Microtubule Proteins

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  Subject Areas on Research

  • A Mec17-Myosin II Effector Axis Coordinates Microtubule Acetylation and Actin Dynamics to Control Primary Cilium Biogenesis. 
  • A point mutation in the microtubule binding region of the Ncd motor protein reduces motor velocity. 
  • An N-terminal truncation of the ncd motor protein supports diffusional movement of microtubules in motility assays. 
  • Binding sites on microtubules of kinesin motors of the same or opposite polarity. 
  • Centrosome and spindle function of the Drosophila Ncd microtubule motor visualized in live embryos using Ncd-GFP fusion proteins. 
  • Chromosome distribution, molecular motors and the claret protein. 
  • Enhancement of the ncdD microtubule motor mutant by mutants of alpha Tub67C. 
  • Expression of microtubule motor proteins in bacteria for characterization in in vitro motility assays. 
  • Function of microtubules under inadequate protein diet. 
  • GFP fusions to a microtubule motor protein to visualize meiotic and mitotic spindle dynamics in Drosophila. 
  • Haploidy and androgenesis in Drosophila. 
  • Heterogeneity in the phosphorylation of microtubule-associated protein MAP1B during rat brain development. 
  • Kar3 interaction with Cik1 alters motor structure and function. 
  • Kinesin-5 Kip1 is a bi-directional motor that stabilizes microtubules and tracks their plus-ends in vivo. 
  • Meiosis, mitosis and microtubule motors. 
  • Mutants of the Drosophila ncd microtubule motor protein cause centrosomal and spindle pole defects in mitosis. 
  • Mutants of the microtubule motor protein, nonclaret disjunctional, affect spindle structure and chromosome movement in meiosis and mitosis. 
  • OP18/stathmin binds near the C-terminus of tubulin and facilitates GTP binding. 
  • Purification of kinesin-related protein complexes from eggs and embryos. 
  • Rapid purification of microtubule motor domain proteins expressed in bacteria. 
  • Separation of meiotic and mitotic effects of claret non-disjunctional on chromosome segregation in Drosophila. 
  • Spindle dynamics during meiosis in Drosophila oocytes. 
  • Stathmin-deficient mice develop an age-dependent axonopathy of the central and peripheral nervous systems. 
  • Structural and functional domains of the Drosophila ncd microtubule motor protein. 
  • Targeted inactivation of synaptic HRG4 (UNC119) causes dysfunction in the distal photoreceptor and slow retinal degeneration, revealing a new function. 
  • Temporal association of ORCA/LRWD1 to late-firing origins during G1 dictates heterochromatin replication and organization. 
  • The Drosophila ncd microtubule motor protein is spindle-associated in meiotic and mitotic cells. 
  • The emerging kinesin family of microtubule motor proteins. 
  • The interaction of RGSZ1 with SCG10 attenuates the ability of SCG10 to promote microtubule disassembly. 
  • Yeast Kar3 is a minus-end microtubule motor protein that destabilizes microtubules preferentially at the minus ends. 
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  Keywords of People

  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology