Mice, Inbred CBA

• 

  Subject Areas on Research

  • 3D model of frequency representation in the cochlear nucleus of the CBA/J mouse. 
  • A functional role for circulating mouse L-selectin in regulating leukocyte/endothelial cell interactions in vivo. 
  • A role for the cytoplasmic tail of the beta chain of CD8 in thymic selection. 
  • A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection. 
  • A synthetic random basic copolymer with promiscuous binding to class II major histocompatibility complex molecules inhibits T-cell proliferative responses to major and minor histocompatibility antigens in vitro and confers the capacity to prevent murine graft-versus-host disease in vivo. 
  • Activation of alloreactive CD8+ T cells operates via CD4-dependent and CD4-independent mechanisms and is CD154 blockade sensitive. 
  • Airway epithelial cell expression of interleukin-6 in transgenic mice. Uncoupling of airway inflammation and bronchial hyperreactivity. 
  • Akt activation protects hippocampal neurons from apoptosis by inhibiting transcriptional activity of p53. 
  • Analysis of the role of membrane polarity in polycystic kidney disease of transgenic SBM mice. 
  • Antitumor activity of temozolomide combined with irinotecan is partly independent of O6-methylguanine-DNA methyltransferase and mismatch repair phenotypes in xenograft models. 
  • B lymphocytes differentially influence acute and chronic allograft rejection in mice. 
  • Biochemical correlates of temozolomide sensitivity in pediatric solid tumor xenograft models. 
  • Carcinogenicity of inhaled benzene in CBA mice. 
  • Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy. 
  • Characterization of cytotoxic cells generated from in vitro cultures of murine bone marrow cells. 
  • Cloning of B cells from autoimmune MRL-lpr/lpr and MRL.xid mice. 
  • Combination anti-CD2 and anti-CD3 monoclonal antibodies induce tolerance while altering interleukin-2, interleukin-4, tumor necrosis factor, and transforming growth factor-beta production. 
  • Comparison of topical dry eye medications for the treatment of keratoconjunctivitis sicca in a botulinum toxin B-induced mouse model. 
  • Complementary roles for CD19 and Bruton's tyrosine kinase in B lymphocyte signal transduction. 
  • Decreased cochlear DNA receptor staining in MRL.MpJ-Fas(lpr) autoimmune mice with hearing loss. 
  • Developmental and transformation-sensitive expression of the Sparc gene on mouse chromosome 11. 
  • Developmental expression of tissue inhibitor of metalloproteinase (TIMP) RNA. 
  • Disruption of intrathymic CD4-Ia interactions on immature CD4+CD8+ thymocytes results in diminished TCR expression on mature CD8+ T cell progeny. 
  • Down-regulation of the orphan nuclear receptor ROR gamma t is essential for T lymphocyte maturation. 
  • Effect of exposure to light-at-night on life span and spontaneous carcinogenesis in female CBA mice. 
  • Effect of synthetic thymic and pineal peptides on biomarkers of ageing, survival and spontaneous tumour incidence in female CBA mice. 
  • Effect of virus infection on the inflammatory response. Depression of macrophage accumulation in influenza-infected mice. 
  • Effect os xid on anti-DNA B-cell precursors. 
  • Efficacy of topoisomerase I inhibitors, topotecan and irinotecan, administered at low dose levels in protracted schedules to mice bearing xenografts of human tumors. 
  • Escherichia coli global gene expression in urine from women with urinary tract infection. 
  • Expansion/deletion of mature T cells exposed to endogenous superantigens in vivo. 
  • Expression of a highly conserved anti-DNA idiotype in normal and autoimmune mice. 
  • Extending principles learned in model systems to clinical trials design. 
  • Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci. 
  • Genetic control of peripheral leukocyte response to endotoxin in mice. 
  • High-resolution, noninvasive longitudinal live imaging of immune responses. 
  • Idiotypic cross-reaction between MRL monoclonal autoantibodies with different antigen specificity. 
  • Idiotypic regulation by isologous monoclonal anti-idiotope antibodies. 
  • Immunologic control of the ascites form of murine adenocarcinoma 755. III. Efficacy of serum therapy is controlled by a single genetic locus. 
  • Immunosuppressive and nonimmunosuppressive cyclosporine analogs are toxic to the opportunistic fungal pathogen Cryptococcus neoformans via cyclophilin-dependent inhibition of calcineurin. 
  • In vivo expression of mRNA for the Ca++-binding protein SPARC (osteonectin) revealed by in situ hybridization. 
  • Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis. 
  • Increased ototoxicity in both young and old mice. 
  • Inhibition of T cell costimulation by VCAM-1 prevents murine graft-versus-host disease across minor histocompatibility barriers. 
  • Integrin functions play a key role in the differentiation of thymocytes in vivo. 
  • Mast cell degranulation induced by type 1 fimbriated Escherichia coli in mice. 
  • Melatonin increases both life span and tumor incidence in female CBA mice. 
  • Optimized regimen for expression of heat-inducible Cre in mice. 
  • Plasma membrane transporters of serotonin, dopamine, and norepinephrine mediate serotonin accumulation in atypical locations in the developing brain of monoamine oxidase A knock-outs. 
  • Quantification of mouse macrophage chemotaxis in vitro: role of C5 for the production of chemotactic activity. 
  • Receptor-mediated antigen delivery into macrophages. Complexing antigen to alpha 2-macroglobulin enhances presentation to T cells. 
  • Relation between Irofulven (MGI-114) systemic exposure and tumor response in human solid tumor xenografts. 
  • Relationship between binding affinity, retention and sensitivity of human rhabdomyosarcoma xenografts to Vinca alkaloids. 
  • Role of PLB1 in pulmonary inflammation and cryptococcal eicosanoid production. 
  • Role of protein O-mannosyltransferase Pmt4 in the morphogenesis and virulence of Cryptococcus neoformans. 
  • Serum osteopontin is a biomarker of severe fibrosis and portal hypertension in human and murine schistosomiasis mansoni. 
  • Specificity and idiotypic analysis of a monoclonal anti-Sm antibody with anti-DNA activity. 
  • T cell-mediated elimination of B7.2 transgenic B cells. 
  • The B-cell repertoire for autoantibodies: frequency of precursor cells for anti-DNA antibodies. 
  • The antibody response of normal mice to immunization with single-stranded DNA of various species origin. 
  • The heritability of antinociception: common pharmacogenetic mediation of five neurochemically distinct analgesics. 
  • The induction of tolerance and suppression in autoimmune MRL mice using hapten-modified self. 
  • Variation in DNA and RNA synthetic responses during activation of lymphocytes from inbred strains of mice. 
  • Viral infection abrogates CD8(+) T-cell deletion induced by costimulation blockade. 
  • [Interstrain differences in extrapolation capacity and exploration of a cruciform maze correlate with various indices of monoamine metabolism in the brain]. 
• 

  Keywords of People

  • Yang, Yiping, Professor of Medicine, Immunology