Mice, Neurologic Mutants

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  Subject Areas on Research

  • 440-kD ankyrinB: structure of the major developmentally regulated domain and selective localization in unmyelinated axons. 
  • ALSUntangled No. 34: GM604. 
  • ALSUntangled No. 35: Hyperbaric Oxygen Therapy. 
  • Alteration of IGF system gene expression during the postnatal development of pcd mice. 
  • An olfactory sensory map develops in the absence of normal projection neurons or GABAergic interneurons. 
  • ApoER2 function in the establishment and maintenance of retinal synaptic connectivity. 
  • Apolipoprotein E and Reelin ligands modulate tau phosphorylation through an apolipoprotein E receptor/disabled-1/glycogen synthase kinase-3beta cascade. 
  • Decreased IGF-I gene expression during the apoptosis of Purkinje cells in pcd mice. 
  • Enhanced subcortical spreading depression in familial hemiplegic migraine type 1 mutant mice. 
  • Glycine receptor beta-subunit gene mutation in spastic mouse associated with LINE-1 element insertion. 
  • Graft-induced restoration of function in hereditary cerebellar ataxia. 
  • Grafted cerebellar cells in a mouse model of hereditary ataxia express IGF-I system genes and partially restore behavioral function. 
  • High-field (9.4 T) MRI of brain dysmyelination by quantitative mapping of magnetic susceptibility. 
  • Impairment of synaptic vesicle clustering and of synaptic transmission, and increased seizure propensity, in synapsin I-deficient mice. 
  • Intracellular trafficking of histone deacetylase 4 regulates neuronal cell death. 
  • Kindling and associated mossy fibre sprouting are not affected in mice deficient of NGFI-A/NGFI-B genes. 
  • Knockout of the vesicular monoamine transporter 2 gene results in neonatal death and supersensitivity to cocaine and amphetamine. 
  • Mechanisms of increased hippocampal excitability in the Mashl+/- mouse model of Na+ /K+ -ATPase dysfunction. 
  • Neuroanatomical phenotypes in the reeler mouse. 
  • Orphan nuclear receptors in T lymphocyte development. 
  • Sodium channel density in hypomyelinated brain increased by myelin basic protein gene deletion. 
  • Stargazing nets new calcium channel subunit. 
  • The forkhead/winged helix gene Mf1 is disrupted in the pleiotropic mouse mutation congenital hydrocephalus. 
  • Tracking brain volume changes in C57BL/6J and ApoE-deficient mice in a model of neurodegeneration: a 5-week longitudinal micro-MRI study. 
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  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Hogan, Brigid L. M., George Barth Geller Distinguished Professor for Research in Molecular Biology, Cell Biology
  • Johnson, G. Allan, Charles E. Putman University Distinguished Professor of Radiology, Biomedical Engineering
  • Warner, David Samuel, Distinguished Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology