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Subject Areas on Research
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3D model of frequency representation in the cochlear nucleus of the CBA/J mouse.
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A fluorogenic C. neoformans reporter strain with a robust expression of m-cherry expressed from a safe haven site in the genome.
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A functional role for circulating mouse L-selectin in regulating leukocyte/endothelial cell interactions in vivo.
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A role for the cytoplasmic tail of the beta chain of CD8 in thymic selection.
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A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection.
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A synthetic random basic copolymer with promiscuous binding to class II major histocompatibility complex molecules inhibits T-cell proliferative responses to major and minor histocompatibility antigens in vitro and confers the capacity to prevent murine graft-versus-host disease in vivo.
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Akt activation protects hippocampal neurons from apoptosis by inhibiting transcriptional activity of p53.
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Analysis of the role of membrane polarity in polycystic kidney disease of transgenic SBM mice.
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Antitumor activity of temozolomide combined with irinotecan is partly independent of O6-methylguanine-DNA methyltransferase and mismatch repair phenotypes in xenograft models.
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B lymphocytes differentially influence acute and chronic allograft rejection in mice.
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Biochemical correlates of temozolomide sensitivity in pediatric solid tumor xenograft models.
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Carcinogenicity of inhaled benzene in CBA mice.
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Cartilage-binding antibodies induce pain through immune complex-mediated activation of neurons.
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Characterization of cytotoxic cells generated from in vitro cultures of murine bone marrow cells.
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Chitosan Biosynthesis and Virulence in the Human Fungal Pathogen Cryptococcus gattii.
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Cloning of B cells from autoimmune MRL-lpr/lpr and MRL.xid mice.
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Combination anti-CD2 and anti-CD3 monoclonal antibodies induce tolerance while altering interleukin-2, interleukin-4, tumor necrosis factor, and transforming growth factor-beta production.
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Complementary roles for CD19 and Bruton's tyrosine kinase in B lymphocyte signal transduction.
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Conditions for an in vitro culture of murine mixed hematopoietic colonies and their putative cellular origin.
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Cryptococcus neoformans Cda1 and Its Chitin Deacetylase Activity Are Required for Fungal Pathogenesis.
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Decreased cochlear DNA receptor staining in MRL.MpJ-Fas(lpr) autoimmune mice with hearing loss.
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Developmental and transformation-sensitive expression of the Sparc gene on mouse chromosome 11.
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Developmental expression of tissue inhibitor of metalloproteinase (TIMP) RNA.
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Disruption of intrathymic CD4-Ia interactions on immature CD4+CD8+ thymocytes results in diminished TCR expression on mature CD8+ T cell progeny.
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Down-regulation of the orphan nuclear receptor ROR gamma t is essential for T lymphocyte maturation.
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Effect of exposure to light-at-night on life span and spontaneous carcinogenesis in female CBA mice.
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Effect of synthetic thymic and pineal peptides on biomarkers of ageing, survival and spontaneous tumour incidence in female CBA mice.
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Effect of virus infection on the inflammatory response. Depression of macrophage accumulation in influenza-infected mice.
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Effect os xid on anti-DNA B-cell precursors.
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Effects of CoA-independent transacylase inhibitors on the production of lipid inflammatory mediators.
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Efficacy of topoisomerase I inhibitors, topotecan and irinotecan, administered at low dose levels in protracted schedules to mice bearing xenografts of human tumors.
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Escherichia coli global gene expression in urine from women with urinary tract infection.
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Expression of a highly conserved anti-DNA idiotype in normal and autoimmune mice.
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Extending principles learned in model systems to clinical trials design.
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Function of the thioredoxin proteins in Cryptococcus neoformans during stress or virulence and regulation by putative transcriptional modulators.
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Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci.
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Genetic control of peripheral leukocyte response to endotoxin in mice.
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Global Motion Processing by Populations of Direction-Selective Retinal Ganglion Cells.
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High-resolution, noninvasive longitudinal live imaging of immune responses.
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Idiotypic cross-reaction between MRL monoclonal autoantibodies with different antigen specificity.
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Idiotypic regulation by isologous monoclonal anti-idiotope antibodies.
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Immunologic control of the ascites form of murine adenocarcinoma 755. III. Efficacy of serum therapy is controlled by a single genetic locus.
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Immunosuppressive and nonimmunosuppressive cyclosporine analogs are toxic to the opportunistic fungal pathogen Cryptococcus neoformans via cyclophilin-dependent inhibition of calcineurin.
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In vivo expression of mRNA for the Ca++-binding protein SPARC (osteonectin) revealed by in situ hybridization.
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Increased ototoxicity in both young and old mice.
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Inhibition of T cell costimulation by VCAM-1 prevents murine graft-versus-host disease across minor histocompatibility barriers.
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Integrin functions play a key role in the differentiation of thymocytes in vivo.
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Involvement of multiple factors in the clonal deletion of self-reactive T cells.
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Mast cell degranulation induced by type 1 fimbriated Escherichia coli in mice.
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Melatonin increases both life span and tumor incidence in female CBA mice.
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Optimized regimen for expression of heat-inducible Cre in mice.
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Posttranslational, translational, and transcriptional responses to nitric oxide stress in Cryptococcus neoformans: implications for virulence.
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Quantification of mouse macrophage chemotaxis in vitro: role of C5 for the production of chemotactic activity.
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Receptor-mediated antigen delivery into macrophages. Complexing antigen to alpha 2-macroglobulin enhances presentation to T cells.
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Relation between Irofulven (MGI-114) systemic exposure and tumor response in human solid tumor xenografts.
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Relationship between binding affinity, retention and sensitivity of human rhabdomyosarcoma xenografts to Vinca alkaloids.
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Role of PLB1 in pulmonary inflammation and cryptococcal eicosanoid production.
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Role of protein O-mannosyltransferase Pmt4 in the morphogenesis and virulence of Cryptococcus neoformans.
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Serum osteopontin is a biomarker of severe fibrosis and portal hypertension in human and murine schistosomiasis mansoni.
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Specificity and idiotypic analysis of a monoclonal anti-Sm antibody with anti-DNA activity.
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Sulphiredoxin plays peroxiredoxin-dependent and -independent roles via the HOG signalling pathway in Cryptococcus neoformans and contributes to fungal virulence.
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T cell-mediated elimination of B7.2 transgenic B cells.
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The B-cell repertoire for autoantibodies: frequency of precursor cells for anti-DNA antibodies.
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The antibody response of normal mice to immunization with single-stranded DNA of various species origin.
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The heritability of antinociception: common pharmacogenetic mediation of five neurochemically distinct analgesics.
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The induction of tolerance and suppression in autoimmune MRL mice using hapten-modified self.
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Thiol peroxidase is critical for virulence and resistance to nitric oxide and peroxide in the fungal pathogen, Cryptococcus neoformans.
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Transcriptional profiling of the Sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursors.
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Variation in DNA and RNA synthetic responses during activation of lymphocytes from inbred strains of mice.
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Viral infection abrogates CD8(+) T-cell deletion induced by costimulation blockade.