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Subject Areas on Research
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3-nitrotyrosine attenuates respiratory syncytial virus infection in human bronchial epithelial cell line.
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A Mec17-Myosin II Effector Axis Coordinates Microtubule Acetylation and Actin Dynamics to Control Primary Cilium Biogenesis.
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A PIK3C3-ankyrin-B-dynactin pathway promotes axonal growth and multiorganelle transport.
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A bidirectional kinesin motor in live Drosophila embryos.
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A cellular genome-wide association study reveals human variation in microtubule stability and a role in inflammatory cell death.
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A chimeric kinesin-1 head/kinesin-5 tail motor switches between diffusive and processive motility.
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A comprehensive model to predict mitotic division in budding yeasts.
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A kinesin motor in a force-producing conformation.
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A microtubule-destabilizing kinesin motor regulates spindle length and anchoring in oocytes.
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A model for fast axonal transport.
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A mutant of the motor protein kinesin that moves in both directions on microtubules.
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A new identity for MLK3 as an NIMA-related, cell cycle-regulated kinase that is localized near centrosomes and influences microtubule organization.
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A point mutation in the microtubule binding region of the Ncd motor protein reduces motor velocity.
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A specific domain of Gialpha required for the transactivation of Gialpha by tubulin is implicated in the organization of cellular microtubules.
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A structural pathway for activation of the kinesin motor ATPase.
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A systematic analysis of microtubule-destabilizing factors during dendrite pruning in Drosophila.
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A transgenic toolkit for visualizing and perturbing microtubules reveals unexpected functions in the epidermis.
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ANK2 autism mutation targeting giant ankyrin-B promotes axon branching and ectopic connectivity.
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Active cellular materials.
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Allosteric inhibition of kinesin-5 modulates its processive directional motility.
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Altered nucleotide-microtubule coupling and increased mechanical output by a kinesin mutant.
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An N-terminal truncation of the ncd motor protein supports diffusional movement of microtubules in motility assays.
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An ankyrin-based mechanism for functional organization of dystrophin and dystroglycan.
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An estimate to the first approximation of microtubule rupture force.
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Analysis of the regulation of microtubule dynamics by interaction of RGSZ1 (RGS20) with the neuronal stathmin, SCG10.
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Anastral spindle assembly: a mathematical model.
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Ankyrin-B interactions with spectrin and dynactin-4 are required for dystrophin-based protection of skeletal muscle from exercise injury.
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Ankyrin-G is a molecular partner of E-cadherin in epithelial cells and early embryos.
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Apparent elastic modulus and hysteresis of skeletal muscle cells throughout differentiation.
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Are cross-bridging structures involved in the bundle formation of intermediate filaments and the decrease in locomotion that accompany cell aging?
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Arl2- and Msps-dependent microtubule growth governs asymmetric division.
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Arrestin translocation is induced at a critical threshold of visual signaling and is superstoichiometric to bleached rhodopsin.
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Assays to measure plasma membrane and cytoskeletal changes in interferon-treated cells.
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Assembly and dynamics of an anastral:astral spindle: the meiosis II spindle of Drosophila oocytes.
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Assembly of microtubules from preformed, ring-shaped protofilaments and 6-S tubulin.
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Assembly pathway of the anastral Drosophila oocyte meiosis I spindle.
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Association of ebola virus matrix protein VP40 with microtubules.
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Bacterial cell division protein FtsZ assembles into protofilament sheets and minirings, structural homologs of tubulin polymers.
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Beyond taxanes: a review of novel agents that target mitotic tubulin and microtubules, kinases, and kinesins.
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Bidirectional power stroke by ncd kinesin.
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Binding sites on microtubules of kinesin motors of the same or opposite polarity.
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Biochemistry. Friction in motor proteins.
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Broken Detailed Balance of Filament Dynamics in Active Networks.
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Calcium-dependent regulator protein: localization in mitotic apparatus of eukaryotic cells.
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Calmodulin as a mediator of hormone action and cell regulation.
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Calmodulin in endocrine cells and its multiple roles in hormone action.
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Calmodulin, cell growth and gene expression.
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Calmodulin--an intracellular calcium receptor.
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Calmodulin-microtubule association in cultured mammalian cells.
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Calmodulin: properties, intracellular localization, and multiple roles in cell regulation.
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Cell division requires a direct link between microtubule-bound RacGAP and Anillin in the contractile ring.
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Cell polarity in sea urchin embryos: reorientation of cells occurs quickly in aggregates.
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Cell-cycle checkpoints that ensure coordination between nuclear and cytoplasmic events in Saccharomyces cerevisiae.
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Characterization of adipose-derived mesenchymal stem cell combinations for vascularized bone engineering.
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Characterization of microtubule-associated protein MAP1B: phosphorylation state, light chains, and binding to microtubules.
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Checkpoint signals in grasshopper meiosis are sensitive to microtubule attachment, but tension is still essential.
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Cleavage-furrow formation without F-actin in Chlamydomonas
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Conditional root expansion mutants of Arabidopsis.
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Control of microtubule assembly-disassembly by calcium-dependent regulator protein.
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Coordinating cytoskeletal tracks to polarize cellular movements.
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Current Progress in Electrotransfection as a Nonviral Method for Gene Delivery.
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Cyclic adenosine 3',5' monophosphate, calcium and protein phosphorylation in flagellar motility.
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Cytoplasmic dynein is required to oppose the force that moves nuclei towards the hyphal tip in the filamentous ascomycete Ashbya gossypii.
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DEPDC1/LET-99 participates in an evolutionarily conserved pathway for anti-tubulin drug-induced apoptosis.
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Decoupling of nucleotide- and microtubule-binding sites in a kinesin mutant.
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Definition of distinct compartments in polarized Madin-Darby canine kidney (MDCK) cells for membrane-volume sorting, polarized sorting and apical recycling.
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Deformation and collapse of microtubules on the nanometer scale.
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Deletion of the Tail Domain of the Kinesin-5 Cin8 Affects Its Directionality.
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Depletion of casein kinase II by antisense oligonucleotide prevents neuritogenesis in neuroblastoma cells.
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Desmoplakin: an unexpected regulator of microtubule organization in the epidermis.
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Determinants of kinesin motor polarity.
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Determinants of molecular motor directionality.
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Diatom gliding is the result of an actin-myosin motility system.
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Differential regulation of polarized synaptic vesicle trafficking and synapse stability in neural circuit rewiring in Caenorhabditis elegans.
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Differential uptake of DNA–poly (ethylenimine) polyplexes in cells cultured on collagen and fibronectin surfaces
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Dilution-induced disassembly of microtubules: relation to dynamic instability and the GTP cap.
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Direct interaction of Gas11 with microtubules: implications for the dynein regulatory complex.
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Direct observation of kinesin stepping by optical trapping interferometry.
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Direct ultrastructural evidence of target-directed polarization by cytotoxic lymphocytes in lesions of human graft-vs-host disease.
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Directionality and processivity of molecular motors.
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Directionality of individual kinesin-5 Cin8 motors is modulated by loop 8, ionic strength and microtubule geometry.
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Divergent regulation of functionally distinct γ-tubulin complexes during differentiation.
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Doublecortin-Like Kinases Promote Neuronal Survival and Induce Growth Cone Reformation via Distinct Mechanisms.
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Drosophila spastin regulates synaptic microtubule networks and is required for normal motor function.
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Dynamic instability of individual microtubules analyzed by video light microscopy: rate constants and transition frequencies.
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Dynamic microtubules drive circuit rewiring in the absence of neurite remodeling.
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Dynamic positioning of mitotic spindles in yeast: role of microtubule motors and cortical determinants.
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Dynamin and FtsZ. Missing links in mitochondrial and bacterial division.
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Dysferlin, annexin A1, and mitsugumin 53 are upregulated in muscular dystrophy and localize to longitudinal tubules of the T-system with stretch.
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EB1-microtubule interactions in Xenopus egg extracts: role of EB1 in microtubule stabilization and mechanisms of targeting to microtubules.
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Effect of vanadate on intracellular distribution and function of 10-nm filaments.
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Effect of vinblastine on neurohypophysial and adenohypophysial microtubules.
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Effect of vinblastine on rat liver ultrastructure.
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Effect of vinblastine on the fine structure of the rat adrenal cortex.
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Effect of vitamin A on microtubules of rat brain and liver.
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Effects of colchicine and cytochalasin B on vasopressin- and cyclic adenosine monophosphate-induced changes in toad urinary bladder.
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Effects of downregulated HDAC6 expression on the proliferation of lung cancer cells.
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Effects of magnesium on the dynamic instability of individual microtubules.
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Effects of taxol and Colcemid on myofibrillogenesis.
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Effects of the src gene product on microfilament and microtubule organization in avian and mammalian cells infected with the same temperature-sensitive mutant of Rous sarcoma virus.
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Elastic response, buckling, and instability of microtubules under radial indentation.
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Electron microscopy of MAP 2 (microtubule-associated protein 2).
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Enhancement of the ncdD microtubule motor mutant by mutants of alpha Tub67C.
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Erythrocyte ankyrin: immunoreactive analogues are associated with mitotic structures in cultured cells and with microtubules in brain.
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Evaluation of new anticancer agents against human pancreatic carcinomas in nude mice.
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Evolution in action: giant ankyrins awake.
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Expanded polyglutamine stretches form an 'aggresome'.
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Exploring the mechanism of Physcomitrella patens desiccation tolerance through a proteomic strategy.
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Expression of microtubule motor proteins in bacteria for characterization in in vitro motility assays.
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FSH stimulation of protein kinase inhibitor: regulation of cellular metabolism.
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Fetal rat amniotic fluid: transforming growth factor beta and fibroblast collagen lattice contraction.
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Fibrillar systems in cell motility.
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Fluorescence recovery kinetic analysis of gamma-tubulin binding to the mitotic spindle.
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Function of microtubules under inadequate protein diet.
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Functions of cytoplasmic fibers in intracellular movements in BHK-21 cells.
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GTP hydrolysis during microtubule assembly.
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Gamma-tubulin nucleation: template or protofilament?
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Genetically induced microtubule disruption in the mouse intestine impairs intracellular organization and transport.
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Guanosinetriphosphatase activity of tubulin associated with microtubule assembly.
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HDAC6 is a microtubule-associated deacetylase.
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High-resolution mapping of intracellular fluctuations using carbon nanotubes.
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Highly processive motility is not a general feature of the kinesins.
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Histone deacetylase 6 regulates growth factor-induced actin remodeling and endocytosis.
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How calcium causes microtubule depolymerization.
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How cells get the right chromosomes.
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How the kinetochore couples microtubule force and centromere stretch to move chromosomes.
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Human apolipoprotein E accelerates microtubule polymerization in vitro.
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Hypothesis: microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype.
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Imaging microtubules and kinesin decorated microtubules using tapping mode atomic force microscopy in fluids.
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Immunoreactive forms of erythrocyte spectrin and ankyrin in brain.
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Immunoreactive forms of human erythrocyte ankyrin are localized in mitotic structures in cultured cells and are associated with microtubules in brain.
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In situ imaging in C. elegans reveals developmental regulation of microtubule dynamics.
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In vitro motility of AtKCBP, a calmodulin-binding kinesin protein of Arabidopsis.
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In vivo proximity proteomics of nascent synapses reveals a novel regulator of cytoskeleton-mediated synaptic maturation.
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Increased calmodulin affects cell morphology and mRNA levels of cytoskeletal protein genes.
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Increased organization of cytoskeleton accompanying the aging of human fibroblasts in vitro.
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Influence of cytoskeletal assembly on phosphatidylcholine synthesis in intact phagocytic cells.
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Inhibition of Spleen Tyrosine Kinase Potentiates Paclitaxel-Induced Cytotoxicity in Ovarian Cancer Cells by Stabilizing Microtubules.
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Interferon suppresses pinocytosis but stimulates phagocytosis in mouse peritoneal macrophages: related changes in cytoskeletal organization.
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Involvement of microtubules and 10-nm filaments in the movement and positioning of nuclei in syncytia.
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KIF18B is a cell type-specific regulator of spindle orientation in the epidermis.
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Kar3 interaction with Cik1 alters motor structure and function.
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Katanin p60-like1 promotes microtubule growth and terminal dendrite stability in the larval class IV sensory neurons of Drosophila.
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Kinesin proteins: a phylum of motors for microtubule-based motility.
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Kinesin walks the line: single motors observed by atomic force microscopy.
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Kinesin-5 Kip1 is a bi-directional motor that stabilizes microtubules and tracks their plus-ends in vivo.
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Large conformational changes in a kinesin motor catalyzed by interaction with microtubules.
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Lipid-based microtubular drug delivery vehicles.
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Lis1 is essential for cortical microtubule organization and desmosome stability in the epidermis.
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Load-dependent release limits the processive stepping of the tetrameric Eg5 motor.
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Mammalian septins regulate microtubule stability through interaction with the microtubule-binding protein MAP4.
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Mature Drosophila meiosis I spindles comprise microtubules of mixed polarity.
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Mediation of meiotic and early mitotic chromosome segregation in Drosophila by a protein related to kinesin.
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Meiosis, mitosis and microtubule motors.
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Messenger ribonucleoprotein complexes containing human ELAV proteins: interactions with cytoskeleton and translational apparatus.
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Microtubule Assembly from Single Flared Protofilaments-Forget the Cozy Corner?
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Microtubule acetylation amplifies p38 kinase signalling and anti-inflammatory IL-10 production.
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Microtubule cross-linking triggers the directional motility of kinesin-5.
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Microtubule disruption leads to cellular contraction in human trabecular meshwork cells.
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Microtubule dynamic instability and GTP hydrolysis.
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Microtubule nucleation and organization in teleost photoreceptors: microtubule recovery after elimination by cold.
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Microtubule organization, dynamics and functions in differentiated cells.
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Microtubule organization: cell shape is destiny.
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Microtubule stabilization and potentiation of taxol activity by the creatine analog cyclocreatine.
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Microtubule structure at 18 A resolution.
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Microtubule surface lattice and subunit structure and observations on reassembly.
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Microtubule treadmilling in vitro investigated by fluorescence speckle and confocal microscopy.
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Microtubule-driven multimerization recruits ase1p onto overlapping microtubules.
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Microtubules accelerate the kinase activity of Aurora-B by a reduction in dimensionality.
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Mitochondria-enriched protrusions are associated with brain and intestinal stem cells in Drosophila.
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Molecular and cellular mechanisms of leukocyte chemotaxis.
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Morphological, biochemical, and genetic support for an apolipoprotein E effect on microtubular metabolism.
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Motor proteins 1: kinesins.
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Mutants of the microtubule motor protein, nonclaret disjunctional, affect spindle structure and chromosome movement in meiosis and mitosis.
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Neck-linker length dependence of processive Kinesin-5 motility.
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Neck-motor interactions trigger rotation of the kinesin stalk.
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Noncentrosomal microtubules and type II myosins potentiate epidermal cell adhesion and barrier formation.
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Normal spastin gene dosage is specifically required for axon regeneration.
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Not just another hole in the wall: understanding intercellular protein trafficking.
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Novel chemotherapies in development for management of castration-resistant prostate cancer.
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NuMA-microtubule interactions are critical for spindle orientation and the morphogenesis of diverse epidermal structures.
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Nucleation of microtubule assembly. Experimental kinetics, computer fitting of models, and observations on tubulin rings.
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Phorbol myristate acetate stimulates microtubule and 10-nm filament extension and lysosome redistribution in mouse macrophages.
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Physiological implications of the presence, distribution, and regulation of calmodulin in eukaryotic cells.
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Plasmids for expression of chimeric and truncated kinesin proteins.
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Polycation-induced assembly of purified tubulin.
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Posttranslational modifications of tubulin in teleost photoreceptor cytoskeletons.
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Prenylation-dependent association of Ki-Ras with microtubules. Evidence for a role in subcellular trafficking.
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Protein inhibitor of cAMP-dependent protein kinase: production and characterization of antibodies and intracellular localization.
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Protein tracking and detection of protein motion using atomic force microscopy.
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Protofilaments and rings, two conformations of the tubulin family conserved from bacterial FtsZ to alpha/beta and gamma tubulin.
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RANBP2 is an allosteric activator of the conventional kinesin-1 motor protein, KIF5B, in a minimal cell-free system.
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Radial migration: Retinal neurons hold on for the ride.
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Rapid double 8-nm steps by a kinesin mutant.
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Rapid in vitro assembly dynamics and subunit turnover of FtsZ demonstrated by fluorescence resonance energy transfer.
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Rapid purification of microtubule motor domain proteins expressed in bacteria.
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Rapid up-regulation of peptide elongation factor EF-1alpha protein levels is an immediate early event during oxidative stress-induced apoptosis.
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Regulation by and of calmodulin in mammalian cells.
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Regulation of microfilaments and microtubules by calcium and cyclic AMP.
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Regulation of the cytoskeleton by Ca2+-calmodulin and cAMP.
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Regulation of the postsynaptic cytoskeleton: roles in development, plasticity, and disorders.
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Regulation of the testis sertoli cell by follicle stimulating hormone.
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Relationship between movement and aggregation of centrioles in syncytia and formation of microtubule bundles.
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Resolving the molecular structure of microtubules under physiological conditions with scanning force microscopy.
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Roles for microtubules in the proliferative and differentiated cells of stratified epithelia.
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Self-Organized Nuclear Positioning Synchronizes the Cell Cycle in Drosophila Embryos.
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Serum retinol binding protein secretion through microtubules in chicks.
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Spatiotemporal dynamics of GEF-H1 activation controlled by microtubule- and Src-mediated pathways.
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Src-mediated tyrosine phosphorylation of dynamin is required for beta2-adrenergic receptor internalization and mitogen-activated protein kinase signaling.
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Stabilizing electrode-host interfaces: a tissue engineering approach.
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Structural and functional domains of the Drosophila ncd microtubule motor protein.
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Structure and function of the visual arrestin oligomer.
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Structure of microtubules with reduced hydration. Comparison of results from X-ray diffraction and electron microscopy.
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Studies on the in vivo sensitivity of spindle microtubules to calcium ions and evidence for a vesicular calcium-sequestering system.
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Subcellular changes in capillary endothelial cells during repair of hyperoxic lung injury.
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Subcellular localization of spastin: implications for the pathogenesis of hereditary spastic paraplegia.
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Sulfo-SMCC Prevents Annealing of Taxol-Stabilized Microtubules In Vitro.
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Super-Resolution Optical Fluctuation Bio-Imaging with Dual-Color Carbon Nanodots.
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Sustained release of BMP-2 in a lipid-based microtube vehicle.
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T-tubule depolarization-induced SR Ca2+ release is controlled by dihydropyridine receptor- and Ca(2+)-dependent mechanisms in cell homogenates from rabbit skeletal muscle.
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Tau is essential to beta -amyloid-induced neurotoxicity.
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Tau protein binding forms a 1 nm thick layer along protofilaments without affecting the radial elasticity of microtubules.
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Tension on chromosomes increases the number of kinetochore microtubules but only within limits.
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The C-terminal polylysine region and methylation of K-Ras are critical for the interaction between K-Ras and microtubules.
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The Drosophila claret segregation protein is a minus-end directed motor molecule.
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The Drosophila ncd microtubule motor protein is spindle-associated in meiotic and mitotic cells.
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The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks.
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The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress.
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The discovery of the prokaryotic cytoskeleton: 25th anniversary.
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The effect of halothane on cultured fibroblasts and neuroblastoma cells.
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The effect of monastrol on the processive motility of a dimeric kinesin-5 head/kinesin-1 stalk chimera.
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The homotetrameric kinesin-5 KLP61F preferentially crosslinks microtubules into antiparallel orientations.
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The interaction of RGSZ1 with SCG10 attenuates the ability of SCG10 to promote microtubule disassembly.
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The kinetics of microtubule assembly. Evidence for a two-stage nucleation mechanism.
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The marriage of quantitative genetics and cell biology: a novel screening approach reveals people have genetically encoded variation in microtubule stability.
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The microtubule interacting drug candidate NAP protects against kainic acid toxicity in a rat model of epilepsy.
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The microtubule-associated histone deacetylase 6 (HDAC6) regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation.
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The minus end-directed motor Kar3 is required for coupling dynamic microtubule plus ends to the cortical shmoo tip in budding yeast.
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The natural diterpene tonantzitlolone A and its synthetic enantiomer inhibit cell proliferation and kinesin-5 function.
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The prevalence of abnormal cilia in normal pediatric lungs.
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The role of actin in spindle orientation changes during the Saccharomyces cerevisiae cell cycle.
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The role of subunit entropy in cooperative assembly. Nucleation of microtubules and other two-dimensional polymers.
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The role of the cytoskeleton in aging.
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The structure and assembly of microtubules.
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The synergistic combination of the farnesyl transferase inhibitor lonafarnib and paclitaxel enhances tubulin acetylation and requires a functional tubulin deacetylase.
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The tail domain of the Aspergillus fumigatus class V myosin MyoE orchestrates septal localization and hyphal growth.
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The use of lipid microtubes as a novel slow-release delivery system for laryngeal injection.
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Thermodynamic and kinetic aspects of assembly.
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To excite a heart: a bird's view.
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Tubular arrays on electron microscopy not specific.
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Tubulin and calmodulin. Effects of microtubule and microfilament inhibitors on localization in the mitotic apparatus.
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Tubulin rings: curved filaments with limited flexibility and two modes of association.
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Tum/RacGAP50C provides a critical link between anaphase microtubules and the assembly of the contractile ring in Drosophila melanogaster.
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Two Small Molecules Block Oral Epithelial Cell Invasion by Porphyromons gingivalis.
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Two new loci, PLEIADE and HYADE, implicate organ-specific regulation of cytokinesis in Arabidopsis.
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Two-dimensional tracking of ncd motility by back focal plane interferometry.
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Two-state displacement by the kinesin-14 Ncd stalk.
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Ultrastructure of heart muscle.
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Visualizing Intracellular Organelle and Cytoskeletal Interactions at Nanoscale Resolution on Millisecond Timescales.
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Working strokes by single molecules of the kinesin-related microtubule motor ncd.
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XMAP215 is a long thin molecule that does not increase microtubule stiffness.
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Yeast Kar3 is a minus-end microtubule motor protein that destabilizes microtubules preferentially at the minus ends.
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Keywords of People