.
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Cl- and K+ transport in human biliary cell lines.
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Cloning of B cells from autoimmune MRL-lpr/lpr and MRL.xid mice.
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Cloning of a complementary DNA encoding a new mouse B lymphocyte differentiation antigen, homologous to the human B1 (CD20) antigen, and localization of the gene to chromosome 19.
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Cloning of cDNA and analysis of the gene for mouse angiotensin II type 2 receptor.
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Cloning of mitogen- and antigen-reactive B lymphocytes on filter paper discs. II. Paratope frequencies within the mitogen-selected repertoire.
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Co-delivery of antigen and IL-12 by Venezuelan equine encephalitis virus replicon particles enhances antigen-specific immune responses and antitumor effects.
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Coadministration of IL-12 or IL-10 expression cassettes drives immune responses toward a Th1 phenotype.
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Codon usage optimization of HIV type 1 subtype C gag, pol, env, and nef genes: in vitro expression and immune responses in DNA-vaccinated mice.
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Combination testing (Stage 2) of the Anti-IGF-1 receptor antibody IMC-A12 with rapamycin by the pediatric preclinical testing program.
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Combination testing of cediranib (AZD2171) against childhood cancer models by the pediatric preclinical testing program.
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Combination treatment of murine tumors by adenovirus-mediated local B7/IL12 immunotherapy and radiotherapy.
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Combined inhibition of RNA polymerase I and mTORC1/2 synergize to combat oral squamous cell carcinoma.
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Combining PARP-1 inhibition and radiation in Ewing sarcoma results in lethal DNA damage.
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Comparative analysis of antigen loading strategies of dendritic cells for tumor immunotherapy.
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Comparative and functional evaluation of in vitro generated to ex vivo CD8 T cells.
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Comparative effects of thermosensitive doxorubicin-containing liposomes and hyperthermia in human and murine tumours.
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Comparative immunogenicity of HIV-1 gp160, gp140 and gp120 expressed by live attenuated newcastle disease virus vector.
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Comparative tissue distribution in mice of the alpha-emitter 211At and 131I as labels of a monoclonal antibody and F(ab')2 fragment.
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Comparison of [18 F]fluorocholine and [18 F]fluorodeoxyglucose for positron emission tomography of androgen dependent and androgen independent prostate cancer.
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Comparison of intradermal and intramuscular delivery followed by in vivo electroporation of SIV Env DNA in macaques.
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Comparison of the roles of calcineurin in physiology and virulence in serotype D and serotype A strains of Cryptococcus neoformans.
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Complex Antigens Drive Permissive Clonal Selection in Germinal Centers.
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Conjugate of Doxorubicin to Albumin-Binding Peptide Outperforms Aldoxorubicin.
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Contrasting response of lung parenchymal cells to instilled TNF alpha and IFN gamma: the inducibility of specific cell ICAM-1 in vivo.
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Corneal penetration of topical and subconjunctival bevacizumab.
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Corticorelin acetate, a synthetic corticotropin-releasing factor with preclinical antitumor activity, alone and with bevacizumab, against human brain tumor models.
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Covalent complexes of antigen and alpha(2)-macroglobulin: evidence for dramatically-increased immunogenicity.
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Creatine kinase activity as an indicator of unopposed estrogen action in the mouse uterus associated with anti-progesterone treatment.
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Creation of human tumour cells with defined genetic elements.
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Cross-reactive monoclonal antibodies to multiple HIV-1 subtype and SIVcpz envelope glycoproteins.
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Cross-subtype T-cell immune responses induced by a human immunodeficiency virus type 1 group m consensus env immunogen.
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Cryptococcus gattii VGIII isolates causing infections in HIV/AIDS patients in Southern California: identification of the local environmental source as arboreal.
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Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors.
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Cutting edge: TGF-beta-induced expression of Foxp3 in T cells is mediated through inactivation of ERK.
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Cyclic AMP-dependent protein kinase controls virulence of the fungal pathogen Cryptococcus neoformans.
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Cyclin D1 overexpression and response to bortezomib treatment in a breast cancer model.
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Cyclophosphamide treatment used to manipulate the immune response for the production of monoclonal antibodies.
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Cytokine deposition alters leukocyte morphology and initial recruitment of monocytes and γδT cells after corneal injury.
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Cytokine expression in vivo during murine herpetic stromal keratitis. Effect of protective antibody therapy.
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Cytokine requirements for induction of systemic and mucosal CTL after nasal immunization.
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Cytokines as adjuvants for the induction of anti-human immunodeficiency virus peptide immunoglobulin G (IgG) and IgA antibodies in serum and mucosal secretions after nasal immunization.
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Cytosolic TMEM88 promotes invasion and metastasis in lung cancer cells by binding DVLS.
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Cytotoxic-T-lymphocyte-mediated elimination of target cells transduced with engineered adeno-associated virus type 2 vector in vivo.
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D614G Spike Mutation Increases SARS CoV-2 Susceptibility to Neutralization.
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DMT1 expression is increased in the lungs of hypotransferrinemic mice.
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DNA transfection of macaque and murine respiratory tissue is greatly enhanced by use of a nuclease inhibitor.
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DNA vaccination by intradermal electroporation induces long-lasting immune responses in rhesus macaques.
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DNA vaccine molecular adjuvants SP-D-BAFF and SP-D-APRIL enhance anti-gp120 immune response and increase HIV-1 neutralizing antibody titers.
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Decreased cochlear DNA receptor staining in MRL.MpJ-Fas(lpr) autoimmune mice with hearing loss.
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Defects in intracellular trafficking of fungal cell wall synthases lead to aberrant host immune recognition.
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Deficiency of 5-lipoxygenase accelerates renal allograft rejection in mice.
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Definition of a novel cellular constituent of the bone marrow that regulates the response of immature B cells to B cell antigen receptor engagement.
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Depleting regulatory T cells with arginine-rich, cell-penetrating, peptide-conjugated morpholino oligomer targeting FOXP3 inhibits regulatory T-cell function.
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Depletion of passenger leukocytes from corneal grafts: an effective means of promoting transplant survival?
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Description of monoclonal antibody defining an HLA allotypic determinant that includes specificities within the B5 cross-reacting group.
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Design and characterization of a peptide mimotope of the HIV-1 gp120 bridging sheet.
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Design and characterization of microporous hyaluronic acid hydrogels for in vitro gene transfer to mMSCs.
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Detection of Ebola virus envelope using monoclonal and polyclonal antibodies in ELISA, surface plasmon resonance and a quartz crystal microbalance immunosensor.
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Detection of mouse cytomegalovirus nucleic acid in latently infected mice by in vitro enzymatic amplification.
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Detection of murine cytomegalovirus immediate early 1 transcripts in the spleens of latently infected mice.
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Detection of near-atmospheric concentrations of CO2 by an olfactory subsystem in the mouse.
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Determinants of the source of cytomegalovirus in murine renal allograft recipients.
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Determination of the functional status of alloreactive T cells by interferon-gamma kinetics.
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Development and characterization of a monoclonal antibody to human embryonal carcinoma.
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Development and distribution of a human B cell subpopulation identified by the HB-4 monoclonal antibody.
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Development and preclinical evaluation of an alphavirus replicon particle vaccine for cytomegalovirus.
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Development and use of SIV-based Integrase defective lentiviral vector for immunization.
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Development of a model of melphalan-induced gastrointestinal toxicity in mice.
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Development of a monoclonal antibody specific for serotype 3 rotavirus strains.
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Developmental regulation of lymphocyte-specific protein 1 (LSP1) expression in thymus during human T-cell maturation.
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Differential anti-inflammatory effects of LPS in susceptible and resistant mouse strains.
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Differential expression of p63 isoforms in female reproductive organs.
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Differential osteopontin expression in phenotypically distinct subclones of murine breast cancer cells mediates metastatic behavior.
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Differential pulmonary transcriptomic profiles in murine lungs infected with low and highly virulent influenza H3N2 viruses reveal dysregulation of TREM1 signaling, cytokines, and chemokines.
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Differential seizure sensitivities to picrotoxinin in two inbred strains of mice (DBA/2J and BALB/c ByJ): parallel changes in GABA receptor-mediated chloride flux and receptor binding.
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Differentiation of human T lymphocytes. I. Acquisition of a novel human cell surface protein (p80) during normal intrathymic T cell maturation.
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Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton's Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers.
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Disialoganglioside GD2 in human neuroectodermal tumor cell lines and gliomas.
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Disparity in the kinetics of onset of hypermutation in immunoglobulin heavy and light chains.
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Dissecting the roles of E1A and E1B in adenoviral replication and RCAd-enhanced RDAd transduction efficacy on tumor cells.
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Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells.
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Distinct granuloma responses in C57BL/6J and BALB/cByJ mice in response to pristane.
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Distinct routes to metastasis: plasticity-dependent and plasticity-independent pathways.
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Donor-derived regulatory B cells are important for suppression of murine sclerodermatous chronic graft-versus-host disease.
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Donor-derived, tolerogenic dendritic cells suppress immune rejection in the indirect allosensitization-dominant setting of corneal transplantation.
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Donor-specific CD8+ Foxp3+ T cells protect skin allografts and facilitate induction of conventional CD4+ Foxp3+ regulatory T cells.
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Downregulation of T cell receptor expression by CD8(+) lymphocytes in kidney allografts.
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Doxorubicin-conjugated polypeptide nanoparticles inhibit metastasis in two murine models of carcinoma.
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Drug-Resistant Epimutants Exhibit Organ-Specific Stability and Induction during Murine Infections Caused by the Human Fungal Pathogen Mucor circinelloides.
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Dynamically Timed Stimulation of Corticolimbic Circuitry Activates a Stress-Compensatory Pathway.
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EAG2 potassium channel with evolutionarily conserved function as a brain tumor target.
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ECDI-fixed allogeneic splenocytes induce donor-specific tolerance for long-term survival of islet transplants via two distinct mechanisms.
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EGF promotes mammalian cell growth by suppressing cellular senescence.
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ELR+ CXC chemokines and oncogenic Ras-mediated tumorigenesis.
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Echocardiographically detected myocardial infarction in the mouse.
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Effect of CXCL-1/KC production in high risk vascularized corneal allografts on T cell recruitment and graft rejection.
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Effect of HIV-1 envelope cytoplasmic tail on adenovirus primed virus encoded virus-like particle immunizations.
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Effect of cocaine and cocaine congeners on veratridine-induced depolarization in mouse cerebrocortical synaptoneurosomes.
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Effect of cytofectins on the immune response of murine macrophages to mammalian DNA.
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Effect of immunosuppressants on T-cell subsets observed in vivo using carboxy-fluorescein diacetate succinimidyl ester labeling.
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Effect of interleukin-1β on the expression of actin isoforms in cultured mouse astroglia.
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Effect of intraocular gamma-interferon on immunoregulatory properties of iris and ciliary body cells.
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Effect of preexposure to ultrafine carbon black on respiratory syncytial virus infection in mice.
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Effect of sex on the induction of anti-DNA antibodies in normal mice immunized with bacterial DNA.
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Effect of the laccase gene CNLAC1, on virulence of Cryptococcus neoformans.
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Effect of the nitric oxide donor V-PYRRO/NO on portal pressure and sinusoidal dynamics in normal and cirrhotic mice.
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Effect of topical azithromycin on corneal innate immune responses.
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Effect of vasoactive intestinal peptide (VIP) on cytokine production and expression of VIP receptors in thymocyte subsets.
-
Effective antibody therapy in herpes simplex virus ocular infection. Characterization of recipient immune response.
-
Effective induction of protective systemic immunity with nasally administered vaccines adjuvanted with IL-1.
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Effects of IL-1 on hematopoietic progenitors after myelosuppressive chemoradiotherapy.
-
Effects of acute tryptophan depletion on brain serotonin function and concentrations of dopamine and norepinephrine in C57BL/6J and BALB/cJ mice.
-
Effects of rate, volume, and dose of intratumoral infusion on virus dissemination in local gene delivery.
-
Effects of the proteasome inhibitor PS-341 on apoptosis and angiogenesis in orthotopic human pancreatic tumor xenografts.
-
Effects of therapy on the 1H NMR spectrum of a human glioma line.
-
Effects of topical and subconjunctival bevacizumab in high-risk corneal transplant survival.
-
Efficacy of multiple administrations of a recombinant adenovirus expressing wild-type p53 in an immune-competent mouse tumor model.
-
Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow.
-
Electric fields in tumors exposed to external voltage sources: implication for electric field-mediated drug and gene delivery.
-
Electromobility of plasmid DNA in tumor tissues during electric field-mediated gene delivery.
-
Elevated DNA polymerase alpha, DNA polymerase beta, and DNA topoisomerase II in a melphalan-resistant rhabdomyosarcoma xenograft that is cross-resistant to nitrosoureas and topotecan.
-
Elimination of mycoplasma from human B-lymphoblastoid cell lines.
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Endothelial Cell-Derived Extracellular Vesicles Mitigate Radiation-Induced Hematopoietic Injury.
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Endothelial progenitor cell infusion induces hematopoietic stem cell reconstitution in vivo.
-
Engineering DNA vaccines via co-delivery of co-stimulatory molecule genes.
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Engineering and Selection of Shuffled AAV Genomes: A New Strategy for Producing Targeted Biological Nanoparticles.
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Engraftment of a galactose receptor footprint onto adeno-associated viral capsids improves transduction efficiency.
-
Enhanced activation of human dendritic cells by inducible CD40 and Toll-like receptor-4 ligation.
-
Enhanced allergen-induced airway inflammation in paucity of lymph node T cell (plt) mutant mice.
-
Enhanced avidity maturation of antibody to human immunodeficiency virus envelope: DNA vaccination with gp120-C3d fusion proteins.
-
Enhanced green fluorescent protein as a marker for localizing murine cytomegalovirus in acute and latent infection.
-
Enhanced melphalan cytotoxicity following buthionine sulfoximine-mediated glutathione depletion in a human medulloblastoma xenograft in athymic mice.
-
Enhanced priming of adaptive immunity by a proapoptotic mutant of Mycobacterium tuberculosis.
-
Enhanced transduction and improved photoreceptor survival of retinal degeneration by the combinatorial use of rAAV2 with a lower dose of adenovirus.
-
Enhanced tumour uptake of radiolabelled antibodies by hyperthermia. Part II: Application of the thermal equivalency equation.
-
Enhanced tumour uptake of radiolabelled antibodies by hyperthermia: Part I: Timing of injection relative to hyperthermia.
-
Enhancement of antibodies to the human immunodeficiency virus type 1 envelope by using the molecular adjuvant C3d.
-
Enhancement of cancer radiation therapy by use of adenovirus-mediated secretable glucose-regulated protein 94/gp96 expression.
-
Enhancement of electric field-mediated gene delivery through pretreatment of tumors with a hyperosmotic mannitol solution.
-
Enhancement of irinotecan (CPT-11) activity against central nervous system tumor xenografts by alkylating agents.
-
Enhancement of melphalan activity by inhibition of DNA polymerase-alpha and DNA polymerase-beta.
-
Enhancement of melphalan-induced gastrointestinal toxicity in mice treated with regional hyperthermia and BSO-mediated glutathione depletion.
-
Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme.
-
Enhancement of rAAV2-mediated transgene expression in retina cells in vitro and in vivo by coadministration of low-dose chemotherapeutic drugs.
-
Enzyme-Responsive Delivery of Multiple Proteins with Spatiotemporal Control.
-
Epigenetic instability of cytokine and transcription factor gene loci underlies plasticity of the T helper 17 cell lineage.
-
Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells.
-
Epitope insertion into variable loops of HIV-1 gp120 as a potential means to improve immunogenicity of viral envelope protein.
-
Epitope maps of the Escherichia coli heat-labile toxin B subunit for development of a synthetic oral vaccine.
-
Erythropoietin blockade inhibits the induction of tumor angiogenesis and progression.
-
Establishing an accurate gas phase reference frequency to quantify 129 Xe chemical shifts in vivo.
-
Establishment of a melphalan-resistant rhabdomyosarcoma xenograft with cross-resistance to vincristine and enhanced sensitivity following buthionine sulfoximine-mediated glutathione depletion.
-
Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation.
-
Ethylenecarbodiimide-fixed donor splenocyte infusions differentially target direct and indirect pathways of allorecognition for induction of transplant tolerance.
-
Evaluation of an internalizing monoclonal antibody labeled using N-succinimidyl 3-[131I]iodo-4-phosphonomethylbenzoate ([131I]SIPMB), a negatively charged substituent bearing acylation agent.
-
Evaluation of anti-podoplanin rat monoclonal antibody NZ-1 for targeting malignant gliomas.
-
Evaluation of meta-[211At]astatobenzylguanidine in an athymic mouse human neuroblastoma xenograft model.
-
Evaluation of recombinant adenovirus vaccines based on glycoprotein D and truncated UL25 against herpes simplex virus type 2 in mice.
-
Evaluation of tumor microenvironment in an animal model using a nanoparticle contrast agent in computed tomography imaging.
-
Evidence that there is no direct correlation between alpha 2-adrenoceptor antagonism and inhibition of voltage-dependent sodium channels.
-
Experimental chemotherapy of human medulloblastoma cell lines and transplantable xenografts with bifunctional alkylating agents.
-
Experimental chemotherapy of human medulloblastoma with classical alkylators.
-
Experimental study of the effect of diethylstilbestrol on the development of the human female reproductive tract.
-
Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies.
-
Exposure to particulate hexavalent chromium exacerbates allergic asthma pathology.
-
Expression of C3d receptors during human B cell differentiation: immunofluorescence analysis with the HB-5 monoclonal antibody.
-
Expression of a highly conserved anti-DNA idiotype in normal and autoimmune mice.
-
Expression of a murine cytomegalovirus early-late protein in "latently" infected mice.
-
Expression of an antisense transforming growth factor-beta1 transgene reduces tumorigenicity of EMT6 mammary tumor cells.
-
Expression of extracellular glutathione peroxidase in human and mouse gastrointestinal tract.
-
Expression of heme oxygenase-1 can determine cardiac xenograft survival.
-
FGF2 suppresses neuronogenesis of a cell line derived from rat olfactory epithelium.
-
Factors influencing phenotypic diversity of human prostate carcinoma cells metastasizing in athymic nude mice.
-
Facultative role of germinal centers and T cells in the somatic diversification of IgVH genes.
-
Fibulin-3 is a novel TGF-β pathway inhibitor in the breast cancer microenvironment.
-
Flunarizine enhancement of melphalan activity against drug-sensitive/resistant rhabdomyosarcoma.
-
Fluorescence-based isolation of bacterial genes expressed within host cells.
-
Fluorine-18 labeled chemotactic peptides: a potential approach for the PET imaging of bacterial infection.
-
Fluorine-18 labeling of monoclonal antibodies and fragments with preservation of immunoreactivity.
-
Fluorine-18-labeled [Nle4,D-Phe7]-alpha-MSH, an alpha-melanocyte stimulating hormone analogue.
-
FoxO-dependent regulation of diacylglycerol kinase α gene expression.
-
Function of nuclear factor kappaB in pancreatic cancer metastasis.
-
Functional analysis of the putative integrin recognition motif on adeno-associated virus 9.
-
Functional characteristics and survival requirements of memory CD4+ T lymphocytes in vivo.
-
Functional, non-clonal IgMa-restricted B cell receptor interactions with the HIV-1 envelope gp41 membrane proximal external region.
-
Fusion of the termini of the murine cytomegalovirus genome after infection.
-
GD3 expression by cultured human tumor cells of neuroectodermal origin.
-
GFRα1 released by nerves enhances cancer cell perineural invasion through GDNF-RET signaling.
-
GRP94 (gp96) and GRP94 N-terminal geldanamycin binding domain elicit tissue nonrestricted tumor suppression.
-
Gain of glucose-independent growth upon metastasis of breast cancer cells to the brain.
-
Galphaz negatively regulates insulin secretion and glucose clearance.
-
Gamma-irradiation reduces the allogenicity of donor corneas.
-
Gastroesophageal reflux-associated aspiration alters the immune response in asthma.
-
Gender differences in human immunodeficiency virus type 1-specific CD8 responses in the reproductive tract and colon following nasal peptide priming and modified vaccinia virus Ankara boosting.
-
Gene duplications at the chemokine locus on mouse chromosome 4: multiple strain-specific haplotypes and the deletion of secondary lymphoid-organ chemokine and EBI-1 ligand chemokine genes in the plt mutation.
-
Gene expression signatures of radiation response are specific, durable and accurate in mice and humans.
-
Gene expression-based classifiers identify Staphylococcus aureus infection in mice and humans.
-
Generation of CD8+ T-cell responses by a recombinant nonpathogenic Mycobacterium smegmatis vaccine vector expressing human immunodeficiency virus type 1 Env.
-
Generation of a polyclonal Fab phage display library to the protozoan parasite Cryptosporidium parvum.
-
Generation of a polyclonal fab phage display library to the human breast carcinoma cell line BT-20.
-
Generation of mucosal anti-human immunodeficiency virus type 1 T-cell responses by recombinant Mycobacterium smegmatis.
-
Genetic analysis of intracranial tumors in a murine model of glioma demonstrate a shift in gene expression in response to host immunity.
-
Genetic control of the immune response to staphylococcal nuclease. IX. Recombination between genes determining BALB/c antinuclease idiotypes and the heavy chain allotype locus.
-
Genetic elimination of α3(IV) collagen fails to rescue anti-collagen B cells.
-
Genetic immunization with LYVE-1 cDNA yields function-blocking antibodies against native protein.
-
Genetic modification of mesenchymal stem cells overexpressing CCR1 increases cell viability, migration, engraftment, and capillary density in the injured myocardium.
-
Genotypic analysis of B cell colonies by in situ hybridization. Stoichiometric expression of three VH families in adult C57BL/6 and BALB/c mice.
-
Germinal center B cell depletion diminishes CD4+ follicular T helper cells in autoimmune mice.
-
Germline sequences of V(H)7183 gene family members in C57BL/6 mice demonstrate natural selection of particular sequences during recent evolution.
-
Glioblastoma stem cells generate vascular pericytes to support vessel function and tumor growth.
-
Glucagon-like peptide 2 for intestinal stem cell and Paneth cell repair during graft-versus-host disease in mice and humans.
-
Glucose-regulated protein 94/glycoprotein 96 elicits bystander activation of CD4+ T cell Th1 cytokine production in vivo.
-
Glutathione and glutathione S-transferase in benign and malignant prostate cell lines and prostate tissues.
-
Glycan binding avidity determines the systemic fate of adeno-associated virus type 9.
-
Graft-versus-host disease prevention by rapamycin: cellular mechanisms.
-
Growth factor receptor-bound protein 14 undergoes light-dependent intracellular translocation in rod photoreceptors: functional role in retinal insulin receptor activation.
-
Growth hormone accelerates immune recovery following allogeneic T-cell-depleted bone marrow transplantation in mice.
-
Growth hormone mitigates against lethal irradiation and enhances hematologic and immune recovery in mice and nonhuman primates.
-
Growth, morphology, and serial transplantation of anaplastic human gliomas in athymic mice.
-
Gαz regulates BDNF-induction of axon growth in cortical neurons.
-
H2-DMalpha(-/-) mice show the importance of major histocompatibility complex-bound peptide in cardiac allograft rejection.
-
HER2 overexpression elicits a proinflammatory IL-6 autocrine signaling loop that is critical for tumorigenesis.
-
HIV type 1 V3 region primer-induced antibody suppression is overcome by administration of C4-V3 peptides as a polyvalent immunogen.
-
HIV-1 Consensus Envelope-Induced Broadly Binding Antibodies.
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HIV-1 neutralizing monoclonal antibodies induced by a synthetic peptide.
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Had1 Is Required for Cell Wall Integrity and Fungal Virulence in Cryptococcus neoformans.
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Hemagglutinin stalk-based universal vaccine constructs protect against group 2 influenza A viruses.
-
Hematopoietic stem cell dose correlates with the speed of immune reconstitution after stem cell transplantation.
-
Heparan sulfate, an endogenous TLR4 agonist, promotes acute GVHD after allogeneic stem cell transplantation.
-
Hepatic stellate cells undermine the allostimulatory function of liver myeloid dendritic cells via STAT3-dependent induction of IDO.
-
Herpes simplex retinitis in the mouse. Clinicopathologic correlations.
-
Heterologous immunity triggered by a single, latent virus in Mus musculus: combined costimulation- and adhesion- blockade decrease rejection.
-
Hexa-acylated lipid A is required for host inflammatory response to Neisseria gonorrhoeae in experimental gonorrhea.
-
High intensity focused ultrasound-induced gene activation in solid tumors.
-
High-affinity, protective antibodies to the binding domain of botulinum neurotoxin type A.
-
High-frequency alloreactive T cells augment effector function of low-frequency CD8+ T-cell responses under CD28/CD154 blockade.
-
Histogenesis of dieldrin and DDT-induced hepatocellular carcinoma in Balb/c mice.
-
Histone deacetylase 11 inhibition promotes breast cancer metastasis from lymph nodes.
-
Histopathologic characteristics of two forms of experimental herpes simplex virus retinitis.
-
Host regulation of MOPC 104E plasmacytoma after reduction of tumor burden by total body irradiation.
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Human erythrocyte antigens: II. The In(Lu) gene regulates expression of an antigen on an 80-kilodalton protein of human erythrocytes.
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Human glioma-mesenchymal extracellular matrix antigen defined by monoclonal antibody.
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Human melanoma growth in the peritoneal cavity of the athymic mouse--a model for in vivo study of cell-mediated immunity.
-
Human thymic epithelial cells produce granulocyte and macrophage colony-stimulating factors.
-
Humoral antibody response and tumor transplantation resistance elicited by fetal tissues in mice.
-
Humoral autoimmunity to basement membrane antigens is regulated in C57BL/6 and MRL/MpJ mice transgenic for anti-laminin Ig receptors.
-
Hyperbaric oxygen and cyclosporine as a combined treatment regimen to prevent skin allograft rejection in immunohistoincompatible mice.
-
Hyperexpansion of Functional Viral-Specific CD8+ T Cells in Lymphopenia-Associated MCMV Pneumonitis.
-
Hyperpolarized 3He MRI in Asthma
-
Hyperthermia-induced enhancement of melphalan activity against a melphalan-resistant human rhabdomyosarcoma xenograft.
-
Hypoxia in the thymus: role of oxygen tension in thymocyte survival.
-
Hypoxia-independent activation of HIF-1 by enterobacteriaceae and their siderophores.
-
Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells.
-
IFN-gamma dictates allograft fate via opposing effects on the graft and on recipient CD8 T cell responses.
-
IL-1 is an effective adjuvant for mucosal and systemic immune responses when coadministered with protein immunogens.
-
IL-10 induces regulatory T cell apoptosis by up-regulation of the membrane form of TNF-alpha.
-
IL-13 and IL-1beta promote lung fibroblast growth through coordinated up-regulation of PDGF-AA and PDGF-Ralpha.
-
IL-4-STAT6 signal transduction-dependent induction of the clinical phase of Sjögren's syndrome-like disease of the nonobese diabetic mouse.
-
Ibudilast sensitizes glioblastoma to temozolomide by targeting Macrophage Migration Inhibitory Factor (MIF).
-
Identification and characterization of the Cryptococcus neoformans phosphomannose isomerase-encoding gene, MAN1, and its impact on pathogenicity.
-
Identification of alpha-melanocyte stimulating hormone as a potential immunosuppressive factor in aqueous humor.
-
Identification of five hemoglobins in B6C3F1 mice by mass spectrometry and sequence analysis.
-
Identification of genes contributing to the obese yellow Avy phenotype: caloric restriction, genotype, diet x genotype interactions.
-
Identification of host-induced pathogen genes by differential fluorescence induction reporter systems.
-
Identification of liver cancer-specific aptamers using whole live cells.
-
Identification of the MATa mating-type locus of Cryptococcus neoformans reveals a serotype A MATa strain thought to have been extinct.
-
Idiotypic analysis of a monoclonal anti-Sm antibody. II. Strain distribution of a common idiotypic determinant and its relationship to anti-Sm expression.
-
Idiotypic cross-reaction between MRL autoantibodies and a BALB/c myeloma.
-
Idiotypic cross-reaction between MRL monoclonal autoantibodies with different antigen specificity.
-
Idiotypic determinants used in the analysis of antibody diversification and as regulatory targets.
-
Imidazo[4,5-d]thiazolo[5,4-b]pyridine based inhibitors of IKK2: synthesis, SAR, PK/PD and activity in a preclinical model of rheumatoid arthritis.
-
Immune cells in a mouse airway model of obliterative bronchiolitis.
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Immunization with the Haemophilus ducreyi trimeric autotransporter adhesin DsrA with alum, CpG or imiquimod generates a persistent humoral immune response that recognizes the bacterial surface.
-
Immunoaffinity purification of human O6-alkylguanine-DNA alkyltransferase using newly developed monoclonal antibodies.
-
Immunogenicity of membrane-bound HIV-1 gp41 membrane-proximal external region (MPER) segments is dominated by residue accessibility and modulated by stereochemistry.
-
Immunohistochemical analysis of the pathogenesis of posterior polymorphous dystrophy.
-
Immunologic control of the ascites form of murine adenocarcinoma 755. III. Efficacy of serum therapy is controlled by a single genetic locus.
-
Immunologic control of the ascites form of murine adenocarcinoma 755. V. Antibody-directed macrophages mediate tumor cell destruction.
-
Immunological disruption of antiangiogenic signals by recruited allospecific T cells leads to corneal allograft rejection.
-
Immunomodulator effect of picroliv and its potential in treatment against resistant Plasmodium yoelii (MDR) infection in mice.
-
Immunomodulatory Effects of Fentanyl or Dexmedetomidine Hydrochloride Infusion After Allogeneic Heart Transplantation in Mice.
-
Immunosuppressive and nonimmunosuppressive cyclosporine analogs are toxic to the opportunistic fungal pathogen Cryptococcus neoformans via cyclophilin-dependent inhibition of calcineurin.
-
Immunotherapeutic potential of tumor antigen-pulsed and unpulsed dendritic cells generated from murine bone marrow.
-
Immunotherapy using allogeneic squamous cell tumor-dendritic cell fusion hybrids.
-
Immunotherapy with vaccines combining MHC class II/CD80+ tumor cells with interleukin-12 reduces established metastatic disease and stimulates immune effectors and monokine induced by interferon gamma.
-
Impact of Heparan Sulfate Binding on Transduction of Retina by Recombinant Adeno-Associated Virus Vectors.
-
Impact of Leukocyte Function-Associated Antigen-1 Blockade on Endogenous Allospecific T Cells to Multiple Minor Histocompatibility Antigen Mismatched Cardiac Allograft.
-
Impaired limbic gamma oscillatory synchrony during anxiety-related behavior in a genetic mouse model of bipolar mania.
-
Impairing oral tolerance promotes allergy and anaphylaxis: a new murine food allergy model.
-
Improved antitumor activity of a recombinant anti-Lewis(y) immunotoxin not requiring proteolytic activation.
-
Improved xenograft targeting of tumor-specific anti-epidermal growth factor receptor variant III antibody labeled using N-succinimidyl 4-guanidinomethyl-3-iodobenzoate.
-
In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations.
-
In vitro and in vivo activity of murine lymphokine-activated killer cells after cryopreservation.
-
In vitro and in vivo characterization of anthrax anti-protective antigen and anti-lethal factor monoclonal antibodies after passive transfer in a mouse lethal toxin challenge model to define correlates of immunity.
-
In vitro and in vivo expression of a nephritogenic Ig heavy chain determinant: pathogenic autoreactivity requires permissive light chains.
-
In vitro and in vivo inhibitory activities of rutin, wogonin, and quercetin on lipopolysaccharide-induced nitric oxide and prostaglandin E(2) production.
-
In vitro and in vivo osteoblastic differentiation of BMP-2- and Runx2-engineered skeletal myoblasts.
-
In vitro inhibition of murine IFN gamma production by phosphorothioate deoxyguanosine oligomers.
-
In vivo assessment of LV mass in mice using high-frequency cardiac ultrasound: necropsy validation.
-
In vivo bioluminescence imaging monitoring of hypoxia-inducible factor 1alpha, a promoter that protects cells, in response to chemotherapy.
-
In vivo bioluminescent imaging of influenza a virus infection and characterization of novel cross-protective monoclonal antibodies.
-
In vivo cytotoxic T lymphocyte induction with soluble proteins administered in liposomes.
-
In vivo delivery of synthetic DNA-encoded antibodies induces broad HIV-1-neutralizing activity.
-
In vivo downregulation of innate and adaptive immune responses in corneal allograft rejection by HC-HA/PTX3 complex purified from amniotic membrane.
-
In vivo electroporation and non-protein based screening assays to identify antibodies against native protein conformations.
-
In vivo evaluation of cell mediated immunity against human melanoma.
-
In vivo expansion, persistence, and function of peptide vaccine-induced CD8 T cells occur independently of CD4 T cells.
-
In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment.
-
In vivo luminescent imaging of NF-κB activity and NF-κB-related serum cytokine levels predict pain sensitivities in a rodent model of peripheral neuropathy.
-
In vivo noninvasive detection of Brown Adipose Tissue through intermolecular zero-quantum MRI.
-
In vivo reprogramming of hTERT by trans-splicing ribozyme to target tumor cells.
-
In-vivo impaired T helper 1 cell development in submandibular lymph nodes due to IL-12 deficiency following antigen injection into the anterior chamber of the eye.
-
Inability of memory T cells to induce graft-versus-host disease is a result of an abortive alloresponse.
-
Increased binding affinity enhances targeting of glioma xenografts by EGFRvIII-specific scFv.
-
Increased immunogenicity of HIV envelope subunit complexed with alpha2-macroglobulin when combined with monophosphoryl lipid A and GM-CSF.
-
Increased immunogenicity of a DNA-launched Venezuelan equine encephalitis virus-based replicon DNA vaccine.
-
Increasing vaccine potency through exosome antigen targeting.
-
Inducible regulation of Runx2-stimulated osteogenesis.
-
Induction in vitro of primary cytotoxic T-lymphocyte responses with DNA encoding herpes simplex virus proteins.
-
Induction of anti-double stranded DNA antibodies in normal mice by immunization with bacterial DNA.
-
Induction of immune activation by a novel immunomodulatory oligonucleotide without thymocyte apoptosis.
-
Induction of neutralizing antibodies and cytotoxic T lymphocytes in Balb/c mice immunized with virus-like particles presenting a gp120 molecule from a HIV-1 isolate of clade A.
-
Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement.
-
Induction of potent humoral and cell-mediated immune responses following direct injection of DNA encoding the HIV type 1 env and rev gene products.
-
Infection with Francisella tularensis LVS clpB leads to an altered yet protective immune response.
-
Influence of amino acids encoded in the 3' open reading frame of the SV40 early region on transformation and antigenicity of large T antigen.
-
Influence of backbone chemistry on immune activation by synthetic oligonucleotides.
-
Influence of mouse hepatitis virus on the growth of human melanoma in the peritoneal cavity of the athymic mouse.
-
Influenza Antigen Engineering Focuses Immune Responses to a Subdominant but Broadly Protective Viral Epitope.
-
Inhibition of T cell costimulation by VCAM-1 prevents murine graft-versus-host disease across minor histocompatibility barriers.
-
Inhibition of haematogenous metastasis of colon cancer in mice by a selective COX-2 inhibitor, JTE-522.
-
Inhibition of human corneal epithelium with immunotoxin 454A12-rRA.
-
Inhibition of in vitro NZB antibody responses by cyclosporine.
-
Inhibition of in vivo tumor angiogenesis and growth via systemic delivery of an angiopoietin 2-specific RNA aptamer.
-
Inhibition of lymphocyte proliferation by a synthetic peptide homologous to retroviral envelope proteins.
-
Inhibition of murine dendritic cell activation by synthetic phosphorothioate oligodeoxynucleotides.
-
Inhibition of murine macrophage IL-12 production by natural and synthetic DNA.
-
Inhibition of nitric oxide synthesis increases mortality in Sindbis virus encephalitis.
-
Inhibition of spinal p38 MAPK prevents articular neutrophil infiltration in experimental arthritis via sympathetic activation.
-
Inhibition of telomerase is related to the life span and tumorigenicity of human prostate cancer cells.
-
Inhibition of the growth of human melanoma metastases in nude mice by melanoma-specific murine monoclonal antibody.
-
Inhibition of the growth of human melanoma xenografts in nude mice by human tumor-specific cytotoxic T-cells.
-
Inhibition of the vacuolar H(+)-pump with bafilomycin A1 does not induce acrosome reaction or activate proacrosin in mouse spermatozoa.
-
Initial Testing (Stage 1) of MK-8242-A Novel MDM2 Inhibitor-by the Pediatric Preclinical Testing Program.
-
Initial stages of tumor cell-induced angiogenesis: evaluation via skin window chambers in rodent models.
-
Initial testing (Stage 1) of AT13387, an HSP90 inhibitor, by the pediatric preclinical testing program.
-
Initial testing (stage 1) by the pediatric preclinical testing program of RO4929097, a γ-secretase inhibitor targeting notch signaling.
-
Initial testing (stage 1) of AZD6244 (ARRY-142886) by the Pediatric Preclinical Testing Program.
-
Initial testing (stage 1) of eribulin, a novel tubulin binding agent, by the pediatric preclinical testing program.
-
Initial testing (stage 1) of mapatumumab (HGS-ETR1) by the pediatric preclinical testing program.
-
Initial testing (stage 1) of temozolomide by the pediatric preclinical testing program.
-
Initial testing (stage 1) of the Akt inhibitor GSK690693 by the pediatric preclinical testing program.
-
Initial testing (stage 1) of the IGF-1 receptor inhibitor BMS-754807 by the pediatric preclinical testing program.
-
Initial testing (stage 1) of the curaxin CBL0137 by the pediatric preclinical testing program.
-
Initial testing (stage 1) of the histone deacetylase inhibitor, quisinostat (JNJ-26481585), by the Pediatric Preclinical Testing Program.
-
Initial testing (stage 1) of the kinesin spindle protein inhibitor ispinesib by the pediatric preclinical testing program.
-
Initial testing (stage 1) of the mTOR kinase inhibitor AZD8055 by the pediatric preclinical testing program.
-
Initial testing (stage 1) of the multi-targeted kinase inhibitor sorafenib by the pediatric preclinical testing program.
-
Initial testing (stage 1) of the notch inhibitor PF-03084014, by the pediatric preclinical testing program.
-
Initial testing (stage 1) of the phosphatidylinositol 3' kinase inhibitor, SAR245408 (XL147) by the pediatric preclinical testing program.
-
Initial testing (stage 1) of the polyamine analog PG11047 by the pediatric preclinical testing program.
-
Initial testing (stage 1) of vorinostat (SAHA) by the pediatric preclinical testing program.
-
Initial testing of JNJ-26854165 (Serdemetan) by the pediatric preclinical testing program.
-
Initial testing of VS-4718, a novel inhibitor of focal adhesion kinase (FAK), against pediatric tumor models by the Pediatric Preclinical Testing Program.
-
Initial testing of aplidin by the pediatric pre-clinical testing program.
-
Initial testing of cisplatin by the pediatric preclinical testing program.
-
Initial testing of the VEGFR inhibitor AZD2171 by the pediatric preclinical testing program.
-
Initial testing of the aurora kinase A inhibitor MLN8237 by the Pediatric Preclinical Testing Program (PPTP).
-
Initial testing of the investigational NEDD8-activating enzyme inhibitor MLN4924 by the pediatric preclinical testing program.
-
Injectable polypeptide micelles that form radiation crosslinked hydrogels in situ for intratumoral radiotherapy.
-
Insulin-like growth factor 1 mitigates hematopoietic toxicity after lethal total body irradiation.
-
Integrin alpha 6 regulates glioblastoma stem cells.
-
Interaction of Clostridium difficile and Escherichia coli with microfloras in continuous-flow cultures and gnotobiotic mice.
-
Interaction of TLR2 and TLR4 ligands with the N-terminal domain of Gp96 amplifies innate and adaptive immune responses.
-
Interactions between precipitating and nonprecipitating antibodies in the formation of immune complexes.
-
Interferon gamma (IFNgamma) gene transfer of an EMT6 tumor that is poorly responsive to IFNgamma stimulation: increase in tumor immunogenicity is accompanied by induction of a mouse class II transactivator and class II MHC.
-
Interleukin 21 (IL-21) regulates chronic allograft vasculopathy (CAV) in murine heart allograft rejection.
-
Interleukin-2 immunotherapy of murine cytomegalovirus retinitis during MAIDS correlates with increased intraocular CD8+ T-cell infiltration.
-
Intracellular adhesion molecule-1 modulates beta-chemokines and directly costimulates T cells in vivo.
-
Intracerebral cytokine mRNA expression during fatal and nonfatal alphavirus encephalitis suggests a predominant type 2 T cell response.
-
Intracerebral growth of a human glioma tumor line in athymic mice and treatment with procarbazine, 1,3-bis(2-chloroethyl)-1-nitrosourea, aziridinylbenzoquinone, and cis-platinum.
-
Intragraft CD11b(+) IDO(+) cells mediate cardiac allograft tolerance by ECDI-fixed donor splenocyte infusions.
-
Intranasal immunization with CTL epitope peptides from HIV-1 or ovalbumin and the mucosal adjuvant cholera toxin induces peptide-specific CTLs and protection against tumor development in vivo.
-
Intranasal vaccination with the recombinant Listeria monocytogenes ΔactA prfA* mutant elicits robust systemic and pulmonary cellular responses and secretory mucosal IgA.
-
Intraportal injection of monoclonal antibody in nude mice bearing hepatic metastases.
-
Involvement of R-cadherin in the early stage of glomerulogenesis.
-
Involvement of an ATP-dependent peptide chaperone in cross-presentation after DNA immunization.
-
Involvement of dynamin-2 in formation of discoid vesicles in urinary bladder umbrella cells.
-
Iodopyridine-for-iodobenzene substitution for use with low molecular weight radiopharmaceuticals: application to m-iodobenzylguanidine.
-
Ipr gene control of the anti-DNA antibody response.
-
Iron negative foci and nodules in safrole-exposed mouse liver made siderotic by iron-dextran injection.
-
Isolation of a functional human gene for brain creatine kinase.
-
Isolation of cDNAs encoding the CD19 antigen of human and mouse B lymphocytes. A new member of the immunoglobulin superfamily.
-
Kappa editing rescues autoreactive B cells destined for deletion in mice transgenic for a dual specific anti-laminin Ig.
-
L-amino acid oxidase (LOX) modulation of melphalan activity against intracranial glioma.
-
L-buthionine-sulfoximine-mediated radiosensitization in experimental interstitial radiotherapy of intracerebral D-54 MG glioma xenografts in athymic mice.
-
L-selectin is involved in lymphocyte migration to sites of inflammation in the skin: delayed rejection of allografts in L-selectin-deficient mice.
-
LFA-1 binding site in ICAM-3 contains a conserved motif and non-contiguous amino acids.
-
LFA-1 blockade induces effector and regulatory T-cell enrichment in lymph nodes and synergizes with CTLA-4Ig to inhibit effector function.
-
LIF negatively regulates tumour-suppressor p53 through Stat3/ID1/MDM2 in colorectal cancers.
-
LMP-420, a small molecular inhibitor of TNF-α, prolongs islet allograft survival by induction of suppressor of cytokine signaling-1: synergistic effect with cyclosporin-A.
-
LMP2 expression and proteasome activity in NOD mice.
-
LPS-sensory peptide communication in experimental cystitis.
-
Labeling proteins using aryl iodide acylation agents: influence of meta vs para substitution on in vivo stability.
-
Labeling proteins with fluorine-18 using N-succinimidyl 4-[18F]fluorobenzoate.
-
Lactotetraose series ganglioside 3',6'-isoLD1 in tumors of central nervous and other systems in vitro and in vivo.
-
Lasers and microdermabrasion enhance and control topical delivery of vitamin C.
-
Lentiviral gene transduction of kidney.
-
Leprosy in a mangabey monkey--naturally acquired infection.
-
Leptin receptor is expressed in thymus medulla and leptin protects against thymic remodeling during endotoxemia-induced thymus involution.
-
Leptin selectively augments thymopoiesis in leptin deficiency and lipopolysaccharide-induced thymic atrophy.
-
Leukemia inhibitory factor is a mediator of Escherichia coli lipopolysaccharide-induced acute thymic atrophy.
-
Leukemia inhibitory factor, oncostatin M, IL-6, and stem cell factor mRNA expression in human thymus increases with age and is associated with thymic atrophy.
-
Leukocyte entry into sites of inflammation requires overlapping interactions between the L-selectin and ICAM-1 pathways.
-
Levels of Foxp3 in regulatory T cells reflect their functional status in transplantation.
-
Ligand-independent toll-like receptor signals generated by ectopic overexpression of MyD88 generate local and systemic antitumor immunity.
-
Ligation of MHC class I and class II molecules can lead to heterologous desensitization of signal transduction pathways that regulate homotypic adhesion in human lymphocytes.
-
Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer.
-
Lipopolysaccharide upregulates bradykinin 1 receptors in the isolated mouse bladder.
-
Liposomes as antigen delivery systems in viral immunity.
-
Lithium ameliorates nucleus accumbens phase-signaling dysfunction in a genetic mouse model of mania.
-
Local hyperthermia improves uptake of a chimeric monoclonal antibody in a subcutaneous xenograft model.
-
Localisation of [131I]MIBG in nude mice bearing SK-N-SH human neuroblastoma xenografts: effect of specific activity.
-
Long-term in vivo imaging of multiple organs at the single cell level.
-
Loss of allergen 1 confers a hypervirulent phenotype that resembles mucoid switch variants of Cryptococcus neoformans.
-
Luminescent Difluoroboron β-Diketonate PLA-PEG Nanoparticle.
-
Lung inflammation, injury, and proliferative response after repetitive particulate hexavalent chromium exposure.
-
Lung injury, inflammation and Akt signaling following inhalation of particulate hexavalent chromium.
-
Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy.
-
Lymphocyte responses to purified ragweed allergens in vitro. I. Proliferative responses in normal, newborn, agammaglobulinemic, and atopic subjects.
-
Lysophosphatidic acid stimulates neurotransmitter-like conductance changes that precede GABA and L-glutamate in early, presumptive cortical neuroblasts.
-
MAPK signal-integrating kinase controls cap-independent translation and cell type-specific cytotoxicity of an oncolytic poliovirus.
-
MDM2 antagonists overcome intrinsic resistance to CDK4/6 inhibition by inducing p21.
-
MRP3: a molecular target for human glioblastoma multiforme immunotherapy.
-
Machine Learning Uncovers Food- and Excipient-Drug Interactions.
-
Macrophage activation by gastric fluid suggests MMP involvement in aspiration-induced lung disease.
-
Macrophage colony-stimulating factor can modulate immune responses and attract dendritic cells in vivo.
-
Macrophage-dependent induction of the Salmonella pathogenicity island 2 type III secretion system and its role in intracellular survival.
-
Macrophages and cardiac fibroblasts are the main producers of eotaxins and regulate eosinophil trafficking to the heart.
-
Macrophages driven to a novel state of activation have anti-inflammatory properties in mice.
-
Mapping of the mouse Rxr loci encoding nuclear retinoid X receptors RXR alpha, RXR beta, and RXR gamma.
-
Marizomib activity as a single agent in malignant gliomas: ability to cross the blood-brain barrier.
-
Mast cell phagocytosis of FimH-expressing enterobacteria.
-
Maternally inherited peptides as strain-specific chemosignals.
-
Mechanism of anti-glioma activity and in vivo efficacy of the cannabinoid ligand KM-233.
-
Mechanisms of tolerance induced by PG490-88 in a bone marrow transplantation model.
-
Mesenchymal stem cells use integrin beta1 not CXC chemokine receptor 4 for myocardial migration and engraftment.
-
Meta-[211At]astatobenzylguanidine: further evaluation of a potential therapeutic agent.
-
Metabolic engineering of Escherichia coli to produce a monophosphoryl lipid A adjuvant.
-
Metabolic plasticity of metastatic breast cancer cells: adaptation to changes in the microenvironment.
-
Metabolism of O6-benzylguanine, an inactivator of O6-alkylguanine-DNA alkyltransferase.
-
Method for radioiodination of proteins using N-succinimidyl 3-hydroxy-4-iodobenzoate.
-
Methylator resistance mediated by mismatch repair deficiency in a glioblastoma multiforme xenograft.
-
MiR-148a functions to suppress metastasis and serves as a prognostic indicator in triple-negative breast cancer.
-
Mice lacking expression of the chemokines CCL21-ser and CCL19 (plt mice) demonstrate delayed but enhanced T cell immune responses.
-
Mice that overexpress CC chemokine ligand 2 in their lungs show increased protective immunity to infection with Mycobacterium bovis bacille Calmette-Guérin.
-
MicroRNA-17-92 controls T-cell responses in graft-versus-host disease and leukemia relapse in mice.
-
Microarray analysis of murine retinal light damage reveals changes in iron regulatory, complement, and antioxidant genes in the neurosensory retina and isolated RPE.
-
Microdosimetric analysis of alpha-particle-emitting targeted radiotherapeutics using histological images.
-
Microglial Function Is Distinct in Different Anatomical Locations during Retinal Homeostasis and Degeneration.
-
Mincle Signaling Promotes Con A Hepatitis.
-
Modeling Chronic Graft-versus-Host Disease in MHC-Matched Mouse Strains: Genetics, Graft Composition, and Tissue Targets.
-
Modifications of the human immunodeficiency virus envelope glycoprotein enhance immunogenicity for genetic immunization.
-
Modular nanotransporters: a multipurpose in vivo working platform for targeted drug delivery.
-
Modulation of amplitude and direction of in vivo immune responses by co-administration of cytokine gene expression cassettes with DNA immunogens.
-
Modulation of murine breast tumor vascularity, hypoxia and chemotherapeutic response by exercise.
-
Modulation of murine herpes simplex virus type 1 retinitis in the uninoculated eye by CD4+ T lymphocytes.
-
Modulation of nonneutralizing HIV-1 gp41 responses by an MHC-restricted TH epitope overlapping those of membrane proximal external region broadly neutralizing antibodies.
-
Molecular analysis of genetic instability caused by chronic inflammation.
-
Molecular and immunological analysis of genetic prostate specific antigen (PSA) vaccine.
-
Molecular characterization of anti-DNA antibodies induced in normal mice by immunization with bacterial DNA. Differences from spontaneous anti-DNA in the content and location of VH CDR3 arginines.
-
Molecular composition of an antigen-specific, Ly-1 T suppressor inducer factor. One molecule binds antigen and is I-J-; another is I-J+, does not bind antigen, and imparts an Igh-variable region-linked restriction.
-
Molecular imaging of alkylguanine-DNA alkyltransferase: further evaluation of radioiodinated derivatives of O6-benzylguanine.
-
Monoclonal Antibodies, Derived from Humans Vaccinated with the RV144 HIV Vaccine Containing the HVEM Binding Domain of Herpes Simplex Virus (HSV) Glycoprotein D, Neutralize HSV Infection, Mediate Antibody-Dependent Cellular Cytotoxicity, and Protect Mice from Ocular Challenge with HSV-1.
-
Monoclonal antibodies against EGFRvIII are tumor specific and react with breast and lung carcinomas and malignant gliomas.
-
Monoclonal antibodies against human T cell leukemia-lymphoma virus (HTLV) p24 internal core protein. Use as diagnostic probes and cellular localization of HTLV.
-
Monoclonal antibodies binding renal renin.
-
Monoclonal antibodies reactive with human T cell lymphotropic virusI (HTLVI) p19 internal core protein: cross-reactivity with normal tissues and differential reactivity with HTLV types I and II.
-
Monoclonal antibodies to different epitopes on a prostate tumor-associated antigen. Implications for immunotherapy.
-
Monoclonal antibodies to tissue-specific cell surface antigens. I. Characterization of an antibody to a prostate tissue antigen.
-
Monoclonal antibody F(ab')2 fragment labeled with N-succinimidyl 2,4-dimethoxy-3-halobenzoates: in vivo comparison of iodinated and astatinated fragments.
-
Monoclonal antibody recognizing a unique Rh-related specificity.
-
Morphologic and functional studies of mouse hepatocytes in primary culture.
-
Morphological and neoplastic transformation of C3H/10T1/2 Cl 8 mouse embryo cells by insoluble carcinogenic nickel compounds.
-
Morphology of the fibrinogen exudate during evolution of a mycobacterial-induced murine eye granuloma.
-
Most environmental isolates of Cryptococcus neoformans var. grubii (serotype A) are not lethal for mice.
-
Mouse cytomegalovirus reactivation in severe combined immune deficient mice after implantation of latently infected salivary gland.
-
Mouse liver cell culture. I. Hepatocyte isolation.
-
Mouse liver cell culture. II. Primary culture.
-
Mucin is produced by clara cells in the proximal airways of antigen-challenged mice.
-
Mucosal and systemic adjuvant activity of alphavirus replicon particles.
-
Mucosal immunity to HIV-1: systemic and vaginal antibody responses after intranasal immunization with the HIV-1 C4/V3 peptide T1SP10 MN(A).
-
Multiple roles for sialylated glycans in determining the cardiopulmonary tropism of adeno-associated virus 4.
-
Multiprotein HIV type 1 clade B DNA and MVA vaccines: construction, expression, and immunogenicity in rodents of the MVA component.
-
Multistrain genetic comparisons reveal CCR5 as a receptor involved in airway hyperresponsiveness.
-
Multivalent 4-1BB binding aptamers costimulate CD8+ T cells and inhibit tumor growth in mice.
-
Multivalent RNA aptamers that inhibit CTLA-4 and enhance tumor immunity.
-
Murine CD7 shares antigenic cross-reactivity with HSP-60.
-
Murine bone marrow stromal cells pulsed with homologous tumor-derived exosomes inhibit proliferation of liver cancer cells.
-
Murine cytomegalovirus gene amplification and culture after submaxillary salivary gland biopsy.
-
Murine cytomegalovirus infection: hematological, morphological, and functional study of lymphoid cells.
-
Murine granulocyte-macrophage colony-stimulating factor expressed from a bicistronic simian immunodeficiency virus-based integrase-defective lentiviral vector does not enhance T-cell responses in mice.
-
Murine model of pulmonary anthrax: kinetics of dissemination, histopathology, and mouse strain susceptibility.
-
Murine monoclonal antibodies specific for conserved and non-conserved antigenic determinants of the human and murine Ku autoantigens.
-
N-myc can substitute for insulin-like growth factor signaling in a mouse model of sonic hedgehog-induced medulloblastoma.
-
N-succinimidyl 4-methyl-3-(tri-n-butylstannyl)benzoate: synthesis and potential utility for the radioiodination of monoclonal antibodies.
-
N-succinimidyl 5-(trialkylstannyl)-3-pyridinecarboxylates: a new class of reagents for protein radioiodination.
-
NIR-emissive PEG-b-TCL micelles for breast tumor imaging and minimally invasive pharmacokinetic analysis.
-
NOTUM is a potential pharmacodynamic biomarker of Wnt pathway inhibition.
-
Nanoparticle Encapsulation of Synergistic Immune Agonists Enables Systemic Codelivery to Tumor Sites and IFNβ-Driven Antitumor Immunity.
-
Nanoparticle delivery of donor antigens for transplant tolerance in allogeneic islet transplantation.
-
Nanoparticle formulation improves doxorubicin efficacy by enhancing host antitumor immunity.
-
Nasal peptide vaccination elicits CD8 responses and reduces viral burden after challenge with virulent murine cytomegalovirus.
-
Natural IgM Switches the Function of Lipopolysaccharide-Activated Murine Bone Marrow-Derived Dendritic Cells to a Regulatory Dendritic Cell That Suppresses Innate Inflammation.
-
Natural IgM is produced by CD5- plasma cells that occupy a distinct survival niche in bone marrow.
-
Natural allelic variation of the IL-21 receptor modulates ischemic stroke infarct volume.
-
Negative control of mast cell degranulation and the anaphylactic response by the phosphatase lipin1.
-
Neurogenic differentiation of murine and human adipose-derived stromal cells.
-
Neuronal IL-4Rα modulates neuronal apoptosis and cell viability during the acute phases of cerebral ischemia.
-
Neurophenotyping genetically modified mice for social behavior.
-
Neutrophil elastase induces mucus cell metaplasia in mouse lung.
-
New murine cell line derived from a spontaneous lung tumor induces paraneoplastic syndromes.
-
No-carrier-added iodine-131-FIBG: evaluation of an MIBG analog.
-
No-carrier-added meta-[123I]iodobenzylguanidine: synthesis and preliminary evaluation.
-
No-carrier-added synthesis of meta-[131I]iodobenzylguanidine.
-
Non-viral DNA delivery from porous hyaluronic acid hydrogels in mice.
-
Noninvasive visualization of retinoblastoma growth and metastasis via bioluminescence imaging.
-
Nonmucosal alphavirus vaccination stimulates a mucosal inductive environment in the peripheral draining lymph node.
-
Noradrenergic induction of odor-specific neural habituation and olfactory memories.
-
Notch signaling mediated by Delta-like ligands 1 and 4 controls the pathogenesis of chronic GVHD in mice.
-
Novel ACE2-Fc chimeric fusion provides long-lasting hypertension control and organ protection in mouse models of systemic renin angiotensin system activation.
-
Novel intranasal pertussis vaccine based on bacterium-like particles as a mucosal adjuvant.
-
Novel mechanism of rapamycin in GVHD: increase in interstitial regulatory T cells.
-
Novel sphingosine-1-phosphate receptor modulator KRP203 combined with locally delivered regulatory T cells induces permanent acceptance of pancreatic islet allografts.
-
Novel strategies to augment genetically delivered immunotoxin molecular therapy for cancer therapy.
-
Nuclear factor kappa B activation is a potential target for preventing pancreatic carcinoma by aspirin.
-
Nuclear factor kappa B mediates lipopolysaccharide-induced inflammation in the urinary bladder.
-
Nuclear factor-kappaB maintains TRAIL resistance in human pancreatic cancer cells.
-
Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy.
-
O6-3-[131I]iodobenzylguanine: improved synthesis and further evaluation of a potential agent for imaging of alkylguanine-DNA alkyltransferase.
-
O6-benzylguanine-mediated enhancement of chemotherapy.
-
O6-benzylguanine-mediated enhancement of nitrosourea activity in Mer- central nervous system tumor xenografts--implications for clinical trials.
-
OCD-Like behaviors caused by a neuropotentiating transgene targeted to cortical and limbic D1+ neurons.
-
Obesity-Induced Colorectal Cancer Is Driven by Caloric Silencing of the Guanylin-GUCY2C Paracrine Signaling Axis.
-
Of mice, birds, and men: the mouse ultrasonic song system has some features similar to humans and song-learning birds.
-
Oncolytic adenovirus delivering herpes simplex virus thymidine kinase suicide gene reduces the growth of human retinoblastoma in an in vivo mouse model.
-
Oncostatin M enhances CCL21 expression by microvascular endothelial cells and increases the efficiency of dendritic cell trafficking to lymph nodes.
-
Opposing actions of Stat1 and Stat6 on IL-13-induced up-regulation of early growth response-1 and platelet-derived growth factor ligands in pulmonary fibroblasts.
-
Optimization of a murine immunization model for study of PF4/heparin antibodies.
-
Oral immunogenicity of the plant proteinase bromelain.
-
Oral vaccine models: multiple delivery systems employing tetanus toxoid.
-
Organ distribution of Corynebacterium parvum labeled with iodine-125.
-
Osteoblasts produce monocyte chemoattractant protein-1 in a murine model of Staphylococcus aureus osteomyelitis and infected human bone tissue.
-
Osteopontin deficiency ameliorates Alport pathology by preventing tubular metabolic deficits.
-
Osteopontin silencing by small interfering RNA suppresses in vitro and in vivo CT26 murine colon adenocarcinoma metastasis.
-
Overexpression of tropomysin-related kinase B in metastatic human pancreatic cancer cells.
-
Oxidative damage-induced inflammation initiates age-related macular degeneration.
-
PD-1-dependent restoration of self-tolerance in the NOD mouse model of diabetes after transient anti-TCRβ mAb therapy.
-
PF4/heparin complexes are T cell-dependent antigens.
-
PG27, an extract of Tripterygium wilfordii hook f, induces antigen-specific tolerance in bone marrow transplantation in mice.
-
Partial denervation of sub-basal axons persists following debridement wounds to the mouse cornea.
-
Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration.
-
Partial suppression of anchorage-independent growth and tumorigenicity in immunodeficient mice by transfection of the H-2 class I gene H-2Ld into a human colon cancer cell line (HCT).
-
Pathogenicity of human anti-platelet factor 4 (PF4)/heparin in vivo: generation of mouse anti-PF4/heparin and induction of thrombocytopenia by heparin.
-
Peptide-conjugated PAMAM dendrimer as a universal DNA vaccine platform to target antigen-presenting cells.
-
Perforin knockout mice, but not mice with MAIDS, show protection against experimental cytomegalovirus retinitis after adoptive transfer of immune cells with a functional perforin cytotoxic pathway.
-
Peripheral nerve repair with bioresorbable prosthesis.
-
Permanent protection of PLG scaffold transplanted allogeneic islet grafts in diabetic mice treated with ECDI-fixed donor splenocyte infusions.
-
Permanent survival of fully MHC-mismatched islet allografts by targeting a single chemokine receptor pathway.
-
Permeability of different experimental brain tumor models to horseradish peroxidase.
-
Peroxide detoxification affecting the production of immunoglobulin by mouse myeloma tumor cells in vitro.
-
Persistent genetic instability in cancer cells induced by non-DNA-damaging stress exposures.
-
Pharmacokinetics and radiation dosimetry of 18F-fluorocholine.
-
Pharmacokinetics of combined gene therapy expressing constitutive human GM-CSF and hyperthermia-regulated human IL-12.
-
Pharmacokinetics of radiolabeled monoclonal antibody B6.2 in patients with metastatic breast cancer.
-
Phase 1 gene therapy for Duchenne muscular dystrophy using a translational optimized AAV vector.
-
Phenotypic and functional maturation of dendritic cells mediated by heparan sulfate.
-
Phenotypic characterization and ontogeny of mesodermal-derived and endocrine epithelial components of the human thymic microenvironment.
-
Phosphoethanolamine decoration of Neisseria gonorrhoeae lipid A plays a dual immunostimulatory and protective role during experimental genital tract infection.
-
Phosphorylation of Glutathione S-Transferase P1 (GSTP1) by Epidermal Growth Factor Receptor (EGFR) Promotes Formation of the GSTP1-c-Jun N-terminal kinase (JNK) Complex and Suppresses JNK Downstream Signaling and Apoptosis in Brain Tumor Cells.
-
Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles.
-
Plasminogen alleles influence susceptibility to invasive aspergillosis.
-
Platelet factor 4-heparin complexes trigger immune responses independently of the MyD88 pathway.
-
Platelet-derived growth factor receptors form a high affinity state in membrane preparations. Kinetics and affinity cross-linking studies.
-
Platelet-derived or soluble CD154 induces vascularized allograft rejection independent of cell-bound CD154.
-
Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair-deficient malignant glioma xenograft.
-
Polyfunctional anti-human epidermal growth factor receptor 3 (anti-HER3) antibodies induced by HER3 vaccines have multiple mechanisms of antitumor activity against therapy resistant and triple negative breast cancers.
-
Polyhexamethylene biguanide and calcineurin inhibitors as novel antifungal treatments for Aspergillus keratitis.
-
Polyspecific binding of Escherichia coli beta-galactosidase by murine antibodies to DNA.
-
Positive therapeutic interaction between thiopurines and alkylating drugs in human glioma xenografts.
-
Postexposure immunoprophylaxis of primary isolates by an antibody to HIV receptor complex.
-
Preemptive Tolerogenic Delivery of Donor Antigens for Permanent Allogeneic Islet Graft Protection.
-
Preemptive donor apoptotic cell infusions induce IFN-γ-producing myeloid-derived suppressor cells for cardiac allograft protection.
-
Preparation and characterization of anti-tenascin monoclonal antibody-streptavidin conjugates for pretargeting applications.
-
Preparation and preliminary evaluation of 4-[211At]astato-N-piperidinoethyl benzamide.
-
Prevention of graft-versus-host disease by a novel immunosuppressant, PG490-88, through inhibition of alloreactive T cell expansion.
-
Prevention of herpes keratitis by monoclonal antibodies specific for discontinuous and continuous epitopes on glycoprotein D.
-
Primary vascularization of the graft determines the immunodominance of murine minor H antigens during organ transplantation.
-
Priming of anti-human immunodeficiency virus (HIV) CD8+ cytotoxic T cells in vivo by carrier-free HIV synthetic peptides.
-
Production and characterization of two ependymoma xenografts.
-
Production of monoclonal antibodies reacting with peripheral blood mononuclear cell surface differentiation antigens.
-
Production of monoclonal antibody alpha Pro3 recognizing a human prostatic carcinoma antigen.
-
Profiling Hsp90 differential expression and the molecular effects of the Hsp90 inhibitor IPI-504 in high-grade glioma models.
-
Programming the magnitude and persistence of antibody responses with innate immunity.
-
Proinflammatory actions of thromboxane receptors to enhance cellular immune responses.
-
Promoter analysis of Zfp-36, the mitogen-inducible gene encoding the zinc finger protein tristetraprolin.
-
Protamine is an antagonist of apelin receptor, and its activity is reversed by heparin.
-
Proteasome inhibition with bortezomib induces cell death in GBM stem-like cells and temozolomide-resistant glioma cell lines, but stimulates GBM stem-like cells' VEGF production and angiogenesis.
-
Protection against cryptococcosis by using a murine gamma interferon-producing Cryptococcus neoformans strain.
-
Protection elicited by two glutamine auxotrophs of Mycobacterium tuberculosis and in vivo growth phenotypes of the four unique glutamine synthetase mutants in a murine model.
-
Protection of mice from Semliki Forest virus infection by lymphocytes treated with low levels of interferon.
-
Protein tyrosine phosphatase-σ regulates hematopoietic stem cell-repopulating capacity.
-
Proteomic profiling of patient-derived glioblastoma xenografts identifies a subset with activated EGFR: implications for drug development.
-
Pseudomonas exotoxin A mutants. Replacement of surface exposed residues in domain II with cysteine residues that can be modified with polyethylene glycol in a site-specific manner.
-
Qa-1, a nonclassical MHC molecule with immunomodulatory functions, is ubiquitously expressed in the immune-privileged anterior chamber of the eye.
-
RANK, RANKL, OPG, and M-CSF expression in stromal cells during corneal wound healing.
-
RNA Aptamer-targeted Inhibition of NF-κB Suppresses Non-small Cell Lung Cancer Resistance to Doxorubicin.
-
RNA inhibitors of nuclear proteins responsible for multiple organ dysfunction syndrome.
-
RU486 blocks the anti-inflammatory effects of exercise in a murine model of allergen-induced pulmonary inflammation.
-
Radiation-Mediated Tumor Growth Inhibition Is Significantly Enhanced with Redox-Active Compounds That Cycle with Ascorbate.
-
Radiohalogenation of a monoclonal antibody using an N-succinimidyl 3-(tri-n-butylstannyl)benzoate intermediate.
-
Radioimmunotargeting of malignant glioma by monoclonal antibody D2C7 reactive against both wild-type and variant III mutant epidermal growth factor receptors.
-
Radioiodinated antibody targeting of the HER-2/neu oncoprotein.
-
Radioiodinated antibody targeting of the HER-2/neu oncoprotein: effects of labeling method on cellular processing and tissue distribution.
-
Radioiodination of a monoclonal antibody using N-succinimidyl 5-iodo-3-pyridinecarboxylate.
-
Radioiodination of antibodies via N-succinimidyl 2,4-dimethoxy-3-(trialkylstannyl)benzoates.
-
Radioiodination of internalizing monoclonal antibodies using N-succinimidyl 5-iodo-3-pyridinecarboxylate.
-
Radioiodination of proteins using N-succinimidyl 4-hydroxy-3-iodobenzoate.
-
Radioiodination via D-amino acid peptide enhances cellular retention and tumor xenograft targeting of an internalizing anti-epidermal growth factor receptor variant III monoclonal antibody.
-
Radiolocalization of human mammary tumors in athymic mice by a monoclonal antibody.
-
Radiotoxicity of systematically administered [211At]astatide in B6C3F1 and BALB/c (nu/nu) mice: a long-term survival study with histologic analysis.
-
Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans.
-
Rapid identification of monospecific monoclonal antibodies using a human proteome microarray.
-
Rapid memory CD8+ T-lymphocyte induction through priming with recombinant Mycobacterium smegmatis.
-
Reagents for astatination of biomolecules: comparison of the in vivo distribution and stability of some radioiodinated/astatinated benzamidyl and nido-carboranyl compounds.
-
Receptor tyrosine kinase MerTK suppresses an allogenic type I IFN response to promote transplant tolerance.
-
Recipient Myd88 Deficiency Promotes Spontaneous Resolution of Kidney Allograft Rejection.
-
Recombinant HIV-1 vaccine candidates based on replication-defective flavivirus vector.
-
Recombinant Mycobacterium bovis bacillus Calmette-Guerin elicits human immunodeficiency virus type 1 envelope-specific T lymphocytes at mucosal sites.
-
Recombinant oncolytic poliovirus eliminates glioma in vivo without genetic adaptation to a pathogenic phenotype.
-
Recombinant oncolytic poliovirus, PVSRIPO, has potent cytotoxic and innate inflammatory effects, mediating therapy in human breast and prostate cancer xenograft models.
-
Redundancy renders the glycoprotein 96 receptor scavenger receptor A dispensable for cross priming in vivo.
-
Regional effects of an antivascular endothelial growth factor receptor monoclonal antibody on receptor phosphorylation and apoptosis in human 253J B-V bladder cancer xenografts.
-
Regulation of basement membrane-reactive B cells in BXSB, (NZBxNZW)F1, NZB, and MRL/lpr lupus mice.
-
Regulation of blood vessel versus lymphatic vessel growth in the cornea.
-
Regulation of human CD44H and CD44E isoform binding to hyaluronan by phorbol myristate acetate and anti-CD44 monoclonal and polyclonal antibodies.
-
Regulation of mucosal and systemic antibody responses by T helper cell subsets, macrophages, and derived cytokines following oral immunization with live recombinant Salmonella.
-
Regulation of the immune response. I. Regulatory cell equilibrium in the "virgin" state.
-
Regulation of the tyrosine kinase-dependent adhesion pathway in human lymphocytes through CD45.
-
Regulatory Mechanism of the Atypical AP-1-Like Transcription Factor Yap1 in Cryptococcus neoformans.
-
Rejection of kidney allografts by MHC class I-deficient mice.
-
Relaxin treatment of solid tumors: effects on electric field-mediated gene delivery.
-
Requirements for prolongation of allograft survival with regulatory T cell infusion in lymphosufficient hosts.
-
Responses of vascular endothelial cells to angiogenic signaling are important for tumor cell survival.
-
Retinal degeneration in the rd mouse is caused by a defect in the beta subunit of rod cGMP-phosphodiesterase.
-
Retinitis in euthymic mice following inoculation of murine cytomegalovirus (MCMV) via the supraciliary route.
-
Retinoblastoma protein monoclonal antibodies with novel characteristics.
-
Retroviral protein P15E and tumorigenesis. Expression is neither required nor sufficient for tumor development.
-
Retrovirus-elicited interleukin-12 and tumour necrosis factor-alpha as inducers of interferon-gamma-mediated pathology in mouse AIDS.
-
Reversing the Warburg effect as a treatment for glioblastoma.
-
Rh-related antigen CD47 is the signal-transducer integrin-associated protein.
-
Rho kinase promotes alloimmune responses by regulating the proliferation and structure of T cells.
-
Rodent model of reproductive tract leiomyomata. Clinical and pathological features.
-
Role for thromboxane receptors in angiotensin-II-induced hypertension.
-
Role of CCR7 in facilitating direct allosensitization and regulatory T-cell function in high-risk corneal transplantation.
-
Role of T cell recruitment and chemokine-regulated intra-graft T cell motility patterns in corneal allograft rejection.
-
Role of T-bet in commitment of TH1 cells before IL-12-dependent selection.
-
Role of interleukin 12 and costimulators in T cell anergy in vivo.
-
Role of macrophages in restricting herpes simplex virus type 1 growth after ocular infection.
-
Role of macrophages in the generation of circulating blood nucleosomes from dead and dying cells.
-
Role of mast cell leukotrienes in neutrophil recruitment and bacterial clearance in infectious peritonitis.
-
Role of the heat shock protein 90 in immune response stimulation by bacterial DNA and synthetic oligonucleotides.
-
Runx2/Cbfa1-genetically engineered skeletal myoblasts mineralize collagen scaffolds in vitro.
-
S1P-Dependent trafficking of intracellular yersinia pestis through lymph nodes establishes Buboes and systemic infection.
-
SIB-DOTA: a trifunctional prosthetic group potentially amenable for multi-modal labeling that enhances tumor uptake of internalizing monoclonal antibodies.
-
Salmonella efficiently enter and survive within cultured CD11c+ dendritic cells initiating cytokine expression.
-
Scaffold Hopping and Optimization of Maleimide Based Porcupine Inhibitors.
-
Schedule-dependent activity of irinotecan plus BCNU against malignant glioma xenografts.
-
Schedule-dependent activity of temozolomide plus CPT-11 against a human central nervous system tumor-derived xenograft.
-
Schisis contributes to necrosis in experimental HSV-1 retinitis.
-
Selection of TCR V alpha by MHC class II predicts superantigen reactivity.
-
Selective expansion of allogeneic regulatory T cells by hepatic stellate cells: role of endotoxin and implications for allograft tolerance.
-
Self-assembling chimeric polypeptide-doxorubicin conjugate nanoparticles that abolish tumours after a single injection.
-
Separation of the acetylcholinesterase-deficient red cells in paroxysmal nocturnal hemoglobinuria.
-
Shifting priorities: highly conserved behavioral and brain network adaptations to chronic stress across species.
-
Short-chain acyl-coenzyme A dehydrogenase deficiency in mice.
-
Simian immunodeficiency virus-Vpx for improving integrase defective lentiviral vector-based vaccines.
-
Similar T-cell immune responses induced by group M consensus env immunogens with wild-type or minimum consensus variable regions.
-
Simultaneous measurements of blood flow and blood-to-tissue transport in xenotransplanted medulloblastomas.
-
Single amino acid modification of adeno-associated virus capsid changes transduction and humoral immune profiles.
-
Skeletal muscle-specific genetic determinants contribute to the differential strain-dependent effects of hindlimb ischemia in mice.
-
Skin allograft rejection and hyperbaric oxygen treatment in immune-histoincompatible mice.
-
Some fixation reagents reduce or abolish the detectability of Ia-antigen and HLA-DR on cells.
-
Sorafenib suppresses postsurgical recurrence and metastasis of hepatocellular carcinoma in an orthotopic mouse model.
-
Space flight alters bacterial gene expression and virulence and reveals a role for global regulator Hfq.
-
Spatiotemporally photoradiation-controlled intratumoral depot for combination of brachytherapy and photodynamic therapy for solid tumor.
-
Specific and high-level targeting of radiolabeled octreotide analogues to human medulloblastoma xenografts.
-
Specific chromosomal abnormalities characterize four established cell lines derived from malignant human gliomas.
-
Specificity and idiotype analysis of a monoclonal anti-DNA antibody.
-
Specificity and idiotypic analysis of a monoclonal anti-Sm antibody with anti-DNA activity.
-
Specificity and immunochemical properties of anti-DNA antibodies induced in normal mice by immunization with mammalian DNA with a CpG oligonucleotide as adjuvant.
-
Specificity of anti-DNA antibodies induced in normal mice by immunization with bacterial DNA.
-
Spink2 modulates apoptotic susceptibility and is a candidate gene in the Rgcs1 QTL that affects retinal ganglion cell death after optic nerve damage.
-
Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis.
-
Stability and in vivo behavior of Rh[16aneS4-diol]211 at complex: a potential precursor for astatine radiopharmaceuticals.
-
Star nanoparticles delivering HIV-1 peptide minimal immunogens elicit near-native envelope antibody responses in nonhuman primates.
-
Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis.
-
Stimulation of in vitro proliferation of murine lymphocytes by synthetic oligodeoxynucleotides.
-
Stimulation of murine lymphocyte proliferation by a phosphorothioate oligonucleotide with antisense activity for herpes simplex virus.
-
Stochastic pairing of heavy-chain and kappa light-chain variable gene families occurs in polyclonally activated B cells.
-
Stress affects uterine receptivity through an ovarian-independent pathway.
-
Stromal Fibroblasts Mediate Anti-PD-1 Resistance via MMP-9 and Dictate TGFβ Inhibitor Sequencing in Melanoma.
-
Structural and immunologic correlates of chemically stabilized HIV-1 envelope glycoproteins.
-
Structural basis for the proinflammatory cytokine activity of high mobility group box 1.
-
Structure-guided evolution of antigenically distinct adeno-associated virus variants for immune evasion.
-
Studies on the mechanism and specificity of the effect of the synthetic random copolymer GLAT on graft-versus-host disease.
-
Subacute limb ischemia induces skeletal muscle injury in genetically susceptible mice independent of vascular density.
-
Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus.
-
Suppression of human corneal epithelial proliferation with breast carcinoma immunotoxin.
-
Suppression of inflammatory corneal lymphangiogenesis by application of topical corticosteroids.
-
Survival of FimH-expressing enterobacteria in macrophages relies on glycolipid traffic.
-
Survivin DNA vaccine generated specific antitumor effects in pancreatic carcinoma and lymphoma mouse models.
-
Sym004-induced EGFR elimination is associated with profound anti-tumor activity in EGFRvIII patient-derived glioblastoma models.
-
Syndecans, cell surface heparan sulfate proteoglycans, are induced by a proline-rich antimicrobial peptide from wounds.
-
Synephrine Hydrochloride Suppresses Esophageal Cancer Tumor Growth and Metastatic Potential through Inhibition of Galectin-3-AKT/ERK Signaling.
-
Synergism from combined immunologic and pharmacologic inhibition of HER2 in vivo.
-
Synergistic cytotoxicity with 2'-deoxy-5-azacytidine and topotecan in vitro and in vivo.
-
Synergistic interaction between anti-p185HER-2 ricin A chain immunotoxins and radionuclide conjugates for inhibiting growth of ovarian and breast cancer cells that overexpress HER-2.
-
Synergistic interactions between cyclophosphamide or melphalan and VP-16 in a human rhabdomyosarcoma xenograft.
-
Synthesis and Preliminary Evaluation of 5-[18F]fluoroleucine.
-
Synthesis and evaluation of (18)F-labeled choline analogs as oncologic PET tracers.
-
Synthesis and evaluation of 18F-labeled choline as an oncologic tracer for positron emission tomography: initial findings in prostate cancer.
-
Synthesis and evaluation of 4-[18F]fluoropropoxy-3-iodobenzylguanidine ([18F]FPOIBG): A novel 18F-labeled analogue of MIBG.
-
Synthesis and preliminary biological evaluation of (3-iodobenzoyl)norbiotinamide and ((5-iodo-3-pyridinyl)carbonyl)norbiotinamide: two radioiodinated biotin conjugates with improved stability.
-
Synthesis of polymerized melanin by Cryptococcus neoformans in infected rodents.
-
Synthetic mast-cell granules as adjuvants to promote and polarize immunity in lymph nodes.
-
Systemic production of human granulocyte colony-stimulating factor in nonhuman primates by transplantation of genetically modified myoblasts.
-
Systemic soluble Tie2 expression inhibits and regresses corneal neovascularization.
-
Systemic vector leakage and transgene expression by intratumorally injected recombinant adenovirus vectors.
-
T cell depletion increases susceptibility to murine cytomegalovirus retinitis.
-
T cell inactivation by poxviral B22 family proteins increases viral virulence.
-
T cell receptor excision circle assessment of thymopoiesis in aging mice.
-
T helper 2-dominant antilymphoma immune response is associated with fatal outcome.
-
T-bet-dependent expression of osteopontin contributes to T cell polarization.
-
TCR stimulation without co-stimulatory signals induces expression of "tolerogenic" genes in memory CD4 T cells but does not compromise cell proliferation.
-
TLR9 agonist acts by different mechanisms synergizing with bevacizumab in sensitive and cetuximab-resistant colon cancer xenografts.
-
Targeted overexpression of phospholamban to mouse atrium depresses Ca2+ transport and contractility.
-
Targeted suppression of beta-catenin blocks intestinal adenoma formation in APC Min mice.
-
Targeting Fluorescent Nanodiamonds to Vascular Endothelial Growth Factor Receptors in Tumor.
-
Targeting a genetically engineered elastin-like polypeptide to solid tumors by local hyperthermia.
-
Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice.
-
Testing of the topoisomerase 1 inhibitor Genz-644282 by the pediatric preclinical testing program.
-
Tetraspanin CD37 protects against the development of B cell lymphoma.
-
Thalamic relay of spontaneous retinal activity prior to vision.
-
The 40-kilodalton allergen of Candida albicans is an alcohol dehydrogenase: molecular cloning and immunological analysis using monoclonal antibodies.
-
The 5' non-coding region of the BCR/ABL oncogene augments its ability to stimulate the growth of immature lymphoid cells.
-
The B-cell repertoire for autoantibodies: frequency of precursor cells for anti-DNA antibodies.
-
The CC chemokine thymus-derived chemotactic agent 4 (TCA-4, secondary lymphoid tissue chemokine, 6Ckine, exodus-2) triggers lymphocyte function-associated antigen 1-mediated arrest of rolling T lymphocytes in peripheral lymph node high endothelial venules.
-
The Caspase-3/PKCδ/Akt/VEGF-A Signaling Pathway Mediates Tumor Repopulation during Radiotherapy.
-
The Chlamydia-Secreted Protease CPAF Promotes Chlamydial Survival in the Mouse Lower Genital Tract.
-
The Mycobacterium tuberculosis 71-kDa heat-shock protein induces proliferation and cytokine secretion by murine gut intraepithelial lymphocytes.
-
The PapG tip adhesin of P fimbriae protects Escherichia coli from neutrophil bactericidal activity.
-
The STE12alpha homolog is required for haploid filamentation but largely dispensable for mating and virulence in Cryptococcus neoformans.
-
The activity of camptothecin analogues is enhanced in histocultures of human tumors and human tumor xenografts by modulation of extracellular pH.
-
The antibody response of normal mice to immunization with single-stranded DNA of various species origin.
-
The common gamma-chain of cytokine receptors regulates intrathymic T cell development at multiple stages.
-
The cytolytic molecules Fas ligand and TRAIL are required for murine thymic graft-versus-host disease.
-
The effect of an amino acid-lowering diet on the rate of melphalan entry into brain and xenotransplanted glioma.
-
The effect of dexamethasone on the generation of plasma DNA from dead and dying cells.
-
The effect of dietary sodium and fructose intake on urine and serum parameters of stone formation in a pediatric mouse model: a pilot study.
-
The effect of inflammation on the generation of plasma DNA from dead and dying cells in the peritoneum.
-
The effect of laser treatment on skin to enhance and control transdermal delivery of 5-fluorouracil.
-
The effect of xenoreactive antibody and B cell depletion on hyperacute rejection of guinea pig-to-rat cardiac xenografts.
-
The effects of ZD6474, an inhibitor of VEGF signaling, on cutaneous wound healing in mice.
-
The expression of plasma nucleosomes in mice undergoing in vivo apoptosis.
-
The fine specificity of monoclonal anti-DNA antibodies induced in normal mice by immunization with bacterial DNA.
-
The generation of extracellular DNA in SLE: the role of death and sex.
-
The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function.
-
The growth-dependent expression of angiotensin II type 2 receptor is regulated by transcription factors interferon regulatory factor-1 and -2.
-
The heat shock response and chaperones/heat shock proteins in brain tumors: surface expression, release, and possible immune consequences.
-
The heritability of antinociception: common pharmacogenetic mediation of five neurochemically distinct analgesics.
-
The human thymic microenvironment. Phenotypic characterization of Hassall's bodies with the use of monoclonal antibodies.
-
The human thymic microenvironment: cortical thymic epithelium is an antigenically distinct region of the thymic microenvironment.
-
The influence of DNA structure on the in vitro stimulation of murine lymphocytes by natural and synthetic polynucleotide antigens.
-
The influence of base sequence on the immunological properties of defined oligonucleotides.
-
The influence of lipofectin on the in vitro stimulation of murine spleen cells by bacterial DNA and plasmid DNA vectors.
-
The influence of variable-region somatic mutations on the specificity and pathogenicity of murine monoclonal anti-DNA antibodies.
-
The mast cell tumor necrosis factor alpha response to FimH-expressing Escherichia coli is mediated by the glycosylphosphatidylinositol-anchored molecule CD48.
-
The mouse retinoid-X receptor-gamma gene: genomic organization and evidence for functional isoforms.
-
The n-hexane and chloroform fractions of Piper betle L. trigger different arms of immune responses in BALB/c mice and exhibit antifilarial activity against human lymphatic filarid Brugia malayi.
-
The neurotoxin quinolinic acid is increased in spinal cords of mice with herpes simplex virus encephalitis.
-
The pediatric preclinical testing program: description of models and early testing results.
-
The radiation dose-response relationship in a human glioma xenograft and an evaluation of the influence of glutathione depletion by buthionine sulfoximine.
-
The relationship between apoptosis and high-mobility group protein 1 release from murine macrophages stimulated with lipopolysaccharide or polyinosinic-polycytidylic acid.
-
The release of DNA into the plasma of mice following hepatic cell death by apoptosis and necrosis.
-
The role of ACAID and CD4+CD25+FOXP3+ regulatory T cells on CTL function against MHC alloantigens.
-
The role of an autoantigen, histidyl-tRNA synthetase, in the induction and maintenance of autoimmunity.
-
The role of cpg sequences in the induction of anti-DNA antibodies.
-
The role of microparticles in the generation of immune complexes in murine lupus.
-
The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: increased nitric oxide production and nitric oxide synthase expression in MRL-lpr/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally administered NG-monomethyl-L-arginine.
-
The role of the macrophage scavenger receptor in immune stimulation by bacterial DNA and synthetic oligonucleotides.
-
The same epitope on CD22 of B lymphocytes mediates the adhesion of erythrocytes, T and B lymphocytes, neutrophils, and monocytes.
-
The serogroup B meningococcal outer membrane vesicle-based vaccine 4CMenB induces cross-species protection against Neisseria gonorrhoeae.
-
The source of murine cytomegalovirus in mice receiving kidney allografts.
-
The structure of the trabecular meshwork, its connections to the ciliary muscle, and the effect of pilocarpine on outflow facility in mice.
-
The synthetic phosphagen cyclocreatine phosphate inhibits the growth of a broad spectrum of solid tumors.
-
The tetraspanin CD81 regulates the expression of CD19 during B cell development in a postendoplasmic reticulum compartment.
-
The trehalose synthesis pathway is an integral part of the virulence composite for Cryptococcus gattii.
-
The type III transforming growth factor-beta receptor as a novel tumor suppressor gene in prostate cancer.
-
The use of fluorometric assays to assess the immune response to DNA in murine systemic lupus erythematosus.
-
Therapeutic activity of 7-[(2-trimethylsilyl)ethyl)]-20 (S)-camptothecin against central nervous system tumor-derived xenografts in athymic mice.
-
Therapeutic analysis of melphalan-resistant human rhabdomyosarcoma xenograft TE-671 MR.
-
Therapeutic efficacy of the topoisomerase I inhibitor 7-ethyl-10-(4-[1-piperidino]-1-piperidino)-carbonyloxy-camptothecin against pediatric and adult central nervous system tumor xenografts.
-
Therapeutic efficacy of vinorelbine against pediatric and adult central nervous system tumors.
-
Therapeutic profile of the human glioma line D-54 MG in athymic mice.
-
Thermal cycling enhances the accumulation of a temperature-sensitive biopolymer in solid tumors.
-
Thioredoxin mitigates radiation-induced hematopoietic stem cell injury in mice.
-
Thrombospondin-1 derived from APCs regulates their capacity for allosensitization.
-
Thymic requirement for cyclical idiotypic and reciprocal anti-idiotypic immune responses to a T-independent antigen.
-
Tie2 expression and phosphorylation in angiogenic and quiescent adult tissues.
-
Transdermal delivery of macromolecules by erbium:YAG laser.
-
Transdermal drug delivery enhanced and controlled by erbium:YAG laser: a comparative study of lipophilic and hydrophilic drugs.
-
Transfection efficiency and transgene expression kinetics of mRNA delivered in naked and nanoparticle format.
-
Transfer of allogeneic CD62L- memory T cells without graft-versus-host disease.
-
Transferrin is a major determinant of hepcidin expression in hypotransferrinemic mice.
-
Transferrin is required for early T-cell differentiation.
-
Transient combination therapy targeting the immune synapse abrogates T cell responses and prolongs allograft survival in mice.
-
Transmission of latent cytomegalovirus in a murine kidney tissue transplantation model.
-
Treatment of Cyclosporin A retains host defense against invasive pulmonary aspergillosis in a non-immunosuppressive murine model by preserving the myeloid cell population.
-
Treatment of subcutaneous and intracranial brain tumor xenografts with O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea.
-
Treatment with a laminin-derived peptide suppresses lupus nephritis.
-
Trefoil factor 1 acts to suppress senescence induced by oncogene activation during the cellular transformation process.
-
Tryptophan hydroxylase 2 genotype determines brain serotonin synthesis but not tissue content in C57Bl/6 and BALB/c congenic mice.
-
Tumor accumulation, degradation and pharmacokinetics of elastin-like polypeptides in nude mice.
-
Tumor immunotherapy targeting fibroblast activation protein, a product expressed in tumor-associated fibroblasts.
-
Tumor microvascular permeability is a key determinant for antivascular effects of doxorubicin encapsulated in a temperature sensitive liposome.
-
Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers.
-
Tumor-dendritic cell fusion as a basis for cancer immunotherapy.
-
Two mouse early embryonic beta-globin gene sequences. Evolution of the nonadult beta-globins.
-
Type III TGF-β receptor downregulation generates an immunotolerant tumor microenvironment.
-
Type III TGF-β receptor enhances colon cancer cell migration and anchorage-independent growth.
-
Ultrafine carbon black particles enhance respiratory syncytial virus-induced airway reactivity, pulmonary inflammation, and chemokine expression.
-
Unaltered graft survival and intragraft lymphocytes infiltration in the cardiac allograft of Cxcr3-/- mouse recipients.
-
Unique glycan signatures regulate adeno-associated virus tropism in the developing brain.
-
Up-regulated P21CIP1 expression is part of the regulation quantitatively controlling serum deprivation-induced apoptosis.
-
Urease as a virulence factor in experimental cryptococcosis.
-
Use of bioluminescence imaging to detect enhanced hepatic and systemic tumor growth following partial hepatectomy in mice.
-
Use of etoposide in combination with cyclosporin for purging multidrug-resistant leukemic cells from bone marrow in a mouse model.
-
Use of in vivo bioluminescence imaging to predict hepatic tumor burden in mice.
-
Use of murine models of cytokine-secreting tumor vaccines to study feasibility and toxicity issues critical to designing clinical trials.
-
Use of site-directed mutagenesis to enhance the epitope-shielding effect of covalent modification of proteins with polyethylene glycol.
-
VEGF inhibits T-cell development and may contribute to tumor-induced immune suppression.
-
Vaccination with Vaxfectin(®) adjuvanted SIV DNA induces long-lasting humoral immune responses able to reduce SIVmac251 Viremia.
-
Vaccination with Venezuelan equine encephalitis replicons encoding cowpox virus structural proteins protects mice from intranasal cowpox virus challenge.
-
Vaccination with the immediate-early protein ICP47 of herpes simplex virus-type 1 (HSV-1) induces virus-specific lymphoproliferation, but fails to protect against lethal challenge.
-
Vaccine-Induced Memory CD8+ T Cells Provide Clinical Benefit in HER2 Expressing Breast Cancer: A Mouse to Human Translational Study.
-
Validation of 4-[fluorine-18]fluoro-3-iodobenzylguanidine as a positron-emitting analog of MIBG.
-
Vanilloid (capsaicin) receptors influence inflammatory sensitivity in response to particulate matter.
-
Variation in chromosome copy number influences the virulence of Cryptococcus neoformans and occurs in isolates from AIDS patients.
-
Viral and bacterial infections induce expression of multiple NK cell receptors in responding CD8(+) T cells.
-
Viral-induced CD28 loss evokes costimulation independent alloimmunity.
-
Virulence and viremia characteristics of 1992 epizootic subtype IC Venezuelan equine encephalitis viruses and closely related enzootic subtype ID strains.
-
Virulence factors identified by Cryptococcus neoformans mutant screen differentially modulate lung immune responses and brain dissemination.
-
Virulence of endemic nonpigmented northern Australian Staphylococcus aureus clone (clonal complex 75, S. argenteus) is not augmented by staphyloxanthin.
-
Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination.
-
Zinc acetate/carrageenan gels exhibit potent activity in vivo against high-dose herpes simplex virus 2 vaginal and rectal challenge.
-
[Experimental studies on human lung cancer gene-therapy with HSV-TK/GCV system].
-
[Intraportal injection of specific monoclonal antibody in nude mice with liver metastasis].
-
c-Myc is required for maintenance of glioma cancer stem cells.
-
miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis.
-
mig-14 is a horizontally acquired, host-induced gene required for salmonella enterica lethal infection in the murine model of typhoid fever.
-
p38α mitogen-activated protein kinase depletion and repression of signal transduction to translation machinery by miR-124 and -128 in neurons.
-
sCD44 overexpression increases intraocular pressure and aqueous outflow resistance.
-
Keywords of People
-
Badea, Cristian Tudorel,
Professor in Radiology,
Biomedical Engineering
-
Berchuck, Andrew,
James M. Ingram Distinguished Professor of Gynecologic Oncology,
Obstetrics and Gynecology, Gynecologic Oncology
-
Buckley, Anne Frances,
Assistant Professor of Pathology,
Pathology
-
Chen, Jun,
Professor of Medicine,
Duke Cancer Institute
-
Cianciolo, George James,
Associate Professor in Pathology,
Pathology
-
Driehuys, Bastiaan,
Professor of Radiology,
Biomedical Engineering
-
Farsiu, Sina,
Professor in the Department of Biomedical Engineering,
Electrical and Computer Engineering
-
Guan, Ziqiang,
Research Professor in Biochemistry,
Biochemistry
-
Gunn, Michael Dee,
Professor of Medicine,
Immunology
-
Hanks, Brent A.,
Associate Professor of Medicine,
Pharmacology & Cancer Biology
-
Johnson, G. Allan,
Charles E. Putman University Distinguished Professor of Radiology,
Biomedical Engineering
-
Lee, Walter T,
Professor of Head and Neck Surgery and Communication Sciences,
Radiation Oncology
-
McDonnell, Donald Patrick,
Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine,
Duke Innovation & Entrepreneurship
-
McLendon, Roger Edwin,
Professor of Pathology,
Pathology
-
Nicolelis, Miguel Angelo L.,
Duke School of Medicine Professor in Neuroscience,
Psychology and Neuroscience
-
Pitt, Geoffrey Stuart,
Adjunct Professor in the Department of Medicine,
Medicine, Cardiology
-
Preminger, Glenn Michael,
James F. Glenn, M.D. Distinguished Professor of Urology,
Surgery
-
Sampson, John Howard,
Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine,
Immunology
-
Shinohara, Mari L.,
Associate Professor of Immunology,
Immunology
-
Tsalik, Ephraim,
Associate Professor of Medicine,
Molecular Genetics and Microbiology
-
Yan, Hai,
Henry S. Friedman Distinguished Professor of Neuro-Oncology in the School of Medicine,
Pathology