Subject Areas on Research
- A PIK3C3-ankyrin-B-dynactin pathway promotes axonal growth and multiorganelle transport.
- A common ankyrin-G-based mechanism retains KCNQ and NaV channels at electrically active domains of the axon.
- A critical role for the autophagy gene Atg5 in T cell survival and proliferation.
- A new activity of doublecortin in recognition of the phospho-FIGQY tyrosine in the cytoplasmic domain of neurofascin.
- A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease.
- A novel role for the cyclin-dependent kinase inhibitor p27(Kip1) in angiotensin II-stimulated vascular smooth muscle cell hypertrophy.
- A proteomic analysis of human cilia: identification of novel components.
- A role for c-FLIP(L) in the regulation of apoptosis, autophagy, and necroptosis in T lymphocytes.
- ALS- and FTD-associated missense mutations in TBK1 differentially disrupt mitophagy.
- AURKA amplification, chromosome instability, and centrosome abnormality in human pancreatic carcinoma cells.
- Absence of histological lesions in primate models of ECT and magnetic seizure therapy.
- Acute ablation of survivin uncovers p53-dependent mitotic checkpoint functions and control of mitochondrial apoptosis.
- Advanced magnetic resonance imaging of cerebral cavernous malformations: part II. Imaging of lesions in murine models.
- An ankyrin-based mechanism for functional organization of dystrophin and dystroglycan.
- Analysis of the expression, distribution and function of cyclin dependent kinase 5 (cdk5) in developing cerebellar macroneurons.
- Ankyrin-B interactions with spectrin and dynactin-4 are required for dystrophin-based protection of skeletal muscle from exercise injury.
- Ankyrin-G regulates forebrain connectivity and network synchronization via interaction with GABARAP.
- Arl2- and Msps-dependent microtubule growth governs asymmetric division.
- Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks.
- Asymmetric cell divisions promote stratification and differentiation of mammalian skin.
- Autophagic activity dictates the cellular response to oncogenic RAS.
- Autophagy enhances NFκB activity in specific tissue macrophages by sequestering A20 to boost antifungal immunity.
- Autophagy is essential for mitochondrial clearance in mature T lymphocytes.
- Autophagy regulates T lymphocyte proliferation through selective degradation of the cell-cycle inhibitor CDKN1B/p27Kip1.
- Autophagy regulates endoplasmic reticulum homeostasis and calcium mobilization in T lymphocytes.
- Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide.
- B-cyclin/CDKs regulate mitotic spindle assembly by phosphorylating kinesins-5 in budding yeast.
- Biallelic somatic and germline mutations in cerebral cavernous malformations (CCMs): evidence for a two-hit mechanism of CCM pathogenesis.
- Binding sites on microtubules of kinesin motors of the same or opposite polarity.
- CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis.
- CTLA-4-Mediated inhibition of early events of T cell proliferation.
- Ccm1 is required for arterial morphogenesis: implications for the etiology of human cavernous malformations.
- Cerebral cavernous malformations associated with cutaneous angiokeratomas and hemangiomas.
- Characterization of microtubule-associated protein MAP1B: phosphorylation state, light chains, and binding to microtubules.
- Chlamydia trachomatis Is Resistant to Inclusion Ubiquitination and Associated Host Defense in Gamma Interferon-Primed Human Epithelial Cells.
- CoA synthase regulates mitotic fidelity via CBP-mediated acetylation.
- Coevolution of the major histocompatibility complex and the t-complex in the mouse. I. Generation and maintenance of high complementarity associations.
- Coevolution of the major histocompatibility complex and the t-complex in the mouse. II. Modification of response to sharing of histocompatibility antigens.
- Combination of Rad001 (everolimus) and propachlor synergistically induces apoptosis through enhanced autophagy in prostate cancer cells.
- Computational and experimental analyses reveal previously undetected coding exons of the KRIT1 (CCM1) gene.
- Cytokine effects on cortical neuron MAP-2 immunoreactivity: implications for schizophrenia.
- Cytokinesis proteins Tum and Pav have a nuclear role in Wnt regulation.
- De novo and inherited private variants in MAP1B in periventricular nodular heterotopia.
- Deconstructing Pompe disease by analyzing single muscle fibers: to see a world in a grain of sand..
- Decoupling of nucleotide- and microtubule-binding sites in a kinesin mutant.
- Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway.
- Deletions in CCM2 are a common cause of cerebral cavernous malformations.
- Dephosphorylation of distinct sites on microtubule-associated protein MAP1B by protein phosphatases 1, 2A and 2B.
- Depletion of casein kinase II by antisense oligonucleotide prevents neuritogenesis in neuroblastoma cells.
- Desmoplakin: an unexpected regulator of microtubule organization in the epidermis.
- Diazepam promotes ATP recovery and prevents cytochrome c release in hippocampal slices after in vitro ischemia.
- Different spectra of genomic deletions within the CCM genes between Italian and American CCM patient cohorts.
- Differentiation characteristics of newly established medulloblastoma cell lines (D384 Med, D425 Med, and D458 Med) and their transplantable xenografts.
- Disruption of mRNA-RNP formation and sorting to dendritic synapses by antisense oligodeoxynucleotides.
- Distinct roles of Rho1, Cdc42, and Cyk3 in septum formation and abscission during yeast cytokinesis.
- Distinct roles of the co-activators p300 and CBP in retinoic-acid-induced F9-cell differentiation.
- Divergent regulation of functionally distinct γ-tubulin complexes during differentiation.
- Diverse functions within the IAP family.
- Dysregulation of mitochondrial bioenergetics and quality control by HIV-1 Tat in cardiomyocytes.
- E1-like activating enzyme Atg7 is preferentially sequestered into p62 aggregates via its interaction with LC3-I.
- EB1-microtubule interactions in Xenopus egg extracts: role of EB1 in microtubule stabilization and mechanisms of targeting to microtubules.
- Ectopic expression of interferon regulatory factor-1 promotes human breast cancer cell death and results in reduced expression of survivin.
- Effects of JC virus infection on anti-apoptotic protein survivin in progressive multifocal leukoencephalopathy.
- Electron microscopy of MAP 2 (microtubule-associated protein 2).
- Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth.
- Erythrocyte ankyrin: immunoreactive analogues are associated with mitotic structures in cultured cells and with microtubules in brain.
- Evolution in action: giant ankyrins awake.
- Evolution of ASPM coding variation in apes and associations with brain structure in chimpanzees.
- Fasudil decreases lesion burden in a murine model of cerebral cavernous malformation disease.
- Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53.
- Function of tau protein in adult newborn neurons.
- Gene expression profiling and genetic markers in glioblastoma survival.
- Genetic variants in the liver kinase B1-AMP-activated protein kinase pathway genes and pancreatic cancer risk.
- Genetically induced microtubule disruption in the mouse intestine impairs intracellular organization and transport.
- Genetics of cerebral cavernous malformations.
- Giant ankyrin-G stabilizes somatodendritic GABAergic synapses through opposing endocytosis of GABAA receptors.
- Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells.
- Growth factor erv1-like modulates Drp1 to preserve mitochondrial dynamics and function in mouse embryonic stem cells.
- Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.
- HDAC6 is a microtubule-associated deacetylase.
- HPV status-independent association of alcohol and tobacco exposure or prior radiation therapy with promoter methylation of FUSSEL18, EBF3, IRX1, and SEPT9, but not SLC5A8, in head and neck squamous cell carcinomas.
- Heterogeneity in the phosphorylation of microtubule-associated protein MAP1B during rat brain development.
- Highly variable penetrance in subjects affected with cavernous cerebral angiomas (CCM) carrying novel CCM1 and CCM2 mutations.
- How calcium causes microtubule depolymerization.
- How the kinetochore couples microtubule force and centromere stretch to move chromosomes.
- Human IRGM induces autophagy to eliminate intracellular mycobacteria.
- Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by Vitamin B supplementation.
- Identification of cis-suppression of human disease mutations by comparative genomics.
- Impaired photoreceptor protein transport and synaptic transmission in a mouse model of Bardet-Biedl syndrome.
- In situ imaging in C. elegans reveals developmental regulation of microtubule dynamics.
- In vitro neurogenesis by neuronal precursor cells derived from the adult songbird brain.
- Inhibition of Spleen Tyrosine Kinase Potentiates Paclitaxel-Induced Cytotoxicity in Ovarian Cancer Cells by Stabilizing Microtubules.
- Inhibition of isoprenylcysteine carboxylmethyltransferase induces autophagic-dependent apoptosis and impairs tumor growth.
- Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice.
- Inner nuclear envelope proteins SUN1 and SUN2 play a prominent role in the DNA damage response.
- Integrated genomic analyses identify ERRFI1 and TACC3 as glioblastoma-targeted genes.
- Interactions between beta 2-syntrophin and a family of microtubule-associated serine/threonine kinases.
- Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: implications for Alzheimer's disease.
- KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development.
- KRIT1 association with the integrin-binding protein ICAP-1: a new direction in the elucidation of cerebral cavernous malformations (CCM1) pathogenesis.
- Kar3 interaction with Cik1 alters motor structure and function.
- Katanin p60-like1 promotes microtubule growth and terminal dendrite stability in the larval class IV sensory neurons of Drosophila.
- Knocking out lca5 in zebrafish causes cone-rod dystrophy due to impaired outer segment protein trafficking.
- Lesions from patients with sporadic cerebral cavernous malformations harbor somatic mutations in the CCM genes: evidence for a common biochemical pathway for CCM pathogenesis.
- Lis1 is essential for cortical microtubule organization and desmosome stability in the epidermis.
- Localization of differentially phosphorylated isoforms of microtubule-associated protein 1B in cultured rat hippocampal neurons.
- Loss of G(1)/S checkpoint in human immunodeficiency virus type 1-infected cells is associated with a lack of cyclin-dependent kinase inhibitor p21/Waf1.
- Loss of p53 sensitizes mice with a mutation in Ccm1 (KRIT1) to development of cerebral vascular malformations.
- Low frequency of PDCD10 mutations in a panel of CCM3 probands: potential for a fourth CCM locus.
- Low-dose genistein induces cyclin-dependent kinase inhibitors and G(1) cell-cycle arrest in human prostate cancer cells.
- Lysosomal basification and decreased autophagic flux in oxidatively stressed trabecular meshwork cells: implications for glaucoma pathogenesis.
- MTOR-independent induction of autophagy in trabecular meshwork cells subjected to biaxial stretch.
- Maintaining T lymphocyte homeostasis: another duty of autophagy.
- Mammalian septins regulate microtubule stability through interaction with the microtubule-binding protein MAP4.
- Mature Drosophila meiosis I spindles comprise microtubules of mixed polarity.
- Mediation of meiotic and early mitotic chromosome segregation in Drosophila by a protein related to kinesin.
- Microtubule-associated protein 1B (MAP1B) is present in glial cells phosphorylated different than in neurones.
- Microtubule-associated protein 2, a microtubule-associated protein from brain, is immunologically related to the alpha subunit of erythrocyte spectrin.
- Microtubule-associated protein MAP1B showing a fetal phosphorylation pattern is present in sites of neurofibrillary degeneration in brains of Alzheimer's disease patients.
- Microtubule-driven multimerization recruits ase1p onto overlapping microtubules.
- Morphological, biochemical, and genetic support for an apolipoprotein E effect on microtubular metabolism.
- MspI RFLP for microtubule associated protein-2 (MAP2).
- Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity.
- Multiple roles for the active zone protein RIM1alpha in late stages of neurotransmitter release.
- Murine Irgm Paralogs Regulate Nonredundant Functions To Execute Host Defense to Toxoplasma gondii.
- Mutations in a gene encoding a novel protein containing a phosphotyrosine-binding domain cause type 2 cerebral cavernous malformations.
- Mutations in the gene encoding KRIT1, a Krev-1/rap1a binding protein, cause cerebral cavernous malformations (CCM1).
- NMDA-glutamate receptors regulate phosphorylation of dendritic cytoskeletal proteins in the hippocampus.
- Neurosteroid modulation of embryonic neuronal survival in vitro following anoxia.
- Neurotrophic factor-α1 prevents stress-induced depression through enhancement of neurogenesis and is activated by rosiglitazone.
- Novel genetic loci associated with hippocampal volume.
- NuMA localization, stability, and function in spindle orientation involve 4.1 and Cdk1 interactions.
- Pharmacological Inhibition of Lysosomal Activity as a Method For Monitoring Thyroid Hormone-induced Autophagic Flux in Mammalian Cells In Vitro.
- Phenotypic characterization of Bbs4 null mice reveals age-dependent penetrance and variable expressivity.
- Phosphorylated microtubule associated protein (MAP1B-Phos) in the retina during regeneration of the fish optic nerve.
- Phosphorylation of microtubule-associated proteins by protein kinase CK2 in neuritogenesis.
- Prenylation-dependent association of Ki-Ras with microtubules. Evidence for a role in subcellular trafficking.
- Purinergic receptor X7 is a key modulator of metabolic oxidative stress-mediated autophagy and inflammation in experimental nonalcoholic steatohepatitis.
- Quantitative graft integration of fetal hippocampal transplants labeled with 5' bromodeoxyuridine into normal adult hippocampus.
- Quantitative measurement of alternatively spliced amyloid precursor protein mRNA expression in Alzheimer's disease and normal brain by S1 nuclease protection analysis.
- RPGRIP1s with distinct neuronal localization and biochemical properties associate selectively with RanBP2 in amacrine neurons.
- Redirecting Vesicular Transport to Improve Nonviral Delivery of Molecular Cargo.
- Refinement of the PARK3 locus on chromosome 2p13 and the analysis of 14 candidate genes.
- Regulation of mitochondrial morphology by APC/CCdh1-mediated control of Drp1 stability.
- Removal of microglial-specific MyD88 signaling alters dentate gyrus doublecortin and enhances opioid addiction-like behaviors.
- Retinal Ganglion Cells With a Glaucoma OPTN(E50K) Mutation Exhibit Neurodegenerative Phenotypes when Derived from Three-Dimensional Retinal Organoids.
- Role of Inn1 and its interactions with Hof1 and Cyk3 in promoting cleavage furrow and septum formation in S. cerevisiae.
- Role of MAP1B in axonal retrograde transport of mitochondria.
- Role of phosphorylated MAPlB in neuritogenesis.
- Role of the Hof1-Cyk3 interaction in cleavage-furrow ingression and primary-septum formation during yeast cytokinesis.
- Roles for Ndel1 in keratin organization and desmosome function.
- SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice.
- SUN1 is required for telomere attachment to nuclear envelope and gametogenesis in mice.
- SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice.
- Spindle function in yeast: a human motor to the rescue.
- Survivin DNA vaccine generated specific antitumor effects in pancreatic carcinoma and lymphoma mouse models.
- Synapsin I is a microtubule-bundling protein.
- TTBK2 controls cilium stability by regulating distinct modules of centrosomal proteins.
- Tau protein binding forms a 1 nm thick layer along protofilaments without affecting the radial elasticity of microtubules.
- Tau--an inhibitor of deacetylase HDAC6 function.
- Temporal regulation of intracellular organelle homeostasis in T lymphocytes by autophagy.
- The Drosophila claret segregation protein is a minus-end directed motor molecule.
- The E2-like conjugation enzyme Atg3 promotes binding of IRG and Gbp proteins to Chlamydia- and Toxoplasma-containing vacuoles and host resistance.
- The G protein-coupled receptor kinase 2 is a microtubule-associated protein kinase that phosphorylates tubulin.
- The Meckel syndrome- associated protein MKS1 functionally interacts with components of the BBSome and IFT complexes to mediate ciliary trafficking and hedgehog signaling.
- The autophagic protein LC3 translocates to the nucleus and localizes in the nucleolus associated to NUFIP1 in response to cyclic mechanical stress.
- The autophagy gene ATG5 plays an essential role in B lymphocyte development.
- The carboxyl-terminal amino acids render pro-human LC3B migration similar to lipidated LC3B in SDS-PAGE.
- The docking of kinesins, KIF5B and KIF5C, to Ran-binding protein 2 (RanBP2) is mediated via a novel RanBP2 domain.
- The exon junction complex component Magoh controls brain size by regulating neural stem cell division.
- The exoribonuclease Xrn1 is a post-transcriptional negative regulator of autophagy.
- The homotetrameric kinesin-5 KLP61F preferentially crosslinks microtubules into antiparallel orientations.
- The indolocarbazole Gö6976 protects neurons from lipopolysaccharide/interferon-gamma-induced cytotoxicity in murine neuron/glia co-cultures.
- The kinetics of microtubule assembly. Evidence for a two-stage nucleation mechanism.
- The lung is protected from spontaneous inflammation by autophagy in myeloid cells.
- The phosphorylated isoform of microtubule associated protein 1B (MAP1B) is expressed in the visual system of the tench (Tinca tinca, L) during optic nerve regeneration.
- The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis.
- The suppression of testis-brain RNA binding protein and kinesin heavy chain disrupts mRNA sorting in dendrites.
- Thyroid Hormone Stimulation of Autophagy Is Essential for Mitochondrial Biogenesis and Activity in Skeletal Muscle.
- Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy.
- Titin truncations lead to impaired cardiomyocyte autophagy and mitochondrial function in vivo.
- Tolfenamic acid enhances pancreatic cancer cell and tumor response to radiation therapy by inhibiting survivin protein expression.
- Transcriptional regulation of survivin by c-Myc in BCR/ABL-transformed cells: implications in anti-leukaemic strategy.
- Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights.
- Transiently expressed ATG16L1 inhibits autophagosome biogenesis and aberrantly targets RAB11-positive recycling endosomes.
- Tum/RacGAP50C provides a critical link between anaphase microtubules and the assembly of the contractile ring in Drosophila melanogaster.
- VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD.
- Variations on the single-molecule assay for microtubule-associated proteins and kinesins
- Vascular morphogenesis: tales of two syndromes.
- Viral Replication Complexes Are Targeted by LC3-Guided Interferon-Inducible GTPases.
- WIPI1 is a conserved mediator of right ventricular failure.
- Wsp1 is downstream of Cin1 and regulates vesicle transport and actin cytoskeleton as an effector of Cdc42 and Rac1 in Cryptococcus neoformans.
- X-ray crystal structure of the yeast Kar3 motor domain complexed with Mg.ADP to 2.3 A resolution.
- XMAP215 is a long thin molecule that does not increase microtubule stiffness.
- XRN1 stalling in the 5' UTR of Hepatitis C virus and Bovine Viral Diarrhea virus is associated with dysregulated host mRNA stability.
- Yeast Kar3 is a minus-end microtubule motor protein that destabilizes microtubules preferentially at the minus ends.
- p27 and cyclin D1 abnormalities in uterine papillary serous carcinoma.
Keywords of People
- Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
- Ciofani, Maria, Associate Professor of Integrative Immunobiology, Cell Biology
- Lee, Walter T, Professor of Head and Neck Surgery & Communication Sciences, Radiation Oncology
- McLendon, Roger Edwin, Professor of Pathology, Pathology
- Schwartz-Bloom, Rochelle D., Professor Emeritus of Pharmacology & Cancer Biology, Duke Science & Society
- Taylor, Gregory Alan, Professor in Medicine, Integrative Immunobiology