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Subject Areas on Research
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A double-blind, randomized, multicenter phase 2 study of prasugrel versus placebo in adult patients with sickle cell disease.
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A genome-wide association study identifies novel loci for paclitaxel-induced sensory peripheral neuropathy in CALGB 40101.
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A new function for adducin. Calcium/calmodulin-regulated capping of the barbed ends of actin filaments.
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A novel fibrotic disorder associated with increased dermal fibroblast proliferation and downregulation of genes of the microfibrillar network.
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A novel missense mutation of Wilms' Tumor 1 causes autosomal dominant FSGS.
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A two-tiered mechanism by which Cdc42 controls the localization and activation of an Arp2/3-activating motor complex in yeast.
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ADF/cofilin promotes invadopodial membrane recycling during cell invasion in vivo.
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AIF-1 in the activated smooth muscle cell : spectator or participant?
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APOE Isoforms Control Pathogenic Subretinal Inflammation in Age-Related Macular Degeneration.
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Abl interactor 1 (Abi-1) wave-binding and SNARE domains regulate its nucleocytoplasmic shuttling, lamellipodium localization, and wave-1 levels.
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Abundant expression of ponsin, a focal adhesion protein, in lens and downregulation of its expression by impaired cytoskeletal signaling.
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Actin and myosin biochemistry in relation to cytokinesis.
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Actin dynamics: the arp2/3 complex branches out.
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Actin-associated neurabin-protein phosphatase-1 complex regulates hippocampal plasticity.
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Advanced magnetic resonance imaging of cerebral cavernous malformations: part II. Imaging of lesions in murine models.
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Alpha-fodrin is cleaved by caspase-3 in a chronic ocular hypertensive (COH) rat model of glaucoma.
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Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism.
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Analysis of the role of membrane polarity in polycystic kidney disease of transgenic SBM mice.
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Analyzing somatosensory axon projections with the sensory neuron-specific Advillin gene.
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Ankyrin-B interactions with spectrin and dynactin-4 are required for dystrophin-based protection of skeletal muscle from exercise injury.
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Ankyrin-B is required for coordinated expression of beta-2-spectrin, the Na/K-ATPase and the Na/Ca exchanger in the inner segment of rod photoreceptors.
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Ankyrin-G is a molecular partner of E-cadherin in epithelial cells and early embryos.
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Assessment of clopidogrel responsiveness: measurements of maximum platelet aggregation, final platelet aggregation and their correlation with vasodilator-stimulated phosphoprotein in resistant patients.
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Association of the PHACTR1/EDN1 Genetic Locus With Spontaneous Coronary Artery Dissection.
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Axonal regrowth after spinal cord injury via chondroitinase and the tissue plasminogen activator (tPA)/plasmin system.
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Balancing different types of actin polymerization at distinct sites: roles for Abelson kinase and Enabled.
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Binding of activated alpha2-macroglobulin to its cell surface receptor GRP78 in 1-LN prostate cancer cells regulates PAK-2-dependent activation of LIMK.
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Brain region-specific disruption of Shank3 in mice reveals a dissociation for cortical and striatal circuits in autism-related behaviors.
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Calcium-sensing receptor activation of rho involves filamin and rho-guanine nucleotide exchange factor.
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Calmodulin dissociation regulates Myo5 recruitment and function at endocytic sites.
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Cdc42p regulation of the yeast formin Bni1p mediated by the effector Gic2p.
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Cell motility as a prognostic factor in Stage I nonsmall cell lung carcinoma: the role of gelsolin expression.
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Characterization of a gene trap insertion into a novel gene, cordon-bleu, expressed in axial structures of the gastrulating mouse embryo.
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Characterization of lens fiber cell triton insoluble fraction reveals ERM (ezrin, radixin, moesin) proteins as major cytoskeletal-associated proteins.
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Characterization of moesin in the sea urchin Lytechinus variegatus: redistribution to the plasma membrane following fertilization is inhibited by cytochalasin B.
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Clinical significance of tumor-associated inflammatory cells in metastatic neuroblastoma.
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Common variants near ABCA1, AFAP1 and GMDS confer risk of primary open-angle glaucoma.
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Control of electrolyte balance through ubiquitination.
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Cordon-bleu is a conserved gene involved in neural tube formation.
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Cordon-bleu is an actin nucleation factor and controls neuronal morphology.
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Decrease in high on-treatment platelet reactivity (HPR) prevalence on switching from clopidogrel to prasugrel: insights from the switching anti-platelet (SWAP) study.
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Developmental regulation of lymphocyte-specific protein 1 (LSP1) expression in thymus during human T-cell maturation.
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Differential effects of platelet-derived growth factor isotypes on human smooth muscle cell proliferation and migration are mediated by distinct signaling pathways.
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Differentiation- and stress-dependent nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling protein.
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Direct involvement of yeast type I myosins in Cdc42-dependent actin polymerization.
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Double mutant fibrillin-1 (FBN1) allele in a patient with neonatal Marfan syndrome.
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Downregulation of TSLC1 and DAL-1 expression occurs frequently in breast cancer.
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Dual labeling of the fibronectin matrix and actin cytoskeleton with green fluorescent protein variants.
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Dual labeling of the fibronectin matrix and actin cytoskeleton with green fluorescent protein variants.
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Dynamic positioning of mitotic spindles in yeast: role of microtubule motors and cortical determinants.
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Effect of adjunctive dipyridamole to DAPT on platelet function profiles in stented patients with high platelet reactivity. The result of the ACCEL-DIP Study.
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Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix.
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Error-prone polyploid mitosis during normal Drosophila development.
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Exome analysis of two limb-girdle muscular dystrophy families: mutations identified and challenges encountered.
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Expression of functional domains of beta G-spectrin disrupts epithelial morphology in cultured cells.
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Fascin regulates prostate cancer cell invasion and is associated with metastasis and biochemical failure in prostate cancer.
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Fluoxetine treatment prevents the inflammatory response in a mouse model of posttraumatic stress disorder.
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Forces drive basement membrane invasion in Caenorhabditis elegans
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Functional roles of VASP phosphorylation in the regulation of chemotaxis and osmotic stress response.
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G protein-coupled receptor kinase regulates dopamine D3 receptor signaling by modulating the stability of a receptor-filamin-beta-arrestin complex. A case of autoreceptor regulation.
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GFP-moesin illuminates actin cytoskeleton dynamics in living tissue and demonstrates cell shape changes during morphogenesis in Drosophila.
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Genome-Wide Association Study to Identify Susceptibility Loci That Modify Radiation-Related Risk for Breast Cancer After Childhood Cancer.
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Genome-wide association study of sepsis in extremely premature infants.
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Genome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic epidemiology network (COGENT).
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HIV-1 Nef induces dedifferentiation of podocytes in vivo: a characteristic feature of HIVAN.
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HIV-1 induces renal epithelial dedifferentiation in a transgenic model of HIV-associated nephropathy.
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High on-treatment platelet reactivity assessed by various platelet function tests: is the consensus-defined cut-off of VASP-P platelet reactivity index too low?
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Hyperadhesive mutant of type 1-fimbriated Escherichia coli associated with formation of FimH organelles (fimbriosomes).
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Identification of Drosophila cytoskeletal proteins by induction of abnormal cell shape in fission yeast.
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Identification of a novel gene linked to parkin via a bi-directional promoter.
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Impaired monocyte cholesterol clearance initiates age-related retinal degeneration and vision loss.
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In vitro reconstitution of cortical actin assembly sites in budding yeast.
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In vivo dynamics of clathrin and its adaptor-dependent recruitment to the actin-based endocytic machinery in yeast.
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In vivo electroporation and non-protein based screening assays to identify antibodies against native protein conformations.
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In vivo proximity proteomics of nascent synapses reveals a novel regulator of cytoskeleton-mediated synaptic maturation.
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Induction of spine growth and synapse formation by regulation of the spine actin cytoskeleton.
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Inflammation-associated repression of vasodilator-stimulated phosphoprotein (VASP) reduces alveolar-capillary barrier function during acute lung injury.
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Influence of platelet reactivity on BARC classification in East Asian patients undergoing percutaneous coronary intervention. Results of the ACCEL-BLEED study.
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Interaction of NG2(+) glial progenitors and microglia/macrophages from the injured spinal cord.
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Inverted formin 2 mutations with variable expression in patients with sporadic and hereditary focal and segmental glomerulosclerosis.
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Juvenile bilateral lens dislocation and glaucoma associated with a novel mutation in the fibrillin 1 gene.
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Laser-scanning velocimetry: a confocal microscopy method for quantitative measurement of cardiovascular performance in zebrafish embryos and larvae.
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Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice.
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Loss of phosphatase and tensin homologue increases transforming growth factor beta-mediated invasion with enhanced SMAD3 transcriptional activity.
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Mechanism for G2 phase-specific nuclear export of the kinetochore protein CENP-F.
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Mechanisms of the proteinuria induced by Rho GTPases.
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Microcell-mediated chromosome transfer identifies EPB41L3 as a functional suppressor of epithelial ovarian cancers.
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Microglia: a promising target for treating neuropathic and postoperative pain, and morphine tolerance.
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Modulation of microfilament protein composition by transfected cytoskeletal actin genes.
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Mutations in filamin 1 prevent migration of cerebral cortical neurons in human periventricular heterotopia.
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Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities.
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Mutations in the gene that encodes the F-actin binding protein anillin cause FSGS.
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Myotilin is mutated in limb girdle muscular dystrophy 1A.
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Myotilin is not the causative gene for vocal cord and pharyngeal weakness with distal myopathy (VCPDM).
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Myotilin overexpression enhances myopathology in the LGMD1A mouse model.
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NHERF1/EBP50 is an organizer of polarity structures and a diagnostic marker in ependymoma.
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Neurabin/protein phosphatase-1 complex regulates dendritic spine morphogenesis and maturation.
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Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton.
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Neuronal expression of the Ccm2 gene in a new mouse model of cerebral cavernous malformations.
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Neuropathology in respiratory-related motoneurons in young Pompe (Gaa(-/-)) mice.
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Neutrophil L-Plastin Controls Ocular Paucibacteriality and Susceptibility to Keratitis.
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Novel variants in SPTAN1 without epilepsy: An expansion of the phenotype.
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Nucleotide sequence, expression, and chromosomal mapping of Mrp and mapping of five related sequences.
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Ophthalmic genetics/inherited eye disease.
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Orthopedic surgery modulates neuropeptides and BDNF expression at the spinal and hippocampal levels.
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Palladin is an actin cross-linking protein that uses immunoglobulin-like domains to bind filamentous actin.
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Periaxin is required for hexagonal geometry and membrane organization of mature lens fibers.
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Periventricular nodular heterotopia in patients with filamin-1 gene mutations: neuroimaging findings.
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Phenotypic characterization of murine models of cerebral cavernous malformations.
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Podocyte cell cycle regulation and proliferation in collapsing glomerulopathies.
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Protein phosphatase 1 regulation by inhibitors and targeting subunits.
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Proteomic analysis of radiation-induced changes in rat lung: Modulation by the superoxide dismutase mimetic MnTE-2-PyP(5+).
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Quantification of cell edge velocities and traction forces reveals distinct motility modules during cell spreading.
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Rapid de-localization of actin leading edge components with BDM treatment.
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Real-time imaging of morphogenetic movements in Drosophila using Gal4-UAS-driven expression of GFP fused to the actin-binding domain of moesin.
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Reduction of Stat3 activity attenuates HIV-induced kidney injury.
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Regulation of cell-cell adhesion by Abi/Diaphanous complexes.
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Regulation of synaptic strength by protein phosphatase 1.
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Relation between the vasodilator-stimulated phosphoprotein phosphorylation assay and light transmittance aggregometry in East Asian patients after high-dose clopidogrel loading.
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Requirement of a vasodilator-stimulated phosphoprotein family member for cell adhesion, the formation of filopodia, and chemotaxis in dictyostelium.
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Response to ticagrelor in clopidogrel nonresponders and responders and effect of switching therapies: the RESPOND study.
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Revisiting the mystery of fibronectin multimers: the fibronectin matrix is composed of fibronectin dimers cross-linked by non-covalent bonds.
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Role of VASP phosphorylation for the regulation of microglia chemotaxis via the regulation of focal adhesion formation/maturation.
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Roles of protein kinase C and actin-binding protein 280 in the regulation of intracellular trafficking of dopamine D3 receptor.
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SHANK3 Deficiency Impairs Heat Hyperalgesia and TRPV1 Signaling in Primary Sensory Neurons.
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Saccharomyces cerevisiae Bzz1p is implicated with type I myosins in actin patch polarization and is able to recruit actin-polymerizing machinery in vitro.
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Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
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Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold.
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Select de novo gene and protein expression during renal epithelial cell culture in rotating wall vessels is shear stress dependent.
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Sex-Specific Effects of Progesterone on Early Outcome of Intracerebral Hemorrhage.
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Shank3 mutant mice display autistic-like behaviours and striatal dysfunction.
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Spinal injection of TNF-α-activated astrocytes produces persistent pain symptom mechanical allodynia by releasing monocyte chemoattractant protein-1.
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Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors.
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Statistical characterization of protein ensembles.
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Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3.
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Syndecan-1 regulates vascular smooth muscle cell phenotype.
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Targeting protein phosphatase 1 (PP1) to the actin cytoskeleton: the neurabin I/PP1 complex regulates cell morphology.
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Temporal control of gene deletion in sensory ganglia using a tamoxifen-inducible Advillin-Cre-ERT2 recombinase mouse.
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The Drosophila afadin homologue Canoe regulates linkage of the actin cytoskeleton to adherens junctions during apical constriction.
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The Human FSGS-Causing ANLN R431C Mutation Induces Dysregulated PI3K/AKT/mTOR/Rac1 Signaling in Podocytes.
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The KASH domain protein MSP-300 plays an essential role in nuclear anchoring during Drosophila oogenesis.
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The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling.
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The actin membrane skeleton in Drosophila development.
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The actin nucleator Cordon-bleu is required for development of motile cilia in zebrafish.
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The dysregulated podocyte phenotype: a novel concept in the pathogenesis of collapsing idiopathic focal segmental glomerulosclerosis and HIV-associated nephropathy.
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The effect of elinogrel on high platelet reactivity during dual antiplatelet therapy and the relation to CYP2C19*2 genotype: first experience in patients.
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The identification of a second actin-binding region in spinophilin/neurabin II.
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The junctional complex of the membrane skeleton.
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The neuronal actin-binding proteins, neurabin I and neurabin II, recruit specific isoforms of protein phosphatase-1 catalytic subunits.
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The role of actin in spindle orientation changes during the Saccharomyces cerevisiae cell cycle.
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The role of the calponin homology domain of smoothelin-like 1 (SMTNL1) in myosin phosphatase inhibition and smooth muscle contraction.
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The role of β-arrestin2-dependent signaling in thoracic aortic aneurysm formation in a murine model of Marfan syndrome.
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Transdifferentiation of human endothelial progenitors into smooth muscle cells.
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Transgelin-2 as a therapeutic target for asthmatic pulmonary resistance.
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Transgelin-2: Biochemical and Clinical Implications in Cancer and Asthma.
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Transgenic mice expressing the myotilin T57I mutation unite the pathology associated with LGMD1A and MFM.
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Traumatic brain injury-induced neuronal damage in the somatosensory cortex causes formation of rod-shaped microglia that promote astrogliosis and persistent neuroinflammation.
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Vapor detection and discrimination with a panel of odorant receptors.
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Wsp1 is downstream of Cin1 and regulates vesicle transport and actin cytoskeleton as an effector of Cdc42 and Rac1 in Cryptococcus neoformans.
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alpha-Crystallin localizes to the leading edges of migrating lens epithelial cells.
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myotilin Mutation found in second pedigree with LGMD1A.
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p53-dependent induction of heat shock protein 27 (HSP27) expression.
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α-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration.
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Keywords of People
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Bennett, Vann,
George Barth Geller Distinguished Professor of Molecular Biology,
Duke Cancer Institute
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Berchuck, Andrew,
James M. Ingram Distinguished Professor of Gynecologic Oncology,
Obstetrics and Gynecology, Gynecologic Oncology
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Soderling, Scott Haydn,
George Barth Geller Distinguished Professor of Molecular Biology,
Cell Biology