Mice, Inbred Strains

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  Subject Areas on Research

  • 4.5 kb of the rat tyrosine hydroxylase 5' flanking sequence directs tissue specific expression during development and contains consensus sites for multiple transcription factors. 
  • A Ras1-Cdc24 signal transduction pathway mediates thermotolerance in the fungal pathogen Cryptococcus neoformans. 
  • A candidate taste receptor gene near a sweet taste locus. 
  • A genetic approach for studying the physiology of the type 1A (AT1A) angiotensin receptor. 
  • A locus mapping to mouse chromosome 7 determines infarct volume in a mouse model of ischemic stroke. 
  • A major role for the EP4 receptor in regulation of renin. 
  • A neutralizing epitope of the superantigen SEA has agonist activity on T cells. 
  • A novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism. 
  • A novel modifier gene for plasma von Willebrand factor level maps to distal mouse chromosome 11. 
  • A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program. 
  • A role for angiotensin II type 1 receptors on bone marrow-derived cells in the pathogenesis of angiotensin II-dependent hypertension. 
  • A single genetic locus determines the efficacy of serum therapy against murine adenocarcinoma 755a. 
  • A work-performing heart preparation for myocardial performance analysis in murine hearts. 
  • AT2 receptor and vascular smooth muscle cell differentiation in vascular development. 
  • Absence of posttraumatic arthritis following intraarticular fracture in the MRL/MpJ mouse. 
  • Abundant androgen regulated mRNAs in mouse submandibular gland: cell-free translation of renin precursor mRNA. 
  • Accelerated induction of experimental allergic encephalomyelitis in PL/J mice by a non-V beta 8-specific superantigen. 
  • Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1R132H-Induced Metabolic Liabilities. 
  • Age-dependent alterations of peritoneal exudate macrophages in autoimmune-prone and autoimmune-resistant mouse strains. 
  • Airway inflammation and responsiveness in prostaglandin H synthase-deficient mice exposed to bacterial lipopolysaccharide. 
  • Alloimmune lung injury induced by local innate immune activation through inhaled lipopolysaccharide. 
  • Alopecia in IL-10-deficient mouse pups is c-kit-dependent and can be triggered by iron deficiency. 
  • Alterations in inorganic phosphate in mouse hindlimb muscles during limb disuse. 
  • Altered intragraft immune responses and improved renal function in MHC class II-deficient mouse kidney allografts. 
  • Altered lymphocyte responses and cytokine production in mice deficient in the X-linked lymphoproliferative disease gene SH2D1A/DSHP/SAP. 
  • Altering and assessing persistence of genetically modified E. coli MG1655 in the large bowel. 
  • An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria. 
  • An anxiety-like phenotype in mice selectively bred for aggression. 
  • An endogenous TNF-alpha antagonist induced by splice-switching oligonucleotides reduces inflammation in hepatitis and arthritis mouse models. 
  • An imaging-based approach to identify ligands for olfactory receptors. 
  • An olfactory sensory map develops in the absence of normal projection neurons or GABAergic interneurons. 
  • Angiogenic growth factors in the pathophysiology of a murine model of acute lung injury. 
  • Angiotensin-(1-7) Attenuates Skeletal Muscle Fibrosis and Stiffening in a Mouse Model of Extremity Sarcoma Radiation Therapy. 
  • Animal models provide insight into psychosomatic factors in diabetes. 
  • Anti-DNA antibodies form immune deposits at distinct glomerular and vascular sites. 
  • Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation. 
  • Anti-La antibody production by MRL-1pr/1pr mice. Analysis of fine specificity. 
  • Anti-inflammatory and anti-osteoporotic activities of base-boronated nucleosides and phosphate-boronated nucleotides in rodents. 
  • Anti-inflammatory effects of inhibiting the amine oxidase activity of semicarbazide-sensitive amine oxidase. 
  • Anti-mouse mesangial cell serum induces acute glomerulonephropathy in mice. 
  • Antineoplastic activity of a series of boron analogues of alpha-amino acids. 
  • Antinuclear antibodies and nuclear antigens in NZB myeloma ascitic fluids. 
  • Basal epithelial stem cells are efficient targets for prostate cancer initiation. 
  • Biosynthesis of renin: multiplicity of active and intermediate forms. 
  • Body weight is not always a good predictor of longevity in mice. 
  • Bombesin and [Leu8]phyllolitorin promote fetal mouse lung branching morphogenesis via a receptor-mediated mechanism. 
  • Bombesin increases fetal lung growth and maturation in utero and in organ culture. 
  • Brain tumors in man and animals: report of a workshop. 
  • CD44--a molecule involved in leukocyte adherence and T-cell activation. 
  • Calcitonin gene-related peptide (CGRP) in the developing mouse limb. 
  • Carcinogenicity and toxicity of inhaled nitrobenzene in B6C3F1 mice and F344 and CD rats. 
  • Cardiac-specific LIM protein FHL2 modifies the hypertrophic response to beta-adrenergic stimulation. 
  • Cataract in mice congenitally infected with Toxoplasma gondii. 
  • Catecholamine synthesis is mediated by tyrosinase in the absence of tyrosine hydroxylase. 
  • Catecholaminergic cell lines from the brain and adrenal glands of tyrosine hydroxylase-SV40 T antigen transgenic mice. 
  • Cell-autonomous activation of the PI3-kinase pathway initiates endometrial cancer from adult uterine epithelium. 
  • Cellular requirements for anti-DNA production induced in mice by immunization with bacterial DNA. 
  • Characteristics of Vibration that Alter Cardiovascular Parameters in Mice. 
  • Characterization and expression of the complementary DNA encoding rat histidine decarboxylase. 
  • Characterization and idiotypic analysis of an anti-RNP monoclonal antibody. 
  • Characterization of a novel human corneal endothelial antigen. 
  • Characterization of a spontaneous murine astrocytoma and abrogation of its tumorigenicity by cytokine secretion. 
  • Characterization of glomerular thromboxane receptors in murine lupus nephritis. 
  • Characterization of monoclonal antibodies with specificity for DNA and the synthetic polypeptide antigen (T,G)-A-L. 
  • Characterization of the effects of endotoxin on macrophage tumor cell killing. 
  • Characterization of the insulinotropic potency of polyunsaturated fatty acids. 
  • Chemical denervation with botulinum neurotoxin a improves the surgical manipulation of the muscle-tendon unit: an experimental study in an animal model. 
  • Chloroform inhalation exposure conditions necessary to initiate liver toxicity in female B6C3F1 mice. 
  • Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci. 
  • Ciliary neurotrophic factor receptor alpha mRNA in NB41A3 neuroblastoma cells: regulation by cAMP. 
  • Clonal deletion and clonal anergy in the thymus induced by cellular elements with different radiation sensitivities. 
  • Cloning genes that encode inducible forms of P-450. 
  • Cloning of mitogen- and antigen-reactive B lymphocytes on filter paper disks: phenotypic and genotypic analysis of B cell colonies. 
  • Co-expression of vimentin and cytokeratins in parietal endoderm cells of early mouse embryo. 
  • Comparison of in vitro and in vivo differentiation of myeloblastic leukemia of the RFM/Un mouse. 
  • Comparison of pleural responses of rats and hamsters to subchronic inhalation of refractory ceramic fibers. 
  • Complement C4 inhibits systemic autoimmunity through a mechanism independent of complement receptors CR1 and CR2. 
  • Comprehensive identification of mRNA isoforms reveals the diversity of neural cell-surface molecules with roles in retinal development and disease. 
  • Computationally guided high-throughput design of self-assembling drug nanoparticles. 
  • Comt1 genotype and expression predicts anxiety and nociceptive sensitivity in inbred strains of mice. 
  • Control of expression of insulin resistance and hyperglycemia by different genetic factors in diabetic C57BL/6J mice. 
  • Cryptococcus neoformans gene involved in mammalian pathogenesis identified by a Caenorhabditis elegans progeny-based approach. 
  • Cyclosporine inhibition of a murine B cell lymphoma. 
  • Cysteine-tailed class I-binding peptides bind to CpG adjuvant and enhance primary CTL responses. 
  • Deficits in reproduction and pro-gonadotropin-releasing hormone processing in male Cpefat mice. 
  • Deletion of Y chromosome sequences located outside the testis determining region can cause XY female sex reversal. 
  • Depletion of polymorphonuclear leukocytes has no effect on preterm delivery in a mouse model of Escherichia coli-induced labor. 
  • Derivation of pluripotential embryonic stem cells from murine primordial germ cells in culture. 
  • Detection of the major glycoproteins of Friend leukemia virus (gp71) and the murine mammary tumor virus (gp52) on the surface of mouse cells. 
  • Diabetic kidney disease in FVB/NJ Akita mice: temporal pattern of kidney injury and urinary nephrin excretion. 
  • Diacylglycerol acyltranferase 1 anti-sense oligonucleotides reduce hepatic fibrosis in mice with nonalcoholic steatohepatitis. 
  • Diacylglycerol kinase ζ limits B cell antigen receptor-dependent activation of ERK signaling to inhibit early antibody responses. 
  • Diazoxide restores beta3-adrenergic receptor function in diet-induced obesity and diabetes. 
  • Differential effects of vascular endothelial growth factor receptor-2 inhibitor ZD6474 on circulating endothelial progenitors and mature circulating endothelial cells: implications for use as a surrogate marker of antiangiogenic activity. 
  • Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo. 
  • Differential glycemic effects of morphine in diabetic and normal mice. 
  • Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice. 
  • Disruption of intrathymic CD4-Ia interactions on immature CD4+CD8+ thymocytes results in diminished TCR expression on mature CD8+ T cell progeny. 
  • Divergent pathways mediate the induction of ANF transgenes in neonatal and hypertrophic ventricular myocardium. 
  • Dose-dependent effect of melatonin on life span and spontaneous tumor incidence in female SHR mice. 
  • E2-induced degradation of uterine insulin receptor substrate-2: requirement for an IGF-I-stimulated, proteasome-dependent pathway. 
  • Effect of anti-CD4 antibody treatment on inflammatory arthritis in MRL-lpr/lpr mice. 
  • Effect of basic fibroblast growth factor on angiogenesis and growth of isografted bone: quantitative in vitro-in vivo analysis in mice. 
  • Effect of delta-sleep inducing peptide-containing preparation Deltaran on biomarkers of aging, life span and spontaneous tumor incidence in female SHR mice. 
  • Effect of fatty acids on insulin release: role of chain length and degree of unsaturation. 
  • Effect of neuronol on lifespan and development of spontaneous tumors in SAMP-1 mice with genetically accelerated aging. 
  • Effects of IL-1 on hematopoietic progenitors after myelosuppressive chemoradiotherapy. 
  • Effects of murine cytomegalovirus infection on the immune response to a tumor allograft. 
  • Effects of the kinase inhibitor sorafenib on heart, muscle, liver and plasma metabolism in vivo using non-targeted metabolomics analysis. 
  • Ehd4 is required to attain normal prepubertal testis size but dispensable for fertility in male mice. 
  • Ejaculatory abnormalities in mice with targeted disruption of the gene for heme oxygenase-2. 
  • Embryonic germ cell lines and their derivation from mouse primordial germ cells. 
  • Endogenous production of extracellular adenosine by trabecular meshwork cells: potential role in outflow regulation. 
  • Enhanced growth of small bowel in transgenic mice overexpressing bovine growth hormone. 
  • Enhancement of endocrine pancreatic secretions by essential fatty acids. 
  • Enhancement of experimental anaerobic infections by blood, hemoglobin, and hemostatic agents. 
  • Epidermal growth factor replaces estrogen in the stimulation of female genital-tract growth and differentiation. 
  • Essential role of LAT in T cell development. 
  • EuroPhenome: a repository for high-throughput mouse phenotyping data. 
  • Evidence for an immune barrier after in utero hematopoietic-cell transplantation. 
  • Evidence for the existence of renin in the heart. 
  • Evidence for two cellular pathways of renin secretion by the mouse submandibular gland. 
  • Evidence of CNIH3 involvement in opioid dependence. 
  • Evidence that Gsta4 modifies susceptibility to skin tumor development in mice and humans. 
  • Exogenous Hsp70 delays senescence and improves cognitive function in aging mice. 
  • Expression of Mls determinants in mice exhibiting the severe combined immunodeficiency (scid) mutation or X-linked immunodeficiency (xid) defect. 
  • Expression of a murine cytomegalovirus early-late protein in "latently" infected mice. 
  • Expression of transforming growth factor beta 2 RNA during murine embryogenesis. 
  • FXR1 splicing is important for muscle development and biomolecular condensates in muscle cells. 
  • Facilitative glucose transporter Glut1 is actively excluded from rod outer segments. 
  • Flow cytometric detection of lymphocyte proliferation in eyes with immunogenic inflammation. 
  • Gallbladder glycoprotein secretion in mice with hemolytic anemia and pigment gallstones. 
  • Gene duplications at the chemokine locus on mouse chromosome 4: multiple strain-specific haplotypes and the deletion of secondary lymphoid-organ chemokine and EBI-1 ligand chemokine genes in the plt mutation. 
  • Gene expression profiles of RAW264.7 macrophages stimulated with preparations of LPS differing in isolation and purity. 
  • Gene expression profiling reveals progesterone-mediated cell cycle and immunoregulatory roles of Hoxa-10 in the preimplantation uterus. 
  • Gene expression-based classifiers identify Staphylococcus aureus infection in mice and humans. 
  • Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease. 
  • Genetic basis of murine responses to hyperoxia-induced lung injury. 
  • Genetic control of inflammatory arthritis and glomerulonephritis in congenic lpr mice and their F1 hybrids. 
  • Genetic control of the immune response to nuclease. V. Genetic linkage and strain distribution of anti-nuclease idiotypes. 
  • Genetic control of the immune response to staphylococcal nuclease. VII. Role of non-H2-linked genes in the control of the anti-nuclease antibody response. 
  • Genetic control of the immune response to staphylococcal nuclease. VIII. Mapping of genes for antibodies to different antigenic regions of nuclease. 
  • Genetic dissection of the mouse brain using high-field magnetic resonance microscopy. 
  • Genetic variation in Mon1a affects protein trafficking and modifies macrophage iron loading in mice. 
  • Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity. 
  • Genome-wide functional analysis of phosphatases in the pathogenic fungus Cryptococcus neoformans. 
  • Germinal center formation, immunoglobulin class switching, and autoantibody production driven by "non alpha/beta" T cells. 
  • Glutamine Metabolism Regulates Proliferation and Lineage Allocation in Skeletal Stem Cells. 
  • Glycoprotein 96 perpetuates the persistent inflammation of rheumatoid arthritis. 
  • H2-DMalpha(-/-) mice show the importance of major histocompatibility complex-bound peptide in cardiac allograft rejection. 
  • Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4. 
  • Helix-loop-helix transcription factors E12 and E47 are not essential for skeletal or cardiac myogenesis, erythropoiesis, chondrogenesis, or neurogenesis. 
  • Heparin binding EGF is necessary for vasospastic response to endothelin. 
  • High oxygen prevents fetal lethality due to lack of catecholamines. 
  • High-Density Genotypes of Inbred Mouse Strains: Improved Power and Precision of Association Mapping. 
  • High-frequency alloreactive T cells augment effector function of low-frequency CD8+ T-cell responses under CD28/CD154 blockade. 
  • Host genetic variation in susceptibility to Punta Toro virus. 
  • Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits. 
  • Hypertension in CB57BL/6J mouse model of non-insulin-dependent diabetes mellitus. 
  • Hypolipidemic activity of boronated nucleosides and nucleotides in rodents. 
  • Hypolipidemic activity of tetrakis-mu-(trimethylamine-boranecarboxylato)-bis(trimethylamin e- carboxyborane)-dicopper(II) in rodents and its effect on lipid metabolism. 
  • Hypoxia modulates nitric oxide-induced regulation of NMDA receptor currents and neuronal cell death. 
  • ICAM-1 expression in autoimmune encephalitis visualized using magnetic resonance imaging. 
  • Identification of genes contributing to the obese yellow Avy phenotype: caloric restriction, genotype, diet x genotype interactions. 
  • Idiotypic cross-reaction between MRL monoclonal autoantibodies with different antigen specificity. 
  • IgG binding of monoclonal anti-nuclear antibodies from MRL-lpr/lpr mice. 
  • Immunization with the Sm nuclear antigen induces anti-Sm antibodies in normal and MRL mice. 
  • Immunodominant liver-specific expression suppresses transgene-directed immune responses in murine pompe disease. 
  • Immunofluorescent analysis of expression of the RNA tumor virus major glycoprotein, gp71, on the surfaces of normal murine cells. 
  • Immunogenic determinants of a neuropathogenic murine leukemia virus. 
  • Immunologic control of the ascites of murine adenocarcinoma 755. I. Protection with syngeneic immune serum or lymphoid cells. 
  • Immunological consequences of transplanting rat insulinomas. 
  • Impact of genetic background on nephropathy in diabetic mice. 
  • Impaired second phase insulin response of diabetes-prone C57BL/6J mouse islets. 
  • In vitro and in vivo investigations for the development of cytostatic methylhydrazones. 
  • In vitro survival and differentiation of neurons derived from epidermal growth factor-responsive postnatal hippocampal stem cells: inducing effects of brain-derived neurotrophic factor. 
  • In vivo antigenic modification of tumor cells. I. Introduction of murine leukemia virus antigens on non-virus-producing murine sarcomas. 
  • In vivo antigenic modification of tumor cells. II. Distribution of virus in sarcoma-bearing mice. 
  • In vivo antigenic modification of tumor cells. III. Metastatic thymic lymphoma specifically infected by thymotropic retrovirus. 
  • In vivo models for studying mast cell-dependent responses to bacterial infection. 
  • In vivo modulation of macrophage tumoricidal activity: enhanced tumor cell killing by peritoneal macrophages from mice given injections of sodium periodate. 
  • In vivo photoacoustic imaging of transverse blood flow by using Doppler broadening of bandwidth. 
  • Inactivation of murine xenotropic oncornavirus by normal mouse sera is not immunoglobulin-mediated. 
  • Increasing fructose 2,6-bisphosphate overcomes hepatic insulin resistance of type 2 diabetes. 
  • Inducible nitric oxide synthase promotes cytokine expression in cardiac allografts but is not required for efficient rejection. 
  • Induction of cross-reactive anti-dsDNA antibodies in preautoimmune NZB/NZW mice by immunization with bacterial DNA. 
  • Induction of immune-mediated glomerulonephritis in normal mice immunized with bacterial DNA. 
  • Influence of genotype, dose and sex on pruritogen-induced scratching behavior in the mouse. 
  • Influence of nociception and stress-induced antinociception on genetic variation in isoflurane anesthetic potency among mouse strains. 
  • Inhibition of in vitro anti-DNA B-cell responses by cyclosporine. 
  • Inhibition of murine cytotoxic T lymphocyte activity by a synthetic retroviral peptide and abrogation of this activity by IL. 
  • Initial displacement of the intra-articular surface after articular fracture correlates with PTA in C57BL/6 mice but not "superhealer" MRL/MpJ mice. 
  • Initial testing (stage 1) of a monoclonal antibody (SCH 717454) against the IGF-1 receptor by the pediatric preclinical testing program. 
  • Initial testing (stage 1) of the BH3 mimetic ABT-263 by the pediatric preclinical testing program. 
  • Initial testing (stage 1) of the proteasome inhibitor bortezomib by the pediatric preclinical testing program. 
  • Initial testing of VNP40101M (Cloretazine) by the pediatric preclinical testing program. 
  • Initial testing of dasatinib by the pediatric preclinical testing program. 
  • Insulin in aging and cancer: antidiabetic drug Diabenol as geroprotector and anticarcinogen. 
  • Interferon suppresses pinocytosis but stimulates phagocytosis in mouse peritoneal macrophages: related changes in cytoskeletal organization. 
  • Intrinsic and induced regulation of the age-associated onset of spontaneous experimental autoimmune encephalomyelitis. 
  • Introduction of foreign genes into tissues of living mice by DNA-coated microprojectiles. 
  • Investigation of antiestrogenic properties of unleaded gasoline in female mice. 
  • Involvement of multiple factors in the clonal deletion of self-reactive T cells. 
  • Kinetics of release of serotonin from isolated secretory granules. I. Amperometric detection of serotonin from electroporated granules. 
  • Kinetics of release of serotonin from isolated secretory granules. II. Ion exchange determines the diffusivity of serotonin. 
  • Lactobacillus rhamnosus GG improves outcome in experimental pseudomonas aeruginosa pneumonia: potential role of regulatory T cells. 
  • Lactoferrin expression in the mouse reproductive tract during the natural estrous cycle: correlation with circulating estradiol and progesterone. 
  • Left ventricular hypertrophy in ascending aortic stenosis mice: anoikis and the progression to early failure. 
  • Left ventricular volumes and function in the embryonic mouse heart. 
  • Lens fiber cell elongation and differentiation is associated with a robust increase in myosin light chain phosphorylation in the developing mouse. 
  • Linkage of genes for laminin B1 and B2 subunits on chromosome 1 in mouse. 
  • Local production of TGF beta1 inhibits cerebral edema, enhances TNF-alpha induced apoptosis and improves survival in a murine glioma model. 
  • Localization and phosphorylation of Abl-interactor proteins, Abi-1 and Abi-2, in the developing nervous system. 
  • Long- and short-lived murine hematopoietic stem cell clones individually identified with retroviral integration markers. 
  • Long-term pulmonary responses of three laboratory rodent species to subchronic inhalation of pigmentary titanium dioxide particles. 
  • Long-term stability of electroenzymatic glucose sensors implanted in mice. An update. 
  • Loss of atm radiosensitizes multiple p53 null tissues. 
  • Low plasma leptin in response to dietary fat in diabetes- and obesity-prone mice. 
  • Macrophage invasion contributes to degeneration of stria vascularis in Pendred syndrome mouse model. 
  • Macrophage polykaryon formation in vitro by peritoneal cells from mice given injections of sodium periodate. 
  • Maintenance of long-lived plasma cells and serological memory despite mature and memory B cell depletion during CD20 immunotherapy in mice. 
  • Male mice deficient in microsomal epoxide hydrolase are not susceptible to benzene-induced toxicity. 
  • Mechanisms of autoantibody production in autoimmune MRL mice. 
  • Mechanisms of tolerance induced by PG490-88 in a bone marrow transplantation model. 
  • Melanoma-Derived Wnt5a Promotes Local Dendritic-Cell Expression of IDO and Immunotolerance: Opportunities for Pharmacologic Enhancement of Immunotherapy. 
  • Metabolism and distribution of norethynodrel in pregnant and nonpregnant mice. 
  • Metabolism of chloroform by cytochrome P450 2E1 is required for induction of toxicity in the liver, kidney, and nose of male mice. 
  • Metabolomic analysis of insulin resistance across different mouse strains and diets. 
  • Metastatic prostate cancer in a transgenic mouse. 
  • Migration of mesonephric cells into the mammalian gonad depends on Sry. 
  • Mitochondrial toxicity in hearts of CD-1 mice following perinatal exposure to AZT, 3TC, or AZT/3TC in combination. 
  • Mitosis is required for production of murine leukemia virus and structural proteins during de novo infection. 
  • Modulation of renal disease in autoimmune NZB/NZW mice by immunization with bacterial DNA. 
  • Molecular and genetic characterization of a radiation-induced structural rearrangement in mouse chromosome 2 causing mutations at the limb deformity and agouti loci. 
  • Molecular genetic mechanisms of allelic specific regulation of murine Comt expression. 
  • Monoclonal rheumatoid factors from B6-lpr/lpr mice. 
  • Mouse embryonic germ (EG) cell lines: transmission through the germline and differences in the methylation imprint of insulin-like growth factor 2 receptor (Igf2r) gene compared with embryonic stem (ES) cell lines. 
  • Multivalent cross-linking of membrane Ig sensitizes murine B cells to a broader spectrum of CpG-containing oligodeoxynucleotide motifs, including their methylated counterparts, for stimulation of proliferation and Ig secretion. 
  • Murine monoclonal anti-DNA antibodies penetrate cells, bind to nuclei, and induce glomerular proliferation and proteinuria in vivo. 
  • Murine noroviruses comprising a single genogroup exhibit biological diversity despite limited sequence divergence. 
  • Muscle wasting and interleukin-6-induced atrogin-I expression in the cachectic Apc ( Min/+ ) mouse. 
  • Mutant mice and neuroscience: recommendations concerning genetic background. Banbury Conference on genetic background in mice. 
  • Mycophenolate mofetil suppresses autoimmunity and mortality in the female NZB x NZW F1 mouse model of systemic lupus erythematosus. 
  • Myoepithelial Cells of Submucosal Glands Can Function as Reserve Stem Cells to Regenerate Airways after Injury. 
  • NOV (CCN3) regulation in the growth plate and CCN family member expression in cartilage neoplasia. 
  • Neem oil inhibits two-cell embryo development and trophectoderm attachment and proliferation in vitro. 
  • Neonatal W-mutant mice are favorable hosts for tracking development of marked hematopoietic stem cells. 
  • Nephrotoxicity and hepatotoxicity induced by inhaled bromodichloromethane in wild-type and p53-heterozygous mice. 
  • Neural induction and patterning in the mouse in the absence of the node and its derivatives. 
  • Neural plate morphogenesis during mouse neurulation is regulated by antagonism of Bmp signalling. 
  • Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease. 
  • Next-generation computational genetic analysis: multiple complement alleles control survival after Candida albicans infection. 
  • Nitric oxide regulation of myocardial contractility and calcium cycling: independent impact of neuronal and endothelial nitric oxide synthases. 
  • Nitrosylation of blood hemoglobin and renal nonheme proteins in autoimmune MRL-lpr/lpr mice. 
  • Noninvasively induced degeneration of neocortical pyramidal neurons in vivo: selective targeting by laser activation of retrogradely transported photolytic chromophore. 
  • Notch-dependent differentiation of adult airway basal stem cells. 
  • Novel MRI and fluorescent probes responsive to the Factor XIII transglutaminase activity. 
  • One small step for mice, one giant leap for GWAS? 
  • Organogenesis and pattern formation in the mouse: RNA distribution patterns suggest a role for bone morphogenetic protein-2A (BMP-2A). 
  • Overexpression of extracellular superoxide dismutase decreases lung injury after exposure to oil fly ash. 
  • Oxidative stress and inflammation contribute to lung toxicity after a common breast cancer chemotherapy regimen. 
  • PG27, an extract of Tripterygium wilfordii hook f, induces antigen-specific tolerance in bone marrow transplantation in mice. 
  • Paclitaxel-induced neuropathic hypersensitivity in mice: responses in 10 inbred mouse strains. 
  • Pain modality- and sex-specific effects of COMT genetic functional variants. 
  • Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTP. 
  • Peripheral mobilization of recipient bone marrow-derived endothelial progenitor cells enhances pancreatic islet revascularization and engraftment after intraportal transplantation. 
  • Permeability of different experimental brain tumor models to horseradish peroxidase. 
  • Phenylalanine hydroxylase in dilute lethal mice. 
  • Phorbol diester-induced H2O2 production by peritoneal macrophages. Different H2O2 production by macrophages from normal and BCG-infected mice despite comparable phorbol diester receptors. 
  • Phosphodiesterase 5 inhibition ameliorates angiontensin II-induced podocyte dysmotility via the protein kinase G-mediated downregulation of TRPC6 activity. 
  • Physiologic role for enhanced renal thromboxane production in murine lupus nephritis. 
  • Piezo-assisted nuclear transfer affects cloning efficiency and may cause apoptosis. 
  • Plasma FGF23 levels increase rapidly after acute kidney injury. 
  • Postnatal construction of neural circuitry in the mouse olfactory bulb. 
  • Potentiation of diethylstilbestrol-induced alterations in the female mouse reproductive tract by transforming growth factor-alpha transgene expression. 
  • Pparg-P465L mutation worsens hyperglycemia in Ins2-Akita female mice via adipose-specific insulin resistance and storage dysfunction. 
  • Prevention of graft-versus-host disease by a novel immunosuppressant, PG490-88, through inhibition of alloreactive T cell expansion. 
  • Prevention of graft-versus-host disease while preserving graft-versus-leukemia effect after selective depletion of host-reactive T cells by photodynamic cell purging process. 
  • Production and role of cytokines in the CNS of mice with acute viral encephalomyelitis. 
  • Prolonged survival of class II transactivator-deficient cardiac allografts. 
  • Pronounced thrombocytosis in transgenic mice expressing reduced levels of Mpl in platelets and terminally differentiated megakaryocytes. 
  • Properties of multilamellar liposomes containing 99mTcO4-: effect of distearoylphosphatidylcholine to sphingomyelin ratio. 
  • Proteolytic activity and immunogenicity of oral bromelain within the gastrointestinal tract of mice. 
  • Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles. 
  • Qa-2-dependent selection of CD8alpha/alpha T cell receptor alpha/beta(+) cells in murine intestinal intraepithelial lymphocytes. 
  • Quantitative trait locus and computational mapping identifies Kcnj9 (GIRK3) as a candidate gene affecting analgesia from multiple drug classes. 
  • RBP-Jκ-dependent Notch signaling is required for murine articular cartilage and joint maintenance. 
  • Rapamycin suppression of host-versus-graft and graft-versus-host disease in MHC-mismatched rats. 
  • Regulation of E2A gene expression in B-lymphocyte development. 
  • Regulation of IgE synthesis: introduction. 
  • Regulation of flt-1 expression during mouse embryogenesis suggests a role in the establishment of vascular endothelium. 
  • Regulation of local and metastatic host-mediated anti-tumour mechanisms by L-selectin and intercellular adhesion molecule-1. 
  • Regulation of sodium balance and blood pressure by the AT(1A) receptor for angiotensin II. 
  • Regulation of the anti-Sm autoantibody response in systemic lupus erythematosus mice by monoclonal anti-Sm antibodies. 
  • Regulatory B cells (B10 cells) and regulatory T cells have independent roles in controlling experimental autoimmune encephalomyelitis initiation and late-phase immunopathogenesis. 
  • Regulatory genes linked to the albino locus in the mouse confer competence for inducible expression on the structural gene encoding serine dehydratase. 
  • Renal tubular cell expression of MHC class II (I-Eb) is insufficient to initiate immune injury in a transgenic kidney transplant model. 
  • Reprogramming metabolic pathways in vivo with CRISPR/Cas9 genome editing to treat hereditary tyrosinaemia. 
  • Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions. 
  • Retinoic acid induction and regional differentiation prefigure olfactory pathway formation in the mammalian forebrain. 
  • Retinoid-related orphan receptor gamma (RORgamma) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis. 
  • Revisiting lessons from the C57BL/6J mouse. 
  • Role for hedgehog pathway in regulating growth and function of invariant NKT cells. 
  • Rous sarcoma virus-induced tumours in mice. II. Contribution of H-2 and non-H-2 alloantigen barriers to tumour immunogenicity in vivo. 
  • Secretoglobins SCGB3A1 and SCGB3A2 define secretory cell subsets in mouse and human airways. 
  • Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38alpha MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes. 
  • Sequence elements required for transcriptional activity of the human myoglobin promoter in intact myocardium. 
  • Serine/threonine phosphorylation regulates HNF-4alpha-dependent redox-mediated iNOS expression in hepatocytes. 
  • Sertoli cell ablation and replacement of the spermatogonial niche in mouse. 
  • Single cell analysis reveals distinct immune landscapes in transplant and primary sarcomas that determine response or resistance to immunotherapy. 
  • Single-cell imaging of T cell immunotherapy responses in vivo. 
  • Species differences in cardiac thyroid hormone receptor isoforms protein abundance. 
  • Specific transforming potential of oncogenes encoding protein-tyrosine kinases. 
  • Specificity analysis of monoclonal anti-DNA antibodies from B6-lpr/lpr mice. 
  • Specificity analysis of monoclonal anti-DNA antibodies. 
  • Spermiogenesis and exchange of basic nuclear proteins are impaired in male germ cells lacking Camk4. 
  • Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA. 
  • Stochastic pairing of heavy-chain and kappa light-chain variable gene families occurs in polyclonally activated B cells. 
  • Structural features of nephritogenic lupus autoantibodies. 
  • Structure of the genes encoding the CD19 antigen of human and mouse B lymphocytes. 
  • Studies on the mechanism and specificity of the effect of the synthetic random copolymer GLAT on graft-versus-host disease. 
  • Successful tumour immunotherapy: possible role of antibodies to anti-inflammatory factors produced by neoplasms. 
  • Suppressor and activator functions mediated by a repeated heptad sequence in the liver fatty acid-binding protein gene (Fabpl). Effects on renal, small intestinal, and colonic epithelial cell gene expression in transgenic mice. 
  • Supraspinal inactivation of mitochondrial superoxide dismutase is a source of peroxynitrite in the development of morphine antinociceptive tolerance. 
  • Synergy between tumor immunotherapy and antiangiogenic therapy. 
  • Systems Genetics Approach Identifies Gene Pathways and Adamts2 as Drivers of Isoproterenol-Induced Cardiac Hypertrophy and Cardiomyopathy in Mice. 
  • Targeted inhibition of beta-adrenergic receptor kinase-1-associated phosphoinositide-3 kinase activity preserves beta-adrenergic receptor signaling and prolongs survival in heart failure induced by calsequestrin overexpression. 
  • Targeting molecular and cellular inhibitory mechanisms for improvement of antitumor memory responses reactivated by tumor cell vaccine. 
  • Temporal and lineage-specific control of T cell receptor alpha/delta gene rearrangement by T cell receptor alpha and delta enhancers. 
  • Tenascin is induced at implantation sites in the mouse uterus and interferes with epithelial cell adhesion. 
  • Terminal bronchioles harbor a unique airway stem cell population that localizes to the bronchoalveolar duct junction. 
  • Testosterone regulates cell proliferation in aggressive fibromatosis (desmoid tumour). 
  • The HMG-CoA reductase inhibitor pravastatin stimulates insulin secretion through organic anion transporter polypeptides. 
  • The IFN pregnancy recognition hormone IFN-tau blocks both development and superantigen reactivation of experimental allergic encephalomyelitis without associated toxicity. 
  • The acute toxicity of drugs acting at cholinoceptive sites and twenty-four hour rhythms in brain acetylcholine. 
  • The androgen-binding protein gene is expressed in CD1 mouse testis. 
  • The anti-La response of a single MRL/Mp-lpr/lpr mouse: specificity for DNA and VH gene usage. 
  • The binding of fucose-containing glycoproteins by hepatic lectins. Re-examination of the clearance from blood and the binding to membrane receptors and pure lectins. 
  • The clearance of a monoclonal anti-DNA antibody following administration of DNA in normal and autoimmune mice. 
  • The clearance of human fibrinogen fragments X and Y in mice: a process mediated by the fragment D receptor. 
  • The fine specificity of anti-La antibodies induced in mice by immunization with recombinant human La autoantigen. 
  • The immune response to staphylococcal nuclease: a probe of cellular and humoral antigen-specific receptors. 
  • The induction of tolerance and suppression in autoimmune MRL mice using hapten-modified self. 
  • The influence of Yaa on anti-DNA responses of B6-lpr mice. 
  • The influence of the lpr gene on B cell activation: differential antibody expression in lpr congenic mouse strains. 
  • The production and characterization of murine monoclonal antibodies to human Gadd45 raised against a recombinant protein. 
  • The role of CD4-Lck in T-cell receptor antagonism: evidence for negative signaling. 
  • The role of GABAB receptor activation in absence seizures of lethargic (lh/lh) mice. 
  • The role of central glucagon-like peptide-1 in mediating the effects of visceral illness: differential effects in rats and mice. 
  • Therapeutic opportunities to prevent post-traumatic arthritis: Lessons from the natural history of arthritis after articular fracture. 
  • Three-dimensional structure of the developing mouse genital ridge. 
  • Thrombospondins 1 and 2 are necessary for synaptic plasticity and functional recovery after stroke. 
  • Thromboxane augmentation of alloreactive T cell function. 
  • Tnni3k modifies disease progression in murine models of cardiomyopathy. 
  • Transferrin receptor is necessary for development of erythrocytes and the nervous system. 
  • Transgenic expression of pancreatic secretory trypsin inhibitor-I ameliorates secretagogue-induced pancreatitis in mice. 
  • Transgenic indicator mice for studying activated retinoic acid receptors during development. 
  • Transgenic tubular cell expression of class II is insufficient to initiate immune renal injury. 
  • Transient receptor potential vanilloid 4 mediates protease activated receptor 2-induced sensitization of colonic afferent nerves and visceral hyperalgesia. 
  • Tumor cells cotransduced with B7.1 and gamma-IFN induce effective rejection of established parental tumor. 
  • Tumor-dendritic cell fusion as a basis for cancer immunotherapy. 
  • Tumorigenic cell culture lines from a spontaneous VM/Dk murine astrocytoma (SMA). 
  • Two-photon molecular excitation imaging of Ca2+ transients in Langendorff-perfused mouse hearts. 
  • Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages. 
  • Variable sensitivity to noxious heat is mediated by differential expression of the CGRP gene. 
  • Variation in DNA-Damage Responses to an Inhalational Carcinogen (1,3-Butadiene) in Relation to Strain-Specific Differences in Chromatin Accessibility and Gene Transcription Profiles in C57BL/6J and CAST/EiJ Mice. 
  • Vascular control of kidney epithelial transporters. 
  • Velocity differences between L- and P-selectin-dependent neutrophil rolling in venules of mouse cremaster muscle in vivo. 
  • Very-long-chain acyl-coenzyme a dehydrogenase deficiency in mice. 
  • Viral infection-homograft interactions in a murine model. 
  • Vital imaging of glomeruli in the mouse olfactory bulb. 
  • Zinc inhibits turnover of labile mRNAs in intact cells. 
  • c-Kit is essential for alveolar maintenance and protection from emphysema-like disease in mice. 
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  Keywords of People

  • Choi, Steven Sok, Associate Professor of Medicine, Medicine, Gastroenterology
  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Gunn, Michael Dee, Professor of Medicine, Integrative Immunobiology
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • Johnson, G. Allan, Charles E. Putman University Distinguished Professor of Radiology, Biomedical Engineering
  • Kelsoe, Garnett H., James B. Duke Distinguished Professor of Immunology, Integrative Immunobiology
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Biomedical Engineering
  • Tsalik, Ephraim, Adjunct Associate Professor in the Department of Medicine, Medicine, Infectious Diseases