Mice, Neurologic Mutants

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  Subject Areas on Research

  • 440-kD ankyrinB: structure of the major developmentally regulated domain and selective localization in unmyelinated axons. 
  • ALSUntangled No. 34: GM604. 
  • ALSUntangled No. 35: Hyperbaric Oxygen Therapy. 
  • Age-related congophilic inclusions in the brains of apolipoprotein E-deficient mice. 
  • Age-related relationship between mRNA expression of GABA(B) receptors and calcium channel beta4 subunits in cacnb4lh mice. 
  • Alteration of IGF system gene expression during the postnatal development of pcd mice. 
  • An intrinsic neuronal defect operates in dystonia musculorum: a study of dt/dt<==>+/+ chimeras. 
  • An olfactory sensory map develops in the absence of normal projection neurons or GABAergic interneurons. 
  • ApoER2 function in the establishment and maintenance of retinal synaptic connectivity. 
  • Apolipoprotein E and Reelin ligands modulate tau phosphorylation through an apolipoprotein E receptor/disabled-1/glycogen synthase kinase-3beta cascade. 
  • Applicability and limitations of MR tracking of neural stem cells with asymmetric cell division and rapid turnover: the case of the shiverer dysmyelinated mouse brain. 
  • Assignment of the gene for myelin proteolipid protein to the X chromosome: implications for X-linked myelin disorders. 
  • Decreased (45)Ca(2)(+) uptake in P/Q-type calcium channels in homozygous lethargic (Cacnb4lh) mice is associated with increased beta3 and decreased beta4 calcium channel subunit mRNA expression. 
  • Decreased IGF-I gene expression during the apoptosis of Purkinje cells in pcd mice. 
  • Elevated intracellular calcium levels in cerebellar granule neurons of weaver mice. 
  • Enhanced subcortical spreading depression in familial hemiplegic migraine type 1 mutant mice. 
  • Excitatory but not inhibitory synaptic transmission is reduced in lethargic (Cacnb4(lh)) and tottering (Cacna1atg) mouse thalami. 
  • Glutamate decarboxylase isoforms in thalamic nuclei in lethargic mouse model of absence seizures. 
  • Glycine receptor beta-subunit gene mutation in spastic mouse associated with LINE-1 element insertion. 
  • Graft-induced restoration of function in hereditary cerebellar ataxia. 
  • Grafted cerebellar cells in a mouse model of hereditary ataxia express IGF-I system genes and partially restore behavioral function. 
  • Hereditary motor and sensory neuropathies. 
  • High-field (9.4 T) MRI of brain dysmyelination by quantitative mapping of magnetic susceptibility. 
  • Hypomyelination in the peripheral nervous system of shiverer mice and in shiverer in equilibrium normal chimaera. 
  • Impairment in motor learning of somatostatin null mutant mice. 
  • Impairment of synaptic vesicle clustering and of synaptic transmission, and increased seizure propensity, in synapsin I-deficient mice. 
  • Increased number of GABAB receptors in the lethargic (lh/lh) mouse model of absence epilepsy. 
  • Intracellular trafficking of histone deacetylase 4 regulates neuronal cell death. 
  • Kindling and associated mossy fibre sprouting are not affected in mice deficient of NGFI-A/NGFI-B genes. 
  • Knockout of the vesicular monoamine transporter 2 gene results in neonatal death and supersensitivity to cocaine and amphetamine. 
  • Local calcium release in dendritic spines required for long-term synaptic depression. 
  • Magnetic susceptibility anisotropy of human brain in vivo and its molecular underpinnings. 
  • Mechanisms of increased hippocampal excitability in the Mashl+/- mouse model of Na+ /K+ -ATPase dysfunction. 
  • Neuroanatomical phenotypes in the reeler mouse. 
  • Normal basal laminas are realized on dystrophic Schwann cells in dystrophic in equilibrium shiverer chimera nerves. 
  • Orphan nuclear receptors in T lymphocyte development. 
  • Rescue of neurological deficits in a mouse model for Angelman syndrome by reduction of alphaCaMKII inhibitory phosphorylation. 
  • Sodium channel density in hypomyelinated brain increased by myelin basic protein gene deletion. 
  • Stargazing nets new calcium channel subunit. 
  • Studies of the lethargic (lh/lh) mouse model of absence seizures: regulatory mechanisms and identification of the lh gene. 
  • The forkhead/winged helix gene Mf1 is disrupted in the pleiotropic mouse mutation congenital hydrocephalus. 
  • The reeler gene encodes a protein with an EGF-like motif expressed by pioneer neurons. 
  • The role of GABAB mechanisms in animal models of absence seizures. 
  • Tracking brain volume changes in C57BL/6J and ApoE-deficient mice in a model of neurodegeneration: a 5-week longitudinal micro-MRI study. 
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  Keywords of People

  • Bennett, Vann, George B. Geller Professor for Research in Molecular Biology in the School of Medicine, Duke Cancer Institute
  • Hogan, Brigid L. M., George Barth Geller Professor, Cell Biology
  • Johnson, G. Allan, Charles E. Putman University Professor of Radiology, Physics
  • Warner, David Samuel, Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology