Microscopy

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  Subject Areas on Research

  • 3-Dimensional visualization of lesions in rat brain using magnetic resonance imaging microscopy. 
  • 4D in vivo imaging of glomerular barrier function in a zebrafish podocyte injury model. 
  • A compact near-field scanning optical microscope 
  • A comparison of absorbable and nonabsorbable sutures to vascular response in immature arteries. 
  • A comparison of retinal morphology viewed by optical coherence tomography and by light microscopy. 
  • A high-temperature superconducting Helmholtz probe for microscopy at 9.4 T. 
  • A new in vivo method for quantitative analysis of stroke lesions using diffusion-weighted magnetic resonance microscopy. 
  • A phase space model of Fourier ptychographic microscopy. 
  • A probe for specimen magnetic resonance microscopy. 
  • A suspicious facial lesion - A unique opportunity to test the north Carolina laboratory response network 
  • Accelerating discovery in 3D microanalysis: Leveraging open source software and deskside high performance computing 
  • Active machine learning method for identification of cell types in multiplex-stained histopathology specimens imaged by multi-spectral microscopy 
  • Active staining of mouse embryos for magnetic resonance microscopy. 
  • Amicrobial Pustulosis of the Folds and Autoimmunity. 
  • An Automated High-throughput Array Microscope for Cancer Cell Mechanics. 
  • Analysis of vaginal microbicide film hydration kinetics by quantitative imaging refractometry. 
  • Anisotropic analysis of multi-component T2 and T1ρ relaxations in achilles tendon by NMR spectroscopy and microscopic MRI. 
  • Application of magnetic resonance microscopy to tissue engineering: a polylactide model. 
  • Application of optical imaging and spectroscopy to radiation biology. 
  • Applications of magnetic resonance microscopy. 
  • Automated feedback control of body temperature for small animal studies with MR microscopy. 
  • Automated segmentation of the actively stained mouse brain using multi-spectral MR microscopy. 
  • Bmp signaling regulates proximal-distal differentiation of endoderm in mouse lung development. 
  • Calcium- and zinc-binding proteins in intracellular transport. 
  • Cell plasticity in lung injury and repair: report from an NHLBI workshop, April 19-20, 2010. 
  • Cine magnetic resonance microscopy of the rat heart using cardiorespiratory-synchronous projection reconstruction. 
  • Classification and molecular modeling of crossbridge conformations from tomograms of insect flight muscle 
  • Comparing in vivo pump-probe and multiphoton fluorescence microscopy of melanoma and pigmented lesions. 
  • Comparison of birefringent electric split-ring resonator and meanderline structures as quarter-wave plates at terahertz frequencies. 
  • Comparison of quantitative x-ray imaging and raster probing in heart cells exposed to sodium-free media 
  • Comparison of real-time PCR and microscopy for malaria parasite detection in Malawian pregnant women. 
  • Comparison of the ontogeny of protein gene product 9.5, chromogranin A and proliferating cell nuclear antigen in developing human lung 
  • Comparison of the ontogeny of protein gene product 9.5, chromogranin A and proliferating cell nuclear antigen in developing human lung. 
  • Contrast-enhanced in vivo magnetic resonance microscopy of the mouse brain enabled by noninvasive opening of the blood-brain barrier with ultrasound. 
  • Correction for specimen movement after acquisition of element-specific electron microprobe images. 
  • Correlation of DNA fragmentation and chromatin condensation in apoptotic nuclei of the Ser 6 mouse retina. 
  • Correlative light, electron, and ion microscopy on a single histologic section. 
  • Cross-phase modulation imaging. 
  • Dark-field microscopy of human feces for presumptive diagnosis of Campylobacter fetus subsp. jejuni enteritis. 
  • Design of a superconducting volume coil for magnetic resonance microscopy of the mouse brain. 
  • Design of an ultraclean computer-controlled freeze dryer for biological specimens 
  • Detection, characterization, and abundance of engineered nanoparticles in complex waters by hyperspectral imagery with enhanced Darkfield microscopy. 
  • Development of a micro mass spectrometer: Analysis of particle behavior in mems ion lens systems 
  • Diagnosis of crystal induced arthritis by dark field microscopy. 
  • Diffusion-weighted MR microscopy with fast spin-echo. 
  • Digital pathology evaluation in the multicenter Nephrotic Syndrome Study Network (NEPTUNE). 
  • Digital pathology in nephrology clinical trials, research, and pathology practice. 
  • Direct optical imaging of graphene in vitro by nonlinear femtosecond laser spectral reshaping. 
  • Dual-view acoustic-resolution photoacoustic microscopy with enhanced resolution isotropy. 
  • Dynamic contrast-enhanced MR microscopy identifies regions of therapeutic response in a preclinical model of colorectal adenocarcinoma. 
  • EM Detection of Viruses in Organ Transplant Patients 
  • Early melanoma detection: nonuniform dermoscopic features and growth. 
  • Effect of erionite on the pleural mesothelium of the Fischer 344 rat. 
  • Effect of the isoflavone genistein against galactose-induced cataracts in rats. 
  • Electron microscopy in the analysis of renal biopsies: Always the last step? 
  • Electron tomography of swollen rigor fibers 
  • Emergent properties during dorsal closure in Drosophila morphogenesis. 
  • Enhanced understanding of infectious diseases by fusing multiple datasets: a case study on malaria in the Western Brazilian Amazon region. 
  • Epithelial-mesenchymal interactions in the alteration of gene expression and morphology following lung injury. 
  • Establishing a malaria diagnostics centre of excellence in Kisumu, Kenya. 
  • FIB/SEM fabrication of nanostructures for plasmonic sensors and waveguides 
  • Fabrication of nanodot plasmonic waveguide structures using FIB milling and electron beam-induced deposition. 
  • Fast voice-coil scanning optical-resolution photoacoustic microscopy. 
  • Fiber-optic stethoscope: a cardiac monitoring and gating system for magnetic resonance microscopy. 
  • Flexible digital signal processing architecture for narrowband and spread-spectrum lock-in detection in multiphoton microscopy and time-resolved spectroscopy. 
  • Fool's gold: Why imperfect reference tests are undermining the evaluation of novel diagnostics: a reevaluation of 5 diagnostic tests for leptospirosis. 
  • Four-dimensional MR microscopy of the mouse heart using radial acquisition and liposomal gadolinium contrast agent. 
  • Four-dimensional Microscope-Integrated Optical Coherence Tomography to Visualize Suture Depth in Strabismus Surgery. 
  • Freeze-substitution and postembedding immunocytochemistry on rat taste buds: G-proteins, calcitonin gene-related peptide, and choline acetyl transferase 
  • Frontiers in electron probe microanalysis: application to cell physiology. 
  • Functional MR microscopy of the lung using hyperpolarized 3He. 
  • Functional neuroimaging of memory: implications for cognitive aging. 
  • Functional photoacoustic microscopy of diabetic vasculature. 
  • Functional photoacoustic microscopy of pH. 
  • Fungal diagnostics in pneumonia. 
  • Gastric ulceration in a patient treated with SIR-spheres. 
  • Genetic dissection of the mouse CNS using magnetic resonance microscopy. 
  • Genetic dissection of the mouse brain using high-field magnetic resonance microscopy. 
  • High numerical aperture Fourier ptychography: principle, implementation and characterization. 
  • High sensitivity and specificity of clinical microscopy in rural health facilities in western Kenya under an external quality assurance program. 
  • High-field MR microscopy using fast spin-echoes. 
  • High-resolution magnetic resonance histology of the embryonic and neonatal mouse: a 4D atlas and morphologic database. 
  • High-resolution microscopic methods for the analysis of cellular movements in Drosophila embryos. 
  • High-speed label-free functional photoacoustic microscopy of mouse brain in action. 
  • High-speed photoacoustic microscopy of mouse cortical microhemodynamics. 
  • High-throughput pooling and real-time PCR-based strategy for malaria detection. 
  • Histology by magnetic resonance microscopy. 
  • Images in cardiovascular medicine. Approaching cardiac development in three dimensions by magnetic resonance microscopy. 
  • Images in cardiovascular medicine. Approaching cardiac development in three dimensions by magnetic resonance microscopy. 
  • Imaging inflammation: direct visualization of perivascular cuffing in EAE by magnetic resonance microscopy. 
  • Imaging of intrinsic optical signals in primate cortex during epileptiform activity. 
  • Imaging techniques for small animal models of pulmonary disease: MR microscopy. 
  • Immediate alterations in intestinal oxygen saturation and blood flow after massive small bowel resection as measured by photoacoustic microscopy. 
  • Immune reconstitution syndrome in a patient with disseminated histoplasmosis and steroid taper: maintaining the perfect balance. 
  • Immunogenic cancer cell death selectively induced by near infrared photoimmunotherapy initiates host tumor immunity. 
  • Impact of Microscope-Integrated OCT on Ophthalmology Resident Performance of Anterior Segment Surgical Maneuvers in Model Eyes. 
  • Implanted coil MR microscopy of renal pathology. 
  • Improved preparation of chick embryonic samples for magnetic resonance microscopy. 
  • Improved techniques for staining and enumerating focus formation in viral infectivity assays. 
  • Improving single molecule force spectroscopy through automated real-time data collection and quantification of experimental conditions. 
  • In vivo diffusion-weighted magnetic resonance microscopy of rat spinal cord: effect of ischemia and intrathecal hyperbaric 5% lidocaine. 
  • Integration of a spectral domain optical coherence tomography system into a surgical microscope for intraoperative imaging. 
  • Interferon-gamma reduces melanosomal antigen expression and recognition of melanoma cells by cytotoxic T cells. 
  • Intra-operative microscope-integrated swept-source optical coherence tomography guided placement of Argus II retinal prosthesis. 
  • Intravascular thrombosis in skeletal muscle microcirculation after ischemia. 
  • Intravital microscopy evaluation of angiogenesis and its effects on glucose sensor performance. 
  • Investigation of neovascularization in three-dimensional porous scaffolds in vivo by a combination of multiscale photoacoustic microscopy and optical coherence tomography. 
  • Invited Review Article: Pump-probe microscopy. 
  • LOCALIZATION OF IMMUNOGLOBULINS IN CHRONIC THYROIDITIS. 
  • Label-Free Imaging of Female Genital Tract Melanocytic Lesions With Pump-Probe Microscopy: A Promising Diagnostic Tool. 
  • Lattice light-sheet microscopy: imaging molecules to embryos at high spatiotemporal resolution. 
  • Lemons to lemonade (EM techniques for salvaging suboptimal specimens) 
  • Light and electron microscopic immunocytochemical localization of PKC delta immunoreactivity in the rat central nervous system. 
  • Long-term optical brain imaging in live adult fruit flies. 
  • Look closely: Lessons prof. Gérard T. Simon might have taught 
  • MR microscopy of lung airways with hyperpolarized 3He. 
  • MR microscopy of the rat carotid artery after balloon injury by using an implanted imaging coil. 
  • MR microscopy of the rat lung using projection reconstruction. 
  • Magnetic resonance microscopy and histopathology: comparative approach of bromobenzene-induced hepatotoxicity in the rat. 
  • Magnetic resonance microscopy defines ethanol-induced brain abnormalities in prenatal mice: effects of acute insult on gestational day 7. 
  • Magnetic resonance microscopy in basic studies of brain structure and function. 
  • Magnetic resonance microscopy of embryos. 
  • Magnetic resonance microscopy of morphological alterations in mouse trabecular bone structure under conditions of simulated microgravity. 
  • Magnetic resonance microscopy of the rat carotid artery at 300 megahertz. 
  • Magnetic resonance microscopy of toxic renal injury induced by bromoethylamine in rats. 
  • Magnetic resonance microscopy--a new tool for the toxicologic pathologist. 
  • Magnetic resonance microscopy-based analyses of the brains of normal and ethanol-exposed fetal mice. 
  • Magnetic resonance microscopy. 
  • Magnetic resonance microscopy. 
  • Magnetic resonance microscopy: in vivo sectioning of a developing insect. 
  • Malaria surveillance in the Democratic Republic of the Congo: comparison of microscopy, PCR, and rapid diagnostic test. 
  • Maximizing contrast to noise with inductively coupled implanted coils. 
  • Measurement of boundaries using a digitizer tablet 
  • Measurement of interbilayer adhesion energies. 
  • Measuring the progression of foreign-body reaction to silicone implants using in vivo MR microscopy. 
  • Mechanical measurement of red cell membrane thickness. 
  • Microchemical anatomy and pathogenesis of the protozoan parasite Leishmania 
  • Microscope-Integrated Optical Coherence Tomography Angiography in the Operating Room in Young Children With Retinal Vascular Disease. 
  • Minimal Impact by Antenatal Subpatent Plasmodium falciparum Infections on Delivery Outcomes in Malawian Women: A Cohort Study. 
  • Misidentification of Neosartorya pseudofischeri as Aspergillus fumigatus in a lung transplant patient. 
  • Modeling extensions of fourier ptychographic microscopy 
  • Modulation of podocyte phenotype in collapsing glomerulopathies. 
  • Molecular imaging and quantitative measurement of epidermal growth factor receptor expression in live cancer cells using immunolabeled gold nanoparticles. 
  • Molecular imaging of epidermal growth factor receptor in live cells with refractive index sensitivity using dark-field microspectroscopy and immunotargeted nanoparticles. 
  • Mononuclear phagocyte accumulation in visceral tissue in HIV encephalitis: evidence for increased monocyte/macrophage trafficking and altered differentiation. 
  • Morphologic phenotyping with MR microscopy: the visible mouse. 
  • Morphological evidence for adhesive role of thin-symmetric junctions in undulating membranes of lens nuclear fiber cells 
  • Morphology in the Digital Age: Integrating High-Resolution Description of Structural Alterations With Phenotypes and Genotypes. 
  • Morphology of the small-animal lung using magnetic resonance microscopy. 
  • Multi-resolution 3D visualization of the early stages of cellular uptake of peptide-coated nanoparticles. 
  • Multicontrast nonlinear optical microscopy with a compact and rapid pulse shaper. 
  • Nanosecond-exposure electron microscopy of laser-induced phase transformations 
  • Natural variation in CDC28 underlies morphological phenotypes in an environmental yeast isolate. 
  • Neuroimaging of memory. Introduction. 
  • Non invasive high resolution in vivo imaging of alpha-naphthylisothiocyanate (ANIT) induced hepatobiliary toxicity in STII medaka. 
  • Nonlinear absorption microscopy. 
  • Novel quantitative method to evaluate globotriaosylceramide inclusions in renal peritubular capillaries by virtual microscopy in patients with fabry disease. 
  • Nuclear repulsion enables division autonomy in a single cytoplasm. 
  • On some iterative concepts for image restoration 
  • Optical clearing-aided photoacoustic microscopy with enhanced resolution and imaging depth. 
  • Optical near-field mapping of plasmonic nanoprisms. 
  • Oversampled triangulation of AWARE-10 monocentric ball lens using an auto-stigmatic microscope. 
  • Performance of a high-temperature superconducting probe for in vivo microscopy at 2.0 T. 
  • Photoacoustic microscopy of tyrosinase reporter gene in vivo. 
  • Photoacoustic microscopy: superdepth, superresolution, and superb contrast. 
  • Phototaxis by the dinoflagellate Gymnodinium splendens Lebour. 
  • Photothermal optical coherence tomography of epidermal growth factor receptor in live cells using immunotargeted gold nanospheres. 
  • Pilot assessment of the sensitivity of the malaria thin film. 
  • Plasmacytic or lymphoplasmacytic infiltrate in lymph nodes: Diagnostic approach and differential considerations. 
  • Polymerase chain reaction analysis of distal vaginal specimens: a less invasive strategy for detection of Trichomonas vaginalis. 
  • Preclinical evaluation and intraoperative human retinal imaging with a high-resolution microscope-integrated spectral domain optical coherence tomography device. 
  • Prevalence and density-related concordance of three diagnostic tests for malaria in a region of Tanzania with hypoendemic malaria. 
  • Prevalence and distribution of human Plasmodium infection in Pakistan. 
  • Problems and Pitfalls in Diagnostic Electron Microscopy 
  • Proceedings microscopy and microanalysis 2004: Foreword 
  • Protein-resistant polymer coatings on silicon oxide by surface-initiated atom transfer radical polymerization. 
  • Pulsating tandem microbubble for localized and directional single-cell membrane poration. 
  • Pump-probe imaging of historical pigments used in paintings. 
  • Pump-probe nonlinear phase dispersion spectroscopy. 
  • Quantifying melanin spatial distribution using pump-probe microscopy and a 2-D morphological autocorrelation transformation for melanoma diagnosis. 
  • Quantitative EPXMA imaging of rapidly frozen kidney proximal tubule primary cultures 
  • Quantitative phase microscopy spatial signatures of cancer cells. 
  • Quantitative phase microscopy with off-axis optical coherence tomography. 
  • Quick-freezing of cultured cardiac cells in situ with special attention to the mitochondrial ultrastructure. 
  • Rapid Diagnostic Test Performance Assessed Using Latent Class Analysis for the Diagnosis of Plasmodium falciparum Placental Malaria. 
  • Rapid ultrastructural changes in Leishmania donovani amastigotes in response to hypo-osmotic stress 
  • Real-time quantitative elemental analysis and mapping: microchemical imaging in cell physiology. 
  • Registered (1)H and (3)He magnetic resonance microscopy of the lung. 
  • Relaxation measurements at 300 MHz using MR microscopy. 
  • Reproductive cytotoxicity is predicted by magnetic resonance microscopy and confirmed by ubiquitin-proteasome immunohistochemistry in a theophylline-induced model of rat testicular and epididymal toxicity. 
  • Retinal phototoxicity from the operating microscope. The role of inspired oxygen. 
  • Retinal phototoxicity from the operating microscope: a protective effect by the fovea. 
  • Retinoids and retinoic acid receptors regulate growth arrest and apoptosis in human mammary epithelial cells and modulate expression of CBP/p300. 
  • Review of methods used to study oxygen transport at the microcirculatory level. 
  • Role of electron microscopy in monitoring for potential smallpox cases and other rash illnesses 
  • Selective contrast in electron microscopy of crystalline cytochrome oxidase 
  • Sensitivity and resolution in 3D NMR microscopy of the lung with hyperpolarized noble gases. 
  • Simultaneous two-wavelength transmission quantitative phase microscopy with a color camera. 
  • Single-target molecule detection with nonbleaching multicolor optical immunolabels. 
  • Small animal imaging with magnetic resonance microscopy. 
  • Sources of variability in determining malaria parasite density by microscopy. 
  • Spectral imaging facilitates visualization and measurements of unstable and abnormal microvascular oxygen transport in tumors. 
  • Spinal cord neural anatomy in rats examined by in vivo magnetic resonance microscopy. 
  • Spindle cell sarcoma of the vulva with myofibroblastic differentiation. 
  • Static and Dynamic Microscopy of the Chemical Stability and Aggregation State of Silver Nanowires in Components of Murine Pulmonary Surfactant. 
  • Structure and phase behavior of lipid suspensions containing phospholipids with covalently attached poly(ethylene glycol). 
  • Structured illumination diffraction phase microscopy for broadband, subdiffraction resolution, quantitative phase imaging. 
  • Studies on bromobenzene-induced hepatotoxicity using in vivo MR microscopy with surgically implanted RF coils. 
  • Surgilube as a replacement for oil during dermoscopic examination. 
  • Surveillance of bioterrorism agents: Considerations for EM laboratories 
  • Systematics of the genus Chaetosphaeria and its allied genera: morphological and phylogenetic diversity in north temperate and neotropical taxa. 
  • T1 rho relaxation and its application to MR histology. 
  • Test of the Epstein-Plesset model for gas microparticle dissolution in aqueous media: effect of surface tension and gas undersaturation in solution. 
  • The Application of Digital Pathology to Improve Accuracy in Glomerular Enumeration in Renal Biopsies. 
  • The electron microscopy of chemosensory hairs. 
  • The morphologic characteristics of tumor blood vessels as a marker of tumor progression in primary human uveal melanoma: a matched case-control study. 
  • The place of microsurgery in hand surgery. 
  • The use of fluorescein sodium in the biopsy and gross-total resection of a tectal plate glioma. 
  • Three-dimensional imaging of xenograft tumors using optical computed and emission tomography. 
  • Three-dimensional magnetic resonance microscopy of the developing chick embryo. 
  • Time-resolved imaging refractometry of microbicidal films using quantitative phase microscopy. 
  • Tracking brain volume changes in C57BL/6J and ApoE-deficient mice in a model of neurodegeneration: a 5-week longitudinal micro-MRI study. 
  • Transformation optics 
  • Transforming growth factor-beta signaling in cancer. 
  • Tutorial on photoacoustic tomography. 
  • Two and three-dimensional gene transfer from enzymatically degradable hydrogel scaffolds. 
  • Ultrasound-heated photoacoustic flowmetry. 
  • Ultrastructural Analysis of Vesicular Transport in Electrotransfection. 
  • Unprocessed real-time imaging of vitreoretinal surgical maneuvers using a microscope-integrated spectral-domain optical coherence tomography system. 
  • Up-regulation of hypoxia-inducible factor 1 alpha and hemodynamic responses following massive small bowel resection. 
  • Using a multigene phylogenetic analysis to assess generic delineation and character evolution in Verrucariaceae (Verrucariales, Ascomycota). 
  • VA/Q abnormalities during gram negative sepsis. 
  • VISUALIZATION FROM INTRAOPERATIVE SWEPT-SOURCE MICROSCOPE-INTEGRATED OPTICAL COHERENCE TOMOGRAPHY IN VITRECTOMY FOR COMPLICATIONS OF PROLIFERATIVE DIABETIC RETINOPATHY. 
  • Visualization of cortical, subcortical and deep brain neural circuit dynamics during naturalistic mammalian behavior with head-mounted microscopes and chronically implanted lenses. 
  • Visualization of real-time intraoperative maneuvers with a microscope-mounted spectral domain optical coherence tomography system. 
  • Vital gene and organelle targeting with TiO2-oligonucleotide nanocomposites in Leishmania donovani 
  • Vital imaging of glomeruli in the mouse olfactory bulb. 
  • Volume and osmotic properties of human neutrophils. 
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  Keywords of People

  • Badea, Cristian Tudorel, Professor in Radiology, Biomedical Engineering
  • Driehuys, Bastiaan, Professor of Radiology, Physics
  • Farsiu, Sina, Paul Ruffin Scarborough Associate Professor of Engineering, Electrical and Computer Engineering
  • Fischer, Martin, Associate Research Professor in the Department of Chemistry, Chemistry
  • Gong, Yiyang, Assistant Professor in the Department of Biomedical Engineering, Duke Science & Society
  • Hogan, Brigid L. M., George Barth Geller Professor, Cell Biology
  • Horstmeyer, Roarke W., Assistant Professor of Biomedical Engineering, Electrical and Computer Engineering
  • Johnson, G. Allan, Charles E. Putman University Professor of Radiology, Physics
  • MacFall, James R., Adjunct Professor in the Department of Radiology, Radiology
  • Mruthyunjaya, Prithvi, Adjunct Associate Professor in the Department of Ophthalmology, Ophthalmology, Vitreoretinal Diseases & Surgery
  • O'Meara, Wendy P, Associate Professor in Medicine, Medicine, Infectious Diseases
  • Palmer, Gregory M., Associate Professor of Radiation Oncology, Radiation Oncology
  • Schmehl, Meredith, Student, Neurobiology
  • Toth, Cynthia Ann, Joseph A.C. Wadsworth Professor of Ophthalmology, Ophthalmology, Vitreoretinal Diseases & Surgery
  • Warner, David Samuel, Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology
  • Wax, Adam P., Professor of Biomedical Engineering, Biomedical Engineering
  • Zhong, Pei, Professor in the Department of Mechanical Enginnering and Materials Science, Mechanical Engineering and Materials Science