Microspheres

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  Subject Areas on Research

  • A Phase I safety and immunogenicity trial of UBI microparticulate monovalent HIV-1 MN oral peptide immunogen with parenteral boost in HIV-1 seronegative human subjects. 
  • A centrifugal fluidic immunoassay for ocular diagnostics with an enzymatically hydrolyzed fluorogenic substrate. 
  • A moldable sustained release bupivacaine formulation for tailored treatment of postoperative dental pain. 
  • A synthetic mimic of the secretory granule for drug delivery. 
  • A technique to inject microspheres into the left atrium of awake dogs without thoracotomy. 
  • Aberrant interaction of B-cell lymphocytic leukemia cells with antibody coated polyacrylamide beads. 
  • Acoustofluidic coating of particles and cells. 
  • Analysis of implantation in assisted reproduction through the use of serial human chorionic gonadotropin measurements. 
  • Anatomical and physiological localization of prelabeled grafts in rat hippocampus. 
  • Angiopellosis as an Alternative Mechanism of Cell Extravasation. 
  • Antibody binding to a conformation-dependent epitope induces L-selectin association with the detergent-resistant cytoskeleton. 
  • Application of Bayesian modeling of autologous antibody responses against ovarian tumor-associated antigens to cancer detection. 
  • Assessment of renal blood flow with contrast ultrasonography. 
  • Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor. 
  • BEAMing: single-molecule PCR on microparticles in water-in-oil emulsions. 
  • Bariatric embolization for suppression of the hunger hormone ghrelin in a porcine model. 
  • Cardiac cryosurgery: regional myocardial blood flow of ventricular cryolesions. 
  • Carotid artery injections in 40- to 99-g Fischer rats: technical note and evaluation of blood flow by various injection techniques. 
  • Case 2--1997. On-line contrast echocardiographic assessment of myocardial perfusion: its role in minimally invasive coronary artery bypass procedures. 
  • Case report: optimizing intraoperative detection of pulmonary embolism using contrast-enhanced echocardiography. 
  • Characterization of novel microsphere chain fiber optic tips for potential use in ophthalmic laser surgery. 
  • Chemical sintering generates uniform porous hyaluronic acid hydrogels 
  • Colloidal gold fluorescent microspheres: a new retrograde marker visualized by light and electron microscopy. 
  • Combined systemic and mucosal immunization with microsphere-encapsulated inactivated simian immunodeficiency virus elicits serum, vaginal, and tracheal antibody responses in female rhesus macaques. 
  • Comparison of PSGL-1 microbead and neutrophil rolling: microvillus elongation stabilizes P-selectin bond clusters. 
  • Comparison of antibiotic beads and intravenous antibiotics in open fractures. 
  • Contact focusing multimodal microprobes for ultraprecise laser tissue surgery. 
  • Contrast echocardiography: influence of ultrasonic machine settings, mixing conditions, and pressurization on pixel intensity and microsphere size of Albunex solutions in vitro. 
  • DNA transfection of macaque and murine respiratory tissue is greatly enhanced by use of a nuclease inhibitor. 
  • Detachable microsphere scalpel tips for potential use in ophthalmic surgery with the erbium:YAG laser. 
  • Detection of pulmonary emboli in dogs: comparison of single photon emission computed tomography, gamma camera imaging, and angiography. 
  • Development and optimization of a dual-photoinitiator, emulsion-based technique for rapid generation of cell-laden hydrogel microspheres. 
  • Development of a fluorescent microsphere technique for rapid histological determination of cerebral blood flow. 
  • Direct observation of kinesin stepping by optical trapping interferometry. 
  • Distribution of 15- and 137-mu diameter microspheres in the dog lung in the axial plane. 
  • Effect of basic fibroblast growth factor on myocardial angiogenesis in dogs with mature collateral vessels. 
  • Effect of fluorocarbon-for-blood exchange on regional cerebral blood flow in rats. 
  • Effectiveness of switching from long-acting injectable fluphenazine or haloperidol decanoate to long-acting injectable risperidone microspheres: an open-label, randomized controlled trial. 
  • Effects of 10-hydroxycamptothecin, delivered from locally injectable poly(lactide-co-glycolide) microspheres, in a murine human oral squamous cell carcinoma regression model. 
  • Effects of a Single Intra-Articular Injection of a Microsphere Formulation of Triamcinolone Acetonide on Knee Osteoarthritis Pain: A Double-Blinded, Randomized, Placebo-Controlled, Multinational Study. 
  • Effects of anemia and hypotension on porcine optic nerve blood flow and oxygen delivery. 
  • Embolic microspheres within ovarian arterial vasculature after uterine artery embolization. 
  • Enhancing human islet transplantation by localized release of trophic factors from PLG scaffolds. 
  • Evaluation of changes in skeletal muscle blood flow in the dog with contrast ultrasonography revisited: has the technique been useful, and where are we headed now? 
  • Experimental verification of T-matrix-based inverse light scattering analysis for assessing structure of spheroids as models of cell nuclei. 
  • Feasibility of field-based light scattering spectroscopy. 
  • Fiber-optic interferometric two-dimensional scattering-measurement system. 
  • Focused ultrasound (HIFU) induces localized enhancement of reporter gene expression in rabbit carotid artery. 
  • Gastroduodenal ulcerations in patients receiving selective hepatic artery infusion chemotherapy. 
  • Glomerular beta-galactosidase expression following transduction with microsphere-adenoviral complexes. 
  • Green fluorescent latex microspheres: a new retrograde tracer. 
  • Hard-sphere crystallization gets rarer with increasing dimension. 
  • Heterogeneity and probabilistic binding contributions to receptor-mediated cell detachment kinetics. 
  • Hydrogel microsphere encapsulation of a cell-based gene therapy system increases cell survival of injected cells, transgene expression, and bone volume in a model of heterotopic ossification. 
  • Hyperpolarized 3He microspheres as a novel vascular signal source for MRI. 
  • Identification of fluorescent beads using a coded aperture snapshot spectral imager. 
  • Immunomagnetic selection of purified monocyte and lymphocyte populations from peripheral blood mononuclear cells following cryopreservation. 
  • Immunopharmacologic purging of breast cancer from bone marrow for autologous bone marrow transplantation. 
  • Impact of Late Dosing on Testosterone Suppression with 2 Different Leuprolide Acetate Formulations: In Situ Gel and Microsphere. An Analysis of United States Clinical Data. 
  • In vitro characterization of vascular endothelial growth factor and dexamethasone releasing hydrogels for implantable probe coatings. 
  • Induction of mucosal antibody responses by microsphere-encapsulated formalin-inactivated simian immunodeficiency virus in a male urethral challenge model. 
  • Internally administered isotopes in the treatment of solid malignancy. 
  • Isolation of a mycoplasma-specific binding peptide from an unbiased phage-displayed peptide library. 
  • Large A-fiber activity is required for microglial proliferation and p38 MAPK activation in the spinal cord: different effects of resiniferatoxin and bupivacaine on spinal microglial changes after spared nerve injury. 
  • Laser-induced heating in optical traps. 
  • Latex nanosphere delivery system (LNDS): novel nanometer-sized carriers of fluorescent dyes and active agents selectively target neuronal subpopulations via uptake and retrograde transport. 
  • Lectin and epidermal growth factor domains of P-selectin at physiologic density are the recognition unit for leukocyte binding. 
  • Limits of detection of regional differences in vasodilated flow in viable myocardium by first-pass magnetic resonance perfusion imaging. 
  • Mapping neuronal inputs to REM sleep induction sites with carbachol-fluorescent microspheres. 
  • Mechanical stiffness grades metastatic potential in patient tumor cells and in cancer cell lines. 
  • Microglassification™: a novel technique for protein dehydration. 
  • Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis. 
  • Microvascular integrity and the time course of myocardial sodium accumulation after acute infarction. 
  • Molecular analysis of highly enriched populations of T-cell-depleted monocytes. 
  • Mucosal and systemic anti-HIV responses in rhesus macaques following combinations of intranasal and parenteral immunizations. 
  • Multiplexing superparamagnetic beads driven by multi-frequency ratchets. 
  • Myocardial Gd-DTPA kinetics determine MRI contrast enhancement and reflect the extent and severity of myocardial injury after acute reperfused infarction. 
  • Myocardial blood flow and oxygen consumption in the empty-beating, fibrillating, and potassium-arrested hypertrophied canine heart. 
  • Nerve conduction blockade in the sciatic nerve prevents but does not reverse the activation of p38 mitogen-activated protein kinase in spinal microglia in the rat spared nerve injury model. 
  • Neuroblastoma grafts are noninvasively removed within mouse neocortex by selective laser activation of intracellular photolytic chromophore. 
  • Nitric oxide-releasing polymeric microspheres improve diabetes-related erectile dysfunction. 
  • Opacification and border delineation improvement in patients with suboptimal endocardial border definition in routine echocardiography: results of the Phase III Albunex Multicenter Trial. 
  • Optical tracking of acoustic radiation force impulse-induced dynamics in a tissue-mimicking phantom. 
  • Optimization and qualification of an Fc Array assay for assessments of antibodies against HIV-1/SIV. 
  • Oral vaccine models: multiple delivery systems employing tetanus toxoid. 
  • PLGA and PHBV Microsphere Formulations and Solid-State Characterization: Possible Implications for Local Delivery of Fusidic Acid for the Treatment and Prevention of Orthopaedic Infections 
  • Patterns of excitation and inhibition evoked by horizontal connections in visual cortex share a common relationship to orientation columns. 
  • Pericyte requirement for anti-leak action of angiopoietin-1 and vascular remodeling in sustained inflammation. 
  • Phase separation behavior of fusidic acid and rifampicin in PLGA microspheres. 
  • Phenotypic and functional characterization of cytotoxic T lymphocytes by flow cytometry. 
  • Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles. 
  • Physiological basis of myocardial contrast enhancement in fast magnetic resonance images of 2-day-old reperfused canine infarcts. 
  • Pigment epithelium-derived factor (PEDF) suppresses IL-1β-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling. 
  • Pilot investigation of a novel testing strategy for bleeding in ventricular assist device recipients. 
  • Quantification and time course of microvascular obstruction by contrast-enhanced echocardiography and magnetic resonance imaging following acute myocardial infarction and reperfusion. 
  • Quantifying cellular traction forces in three dimensions. 
  • Quantitation of renal blood flow by contrast ultrasonography: preliminary results. 
  • Randomized Trial of Hepatic Artery Embolization for Hepatocellular Carcinoma Using Doxorubicin-Eluting Microspheres Compared With Embolization With Microspheres Alone. 
  • Rapid healing of femoral defects in rats with low dose sustained BMP2 expression from PEGDA hydrogel microspheres. 
  • Rationale and design of the EXenatide Study of Cardiovascular Event Lowering (EXSCEL) trial. 
  • Recent developments in SWL physics research. 
  • Recurrent pseudobacteremias traced to a radiometric blood culture device. 
  • Regional cerebral blood flow in normal blood circulated and perfluorocarbon transfused rats. 
  • Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. 
  • Relationship of T2-Weighted MRI Myocardial Hyperintensity and the Ischemic Area-At-Risk. 
  • Residual oil fly ash and charged polymers activate epithelial cells and nociceptive sensory neurons. 
  • Retinal blood flow in normal and diabetic dogs. 
  • Rheological properties of living cytoplasm: a preliminary investigation of squid axoplasm (Loligo pealei). 
  • RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration. 
  • Risks versus benefits of different types of long-acting injectable antipsychotics. 
  • SPECT quantification of technetium-99m microspheres within the canine lung. 
  • Safety and efficacy of sonicated albumin microspheres in perfusion and vein graft patency assessments. 
  • Silver nanoparticle-alginate composite beads for point-of-use drinking water disinfection. 
  • Single-Dose Intraventricular Nimodipine Microparticles Versus Oral Nimodipine for Aneurysmal Subarachnoid Hemorrhage. 
  • Single-target molecule detection with nonbleaching multicolor optical immunolabels. 
  • Size and shape determination of spheroidal scatterers using two-dimensional angle resolved scattering. 
  • Spectroscopic optical coherence refraction tomography. 
  • Studies on the inhalation toxicology of two fiberglasses and amosite asbestos in the syrian golden hamster. Part I. Results of a subchronic study and dose selection for a chronic study. 
  • Sustained release of nerve growth factor from biodegradable polymer microspheres. 
  • Synovial and systemic pharmacokinetics (PK) of triamcinolone acetonide (TA) following intra-articular (IA) injection of an extended-release microsphere-based formulation (FX006) or standard crystalline suspension in patients with knee osteoarthritis (OA). 
  • The B cell surface molecule B1 is functionally linked with B cell activation and differentiation. 
  • The effect of cardiopulmonary bypass and inspired oxygen concentration on left ventricular contrast opacification with optison, a second-generation ultrasound contrast agent. 
  • The effect of intra-aortic balloon counterpulsation on left ventricular functional recovery early after acute myocardial infarction: a randomized experimental magnetic resonance imaging study. 
  • The influence of intravenous Albunex injections on pulmonary arterial pressure, gas exchange, and left ventricular peak intensity. 
  • The motion of a single molecule, the lambda-receptor, in the bacterial outer membrane. 
  • The relationship of transmural myocardial blood flow to midwall function. 
  • The reliable targeting of specific drug release profiles by integrating arrays of different albumin-encapsulated microsphere types. 
  • The synchronization of superparamagnetic beads driven by a micro-magnetic ratchet. 
  • Treatment of primary liver tumors with Yttrium-90 microspheres (TheraSphere) in high risk patients: analysis of survival and toxicities. 
  • Trimers of the fibronectin cell adhesion domain localize to actin filament bundles and undergo rearward translocation. 
  • Use of SYTO 13, a fluorescent dye binding nucleic acids, for the detection of microparticles in in vitro systems. 
  • Validation of a Triplex Pharmacokinetic Assay for Simultaneous Quantitation of HIV-1 Broadly Neutralizing Antibodies PGT121, PGDM1400, and VRC07-523-LS. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Preminger, Glenn Michael, James F. Glenn, M.D. Distinguished Professor of Urology, Surgery, Urology
  • Sullivan, Daniel Carl, Professor Emeritus of Radiology, Radiology
  • Virgin, Lawrence N., Professor of Mechanical Engineering and Materials Science, Thomas Lord Department of Mechanical Engineering and Materials Science
  • Wax, Adam P., Professor of Biomedical Engineering, Biomedical Engineering