Microsomes

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  Subject Areas on Research

  • (3H)norepinephrine binding: unrelated to catechol-O-methyl transferase. 
  • A fraction of the ventricular myocardium that has the specificity of the cardiac beta-adrenergic receptor. 
  • A free radical mechanism of prostaglandin synthase-dependent aminopyrine demethylation. 
  • Acetyl-CoA:1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase is directly activated by p38 kinase. 
  • Activities of the initial enzymes of glycerolipid and sphingolipid synthesis in lung microsomes from rats exposed to air or 85% oxygen. 
  • Acyl-CoAs are functionally channeled in liver: potential role of acyl-CoA synthetase. 
  • Adipocyte beta-adrenergic receptors. Identification and subcellular localization by (-)-[3H]dihydroalprenolol binding. 
  • Affinity chromatography of adrenergic receptors and binding proteins. 
  • Amino acid permeases require COPII components and the ER resident membrane protein Shr3p for packaging into transport vesicles in vitro. 
  • Application of proteomic marker ensembles to subcellular organelle identification. 
  • Assembly of the dystrophin-associated protein complex does not require the dystrophin COOH-terminal domain. 
  • Assembly of translocation-competent proteoliposomes from detergent-solubilized rough microsomes. 
  • Biochemical and cytochemical comparison of surface membranes from normal and dystrophic chickens. 
  • Biochemical fractionation and assembly of the membrane components that mediate nascent chain targeting and translocation. 
  • Biosynthesis of renin: multiplicity of active and intermediate forms. 
  • Calcium accumulation by isolated sarcoplasmic reticulum of skeletal muscle during development in tissue culture. 
  • Ceramide synthase. 
  • Chick microsomal oxidases. Isolation, properties, and stimulation by embryonic exposure to 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane. 
  • Cholesterol interaction with the daunorubicin binding site of P-glycoprotein. 
  • Coal fly ash induces hepatic and pulmonary cytochrome P-450 and sigma-aminolevulinic acid synthetase in rats. 
  • Cysteine-3635 is responsible for skeletal muscle ryanodine receptor modulation by NO. 
  • Debromination of polybrominated diphenyl ether-99 (BDE-99) in carp (Cyprinus carpio) microflora and microsomes. 
  • Diversity in membrane binding sites of ankyrins. Brain ankyrin, erythrocyte ankyrin, and processed erythrocyte ankyrin associate with distinct sites in kidney microsomes. 
  • Effects of DDT on eggshell quality and calcium adenosine triphosphatase. 
  • Effects of inhibition and induction of cytochrome P-450 isozymes on hyperoxic lung injury in rats. 
  • Effects of phenethyl isothiocyanate, a carcinogenesis inhibitor, on xenobiotic-metabolizing enzymes and nitrosamine metabolism in rats. 
  • Evidence for two cellular pathways of renin secretion by the mouse submandibular gland. 
  • Fentanyl metabolism by human hepatic and intestinal cytochrome P450 3A4: implications for interindividual variability in disposition, efficacy, and drug interactions. 
  • Genes for apolipoprotein B and microsomal triglyceride transfer protein are expressed in the heart: evidence that the heart has the capacity to synthesize and secrete lipoproteins. 
  • Human enteric microsomal CYP4F enzymes O-demethylate the antiparasitic prodrug pafuramidine. 
  • Human kidney methoxyflurane and sevoflurane metabolism. Intrarenal fluoride production as a possible mechanism of methoxyflurane nephrotoxicity. 
  • Identification of a novel stage of ribosome/nascent chain association with the endoplasmic reticulum membrane. 
  • Identification of the cardiac beta-adrenergic receptor protein: solubilization and purification by affinity chromatography. 
  • In vitro and tissue culture methods for analysis of translation initiation on the endoplasmic reticulum. 
  • In vitro inhibition of microsomal calcium atpase from eggshell gland of mallard duck. 
  • In vitro metabolism of cyclosporine A by human kidney CYP3A5. 
  • In vitro metabolism of the COX-2 inhibitor DFU, including a novel glutathione adduct rearomatization. 
  • Induction of phosphatidylcholine biosynthesis via CDPcholine pathway in lung and liver of rats following intratracheal administration of DDT and endosulfan. 
  • Isolated beta-adrenergic binding sites: a potential assay vehicle for catecholamines. 
  • Isolated hormone receptors: physiologic and clinical implications. 
  • Lumenal proteins of the mammalian endoplasmic reticulum are required to complete protein translocation. 
  • Lung subcellular fractions and surfactant lipid metabolism of rats exposed with DDT or endosulfan intratracheally. 
  • Membrane topology and biogenesis of eukaryotic signal peptidase. 
  • Metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) by human CYP1B1 genetic variants. 
  • Metabolism of alfentanil by cytochrome p4503a (cyp3a) enzymes. 
  • Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation. 
  • Microparticles stimulate the synthesis of prostaglandin E(2) via induction of cyclooxygenase 2 and microsomal prostaglandin E synthase 1. 
  • Microsomal membranes contain a high affinity binding site for prenylated peptides. 
  • New lessons in the regulation of glucose metabolism taught by the glucose 6-phosphatase system. 
  • Nicotine oxidation by genetic variants of CYP2B6 and in human brain microsomes. 
  • On the occurrence of cytochrome P-450 and aryl hydrocarbon hydroxylase activity in rat brain. 
  • Phosphatidylcholine metabolism in lung microsomes and lung surfactant of rats exposed intratracheally to coal fly ash. 
  • Placental lactogen and growth hormone receptors in human fetal tissues: relationship to fetal plasma human placental lactogen concentrations and fetal growth. 
  • Prenylated peptides in identification of specific binding proteins. 
  • Progesterone Metabolites Produced by Cytochrome P450 3A Modulate Uterine Contractility in a Murine Model. 
  • Proteolytic domains of the epidermal growth factor receptor of human placenta. 
  • Proteomic analysis of mitochondrial-associated ER membranes (MAM) during RNA virus infection reveals dynamic changes in protein and organelle trafficking. 
  • Reconstitution of secretory protein translocation from detergent-solubilized rough microsomes. 
  • Release of [3H]norepinephrine from synaptic vesicles isolated from rat brain after the intracisternal administration of [3H]norepinephrine: influence of nucleotides, ions and drugs, and destabilization of transmitter storage caused by acute or chronic lithium administration. 
  • Ribosome-independent regulation of translocon composition and Sec61alpha conformation. 
  • Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles. 
  • Role of hepatic and intestinal cytochrome P450 3A and 2B6 in the metabolism, disposition, and miotic effects of methadone. 
  • Specific binding of -adrenergic catecholamines to a subcellular fraction from cardiac muscle. 
  • Structure and folding of nascent polypeptide chains during protein translocation in the endoplasmic reticulum. 
  • Structure-activity relationships of arylalkyl isothiocyanates for the inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism and the modulation of xenobiotic-metabolizing enzymes in rats and mice. 
  • Subcellular distribution of transmitter-related enzyme activities in discrete areas of the rat dentate gyrus. 
  • The common variant of cystic fibrosis transmembrane conductance regulator is recognized by hsp70 and degraded in a pre-Golgi nonlysosomal compartment. 
  • The impact of microsomal prostaglandin e synthase 1 on blood pressure is determined by genetic background. 
  • The inhibition of human adrenal steroidogenic enzyme activities by suramin. 
  • The nature of renin precursor and inactive renin. 
  • The signal sequence receptor, unlike the signal recognition particle receptor, is not essential for protein translocation. 
  • The synthesis and secretion of gamma-globulin by lymph node cells. V. The dissociation of the microsome-antibody complex with enzymatically and chemically altered gamma-globulins. 
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  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute