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Subject Areas on Research
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A MAP kinase cascade composed of cell type specific and non-specific elements controls mating and differentiation of the fungal pathogen Cryptococcus neoformans.
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A functional role for circulating mouse L-selectin in regulating leukocyte/endothelial cell interactions in vivo.
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A major role for the EP4 receptor in regulation of renin.
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A mechanism-based antioxidant approach for the reduction of skin carcinogenesis.
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A prior feature SVM-MRF based method for mouse brain segmentation.
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A role for fractalkine and its receptor (CX3CR1) in cardiac allograft rejection.
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A unique pathway for the plasma elimination of alpha 2-antiplasmin-protease complexes in mice.
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Absence of donor MHC antigen expression ameliorates chronic kidney allograft rejection.
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Acceleration of mammary neoplasia in transforming growth factor alpha transgenic mice by 7,12-dimethylbenzanthracene.
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Age-related changes in eye morphology and aqueous humor dynamics in DBA/2J mice using contrast-enhanced ocular MRI.
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Allergen-induced airway disease is mouse strain dependent.
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Altered intragraft immune responses and improved renal function in MHC class II-deficient mouse kidney allografts.
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An N-ethyl-N-nitrosourea mutagenesis recessive screen identifies two candidate regions for murine cardiomyopathy that map to chromosomes 1 and 15.
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Anti-laminin reactivity and glomerular immune deposition by in vitro recombinant antibodies.
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Antineoplastic activity of boron-containing thymidine nucleosides in Tmolt3 leukemic cells.
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Astrocyte cytolysis by MHC class II-specific mouse T cell clones.
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Augmentation of syngeneic tumor-specific immunity by semiallogeneic cell hybrids.
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B cell depletion delays collagen-induced arthritis in mice: arthritis induction requires synergy between humoral and cell-mediated immunity.
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CD11c(+)B220(+)Gr-1(+) cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells.
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Calcineurin controls growth, morphology, and pathogenicity in Aspergillus fumigatus.
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Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformans.
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Cardiac Troponin I-Interacting Kinase Affects Cardiomyocyte S-Phase Activity but Not Cardiomyocyte Proliferation.
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Cardiovascular phenotyping of the mouse heart using a 4D radial acquisition and liposomal Gd-DTPA-BMA.
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Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican.
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Characterization of cytotoxic cells generated from in vitro cultures of murine bone marrow cells.
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Chemical structure of carbamoylating groups and their relationship to bone marrow toxicity and antiglioma activity of bifunctionally alkylating and carbamoylating nitrosoureas.
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Coagulation defects and altered hemodynamic responses in mice lacking receptors for thromboxane A2.
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Comparison of tumor and normal tissue oxygen tension measurements using OxyLite or microelectrodes in rodents.
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Costimulation of adenylyl cyclase and phospholipase C by a mutant alpha 1B-adrenergic receptor transgene promotes malignant transformation of thyroid follicular cells.
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Cross-reacting antigens on L5178Y cells which serve as targets for cytotoxic T-lymphocyte lysis during establishment of the tumor dormant state.
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Cyclic AMP-dependent protein kinase catalytic subunits have divergent roles in virulence factor production in two varieties of the fungal pathogen Cryptococcus neoformans.
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Decreased Th17 and antigen-specific humoral responses in CX₃ CR1-deficient mice in the collagen-induced arthritis model.
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Deficiency of 5-lipoxygenase accelerates renal allograft rejection in mice.
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Differential seizure sensitivities to picrotoxinin in two inbred strains of mice (DBA/2J and BALB/c ByJ): parallel changes in GABA receptor-mediated chloride flux and receptor binding.
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Dissection of a quantitative trait locus for PR interval duration identifies Tnni3k as a novel modulator of cardiac conduction.
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Distinct nuclear proteins competing for an overlapping sequence of cyclic adenosine monophosphate and negative regulatory elements regulate tissue-specific mouse renin gene expression.
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Downregulation of T cell receptor expression by CD8(+) lymphocytes in kidney allografts.
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Effect of Steel factor and leukaemia inhibitory factor on murine primordial germ cells in culture.
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Effect os xid on anti-DNA B-cell precursors.
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Enhanced Th17-cell responses render CCR2-deficient mice more susceptible for autoimmune arthritis.
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Enhancer analysis of the mouse HNF-3 beta gene: regulatory elements for node/notochord and floor plate are independent and consist of multiple sub-elements.
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Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis.
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Expression of a highly conserved anti-DNA idiotype in normal and autoimmune mice.
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FGF9 promotes survival of germ cells in the fetal testis.
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Gene duplications at the chemokine locus on mouse chromosome 4: multiple strain-specific haplotypes and the deletion of secondary lymphoid-organ chemokine and EBI-1 ligand chemokine genes in the plt mutation.
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Genetic dissection of the mouse brain using high-field magnetic resonance microscopy.
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Genetic factors determine the contribution of leukotrienes to acute inflammatory responses.
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Genetic modifier loci affecting survival and cardiac function in murine dilated cardiomyopathy.
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Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma.
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Graft hyporeactivity induced by donor-derived dendritic cell progenitors.
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Graft hyporeactivity induced by immature donor-derived dendritic cells.
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H2-DMalpha(-/-) mice show the importance of major histocompatibility complex-bound peptide in cardiac allograft rejection.
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HSV-1 retinitis and delayed hypersensitivity in DBA/2 and C57BL/6 mice.
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Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl.
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Heart size-independent analysis of myocardial function in murine pressure overload hypertrophy.
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Idiotypic analysis of a monoclonal anti-Sm antibody. II. Strain distribution of a common idiotypic determinant and its relationship to anti-Sm expression.
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Idiotypic cross-reaction between MRL monoclonal autoantibodies with different antigen specificity.
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Immunologic control of the ascites form of murine adenocarcinoma 755. III. Efficacy of serum therapy is controlled by a single genetic locus.
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Immunotherapy of murine leukemia. II. Effect of passive serum therapy on Friend murine leukemia virus-induced hematologic and coagulation parameters.
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Impact of mating type, serotype, and ploidy on the virulence of Cryptococcus neoformans.
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In vitro and in vivo investigations for the development of cytostatic methylhydrazones.
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In vivo identification of a negative regulatory element in the mouse renin gene using direct gene transfer.
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In vivo lysis of L5178Y cells in the establishment of the tumor-dormant state in DBA/2 mice.
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Independently derived murine glomerular immune deposit-forming anti-DNA antibodies are encoded by near-identical VH gene sequences.
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Induction of cytochrome P-450 isozymes by hexachlorobenzene in rats and aromatic hydrocarbon (Ah)-responsive mice.
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Influence of genetic background on albuminuria and kidney injury in Ins2(+/C96Y) (Akita) mice.
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Inhibition of DNA synthesis and enhancement of the uptake and action of methotrexate by low-power-density microwave radiation in L1210 leukemia cells.
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Interaction between genetic background and the mating-type locus in Cryptococcus neoformans virulence potential.
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Interferon production in mixed cultures of murine leukocytes and syngeneic L1210 leukemia cells.
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Ir genes of different high responder haplotypes for staphylococcal nuclease are not allelic.
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Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide.
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LXRalpha functions as a cAMP-responsive transcriptional regulator of gene expression.
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Localization of the mouse gene for secreted phosphoprotein 1 (Spp-1) (2ar, osteopontin, bone sialoprotein 1, 44-kDa bone phosphoprotein, tumor-secreted phosphoprotein) to chromosome 5, closely linked to Ric (Rickettsia resistance).
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Low-dimensional learned feature spaces quantify individual and group differences in vocal repertoires.
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Lung development and repair: contribution of the ciliated lineage.
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MicroRNA-17-92 controls T-cell responses in graft-versus-host disease and leukemia relapse in mice.
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Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene.
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Microwave treatment of intracerebral L1210 leukemia: schedule-dependent partial reversal of the effects of methotrexate.
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Molecular analysis of spontaneous nephrotropic anti-laminin antibodies in an autoimmune MRL-lpr/lpr mouse.
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Monocyte adhesion in patients with bone marrow fibrosis is required for the production of fibrogenic cytokines. Potential role for interleukin-1 and TGF-beta.
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Mouse microcytic anaemia caused by a defect in the gene encoding the globin enhancer-binding protein NF-E2.
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Mouse models of retinal ganglion cell death and glaucoma.
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Multimodal optical and Gd-based nanoparticles for imaging in inflammatory arthritis.
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Multivalent 4-1BB binding aptamers costimulate CD8+ T cells and inhibit tumor growth in mice.
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Natural anti-carbohydrate IgM in mice: dependence on age and strain.
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Operational immune tolerance towards transplanted allogeneic pancreatic islets in mice and a non-human primate.
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Overexpression of TNNI3K, a cardiac-specific MAPKKK, promotes cardiac dysfunction.
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Overexpression of androgen-binding protein/sex hormone-binding globulin in male transgenic mice: tissue distribution and phenotypic disorders.
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Pancreatic expression and secretion of human islet amyloid polypeptide in a transgenic mouse.
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Pathogenicity of Saccharomyces cerevisiae in complement factor five-deficient mice.
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Patterns of expression of murine Vgr-1 and BMP-2a RNA suggest that transforming growth factor-beta-like genes coordinately regulate aspects of embryonic development.
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Permanent survival of fully MHC-mismatched islet allografts by targeting a single chemokine receptor pathway.
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Pharmacological inhibition of TAK1, with the selective inhibitor takinib, alleviates clinical manifestation of arthritis in CIA mice.
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Plasma thrombopoietic activity in humans with normal and abnormal platelet counts.
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Plasminogen alleles influence susceptibility to invasive aspergillosis.
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Progesterone inhibits glucocorticoid-induced murine thymocyte apoptosis.
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QTL mapping in a mouse model of cardiomyopathy reveals an ancestral modifier allele affecting heart function and survival.
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RPGRIP1 is essential for normal rod photoreceptor outer segment elaboration and morphogenesis.
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Receptors for prostaglandin E(2) that regulate cellular immune responses in the mouse.
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Rejection of kidney allografts by MHC class I-deficient mice.
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Restriction of tumor growth in mice by sodium-deficient diet.
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Retina- and ventral forebrain-specific Cre recombinase activity in transgenic mice.
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Rho kinase promotes alloimmune responses by regulating the proliferation and structure of T cells.
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Role of microsomal prostaglandin E synthase 1 in the kidney.
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S100A9 is not essential for disease expression in an acute (K/BxN) or chronic (CIA) model of inflammatory arthritis.
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Specificity and idiotypic analysis of a monoclonal anti-Sm antibody with anti-DNA activity.
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Spink2 modulates apoptotic susceptibility and is a candidate gene in the Rgcs1 QTL that affects retinal ganglion cell death after optic nerve damage.
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Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility.
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Ten nucleotide differences, five of which cause amino acid changes, are associated with the Ah receptor locus polymorphism of C57BL/6 and DBA/2 mice.
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The Cryptococcus neoformans MAP kinase Mpk1 regulates cell integrity in response to antifungal drugs and loss of calcineurin function.
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The alpha-specific cell identity factor Sxi1alpha is not required for virulence of Cryptococcus neoformans.
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The genetics of innate immunity in the lung.
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The heritability of antinociception: common pharmacogenetic mediation of five neurochemically distinct analgesics.
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The impact of microsomal prostaglandin e synthase 1 on blood pressure is determined by genetic background.
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The influence of variable-region somatic mutations on the specificity and pathogenicity of murine monoclonal anti-DNA antibodies.
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The mouse Cd83 gene: structure, domain organization, and chromosome localization.
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The prostaglandin E2 EP1 receptor mediates pain perception and regulates blood pressure.
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The prostaglandin receptor EP4 triggers remodelling of the cardiovascular system at birth.
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The tumor dormant state. Quantitation of L5178Y cells and host immune responses during the establishment and course of dormancy in syngeneic DBA/2 mice.
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The winged helix gene, Mf3, is required for normal development of the diencephalon and midbrain, postnatal growth and the milk-ejection reflex.
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Therapeutic B cell depletion impairs adaptive and autoreactive CD4+ T cell activation in mice.
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Tissue expression studies on the mouse acyl-CoA: cholesterol acyltransferase gene (Acact): findings supporting the existence of multiple cholesterol esterification enzymes in mice.
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Tissue specificity of renin promoter activity and regulation in mice.
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Tissue-specific expression of the rat androgen-binding protein/sex hormone-binding globulin gene in transgenic mice.
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Transgenic mice overproducing islet amyloid polypeptide have increased insulin storage and secretion in vitro.
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Unexpected anti-alpha GalNAc antibodies in alpha-galactosyl transferase-deficient mice: complex relationship between genotype and the natural antibody repertoire.
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Use of etoposide in combination with cyclosporin for purging multidrug-resistant leukemic cells from bone marrow in a mouse model.
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Variation in DNA and RNA synthetic responses during activation of lymphocytes from inbred strains of mice.
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Keywords of People
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Gunn, Michael Dee,
Professor of Medicine,
Immunology
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Hogan, Brigid L. M.,
Research Professor of Cell Biology,
Cell Biology
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Pitt, Geoffrey Stuart,
Adjunct Professor in the Department of Medicine,
Medicine, Cardiology