Mice, Mutant Strains

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  Subject Areas on Research

  • A Novel Murine Model of Marfan Syndrome Accelerates Aortopathy and Cardiomyopathy. 
  • A Role for Dystonia-Associated Genes in Spinal GABAergic Interneuron Circuitry. 
  • A cerebellar learning model of vestibulo-ocular reflex adaptation in wild-type and mutant mice. 
  • A guide to analysis of mouse energy metabolism. 
  • A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency. 
  • A mouse model for human osteogenesis imperfecta type VI. 
  • A mouse model of congenital heart disease: cardiac arrhythmias and atrial septal defect caused by haploinsufficiency of the cardiac transcription factor Csx/Nkx2.5. 
  • A mouse model of juvenile hemochromatosis. 
  • A murine model for short-chain acyl-CoA dehydrogenase deficiency. 
  • A mutation in Sec15l1 causes anemia in hemoglobin deficit (hbd) mice. 
  • A mutation in a mitochondrial transmembrane protein is responsible for the pleiotropic hematological and skeletal phenotype of flexed-tail (f/f) mice. 
  • A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency. 
  • A point mutation (D79N) of the alpha2A adrenergic receptor abolishes the antiepileptogenic action of endogenous norepinephrine. 
  • A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses. 
  • A role for the thromboxane receptor in L-NAME hypertension. 
  • A role of the CTCF binding site at enhancer Eα in the dynamic chromatin organization of the Tcra-Tcrd locus. 
  • A tamoxifen inducible knock-in allele for investigation of E2A function. 
  • ARID1A Is Essential for Endometrial Function during Early Pregnancy. 
  • AT2 receptor and vascular smooth muscle cell differentiation in vascular development. 
  • Ablation of dihydroceramide desaturase 1, a therapeutic target for the treatment of metabolic diseases, simultaneously stimulates anabolic and catabolic signaling. 
  • Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule. 
  • Abnormal parathyroid function in the X-linked hypophosphatemic mouse. 
  • Abnormal regulation of renal 25-hydroxyvitamin D-1 alpha-hydroxylase activity in the X-linked hypophosphatemic mouse. 
  • Accelerated Marfan syndrome model recapitulates established signaling pathways. 
  • Activation of toll-like receptor 4 is necessary for trauma hemorrhagic shock-induced gut injury and polymorphonuclear neutrophil priming. 
  • Activity level, apoptosis, and development of cachexia in Apc(Min/+) mice. 
  • Advanced magnetic resonance imaging of cerebral cavernous malformations: part II. Imaging of lesions in murine models. 
  • Airway inflammation and responsiveness in prostaglandin H synthase-deficient mice exposed to bacterial lipopolysaccharide. 
  • Allelic exclusion of the TCR alpha-chain is an active process requiring TCR-mediated signaling and c-Cbl. 
  • Alopecia in IL-10-deficient mouse pups is c-kit-dependent and can be triggered by iron deficiency. 
  • Altered distribution of H60 minor H antigen-specific CD8 T cells and attenuated chronic vasculopathy in minor histocompatibility antigen mismatched heart transplantation in Cxcr3-/- mouse recipients. 
  • Alternative splicing in Acad8 resulting a mitochondrial defect and progressive hepatic steatosis in mice. 
  • An essential role of Bmp4 in the atrioventricular septation of the mouse heart. 
  • An intracellular role for ABCG1-mediated cholesterol transport in the regulated secretory pathway of mouse pancreatic beta cells. 
  • Analysis of gene mutations and clastogenicity following short-term treatment with azathioprine in MutaMouse. 
  • Angiotensin induces the urinary peristaltic machinery during the perinatal period. 
  • Angiotensin type 2 receptor is expressed in murine atherosclerotic lesions and modulates lesion evolution. 
  • Animal model for maturity-onset diabetes of the young generated by disruption of the mouse glucokinase gene. 
  • Animal models of hereditary iron transport disorders. 
  • Ankyrin-B is required for intracellular sorting of structurally diverse Ca2+ homeostasis proteins. 
  • Ankyrin-B metabolic syndrome combines age-dependent adiposity with pancreatic β cell insufficiency. 
  • Anterior pituitary hypoplasia and dwarfism in mice lacking the dopamine transporter. 
  • Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation. 
  • Anti-Sm autoantibodies in MRL mice: analysis of precursor frequency. 
  • Antibody response to a T-dependent antigen requires B cell expression of complement receptors. 
  • Antigen-binding repertoire and Ig H chain gene usage among B cell hybridomas from normal and autoimmune mice. 
  • Apolipoprotein E affects the central nervous system response to injury and the development of cerebral edema. 
  • Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response. 
  • Apolipoprotein J/clusterin induction in myocarditis: A localized response gene to myocardial injury. 
  • Apoptosis: final common pathway of photoreceptor death in rd, rds, and rhodopsin mutant mice. 
  • B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB. 
  • BAX-mediated cell death affects early germ cell loss and incidence of testicular teratomas in Dnd1(Ter/Ter) mice. 
  • BMP antagonism protects Nodal signaling in the gastrula to promote the tissue interactions underlying mammalian forebrain and craniofacial patterning. 
  • BMP signaling in the epiblast is required for proper recruitment of the prospective paraxial mesoderm and development of the somites. 
  • BMP4 is essential for lens induction in the mouse embryo. 
  • BRG1 and BRM SWI/SNF ATPases redundantly maintain cardiomyocyte homeostasis by regulating cardiomyocyte mitophagy and mitochondrial dynamics in vivo. 
  • Beta-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitization. 
  • Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute T helper type 1 immune responses. 
  • Bmp4 is essential for the formation of the vestibular apparatus that detects angular head movements. 
  • Bmp7 regulates germ cell proliferation in mouse fetal gonads. 
  • CD19 amplifies B lymphocyte signal transduction by regulating Src-family protein tyrosine kinase activation. 
  • CD19 regulates B lymphocyte signaling thresholds critical for the development of B-1 lineage cells and autoimmunity. 
  • CD19, a response regulator of B lymphocytes, regulates wound healing through hyaluronan-induced TLR4 signaling. 
  • CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: altered signaling in CD22-deficient mice. 
  • CD22 regulates time course of both B cell division and antibody response. 
  • CD25+CD4+ regulatory T cell migration requires L-selectin expression: L-selectin transcriptional regulation balances constitutive receptor turnover. 
  • CD83 influences cell-surface MHC class II expression on B cells and other antigen-presenting cells. 
  • CDK5 regulates cell adhesion and migration in corneal epithelial cells. 
  • Cardioprotective role of S-nitrosylated hemoglobin from rbc. 
  • Characterization of the mouse transforming growth factor alpha gene: its expression during eyelid development and in waved 1 tissues. 
  • Cholinergic regulatory lymphocytes re-establish neuromodulation of innate immune responses in sepsis. 
  • Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci. 
  • Chromosomal localization of the ankyrinG gene (ANK3/Ank3) to human 10q21 and mouse 10. 
  • Chronic ethanol treatment increases expression of inhibitory G-proteins and reduces adenylylcyclase activity in the central nervous system of two lines of ethanol-sensitive mice. 
  • Clonal contributions of small numbers of retrovirally marked hematopoietic stem cells engrafted in unirradiated neonatal W/Wv mice. 
  • Cloning of B cells from autoimmune MRL-lpr/lpr and MRL.xid mice. 
  • Cloning of murine splenic T lymphocytes and natural killer (NK) cells on filter paper discs: detection of a novel NK/T phenotype. 
  • Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm. 
  • Constitutive Notch signalling promotes CD4 CD8 thymocyte differentiation in the absence of the pre-TCR complex, by mimicking pre-TCR signals. 
  • Contributions of nitric oxide synthase isoforms to pulmonary oxygen toxicity, local vs. mediated effects. 
  • Coreceptor signal strength regulates positive selection but does not determine CD4/CD8 lineage choice in a physiologic in vivo model. 
  • Crosstransplantation of kidneys in normal and Hyp mice. Evidence that the Hyp mouse phenotype is unrelated to an intrinsic renal defect. 
  • Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf. 
  • DMT1 expression is increased in the lungs of hypotransferrinemic mice. 
  • Data and animal management software for large-scale phenotype screening. 
  • Decreased platelet aggregation, increased bleeding time and resistance to thromboembolism in P2Y1-deficient mice. 
  • Defects in mononuclear phagocytic system (MPS) function in autoimmune MRL-lpr/lpr mice. 
  • Deficiencies in pro-thyrotropin-releasing hormone processing and abnormalities in thermoregulation in Cpefat/fat mice. 
  • Delayed wound healing in the absence of intercellular adhesion molecule-1 or L-selectin expression. 
  • Deletion of GαZ protein protects against diet-induced glucose intolerance via expansion of β-cell mass. 
  • Deletion of a splicing enhancer disrupts PLP1/DM20 ratio and myelin stability. 
  • Developmental biology. Another hit for gene targeting. 
  • Developmental biology. The making of the ear. 
  • Diacylglycerol kinase ζ deficiency in a non-CD4(+) T-cell compartment leads to increased peanut hypersensitivity. 
  • Dietary factors alter hepatic innate immune system in mice with nonalcoholic fatty liver disease. 
  • Differential effects of doxycycline, a broad-spectrum matrix metalloproteinase inhibitor, on angiotensin II-induced atherosclerosis and abdominal aortic aneurysms. 
  • Differential requirement for the SAP-Fyn interaction during NK T cell development and function. 
  • Differentiation potential of individual olfactory c-Kit+ progenitors determined via multicolor lineage tracing. 
  • Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice. 
  • Distinct ankyrin isoforms at neuron cell bodies and nodes of Ranvier resolved using erythrocyte ankyrin-deficient mice. 
  • Distinct requirements for extra-embryonic and embryonic bone morphogenetic protein 4 in the formation of the node and primitive streak and coordination of left-right asymmetry in the mouse. 
  • Divergent vascular mechanisms downstream of Sry establish the arterial system in the XY gonad. 
  • Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice. 
  • Dysregulation of hedgehog signalling predisposes to synovial chondromatosis. 
  • E proteins are required to activate germline transcription of the TCR Vbeta8.2 gene. 
  • E2A and IRF-4/Pip promote chromatin modification and transcription of the immunoglobulin kappa locus in pre-B cells. 
  • Effects of the lpr mutation on elimination and inactivation of self-reactive B cells. 
  • Elevated blood pressure and enhanced myocardial contractility in mice with severe IGF-1 deficiency. 
  • Embryonic expression of a haematopoietic growth factor encoded by the Sl locus and the ligand for c-kit. 
  • Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin. 
  • Enhanced allergen-induced airway inflammation in paucity of lymph node T cell (plt) mutant mice. 
  • Enhanced contractility and decreased beta-adrenergic receptor kinase-1 in mice lacking endogenous norepinephrine and epinephrine. 
  • Enhanced production of superoxide anion by microglia from trisomy 16 mice. 
  • Enhanced renal leukotriene production in murine lupus: role of lipoxygenase metabolites. 
  • Enzyme-Responsive Delivery of Multiple Proteins with Spatiotemporal Control 
  • Enzymes that counteract nitrosative stress promote fungal virulence. 
  • Epilepsy genetics: an abundance of riches for biologists. 
  • Evidence for the involvement of the Gli gene family in embryonic mouse lung development. 
  • Evidence that autocrine signaling through Bmpr1a regulates the proliferation, survival and morphogenetic behavior of distal lung epithelial cells. 
  • Expression of a highly conserved anti-DNA idiotype in normal and autoimmune mice. 
  • Expression of full-length and truncated dystrophin mini-genes in transgenic mdx mice. 
  • Expression of high mobility group protein 1 in the sera of patients and mice with systemic lupus erythematosus. 
  • Failure of spermatogenesis in mouse lines deficient in the Na(+)-K(+)-2Cl(-) cotransporter. 
  • Fibroblast growth factor 21 mediates specific glucagon actions. 
  • Formation of precise connections in the olfactory bulb occurs in the absence of odorant-evoked neuronal activity. 
  • Functional alterations of macrophages in autoimmune MRL-lpr/lpr mice. 
  • Gamma delta T cell help of B cells is induced by repeated parasitic infection, in the absence of other T cells. 
  • Gene duplications at the chemokine locus on mouse chromosome 4: multiple strain-specific haplotypes and the deletion of secondary lymphoid-organ chemokine and EBI-1 ligand chemokine genes in the plt mutation. 
  • Gene expression profiling reveals progesterone-mediated cell cycle and immunoregulatory roles of Hoxa-10 in the preimplantation uterus. 
  • Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation. 
  • Generation and characterization of mice lacking gastrin-releasing peptide receptor. 
  • Genes that modify the hemochromatosis phenotype in mice. 
  • Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci. 
  • Genetic control of inflammatory arthritis in congenic lpr mice. 
  • Genetic factors determine the contribution of leukotrienes to acute inflammatory responses. 
  • Genetic networks of liver metabolism revealed by integration of metabolic and transcriptional profiling. 
  • Genetic regulation of pristane-induced oil granuloma responses. 
  • Germline transcription from T-cell receptor Vbeta gene is uncoupled from allelic exclusion. 
  • Gq signaling causes glomerular injury by activating TRPC6. 
  • Haploinsufficiency of the transcription factors FOXC1 and FOXC2 results in aberrant ocular development. 
  • Haptoglobin modifies the hemochromatosis phenotype in mice. 
  • Hedgehog-mediated mesenchymal-epithelial interactions modulate hepatic response to bile duct ligation. 
  • Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice. 
  • Hfe deficiency increases susceptibility to cardiotoxicity and exacerbates changes in iron metabolism induced by doxorubicin. 
  • High oxygen prevents fetal lethality due to lack of catecholamines. 
  • High-fructose corn syrup enhances intestinal tumor growth in mice. 
  • High-resolution magnetic resonance histology of the embryonic and neonatal mouse: a 4D atlas and morphologic database. 
  • Hippocampal long-term potentiation is normal in heme oxygenase-2 mutant mice. 
  • Hyper-Ia antigen expression on B cells from B6-lpr/lpr mice correlates with manifestations of the autoimmune state. 
  • IL-10 induces regulatory T cell apoptosis by up-regulation of the membrane form of TNF-alpha. 
  • IL-4 induces differentiation and expansion of Th2 cytokine-producing eosinophils. 
  • Id3 restricts the developmental potential of gamma delta lineage during thymopoiesis. 
  • Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma. 
  • Identity of a pathway for saccadic suppression. 
  • Idiotypic analysis of a monoclonal anti-Sm antibody. II. Strain distribution of a common idiotypic determinant and its relationship to anti-Sm expression. 
  • IgG antinuclear antibodies with cross-reactive rheumatoid factor activity. 
  • Imaging microstructure with diffusion and susceptibility MR: neuronal density correlation in Disrupted-in-Schizophrenia-1 mutant mice. 
  • Immuno-characterization of the switch of peptide elongation factors eEF1A-1/EF-1alpha and eEF1A-2/S1 in the central nervous system during mouse development. 
  • Immunohistochemical evidence of seizure-induced activation of trkB receptors in the mossy fiber pathway of adult mouse hippocampus. 
  • Impact of toll-like receptor 4 deficiency on the response to uterine ischemia/reperfusion in mice. 
  • Impaired expression and functional activity of the beta 3- and beta 1-adrenergic receptors in adipose tissue of congenitally obese (C57BL/6J ob/ob) mice. 
  • Impaired survival of peripheral T cells, disrupted NK/NKT cell development, and liver failure in mice lacking Gimap5. 
  • In vitro development of inner cell masses isolated from t0/t0 and tW5/tW5 mouse embryos. 
  • Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease. 
  • Inflammation and Immunity Pathways Regulate Genetic Susceptibility to Diabetic Nephropathy. 
  • Influence of genetic background on albuminuria and kidney injury in Ins2(+/C96Y) (Akita) mice. 
  • Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras. 
  • Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis. 
  • Inhibitory role of CD19 in the progression of experimental autoimmune encephalomyelitis by regulating cytokine response. 
  • Initiation of immune tolerance-controlled HIV gp41 neutralizing B cell lineages. 
  • Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism. 
  • Insufficient luteinizing hormone-induced intracellular signaling disrupts ovulation in preovulatory follicles lacking estrogen receptor-{beta}. 
  • Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice. 
  • Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin. 
  • Intracardiac septation requires hedgehog-dependent cellular contributions from outside the heart. 
  • Iron deficiency: lessons from anemic mice. 
  • Isolation of a candidate cDNA for the gene causing retinal degeneration in the rd mouse. 
  • Knock-in mutation of the distal four tyrosines of linker for activation of T cells blocks murine T cell development. 
  • Knockin mice expressing a chimeric p53 protein reveal mechanistic differences in how p53 triggers apoptosis and senescence. 
  • Kv3.1b is a novel component of CNS nodes. 
  • L-selectin-deficient mice have impaired leukocyte recruitment into inflammatory sites. 
  • LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling. 
  • Learning. A mechanism of learning found? 
  • Leukocyte interactions with vascular endothelium. New insights into selectin-mediated attachment and rolling. 
  • Limbic epilepsy in transgenic mice carrying a Ca2+/calmodulin-dependent kinase II alpha-subunit mutation. 
  • Localization and interaction of NHERF isoforms in the renal proximal tubule of the mouse. 
  • Localization of a retroviral element within the rd gene coding for the beta subunit of cGMP phosphodiesterase. 
  • Long-term type 1 diabetes influences haematopoietic stem cells by reducing vascular repair potential and increasing inflammatory monocyte generation in a murine model. 
  • Lupus autoantibodies interact directly with distinct glomerular and vascular cell surface antigens. 
  • Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice. 
  • Mammalian iron transport: an unexpected link between metal homeostasis and host defense. 
  • Manganese superoxide dismutase expression in endothelial progenitor cells accelerates wound healing in diabetic mice. 
  • Mast cell activators: a new class of highly effective vaccine adjuvants. 
  • Mechanisms of polyclonal B-cell activation in autoimmune B6-lpr/lpr mice. 
  • Melanocortin-1 receptor gene variants affect pain and mu-opioid analgesia in mice and humans. 
  • Mice lacking Bmp6 function. 
  • Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization. 
  • Mice lacking expression of the chemokines CCL21-ser and CCL19 (plt mice) demonstrate delayed but enhanced T cell immune responses. 
  • Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis. 
  • Mice with duplications and deletions at the Tme locus have altered MnSOD activity. 
  • Microcytic anemia in mk/mk mice is not corrected by retroviral-mediated gene transfer of wild-type p45 NF-E2. 
  • Modelling the effects of age-related mtDNA mutation accumulation; complex I deficiency, superoxide and cell death. 
  • Modulation of IA currents by capsaicin in rat trigeminal ganglion neurons. 
  • Modulation of the transformed and neoplastic phenotype of rat fibroblasts by MHC-I gene expression. 
  • Molecular and structural analysis of nuclear localizing anti-DNA lupus antibodies. 
  • Mouse model of Timothy syndrome recapitulates triad of autistic traits. 
  • Mouse small eye results from mutations in a paired-like homeobox-containing gene. 
  • Multiple Nod-like receptors activate caspase 1 during Listeria monocytogenes infection. 
  • Murine forkhead/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract. 
  • Murine leptin deficiency alters Kupffer cell production of cytokines that regulate the innate immune system. 
  • Mutant IDH is sufficient to initiate enchondromatosis in mice. 
  • Mutant mice and neuroscience: recommendations concerning genetic background. Banbury Conference on genetic background in mice. 
  • Mutation in the mismatch repair gene Msh6 causes cancer susceptibility. 
  • Mutation of MeCP2 alters transcriptional regulation of select immediate-early genes. 
  • NHERF-1 is required for renal adaptation to a low-phosphate diet. 
  • NIP45 controls the magnitude of the type 2 T helper cell response. 
  • NLRP3 Promotes Diabetic Bladder Dysfunction and Changes in Symptom-Specific Bladder Innervation. 
  • Negative regulation of mTOR activation by diacylglycerol kinases. 
  • Neonatal W-mutant mice are favorable hosts for tracking development of marked hematopoietic stem cells. 
  • Neutrophil margination, sequestration, and emigration in the lungs of L-selectin-deficient mice. 
  • Oncolytic virus-derived type I interferon restricts CAR T cell therapy. 
  • Oval cells compensate for damage and replicative senescence of mature hepatocytes in mice with fatty liver disease. 
  • PI3K regulation of RAC1 is required for KRAS-induced pancreatic tumorigenesis in mice. 
  • Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis. 
  • Partial suppression of anchorage-independent growth and tumorigenicity in immunodeficient mice by transfection of the H-2 class I gene H-2Ld into a human colon cancer cell line (HCT). 
  • Passive ventricular mechanics in tight-skin mice. 
  • Pathogenicity of Saccharomyces cerevisiae in complement factor five-deficient mice. 
  • Peptidylglycine α-amidating monooxygenase heterozygosity alters brain copper handling with region specificity. 
  • Perivascular dendritic cells elicit anaphylaxis by relaying allergens to mast cells via microvesicles. 
  • Permanent survival of fully MHC-mismatched islet allografts by targeting a single chemokine receptor pathway. 
  • Peroxisome proliferator-activated receptor γ co-activator 1-α as a critical co-activator of the murine hepatic oxidative stress response and mitochondrial biogenesis in Staphylococcus aureus sepsis. 
  • Pressure overload selectively up-regulates Ca2+/calmodulin-dependent protein kinase II in vivo. 
  • Progesterone receptor isoform B regulates the Oxtr-Plcl2-Trpc3 pathway to suppress uterine contractility. 
  • Prostaglandin E2 induction during mouse adenovirus type 1 respiratory infection regulates inflammatory mediator generation but does not affect viral pathogenesis. 
  • Purkinje cell degeneration associated with erythroid ankyrin deficiency in nb/nb mice. 
  • RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism. 
  • Reduction of seizures by transplantation of cortical GABAergic interneuron precursors into Kv1.1 mutant mice. 
  • Regulation of T cell receptor-alpha gene recombination by transcription. 
  • Regulation of iron absorption in Hfe mutant mice. 
  • Regulation of macrophage motility by Irgm1. 
  • Regulation of male germ cell cycle arrest and differentiation by DND1 is modulated by genetic background. 
  • Regulation of the B cell response to T-dependent antigens by classical pathway complement. 
  • Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis. 
  • RelB modulation of IkappaBalpha stability as a mechanism of transcription suppression of interleukin-1alpha (IL-1alpha), IL-1beta, and tumor necrosis factor alpha in fibroblasts. 
  • Restrictive Lung Disease in the Cu/Zn Superoxide-Dismutase 1 G93A Amyotrophic Lateral Sclerosis Mouse Model. 
  • Retinal degeneration in the rd mouse is caused by a defect in the beta subunit of rod cGMP-phosphodiesterase. 
  • Retinitis in euthymic mice following inoculation of murine cytomegalovirus (MCMV) via the supraciliary route. 
  • Role for cytoplasmic nucleotide hydrolysis in hepatic function and protein synthesis. 
  • Role of GSK3 beta in behavioral abnormalities induced by serotonin deficiency. 
  • Role of glutamic acid decarboxylase 67 in regulating cortical parvalbumin and GABA membrane transporter 1 expression: implications for schizophrenia. 
  • SR1, a mouse odorant receptor with an unusually broad response profile. 
  • Seizure disorders in mutant mice: relevance to human epilepsies. 
  • Seizure predisposition after perinatal hypoxia: effects of subsequent age and of an epilepsy predisposing gene mutation. 
  • Selective recognition of DNA antigenic determinants by murine monoclonal anti-DNA antibodies. 
  • Skeletal abnormalities in doubly heterozygous Bmp4 and Bmp7 mice. 
  • Skewed VH and V kappa gene family expression and pairing occurs among B lymphocytes in autoimmune motheaten mice. 
  • Small eye (Sey): a mouse model for the genetic analysis of craniofacial abnormalities. 
  • Smoothelin-like 1 protein regulates myosin phosphatase-targeting subunit 1 expression during sexual development and pregnancy. 
  • Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder. 
  • Sox2 is required for development of taste bud sensory cells. 
  • Specificity and idiotype analysis of a monoclonal anti-DNA antibody. 
  • Spermatogonial depletion in adult Pin1-deficient mice. 
  • Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse. 
  • Studies leading to the isolation of a cDNA for the gene causing retinal degeneration in the rd mouse. 
  • Suppressor of fused (Sufu) mediates the effect of parathyroid hormone-like hormone (Pthlh) on chondrocyte differentiation in the growth plate. 
  • Surfactant protein-A inhibits mycoplasma-induced dendritic cell maturation through regulation of HMGB-1 cytokine activity. 
  • Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus. 
  • Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction. 
  • Targeted selection of HIV-specific antibody mutations by engineering B cell maturation. 
  • Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis. 
  • Targeting sonic hedgehog-associated medulloblastoma through inhibition of Aurora and Polo-like kinases. 
  • The CD19 signal transduction molecule is a response regulator of B-lymphocyte differentiation. 
  • The G185R mutation disrupts function of the iron transporter Nramp2. 
  • The Nramp2/DMT1 iron transporter is induced in the duodenum of microcytic anemia mk mice but is not properly targeted to the intestinal brush border. 
  • The Smads: transcriptional regulation and mouse models. 
  • The aminopeptidase ERAAP shapes the peptide repertoire displayed by major histocompatibility complex class I molecules. 
  • The chromosomal mapping of four genes encoding winged helix proteins expressed early in mouse development. 
  • The common gamma-chain of cytokine receptors regulates intrathymic T cell development at multiple stages. 
  • The effects of short-term treatment with the prostaglandin E1 (PGE1) analog misoprostol on inflammatory mediator production in murine lupus nephritis. 
  • The essential role of LAT in thymocyte development during transition from the double-positive to single-positive stage. 
  • The extracellular matrix protein mindin serves as an integrin ligand and is critical for inflammatory cell recruitment. 
  • The fine specificity of monoclonal anti-DNA antibodies induced in normal mice by immunization with bacterial DNA. 
  • The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse. 
  • The gene encoding proline dehydrogenase modulates sensorimotor gating in mice. 
  • The genetics of autoantibody production in MRL/lpr lupus mice. 
  • The glucocorticoid hormone signal transduction pathway in mice homozygous for chromosomal deletions causing failure of cell type-specific inducible gene expression. 
  • The hormone receptor GUCY2C suppresses intestinal tumor formation by inhibiting AKT signaling. 
  • The importance of Src homology 2 domain-containing leukocyte phosphoprotein of 76 kilodaltons sterile-alpha motif domain in thymic selection and T-cell activation. 
  • The indispensability of heme oxygenase-1 in protecting against acute heme protein-induced toxicity in vivo. 
  • The inducible deletion of Drosha and microRNAs in mature podocytes results in a collapsing glomerulopathy. 
  • The influence of variable-region somatic mutations on the specificity and pathogenicity of murine monoclonal anti-DNA antibodies. 
  • The loss of PIN1 deregulates cyclin E and sensitizes mouse embryo fibroblasts to genomic instability. 
  • The mammalian Tolloid-like 1 gene, Tll1, is necessary for normal septation and positioning of the heart. 
  • The mechanism of autoantibody production in an autoimmune MRL/lpr mouse. 
  • The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis. 
  • The near-naked hairless (Hr(N)) mutation disrupts hair formation but is not due to a mutation in the Hairless coding region. 
  • The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors. 
  • The nuclear receptor steroidogenic factor 1 acts at multiple levels of the reproductive axis. 
  • The regulation of skeletal muscle protein turnover during the progression of cancer cachexia in the Apc(Min/+) mouse. 
  • The role of the extracellular matrix protein mindin in airway response to environmental airways injury. 
  • The secreted metalloprotease ADAMTS20 is required for melanoblast survival. 
  • The secretory granule matrix-electrolyte interface: a homologue of the p-n rectifying junction. 
  • The spatial and temporal origin of chandelier cells in mouse neocortex. 
  • The structure and function of gamma c-dependent cytokines and receptors: regulation of T lymphocyte development and homeostasis. 
  • The winged helix gene, Mf3, is required for normal development of the diencephalon and midbrain, postnatal growth and the milk-ejection reflex. 
  • The winged helix transcription factor MFH1 is required for proliferation and patterning of paraxial mesoderm in the mouse embryo. 
  • Thrombospondin-1 is a major activator of TGF-beta1 in vivo. 
  • Thrombospondin-1 modulates vascular endothelial growth factor activity at the receptor level. 
  • Thromboxane receptor blockade reduces renal injury in murine lupus nephritis. 
  • Topical lineage-negative progenitor-cell therapy for diabetic wounds. 
  • Transcriptional profiling of the Sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursors. 
  • Transferrin receptor is necessary for development of erythrocytes and the nervous system. 
  • Use of genetically modified mouse models for evaluation of carcinogenic risk: considerations for the laboratory animal scientist. 
  • V region gene analysis of anti-Sm hybridomas from MRL/Mp-lpr/lpr mice. 
  • Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH. 
  • Vitamin E inhibits abdominal aortic aneurysm formation in angiotensin II-infused apolipoprotein E-deficient mice. 
  • beta(3)-adrenoceptor deficiency blocks nitric oxide-dependent inhibition of myocardial contractility. 
  • c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis. 
  • c-Kit is essential for alveolar maintenance and protection from emphysema-like disease in mice. 
  • mRNAs coding for proteins of the cGMP cascade in the degenerative retina of the rd mouse. 
  • mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1. 
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  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Bowes Rickman, Catherine, George and Geneva Boguslavsky Distinguished Professor of Eye Research, Cell Biology
  • Choi, Steven Sok, Associate Professor of Medicine, Medicine, Gastroenterology
  • Ciofani, Maria, Associate Professor of Integrative Immunobiology, Cell Biology
  • Gunn, Michael Dee, Professor of Medicine, Integrative Immunobiology
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • Kelsoe, Garnett H., James B. Duke Distinguished Professor of Immunology, Integrative Immunobiology
  • Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Integrative Immunobiology
  • Laskowitz, Daniel Todd, Professor of Neurology, Duke Science & Society
  • Liu, Yutao, Adjunct Assistant Professor in the Department of Medicine, Medicine, Medical Genetics
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Schmehl, Meredith, Student, Neurobiology
  • Shinohara, Mari L., Professor of Integrative Immunobiology, Cell Biology
  • Taylor, Gregory Alan, Professor in Medicine, Integrative Immunobiology