Microtubule-Associated Proteins

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  Subject Areas on Research

  • A PIK3C3-ankyrin-B-dynactin pathway promotes axonal growth and multiorganelle transport. 
  • A common ankyrin-G-based mechanism retains KCNQ and NaV channels at electrically active domains of the axon. 
  • A critical role for the autophagy gene Atg5 in T cell survival and proliferation. 
  • A new activity of doublecortin in recognition of the phospho-FIGQY tyrosine in the cytoplasmic domain of neurofascin. 
  • A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease. 
  • A novel role for the cyclin-dependent kinase inhibitor p27(Kip1) in angiotensin II-stimulated vascular smooth muscle cell hypertrophy. 
  • A proteomic analysis of human cilia: identification of novel components. 
  • A role for c-FLIP(L) in the regulation of apoptosis, autophagy, and necroptosis in T lymphocytes. 
  • ALS- and FTD-associated missense mutations in TBK1 differentially disrupt mitophagy. 
  • AURKA amplification, chromosome instability, and centrosome abnormality in human pancreatic carcinoma cells. 
  • Absence of histological lesions in primate models of ECT and magnetic seizure therapy. 
  • Acute ablation of survivin uncovers p53-dependent mitotic checkpoint functions and control of mitochondrial apoptosis. 
  • Advanced magnetic resonance imaging of cerebral cavernous malformations: part II. Imaging of lesions in murine models. 
  • An ankyrin-based mechanism for functional organization of dystrophin and dystroglycan. 
  • Analysis of the expression, distribution and function of cyclin dependent kinase 5 (cdk5) in developing cerebellar macroneurons. 
  • Ankyrin-B interactions with spectrin and dynactin-4 are required for dystrophin-based protection of skeletal muscle from exercise injury. 
  • Ankyrin-G regulates forebrain connectivity and network synchronization via interaction with GABARAP. 
  • Arl2- and Msps-dependent microtubule growth governs asymmetric division. 
  • Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks. 
  • Asymmetric cell divisions promote stratification and differentiation of mammalian skin. 
  • Autophagic activity dictates the cellular response to oncogenic RAS. 
  • Autophagy enhances NFκB activity in specific tissue macrophages by sequestering A20 to boost antifungal immunity. 
  • Autophagy is essential for mitochondrial clearance in mature T lymphocytes. 
  • Autophagy regulates T lymphocyte proliferation through selective degradation of the cell-cycle inhibitor CDKN1B/p27Kip1. 
  • Autophagy regulates endoplasmic reticulum homeostasis and calcium mobilization in T lymphocytes. 
  • Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide. 
  • B-cyclin/CDKs regulate mitotic spindle assembly by phosphorylating kinesins-5 in budding yeast. 
  • Biallelic somatic and germline mutations in cerebral cavernous malformations (CCMs): evidence for a two-hit mechanism of CCM pathogenesis. 
  • Binding sites on microtubules of kinesin motors of the same or opposite polarity. 
  • CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis. 
  • CTLA-4-Mediated inhibition of early events of T cell proliferation. 
  • Ccm1 is required for arterial morphogenesis: implications for the etiology of human cavernous malformations. 
  • Cerebral cavernous malformations associated with cutaneous angiokeratomas and hemangiomas. 
  • Characterization of microtubule-associated protein MAP1B: phosphorylation state, light chains, and binding to microtubules. 
  • Chlamydia trachomatis Is Resistant to Inclusion Ubiquitination and Associated Host Defense in Gamma Interferon-Primed Human Epithelial Cells. 
  • CoA synthase regulates mitotic fidelity via CBP-mediated acetylation. 
  • Coevolution of the major histocompatibility complex and the t-complex in the mouse. I. Generation and maintenance of high complementarity associations. 
  • Coevolution of the major histocompatibility complex and the t-complex in the mouse. II. Modification of response to sharing of histocompatibility antigens. 
  • Combination of Rad001 (everolimus) and propachlor synergistically induces apoptosis through enhanced autophagy in prostate cancer cells. 
  • Computational and experimental analyses reveal previously undetected coding exons of the KRIT1 (CCM1) gene. 
  • Cytokine effects on cortical neuron MAP-2 immunoreactivity: implications for schizophrenia. 
  • Cytokinesis proteins Tum and Pav have a nuclear role in Wnt regulation. 
  • De novo and inherited private variants in MAP1B in periventricular nodular heterotopia. 
  • Deconstructing Pompe disease by analyzing single muscle fibers: to see a world in a grain of sand.. 
  • Decoupling of nucleotide- and microtubule-binding sites in a kinesin mutant. 
  • Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway. 
  • Deletions in CCM2 are a common cause of cerebral cavernous malformations. 
  • Dephosphorylation of distinct sites on microtubule-associated protein MAP1B by protein phosphatases 1, 2A and 2B. 
  • Depletion of casein kinase II by antisense oligonucleotide prevents neuritogenesis in neuroblastoma cells. 
  • Desmoplakin: an unexpected regulator of microtubule organization in the epidermis. 
  • Diazepam promotes ATP recovery and prevents cytochrome c release in hippocampal slices after in vitro ischemia. 
  • Different spectra of genomic deletions within the CCM genes between Italian and American CCM patient cohorts. 
  • Differentiation characteristics of newly established medulloblastoma cell lines (D384 Med, D425 Med, and D458 Med) and their transplantable xenografts. 
  • Disruption of mRNA-RNP formation and sorting to dendritic synapses by antisense oligodeoxynucleotides. 
  • Distinct roles of Rho1, Cdc42, and Cyk3 in septum formation and abscission during yeast cytokinesis. 
  • Distinct roles of the co-activators p300 and CBP in retinoic-acid-induced F9-cell differentiation. 
  • Divergent regulation of functionally distinct γ-tubulin complexes during differentiation. 
  • Diverse functions within the IAP family. 
  • Dysregulation of mitochondrial bioenergetics and quality control by HIV-1 Tat in cardiomyocytes. 
  • E1-like activating enzyme Atg7 is preferentially sequestered into p62 aggregates via its interaction with LC3-I. 
  • EB1-microtubule interactions in Xenopus egg extracts: role of EB1 in microtubule stabilization and mechanisms of targeting to microtubules. 
  • Ectopic expression of interferon regulatory factor-1 promotes human breast cancer cell death and results in reduced expression of survivin. 
  • Effects of JC virus infection on anti-apoptotic protein survivin in progressive multifocal leukoencephalopathy. 
  • Electron microscopy of MAP 2 (microtubule-associated protein 2). 
  • Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth. 
  • Erythrocyte ankyrin: immunoreactive analogues are associated with mitotic structures in cultured cells and with microtubules in brain. 
  • Evolution in action: giant ankyrins awake. 
  • Evolution of ASPM coding variation in apes and associations with brain structure in chimpanzees. 
  • Fasudil decreases lesion burden in a murine model of cerebral cavernous malformation disease. 
  • Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53. 
  • Function of tau protein in adult newborn neurons. 
  • Gene expression profiling and genetic markers in glioblastoma survival. 
  • Genetic variants in the liver kinase B1-AMP-activated protein kinase pathway genes and pancreatic cancer risk. 
  • Genetically induced microtubule disruption in the mouse intestine impairs intracellular organization and transport. 
  • Genetics of cerebral cavernous malformations. 
  • Giant ankyrin-G stabilizes somatodendritic GABAergic synapses through opposing endocytosis of GABAA receptors. 
  • Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells. 
  • Growth factor erv1-like modulates Drp1 to preserve mitochondrial dynamics and function in mouse embryonic stem cells. 
  • Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. 
  • HDAC6 is a microtubule-associated deacetylase. 
  • HPV status-independent association of alcohol and tobacco exposure or prior radiation therapy with promoter methylation of FUSSEL18, EBF3, IRX1, and SEPT9, but not SLC5A8, in head and neck squamous cell carcinomas. 
  • Heterogeneity in the phosphorylation of microtubule-associated protein MAP1B during rat brain development. 
  • Highly variable penetrance in subjects affected with cavernous cerebral angiomas (CCM) carrying novel CCM1 and CCM2 mutations. 
  • How calcium causes microtubule depolymerization. 
  • How the kinetochore couples microtubule force and centromere stretch to move chromosomes. 
  • Human IRGM induces autophagy to eliminate intracellular mycobacteria. 
  • Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by Vitamin B supplementation. 
  • Identification of cis-suppression of human disease mutations by comparative genomics. 
  • Impaired photoreceptor protein transport and synaptic transmission in a mouse model of Bardet-Biedl syndrome. 
  • In situ imaging in C. elegans reveals developmental regulation of microtubule dynamics. 
  • In vitro neurogenesis by neuronal precursor cells derived from the adult songbird brain. 
  • Inhibition of Spleen Tyrosine Kinase Potentiates Paclitaxel-Induced Cytotoxicity in Ovarian Cancer Cells by Stabilizing Microtubules. 
  • Inhibition of isoprenylcysteine carboxylmethyltransferase induces autophagic-dependent apoptosis and impairs tumor growth. 
  • Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice. 
  • Inner nuclear envelope proteins SUN1 and SUN2 play a prominent role in the DNA damage response. 
  • Integrated genomic analyses identify ERRFI1 and TACC3 as glioblastoma-targeted genes. 
  • Interactions between beta 2-syntrophin and a family of microtubule-associated serine/threonine kinases. 
  • Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: implications for Alzheimer's disease. 
  • KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development. 
  • KRIT1 association with the integrin-binding protein ICAP-1: a new direction in the elucidation of cerebral cavernous malformations (CCM1) pathogenesis. 
  • Kar3 interaction with Cik1 alters motor structure and function. 
  • Katanin p60-like1 promotes microtubule growth and terminal dendrite stability in the larval class IV sensory neurons of Drosophila. 
  • Knocking out lca5 in zebrafish causes cone-rod dystrophy due to impaired outer segment protein trafficking. 
  • Lesions from patients with sporadic cerebral cavernous malformations harbor somatic mutations in the CCM genes: evidence for a common biochemical pathway for CCM pathogenesis. 
  • Lis1 is essential for cortical microtubule organization and desmosome stability in the epidermis. 
  • Localization of differentially phosphorylated isoforms of microtubule-associated protein 1B in cultured rat hippocampal neurons. 
  • Loss of G(1)/S checkpoint in human immunodeficiency virus type 1-infected cells is associated with a lack of cyclin-dependent kinase inhibitor p21/Waf1. 
  • Loss of p53 sensitizes mice with a mutation in Ccm1 (KRIT1) to development of cerebral vascular malformations. 
  • Low frequency of PDCD10 mutations in a panel of CCM3 probands: potential for a fourth CCM locus. 
  • Low-dose genistein induces cyclin-dependent kinase inhibitors and G(1) cell-cycle arrest in human prostate cancer cells. 
  • Lysosomal basification and decreased autophagic flux in oxidatively stressed trabecular meshwork cells: implications for glaucoma pathogenesis. 
  • MTOR-independent induction of autophagy in trabecular meshwork cells subjected to biaxial stretch. 
  • Maintaining T lymphocyte homeostasis: another duty of autophagy. 
  • Mammalian septins regulate microtubule stability through interaction with the microtubule-binding protein MAP4. 
  • Mature Drosophila meiosis I spindles comprise microtubules of mixed polarity. 
  • Mediation of meiotic and early mitotic chromosome segregation in Drosophila by a protein related to kinesin. 
  • Microtubule-associated protein 1B (MAP1B) is present in glial cells phosphorylated different than in neurones. 
  • Microtubule-associated protein 2, a microtubule-associated protein from brain, is immunologically related to the alpha subunit of erythrocyte spectrin. 
  • Microtubule-associated protein MAP1B showing a fetal phosphorylation pattern is present in sites of neurofibrillary degeneration in brains of Alzheimer's disease patients. 
  • Microtubule-driven multimerization recruits ase1p onto overlapping microtubules. 
  • Morphological, biochemical, and genetic support for an apolipoprotein E effect on microtubular metabolism. 
  • MspI RFLP for microtubule associated protein-2 (MAP2). 
  • Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity. 
  • Multiple roles for the active zone protein RIM1alpha in late stages of neurotransmitter release. 
  • Murine Irgm Paralogs Regulate Nonredundant Functions To Execute Host Defense to Toxoplasma gondii. 
  • Mutations in a gene encoding a novel protein containing a phosphotyrosine-binding domain cause type 2 cerebral cavernous malformations. 
  • Mutations in the gene encoding KRIT1, a Krev-1/rap1a binding protein, cause cerebral cavernous malformations (CCM1). 
  • NMDA-glutamate receptors regulate phosphorylation of dendritic cytoskeletal proteins in the hippocampus. 
  • Neurosteroid modulation of embryonic neuronal survival in vitro following anoxia. 
  • Neurotrophic factor-α1 prevents stress-induced depression through enhancement of neurogenesis and is activated by rosiglitazone. 
  • Novel genetic loci associated with hippocampal volume. 
  • NuMA localization, stability, and function in spindle orientation involve 4.1 and Cdk1 interactions. 
  • Pharmacological Inhibition of Lysosomal Activity as a Method For Monitoring Thyroid Hormone-induced Autophagic Flux in Mammalian Cells In Vitro. 
  • Phenotypic characterization of Bbs4 null mice reveals age-dependent penetrance and variable expressivity. 
  • Phosphorylated microtubule associated protein (MAP1B-Phos) in the retina during regeneration of the fish optic nerve. 
  • Phosphorylation of microtubule-associated proteins by protein kinase CK2 in neuritogenesis. 
  • Prenylation-dependent association of Ki-Ras with microtubules. Evidence for a role in subcellular trafficking. 
  • Purinergic receptor X7 is a key modulator of metabolic oxidative stress-mediated autophagy and inflammation in experimental nonalcoholic steatohepatitis. 
  • Quantitative graft integration of fetal hippocampal transplants labeled with 5' bromodeoxyuridine into normal adult hippocampus. 
  • Quantitative measurement of alternatively spliced amyloid precursor protein mRNA expression in Alzheimer's disease and normal brain by S1 nuclease protection analysis. 
  • RPGRIP1s with distinct neuronal localization and biochemical properties associate selectively with RanBP2 in amacrine neurons. 
  • Redirecting Vesicular Transport to Improve Nonviral Delivery of Molecular Cargo. 
  • Refinement of the PARK3 locus on chromosome 2p13 and the analysis of 14 candidate genes. 
  • Regulation of mitochondrial morphology by APC/CCdh1-mediated control of Drp1 stability. 
  • Removal of microglial-specific MyD88 signaling alters dentate gyrus doublecortin and enhances opioid addiction-like behaviors. 
  • Retinal Ganglion Cells With a Glaucoma OPTN(E50K) Mutation Exhibit Neurodegenerative Phenotypes when Derived from Three-Dimensional Retinal Organoids. 
  • Role of Inn1 and its interactions with Hof1 and Cyk3 in promoting cleavage furrow and septum formation in S. cerevisiae. 
  • Role of MAP1B in axonal retrograde transport of mitochondria. 
  • Role of phosphorylated MAPlB in neuritogenesis. 
  • Role of the Hof1-Cyk3 interaction in cleavage-furrow ingression and primary-septum formation during yeast cytokinesis. 
  • Roles for Ndel1 in keratin organization and desmosome function. 
  • SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice. 
  • SUN1 is required for telomere attachment to nuclear envelope and gametogenesis in mice. 
  • SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice. 
  • Spindle function in yeast: a human motor to the rescue. 
  • Survivin DNA vaccine generated specific antitumor effects in pancreatic carcinoma and lymphoma mouse models. 
  • Synapsin I is a microtubule-bundling protein. 
  • TTBK2 controls cilium stability by regulating distinct modules of centrosomal proteins. 
  • Tau protein binding forms a 1 nm thick layer along protofilaments without affecting the radial elasticity of microtubules. 
  • Tau--an inhibitor of deacetylase HDAC6 function. 
  • Temporal regulation of intracellular organelle homeostasis in T lymphocytes by autophagy. 
  • The Drosophila claret segregation protein is a minus-end directed motor molecule. 
  • The E2-like conjugation enzyme Atg3 promotes binding of IRG and Gbp proteins to Chlamydia- and Toxoplasma-containing vacuoles and host resistance. 
  • The G protein-coupled receptor kinase 2 is a microtubule-associated protein kinase that phosphorylates tubulin. 
  • The Meckel syndrome- associated protein MKS1 functionally interacts with components of the BBSome and IFT complexes to mediate ciliary trafficking and hedgehog signaling. 
  • The autophagic protein LC3 translocates to the nucleus and localizes in the nucleolus associated to NUFIP1 in response to cyclic mechanical stress. 
  • The autophagy gene ATG5 plays an essential role in B lymphocyte development. 
  • The carboxyl-terminal amino acids render pro-human LC3B migration similar to lipidated LC3B in SDS-PAGE. 
  • The docking of kinesins, KIF5B and KIF5C, to Ran-binding protein 2 (RanBP2) is mediated via a novel RanBP2 domain. 
  • The exon junction complex component Magoh controls brain size by regulating neural stem cell division. 
  • The exoribonuclease Xrn1 is a post-transcriptional negative regulator of autophagy. 
  • The homotetrameric kinesin-5 KLP61F preferentially crosslinks microtubules into antiparallel orientations. 
  • The indolocarbazole Gö6976 protects neurons from lipopolysaccharide/interferon-gamma-induced cytotoxicity in murine neuron/glia co-cultures. 
  • The kinetics of microtubule assembly. Evidence for a two-stage nucleation mechanism. 
  • The lung is protected from spontaneous inflammation by autophagy in myeloid cells. 
  • The phosphorylated isoform of microtubule associated protein 1B (MAP1B) is expressed in the visual system of the tench (Tinca tinca, L) during optic nerve regeneration. 
  • The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis. 
  • The suppression of testis-brain RNA binding protein and kinesin heavy chain disrupts mRNA sorting in dendrites. 
  • Thyroid Hormone Stimulation of Autophagy Is Essential for Mitochondrial Biogenesis and Activity in Skeletal Muscle. 
  • Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy. 
  • Titin truncations lead to impaired cardiomyocyte autophagy and mitochondrial function in vivo. 
  • Tolfenamic acid enhances pancreatic cancer cell and tumor response to radiation therapy by inhibiting survivin protein expression. 
  • Transcriptional regulation of survivin by c-Myc in BCR/ABL-transformed cells: implications in anti-leukaemic strategy. 
  • Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights. 
  • Transiently expressed ATG16L1 inhibits autophagosome biogenesis and aberrantly targets RAB11-positive recycling endosomes. 
  • Tum/RacGAP50C provides a critical link between anaphase microtubules and the assembly of the contractile ring in Drosophila melanogaster. 
  • VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD. 
  • Variations on the single-molecule assay for microtubule-associated proteins and kinesins 
  • Vascular morphogenesis: tales of two syndromes. 
  • Viral Replication Complexes Are Targeted by LC3-Guided Interferon-Inducible GTPases. 
  • WIPI1 is a conserved mediator of right ventricular failure. 
  • Wsp1 is downstream of Cin1 and regulates vesicle transport and actin cytoskeleton as an effector of Cdc42 and Rac1 in Cryptococcus neoformans. 
  • X-ray crystal structure of the yeast Kar3 motor domain complexed with Mg.ADP to 2.3 A resolution. 
  • XMAP215 is a long thin molecule that does not increase microtubule stiffness. 
  • XRN1 stalling in the 5' UTR of Hepatitis C virus and Bovine Viral Diarrhea virus is associated with dysregulated host mRNA stability. 
  • Yeast Kar3 is a minus-end microtubule motor protein that destabilizes microtubules preferentially at the minus ends. 
  • p27 and cyclin D1 abnormalities in uterine papillary serous carcinoma. 
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  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Ciofani, Maria, Associate Professor of Integrative Immunobiology, Cell Biology
  • Lee, Walter T, Professor of Head and Neck Surgery & Communication Sciences, Radiation Oncology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Schwartz-Bloom, Rochelle D., Professor Emeritus of Pharmacology & Cancer Biology, Duke Science & Society
  • Taylor, Gregory Alan, Professor in Medicine, Integrative Immunobiology