Microinjections

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  Subject Areas on Research

  • A GABAergic nigrotectal pathway for coordination of drinking behavior. 
  • A High-Throughput Organoid Microinjection Platform to Study Gastrointestinal Microbiota and Luminal Physiology. 
  • A comparative analysis of embryo implantation potential in patients with severe teratozoospermia undergoing in-vitro fertilization with a high insemination concentration or intracytoplasmic sperm injection. 
  • A high-precision contrast injector for small animal x-ray digital subtraction angiography. 
  • ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage. 
  • Abnormal cerebellar signaling induces dystonia in mice. 
  • Actin and myosin function in acanthamoeba. 
  • Adeno-associated virus-mediated ILK gene silencing in the rat NAc core. 
  • Anatomically dissociable effects of dopamine D1 receptor agonists on reward and relief of withdrawal in morphine-dependent rats. 
  • Bilateral integration of whisker information in the primary somatosensory cortex of rats. 
  • Chronic underactivity of medial frontal cortical beta2-containing nicotinic receptors increases clozapine-induced working memory impairment in female rats. 
  • Comparison of intratumoral bolus injection and convection-enhanced delivery of radiolabeled antitenascin monoclonal antibodies. 
  • Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity 
  • DVR-4 (bone morphogenetic protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction. 
  • Differential regulation of MeCP2 phosphorylation in the CNS by dopamine and serotonin. 
  • Dorsomedial/Perifornical hypothalamic stimulation increases intraocular pressure, intracranial pressure, and the translaminar pressure gradient. 
  • Early-life experience decreases drug-induced reinstatement of morphine CPP in adulthood via microglial-specific epigenetic programming of anti-inflammatory IL-10 expression. 
  • Effective spread and timecourse of neural inactivation caused by lidocaine injection in monkey cerebral cortex. 
  • Evidence implicating alpha-2 adrenergic receptors in the anticonvulsant action of intranigral muscimol. 
  • Evidence implicating substantia nigra in regulation of kindled seizure threshold. 
  • Evolutionary modification of cell lineage in the direct-developing sea urchin Heliocidaris erythrogramma. 
  • Excitatory and inhibitory circuitry in the superficial gray layer of the superior colliculus. 
  • Experience with subzonal insemination (SUZI) and intracytoplasmic sperm injection (ICSI) on unfertilized aged human oocytes. 
  • Fast and slow gating of sodium channels encoded by a single mRNA. 
  • Features of programmed cell death in intact Xenopus oocytes and early embryos revealed by near-infrared fluorescence and real-time monitoring. 
  • Fetal antisense oligonucleotide therapy for congenital deafness and vestibular dysfunction. 
  • Frog oocytes synthesize and completely process the precursor polypeptide to virion structural proteins after microinjection of avian myeloblastosis virus RNA. 
  • Intracisternal injection of pancreatic polypeptide stimulates gastric emptying in rats. 
  • Intracytoplasmic sperm injection: achievement of high pregnancy rates in couples with severe male factor infertility is dependent primarily upon female and not male factors. 
  • Intranigral dynorphin-1-13 suppresses kindled seizures by a naloxone-insensitive mechanism. 
  • Intrinsic connections of macaque striate cortex: axonal projections of cells outside lamina 4C. 
  • Laser-scanning velocimetry: a confocal microscopy method for quantitative measurement of cardiovascular performance in zebrafish embryos and larvae. 
  • Late intracytoplasmic sperm injection in unexpected failed fertilization in vitro: diagnostic or therapeutic? 
  • Lung perfusion imaging in small animals using 4D micro-CT at heartbeat temporal resolution. 
  • Microinjection of a 19-kDa guanine nucleotide-binding protein inhibits maturation of Xenopus oocytes. 
  • Microinjection of a benzodiazepine into substantia nigra elevates kindled seizure threshold. 
  • Microinjection of echinoderm eggs: apparatus and procedures. 
  • Microinjection of muscimol into entopeduncular nucleus suppresses pilocarpine but not maximal electroshock seizures in rats. 
  • Nuclear beta-catenin is required to specify vegetal cell fates in the sea urchin embryo. 
  • Nuclear beta-catenin-dependent Wnt8 signaling in vegetal cells of the early sea urchin embryo regulates gastrulation and differentiation of endoderm and mesodermal cell lineages. 
  • Optical coherence tomography guided microinjections in live mouse embryos: high-resolution targeted manipulation for mouse embryonic research. 
  • Optimizing gene transfer to conventional outflow cells in living mouse eyes. 
  • Pancreatic polypeptide microinjection into the dorsal motor nucleus inhibits pancreatic secretion in rats. 
  • Percutaneous epididymal sperm aspiration and intracytoplasmic sperm injection in the management of infertility due to obstructive azoospermia. 
  • Perturbations to the hedgehog pathway in sea urchin embryos. 
  • Pharmacogenomic effects of apolipoprotein e on intracerebral hemorrhage. 
  • Piezo-assisted nuclear transfer affects cloning efficiency and may cause apoptosis. 
  • Pregnancy following transfer of ooplasm from cryopreserved-thawed donor oocytes into recipient oocytes. 
  • Reciprocal connections between the zona incerta and the pretectum and superior colliculus of the cat. 
  • Regulation of cell cycle progression and nuclear affinity of the retinoblastoma protein by protein phosphatases. 
  • Safety/feasibility of targeting the substantia nigra with AAV2-neurturin in Parkinson patients. 
  • Selective suppression of in vitro electrographic seizures by low-dose tetrodotoxin: a novel anticonvulsant effect. 
  • Semen quality: is there a paternal effect on pregnancy outcome in in-vitro fertilization/intracytoplasmic sperm injection? 
  • Serotonin depletion exacerbates changes in striatal gene expression following quinolinic acid injection. 
  • Simultaneous monitoring of tissue PO2 and NADH fluorescence during synaptic stimulation and spreading depression reveals a transient dissociation between oxygen utilization and mitochondrial redox state in rat hippocampal slices. 
  • Studies on the in vivo sensitivity of spindle microtubules to calcium ions and evidence for a vesicular calcium-sequestering system. 
  • Study of host-microbe interactions in zebrafish. 
  • The NMDA receptor M3 segment is a conserved transduction element coupling ligand binding to channel opening. 
  • The action of hydrogen peroxide on paired pulse and long-term potentiation in the hippocampus. 
  • The mouse Snrpn minimal promoter and its human orthologue: activity and imprinting. 
  • The outcome of clinical pregnancies following intracytoplasmic sperm injection is not affected by semen quality. 
  • The regulation of primary mesenchyme cell migration in the sea urchin embryo: transplantations of cells and latex beads. 
  • The sources of the nigrotectal pathway. 
  • The ventral hippocampal muscarinic cholinergic system plays a key role in sexual dimorphisms of spatial working memory in rats. 
  • Tissue-specific expression of the rat androgen-binding protein/sex hormone-binding globulin gene in transgenic mice. 
  • Toxicity of L-proline toward rat hippocampal neurons. 
  • Transgene expression in zebrafish: A comparison of retroviral-vector and DNA-injection approaches. 
  • Viable Mice with Extensive Gene Humanization (25-kbp) Created Using Embryonic Stem Cell/Blastocyst and CRISPR/Zygote Injection Approaches. 
  • What the brain stem tells the frontal cortex. II. Role of the SC-MD-FEF pathway in corollary discharge. 
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  Keywords of People

  • Badea, Cristian Tudorel, Professor in Radiology, Biomedical Engineering
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Biomedical Engineering