Microscopy, Fluorescence

• 

  Subject Areas on Research

  • A CDC6 protein-binding peptide selected using a bacterial two-hybrid-like system is a cell cycle inhibitor. 
  • A Mep2-dependent transcriptional profile links permease function to gene expression during pseudohyphal growth in Saccharomyces cerevisiae. 
  • A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF. 
  • A cis-acting sequence homologous to the yeast filamentation and invasion response element regulates expression of a pectinase gene from the bean pathogen Colletotrichum lindemuthianum. 
  • A compact CMOS biochip immunosensor towards the detection of a single bacteria. 
  • A comprehensive method for optical-emission computed tomography. 
  • A developmental mutation (npfL1) resulting in cell death in Physarum polycephalum. 
  • A low-cost high-efficiency fiber-optic coupler for recording action potentials within the myocardial wall. 
  • A paclitaxel-loaded recombinant polypeptide nanoparticle outperforms Abraxane in multiple murine cancer models. 
  • A pressure-mediated nonviral method for efficient arterial gene and oligonucleotide transfer. 
  • A protocol for imaging alternative splicing regulation in vivo using fluorescence reporters in transgenic mice. 
  • A receptor for activated C3 in the human renal glomerular capillary wall. 
  • A role for Rac3 GTPase in the regulation of autophagy. 
  • A three-dimensional ParF meshwork assembles through the nucleoid to mediate plasmid segregation. 
  • ADF/cofilin promotes invadopodial membrane recycling during cell invasion in vivo. 
  • APC-mediated downregulation of beta-catenin activity involves nuclear sequestration and nuclear export. 
  • ATM functions at the peroxisome to induce pexophagy in response to ROS. 
  • Abl-interactor-1 (Abi1) has a role in cardiovascular and placental development and is a binding partner of the alpha4 integrin. 
  • Acceleration of functional reentry by rapid pacing in anisotropic cardiac monolayers: formation of multi-wave functional reentries. 
  • Age-dependent impairment of glucose tolerance in the 3xTg-AD mouse model of Alzheimer's disease. 
  • Agonist-induced internalization of the substance P (NK1) receptor expressed in epithelial cells. 
  • Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. 
  • Alpha-2 adrenergic receptors stimulate actin organization in developing fetal rat cardiac myocytes. 
  • Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. 
  • An engineered Saccharomyces cerevisiae strain binds the broadly neutralizing human immunodeficiency virus type 1 antibody 2G12 and elicits mannose-specific gp120-binding antibodies. 
  • An equilibrium model of endothelial cell adhesion via integrin-dependent and integrin-independent ligands. 
  • An interdomain interaction of the androgen receptor is required for its aggregation and toxicity in spinal and bulbar muscular atrophy. 
  • Analysis of allosteric signal transduction mechanisms in an engineered fluorescent maltose biosensor. 
  • Analyzing mRNA localization to the endoplasmic reticulum via cell fractionation. 
  • Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments. 
  • Anti-GM2 monoclonal antibodies induce necrosis in GM2-rich cultures of a human glioma cell line. 
  • Antiangiogenic treatment with three thrombospondin-1 type 1 repeats versus gemcitabine in an orthotopic human pancreatic cancer model. 
  • Apolipoprotein E-deficient mice created by systemic administration of antisense oligodeoxynucleotides: a new model for lipoprotein metabolism studies. 
  • Apoptosis is the mode of cell death caused by carcinogenic chromium. 
  • Application of total internal reflection fluorescence microscopy to study cell adhesion to biomaterials. 
  • Aptamer-mediated delivery of chemotherapy to pancreatic cancer cells. 
  • Aquaglyceroporin AQP9: solute permeation and metabolic control of expression in liver. 
  • Arc/Arg3.1 translation is controlled by convergent N-methyl-D-aspartate and Gs-coupled receptor signaling pathways. 
  • Assessment of the CFTR and ENaC association. 
  • Astrocyte cytolysis by MHC class II-specific mouse T cell clones. 
  • Atomic force and total internal reflection fluorescence microscopy for the study of force transmission in endothelial cells. 
  • BRCA1 is required for common-fragile-site stability via its G2/M checkpoint function. 
  • Bacterial biofilm in acute lesions of hidradenitis suppurativa. 
  • Binding of tissue-type plasminogen activator to the glucose-regulated protein 78 (GRP78) modulates plasminogen activation and promotes human neuroblastoma cell proliferation in vitro. 
  • Biocatalytic microcontact printing. 
  • Bioluminescence resonance energy transfer identify scaffold protein CNK1 interactions in intact cells. 
  • Bioluminescent virion shells: new tools for quantitation of AAV vector dynamics in cells and live animals. 
  • Borg proteins control septin organization and are negatively regulated by Cdc42. 
  • CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1. 
  • Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. 
  • Calcium-sensing receptor regulates stomatal closure through hydrogen peroxide and nitric oxide in response to extracellular calcium in Arabidopsis. 
  • Calmodulin overexpression causes Ca(2+)-dependent apoptosis of pancreatic beta cells, which can be prevented by inhibition of nitric oxide synthase. 
  • Carbon monoxide, skeletal muscle oxidative stress, and mitochondrial biogenesis in humans. 
  • Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia. 
  • Caspase 3 promotes surviving melanoma tumor cell growth after cytotoxic therapy. 
  • Caspase-8-mediated apoptosis in human RPE cells. 
  • Cell cycle-dependent expression of thyroid hormone receptor-beta is a mechanism for variable hormone sensitivity. 
  • Cell-cell interactions regulate skeleton formation in the sea urchin embryo. 
  • Cellular events during sexual development from amoeba to plasmodium in the slime mould Physarum polycephalum. 
  • Cellular senescence in the glaucomatous outflow pathway. 
  • Centromeric chromatin exhibits a histone modification pattern that is distinct from both euchromatin and heterochromatin. 
  • Changes in the distribution of GAP-43 during the development of neuronal polarity. 
  • Characterization of Langerin-expressing dendritic cell subsets in the normal cornea. 
  • Characterization of the absence of an unique DNA-binding protein in senescent but not in their young growing and nongrowing counterparts provides the means to mark the final stage of the cellular aging process. 
  • Cholinergic augmentation of insulin release requires ankyrin-B. 
  • Circulating tumor cells in melanoma patients. 
  • Clathrin phosphorylation is required for actin recruitment at sites of bacterial adhesion and internalization. 
  • Cloned endothelium derived from autoimmune vascular disease retain structural and functional characteristics of normal endothelial cells. 
  • Coiled-coil targeting of myocilin to intracellular membranes. 
  • Comparison of benefits on myocardial performance of cellular cardiomyoplasty with skeletal myoblasts and fibroblasts. 
  • Concerted use of immunologic and ultrastructural analyses in diagnostic medicine: immunoelectron microscopy and correlative microscopy. 
  • Confocal imaging of intracellular chloride in living brain slices: measurement of GABAA receptor activity. 
  • Conformational dynamics of amyloid beta-protein assembly probed using intrinsic fluorescence. 
  • Constitutive arrestin-mediated desensitization of a human vasopressin receptor mutant associated with nephrogenic diabetes insipidus. 
  • Constitutive protease-activated receptor-2-mediated migration of MDA MB-231 breast cancer cells requires both beta-arrestin-1 and -2. 
  • Constitutively active alpha-1b adrenergic receptor mutants display different phosphorylation and internalization features. 
  • Contribution of IL-13 to early exocrinopathy in Id3-/- mice. 
  • Contribution of aerobic photoheterotrophic bacteria to the carbon cycle in the ocean. 
  • Control of RhoA methylation by carboxylesterase I. 
  • Copper-stimulated endocytosis and degradation of the human copper transporter, hCtr1. 
  • Cti6 is an Rpd3-Sin3 histone deacetylase-associated protein required for growth under iron-limiting conditions in Saccharomyces cerevisiae. 
  • Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domain. 
  • Cultured human trabecular meshwork cells express functional alpha 2A adrenergic receptors. 
  • Cutaneous manifestations of serum sickness in patients receiving antithymocyte globulin. 
  • Cyclic mechanical stress and trabecular meshwork cell contractility. 
  • Definition of distinct compartments in polarized Madin-Darby canine kidney (MDCK) cells for membrane-volume sorting, polarized sorting and apical recycling. 
  • Deformable Graph Model for Tracking Epithelial Cell Sheets in Fluorescence Microscopy. 
  • Dependence of corneal stem/progenitor cells on ocular surface innervation. 
  • Desert Hedgehog/Patched 1 signaling specifies fetal Leydig cell fate in testis organogenesis. 
  • Destabilization of the VCP-Ufd1-Npl4 complex is associated with decreased levels of ERAD substrates. 
  • Developing Repair Materials for Stress Urinary Incontinence to Withstand Dynamic Distension. 
  • Developing nodes of Ranvier are defined by ankyrin-G clustering and are independent of paranodal axoglial adhesion. 
  • Development of a fluorescent microsphere technique for rapid histological determination of cerebral blood flow. 
  • Development of a neutral embedding resin for optical imaging of fluorescently labeled biological tissue. 
  • Development of an advanced hyperspectral imaging (HSI) system with applications for cancer detection. 
  • Differential effects of inhibiting chitin and 1,3-{beta}-D-glucan synthesis in ras and calcineurin mutants of Aspergillus fumigatus. 
  • Differential effects of prostate cancer therapeutics on neuroendocrine transdifferentiation. 
  • Differential specificities and simultaneous occupancy of human MutSalpha nucleotide binding sites. 
  • Differential staining of actin in metaphase spindles with 7-nitrobenz-2-oxa-1,3-diazole-phallacidin and fluorescent DNase: is actin involved in chromosomal movement? 
  • Diploid strains of the pathogenic basidiomycete Cryptococcus neoformans are thermally dimorphic. 
  • Direct In Vivo Manipulation and Imaging of Calcium Transients in Neutrophils Identify a Critical Role for Leading-Edge Calcium Flux. 
  • Direct measurement of hypoxia in a xenograft multiple myeloma model by optical-resolution photoacoustic microscopy. 
  • Disappearance of the telomere dysfunction-induced stress response in fully senescent cells. 
  • Distinct Roles of Sensory Neurons in Mediating Pathogen Avoidance and Neuropeptide-Dependent Immune Regulation. 
  • Distinct roles for β-arrestin2 and arrestin-domain-containing proteins in β2 adrenergic receptor trafficking. 
  • Diversity, topographic differentiation, and positional memory in human fibroblasts. 
  • Domain 3 of hepatitis C virus core protein is sufficient for intracellular lipid accumulation. 
  • Double-labeling of saphenous nerve neuron pools: a model for determining the accuracy of axon regeneration at the single neuron level. 
  • Doxorubicin-conjugated chimeric polypeptide nanoparticles that respond to mild hyperthermia. 
  • Drd1a-tdTomato BAC transgenic mice for simultaneous visualization of medium spiny neurons in the direct and indirect pathways of the basal ganglia. 
  • Drosophila APC2 and Armadillo participate in tethering mitotic spindles to cortical actin. 
  • Drug targeting using thermally responsive polymers and local hyperthermia. 
  • Dual-energy computed tomography imaging of atherosclerotic plaques in a mouse model using a liposomal-iodine nanoparticle contrast agent. 
  • Dynamic movements of organelles containing Niemann-Pick C1 protein: NPC1 involvement in late endocytic events. 
  • Dynamics of Delta/Notch signaling on endomesoderm segregation in the sea urchin embryo. 
  • EZH2 regulates the transcription of estrogen-responsive genes through association with REA, an estrogen receptor corepressor. 
  • Early human T cell development: analysis of the human thymus at the time of initial entry of hematopoietic stem cells into the fetal thymic microenvironment. 
  • Early photon tomography allows fluorescence detection of lung carcinomas and disease progression in mice in vivo. 
  • Early wound healing exhibits cytokine surge without evidence of hypoxia. 
  • Effect of interferon-gamma and human alpha 2-macroglobulin on peritoneal macrophage morphology and Ia antigen expression. 
  • Effect of receptor-ligand affinity on the strength of endothelial cell adhesion. 
  • Effects of sampling strategy on image quality in noncontact panoramic fluorescence diffuse optical tomography for small animal imaging. 
  • Emergent properties during dorsal closure in Drosophila morphogenesis. 
  • Endothelial nitric oxide synthase-related mechanotransduction changes in aged porcine angular aqueous plexus cells. 
  • Enhanced chondrogenic differentiation of embryonic stem cells by coculture with hepatic cells. 
  • Enhanced green fluorescent protein as a marker for localizing murine cytomegalovirus in acute and latent infection. 
  • Enhancement of persistent sodium current by internal fluorescence in isolated hippocampal neurons. 
  • Establishment of three-dimensional cultures of human pancreatic duct epithelial cells. 
  • Esterified and unesterified cholesterol in drusen and basal deposits of eyes with age-related maculopathy. 
  • Experimental validation of an inverse fluorescence Monte Carlo model to extract concentrations of metabolically relevant fluorophores from turbid phantoms and a murine tumor model. 
  • Explant culture of adult zebrafish hearts for epicardial regeneration studies. 
  • Expression of a mitochondrial progesterone receptor in human spermatozoa correlates with a progestin-dependent increase in mitochondrial membrane potential. 
  • Expression of cell cycle related proteins--proliferating cell nuclear antigen (PCNA) and statin--during adaptation and de-adaptation of EUE cells to a hypertonic medium. 
  • Expression of dominant negative Rho-binding domain of Rho-kinase in organ cultured human eye anterior segments increases aqueous humor outflow. 
  • Expression of human protein phosphatase-1 in Saccharomyces cerevisiae highlights the role of phosphatase isoforms in regulating eukaryotic functions. 
  • Expression of the Salmonella spp. virulence factor SifA in yeast alters Rho1 activity on peroxisomes. 
  • Feedback control of Swe1p degradation in the yeast morphogenesis checkpoint. 
  • Flow cytometric analysis of DNA content in budding yeast. 
  • Flow velocity in the superficial lymphatic network of the mouse tail. 
  • Fluorescence imaging of changes in intracellular chloride in living brain slices. 
  • Fluorescence staining of the actin cytoskeleton in living cells with 7-nitrobenz-2-oxa-1,3-diazole-phallacidin. 
  • Fluorescence-based isolation of bacterial genes expressed within host cells. 
  • Fluorescence-based measurement of cystine uptake through xCT shows requirement for ROS detoxification in activated lymphocytes. 
  • Fluorescent low density lipoprotein for observation of dynamics of individual receptor complexes on cultured human fibroblasts. 
  • Folate-targeted nanoparticle delivery of chemo- and radiotherapeutics for the treatment of ovarian cancer peritoneal metastasis. 
  • Formation of Tap/NXT1 heterodimers activates Tap-dependent nuclear mRNA export by enhancing recruitment to nuclear pore complexes. 
  • FtsZ from divergent foreign bacteria can function for cell division in Escherichia coli. 
  • Functional imaging in bulk tissue specimens using optical emission tomography: fluorescence preservation during optical clearing. 
  • G protein-coupled receptor desensitization as a measure of signaling: modeling of arrestin recruitment to activated CCK-B receptors. 
  • G-protein-coupled receptor (GPCR) kinase phosphorylation and beta-arrestin recruitment regulate the constitutive signaling activity of the human cytomegalovirus US28 GPCR. 
  • Galectin-1 drives lymphoma CD20 immunotherapy resistance: validation of a preclinical system to identify resistance mechanisms. 
  • Gelatin-embedded cell-polymer constructs for histological cryosectioning. 
  • Gene therapy rescues cilia defects and restores olfactory function in a mammalian ciliopathy model. 
  • Genome-wide significant risk associations for mucinous ovarian carcinoma. 
  • Glutamate decreases mitochondrial size and movement in primary forebrain neurons. 
  • Graft-extrinsic cells predominate in vein graft arterialization. 
  • Green fluorescent protein as a tag for molecular motor proteins. 
  • Growth factor erv1-like modulates Drp1 to preserve mitochondrial dynamics and function in mouse embryonic stem cells. 
  • Growth factor induced activation of Rho and Rac GTPases and actin cytoskeletal reorganization in human lens epithelial cells. 
  • Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. 
  • Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. 
  • HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy. 
  • Hereditary alterations in the immune response: coexistence of "agammaglobulinemia", acquired hypogammaglobulinemia and selective immunoglobulin deficiency in a sibship. 
  • Herpesviruses carrying a Brainbow cassette reveal replication and expression of limited numbers of incoming genomes. 
  • High-resolution high-speed panoramic cardiac imaging system. 
  • Histopathologic features of adult-onset foveomacular pigment epithelial dystrophy. 
  • How the kinetochore couples microtubule force and centromere stretch to move chromosomes. 
  • How vinculin regulates force transmission. 
  • Hsp90 is an essential regulator of EphA2 receptor stability and signaling: implications for cancer cell migration and metastasis. 
  • Human lung innate immune response to Bacillus anthracis spore infection. 
  • Human lymphocyte surface immunoglobulin capping. Normal characteristics and anomalous behavior of chronic lymphocytic leukemic lymphocytes. 
  • Human mesenchymal stem cell and epithelial hepatic carcinoma cell lines in admixture: concurrent stimulation of cancer-associated fibroblasts and epithelial-to-mesenchymal transition markers. 
  • Human retroviral gag- and gag-pol-like proteins interact with the transforming growth factor-beta receptor activin receptor-like kinase 1. 
  • Humoral immunostimulation. IV. Role of complement. 
  • Humoral responses to pig-to-baboon cardiac transplantation: implications for the pathogenesis and treatment of acute vascular rejection and for accommodation. 
  • Hyaluronic acid and fibrin hydrogels with concentrated DNA/PEI polyplexes for local gene delivery. 
  • Hyperspectral imaging of hemoglobin saturation in tumor microvasculature and tumor hypoxia development. 
  • ICAM-1 expression in autoimmune encephalitis visualized using magnetic resonance imaging. 
  • Identification of a vacuole-associated metalloreductase and its role in Ctr2-mediated intracellular copper mobilization. 
  • Identification of centromeric antigens in dicentric Robertsonian translocations: CENP-C and CENP-E are necessary components of functional centromeres. 
  • Identification of methionine-rich clusters that regulate copper-stimulated endocytosis of the human Ctr1 copper transporter. 
  • Identification of the TBX5 transactivating domain and the nuclear localization signal. 
  • IgA and IgG antineutrophil cytoplasmic antibody engagement of Fc receptor genetic variants influences granulomatosis with polyangiitis. 
  • Image segmentation and dynamic lineage analysis in single-cell fluorescence microscopy. 
  • Imaging Polarization in Budding Yeast. 
  • Imaging alternative splicing in living cells. 
  • Imaging of cell/substrate contacts on polymers by total internal reflection fluorescence microscopy. 
  • Imaging spatiotemporal dynamics of neuronal signaling using fluorescence resonance energy transfer and fluorescence lifetime imaging microscopy. 
  • Imaging the behavior of molecules in biological systems: breaking the 3D speed barrier with 3D multi-resolution microscopy. 
  • Immunohistochemistry of the canine vomeronasal organ. 
  • Immunotargeted nanoshells for integrated cancer imaging and therapy. 
  • Implementation of an NSOM system for fluorescence microscopy. 
  • Improving sensitivity and specificity of capturing and detecting targeted cancer cells with anti-biofouling polymer coated magnetic iron oxide nanoparticles. 
  • In vitro characterization of vascular endothelial growth factor and dexamethasone releasing hydrogels for implantable probe coatings. 
  • In vivo analysis of white adipose tissue in zebrafish. 
  • In vivo characterization of Escherichia coli ftsZ mutants: effects on Z-ring structure and function. 
  • In vivo dynamics of clathrin and its adaptor-dependent recruitment to the actin-based endocytic machinery in yeast. 
  • In vivo fluorescence imaging: a personal perspective. 
  • In vivo gene delivery and visualization of corneal stromal cells using an adenoviral vector and keratocyte-specific promoter. 
  • In vivo protein expression and immune responses generated by DNA vaccines expressing mycobacterial antigens fused with a reporter protein. 
  • In vivo tumor targeting by a NGR-decorated micelle of a recombinant diblock copolypeptide. 
  • Increased microvascular permeability contributes to preferential accumulation of Stealth liposomes in tumor tissue. 
  • Induction of apoptosis in tumor-associated endothelial cells and therapy of orthotopic human pancreatic carcinoma in nude mice. 
  • Induction of apoptotic cell death by particulate lead chromate: differential effects of vitamins C and E on genotoxicity and survival. 
  • Inhibition of integrative repair of the meniscus following acute exposure to interleukin-1 in vitro. 
  • Initial amplification of duck hepatitis B virus covalently closed circular DNA after in vitro infection of embryonic duck hepatocytes is increased by cell cycle progression. 
  • Initial stages of tumor cell-induced angiogenesis: evaluation via skin window chambers in rodent models. 
  • Inositol 1,4,5-trisphosphate receptor localization and stability in neonatal cardiomyocytes requires interaction with ankyrin-B. 
  • Integrating valve-inspired design features into poly(ethylene glycol) hydrogel scaffolds for heart valve tissue engineering. 
  • Integrin-linked kinase: a possible role in scar contracture. 
  • Interaction between the T4 helicase loading protein (gp59) and the DNA polymerase (gp43): unlocking of the gp59-gp43-DNA complex to initiate assembly of a fully functional replisome. 
  • Interaction of Cryptococcus neoformans Rim101 and protein kinase A regulates capsule. 
  • Interaction of dihydrofolate reductase with methotrexate: ensemble and single-molecule kinetics. 
  • Interferon increases the abundance of submembranous microfilaments in HeLa-S3 cells in suspension culture. 
  • Intermediate filament associated proteins. 
  • Internalization of carcinogenic lead chromate particles by cultured normal human lung epithelial cells: formation of intracellular lead-inclusion bodies and induction of apoptosis. 
  • Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation. 
  • Intracellular third loop domain of angiotensin II type-2 receptor. Role in mediating signal transduction and cellular function. 
  • Intravital fluorescence facilitates measurement of multiple physiologic functions and gene expression in tumors of live animals. 
  • Involvement of a Rac1-Dependent Macropinocytosis Pathway in Plasmid DNA Delivery by Electrotransfection. 
  • Involvement of cellular caveolae in bacterial entry into mast cells. 
  • Isoflurane-induced neuronal degeneration: an evaluation in organotypic hippocampal slice cultures. 
  • Isolation of embryonic chick motoneurons and their survival in vitro. 
  • Kidney lesions in Rocky Mountain spotted fever: a light-, immunofluorescence-, and electron-microscopic study. 
  • LKB1 reduces ROS-mediated cell damage via activation of p38. 
  • LOCALIZATION OF IMMUNOGLOBULINS IN CHRONIC THYROIDITIS. 
  • Lectin staining of cultured CNS microglia. 
  • Localization and activity of the calcineurin catalytic and regulatory subunit complex at the septum is essential for hyphal elongation and proper septation in Aspergillus fumigatus. 
  • Localization of a baculovirus-induced chitinase in the insect cell endoplasmic reticulum. 
  • Localization of substance P NK-1 receptors in rat tongue. 
  • Locus-specific variation in phosphorylation state of RNA polymerase II in vivo: correlations with gene activity and transcript processing. 
  • Longitudinal optical imaging of tumor metabolism and hemodynamics. 
  • Loss of p53 sensitizes mice with a mutation in Ccm1 (KRIT1) to development of cerebral vascular malformations. 
  • MKKS/BBS6, a divergent chaperonin-like protein linked to the obesity disorder Bardet-Biedl syndrome, is a novel centrosomal component required for cytokinesis. 
  • Mapping neuronal inputs to REM sleep induction sites with carbachol-fluorescent microspheres. 
  • Measurement of chloride movement in neuronal preparations. 
  • Measurement of material extravasation in microvascular networks using fluorescence video-microscopy. 
  • Mechanism of apoptosis and determination of cellular fate in chromium(VI)-exposed populations of telomerase-immortalized human fibroblasts. 
  • Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: intravital microscopy and measurement of vascular permeability. 
  • Mechanisms of desensitization and resensitization of G protein-coupled neurokinin1 and neurokinin2 receptors. 
  • Mechanistic target of rapamycin complex 1 is critical for invariant natural killer T-cell development and effector function. 
  • Method for single illumination source combined optical coherence tomography and fluorescence imaging of fluorescently labeled ocular structures in transgenic mice. 
  • Mitigation of hypertrophic scar contraction via an elastomeric biodegradable scaffold. 
  • Mitochondrial biogenesis in the pulmonary vasculature during inhalational lung injury and fibrosis. 
  • Mobilization of dendritic cells from patients with breast cancer into peripheral blood stem cell leukapheresis samples using Flt-3-Ligand and G-CSF or GM-CSF. 
  • Mobilization of intracellular copper stores by the ctr2 vacuolar copper transporter. 
  • Modular nanotransporters: a multipurpose in vivo working platform for targeted drug delivery. 
  • Molecular and genetic approaches for the analysis of C. elegans neuronal development. 
  • Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis*. 
  • Molecular imaging and quantitative measurement of epidermal growth factor receptor expression in live cancer cells using immunolabeled gold nanoparticles. 
  • Monitoring intracellular proteins using fluorescence techniques: from protein synthesis and localization to activity. 
  • Monitoring β-secretase activity in living cells with a membrane-anchored FRET probe. 
  • Morphological and genomic characterization of Filobasidiella depauperata: a homothallic sibling species of the pathogenic cryptococcus species complex. 
  • Mouse germ cell clusters form by aggregation as well as clonal divisions. 
  • Multiplexed 3D FRET imaging in deep tissue of live embryos. 
  • Murine monoclonal anti-DNA antibodies penetrate cells, bind to nuclei, and induce glomerular proliferation and proteinuria in vivo. 
  • Mutants of the microtubule motor protein, nonclaret disjunctional, affect spindle structure and chromosome movement in meiosis and mitosis. 
  • Mutation of TBCE causes hypoparathyroidism-retardation-dysmorphism and autosomal recessive Kenny-Caffey syndrome. 
  • N-formyl peptide receptors internalize but do not recycle in the absence of arrestins. 
  • NADPH oxidase inhibition attenuates total body irradiation-induced haematopoietic genomic instability. 
  • Nanoscale neuro-integrative coatings for neural implants. 
  • Nanosensor for in vivo measurement of the carcinogen benzo[a]pyrene in a single cell. 
  • Near-infrared optical imaging of integrin alphavbeta3 in human tumor xenografts. 
  • Negative-stain electron microscopy of inside-out FtsZ rings reconstituted on artificial membrane tubules show ribbons of protofilaments. 
  • Neutrophil extracellular traps are pathogenic in primary graft dysfunction after lung transplantation. 
  • Nitric oxide-mediated intracellular growth restriction of pathogenic Rhodococcus equi can be prevented by iron. 
  • Nonlinear microscopy of eumelanin and pheomelanin with subcellular resolution. 
  • Novel delivery of oligonucleotides using a topical hydrogel tissue sealant in a murine partial nephrectomy model. 
  • Novel stress-responsive genes EMG1 and NOP14 encode conserved, interacting proteins required for 40S ribosome biogenesis. 
  • Nuclear responses to depletion of mitochondrial DNA in human cells. 
  • Nuclear spreads: I. Visualization of bipartite ribosomal RNA domains. 
  • O-glycosylation as a sorting determinant for cell surface delivery in yeast. 
  • Observations on the growth of loose bodies in joints. 
  • Opposing roles for actin in Cdc42p polarization. 
  • Optical coding of mammalian cells using semiconductor quantum dots. 
  • Optical imaging of cervical pre-cancers with structured illumination: an integrated approach. 
  • Optical imaging of intracellular chloride in living brain slices. 
  • Optical imaging of living brain slices. 
  • Optical sensor for the detection of caspase-9 activity in a single cell. 
  • Optimization of Single- and Dual-Color Immunofluorescence Protocols for Formalin-Fixed, Paraffin-Embedded Archival Tissues. 
  • Optimization of a polyglutamine aggregation inhibitor peptide (QBP1) using a thioflavin T fluorescence assay. 
  • Optimization of a widefield structured illumination microscope for non-destructive assessment and quantification of nuclear features in tumor margins of a primary mouse model of sarcoma. 
  • Optimizing gene transfer to conventional outflow cells in living mouse eyes. 
  • Optogenetic probes. 
  • Osmotic loading to determine the intrinsic material properties of guinea pig knee cartilage. 
  • Oxidant-induced cell death in retinal pigment epithelium cells mediated through the release of apoptosis-inducing factor. 
  • PI3K inhibitors block skeletogenesis but not patterning in sea urchin embryos. 
  • Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration. 
  • Pcp1p, an Spc110p-related calmodulin target at the centrosome of the fission yeast Schizosaccharomyces pombe. 
  • Pdgfr-alpha mediates testis cord organization and fetal Leydig cell development in the XY gonad. 
  • Perivascular mural cells of the mouse choroid demonstrate morphological diversity that is correlated to vasoregulatory function. 
  • Persistent genetic instability in cancer cells induced by non-DNA-damaging stress exposures. 
  • Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation. 
  • Phosphorylation of phosphatase inhibitor-2 at centrosomes during mitosis. 
  • Photothermal optical coherence tomography of epidermal growth factor receptor in live cells using immunotargeted gold nanospheres. 
  • Plasminogen structural domains exhibit different functions when associated with cell surface GRP78 or the voltage-dependent anion channel. 
  • Platelets contain releasable coagulation factor IX antigen. 
  • Platelets contain releasable coagulation factor IX antigen: response. 
  • Pmp-like proteins Pls1 and Pls2 are secreted into the lumen of the Chlamydia trachomatis inclusion. 
  • Polymer hydrogels: Chaperoning vaccines. 
  • Polyploidy and Mitotic Cell Death Are Two Distinct HIV-1 Vpr-Driven Outcomes in Renal Tubule Epithelial Cells. 
  • Potassium-induced enhancement of persistent inward current in hippocampal neurons in isolation and in tissue slices. 
  • Preferential extravasation and accumulation of liposomal vincristine in tumor comparing to normal tissue enhances antitumor activity. 
  • Pressure-mediated oligonucleotide transfection of rat and human cardiovascular tissues. 
  • Preventing stem cell incorporation into choroidal neovascularization by targeting homing and attachment factors. 
  • Prochelator BHAPI protects cells against paraquat-induced damage by ROS-triggered iron chelation. 
  • Projections from the ventral cochlear nucleus to the inferior colliculus and the contralateral cochlear nucleus in guinea pigs. 
  • Proliferative glomerulonephritis in children. A correlation of varied clinical and pathologic patterns utilizing light, immunofluorescence, and electron microscopy. 
  • Properties of procoagulant platelets: defining and characterizing the subpopulation binding a functional prothrombinase. 
  • Protease degradable tethers for controlled and cell-mediated release of nanoparticles in 2- and 3-dimensions. 
  • Protein kinase C isoforms in human aortic smooth muscle cells. 
  • Protein phosphatase 5 is required for ATR-mediated checkpoint activation. 
  • Quantification of erythrocyte flow in the choroid of the albino rat. 
  • Quantification of transcription factor expression from Arabidopsis images. 
  • Quantifying synapses: an immunocytochemistry-based assay to quantify synapse number. 
  • Quantitative Segmentation of Fluorescence Microscopy Images of Heterogeneous Tissue: Application to the Detection of Residual Disease in Tumor Margins. 
  • Quantitative analysis of Pc 4 localization in mouse lymphoma (LY-R) cells via double-label confocal fluorescence microscopy. 
  • Quantitative analysis of variable-angle total internal reflection fluorescence microscopy (VA-TIRFM) of cell/substrate contacts. 
  • Quantitative laser scanning confocal autofluorescence microscopy of normal, premalignant, and malignant colonic tissues. 
  • Quantitative mass spectrometry of DENV-2 RNA-interacting proteins reveals that the DEAD-box RNA helicase DDX6 binds the DB1 and DB2 3' UTR structures. 
  • Quantitative optical microscopy and micromanipulation studies on the lipid bilayer membranes of giant unilamellar vesicles. 
  • RANK, RANKL, OPG, and M-CSF expression in stromal cells during corneal wound healing. 
  • RPGR isoforms in photoreceptor connecting cilia and the transitional zone of motile cilia. 
  • Rab11 helps maintain apical crumbs and adherens junctions in the Drosophila embryonic ectoderm. 
  • Reactivation of p53 by a Cytoskeletal Sensor to Control the Balance Between DNA Damage and Tumor Dissemination. 
  • Recapitulation of the sexual cycle of the primary fungal pathogen Cryptococcus neoformans var. gattii: implications for an outbreak on Vancouver Island, Canada. 
  • Receptor-recognized alpha 2-macroglobulin-methylamine elevates intracellular calcium, inositol phosphates and cyclic AMP in murine peritoneal macrophages. 
  • Receptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes. 
  • Reconstruction of cell population dynamics using CFSE. 
  • Regulation of E2A activities by histone acetyltransferases in B lymphocyte development. 
  • Regulation of T-cell survival and mitochondrial homeostasis by TSC1. 
  • Regulation of arrestin-3 phosphorylation by casein kinase II. 
  • Regulation of cyclin D1/Cdk4 complexes by calcium/calmodulin-dependent protein kinase I. 
  • Regulation of the Saccharomyces cerevisiae Slt2 kinase pathway by the stress-inducible Sdp1 dual specificity phosphatase. 
  • RelB cellular regulation and transcriptional activity are regulated by p100. 
  • Renin expression by vascular endothelial cells in culture. 
  • Replication-Competent Influenza B Reporter Viruses as Tools for Screening Antivirals and Antibodies. 
  • Retrograde gene delivery to hypoglossal motoneurons using adeno-associated virus serotype 9. 
  • Rho kinase differentially regulates phosphorylation of nonmuscle myosin II isoforms A and B during cell rounding and migration. 
  • Role of lysophospholipid growth factors in the modulation of aqueous humor outflow facility. 
  • Role of myosin-II phosphorylation in V12Cdc42-mediated disruption of Drosophila cellularization. 
  • Rvs161p and sphingolipids are required for actin repolarization following salt stress. 
  • Ryanodine receptors in muscarinic receptor-mediated bronchoconstriction. 
  • Scaffold-mediated lentiviral transduction for functional tissue engineering of cartilage. 
  • Selective probing and imaging of cells with single walled carbon nanotubes as near-infrared fluorescent molecules. 
  • Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved. 
  • Sertoli cells of the mouse testis originate from the coelomic epithelium. 
  • Sickle erythrocytes target cytotoxics to hypoxic tumor microvessels and potentiate a tumoricidal response. 
  • Simultaneous optical recording of membrane potential and intracellular calcium from brain slices. 
  • Single-detector simultaneous optical mapping of V(m) and [Ca(2+)](i) in cardiac monolayers. 
  • Single-molecule FRET reveals multiscale chromatin dynamics modulated by HP1α. 
  • Small ubiquitin-related modifier-1 modification mediates resolution of CREB-dependent responses to hypoxia. 
  • Soft lithographic functionalization and patterning oxide-free silicon and germanium. 
  • Spatial frequency-domain multiplexed microscopy for simultaneous, single-camera, one-shot, fluorescent, and quantitative-phase imaging. 
  • Spatial tuning of negative and positive Poisson's ratio in a multi-layer scaffold. 
  • Sphingosine-1-phosphate enhancement of cortical actomyosin organization in cultured human Schlemm's canal endothelial cell monolayers. 
  • Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis. 
  • Steady-state fluorescence imaging of neoplasia. 
  • Stretching fibronectin. 
  • Structural and Functional Analyses Reveal Insights into the Molecular Properties of the Escherichia coli Z Ring Stabilizing Protein, ZapC. 
  • Structural basement membrane components and corresponding integrins in Schlemm's canal endothelia. 
  • Structured Illumination Microscopy and a Quantitative Image Analysis for the Detection of Positive Margins in a Pre-Clinical Genetically Engineered Mouse Model of Sarcoma. 
  • Substrate Selectivity of Lysophospholipid Transporter LplT Involved in Membrane Phospholipid Remodeling in Escherichia coli. 
  • Supersensitive Ras activation in dendrites and spines revealed by two-photon fluorescence lifetime imaging. 
  • Suppression of trkB expression by antisense oligonucleotides alters a neuronal phenotype in the rod pathway of the developing rat retina. 
  • Suprastructures and dynamic properties of Mycobacterium tuberculosis FtsZ. 
  • Surface-expressed invariant chain (CD74) is required for internalization of human leucocyte antigen-DR molecules to early endosomal compartments. 
  • Survival of retinal pigment epithelium after exposure to prolonged oxidative injury: a detailed gene expression and cellular analysis. 
  • Sustained activation of mTORC1 in macrophages increases AMPKα-dependent autophagy to maintain cellular homeostasis. 
  • Swe1p responds to cytoskeletal perturbation, not bud size, in S. cerevisiae. 
  • Swine lungs expressing human complement-regulatory proteins are protected against acute pulmonary dysfunction in a human plasma perfusion model. 
  • TRPV4 initiates the acute calcium-dependent permeability increase during ventilator-induced lung injury in isolated mouse lungs. 
  • Targeting a genetically engineered elastin-like polypeptide to solid tumors by local hyperthermia. 
  • Telomerase reverse transcriptase is required for the localization of telomerase RNA to cajal bodies and telomeres in human cancer cells. 
  • Temporal relationships of statin and terminin expression in ventral lobe of rat prostate following castration. 
  • Testis development requires the repression of Wnt4 by Fgf signaling. 
  • Tethering telomeric double- and single-stranded DNA-binding proteins inhibits telomere elongation. 
  • The CD14 receptor does not mediate entry of Mycobacterium tuberculosis into human mononuclear phagocytes. 
  • The Drosophila claret segregation protein is a minus-end directed motor molecule. 
  • The Meckel syndrome- associated protein MKS1 functionally interacts with components of the BBSome and IFT complexes to mediate ciliary trafficking and hedgehog signaling. 
  • The Meckel-Gruber Syndrome proteins MKS1 and meckelin interact and are required for primary cilium formation. 
  • The angiotensin II type I receptor-associated protein, ATRAP, is a transmembrane protein and a modulator of angiotensin II signaling. 
  • The ankyrin-B C-terminal domain determines activity of ankyrin-B/G chimeras in rescue of abnormal inositol 1,4,5-trisphosphate and ryanodine receptor distribution in ankyrin-B (-/-) neonatal cardiomyocytes. 
  • The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase Iepsilon. 
  • The class III variant of the epidermal growth factor receptor (EGFRvIII): characterization and utilization as an immunotherapeutic target. 
  • The effect of soluble complement receptor type 1 on hyperacute rejection of porcine xenografts. 
  • The effect of soluble complement receptor type 1 on hyperacute xenograft rejection. 
  • The generation and characterization of novel Col1a1FRT-Cre-ER-T2-FRT and Col1a1FRT-STOP-FRT-Cre-ER-T2 mice for sequential mutagenesis. 
  • The importance of a multifaceted approach to characterizing the microbial flora of chronic wounds. 
  • The kinase inhibitor SFV785 dislocates dengue virus envelope protein from the replication complex and blocks virus assembly. 
  • The mammalian Rad24 homologous to yeast Saccharomyces cerevisiae Rad24 and Schizosaccharomyces pombe Rad17 is involved in DNA damage checkpoint. 
  • The neurodegenerative disease protein ataxin-1 antagonizes the neuronal survival function of myocyte enhancer factor-2. 
  • The nucleic acid scavenger polyamidoamine third-generation dendrimer inhibits fibroblast activation and granulation tissue contraction. 
  • The obligate intracellular pathogen Chlamydia trachomatis targets host lipid droplets. 
  • The oral iron chelator deferiprone protects against iron overload-induced retinal degeneration. 
  • The phosphorylation of vascular endothelial growth factor receptor-2 (VEGFR-2) by engineered surfaces with electrostatically or covalently immobilized VEGF. 
  • The presence of human papillomavirus-16/-18 E6, p53, and Bcl-2 protein in cervicovaginal smears from patients with invasive cervical cancer. 
  • The role of the prostaglandin EP4 receptor in the regulation of human outflow facility. 
  • Thrombotic microangiopathy in anti-glomerular basement membrane glomerulonephritis. 
  • Thyroid hormone induction of mitochondrial activity is coupled to mitophagy via ROS-AMPK-ULK1 signaling. 
  • Total internal reflection fluorescence (TIRF) microscopy. I. Modelling cell contact region fluorescence. 
  • Total internal reflection fluorescence microscopy (TIRFM). II. Topographical mapping of relative cell/substratum separation distances. 
  • Total internal reflection microscopy and atomic force microscopy (TIRFM-AFM) to study stress transduction mechanisms in endothelial cells. 
  • Transbilayer peptide sorting between raft and nonraft bilayers: comparisons of detergent extraction and confocal microscopy. 
  • Transfer of molecules from glia to axon in the squid may be mediated by glial vesicles. 
  • Treatment of Inherited Eye Defects by Systemic Hematopoietic Stem Cell Transplantation. 
  • Treatment with Imatinib in NSCLC is associated with decrease of phosphorylated PDGFR-beta and VEGF expression, decrease in interstitial fluid pressure and improvement of oxygenation. 
  • Tumor-specific anti-epidermal growth factor receptor variant III monoclonal antibodies: use of the tyramine-cellobiose radioiodination method enhances cellular retention and uptake in tumor xenografts. 
  • Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors. 
  • Two-dimensional fluorescence intensity distribution analysis: theory and applications. 
  • Tyrosine-dependent basolateral targeting of human connexin43-eYFP in Madin-Darby canine kidney cells can be disrupted by the oculodentodigital dysplasia mutation L90V. 
  • Up-regulated P21CIP1 expression is part of the regulation quantitatively controlling serum deprivation-induced apoptosis. 
  • Use of phage display to identify novel mineralocorticoid receptor-interacting proteins. 
  • Variations on the single-molecule assay for microtubule-associated proteins and kinesins. 
  • Vascular permeability in a human tumour xenograft: molecular charge dependence. 
  • Vasoactive intestinal peptide, forskolin, and genistein increase apical CFTR trafficking in the rectal gland of the spiny dogfish, Squalus acanthias. Acute regulation of CFTR trafficking in an intact epithelium. 
  • Vasoactive intestinal polypeptide type-1 receptor regulation. Desensitization, phosphorylation, and sequestration. 
  • Visualization and characterization of inflammatory cell recruitment and migration through the corneal stroma in endotoxin-induced keratitis. 
  • Visualization of neuromuscular junctions over periods of several months in living mice. 
  • Visualizing G protein-coupled receptor signalsomes using confocal immunofluorescence microscopy. 
  • Vitamin D(3) cryosensitization increases prostate cancer susceptibility to cryoablation via mitochondrial-mediated apoptosis and necrosis. 
  • Wound healing: The power of the purse string. 
  • Zebrafish assays of ciliopathies. 
  • [A severe course of bullous pemphigoid in a young man]. 
  • alpha-Crystallin localizes to the leading edges of migrating lens epithelial cells. 
  • beta -Arrestin-mediated recruitment of the Src family kinase Yes mediates endothelin-1-stimulated glucose transport. 
  • beta -Arrestins regulate protease-activated receptor-1 desensitization but not internalization or Down-regulation. 
  • beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor. 
  • cPLA2 regulates the expression of type I interferons and intracellular immunity to Chlamydia trachomatis. 
  • zipper Nonmuscle myosin-II functions downstream of PS2 integrin in Drosophila myogenesis and is necessary for myofibril formation. 
• 

  Keywords of People

  • Badea, Cristian Tudorel, Professor in Radiology, Biomedical Engineering
  • Bejsovec, Amy, Associate Professor of Biology, Biology
  • Bennett, Vann, George B. Geller Professor for Research in Molecular Biology in the School of Medicine, Duke Cancer Institute
  • Bowes Rickman, Catherine, Associate Professor of Ophthalmology, Cell Biology
  • Bradford, William Dalton, Professor of Pathology, Pathology
  • Calakos, Nicole, Professor in Neurology, Duke Science & Society
  • Craciunescu, Oana, Associate Professor of Radiation Oncology, Radiation Oncology
  • Davis, Erica Ellen, Associate Professor of Pediatrics, Cell Biology
  • Erickson, Harold Paul, James B. Duke Professor of Cell Biology, Biomedical Engineering
  • Juvvadi, Praveen Rao, Assistant Professor in Pediatrics, Pediatrics, Infectious Diseases
  • Karhausen, Jorn, Assistant Professor of Anesthesiology, Anesthesiology, Cardiothoracic
  • Nielsen, Karen Cristina, Associate Professor of Anesthesiology, Anesthesiology, Ambulatory
  • Palmer, Gregory M., Associate Professor of Radiation Oncology, Radiation Oncology
  • Steinbach, William J., Professor of Pediatrics, Molecular Genetics and Microbiology
  • Stinnett, Sandra Sue, Associate Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics
  • Sullivan, Beth Ann, Associate Professor of Molecular Genetics and Microbiology, Duke Science & Society
  • Taylor, Gregory Alan, Associate Professor in Medicine, Immunology
  • Warner, David Samuel, Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology
  • Wax, Adam P., Professor of Biomedical Engineering, Biomedical Engineering
  • Zennadi, Rahima, Associate Professor in Medicine, Medicine, Hematology
  • Zhang, Zhiquan, Assistant Professor in Anesthesiology, Anesthesiology
  • Zhong, Xiaoping, Professor of Pediatrics, Immunology