Microfilament Proteins

• 

  Subject Areas on Research

  • A double-blind, randomized, multicenter phase 2 study of prasugrel versus placebo in adult patients with sickle cell disease. 
  • A genome-wide association study identifies novel loci for paclitaxel-induced sensory peripheral neuropathy in CALGB 40101. 
  • A new function for adducin. Calcium/calmodulin-regulated capping of the barbed ends of actin filaments. 
  • A novel fibrotic disorder associated with increased dermal fibroblast proliferation and downregulation of genes of the microfibrillar network. 
  • A novel missense mutation of Wilms' Tumor 1 causes autosomal dominant FSGS. 
  • A reciprocal tensin-3-cten switch mediates EGF-driven mammary cell migration. 
  • A two-tiered mechanism by which Cdc42 controls the localization and activation of an Arp2/3-activating motor complex in yeast. 
  • ADF/cofilin promotes invadopodial membrane recycling during cell invasion in vivo. 
  • AIF-1 in the activated smooth muscle cell : spectator or participant? 
  • APOE Isoforms Control Pathogenic Subretinal Inflammation in Age-Related Macular Degeneration. 
  • Abl interactor 1 (Abi-1) wave-binding and SNARE domains regulate its nucleocytoplasmic shuttling, lamellipodium localization, and wave-1 levels. 
  • Abundant expression of ponsin, a focal adhesion protein, in lens and downregulation of its expression by impaired cytoskeletal signaling. 
  • Actin and myosin biochemistry in relation to cytokinesis. 
  • Actin dynamics: the arp2/3 complex branches out. 
  • Actin-associated neurabin-protein phosphatase-1 complex regulates hippocampal plasticity. 
  • Advanced magnetic resonance imaging of cerebral cavernous malformations: part II. Imaging of lesions in murine models. 
  • Alpha-fodrin is cleaved by caspase-3 in a chronic ocular hypertensive (COH) rat model of glaucoma. 
  • Analysis of the role of membrane polarity in polycystic kidney disease of transgenic SBM mice. 
  • Analyzing somatosensory axon projections with the sensory neuron-specific Advillin gene. 
  • Ankyrin-B interactions with spectrin and dynactin-4 are required for dystrophin-based protection of skeletal muscle from exercise injury. 
  • Ankyrin-B is required for coordinated expression of beta-2-spectrin, the Na/K-ATPase and the Na/Ca exchanger in the inner segment of rod photoreceptors. 
  • Ankyrin-G is a molecular partner of E-cadherin in epithelial cells and early embryos. 
  • Assessment of clopidogrel responsiveness: measurements of maximum platelet aggregation, final platelet aggregation and their correlation with vasodilator-stimulated phosphoprotein in resistant patients. 
  • Association of the PHACTR1/EDN1 Genetic Locus With Spontaneous Coronary Artery Dissection. 
  • Axonal regrowth after spinal cord injury via chondroitinase and the tissue plasminogen activator (tPA)/plasmin system. 
  • Balancing different types of actin polymerization at distinct sites: roles for Abelson kinase and Enabled. 
  • Binding of activated alpha2-macroglobulin to its cell surface receptor GRP78 in 1-LN prostate cancer cells regulates PAK-2-dependent activation of LIMK. 
  • Brain radiation injury leads to a dose- and time-dependent recruitment of peripheral myeloid cells that depends on CCR2 signaling. 
  • Calcium-sensing receptor activation of rho involves filamin and rho-guanine nucleotide exchange factor. 
  • Calmodulin dissociation regulates Myo5 recruitment and function at endocytic sites. 
  • Cardiac neural crest is necessary for normal addition of the myocardium to the arterial pole from the secondary heart field. 
  • Cdc42p regulation of the yeast formin Bni1p mediated by the effector Gic2p. 
  • Cell motility as a prognostic factor in Stage I nonsmall cell lung carcinoma: the role of gelsolin expression. 
  • Characterization of lens fiber cell triton insoluble fraction reveals ERM (ezrin, radixin, moesin) proteins as major cytoskeletal-associated proteins. 
  • Characterization of moesin in the sea urchin Lytechinus variegatus: redistribution to the plasma membrane following fertilization is inhibited by cytochalasin B. 
  • Clinical significance of tumor-associated inflammatory cells in metastatic neuroblastoma. 
  • Common variants near ABCA1, AFAP1 and GMDS confer risk of primary open-angle glaucoma. 
  • Complex pattern of interaction between in utero hypoxia-ischemia and intra-amniotic inflammation disrupts brain development and motor function. 
  • Decrease in high on-treatment platelet reactivity (HPR) prevalence on switching from clopidogrel to prasugrel: insights from the switching anti-platelet (SWAP) study. 
  • Developmental regulation of lymphocyte-specific protein 1 (LSP1) expression in thymus during human T-cell maturation. 
  • Differential effects of platelet-derived growth factor isotypes on human smooth muscle cell proliferation and migration are mediated by distinct signaling pathways. 
  • Differentiation- and stress-dependent nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling protein. 
  • Direct involvement of yeast type I myosins in Cdc42-dependent actin polymerization. 
  • Double mutant fibrillin-1 (FBN1) allele in a patient with neonatal Marfan syndrome. 
  • Downregulation of TSLC1 and DAL-1 expression occurs frequently in breast cancer. 
  • Dual labeling of the fibronectin matrix and actin cytoskeleton with green fluorescent protein variants. 
  • Dual labeling of the fibronectin matrix and actin cytoskeleton with green fluorescent protein variants. 
  • Dynamic positioning of mitotic spindles in yeast: role of microtubule motors and cortical determinants. 
  • Effect of adjunctive dipyridamole to DAPT on platelet function profiles in stented patients with high platelet reactivity. The result of the ACCEL-DIP Study. 
  • Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix. 
  • Error-prone polyploid mitosis during normal Drosophila development. 
  • Exome analysis of two limb-girdle muscular dystrophy families: mutations identified and challenges encountered. 
  • Expression of functional domains of beta G-spectrin disrupts epithelial morphology in cultured cells. 
  • Fascin regulates prostate cancer cell invasion and is associated with metastasis and biochemical failure in prostate cancer. 
  • Fluoxetine treatment prevents the inflammatory response in a mouse model of posttraumatic stress disorder. 
  • Forces drive basement membrane invasion in Caenorhabditis elegans. 
  • G protein-coupled receptor kinase regulates dopamine D3 receptor signaling by modulating the stability of a receptor-filamin-beta-arrestin complex. A case of autoreceptor regulation. 
  • GFP-moesin illuminates actin cytoskeleton dynamics in living tissue and demonstrates cell shape changes during morphogenesis in Drosophila. 
  • Gene expression in temporal lobe epilepsy is consistent with increased release of glutamate by astrocytes. 
  • Genome-Wide Association Study to Identify Susceptibility Loci That Modify Radiation-Related Risk for Breast Cancer After Childhood Cancer. 
  • Genome-wide association study of sepsis in extremely premature infants. 
  • Genome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic epidemiology network (COGENT). 
  • Growth factor receptors, phospholipases, phospholipid kinases and actin reorganization. 
  • HIV-1 Nef induces dedifferentiation of podocytes in vivo: a characteristic feature of HIVAN. 
  • HIV-1 induces renal epithelial dedifferentiation in a transgenic model of HIV-associated nephropathy. 
  • High on-treatment platelet reactivity assessed by various platelet function tests: is the consensus-defined cut-off of VASP-P platelet reactivity index too low? 
  • Hyperadhesive mutant of type 1-fimbriated Escherichia coli associated with formation of FimH organelles (fimbriosomes). 
  • Identification of Drosophila cytoskeletal proteins by induction of abnormal cell shape in fission yeast. 
  • Identification of protein marker in vaginal wall tissues of women with stress urinary incontinence by protein chip array. 
  • Impaired monocyte cholesterol clearance initiates age-related retinal degeneration and vision loss. 
  • In vitro reconstitution of cortical actin assembly sites in budding yeast. 
  • In vivo dynamics of clathrin and its adaptor-dependent recruitment to the actin-based endocytic machinery in yeast. 
  • In vivo electroporation and non-protein based screening assays to identify antibodies against native protein conformations. 
  • In vivo proximity proteomics of nascent synapses reveals a novel regulator of cytoskeleton-mediated synaptic maturation. 
  • Induction of spine growth and synapse formation by regulation of the spine actin cytoskeleton. 
  • Inflammation-associated repression of vasodilator-stimulated phosphoprotein (VASP) reduces alveolar-capillary barrier function during acute lung injury. 
  • Influence of platelet reactivity on BARC classification in East Asian patients undergoing percutaneous coronary intervention. Results of the ACCEL-BLEED study. 
  • Interaction of NG2(+) glial progenitors and microglia/macrophages from the injured spinal cord. 
  • Inverted formin 2 mutations with variable expression in patients with sporadic and hereditary focal and segmental glomerulosclerosis. 
  • Juvenile bilateral lens dislocation and glaucoma associated with a novel mutation in the fibrillin 1 gene. 
  • KANK deficiency leads to podocyte dysfunction and nephrotic syndrome. 
  • Laser-scanning velocimetry: a confocal microscopy method for quantitative measurement of cardiovascular performance in zebrafish embryos and larvae. 
  • Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice. 
  • Loss of phosphatase and tensin homologue increases transforming growth factor beta-mediated invasion with enhanced SMAD3 transcriptional activity. 
  • Mechanism for G2 phase-specific nuclear export of the kinetochore protein CENP-F. 
  • Mechanisms of the proteinuria induced by Rho GTPases. 
  • Microcell-mediated chromosome transfer identifies EPB41L3 as a functional suppressor of epithelial ovarian cancers. 
  • Microglia: a promising target for treating neuropathic and postoperative pain, and morphine tolerance. 
  • Modulation of microfilament protein composition by transfected cytoskeletal actin genes. 
  • Mutations in filamin 1 prevent migration of cerebral cortical neurons in human periventricular heterotopia. 
  • Mutations in the gene that encodes the F-actin binding protein anillin cause FSGS. 
  • NHERF1/EBP50 is an organizer of polarity structures and a diagnostic marker in ependymoma. 
  • Neurabin/protein phosphatase-1 complex regulates dendritic spine morphogenesis and maturation. 
  • Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton. 
  • Neuronal expression of the Ccm2 gene in a new mouse model of cerebral cavernous malformations. 
  • Neuropathology in respiratory-related motoneurons in young Pompe (Gaa(-/-)) mice. 
  • Novel variants in SPTAN1 without epilepsy: An expansion of the phenotype. 
  • Ophthalmic genetics/inherited eye disease. 
  • Orthopedic surgery modulates neuropeptides and BDNF expression at the spinal and hippocampal levels. 
  • Palladin is an actin cross-linking protein that uses immunoglobulin-like domains to bind filamentous actin. 
  • Periaxin is required for hexagonal geometry and membrane organization of mature lens fibers. 
  • Periventricular nodular heterotopia in patients with filamin-1 gene mutations: neuroimaging findings. 
  • Phenotypic characterization of murine models of cerebral cavernous malformations. 
  • Podocyte cell cycle regulation and proliferation in collapsing glomerulopathies. 
  • Primary blast injury causes cognitive impairments and hippocampal circuit alterations. 
  • Protein phosphatase 1 regulation by inhibitors and targeting subunits. 
  • Proteomic analysis of radiation-induced changes in rat lung: Modulation by the superoxide dismutase mimetic MnTE-2-PyP(5+). 
  • Quantification of cell edge velocities and traction forces reveals distinct motility modules during cell spreading. 
  • Rapid de-localization of actin leading edge components with BDM treatment. 
  • Real-time imaging of morphogenetic movements in Drosophila using Gal4-UAS-driven expression of GFP fused to the actin-binding domain of moesin. 
  • Reduction of Stat3 activity attenuates HIV-induced kidney injury. 
  • Regulation of cell-cell adhesion by Abi/Diaphanous complexes. 
  • Regulation of synaptic strength by protein phosphatase 1. 
  • Relation between the vasodilator-stimulated phosphoprotein phosphorylation assay and light transmittance aggregometry in East Asian patients after high-dose clopidogrel loading. 
  • Response to ticagrelor in clopidogrel nonresponders and responders and effect of switching therapies: the RESPOND study. 
  • Revisiting the mystery of fibronectin multimers: the fibronectin matrix is composed of fibronectin dimers cross-linked by non-covalent bonds. 
  • Roles of protein kinase C and actin-binding protein 280 in the regulation of intracellular trafficking of dopamine D3 receptor. 
  • Saccharomyces cerevisiae Bzz1p is implicated with type I myosins in actin patch polarization and is able to recruit actin-polymerizing machinery in vitro. 
  • Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold. 
  • Select de novo gene and protein expression during renal epithelial cell culture in rotating wall vessels is shear stress dependent. 
  • Sex-Specific Effects of Progesterone on Early Outcome of Intracerebral Hemorrhage. 
  • Spinal injection of TNF-α-activated astrocytes produces persistent pain symptom mechanical allodynia by releasing monocyte chemoattractant protein-1. 
  • Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors. 
  • Statistical characterization of protein ensembles. 
  • Targeting protein phosphatase 1 (PP1) to the actin cytoskeleton: the neurabin I/PP1 complex regulates cell morphology. 
  • Temporal control of gene deletion in sensory ganglia using a tamoxifen-inducible Advillin-Cre-ERT2 recombinase mouse. 
  • The Drosophila afadin homologue Canoe regulates linkage of the actin cytoskeleton to adherens junctions during apical constriction. 
  • The Human FSGS-Causing ANLN R431C Mutation Induces Dysregulated PI3K/AKT/mTOR/Rac1 Signaling in Podocytes. 
  • The KASH domain protein MSP-300 plays an essential role in nuclear anchoring during Drosophila oogenesis. 
  • The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling. 
  • The actin membrane skeleton in Drosophila development. 
  • The actin nucleator Cordon-bleu is required for development of motile cilia in zebrafish. 
  • The dysregulated podocyte phenotype: a novel concept in the pathogenesis of collapsing idiopathic focal segmental glomerulosclerosis and HIV-associated nephropathy. 
  • The effect of elinogrel on high platelet reactivity during dual antiplatelet therapy and the relation to CYP2C19*2 genotype: first experience in patients. 
  • The identification of a second actin-binding region in spinophilin/neurabin II. 
  • The junctional complex of the membrane skeleton. 
  • The kinetochore protein, CENPF, is mutated in human ciliopathy and microcephaly phenotypes. 
  • The neuronal actin-binding proteins, neurabin I and neurabin II, recruit specific isoforms of protein phosphatase-1 catalytic subunits. 
  • The role of actin in spindle orientation changes during the Saccharomyces cerevisiae cell cycle. 
  • The role of the calponin homology domain of smoothelin-like 1 (SMTNL1) in myosin phosphatase inhibition and smooth muscle contraction. 
  • The role of β-arrestin2-dependent signaling in thoracic aortic aneurysm formation in a murine model of Marfan syndrome. 
  • Transdifferentiation of human endothelial progenitors into smooth muscle cells. 
  • Vapor detection and discrimination with a panel of odorant receptors. 
  • Wsp1 is downstream of Cin1 and regulates vesicle transport and actin cytoskeleton as an effector of Cdc42 and Rac1 in Cryptococcus neoformans. 
  • alpha-Crystallin localizes to the leading edges of migrating lens epithelial cells. 
  • p53-dependent induction of heat shock protein 27 (HSP27) expression. 
  • α-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration. 
• 

  Keywords of People

  • Bennett, Vann, George B. Geller Distinguished Professor for Research in Molecular Biology in the School of Medicine, Duke Cancer Institute
  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Soderling, Scott Haydn, Professor in Cell Biology, Cell Biology