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Subject Areas on Research
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14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening.
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4.5 kb of the rat tyrosine hydroxylase 5' flanking sequence directs tissue specific expression during development and contains consensus sites for multiple transcription factors.
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5' flanking sequences of the rat tyrosine hydroxylase gene target accurate tissue-specific, developmental, and transsynaptic expression in transgenic mice.
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A CNS catecholaminergic cell line expresses voltage-gated currents.
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A Cre-inducible fluorescent reporter for observing apical membrane dynamics.
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A GABAergic nigrotectal pathway for coordination of drinking behavior.
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A Gαs DREADD mouse for selective modulation of cAMP production in striatopallidal neurons.
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A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy.
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A PIK3C3-ankyrin-B-dynactin pathway promotes axonal growth and multiorganelle transport.
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A Peptide Uncoupling BDNF Receptor TrkB from Phospholipase Cγ1 Prevents Epilepsy Induced by Status Epilepticus.
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A balance between B cell receptor and inhibitory receptor signaling controls plasma cell differentiation by maintaining optimal Ets1 levels.
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A barrier-type insulator forms a boundary between active and inactive chromatin at the murine TCRβ locus.
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A c-Myc and surface CD19 signaling amplification loop promotes B cell lymphoma development and progression in mice.
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A cerebellar learning model of vestibulo-ocular reflex adaptation in wild-type and mutant mice.
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A comparison of strain-related susceptibility in two murine recovery models of global cerebral ischemia.
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A conserved Pbx-Wnt-p63-Irf6 regulatory module controls face morphogenesis by promoting epithelial apoptosis.
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A critical role for direct TLR2-MyD88 signaling in CD8 T-cell clonal expansion and memory formation following vaccinia viral infection.
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A defect in the humoral immune response to protein antigens and haptens in immunoglobulin mu heavy-chain transgenic mice.
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A developmental switch from TCR delta enhancer to TCR alpha enhancer function during thymocyte maturation.
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A direct HDAC4-MAP kinase crosstalk activates muscle atrophy program.
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A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis.
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A functional role for circulating mouse L-selectin in regulating leukocyte/endothelial cell interactions in vivo.
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A gammaGT-AT1A receptor transgene protects renal cortical structure in AT1 receptor-deficient mice.
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A genome end-game: understanding gene function in the nervous system.
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A greater role for the norepinephrine transporter than the serotonin transporter in murine nociception.
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A hierarchy of ankyrin-spectrin complexes clusters sodium channels at nodes of Ranvier.
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A high mitochondrial transport rate characterizes CNS neurons with high axonal regeneration capacity.
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A human immunoglobulin gene reduces the incidence of lymphomas in c-Myc-bearing transgenic mice.
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A lymphotoxin-IFN-beta axis essential for lymphocyte survival revealed during cytomegalovirus infection.
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A macrophage subpopulation recruited by CC chemokine ligand-2 clears apoptotic cells in noninfectious lung injury.
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A mitotic recombination system for mouse chromosome 17.
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A murine Ig light chain transgene reveals IGKV3 gene contributions to anti-collagen types IV and II specificities.
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A mutant PTH/PTHrP type I receptor in enchondromatosis.
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A neuronal model of Alzheimer's disease: an insight into the mechanisms of oxidative stress-mediated mitochondrial injury.
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A new millenium for spinal cord regeneration: growth-associated genes.
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A nonpolio enterovirus with respiratory tropism causes poliomyelitis in intercellular adhesion molecule 1 transgenic mice.
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A novel SV40 TAg transgenic model of asbestos-induced mesothelioma: malignant transformation is dose dependent.
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A novel apoE-derived therapeutic reduces vasospasm and improves outcome in a murine model of subarachnoid hemorrhage.
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A novel mouse model of depletion of stellate cells clarifies their role in ischemia/reperfusion- and endotoxin-induced acute liver injury.
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A novel mouse model of podocyte depletion.
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A novel redox regulator, MnTnBuOE-2-PyP5+, enhances normal hematopoietic stem/progenitor cell function.
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A novel role for HEB downstream or parallel to the pre-TCR signaling pathway during alpha beta thymopoiesis.
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A prior feature SVM-MRF based method for mouse brain segmentation.
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A protocol for imaging alternative splicing regulation in vivo using fluorescence reporters in transgenic mice.
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A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses.
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A role for MAPK in feedback inhibition of Tcrb recombination.
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A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program.
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A role for a lithium-inhibited Golgi nucleotidase in skeletal development and sulfation.
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A role for fractalkine and its receptor (CX3CR1) in cardiac allograft rejection.
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A role for histone acetylation in the developmental regulation of VDJ recombination.
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A role for the cytoplasmic tail of the beta chain of CD8 in thymic selection.
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A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection.
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A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase.
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A threshold for central T cell tolerance to an inducible serum protein.
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A transgenic mouse prostate cancer model.
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A unique role of the DNA fragmentation factor in maintaining genomic stability.
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ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects.
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AMH induces mesonephric cell migration in XX gonads.
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APOE Genotype Differentially Modulates Effects of Anti-Aβ, Passive Immunization in APP Transgenic Mice.
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APOE Isoforms Control Pathogenic Subretinal Inflammation in Age-Related Macular Degeneration.
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APOE genotype-specific differences in the innate immune response.
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APOE-mimetic peptides reduce behavioral deficits, plaques and tangles in Alzheimer's disease transgenics.
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APOE4-VLDL inhibits the HDL-activated phosphatidylinositol 3-kinase/Akt Pathway via the phosphoinositol phosphatase SHIP2.
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APOL1 variants increase risk for FSGS and HIVAN but not IgA nephropathy.
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APOL1-G0 or APOL1-G2 Transgenic Models Develop Preeclampsia but Not Kidney Disease.
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ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS.
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Abeta42 neurotoxicity in primary co-cultures: effect of apoE isoform and Abeta conformation.
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Ablation of steroid receptor coactivator-3 resembles the human CACT metabolic myopathy.
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Abnormal cerebellar signaling induces dystonia in mice.
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Abnormal osmotic regulation in trpv4-/- mice.
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Abundant expression of ponsin, a focal adhesion protein, in lens and downregulation of its expression by impaired cytoskeletal signaling.
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Acceleration of mammary neoplasia in transforming growth factor alpha transgenic mice by 7,12-dimethylbenzanthracene.
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Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity and lymphoma.
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Activated B cells modified by electroporation of multiple mRNAs encoding immune stimulatory molecules are comparable to mature dendritic cells in inducing in vitro antigen-specific T-cell responses.
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Activated microglia proliferate at neurites of mutant huntingtin-expressing neurons.
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Activation of Galpha q-coupled signaling pathways in glomerular podocytes promotes renal injury.
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Activation of MEF2 by muscle activity is mediated through a calcineurin-dependent pathway.
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Activation of Nrf2 Is Required for Normal and ChREBPα-Augmented Glucose-Stimulated β-Cell Proliferation.
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Activation of hedgehog signaling during fracture repair enhances osteoblastic-dependent matrix formation.
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Activation of matrix metalloproteinases following anti-Aβ immunotherapy; implications for microhemorrhage occurrence.
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Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors.
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Activation of the canonical bone morphogenetic protein (BMP) pathway during lung morphogenesis and adult lung tissue repair.
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Activin enhances skin tumourigenesis and malignant progression by inducing a pro-tumourigenic immune cell response.
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Acute in vivo genetic rescue demonstrates that phosphorylation of RIM1alpha serine 413 is not required for mossy fiber long-term potentiation.
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Acute organ failure following the loss of anti-apoptotic cellular FLICE-inhibitory protein involves activation of innate immune receptors.
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Adaptation of an ICAM-1-tropic enterovirus to the mouse respiratory tract.
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Adeno-associated virus-delivered artificial microRNA extends survival and delays paralysis in an amyotrophic lateral sclerosis mouse model.
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Adult enteric nervous system in health is maintained by a dynamic balance between neuronal apoptosis and neurogenesis.
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Adult murine hippocampal neurogenesis is inhibited by sustained IL-1β and not rescued by voluntary running.
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Adverse effects of constitutively active alpha(1B)-adrenergic receptors after pressure overload in mouse hearts.
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Adynamic Bone Decreases Bone Toughness During Aging by Affecting Mineral and Matrix.
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Aerobic training as an adjunctive therapy to enzyme replacement in Pompe disease.
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Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis.
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Age-dependent impairment of glucose tolerance in the 3xTg-AD mouse model of Alzheimer's disease.
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Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD mice.
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Airway epithelial cell expression of interleukin-6 in transgenic mice. Uncoupling of airway inflammation and bronchial hyperreactivity.
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Airway injury in lung disease pathophysiology: selective depletion of airway stem and progenitor cell pools potentiates lung inflammation and alveolar dysfunction.
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Airway-specific inducible transgene expression using aerosolized doxycycline.
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Akt/protein kinase B promotes organ growth in transgenic mice.
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Allelic exclusion of mouse T cell receptor alpha chains occurs at the time of thymocyte TCR up-regulation.
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Allelic exclusion of the TCR alpha-chain is an active process requiring TCR-mediated signaling and c-Cbl.
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Allergic inflammation induces a persistent mechanistic switch in thromboxane-mediated airway constriction in the mouse.
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Alloimmune lung injury induced by local innate immune activation through inhaled lipopolysaccharide.
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Allospecific CD4(+) effector memory T cells do not induce graft-versus-host disease in mice.
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Alterations in calcium channel currents underlie defective insulin secretion in a transgenic mouse.
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Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy.
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Alterations in slow-twitch muscle phenotype in transgenic mice overexpressing the Ca2+ buffering protein parvalbumin.
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Altered airway and cardiac responses in mice lacking G protein-coupled receptor kinase 3.
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Altered neurotransmission in the lateral amygdala in aged human apoE4 targeted replacement mice.
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Altered toll-like receptor responsiveness underlies a dominant heritable defect in B cell tolerance in autoimmune New Zealand Black mice.
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Amelioration of inflammatory arthritis by targeting the pre-ligand assembly domain of tumor necrosis factor receptors.
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Amino acids stimulate cholecystokinin release through the Ca2+-sensing receptor.
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Amyloid reduction by amyloid-beta vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of Alzheimer's disease.
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An Ectopic CTCF Binding Element Inhibits Tcrd Rearrangement by Limiting Contact between Vδ and Dδ Gene Segments.
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An adenoviral vaccine encoding full-length inactivated human Her2 exhibits potent immunogenicty and enhanced therapeutic efficacy without oncogenicity.
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An analysis of T cell intrinsic roles of E2A by conditional gene disruption in the thymus.
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An apolipoprotein E-based therapeutic improves outcome and reduces Alzheimer's disease pathology following closed head injury: evidence of pharmacogenomic interaction.
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An essential role of Bmp4 in the atrioventricular septation of the mouse heart.
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An imaging-based approach to identify ligands for olfactory receptors.
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An immunoglobulin C kappa-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune system.
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An important role of phospholipase Cgamma1 in pre-B-cell development and allelic exclusion.
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An interdomain interaction of the androgen receptor is required for its aggregation and toxicity in spinal and bulbar muscular atrophy.
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Analysis of the role of membrane polarity in polycystic kidney disease of transgenic SBM mice.
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Analyzing somatosensory axon projections with the sensory neuron-specific Advillin gene.
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Androgen-independent prostate cancer progression in the TRAMP model.
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Androgen-mediated immune function is altered by the apolipoprotein E gene.
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Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity.
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Angiotensin II type 1 receptor-associated protein is an endogenous inhibitor of angiotensin II type 1 receptor action in cardiac hypertrophy: role in check and balance.
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Angiotensin II type 1A receptors in vascular smooth muscle cells do not influence aortic remodeling in hypertension.
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Angiotensin-converting enzyme 2 gene targeting studies in mice: mixed messages.
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Animal models of steatohepatitis.
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Anti-TCR mAb induces peripheral tolerance to alloantigens and delays islet allograft rejection in autoimmune diabetic NOD mice.
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Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration.
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Anti-amyloid-beta immunotherapy in Alzheimer's disease: relevance of transgenic mouse studies to clinical trials.
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Antibody-mediated B-cell depletion before adoptive immunotherapy with T cells expressing CD20-specific chimeric T-cell receptors facilitates eradication of leukemia in immunocompetent mice.
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Antigen-specific induced Foxp3+ regulatory T cells are generated following CD40/CD154 blockade.
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Antimicrobial activity of PLUNC protects against Pseudomonas aeruginosa infection.
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Antiseizure effects of TrkB kinase inhibition.
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Antitumorigenesis of antioxidants in a transgenic Rac1 model of Kaposi's sarcoma.
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ApoE isoform affects LTP in human targeted replacement mice.
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ApoE isoform-specific effects on LTP: blockade by oligomeric amyloid-beta1-42.
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ApoE, Alzheimer's disease, and recovery from brain stress.
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ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy.
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Apolipoprotein E Exerts a Whole-Brain Protective Property by Promoting M1? Microglia Quiescence After Experimental Subarachnoid Hemorrhage in Mice.
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Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration.
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Apolipoprotein E and the CNS response to injury.
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Apolipoprotein E isoform-specific differences in outcome from focal ischemia in transgenic mice.
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Apolipoprotein E isotype-dependent modulation of microRNA-146a in plasma and brain.
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Apolipoprotein E knock-out and knock-in mice: atherosclerosis, metabolic syndrome, and beyond.
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Apolipoprotein E level and cholesterol are associated with reduced synaptic amyloid beta in Alzheimer's disease and apoE TR mouse cortex.
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Apolipoprotein E plays a key role against cryptosporidial infection in transgenic undernourished mice.
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Apolipoprotein E-low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner.
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Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes.
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Apolipoprotein E4 exaggerates diabetic dyslipidemia and atherosclerosis in mice lacking the LDL receptor.
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Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease.
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Arthritis syndromes associated with human T cell lymphotropic virus type I infection.
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Aryl hydrocarbon receptor activation in genital tubercle, palate, and other embryonic tissues in 2,3,7, 8-tetrachlorodibenzo-p-dioxin-responsive lacZ mice.
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Aspartyl-(asparaginyl)-beta-hydroxylase regulates hepatocellular carcinoma invasiveness.
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Assembly of the dystrophin-associated protein complex does not require the dystrophin COOH-terminal domain.
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Assessing a role for enhancer-blocking activity in gene regulation within the murine T-cell receptor alpha/delta locus.
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Atm deletion with dual recombinase technology preferentially radiosensitizes tumor endothelium.
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Atomic description of the immune complex involved in heparin-induced thrombocytopenia.
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Attenuation of cerebral vasospasm after subarachnoid hemorrhage in mice overexpressing extracellular superoxide dismutase.
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Augmentation of cardiac contractility mediated by the human beta(3)-adrenergic receptor overexpressed in the hearts of transgenic mice.
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Autofeedback suppression of growth hormone (GH) secretion in transgenic mice expressing a human GH reporter targeted by tyrosine hydroxylase 5'-flanking sequences to the hypothalamus.
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Autonomic nerve development contributes to prostate cancer progression.
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Autophagy is essential for mitochondrial clearance in mature T lymphocytes.
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Autophagy regulates T lymphocyte proliferation through selective degradation of the cell-cycle inhibitor CDKN1B/p27Kip1.
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Autophagy regulates endoplasmic reticulum homeostasis and calcium mobilization in T lymphocytes.
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Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide.
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Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activities.
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Autoreactivity in an HIV-1 broadly reactive neutralizing antibody variable region heavy chain induces immunologic tolerance.
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B Lymphocyte signaling established by the CD19/CD22 loop regulates autoimmunity in the tight-skin mouse.
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B cells are required for optimal CD4+ and CD8+ T cell tumor immunity: therapeutic B cell depletion enhances B16 melanoma growth in mice.
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B lymphocytes differentially influence acute and chronic allograft rejection in mice.
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B-1a and B-1b cells exhibit distinct developmental requirements and have unique functional roles in innate and adaptive immunity to S. pneumoniae.
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B-Cell Depletion Reduces the Maturation of Cerebral Cavernous Malformations in Murine Models.
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B-cell depletion in vitro and in vivo with an afucosylated anti-CD19 antibody.
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B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB.
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BMP antagonism by Noggin is required in presumptive notochord cells for mammalian foregut morphogenesis.
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Basal B cell receptor-directed phosphatidylinositol 3-kinase signaling turns off RAGs and promotes B cell-positive selection.
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Basal cells are a multipotent progenitor capable of renewing the bronchial epithelium.
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Basal laminar deposit formation in APO B100 transgenic mice: complex interactions between dietary fat, blue light, and vitamin E.
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Bcl-2 accelerates multistep prostate carcinogenesis in vivo.
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Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice.
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Beta-arrestin-2 regulates the development of allergic asthma.
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Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection.
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Beta-catenin is a mediator of the response of fibroblasts to irradiation.
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Beta-catenin regulates wound size and mediates the effect of TGF-beta in cutaneous healing.
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Beta-catenin signaling pathway is crucial for bone morphogenetic protein 2 to induce new bone formation.
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Beta-catenin signaling plays a disparate role in different phases of fracture repair: implications for therapy to improve bone healing.
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Beta2-adrenergic receptor overexpression in the developing mouse heart: evidence for targeted modulation of ion channels.
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Bi-ligand surfaces with oriented and patterned protein for real-time tracking of cell migration.
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Biallelic mutations in FDXR cause neurodegeneration associated with inflammation.
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Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells.
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Bioenergetic defect associated with mKATP channel opening in a mouse model carrying a mitofusin 2 mutation.
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Biomimetic hydrogels with immobilized ephrinA1 for therapeutic angiogenesis.
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Black cohosh increases metastatic mammary cancer in transgenic mice expressing c-erbB2.
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Blockade of nicotinic acetylcholine receptors suppresses hippocampal long-term potentiation in wild-type but not ApoE4 targeted replacement mice.
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Blocking the apoE/Aβ interaction ameliorates Aβ-related pathology in APOE ε2 and ε4 targeted replacement Alzheimer model mice.
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Blood pressure-associated polymorphism controls ARHGAP42 expression via serum response factor DNA binding.
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Bmp signaling regulates proximal-distal differentiation of endoderm in mouse lung development.
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Bmp4 and Fgf10 play opposing roles during lung bud morphogenesis.
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Bmp4 is essential for the formation of the vestibular apparatus that detects angular head movements.
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Body weight is not always a good predictor of longevity in mice.
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Bone Marrow Stress Decreases Osteogenic Progenitors.
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Bone marrow chimeras and c-fms conditional ablation (Mafia) mice reveal an essential role for resident myeloid cells in lipopolysaccharide/TLR4-induced corneal inflammation.
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Bone morphogenetic protein 4 mediates myocardial ischemic injury through JNK-dependent signaling pathway.
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Bone protection by inhibition of microRNA-182.
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Boosting cardiac contractility with genes.
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Brain radiation injury leads to a dose- and time-dependent recruitment of peripheral myeloid cells that depends on CCR2 signaling.
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Brain-derived neurotrophic factor but not vesicular zinc promotes TrkB activation within mossy fibers of mouse hippocampus in vivo.
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C-myc-induced apoptosis in polycystic kidney disease is Bcl-2 and p53 independent.
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C-terminal deletion of the atrophin-1 protein results in growth retardation but not neurodegeneration in mice.
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C3orf58, a novel paracrine protein, stimulates cardiomyocyte cell-cycle progression through the PI3K-AKT-CDK7 pathway.
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CCR2+ monocyte-derived dendritic cells and exudate macrophages produce influenza-induced pulmonary immune pathology and mortality.
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CD19 regulates B lymphocyte signaling thresholds critical for the development of B-1 lineage cells and autoimmunity.
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CD19-regulated signaling thresholds control peripheral tolerance and autoantibody production in B lymphocytes.
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CD69 gene is differentially regulated in T and B cells by evolutionarily conserved promoter-distal elements.
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CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+ T cells.
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CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis.
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CTLA-4-Mediated inhibition of early events of T cell proliferation.
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CX3CR1+ interstitial dendritic cells form a contiguous network throughout the entire kidney.
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CYLD inhibits tumorigenesis and metastasis by blocking JNK/AP1 signaling at multiple levels.
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CalDAG-GEFI down-regulation in the striatum as a neuroprotective change in Huntington's disease.
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Calcineurin activation causes retinal ganglion cell degeneration.
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Calcium-dependent regulation of cholecystokinin secretion and potassium currents in STC-1 cells.
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Calmodulin-induced early-onset diabetes in transgenic mice.
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Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium.
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Canonical Wnt signaling induces vascular endothelial dysfunction via p66Shc-regulated reactive oxygen species.
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Cardiac beta ARK1 inhibition prolongs survival and augments beta blocker therapy in a mouse model of severe heart failure.
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Cardiac function in genetically engineered mice with altered adrenergic receptor signaling.
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Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor.
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Cardiac hypertrophy and altered beta-adrenergic signaling in transgenic mice that express the amino terminus of beta-ARK1.
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Cardiac overexpression of a G(q) inhibitor blocks induction of extracellular signal-regulated kinase and c-Jun NH(2)-terminal kinase activity in in vivo pressure overload.
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Cardiac-specific expression of heme oxygenase-1 protects against ischemia and reperfusion injury in transgenic mice.
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Cardiac-specific overexpression of angiotensin II AT2 receptor causes attenuated response to AT1 receptor-mediated pressor and chronotropic effects.
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Cardiomyocyte-Specific Human Bcl2-Associated Anthanogene 3 P209L Expression Induces Mitochondrial Fragmentation, Bcl2-Associated Anthanogene 3 Haploinsufficiency, and Activates p38 Signaling.
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Cardioprotective and antiapoptotic effects of heme oxygenase-1 in the failing heart.
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Cardioprotective effects of 70-kDa heat shock protein in transgenic mice.
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Cardiovascular responses to the isoprostanes iPF(2alpha)-III and iPE(2)-III are mediated via the thromboxane A(2) receptor in vivo.
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Cartilage-specific RBPjκ-dependent and -independent Notch signals regulate cartilage and bone development.
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Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology.
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Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology.
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Catecholamine release and uptake in the mouse prefrontal cortex.
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Catecholaminergic cell lines from the brain and adrenal glands of tyrosine hydroxylase-SV40 T antigen transgenic mice.
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Cell death in age-related macular degeneration.
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Cell lineage mapping of taste bud cells and keratinocytes in the mouse tongue and soft palate.
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Cells of renin lineage are progenitors of podocytes and parietal epithelial cells in experimental glomerular disease
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Cellular and Circuitry Bases of Autism: Lessons Learned from the Temporospatial Manipulation of Autism Genes in the Brain.
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Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses.
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Cellular gene expression in papillomas of the choroid plexus from transgenic mice that express the simian virus 40 large T antigen.
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Cellular immune response to cryptic epitopes during therapeutic gene transfer.
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Cellular interactions implicated in the mechanism of photoreceptor degeneration in transgenic mice expressing a mutant rhodopsin gene.
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Central Mechanisms Mediating Thrombospondin-4-induced Pain States.
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Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells.
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Central tolerance regulates B cells reactive with Goodpasture antigen alpha3(IV)NC1 collagen.
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Challenges of comparative expression profiling studies of complex diseases: mouse models of myocardial hypertrophy. Focus on "Divergent transcriptional responses to independent genetic causes of cardiac hypertrophy".
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Characterization of NO and cytokine production in immune-activated microglia and peritoneal macrophages derived from a mouse model expressing the human NOS2 gene on a mouse NOS2 knockout background.
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Characterization of a CNS cell line, CAD, in which morphological differentiation is initiated by serum deprivation.
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Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice.
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Characterization of basal pseudopod-like processes in ileal and colonic PYY cells.
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Characterization of human CD7 transgenic mice.
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Characterization of murine BATF: a negative regulator of activator protein-1 activity in the thymus.
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Characterization of prostatic epithelial cell lines derived from transgenic adenocarcinoma of the mouse prostate (TRAMP) model.
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Chemical skin carcinogenesis is prevented in mice by the induced expression of a TGF-beta related transgene.
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Chronic axial compression of the mouse tail segment induces MRI bone marrow edema changes that correlate with increased marrow vasculature and cellularity.
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Chronic elevation of calmodulin in the ventricles of transgenic mice increases the autonomous activity of calmodulin-dependent protein kinase II, which regulates atrial natriuretic factor gene expression.
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Chronic fluoxetine increases extra-hippocampal neurogenesis in adult mice.
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Chronic lymphocytic leukemia and regulatory B cells share IL-10 competence and immunosuppressive function.
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Chronic oxidative stress promotes GADD34-mediated phosphorylation of the TAR DNA-binding protein TDP-43, a modification linked to neurodegeneration.
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Cic Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and Differentiation.
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Ciliated epithelial cell lifespan in the mouse trachea and lung.
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Circuit-selective striatal synaptic dysfunction in the Sapap3 knockout mouse model of obsessive-compulsive disorder.
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Cloning and characterization of developmental endothelial locus-1: an embryonic endothelial cell protein that binds the alphavbeta3 integrin receptor.
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Cold-induced brain edema in mice. Involvement of extracellular superoxide dismutase and nitric oxide.
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Combined deletion of Id2 and Id3 genes reveals multiple roles for E proteins in invariant NKT cell development and expansion.
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Comparing human pancreatic cell secretomes by in vitro aptamer selection identifies cyclophilin B as a candidate pancreatic cancer biomarker.
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Competitive displacement of phosphoinositide 3-kinase from beta-adrenergic receptor kinase-1 improves postinfarction adverse myocardial remodeling.
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Computed tomography imaging of primary lung cancer in mice using a liposomal-iodinated contrast agent.
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Conditional HIF-1 induction produces multistage neovascularization with stage-specific sensitivity to VEGFR inhibitors and myeloid cell independence.
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Conditional Macrophage Depletion Increases Inflammation and Does Not Inhibit the Development of Osteoarthritis in Obese Macrophage Fas-Induced Apoptosis-Transgenic Mice.
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Conditional clara cell ablation reveals a self-renewing progenitor function of pulmonary neuroendocrine cells.
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Conditional expression in corticothalamic efferents reveals a developmental role for nicotinic acetylcholine receptors in modulation of passive avoidance behavior.
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Conditional expression of SV40 T-antigen in mouse cardiomyocytes facilitates an inducible switch from proliferation to differentiation.
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Conditional expression of the mutant Ki-rasG12C allele results in formation of benign lung adenomas: development of a novel mouse lung tumor model.
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Conditional telomerase induction causes proliferation of hair follicle stem cells.
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Congenital brain serotonin deficiency leads to reduced ethanol sensitivity and increased ethanol consumption in mice.
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Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice.
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Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis.
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Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP.
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Control of myocardial contractile function by the level of beta-adrenergic receptor kinase 1 in gene-targeted mice.
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Convergence of G protein-coupled receptor and S-nitrosylation signaling determines the outcome to cardiac ischemic injury.
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Convergence of presenilin- and tau-mediated pathways on axonal trafficking and neuronal function.
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Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3.
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Copper Chelation Inhibits BRAFV600E-Driven Melanomagenesis and Counters Resistance to BRAFV600E and MEK1/2 Inhibitors.
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Coreceptor signal strength regulates positive selection but does not determine CD4/CD8 lineage choice in a physiologic in vivo model.
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Correlation between varying levels of PMP22 expression and the degree of demyelination and reduction in nerve conduction velocity in transgenic mice.
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Correlation of DNA fragmentation and chromatin condensation in apoptotic nuclei of the Ser 6 mouse retina.
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Cortical inhibition modified by embryonic neural precursors grafted into the postnatal brain.
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Cortical-amygdalar circuit dysfunction in a genetic mouse model of serotonin deficiency.
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Cortico-cortical projections in mouse visual cortex are functionally target specific.
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Costimulation of adenylyl cyclase and phospholipase C by a mutant alpha 1B-adrenergic receptor transgene promotes malignant transformation of thyroid follicular cells.
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Costimulator dependence of lymphokine secretion by naive and activated CD4+ T lymphocytes from TCR transgenic mice.
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Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes.
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Cp/Heph mutant mice have iron-induced neurodegeneration diminished by deferiprone.
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Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses.
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Critical role of TNF-α in cerebral aneurysm formation and progression to rupture.
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Critical role of the tumor suppressor tuberous sclerosis complex 1 in dendritic cell activation of CD4 T cells by promoting MHC class II expression via IRF4 and CIITA.
-
Cutting Edge: Localization of linker for activation of T cells to lipid rafts is not essential in T cell activation and development.
-
Cutting edge: ABIN-1 protects against psoriasis by restricting MyD88 signals in dendritic cells.
-
Cutting edge: Rapamycin augments pathogen-specific but not graft-reactive CD8+ T cell responses.
-
Cutting edge: TGF-beta-induced expression of Foxp3 in T cells is mediated through inactivation of ERK.
-
Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets.
-
Cutting edge: hierarchy of chemokine receptor and TCR signals regulating T cell migration and proliferation.
-
Cyclic Alopecia and Abnormal Epidermal Cornification in Zdhhc13-Deficient Mice Reveal the Importance of Palmitoylation in Hair and Skin Differentiation.
-
Cyclooxygenase-two (COX-2) modulates proliferation in aggressive fibromatosis (desmoid tumor).
-
Cystic fibrosis transmembrane conductance regulator activation is reduced in the small intestine of Na+/H+ exchanger 3 regulatory factor 1 (NHERF-1)- but Not NHERF-2-deficient mice.
-
Cytokine transcriptional events during helper T cell subset differentiation.
-
Cytotoxic-T-lymphocyte-mediated elimination of target cells transduced with engineered adeno-associated virus type 2 vector in vivo.
-
DNA regulatory sequences of the rat tyrosine hydroxylase gene direct correct catecholaminergic cell-type specificity of a human growth hormone reporter in the CNS of transgenic mice causing a dwarf phenotype.
-
DOK2 inhibits EGFR-mutated lung adenocarcinoma.
-
Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice.
-
Deconstructing B cell tolerance to basement membranes.
-
Decreased PPAR gamma expression compromises perigonadal-specific fat deposition and insulin sensitivity.
-
Decreased frequency and highly aberrant spectrum of ultraviolet-induced mutations in the hprt gene of mouse fibroblasts expressing antisense RNA to DNA polymerase zeta.
-
Decreased frequency of somatic hypermutation and impaired affinity maturation but intact germinal center formation in mice expressing antisense RNA to DNA polymerase zeta.
-
Decreased tumorigenesis in mice with a Kras point mutation at C118.
-
Dedifferentiation of committed epithelial cells into stem cells in vivo.
-
Defective beta-adrenergic receptor signaling precedes the development of dilated cardiomyopathy in transgenic mice with calsequestrin overexpression.
-
Defective glycolysis and calcium signaling underlie impaired insulin secretion in a transgenic mouse.
-
Defective survival and activation of thymocytes in transgenic mice expressing a catalytically inactive form of Ca2+/calmodulin-dependent protein kinase IV.
-
Deficiency of asparagine synthetase causes congenital microcephaly and a progressive form of encephalopathy.
-
Deletion of CD4 and CD8 coreceptors permits generation of alphabetaT cells that recognize antigens independently of the MHC.
-
Delivery of chemo-sensitizing siRNAs to HER2+-breast cancer cells using RNA aptamers.
-
Dendritic cell-expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice.
-
Dependence of germinal center B cells on expression of CD21/CD35 for survival.
-
Desensitization of the mouse thromboxane A2 receptor (TP) by G protein-coupled receptor kinases (Grks).
-
Desmoplakin: an unexpected regulator of microtubule organization in the epidermis.
-
Development of an ER action indicator mouse for the study of estrogens, selective ER modulators (SERMs), and Xenobiotics.
-
Development of mammary hyperplasia and neoplasia in MMTV-TGF alpha transgenic mice.
-
Developmental activation of the TCR alpha enhancer requires functional collaboration among proteins bound inside and outside the core enhancer.
-
Developmental regulation of VDJ recombination by the core fragment of the T cell receptor alpha enhancer.
-
Developmental regulation of alpha beta T cell antigen receptor expression results from differential stability of nascent TCR alpha proteins within the endoplasmic reticulum of immature and mature T cells.
-
Developmental stratification of the mammary epithelium occurs through symmetry-breaking vertical divisions of apically positioned luminal cells.
-
Dicistronic polioviruses as expression vectors for foreign genes.
-
Different immune cells mediate mechanical pain hypersensitivity in male and female mice.
-
Differential Requirements of TCR Signaling in Homeostatic Maintenance and Function of Dendritic Epidermal T Cells.
-
Differential regulation of primary and memory CD8 T cell immune responses by diacylglycerol kinases.
-
Dimerization and ubiquitin mediated recruitment of A20, a complex deubiquitinating enzyme.
-
Discordant on/off switching of gene expression in myocytes during cardiac hypertrophy in vivo.
-
Disease progression in iridocorneal angle tissues of BMP2-induced ocular hypertensive mice with optical coherence tomography.
-
Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice.
-
Disruption of Arp2/3 results in asymmetric structural plasticity of dendritic spines and progressive synaptic and behavioral abnormalities.
-
Disruption of ErbB receptor signaling in adult non-myelinating Schwann cells causes progressive sensory loss.
-
Disruption of Fgf13 causes synaptic excitatory-inhibitory imbalance and genetic epilepsy and febrile seizures plus.
-
Disruption of TrkB-mediated phospholipase Cgamma signaling inhibits limbic epileptogenesis.
-
Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis.
-
Disruption of wave-associated Rac GTPase-activating protein (Wrp) leads to abnormal adult neural progenitor migration associated with hydrocephalus.
-
Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver.
-
Distinct CD4+ helper T cells involved in primary and secondary responses to infection.
-
Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.
-
Distinct and overlapping sarcoma subtypes initiated from muscle stem and progenitor cells.
-
Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1.
-
Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm.
-
Distinctive patterns of hyperplasia in transgenic mice with mouse mammary tumor virus transforming growth factor-alpha. Characterization of mammary gland and skin proliferations.
-
Divergent pathways mediate the induction of ANF transgenes in neonatal and hypertrophic ventricular myocardium.
-
Diverse inflammatory responses in transgenic mouse models of Alzheimer's disease and the effect of immunotherapy on these responses.
-
Do germinal centers have a role in the generation of lymphomas?
-
Dopaminergic control of corticostriatal long-term synaptic depression in medium spiny neurons is mediated by cholinergic interneurons.
-
Down-regulation of the orphan nuclear receptor ROR gamma t is essential for T lymphocyte maturation.
-
Downregulation of NR3A-containing NMDARs is required for synapse maturation and memory consolidation.
-
Downregulation of T cell receptor expression by CD8(+) lymphocytes in kidney allografts.
-
Drd1a-tdTomato BAC transgenic mice for simultaneous visualization of medium spiny neurons in the direct and indirect pathways of the basal ganglia.
-
Dual control of dopamine synthesis and release by presynaptic and postsynaptic dopamine D2 receptors.
-
Dual stem loops within the poliovirus internal ribosomal entry site control neurovirulence.
-
Duration and intensity of NF-kappaB activity determine the severity of endotoxin-induced acute lung injury.
-
Dynamic and redundant regulation of LRRK2 and LRRK1 expression.
-
Dynamic antibody-binding properties in the pathogenesis of HIT.
-
Dynamically Timed Stimulation of Corticolimbic Circuitry Activates a Stress-Compensatory Pathway.
-
Dysregulation of dopamine transporters via dopamine D2 autoreceptors triggers anomalous dopamine efflux associated with attention-deficit hyperactivity disorder.
-
Dystonia and cerebellar atrophy in Cacna1a null mice lacking P/Q calcium channel activity.
-
E protein transcription factors are required for the development of CD4(+) lineage T cells.
-
E2A promotes the survival of precursor and mature B lymphocytes.
-
EAG2 potassium channel with evolutionarily conserved function as a brain tumor target.
-
Early growth response 1 and NF-ATc1 act in concert to promote thymocyte development beyond the beta-selection checkpoint.
-
Early induction of oxidative stress in mouse model of Alzheimer disease with reduced mitochondrial superoxide dismutase activity.
-
Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines.
-
Ectopic Expression of Retrotransposon-Derived PEG11/RTL1 Contributes to the Callipyge Muscular Hypertrophy.
-
Ectopic expression of DLK1 protein in skeletal muscle of padumnal heterozygotes causes the callipyge phenotype.
-
Ectopic overexpression of Sonic Hedgehog (Shh) induces stromal expansion and metaplasia in the adult murine pancreas.
-
Effect of flaxseed supplementation on prostatic carcinoma in transgenic mice.
-
Effect of receptor number on desensitization of the mouse thromboxane receptor.
-
Effects of the lpr mutation on elimination and inactivation of self-reactive B cells.
-
Efficacy of sunitinib and radiotherapy in genetically engineered mouse model of soft-tissue sarcoma.
-
Efficient cross-priming of antiviral CD8+ T cells by antigen donor cells is GRP94 independent.
-
Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice.
-
Electrical coupling mediates tunable low-frequency oscillations and resonance in the cerebellar Golgi cell network.
-
Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function.
-
Elevated PTH induces endothelial-to-chondrogenic transition in aortic endothelial cells.
-
Elevated beta-cell calmodulin produces a unique insulin secretory defect in transgenic mice.
-
Elevation of susceptibility to ozone-induced acute tracheobronchial injury in transgenic mice deficient in Clara cell secretory protein.
-
Elimination of GRK2 from cholinergic neurons reduces behavioral sensitivity to muscarinic receptor activation.
-
Elucidation of The Behavioral Program and Neuronal Network Encoded by Dorsal Raphe Serotonergic Neurons.
-
Emergence of a seizure phenotype in aged apolipoprotein epsilon 4 targeted replacement mice.
-
Emergence of anxiety-like behaviours in depressive-like Cpe(fat/fat) mice.
-
Enabling hyperpolarized (129) Xe MR spectroscopy and imaging of pulmonary gas transfer to the red blood cells in transgenic mice expressing human hemoglobin.
-
Endogenous apolipoprotein E suppresses LPS-stimulated microglial nitric oxide production.
-
Endoglin promotes transforming growth factor beta-mediated Smad 1/5/8 signaling and inhibits endothelial cell migration through its association with GIPC.
-
Endostatin inhibits the vascular endothelial growth factor-induced mobilization of endothelial progenitor cells.
-
Endothelial Bmp4 is induced during arterial remodeling: effects on smooth muscle cell migration and proliferation.
-
Endothelial and steroidogenic cell migration are regulated by WNT4 in the developing mammalian gonad.
-
Endothelial antigen presentation: stimulation of previously activated but not naïve TCR-transgenic mouse T cells.
-
Enforced expression of FGF-7 promotes epithelial hyperplasia whereas a dominant negative FGFR2iiib promotes the emergence of neuroendocrine phenotype in prostate glands of transgenic mice.
-
Enhanced GLUT4-Dependent Glucose Transport Relieves Nutrient Stress in Obese Mice Through Changes in Lipid and Amino Acid Metabolism.
-
Enhanced Glucose Control Following Vertical Sleeve Gastrectomy Does Not Require a β-Cell Glucagon-Like Peptide 1 Receptor.
-
Enhanced capillary amyloid angiopathy-associated pathology in Tg-SwDI mice with deleted nitric oxide synthase 2.
-
Enhanced cardiac function in transgenic mice expressing a Ca(2+)-stimulated adenylyl cyclase.
-
Enhanced growth of small bowel in transgenic mice expressing human insulin-like growth factor I.
-
Enhanced growth of small bowel in transgenic mice overexpressing bovine growth hormone.
-
Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor.
-
Enhanced myocardial relaxation in vivo in transgenic mice overexpressing the beta2-adrenergic receptor is associated with reduced phospholamban protein.
-
Enhanced postischemic functional recovery in CYP2J2 transgenic hearts involves mitochondrial ATP-sensitive K+ channels and p42/p44 MAPK pathway.
-
Enhancement of dopaminergic properties and protection mediated by neuronal activation of Ras in mouse ventral mesencephalic neurones.
-
Enhancer analysis of the mouse HNF-3 beta gene: regulatory elements for node/notochord and floor plate are independent and consist of multiple sub-elements.
-
Enhancer control of local accessibility to V(D)J recombinase.
-
Epidermal growth factor receptor trans-activation mediates the tonic and fibrogenic effects of endothelin in the aortic wall of transgenic mice.
-
Epigenetic instability of cytokine and transcription factor gene loci underlies plasticity of the T helper 17 cell lineage.
-
Epigenetic silencing of Kruppel like factor-3 increases expression of pro-metastatic miR-182.
-
Epithalon decelerates aging and suppresses development of breast adenocarcinomas in transgenic her-2/neu mice.
-
Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis.
-
Epithelial stem/progenitor cells in lung postnatal growth, maintenance, and repair.
-
Erythroid-specific expression of human CD59 and transfer to vascular endothelial cells.
-
Erythropoietin activates mitochondrial biogenesis and couples red cell mass to mitochondrial mass in the heart.
-
Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function.
-
Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock.
-
Establishment and characterization of conditionally immortalized cells from the mouse urogenital ridge.
-
Estradiol enhances long term potentiation in hippocampal slices from aged apoE4-TR mice.
-
Ethylenecarbodiimide-fixed donor splenocyte infusions differentially target direct and indirect pathways of allorecognition for induction of transplant tolerance.
-
Ethylenecarbodiimide-treated splenocytes carrying male CD4 epitopes confer histocompatibility Y chromosome antigen transplant protection by inhibiting CD154 upregulation.
-
Evidence for the involvement of the Gli gene family in embryonic mouse lung development.
-
Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis.
-
Evidence that SOX2 overexpression is oncogenic in the lung.
-
Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway.
-
Expansion of the Parkinson disease-associated SNCA-Rep1 allele upregulates human alpha-synuclein in transgenic mouse brain.
-
Experimental autoimmune encephalomyelitis in mice lacking glial fibrillary acidic protein is characterized by a more severe clinical course and an infiltrative central nervous system lesion.
-
Exploring the role of the beta-adrenergic receptor kinase in cardiac disease using gene-targeted mice.
-
Exploring type I angiotensin (AT1) receptor functions through gene targeting.
-
Exposure to a youthful circulaton rejuvenates bone repair through modulation of β-catenin.
-
Expression and functional analysis of Gm114, a putative mammalian ortholog of Drosophila bam.
-
Expression and modification of Hox 2.1 protein in mouse embryos.
-
Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis.
-
Expression of Sry, the mouse sex determining gene.
-
Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice.
-
Expression of full-length and truncated dystrophin mini-genes in transgenic mdx mice.
-
Expression of functional estrogen receptor beta in locus coeruleus-derived Cath.a cells.
-
Expression of glucokinase in cultured human muscle cells confers insulin-independent and glucose concentration-dependent increases in glucose disposal and storage.
-
Expression of mitofusin 2(R94Q) in a transgenic mouse leads to Charcot-Marie-Tooth neuropathy type 2A.
-
Expression of the human poliovirus receptor/CD155 gene during development of the central nervous system: implications for the pathogenesis of poliomyelitis.
-
Expression of the human poliovirus receptor/CD155 gene is activated by sonic hedgehog.
-
Expression of tumor necrosis factor receptor-1 in arterial wall cells promotes atherosclerosis.
-
Expression of v-Ha-ras driven by the calcitonin/calcitonin gene-related peptide promoter: a novel transgenic murine model for medullary thyroid carcinoma.
-
Extracellular superoxide dismutase in the airways of transgenic mice reduces inflammation and attenuates lung toxicity following hyperoxia.
-
Extracellular superoxide dismutase overexpression improves behavioral outcome from closed head injury in the mouse.
-
Extracellular superoxide dismutase overexpression protects against aging-induced cognitive impairment in mice.
-
Extracellular superoxide dismutase protects lung development in hyperoxia-exposed newborn mice.
-
Extracellular superoxide dismutase, nitric oxide, and central nervous system O2 toxicity.
-
Failure of ventral body wall closure in mouse embryos lacking a procollagen C-proteinase encoded by Bmp1, a mammalian gene related to Drosophila tolloid.
-
Faithful expression of GFP from the PLCbeta2 promoter in a functional class of taste receptor cells.
-
Fasnall, a Selective FASN Inhibitor, Shows Potent Anti-tumor Activity in the MMTV-Neu Model of HER2(+) Breast Cancer.
-
Fate mapping reveals that microglia and recruited monocyte-derived macrophages are definitively distinguishable by phenotype in the retina.
-
Fate-mapping evidence that hepatic stellate cells are epithelial progenitors in adult mouse livers.
-
Feedback in the brainstem: an excitatory disynaptic pathway for control of whisking.
-
Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung.
-
Fibroblast growth factor receptor 2 regulates proliferation and Sertoli differentiation during male sex determination.
-
Flanking nuclear matrix attachment regions synergize with the T cell receptor delta enhancer to promote V(D)J recombination.
-
Fluorescence-based alternative splicing reporters for the study of epithelial plasticity in vivo.
-
Four-dimensional analysis of vascularization during primary development of an organ, the gonad.
-
FoxO-dependent regulation of diacylglycerol kinase α gene expression.
-
Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression.
-
Full genetic rescue of adenosine deaminase-deficient mice through introduction of the human gene.
-
Functional analysis of myocardial performance in murine hearts overexpressing the human beta 2-adrenergic receptor.
-
Functional analysis of two distinct bronchiolar progenitors during lung injury and repair.
-
Functional characteristics and survival requirements of memory CD4+ T lymphocytes in vivo.
-
Functional comparison of RGS9 splice isoforms in a living cell.
-
Functional consequences of altering myocardial adrenergic receptor signaling.
-
Functional genomics of the beta-cell: short-chain 3-hydroxyacyl-coenzyme A dehydrogenase regulates insulin secretion independent of K+ currents.
-
Functional hyperdopaminergia in dopamine transporter knock-out mice.
-
Functionally rodless mice: transgenic models for the investigation of cone function in retinal disease and therapy.
-
Functions of MutLalpha, replication protein A (RPA), and HMGB1 in 5'-directed mismatch repair.
-
G protein-coupled receptor internalization signaling is required for cardioprotection in ischemic preconditioning.
-
G protein-coupled receptor kinase 5 regulates airway responses induced by muscarinic receptor activation.
-
G(s)alpha deficiency in adipose tissue leads to a lean phenotype with divergent effects on cold tolerance and diet-induced thermogenesis.
-
G2019S-LRRK2 Expression Augments α-Synuclein Sequestration into Inclusions in Neurons.
-
GUCY2C opposes systemic genotoxic tumorigenesis by regulating AKT-dependent intestinal barrier integrity.
-
Galphaq-dependent signaling cascades stimulate water-seeking behavior.
-
Gene expression phenotypic models that predict the activity of oncogenic pathways.
-
Gene targeting in physiological investigations: studies of the renin-angiotensin system.
-
Gene therapy of cystic fibrosis lung disease using E1 deleted adenoviruses: a phase I trial.
-
Gene therapy to manipulate effector T cell trafficking to tumors for immunotherapy.
-
Generation of a loxP flanked bmp4loxP-lacZ allele marked by conditional lacZ expression.
-
Generation of primary tumors with Flp recombinase in FRT-flanked p53 mice.
-
Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress.
-
Genetic deletion of A2A adenosine receptors in the striatum selectively impairs habit formation.
-
Genetic deletion of receptor for hyaluronan-mediated motility (Rhamm) attenuates the formation of aggressive fibromatosis (desmoid tumor).
-
Genetic elimination of α3(IV) collagen fails to rescue anti-collagen B cells.
-
Genetic manipulation of the renin-angiotensin system.
-
Genetic modifier loci affecting survival and cardiac function in murine dilated cardiomyopathy.
-
Genetic variation in SP-A2 leads to differential binding to Mycoplasma pneumoniae membranes and regulation of host responses.
-
Genome-wide analysis of miRNA signature in the APPswe/PS1ΔE9 mouse model of alzheimer's disease.
-
Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma.
-
Gli Transcription Factors Mediate the Oncogenic Transformation of Prostate Basal Cells Induced by a Kras-Androgen Receptor Axis.
-
Glimpse of natural selection of long-lived T-cell clones in healthy life.
-
Glioma stem cell proliferation and tumor growth are promoted by nitric oxide synthase-2.
-
Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways.
-
Gq signaling causes glomerular injury by activating TRPC6.
-
Gq-dependent signaling upregulates COX2 in glomerular podocytes.
-
Gradients of transgene expression directed by the human myoglobin promoter in the developing mouse heart.
-
Graft-extrinsic cells predominate in vein graft arterialization.
-
Growth factors regulate beta-catenin-mediated TCF-dependent transcriptional activation in fibroblasts during the proliferative phase of wound healing.
-
Growth failure and AIDS-like cachexia syndrome in HIV-1 transgenic mice.
-
Growth phenotypes and biosafety profiles in poliovirus-receptor transgenic mice of recombinant oncolytic polio/human rhinoviruses.
-
Gustatory effects of capsaicin that are independent of TRPV1 receptors.
-
Gut barrier dysfunction in the Apc(Min/+) mouse model of colon cancer cachexia.
-
Gαi/o-coupled receptor signaling restricts pancreatic β-cell expansion.
-
HIV-1 Nef induces dedifferentiation of podocytes in vivo: a characteristic feature of HIVAN.
-
HIV-1 Nef induces proliferation and anchorage-independent growth in podocytes.
-
HIV-1 Vpr activates the DNA damage response in renal tubule epithelial cells.
-
HIV-1 induces renal epithelial dedifferentiation in a transgenic model of HIV-associated nephropathy.
-
HIV-1 infection initiates an inflammatory cascade in human renal tubular epithelial cells.
-
HKDC1 Is a Novel Hexokinase Involved in Whole-Body Glucose Use.
-
HNF-3 beta as a regulator of floor plate development.
-
Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons.
-
Heart and lung disease in engineered mice.
-
Hedgehog regulates yes-associated protein 1 in regenerating mouse liver.
-
Hedgehog signaling activates a positive feedback mechanism involving insulin-like growth factors to induce osteoblast differentiation.
-
Hedgehog signaling blockade delays hepatocarcinogenesis induced by hepatitis B virus X protein.
-
Hedgehog signalling regulates liver sinusoidal endothelial cell capillarisation.
-
Heme oxygenase-1 gene ablation or expression modulates cisplatin-induced renal tubular apoptosis.
-
Heme-oxygenase-1-induced protection against hypoxia/reoxygenation is dependent on biliverdin reductase and its interaction with PI3K/Akt pathway.
-
Heparin-induced thrombocytopenia/thrombosis in a transgenic mouse model requires human platelet factor 4 and platelet activation through FcgammaRIIA.
-
Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression.
-
Hepatic mTORC1 Opposes Impaired Insulin Action to Control Mitochondrial Metabolism in Obesity.
-
Hepatic stellate cells undermine the allostimulatory function of liver myeloid dendritic cells via STAT3-dependent induction of IDO.
-
Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice.
-
High levels of human gamma-globin gene expression in adult mice carrying a transgene of deletion-type hereditary persistence of fetal hemoglobin.
-
High-fat/high-cholesterol diet promotes a S1P receptor-mediated antiapoptotic activity for VLDL.
-
High-resolution magnetic resonance histology of the embryonic and neonatal mouse: a 4D atlas and morphologic database.
-
High-speed mapping of synaptic connectivity using photostimulation in Channelrhodopsin-2 transgenic mice.
-
High-throughput identification and dendritic cell-based functional validation of MHC class I-restricted Mycobacterium tuberculosis epitopes.
-
Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice.
-
Human apoE targeted replacement mouse lines: h-apoE4 and h-apoE3 mice differ on spatial memory performance and avoidance behavior.
-
Human apoE4-targeted replacement mice display synaptic deficits in the absence of neuropathology.
-
Human apolipoprotein B transgenic mice generated with 207- and 145-kilobase pair bacterial artificial chromosomes. Evidence that a distant 5'-element confers appropriate transgene expression in the intestine.
-
Human apolipoprotein E redistributes fibrillar amyloid deposition in Tg-SwDI mice.
-
Human apolipoprotein E2 promotes parenchymal amyloid deposition and neuronal loss in vasculotropic mutant amyloid-β protein Tg-SwDI mice.
-
Human apolipoprotein E2, E3, and E4 isoform-specific transgenic mice: human-like pattern of glial and neuronal immunoreactivity in central nervous system not observed in wild-type mice.
-
Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model.
-
Human apolipoprotein E4 targeted replacement mice show increased prevalence of intracerebral hemorrhage associated with vascular amyloid deposition.
-
Human apolipoprotein E4 worsens acute axonal pathology but not amyloid-β immunoreactivity after traumatic brain injury in 3xTG-AD mice.
-
Human cystic fibrosis transmembrane conductance regulator directed to respiratory epithelial cells of transgenic mice.
-
Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development.
-
Human-chimpanzee differences in a FZD8 enhancer alter cell-cycle dynamics in the developing neocortex.
-
Humoral autoimmunity in mice overexpressing B cell surface CD19: vital role for MHC class II.
-
Humoral autoimmunity to basement membrane antigens is regulated in C57BL/6 and MRL/MpJ mice transgenic for anti-laminin Ig receptors.
-
Huntingtin is required for normal excitatory synapse development in cortical and striatal circuits.
-
Hybrid transgenic mice reveal in vivo specificity of G protein-coupled receptor kinases in the heart.
-
Hydrogen peroxide promotes aging-related platelet hyperactivation and thrombosis.
-
Hyperactive Wnt signaling changes the developmental potential of embryonic lung endoderm.
-
Hyperactivity and cortical disinhibition in mice with restricted expression of mutant huntingtin to parvalbumin-positive cells.
-
Hyperdopaminergia and NMDA receptor hypofunction disrupt neural phase signaling.
-
Hypertension and albuminuria in chronic kidney disease mapped to a mouse chromosome 11 locus.
-
Hypoxia reprograms calcium signaling and regulates myoglobin expression.
-
Hypoxia-dependent modification of collagen networks promotes sarcoma metastasis.
-
IFN-gamma dictates allograft fate via opposing effects on the graft and on recipient CD8 T cell responses.
-
IL-10 induces regulatory T cell apoptosis by up-regulation of the membrane form of TNF-alpha.
-
IL-15 regulates homeostasis and terminal maturation of NKT cells.
-
IL-21 deficiency influences CD8 T cell quality and recall responses following an acute viral infection.
-
IL-4-STAT6 signal transduction-dependent induction of the clinical phase of Sjögren's syndrome-like disease of the nonobese diabetic mouse.
-
IL-6/STAT3 promotes regeneration of airway ciliated cells from basal stem cells.
-
IL-7 enhances the survival and maintains the size of naive T cells.
-
IL-7 is essential for homeostatic control of T cell metabolism in vivo.
-
IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation.
-
Identification of an inhibitory circuit that regulates cerebellar Golgi cell activity.
-
Identification of myeloid cell subsets in murine lungs using flow cytometry.
-
Identification of p18 INK4c as a tumor suppressor gene in glioblastoma multiforme.
-
Imaging primary lung cancers in mice to study radiation biology.
-
Imaging synaptic inhibition in transgenic mice expressing the chloride indicator, Clomeleon.
-
Imaging synaptic inhibition throughout the brain via genetically targeted Clomeleon.
-
Imaging the alternative silencing of FGFR2 exon IIIb in vivo.
-
Immortalized hypothalamic gonadotropin-releasing hormone neurons.
-
Immortalized hypothalamic luteinizing hormone-releasing hormone (LHRH) neurons: a new tool for dissecting the molecular and cellular basis of LHRH physiology.
-
Immune responses to viral antigens versus transgene product in the elimination of recombinant adenovirus-infected hepatocytes in vivo.
-
Immunity-related GTPase M (IRGM) proteins influence the localization of guanylate-binding protein 2 (GBP2) by modulating macroautophagy.
-
Immunology of gene therapy with adenoviral vectors in mouse skeletal muscle.
-
Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues.
-
Immunotherapy using unconjugated CD19 monoclonal antibodies in animal models for B lymphocyte malignancies and autoimmune disease.
-
Immunotherapy, vascular pathology, and microhemorrhages in transgenic mice.
-
Impact of the genetic background of transgenic mice upon the formation and timing of choroid plexus papillomas.
-
Impaired cytoskeletal organization and membrane integrity in lens fibers of a Rho GTPase functional knockout transgenic mouse.
-
Impaired limbic gamma oscillatory synchrony during anxiety-related behavior in a genetic mouse model of bipolar mania.
-
Impaired thermoregulation and beneficial effects of thermoneutrality in the 3×Tg-AD model of Alzheimer's disease.
-
Impairment of kindling development in phospholipase Cγ1 heterozygous mice.
-
Improved adenoviral vectors for gene therapy of Duchenne muscular dystrophy.
-
Improving Mycobacterium bovis bacillus Calmette-Guèrin as a vaccine delivery vector for viral antigens by incorporation of glycolipid activators of NKT cells.
-
In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability.
-
In vitro electrophoresis and in vivo electrophysiology of peripheral nerve using DC field stimulation.
-
In vivo and in vitro analyses of amygdalar function reveal a role for copper.
-
In vivo inhibition of elevated myocardial beta-adrenergic receptor kinase activity in hybrid transgenic mice restores normal beta-adrenergic signaling and function.
-
In vivo luminescence imaging of NF-κB activity and serum cytokine levels predict pain sensitivities in a rodent model of osteoarthritis.
-
In vivo transfer of GPI-linked complement restriction factors from erythrocytes to the endothelium.
-
In-vivo impaired T helper 1 cell development in submandibular lymph nodes due to IL-12 deficiency following antigen injection into the anterior chamber of the eye.
-
Inactivated vaccines based on alternatives to wild-type seed virus.
-
Increased Metabotropic Glutamate Receptor 5 Signaling Underlies Obsessive-Compulsive Disorder-like Behavioral and Striatal Circuit Abnormalities in Mice.
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Increased alpha2 subunit-associated AMPK activity and PRKAG2 cardiomyopathy.
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Increased amphetamine-induced hyperactivity and reward in mice overexpressing the dopamine transporter.
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Increased expression of the dopamine transporter leads to loss of dopamine neurons, oxidative stress and l-DOPA reversible motor deficits.
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Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle.
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Increased myocardial contractility and enhanced exercise function in transgenic mice overexpressing either adenylyl cyclase 5 or 8.
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Increased skin carcinogenesis in caspase-activated DNase knockout mice.
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Increased vascular smooth muscle contractility in TRPC6-/- mice.
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Increases in cortical glutamate concentrations in transgenic amyotrophic lateral sclerosis mice are attenuated by creatine supplementation.
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Increasing vaccine potency through exosome antigen targeting.
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Inducible and conditional deletion of extracellular signal-regulated kinase 5 disrupts adult hippocampal neurogenesis.
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Induction of type I IFN is required for overcoming tumor-specific T-cell tolerance after stem cell transplantation.
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Induction of tyrosine hydroxylase in the locus coeruleus of transgenic mice in response to stress or nicotine treatment: lack of activation of tyrosine hydroxylase promoter activity.
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Induction of tyrosine hydroxylase protein and a transgene containing tyrosine hydroxylase 5' flanking sequences by stress in mouse adrenal gland.
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Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5.
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Inflammatory Th1 and Th17 in the Intestine Are Each Driven by Functionally Specialized Dendritic Cells with Distinct Requirements for MyD88.
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Influence of CD4 T cells and the source of major histocompatibility complex class II-restricted peptides on cytotoxic T-cell priming by dendritic cells.
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Influence of terminal nerve branch size on motor neuron regeneration accuracy.
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Inhibition of Bmp signaling affects growth and differentiation in the anagen hair follicle.
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Inhibition of Na+/H+ exchange stimulates CCK secretion in STC-1 cells.
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Inhibition of Neu-induced mammary carcinogenesis in transgenic mice expressing ERΔ3, a dominant negative estrogen receptor α variant.
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Inhibition of betaARK1 restores impaired biochemical beta-adrenergic receptor responsiveness but does not rescue CREB(A133) induced cardiomyopathy.
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Inhibition of mammary duct development but not alveolar outgrowth during pregnancy in transgenic mice expressing active TGF-beta 1.
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Inhibition of the NFAT pathway alleviates amyloid β neurotoxicity in a mouse model of Alzheimer's disease.
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Inhibition of vascular endothelial growth factor A and hypoxia-inducible factor 1α maximizes the effects of radiation in sarcoma mouse models through destruction of tumor vasculature.
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Initial observations of key features of age-related macular degeneration in APOE targeted replacement mice.
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Initial sequencing and comparative analysis of the mouse genome.
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Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations.
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Initiation of allelic exclusion by stochastic interaction of Tcrb alleles with repressive nuclear compartments.
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Insulin in aging and cancer: antidiabetic drug Diabenol as geroprotector and anticarcinogen.
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Insulin reverses the high-fat diet-induced increase in brain Aβ and improves memory in an animal model of Alzheimer disease.
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Integrated Regulation of Hepatic Lipid and Glucose Metabolism by Adipose Triacylglycerol Lipase and FoxO Proteins.
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Integrating factor analysis and a transgenic mouse model to reveal a peripheral blood predictor of breast tumors.
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Integrin beta 1 regulates phagosome maturation in macrophages through Rac expression.
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Integrin functions play a key role in the differentiation of thymocytes in vivo.
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Interactions of peptide amidation and copper: novel biomarkers and mechanisms of neural dysfunction.
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Interferon-β therapy against EAE is effective only when development of the disease depends on the NLRP3 inflammasome.
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Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction.
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Intersectional Cre driver lines generated using split-intein mediated split-Cre reconstitution.
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Intrauterine telemetry to measure mouse contractile pressure in vivo.
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Intravital imaging of Ca(2+) signals in lymphocytes of Ca(2+) biosensor transgenic mice: indication of autoimmune diseases before the pathological onset.
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Intrinsic IL-21 signaling is critical for CD8 T cell survival and memory formation in response to vaccinia viral infection.
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Intrinsic and induced regulation of the age-associated onset of spontaneous experimental autoimmune encephalomyelitis.
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Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis.
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Iron is essential for neuron development and memory function in mouse hippocampus.
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Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide.
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JunB promotes Th17 cell identity and restrains alternative CD4+ T-cell programs during inflammation.
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Kappa editing rescues autoreactive B cells destined for deletion in mice transgenic for a dual specific anti-laminin Ig.
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Knock-in mouse model of alternating hemiplegia of childhood: behavioral and electrophysiologic characterization.
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L-selectin is not required for T cell-mediated autoimmune diabetes.
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LAT-mediated signaling in CD4+CD25+ regulatory T cell development.
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LFA-1 blockade induces effector and regulatory T-cell enrichment in lymph nodes and synergizes with CTLA-4Ig to inhibit effector function.
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Level of beta-adrenergic receptor kinase 1 inhibition determines degree of cardiac dysfunction after chronic pressure overload-induced heart failure.
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Ligand-induced overexpression of a constitutively active beta2-adrenergic receptor: pharmacological creation of a phenotype in transgenic mice.
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Ligand-specific selection of MHC class II-restricted thymocytes in fetal thymic organ culture.
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Limbic epilepsy in transgenic mice carrying a Ca2+/calmodulin-dependent kinase II alpha-subunit mutation.
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Limited regional cerebellar dysfunction induces focal dystonia in mice.
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Linker for activation of B cells: a functional equivalent of a mutant linker for activation of T cells deficient in phospholipase C-gamma1 binding.
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Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer.
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Lithium ameliorates nucleus accumbens phase-signaling dysfunction in a genetic mouse model of mania.
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Live imaging of mitosis in the developing mouse embryonic cortex.
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Liver X receptors alpha and beta regulate renin expression in vivo.
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Localization of brain-derived neurotrophic factor to distinct terminals of mossy fiber axons implies regulation of both excitation and feedforward inhibition of CA3 pyramidal cells.
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Long-term exposure of chemokine CXCL10 causes bronchiolitis-like inflammation.
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Long-term mutagenicity studies with chloroform and dimethylnitrosamine in female lacI transgenic B6C3F1 mice.
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Long-term survival of influenza virus infected club cells drives immunopathology.
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Loss of basal cells precedes bronchiolitis obliterans-like pathological changes in a murine model of chlorine gas inhalation.
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Loss of p53 in benzene-induced thymic lymphomas in p53+/- mice: evidence of chromosomal recombination.
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Loss of tau elicits axonal degeneration in a mouse model of Alzheimer's disease.
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Lung EC-SOD overexpression attenuates hypoxic induction of Egr-1 and chronic hypoxic pulmonary vascular remodeling.
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Lung development and repair: contribution of the ciliated lineage.
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Lung-specific overexpression of CC chemokine ligand (CCL) 2 enhances the host defense to Streptococcus pneumoniae infection in mice: role of the CCL2-CCR2 axis.
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Lupus-specific antiribonucleoprotein B cell tolerance in nonautoimmune mice is maintained by differentiation to B-1 and governed by B cell receptor signaling thresholds.
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Ly6Chi monocytes regulate T cell responses in viral hepatitis.
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MED13-dependent signaling from the heart confers leanness by enhancing metabolism in adipose tissue and liver.
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MEF2 responds to multiple calcium-regulated signals in the control of skeletal muscle fiber type.
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MEK1/2 inhibitors reverse acute vascular occlusion in mouse models of sickle cell disease.
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MEKK3 is essential for lymphopenia-induced T cell proliferation and survival.
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MMTV-PyMT and Derived Met-1 Mouse Mammary Tumor Cells as Models for Studying the Role of the Androgen Receptor in Triple-Negative Breast Cancer Progression.
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Macrophage IL-10 blocks CD8+ T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells.
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Macrophages and cardiac fibroblasts are the main producers of eotaxins and regulate eosinophil trafficking to the heart.
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Macrophages promote osteoblastic differentiation in-vivo: implications in fracture repair and bone homeostasis.
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Manganese superoxide dismutase-mediated inside-out signaling in HaCaT human keratinocytes and SKH-1 mouse skin.
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Marked enhancement in myocardial function resulting from overexpression of a human beta-adrenergic receptor gene.
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Marked induction of the helix-loop-helix protein Id3 promotes the gammadelta T cell fate and renders their functional maturation Notch independent.
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Marked regional differences of brain human apolipoprotein E expression in targeted replacement mice.
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Massive normalization of olfactory bulb output in mice with a 'monoclonal nose'.
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Mast cells are critical for protection against peptic ulcers induced by the NSAID piroxicam.
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Mast cells in tumor microenvironment promotes the in vivo growth of pancreatic ductal adenocarcinoma.
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Maternal Loss of Ube3a Impairs Experience-Driven Dendritic Spine Maintenance in the Developing Visual Cortex.
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MeCP2 enforces Foxp3 expression to promote regulatory T cells' resilience to inflammation.
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MeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulants.
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MeCP2 phosphorylation limits psychostimulant-induced behavioral and neuronal plasticity.
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Mechanism of beta-adrenergic receptor desensitization in cardiac hypertrophy is increased beta-adrenergic receptor kinase.
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Mechanisms of the proteinuria induced by Rho GTPases.
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Meiotic germ cells antagonize mesonephric cell migration and testis cord formation in mouse gonads.
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Melanoma-Derived Wnt5a Promotes Local Dendritic-Cell Expression of IDO and Immunotolerance: Opportunities for Pharmacologic Enhancement of Immunotherapy.
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Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease.
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Membrane attachment is key to protecting transducin GTPase-activating complex from intracellular proteolysis in photoreceptors.
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Memory decline of aging reduced by extracellular superoxide dismutase overexpression.
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Metabolic Catastrophe in Mice Lacking Transferrin Receptor in Muscle.
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Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells.
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Metallothionein abrogates GTP cyclohydrolase I inhibition-induced cardiac contractile and morphological defects: role of mitochondrial biogenesis.
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Metallothionein alleviates cardiac dysfunction in streptozotocin-induced diabetes: role of Ca2+ cycling proteins, NADPH oxidase, poly(ADP-Ribose) polymerase and myosin heavy chain isozyme.
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Metallothionein alleviates glutathione depletion-induced oxidative cardiomyopathy in murine hearts.
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Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis.
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Methamphetamine toxicity is attenuated in mice that overexpress human manganese superoxide dismutase.
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Method for single illumination source combined optical coherence tomography and fluorescence imaging of fluorescently labeled ocular structures in transgenic mice.
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Methods to generate genetically engineered mouse models of soft tissue sarcoma.
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Methylphenidate amplifies the potency and reinforcing effects of amphetamines by increasing dopamine transporter expression.
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Mice deficient for the vesicular acetylcholine transporter are myasthenic and have deficits in object and social recognition.
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Mice overexpressing extracellular superoxide dismutase have increased resistance to focal cerebral ischemia.
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Mice overexpressing extracellular superoxide dismutase have increased resistance to global cerebral ischemia.
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Mice that overexpress CC chemokine ligand 2 in their lungs show increased protective immunity to infection with Mycobacterium bovis bacille Calmette-Guérin.
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Mice transgenic for a vasopressin-SV40 hybrid oncogene develop tumors of the endocrine pancreas and the anterior pituitary. A possible model for human multiple endocrine neoplasia type 1.
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Mice with a "monoclonal nose": perturbations in an olfactory map impair odor discrimination.
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Mice with chronically increased circulating ghrelin develop age-related glucose intolerance.
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Micro-computed tomography in murine models of cerebral cavernous malformations as a paradigm for brain disease.
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MicroRNA-182 drives metastasis of primary sarcomas by targeting multiple genes.
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MicroRNA-23a Curbs Necrosis during Early T Cell Activation by Enforcing Intracellular Reactive Oxygen Species Equilibrium.
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MicroRNA-mediated in vitro and in vivo direct reprogramming of cardiac fibroblasts to cardiomyocytes.
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Microglial function in human APOE3 and APOE4 transgenic mice: altered arginine transport.
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Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks.
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Migration of mesonephric cells into the mammalian gonad depends on Sry.
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Mitochondrial biogenesis restores oxidative metabolism during Staphylococcus aureus sepsis.
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Mnk1 and 2 are dispensable for T cell development and activation but important for the pathogenesis of experimental autoimmune encephalomyelitis.
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Model systems for the study of heart development and disease. Cardiac neural crest and conotruncal malformations.
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Modeling infectious disease in mice: co-adaptation and the role of host-specific IFNgamma responses.
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Modular flexibility of dystrophin: implications for gene therapy of Duchenne muscular dystrophy.
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Modular nanotransporters: a multipurpose in vivo working platform for targeted drug delivery.
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Modular utilization of distal cis-regulatory elements controls Ifng gene expression in T cells activated by distinct stimuli.
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Molecular and phenotypic characterization of a new mouse insertional mutation that causes a defect in the distal vertebrae of the spine.
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Molecular manipulations of extracellular superoxide dismutase: functional importance for learning.
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Molecular phenotype of simian virus 40 large T antigen-induced primitive neuroectodermal tumors in four different lines of transgenic mice.
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Molecular staging of epithelial maturation using secretory cell-specific genes as markers.
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Monoclonal antibody blockade of IL-2 receptor α during lymphopenia selectively depletes regulatory T cells in mice and humans.
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Monocyte chemoattractant protein-1 is sufficient for the chemotaxis of monocytes and lymphocytes in transgenic mice but requires an additional stimulus for inflammatory activation.
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Mortalin is regulated by APOE in hippocampus of AD patients and by human APOE in TR mice.
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Mouse embryonic germ (EG) cell lines: transmission through the germline and differences in the methylation imprint of insulin-like growth factor 2 receptor (Igf2r) gene compared with embryonic stem (ES) cell lines.
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Mouse germ cell clusters form by aggregation as well as clonal divisions.
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Mouse model of rare TOR1A variant found in sporadic focal dystonia impairs domains affected in DYT1 dystonia patients and animal models.
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Mouse models for studying genetic influences on factors determining smoking cessation success in humans.
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Mouse models of MYH9-related disease: mutations in nonmuscle myosin II-A.
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Mouse models of diabetic nephropathy.
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Mouse models of retinal ganglion cell death and glaucoma.
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Mouse neuropathogenic poliovirus strains cause damage in the central nervous system distinct from poliomyelitis.
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Multiple roles for Sox2 in the developing and adult mouse trachea.
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Munc13-1 is required for presynaptic long-term potentiation.
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Murine forkhead/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract.
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Murine regulatory T cells contain hyperproliferative and death-prone subsets with differential ICOS expression.
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Murine versus human apolipoprotein E4: differential facilitation of and co-localization in cerebral amyloid angiopathy and amyloid plaques in APP transgenic mouse models.
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Muscle atrophy in transgenic mice expressing a human TSC1 transgene.
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Muscle expression of mutant androgen receptor accounts for systemic and motor neuron disease phenotypes in spinal and bulbar muscular atrophy.
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Muscle oxidative capacity during IL-6-dependent cancer cachexia.
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Mutant IDH1 Disrupts the Mouse Subventricular Zone and Alters Brain Tumor Progression.
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Mutual regulation of Src family kinases and the neurotrophin receptor TrkB.
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Myeloablative temozolomide enhances CD8⁺ T-cell responses to vaccine and is required for efficacy against brain tumors in mice.
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Myocardial G protein-coupled receptor kinases: implications for heart failure therapy.
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Myocardial beta-adrenergic receptor signaling in vivo: insights from transgenic mice.
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Myocardial expression of a constitutively active alpha 1B-adrenergic receptor in transgenic mice induces cardiac hypertrophy.
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Myocardial overexpression of GRK3 in transgenic mice: evidence for in vivo selectivity of GRKs.
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Myocardial overexpression of adrenergic receptors and receptor kinases.
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Myocyte specific overexpression of myoglobin impairs angiogenesis after hind-limb ischemia.
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Myocyte-enriched calcineurin-interacting protein, MCIP1, inhibits cardiac hypertrophy in vivo.
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Myosin light chain-2 luciferase transgenic mice reveal distinct regulatory programs for cardiac and skeletal muscle-specific expression of a single contractile protein gene.
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Myotilin overexpression enhances myopathology in the LGMD1A mouse model.
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N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma.
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N-myc can substitute for insulin-like growth factor signaling in a mouse model of sonic hedgehog-induced medulloblastoma.
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NADPH Oxidase-Derived Peroxynitrite Drives Inflammation in Mice and Human Nonalcoholic Steatohepatitis via TLR4-Lipid Raft Recruitment.
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NF1 deletion generates multiple subtypes of soft-tissue sarcoma that respond to MEK inhibition.
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NHERF1/EBP50 is an organizer of polarity structures and a diagnostic marker in ependymoma.
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NOTCH signaling in skeletal progenitors is critical for fracture repair.
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NPM-ALK transgenic mice spontaneously develop T-cell lymphomas and plasma cell tumors.
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Natural IgM is produced by CD5- plasma cells that occupy a distinct survival niche in bone marrow.
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Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways.
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Neocortical disynaptic inhibition requires somatodendritic integration in interneurons.
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Neonates support lymphopenia-induced proliferation.
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Neural cell adhesion molecule-secreting transgenic mice display abnormalities in GABAergic interneurons and alterations in behavior.
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Neurod6 expression defines new retinal amacrine cell subtypes and regulates their fate.
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Neurofibromatosis Type 1 and tumorigenesis: molecular mechanisms and therapeutic implications.
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Neuron-specific Sumo1-3 knockdown in mice impairs episodic and fear memories.
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Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis.
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Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis.
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Neurotrophic factor-α1 prevents stress-induced depression through enhancement of neurogenesis and is activated by rosiglitazone.
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Neurotrophin-3 signaling maintains maturational homeostasis between neuronal populations in the olfactory epithelium.
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New modules are added to vibrissal premotor circuitry with the emergence of exploratory whisking.
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Niche-mediated BMP/SMAD signaling regulates lung alveolar stem cell proliferation and differentiation.
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Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms.
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Nitric oxide-mediated intracellular growth restriction of pathogenic Rhodococcus equi can be prevented by iron.
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Nitric oxide-mediated regulation of β-amyloid clearance via alterations of MMP-9/TIMP-1.
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Nogo receptor 1 is expressed by nearly all retinal ganglion cells.
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Non-alcoholic steatohepatitis pathogenesis: role of repair in regulating the disease progression.
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Non-erythroid effects of erythropoietin.
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Noncoding transcription controls downstream promoters to regulate T-cell receptor alpha recombination.
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Nordihydroguaiaretic acid (NDGA) inhibits the IGF-1 and c-erbB2/HER2/neu receptors and suppresses growth in breast cancer cells.
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Normal cardiac function in mice with supraphysiological cardiac creatine levels.
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Notch signaling in postnatal joint chondrocytes, but not subchondral osteoblasts, is required for articular cartilage and joint maintenance.
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Notch signaling maintains Leydig progenitor cells in the mouse testis.
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Notch signalling regulates asymmetric division and inter-conversion between lgr5 and bmi1 expressing intestinal stem cells.
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Notch-1 regulates pulmonary neuroendocrine cell differentiation in cell lines and in transgenic mice.
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Notch/Delta expression in the developing mouse lung.
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Novel role of 4-hydroxy-2-nonenal in AIFm2-mediated mitochondrial stress signaling.
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Novel sphingosine-1-phosphate receptor modulator KRP203 combined with locally delivered regulatory T cells induces permanent acceptance of pancreatic islet allografts.
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Nrf2 inactivation enhances placental angiogenesis in a preeclampsia mouse model and improves maternal and fetal outcomes.
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Nrf2 promotes alveolar mitochondrial biogenesis and resolution of lung injury in Staphylococcus aureus pneumonia in mice.
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Null mutation of c-fos impairs structural and functional plasticities in the kindling model of epilepsy.
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Number of pregnancies and ovariectomy modify mammary carcinoma development in transgenic HER-2/neu female mice.
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OCD-Like behaviors caused by a neuropotentiating transgene targeted to cortical and limbic D1+ neurons.
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Obesity-Induced Colorectal Cancer Is Driven by Caloric Silencing of the Guanylin-GUCY2C Paracrine Signaling Axis.
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Oligodendroglial and pan-neural crest expression of Cre recombinase directed by Sox10 enhancer.
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Oncogenic role of the frizzled-7/beta-catenin pathway in hepatocellular carcinoma.
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Operant self-stimulation of dopamine neurons in the substantia nigra.
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Opposing actions of Stat1 and Stat6 on IL-13-induced up-regulation of early growth response-1 and platelet-derived growth factor ligands in pulmonary fibroblasts.
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Organization and analysis of the complete rat calmodulin-dependent protein kinase IV gene.
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Organizing pneumonia in mice and men.
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Osteopontin has a protective role in prostate tumor development in mice.
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Over-expression of cyclin D1 regulates Cdk4 protein synthesis.
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Overexpression of TNNI3K, a cardiac-specific MAPKKK, promotes cardiac dysfunction.
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Overexpression of androgen-binding protein/sex hormone-binding globulin in male transgenic mice: tissue distribution and phenotypic disorders.
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Overexpression of angiotensin AT1 receptor transgene in the mouse myocardium produces a lethal phenotype associated with myocyte hyperplasia and heart block.
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Overexpression of extracellular superoxide dismutase decreases lung injury after exposure to oil fly ash.
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Overexpression of extracellular superoxide dismutase protects mice from radiation-induced lung injury.
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Overexpression of extracellular superoxide dismutase reduces acute radiation induced lung toxicity.
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Overexpression of mitogen-activated protein kinase kinase 6 in the heart improves functional recovery from ischemia in vitro and protects against myocardial infarction in vivo.
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Overexpression of pre-pro-cholecystokinin stimulates beta-cell proliferation in mouse and human islets with retention of islet function.
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Overexpression of the rat sarcoplasmic reticulum Ca2+ ATPase gene in the heart of transgenic mice accelerates calcium transients and cardiac relaxation.
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Overview of mouse models of autism spectrum disorders.
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Oxidative phenotype protects myofibers from pathological insults induced by chronic heart failure in mice.
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Ozone inhalation promotes CX3CR1-dependent maturation of resident lung macrophages that limit oxidative stress and inflammation.
-
PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis.
-
PGC-1α provides a transcriptional framework for synchronous neurotransmitter release from parvalbumin-positive interneurons.
-
PP6 controls T cell development and homeostasis by negatively regulating distal TCR signaling.
-
PPAR-δ is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically.
-
PPARβ/δ selectively regulates phenotypic features of age-related macular degeneration.
-
Pain sensitivity and vasopressin analgesia are mediated by a gene-sex-environment interaction.
-
Pancreatic expression and secretion of human islet amyloid polypeptide in a transgenic mouse.
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Paracrine Wnt5a-β-Catenin Signaling Triggers a Metabolic Program that Drives Dendritic Cell Tolerization.
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Paracrine modulation of cholangiocyte serotonin synthesis orchestrates biliary remodeling in adults.
-
Pathophysiology of vascular smooth muscle in renin promoter-T-antigen transgenic mice.
-
Patterns of HIV-1 mRNA expression in transgenic mice are tissue-dependent.
-
Pax7 expressing cells contribute to dermal wound repair, regulating scar size through a β-catenin mediated process.
-
Peracetylated N-acetylmannosamine, a synthetic sugar molecule, efficiently rescues muscle phenotype and biochemical defects in mouse model of sialic acid-deficient myopathy.
-
Peripheral androgen receptor gene suppression rescues disease in mouse models of spinal and bulbar muscular atrophy.
-
Peripheral mobilization of recipient bone marrow-derived endothelial progenitor cells enhances pancreatic islet revascularization and engraftment after intraportal transplantation.
-
Peritubular myoid cells are not the migrating population required for testis cord formation in the XY gonad.
-
Perivascular mural cells of the mouse choroid demonstrate morphological diversity that is correlated to vasoregulatory function.
-
Persistent nuclear factor-kappa B activation in Ucp2-/- mice leads to enhanced nitric oxide and inflammatory cytokine production.
-
Pharmacogenomic effects of apolipoprotein e on intracerebral hemorrhage.
-
Pharmacologically targeting beta-catenin for NF1 associated deficiencies in fracture repair.
-
Phenotypic Characterization of MIP-CreERT1Lphi Mice With Transgene-Driven Islet Expression of Human Growth Hormone.
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Phenotypic consequences of lung-specific inducible expression of FGF-3.
-
Phosducin regulates transmission at the photoreceptor-to-ON-bipolar cell synapse.
-
Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging.
-
Phosphatase and tensin homologue on chromosome 10 (PTEN) directs prostaglandin E2-mediated fibroblast responses via regulation of E prostanoid 2 receptor expression.
-
Phosphorylation of MeCP2 at Ser421 contributes to chronic antidepressant action.
-
Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the beta 2-adrenoceptor.
-
Physiological induction of a beta-adrenergic receptor kinase inhibitor transgene preserves ss-adrenergic responsiveness in pressure-overload cardiac hypertrophy.
-
Pik3c3 deletion in pyramidal neurons results in loss of synapses, extensive gliosis and progressive neurodegeneration.
-
Pitchfork regulates primary cilia disassembly and left-right asymmetry.
-
Plasticity and behavior: new genetic techniques to address multiple forms and functions.
-
Plasticity of Hopx(+) type I alveolar cells to regenerate type II cells in the lung.
-
Plexin-D1 is a novel regulator of germinal centers and humoral immune responses.
-
Podocan, a novel small leucine-rich repeat protein expressed in the sclerotic glomerular lesion of experimental HIV-associated nephropathy.
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Polycystic kidney disease in SBM transgenic mice: role of c-myc in disease induction and progression.
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Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA.
-
Postnatal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche.
-
Potentiation of beta-adrenergic signaling by gene transfer.
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Precise pattern of recombination in serotonergic and hypothalamic neurons in a Pdx1-cre transgenic mouse line.
-
Prefrontal cortical mechanisms underlying delayed alternation in mice.
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Presynaptic Inputs to Any CNS Projection Neuron Identified by Dual Recombinant Virus Infection.
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Production and characterization of astrocyte-derived human apolipoprotein E isoforms from immortalized astrocytes and their interactions with amyloid-beta.
-
Progress towards gene therapy for Duchenne muscular dystrophy.
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Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2.
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Progressive glomerulosclerosis and enhanced renal accumulation of basement membrane components in mice transgenic for human immunodeficiency virus type 1 genes.
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Progressive loss of synaptic integrity in human apolipoprotein E4 targeted replacement mice and attenuation by apolipoprotein E2.
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Prolonged Mitosis of Neural Progenitors Alters Cell Fate in the Developing Brain.
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Pronounced thrombocytosis in transgenic mice expressing reduced levels of Mpl in platelets and terminally differentiated megakaryocytes.
-
Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model.
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Prostate-specific expression of p53(R172L) differentially regulates p21, Bax, and mdm2 to inhibit prostate cancer progression and prolong survival.
-
Proteasome overload is a common stress factor in multiple forms of inherited retinal degeneration.
-
Protection against autoimmunity in nonlymphopenic hosts by CD4+ CD25+ regulatory T cells is antigen-specific and requires IL-10 and TGF-beta.
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Protection against chronic pancreatitis and pancreatic fibrosis in mice overexpressing pancreatic secretory trypsin inhibitor.
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Protective immunosurveillance and therapeutic antitumor activity of gammadelta T cells demonstrated in a mouse model of prostate cancer.
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Proteolytic cleavage and PKA phosphorylation of α1C subunit are not required for adrenergic regulation of CaV1.2 in the heart.
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Pseudopod-like basal cell processes in intestinal cholecystokinin cells.
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Purification and characterization of astrocyte-secreted apolipoprotein E and J-containing lipoproteins from wild-type and human apoE transgenic mice.
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Quantitative genetic variation in CD19 expression correlates with autoimmunity.
-
Quantitative measurement of postural sway in mouse models of human neurodegenerative disease.
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RBP-Jκ-dependent Notch signaling is required for murine articular cartilage and joint maintenance.
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RGS expression rate-limits recovery of rod photoresponses.
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RIP3 induces apoptosis independent of pronecrotic kinase activity.
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RXR is an essential component of the oncogenic PML/RARA complex in vivo.
-
Rac1 GTPase-deficient mouse lens exhibits defects in shape, suture formation, fiber cell migration and survival.
-
Rapamycin delays disease onset and prevents PrP plaque deposition in a mouse model of Gerstmann-Sträussler-Scheinker disease.
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Rare SOX2+ Airway Progenitor Cells Generate KRT5+ Cells that Repopulate Damaged Alveolar Parenchyma following Influenza Virus Infection.
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Rare codons capacitate Kras-driven de novo tumorigenesis.
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Rbm8a haploinsufficiency disrupts embryonic cortical development resulting in microcephaly.
-
Re-examination of CD91 function in GRP94 (glycoprotein 96) surface binding, uptake, and peptide cross-presentation.
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Re-patterning of skeletal muscle energy metabolism by fat storage-inducing transmembrane protein 2.
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Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice.
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Recombinant adeno-associated virus for muscle directed gene therapy.
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Recoverin improves rod-mediated vision by enhancing signal transmission in the mouse retina.
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Recruitment of Donor T Cells to the Eyes During Ocular GVHD in Recipients of MHC-Matched Allogeneic Hematopoietic Stem Cell Transplants.
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Reduced D2-mediated signaling activity and trans-synaptic upregulation of D1 and D2 dopamine receptors in mice overexpressing the dopamine transporter.
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Reduced levels of human apoE4 protein in an animal model of cognitive impairment.
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Reducing cerebral microvascular amyloid-beta protein deposition diminishes regional neuroinflammation in vasculotropic mutant amyloid precursor protein transgenic mice.
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Reduction of cardiomyocyte S-nitrosylation by S-nitrosoglutathione reductase protects against sepsis-induced myocardial depression.
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Regeneration of Thyroid Function by Transplantation of Differentiated Pluripotent Stem Cells.
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Regional CBF in apolipoprotein E-deficient and wild type mice during focal cerebral ischemia.
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Regression of drug-resistant lung cancer by the combination of rosiglitazone and carboplatin.
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Regulation and properties of the rat Ca2+/calmodulin-dependent protein kinase IV gene and its protein products.
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Regulation of B lymphocyte development and activation by the CD19/CD21/CD81/Leu 13 complex requires the cytoplasmic domain of CD19.
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Regulation of T cell receptor delta gene rearrangement by CBF/PEBP2.
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Regulation of T cell receptor delta gene rearrangement by c-Myb.
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Regulation of TCRβ allelic exclusion by gene segment proximity and accessibility.
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Regulation of age-related macular degeneration-like pathology by complement factor H.
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Regulation of basement membrane-reactive B cells in BXSB, (NZBxNZW)F1, NZB, and MRL/lpr lupus mice.
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Regulation of gene expression in the lung.
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Regulation of humoral immune responses by CD21/CD35.
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Regulation of mast cell survival and function by tuberous sclerosis complex 1.
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Regulation of mitochondrial biogenesis in skeletal muscle by CaMK.
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Regulation of myocardial betaARK1 expression in catecholamine-induced cardiac hypertrophy in transgenic mice overexpressing alpha1B-adrenergic receptors.
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Regulation of the TCRalpha repertoire by the survival window of CD4(+)CD8(+) thymocytes.
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Regulation of the brain's vascular responses to oxygen.
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Regulator of G-protein signaling-21 (RGS21) is an inhibitor of bitter gustatory signaling found in lingual and airway epithelia.
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Regulatory B cell (B10 Cell) expansion during Listeria infection governs innate and cellular immune responses in mice.
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Regulatory elements governing transcription in specialized myofiber subtypes.
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Relaxed negative selection in germinal centers and impaired affinity maturation in bcl-xL transgenic mice.
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Remembrance of things past.
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Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors.
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Remote sites of structural atrophy predict later amyloid formation in a mouse model of Alzheimer's disease.
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Removable cranial windows for long-term imaging in awake mice.
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Repair-related activation of hedgehog signaling in stromal cells promotes intrahepatic hypothyroidism.
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Reparative capacity of airway epithelium impacts deposition and remodeling of extracellular matrix.
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Repression of B7.2 on self-reactive B cells is essential to prevent proliferation and allow Fas-mediated deletion by CD4(+) T cells.
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Reprogramming after chromosome transfer into mouse blastomeres.
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Requirement for Ca2+/calmodulin-dependent kinase type IV/Gr in setting the thymocyte selection threshold.
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Requirement for reactive oxygen species in serum-induced and platelet-derived growth factor-induced growth of airway smooth muscle.
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Rescue of HIV-1 broad neutralizing antibody-expressing B cells in 2F5 VH x VL knockin mice reveals multiple tolerance controls.
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Resistance to thyroid hormone is modulated in vivo by the nuclear receptor corepressor (NCOR1).
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Resolving postoperative neuroinflammation and cognitive decline.
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Response to cardiac sympathetic activation in transgenic mice overexpressing beta 2-adrenergic receptor.
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Restoration of beta-adrenergic receptor signaling and contractile function in heart failure by disruption of the betaARK1/phosphoinositide 3-kinase complex.
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Restoring neuronal progranulin reverses deficits in a mouse model of frontotemporal dementia.
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Retina- and ventral forebrain-specific Cre recombinase activity in transgenic mice.
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Retinal ganglion cells with distinct directional preferences differ in molecular identity, structure, and central projections.
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Retrograde BMP signaling regulates trigeminal sensory neuron identities and the formation of precise face maps.
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Rho GDP dissociation inhibitor-mediated disruption of Rho GTPase activity impairs lens fiber cell migration, elongation and survival.
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Rho GTPase inactivation impairs lens growth and integrity.
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RhoA Kinase Inhibition With Fasudil Versus Simvastatin in Murine Models of Cerebral Cavernous Malformations.
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Role for ETS domain transcription factors Pea3/Erm in mouse lung development.
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Role for Nox1 NADPH oxidase in atherosclerosis.
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Role for hedgehog signaling in hepatic stellate cell activation and viability.
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Role for the target enzyme in deactivation of photoreceptor G protein in vivo.
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Role of C-terminal serines in desensitization and phosphorylation of the mouse thromboxane receptor.
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Role of LAT in the granule-mediated cytotoxicity of CD8 T cells.
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Role of interleukin 12 and costimulators in T cell anergy in vivo.
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Role of nitric oxide in murine conventional outflow physiology.
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Role of platelet surface PF4 antigenic complexes in heparin-induced thrombocytopenia pathogenesis: diagnostic and therapeutic implications.
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Role of prostacyclin in the cardiovascular response to thromboxane A2.
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Role of sodium channel deglycosylation in the genesis of cardiac arrhythmias in heart failure.
-
Role of ubiquitin-like protein FAT10 in epithelial apoptosis in renal disease.
-
Ryk controls remapping of motor cortex during functional recovery after spinal cord injury.
-
S-Nitrosoglutathione Reductase Dysfunction Contributes to Obesity-Associated Hepatic Insulin Resistance via Regulating Autophagy.
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S-Nitrosylation of Calcium-Handling Proteins in Cardiac Adrenergic Signaling and Hypertrophy.
-
S100A15, an antimicrobial protein of the skin: regulation by E. coli through Toll-like receptor 4.
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SCN5A variant that blocks fibroblast growth factor homologous factor regulation causes human arrhythmia.
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STAT1 signaling in CD8 T cells is required for their clonal expansion and memory formation following viral infection in vivo.
-
SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice.
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Sapap3 deletion causes mGluR5-dependent silencing of AMPAR synapses.
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Scavenging nucleic acid debris to combat autoimmunity and infectious disease.
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Sec63 and Xbp1 regulate IRE1α activity and polycystic disease severity.
-
Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy.
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Selection of TCR V alpha by MHC class II predicts superantigen reactivity.
-
Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.
-
Sequence elements required for transcriptional activity of the human myoglobin promoter in intact myocardium.
-
Serum antibodies to huntingtin interacting protein-1: a new blood test for prostate cancer.
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Serum cholesterol levels and tumor growth in a PTEN-null transgenic mouse model of prostate cancer.
-
Setting clock speed in mammals: the CK1 epsilon tau mutation in mice accelerates circadian pacemakers by selectively destabilizing PERIOD proteins.
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Severe lung fibrosis requires an invasive fibroblast phenotype regulated by hyaluronan and CD44.
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Sex differences in response to chronic mild stress and congenital serotonin deficiency.
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Sex-Dependent Glial Signaling in Pathological Pain: Distinct Roles of Spinal Microglia and Astrocytes.
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Singular value decomposition-based regression identifies activation of endogenous signaling pathways in vivo.
-
Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization.
-
Skin abnormalities in mice transgenic for plasminogen activator inhibitor 1: implications for the regulation of desquamation and follicular neogenesis by plasminogen activator enzymes.
-
Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver.
-
Smad3 has a critical role in TGF-beta-mediated growth inhibition and apoptosis in colonic epithelial cells.
-
Small ubiquitin-like modifier 3-modified proteome regulated by brain ischemia in novel small ubiquitin-like modifier transgenic mice: putative protective proteins/pathways.
-
Smoothened is a master regulator of adult liver repair.
-
Sodium butyrate ameliorates histone hypoacetylation and neurodegenerative phenotypes in a mouse model for DRPLA.
-
Sonic hedgehog from pharyngeal arch 1 epithelium is necessary for early mandibular arch cell survival and later cartilage condensation differentiation.
-
Sox2 expression in Schwann cells inhibits myelination in vivo and induces influx of macrophages to the nerve.
-
Sox2 is required for development of taste bud sensory cells.
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Sox2 regulates cholinergic amacrine cell positioning and dendritic stratification in the retina.
-
Spinal CCL2 Promotes Central Sensitization, Long-Term Potentiation, and Inflammatory Pain via CCR2: Further Insights into Molecular, Synaptic, and Cellular Mechanisms.
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Spinal axon regeneration evoked by replacing two growth cone proteins in adult neurons.
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Split tolerance in peripheral B cell subsets in mice expressing a low level of Igkappa-reactive ligand.
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Sry and the testis: molecular pathways of organogenesis.
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Stability of Th1 and Th2 populations.
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Stabilization of beta-catenin in XY gonads causes male-to-female sex-reversal.
-
Staphylococcus aureus sepsis induces early renal mitochondrial DNA repair and mitochondrial biogenesis in mice.
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Statistical analysis of skin tumor data from Tg.AC mouse bioassays.
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Stimulation of slow skeletal muscle fiber gene expression by calcineurin in vivo.
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Stoichiometry of Gata4, Mef2c, and Tbx5 influences the efficiency and quality of induced cardiac myocyte reprogramming.
-
Stoichiometry of the T cell antigen receptor (TCR) complex: each TCR/CD3 complex contains one TCR alpha, one TCR beta, and two CD3 epsilon chains.
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Strategies for analysis of gene expression: pulmonary surfactant proteins.
-
Stressors and antistressors: how do they influence life span in HER-2/neu transgenic mice?
-
Stromal cell independent B cell development in vitro: generation and recovery of autoreactive clones.
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Suppression of FIP200 and autophagy by tumor-derived lactate promotes naïve T cell apoptosis and affects tumor immunity.
-
Suppression of food intake by glucagon-like peptide-1 receptor agonists: relative potencies and role of dipeptidyl peptidase-4.
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Suppression of revertant fibers in mdx mice by expression of a functional dystrophin.
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Suppressor and activator functions mediated by a repeated heptad sequence in the liver fatty acid-binding protein gene (Fabpl). Effects on renal, small intestinal, and colonic epithelial cell gene expression in transgenic mice.
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Sustained activation of Rac1 in hepatic stellate cells promotes liver injury and fibrosis in mice.
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Synergistic Interactions between Abeta, tau, and alpha-synuclein: acceleration of neuropathology and cognitive decline.
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Systemic administration of HVJ viral coat-liposome complex containing human insulin vector decreases glucose level in diabetic mouse: A model of gene therapy.
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Systemic transforming growth factor-beta1 gene therapy induces Foxp3+ regulatory cells, restores self-tolerance, and facilitates regeneration of beta cell function in overtly diabetic nonobese diabetic mice.
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T cell receptor (TCR) and transforming growth factor β (TGF-β) signaling converge on DNA (cytosine-5)-methyltransferase to control forkhead box protein 3 (foxp3) locus methylation and inducible regulatory T cell differentiation.
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T cell-mediated elimination of B7.2 transgenic B cells.
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T-bet-dependent expression of osteopontin contributes to T cell polarization.
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T-cell receptor α enhancer is inactivated in αβ T lymphocytes.
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TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages.
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TCF1 Is Required for the T Follicular Helper Cell Response to Viral Infection.
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TEX11 is mutated in infertile men with azoospermia and regulates genome-wide recombination rates in mouse.
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TGF-beta-induced myelin peptide-specific regulatory T cells mediate antigen-specific suppression of induction of experimental autoimmune encephalomyelitis.
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TMEM231, mutated in orofaciodigital and Meckel syndromes, organizes the ciliary transition zone.
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TNF-α/TNFR1 Signaling is Required for the Full Expression of Acute and Chronic Itch in Mice via Peripheral and Central Mechanisms.
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TNFR2 interposes the proliferative and NF-κB-mediated inflammatory response by podocytes to TNF-α.
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TR-FRET-based duplex immunoassay reveals an inverse correlation of soluble and aggregated mutant huntingtin in huntington's disease.
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TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism.
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TRPC3 channels confer cellular memory of recent neuromuscular activity.
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TRPV4 is necessary for trigeminal irritant pain and functions as a cellular formalin receptor.
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Tamoxifen-inducible gene deletion reveals a distinct cell type associated with trabecular bone, and direct regulation of PTHrP expression and chondrocyte morphology by Ihh in growth region cartilage.
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Targeted ANP32E mutant mice do not demonstrate obvious movement defects.
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Targeted developmental overexpression of calmodulin induces proliferative and hypertrophic growth of cardiomyocytes in transgenic mice.
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Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice.
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Targeted expression of calmodulin increases ventricular cardiomyocyte proliferation and deoxyribonucleic acid synthesis during mouse development.
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Targeted inactivation of synaptic HRG4 (UNC119) causes dysfunction in the distal photoreceptor and slow retinal degeneration, revealing a new function.
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Targeted inhibition of beta-adrenergic receptor kinase-1-associated phosphoinositide-3 kinase activity preserves beta-adrenergic receptor signaling and prolongs survival in heart failure induced by calsequestrin overexpression.
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Targeted inhibition of calcineurin in pressure-overload cardiac hypertrophy. Preservation of systolic function.
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Targeted overexpression of G protein-coupled receptor kinase-2 in osteoblasts promotes bone loss.
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Targeted overexpression of an inactive calmodulin that binds Ca2+ to the mouse pancreatic beta-cell results in impaired secretion and chronic hyperglycemia.
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Targeted overexpression of phospholamban to mouse atrium depresses Ca2+ transport and contractility.
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Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis.
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Targeted therapy for glioblastoma multiforme neoplastic meningitis with intrathecal delivery of an oncolytic recombinant poliovirus.
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Targeting CD4 coreceptor expression to postselection thymocytes reveals that CD4/CD8 lineage choice is neither error-prone nor stochastic.
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Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature.
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Targeting eNOS in pancreatic cancer.
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Targeting phosphorylation of eukaryotic initiation factor-2α to treat human disease.
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Targeting stem cell behavior in desmoid tumors (aggressive fibromatosis) by inhibiting hedgehog signaling.
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Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy.
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Tau Protein Mediates APP Intracellular Domain (AICD)-Induced Alzheimer's-Like Pathological Features in Mice.
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Tau is essential to beta -amyloid-induced neurotoxicity.
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Tau-knockout mice show reduced GSK3-induced hippocampal degeneration and learning deficits.
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Tcra gene recombination is supported by a Tcra enhancer- and CTCF-dependent chromatin hub.
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Temporal and lineage-specific control of T cell receptor alpha/delta gene rearrangement by T cell receptor alpha and delta enhancers.
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Temporal control of gene deletion in sensory ganglia using a tamoxifen-inducible Advillin-Cre-ERT2 recombinase mouse.
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Temporal differences in granulosa cell specification in the ovary reflect distinct follicle fates in mice.
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Temporomandibular joint pain: a critical role for Trpv4 in the trigeminal ganglion.
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Testosterone levels influence mouse fetal Leydig cell progenitors through notch signaling.
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Th17 cells are long lived and retain a stem cell-like molecular signature.
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The APOE4 genotype alters the response of microglia and macrophages to 17beta-estradiol.
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The Ability of Nitric Oxide to Lower Intraocular Pressure Is Dependent on Guanylyl Cyclase.
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The CD19 signal transduction molecule is a response regulator of B-lymphocyte differentiation.
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The DEP domain determines subcellular targeting of the GTPase activating protein RGS9 in vivo.
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The ErbB2ΔEx16 splice variant is a major oncogenic driver in breast cancer that promotes a pro-metastatic tumor microenvironment.
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The PDZ motif of the α1C subunit is not required for surface trafficking and adrenergic modulation of CaV1.2 channel in the heart.
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The acute promyelocytic leukemia PML-RAR alpha protein induces hepatic preneoplastic and neoplastic lesions in transgenic mice.
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The ankyrin-B C-terminal domain determines activity of ankyrin-B/G chimeras in rescue of abnormal inositol 1,4,5-trisphosphate and ryanodine receptor distribution in ankyrin-B (-/-) neonatal cardiomyocytes.
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The antiapoptotic protein Bcl-xL is dispensable for the development of effector and memory T lymphocytes.
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The apolipoprotein-E-mimetic COG112 protects amyloid precursor protein intracellular domain-overexpressing animals from Alzheimer's disease-like pathological features.
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The arterial wall and the atherosclerotic lesion.
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The auxiliary subunit KChIP2 is an essential regulator of homeostatic excitability.
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The c-FLIPL cleavage product p43FLIP promotes activation of extracellular signal-regulated kinase (ERK), nuclear factor κB (NF-κB), and caspase-8 and T cell survival.
-
The candidate sour taste receptor, PKD2L1, is expressed by type III taste cells in the mouse.
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The cell of origin and subtype of K-Ras-induced lung tumors are modified by Notch and Sox2.
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The cellular and synaptic location of activated TrkB in mouse hippocampus during limbic epileptogenesis.
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The channel kinase, TRPM7, is required for early embryonic development.
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The chloride transporter Na(+)-K(+)-Cl- cotransporter isoform-1 contributes to intracellular chloride increases after in vitro ischemia.
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The class III kinase Vps34 promotes T lymphocyte survival through regulating IL-7Rα surface expression.
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The clinical application of monoclonal antibody therapies in renal transplantation.
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The cyclic AMP response element directs tyrosine hydroxylase expression in catecholaminergic central and peripheral nervous system cell lines from transgenic mice.
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The development and function of memory regulatory T cells after acute viral infections.
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The dopamine transporter: a crucial component regulating dopamine transmission.
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The double-stranded RNA-activated protein kinase mediates viral-induced encephalitis.
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The effect of melatonin treatment regimen on mammary adenocarcinoma development in HER-2/neu transgenic mice.
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The effects of NOS2 gene deletion on mice expressing mutated human AbetaPP.
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The effects of brain serotonin deficiency on behavioural disinhibition and anxiety-like behaviour following mild early life stress.
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The effects of congenital brain serotonin deficiency on responses to chronic fluoxetine.
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The essential role of LAT in thymocyte development during transition from the double-positive to single-positive stage.
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The extracellular matrix protein mindin regulates trafficking of murine eosinophils into the airspace.
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The fate of effector CD8 T cells in vivo is controlled by the duration of antigen stimulation.
-
The fornix provides multiple biomarkers to characterize circuit disruption in a mouse model of Alzheimer's disease.
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The generation and characterization of novel Col1a1FRT-Cre-ER-T2-FRT and Col1a1FRT-STOP-FRT-Cre-ER-T2 mice for sequential mutagenesis.
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The homophilic adhesion molecule sidekick-1 contributes to augmented podocyte aggregation in HIV-associated nephropathy.
-
The human D1A dopamine receptor gene promoter directs expression of a reporter gene to the central nervous system in transgenic mice.
-
The human plasminogen activator inhibitor type I gene promoter targets to kidney.
-
The human poliovirus receptor. Receptor-virus interaction and parameters of disease specificity.
-
The impact of bcl-2 expression and bax deficiency on prostate homeostasis in vivo.
-
The importance of Src homology 2 domain-containing leukocyte phosphoprotein of 76 kilodaltons sterile-alpha motif domain in thymic selection and T-cell activation.
-
The importance of the Erk pathway in the development of linker for activation of T cells-mediated autoimmunity.
-
The in vivo balance between B cell clonal expansion and elimination is regulated by CD95 both on B cells and in their micro-environment.
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The interaction of escitalopram and R-citalopram at the human serotonin transporter investigated in the mouse.
-
The intestinal tuft cell nanostructure in 3D.
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The kidney and hypertension: lessons from mouse models.
-
The matrix protein Fibulin-5 is at the interface of tissue stiffness and inflammation in fibrosis.
-
The oncogenic properties of EWS/WT1 of desmoplastic small round cell tumors are unmasked by loss of p53 in murine embryonic fibroblasts.
-
The organization of submodality-specific touch afferent inputs in the vibrissa column.
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The requirement of linker for activation of T cells in the primary and memory responses of CD8 T cells.
-
The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium.
-
The role of hepatocyte hemojuvelin in the regulation of bone morphogenic protein-6 and hepcidin expression in vivo.
-
The role of tuberous sclerosis complex 1 in regulating innate immunity.
-
The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse.
-
The tau N279K exon 10 splicing mutation recapitulates frontotemporal dementia and parkinsonism linked to chromosome 17 tauopathy in a mouse model.
-
The therapeutic and preventive effect of RRR-alpha-vitamin E succinate on prostate cancer via induction of insulin-like growth factor binding protein-3.
-
The transcription factor calcium-response factor limits NMDA receptor-dependent transcription in the developing brain.
-
The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression.
-
The use of enzyme therapy to regulate the metabolic and phenotypic consequences of adenosine deaminase deficiency in mice. Differential impact on pulmonary and immunologic abnormalities.
-
Therapeutic B cell depletion impairs adaptive and autoreactive CD4+ T cell activation in mice.
-
Thrombospondin-4 contributes to spinal sensitization and neuropathic pain states.
-
Thymic expression of the transcription factor Nur77 rescues the T cell but not the B cell abnormality of gld/gld mice.
-
Thymosin beta-4 regulates activation of hepatic stellate cells via hedgehog signaling.
-
Tie2(+) bone marrow endothelial cells regulate hematopoietic stem cell regeneration following radiation injury.
-
Tissue-specific expression of the human CD19 gene in transgenic mice inhibits antigen-independent B-lymphocyte development.
-
Tissue-specific expression of the rat androgen-binding protein/sex hormone-binding globulin gene in transgenic mice.
-
Tmprss6 is a genetic modifier of the Hfe-hemochromatosis phenotype in mice.
-
Tnni3k modifies disease progression in murine models of cardiomyopathy.
-
Toll-like receptor 7 mediates pruritus.
-
Topical and oral administration of the natural water-soluble antioxidant from spinach reduces the multiplicity of papillomas in the Tg.AC mouse model.
-
Transactivation of the epidermal growth factor receptor mediates parathyroid hormone and prostaglandin F2 alpha-stimulated mitogen-activated protein kinase activation in cultured transgenic murine osteoblasts.
-
Transcription factors MYOCD, SRF, Mesp1 and SMARCD3 enhance the cardio-inducing effect of GATA4, TBX5, and MEF2C during direct cellular reprogramming.
-
Transcription-dependent mobilization of nucleosomes at accessible TCR gene segments in vivo.
-
Transcriptional regulator Id2 is required for the CD4 T cell immune response in the development of experimental autoimmune encephalomyelitis.
-
Transfer of CD8+ T cell memory using Bcl-2 as a marker.
-
Transgenic animals in integrative biology: approaches and interpretations of outcome.
-
Transgenic expression of green fluorescence protein can cause dilated cardiomyopathy.
-
Transgenic expression of pancreatic secretory trypsin inhibitor-1 rescues SPINK3-deficient mice and restores a normal pancreatic phenotype.
-
Transgenic expression of pancreatic secretory trypsin inhibitor-I ameliorates secretagogue-induced pancreatitis in mice.
-
Transgenic expression of the viral FLIP MC159 causes lpr/gld-like lymphoproliferation and autoimmunity.
-
Transgenic manipulation of beta-adrenergic receptor kinase modifies cardiac myocyte contraction to norepinephrine.
-
Transgenic mice as a model to study the role of TGF-beta-related molecules in hair follicles.
-
Transgenic mice as a tool to study the renin-angiotensin system.
-
Transgenic mice expressing a constitutively active retinoic acid receptor in the lens exhibit ocular defects.
-
Transgenic mice expressing the myotilin T57I mutation unite the pathology associated with LGMD1A and MFM.
-
Transgenic mice overproducing islet amyloid polypeptide have increased insulin storage and secretion in vitro.
-
Transgenic mice with cardiac overexpression of alpha1B-adrenergic receptors. In vivo alpha1-adrenergic receptor-mediated regulation of beta-adrenergic signaling.
-
Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells.
-
Transgenic overexpression of the Ca2+-binding protein S100A1 in the heart leads to increased in vivo myocardial contractile performance.
-
Transgenic overproduction of islet amyloid polypeptide (amylin) is not sufficient for islet amyloid formation.
-
Transgenic restoration of long-chain n-3 fatty acids in insulin target tissues improves resolution capacity and alleviates obesity-linked inflammation and insulin resistance in high-fat-fed mice.
-
Transgenic ω-3 PUFA enrichment alters morphology and gene expression profile in adipose tissue of obese mice: Potential role for protectins.
-
Transglutaminase 2 protects against ischemic stroke.
-
Transient activation of beta -catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice.
-
Transthoracic echocardiography in models of cardiac disease in the mouse.
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Traumatic brain injury exacerbates neurodegenerative pathology: improvement with an apolipoprotein E-based therapeutic.
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Treatment of Inherited Eye Defects by Systemic Hematopoietic Stem Cell Transplantation.
-
TrkB activation by 7, 8-dihydroxyflavone increases synapse AMPA subunits and ameliorates spatial memory deficits in a mouse model of Alzheimer's disease.
-
TrkB signaling is required for behavioral sensitization and conditioned place preference induced by a single injection of cocaine.
-
Tumor Endothelial Cells with Distinct Patterns of TGFβ-Driven Endothelial-to-Mesenchymal Transition.
-
Tumor-specific CD8+ T cells expressing interleukin-12 eradicate established cancers in lymphodepleted hosts.
-
Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning.
-
Tumor-targeted, systemic delivery of therapeutic viral vectors using hitchhiking on antigen-specific T cells.
-
Two-photon molecular excitation imaging of Ca2+ transients in Langendorff-perfused mouse hearts.
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Type 17 CD8+ T cells display enhanced antitumor immunity.
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Type 2 alveolar cells are stem cells in adult lung.
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Type I interferon signaling restrains IL-10R+ colonic macrophages and dendritic cells and leads to more severe Salmonella colitis.
-
Type III TGF-β receptor downregulation generates an immunotolerant tumor microenvironment.
-
UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling.
-
Ubiquitous expression of mRFP1 in transgenic mice.
-
Uncoupling of G-protein coupled receptors in vivo: insights from transgenic mice.
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Uncoupling of Protein Aggregation and Neurodegeneration in a Mouse Amyotrophic Lateral Sclerosis Model.
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Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).
-
Unexpected role of clathrin adaptor AP-1 in MHC-dependent positive selection of T cells.
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Unmasking the osteoinductive effects of a G-protein-coupled receptor (GPCR) kinase (GRK) inhibitor by treatment with PTH(1-34).
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Upregulation of CD4 expression during MHC class II-specific positive selection is essential for error-free lineage choice.
-
Upregulation of miR21 and repression of Grhl3 by leptin mediates sinusoidal endothelial injury in experimental nonalcoholic steatohepatitis.
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Use of Hes1-GFP reporter mice to assess activity of the Hes1 promoter in bone cells under chronic inflammation.
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Use of genetically modified mouse models for evaluation of carcinogenic risk: considerations for the laboratory animal scientist.
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Uteroglobin: a potential novel tumor suppressor and molecular therapeutic for prostate cancer.
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Utilization of pathway signatures to reveal distinct types of B lymphoma in the Emicro-myc model and human diffuse large B-cell lymphoma.
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Utilization of the Eμ-Myc mouse to model heterogeneity of therapeutic response.
-
Vaccination with mRNAs encoding tumor-associated antigens and granulocyte-macrophage colony-stimulating factor efficiently primes CTL responses, but is insufficient to overcome tolerance to a model tumor/self antigen.
-
Vascular Type 1A Angiotensin II Receptors Control BP by Regulating Renal Blood Flow and Urinary Sodium Excretion.
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Vascular amyloid alters astrocytic water and potassium channels in mouse models and humans with Alzheimer's disease.
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Vascular-mesenchymal cross-talk through Vegf and Pdgf drives organ patterning.
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Vascular-targeted overexpression of G protein-coupled receptor kinase-2 in transgenic mice attenuates beta-adrenergic receptor signaling and increases resting blood pressure.
-
Ventricular expression of a MLC-2v-ras fusion gene induces cardiac hypertrophy and selective diastolic dysfunction in transgenic mice.
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Very low affinity B cells form germinal centers, become memory B cells, and participate in secondary immune responses when higher affinity competition is reduced.
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Viral cell death inhibitor MC159 enhances innate immunity against vaccinia virus infection.
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Visual impairment in an optineurin mouse model of primary open-angle glaucoma.
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Western-type diet modulates inflammatory responses and impairs functional outcome following permanent middle cerebral artery occlusion in aged mice expressing the human apolipoprotein E4 allele.
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Wild-Type Hras Suppresses the Earliest Stages of Tumorigenesis in a Genetically Engineered Mouse Model of Pancreatic Cancer.
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Wound healing in hemophilia B mice and low tissue factor mice.
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X-linked inhibitor of apoptosis deficiency in the TRAMP mouse prostate cancer model.
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XBP1 (X-Box-Binding Protein-1)-Dependent O-GlcNAcylation Is Neuroprotective in Ischemic Stroke in Young Mice and Its Impairment in Aged Mice Is Rescued by Thiamet-G.
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Y+ and y+ L arginine transporters in neuronal cells expressing tyrosine hydroxylase.
-
Yin Yang 1 Promotes Thymocyte Survival by Downregulating p53.
-
Yolk-sac-derived macrophages regulate fetal testis vascularization and morphogenesis.
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beta-Catenin is not necessary for maintenance or repair of the bronchiolar epithelium.
-
beta-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds.
-
c-FLIP protects eosinophils from TNF-α-mediated cell death in vivo.
-
c-FLIP protects mature T lymphocytes from TCR-mediated killing.
-
cTnT1, a cardiac troponin T isoform, decreases myofilament tension and affects the left ventricular pressure waveform.
-
cis-acting elements that confer lung epithelial cell expression of the CC10 gene.
-
iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions.
-
mNos2 deletion and human NOS2 replacement in Alzheimer disease models.
-
miR-181a is an intrinsic modulator of T cell sensitivity and selection.
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miR-33a promotes glioma-initiating cell self-renewal via PKA and NOTCH pathways.
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p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis.
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p53 functions in endothelial cells to prevent radiation-induced myocardial injury in mice.
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β-Catenin-SOX2 signaling regulates the fate of developing airway epithelium.
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β-Catenin-regulated myeloid cell adhesion and migration determine wound healing.
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β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions.
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Keywords of People
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Badea, Cristian Tudorel,
Professor in Radiology,
Biomedical Engineering
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Bennett, Vann,
George B. Geller Professor for Research in Molecular Biology in the School of Medicine,
Duke Cancer Institute
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Bowes Rickman, Catherine,
Professor of Ophthalmology,
Cell Biology
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Calakos, Nicole,
Professor in Neurology,
Duke Science & Society
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Chen, Jun,
Associate Professor of Medicine,
Duke Cancer Institute
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Choi, Steven Sok,
Associate Professor of Medicine,
Medicine, Gastroenterology
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Ciofani, Maria,
Assistant Professor of Immunology,
Immunology
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Farsiu, Sina,
Associate Professor in the Department of Biomedical Engineering,
Electrical and Computer Engineering
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Gunn, Michael Dee,
Professor of Medicine,
Immunology
-
Hanks, Brent A.,
Assistant Professor of Medicine,
Pharmacology & Cancer Biology
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Hogan, Brigid L. M.,
George Barth Geller Professor,
Cell Biology
-
Hutson, Mary Redmond,
Assistant Professor of Pediatrics,
Pediatrics, Neonatology
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Jokerst, Nan Marie,
J. A. Jones Professor of Electrical and Computer Engineering in the Edmund T. Pratt, Jr. School of Engineering,
Duke University Energy Initiative
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Kelsoe, Garnett H.,
James B. Duke Professor of Immunology,
Immunology
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Krangel, Michael S.,
Mary Bernheim Professor of Immunology,
Immunology
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Laskowitz, Daniel Todd,
Professor of Neurology,
Duke Innovation & Entrepreneurship
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McDonnell, Donald Patrick,
Chair, Department of Pharmacology & Cancer Biology,
Duke Innovation & Entrepreneurship
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McLendon, Roger Edwin,
Professor of Pathology,
Pathology
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Milano, Carmelo Alessio,
Professor of Surgery,
Surgery, Cardiovascular and Thoracic Surgery
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Nicolelis, Miguel Angelo L.,
Duke School of Medicine Professor in Neuroscience,
Biomedical Engineering
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Pitt, Geoffrey Stuart,
Adjunct Professor in the Department of Medicine,
Medicine, Cardiology
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Sampson, John Howard,
Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine,
Immunology
-
Schanberg, Laura Eve,
Professor of Pediatrics,
Pediatrics, Rheumatology
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Schmehl, Meredith,
Student,
Neurobiology
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Shinohara, Mari L.,
Associate Professor of Immunology,
Immunology
-
Silver, Debra Lynn,
Associate Professor of Molecular Genetics and Microbiology,
Duke Science & Society
-
Soderling, Scott Haydn,
Professor in Cell Biology,
Cell Biology
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Sparks, Matthew A.,
Assistant Professor of Medicine,
Medicine, Nephrology
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Sunday, Mary Elizabeth Anne,
Professor of Pathology,
Cell Biology
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Taylor, Gregory Alan,
Associate Professor in Medicine,
Immunology
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Toth, Cynthia Ann,
Joseph A.C. Wadsworth Professor of Ophthalmology,
Ophthalmology, Vitreoretinal Diseases & Surgery
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Warner, David Samuel,
Distinguished Professor of Anesthesiology, in the School of Medicine,
Neurobiology
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Yan, Hai,
Henry S. Friedman Professor of Neuro-Oncology in the School of Medicine,
Pathology
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Yang, Yiping,
Professor of Medicine,
Immunology
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Zhong, Xiaoping,
Professor of Pediatrics,
Immunology