Models, Structural

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  Subject Areas on Research

  • "Harvey," the cardiology patient simulator: pilot studies on teaching effectiveness. 
  • A cardiac phantom and pulsatile flow pump for magnetic resonance imaging studies. 
  • A comparison of stone damage caused by different modes of shock wave generation. 
  • A cone beam SPECT reconstruction algorithm with a displaced center of rotation. 
  • A cyclin A-protein kinase complex possesses sequence-specific DNA binding activity: p33cdk2 is a component of the E2F-cyclin A complex. 
  • A filtered backprojection algorithm for pinhole SPECT with a displaced centre of rotation. 
  • A high resolution structure of an inhibitor complex of the extracellular nuclease of Staphylococcus aureus. I. Experimental procedures and chain tracing. 
  • A mammalian protein of 220 kDa binds pre-mRNAs in the spliceosome: a potential homologue of the yeast PRP8 protein. 
  • A new composite model of objects for Monte Carlo simulation of radiological imaging. 
  • A phantom for testing ECG-gated computed tomography of the heart. 
  • A technique of automating compensator design for lung inhomogeneity correction using an electron portal imaging device. 
  • Accuracy of registration of PET, SPECT and MR images of a brain phantom. 
  • Accuracy of ultrasound in fetal femur length determination. Ultrasound phantom study. 
  • Adducin: a physical model with implications for function in assembly of spectrin-actin complexes. 
  • Aerosol characteristics of 99mTc-pentetic acid (DTPA) and synthetic surfactant (Exosurf). 
  • An artificial neural network approach to quantitative single photon emission computed tomographic reconstruction with collimator, attenuation, and scatter compensation. 
  • An artificial neural network for lesion detection on single-photon emission computed tomographic images. 
  • An evaluation of lesion detectability with cone-beam, fanbeam and parallel-beam collimation in SPECT by continuous ROC study. 
  • Ankyrin and synapsin: spectrin-binding proteins associated with brain membranes. 
  • Application of quantitative coronary angiography in a cineless environment: in vivo assessment of a fully automated system for clinical use. 
  • Bayesian restoration of chest radiographs. Scatter compensation with improved signal-to-noise ratio. 
  • Brain fluoxetine measurements using fluorine magnetic resonance spectroscopy in patients with social phobia. 
  • Brain phantom: high-resolution imaging with SPECT and I-123. 
  • Calorimetric analysis of the binding of lectins with overlapping carbohydrate-binding ligand specificities. 
  • Cardiac ejection fraction: phantom study comparing cine MR imaging, radionuclide blood pool imaging, and ventriculography. 
  • Cardiac phantom evaluation of simultaneously acquired dual-isotope rest thallium-201/stress technetium-99m SPECT images. 
  • Cardiac ultrasound phantom using a porcine heart model. 
  • Characterization of kinectin, a kinesin-binding protein: primary sequence and N-terminal topogenic signal analysis. 
  • Characterization of the transmembrane orientation of aquaporin-1 using antibodies to recombinant fusion proteins. 
  • Cine phase-contrast magnetic resonance imaging for analysis of flow phenomena in experimental aortic dissection. 
  • Combining pressure-limiting and volume-cycling features in a patient-interactive mechanical breath. 
  • Comparison of 180 degrees and 360 degrees data collection in thallium-20 1 imaging using single-photon emission computerized tomography (SPECT): concise communication. 
  • Comparison of ultrasonography and oral cholecystography in lithotripsy. II. Determining retreatment. 
  • Computed tomographic evaluation of surgical clip artifact: tissue phantom and experimental animal assessment. 
  • Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation. 
  • Construction of a catalytically active iron superoxide dismutase by rational protein design. 
  • Controlled eddy currents: applications to MR imaging. 
  • Correction of spatially dependent phase shifts for partial Fourier imaging. 
  • Crossbridges in the complete unit cell of rigor insect flight muscle imaged by three-dimensional reconstruction from oblique sections. 
  • D2 dopamine receptors in the human retina: cloning of cDNA and localization of mRNA. 
  • Deconvolution of Compton scatter in SPECT. 
  • Differences in hydrocarbon chain tilt between hydrated phosphatidylethanolamine and phosphatidylcholine bilayers. A molecular packing model. 
  • Diffusion-weighted MR microscopy with fast spin-echo. 
  • Digital beam attenuator technique for compensated chest radiography. 
  • Digital chest radiography with storage phosphor systems: potential masking of bilateral pleural effusions. 
  • Direct cone beam SPECT reconstruction with camera tilt. 
  • Discrete amino acid sequences of the alpha 1-adrenergic receptor determine the selectivity of coupling to phosphatidylinositol hydrolysis. 
  • Disproportionate effects of regional hypokinesis on radionuclide ejection fraction: compensation using attenuation-corrected ventricular volumes. 
  • Disruption of a topoisomerase-DNA cleavage complex by a DNA helicase. 
  • Effect of cytoskeletal geometry on intracellular diffusion. 
  • Esophageal source measurement of Tc-99m attenuation coefficients for use in left ventricular volume determinations. 
  • Estimation of the mean caliper diameter of cell nuclei. I. Serial section reconstriction method and endothelial nuclei from human lung. 
  • Evaluation of edge-induced streaking artifacts in CT scanners. 
  • Evaluation of flow through simulated vascular stenoses with gradient echo magnetic resonance imaging. 
  • Evaluation of steady and pulsatile flow with dynamic MRI using limited flip angles and gradient refocused echoes. 
  • Fast transmission CT for determining attenuation maps using a collimated line source, rotatable air-copper-lead attenuators and fan-beam collimation. 
  • Feasibility study for a two-dimensional diagnostic ultrasound velocity mapping system. 
  • Film-based chest radiography: AMBER vs asymmetric screen-film systems. 
  • Flow permeation analysis of bovine cervical mucus. 
  • G protein-coupled receptor kinases. 
  • Handedness of crossover connections in beta sheets. 
  • Heating patterns generated by phase modulation of a hexagonal array of interstitial antennas. 
  • High kVp vs. low kVp for T-tube and operative cholangiography. 
  • High-dose areas are unintentionally created as a result of gap shifts when the prescribed dose in the two adjacent areas are different. 
  • High-field MR microscopy using fast spin-echoes. 
  • High-resolution multiplanar CT images of the larynx. 
  • Human centromere structure: organization and potential role of alpha satellite DNA. 
  • Identification of amino acid residues involved in structural and ubiquinone-binding functions of subunit IV of the cytochrome bc1 complex from Rhodobacter sphaeroides. 
  • Identification of functional regions on the tail of Acanthamoeba myosin-II using recombinant fusion proteins. I. High resolution epitope mapping and characterization of monoclonal antibody binding sites. 
  • Image reconstruction using electron micrographs of insect flight muscle. Use of thick transverse sections to supplement data from tilted thin longitudinal sections. 
  • Image techniques for multiplanar computed tomography. 
  • Immunoglobulin-like PapD chaperone caps and uncaps interactive surfaces of nascently translocated pilus subunits. 
  • Improved cardiac anthropomorphic phantom. 
  • In situ magnetic resonance microscopy. 
  • In vitro analysis of stone fragmentation ability of the FREDDY laser. 
  • In vitro comparison of fragmentation efficiency of flexible pneumatic lithotripsy using 2 flexible ureteroscopes. 
  • In vitro comparison of standard ultrasound and pneumatic lithotrites with a new combination intracorporeal lithotripsy device. 
  • In vitro evaluation of volumetric flow from Doppler power-weighted and amplitude-weighted mean velocities. 
  • Inhibition of G protein-coupled receptor signaling by expression of cytoplasmic domains of the receptor. 
  • Integrated MR imaging and spectroscopy with chemical shift imaging of P-31 at 1.5 T: initial clinical experience. 
  • Interstitial microwave hyperthermia in a canine brain model. 
  • Interstitial microwave-induced hyperthermia and iridium brachytherapy for the treatment of obstructing biliary carcinomas. 
  • Inverse Monte Carlo as a unified reconstruction algorithm for ECT. 
  • Lesion detection with single-photon emission computed tomography (SPECT) compared with conventional imaging. 
  • Lesion size quantification in SPECT using an artificial neural network classification approach. 
  • MR imaging of microcirculation in rat brain: correlation with carbon dioxide-induced changes in blood flow. 
  • MR imaging of venous and arterial flow by a selective saturation-recovery spin echo (SSRSE) method. 
  • Magnetic resonance imaging of blood flow with a phase subtraction technique. In vitro and in vivo validation. 
  • Magnetic resonance imaging--cardiac ejection fraction measurements. Phantom study comparing four different methods. 
  • Magnetization-prepared MR angiography with fat suppression and venous saturation. 
  • Mammalian C-type oncornaviruses: relationships between viral structural and cell-surface antigens and their possible significance in immunological defense mechanisms. 
  • Maximization of contrast-to-noise ratio to distinguish diffusion and microcirculatory flow. 
  • Maximizing contrast to noise with inductively coupled implanted coils. 
  • Measurement of the elastic modulus for red cell membrane using a fluid mechanical technique. 
  • Mechanisms of beta-adrenergic receptor desensitization and resensitization. 
  • Model of alpha 2-macroglobulin structure and function. 
  • Modelling aperture antennas in the near- and far-field regions using subarrays of equivalent uniformly illuminated apertures. 
  • Modifications of the cardiac double-layer source arising from interstitial potentials. 
  • Molecular endpoints of Ca2+/calmodulin- and voltage-dependent inactivation of Ca(v)1.3 channels. 
  • Movable core guide wire: evaluation of improved model. 
  • Multiple and specific initiation of T4 DNA replication. 
  • Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects. 
  • Noise characteristics for cone beam collimators: a comparison with parallel hole collimator. 
  • Non-invasive thermometry using magnetic resonance diffusion imaging: potential for application in hyperthermic oncology. 
  • Nonisotropic attenuation in SPECT: phantom tests of quantitative effects and compensation techniques. 
  • Oblique section 3-D reconstruction of relaxed insect flight muscle reveals the cross-bridge lattice in helical registration. 
  • Observations on the use of ferromagnetic implants for inducing hyperthermia. 
  • On the accuracy of noninvasive thermometry using molecular diffusion magnetic resonance imaging. 
  • Opposite orientations of DNA bending by c-Myc and Max. 
  • Performance characteristics of a whole-body PET scanner. 
  • Phantom depth dose distributions from Panorex dental x-rays. 
  • Pitfalls in the determination of absolute dimensions using angiographic catheters as calibration devices in quantitative angiography. 
  • Posterior beam-stop method for scatter fraction measurement in digital radiography. 
  • Poststenotic signal loss in MR angiography: effects of echo time, flow compensation, and fractional echo. 
  • Pulsed Doppler spectral analysis of bounded fluid jets. 
  • Purification of a 12,020-dalton protein that enhances the activation of mitogen-activated protein (MAP) kinase by MAP kinase kinase. 
  • Quantitative SPECT reconstruction of iodine-123 data. 
  • Quantitative scatter measurement in digital radiography using a photostimulable phosphor imaging system. 
  • Range and magnitude of the steric pressure between bilayers containing phospholipids with covalently attached poly(ethylene glycol). 
  • Rapid MR imaging of blood flow with a phase-sensitive, limited-flip-angle, gradient recalled pulse sequence: preliminary experience. 
  • Real space refinement of acto-myosin structures from sectioned muscle. 
  • Reduction of ringing and blurring artifacts in fast spin-echo imaging. 
  • Reproducibility of relaxation and spin-density parameters in phantoms and the human brain measured by MR imaging at 1.5 T. 
  • Respiratory function during pressure support ventilation. 
  • Reversible unfolding of fibronectin type III and immunoglobulin domains provides the structural basis for stretch and elasticity of titin and fibronectin. 
  • SPECT using a specially designed cone beam collimator. 
  • Scatter compensation for digital chest radiography using maximum likelihood expectation maximization. 
  • Secondary structure of a leucine zipper determined by nuclear magnetic resonance spectroscopy. 
  • Separation of limited tryptic fragments of human ceruloplasmin by gel-permeation high-performance liquid chromatography. 
  • Shock wave physics. 
  • Simultaneous compensation for attenuation, scatter and detector response for SPECT reconstruction in three dimensions. 
  • Small object contrast in AMBER and conventional chest radiography. 
  • Structural basis for specificity of Grb2-SH2 revealed by a novel ligand binding mode. 
  • Structural conservation of ion conduction pathways in K channels and glutamate receptors. 
  • Structural organization of the human insulin receptor ectodomain. 
  • Structure and phase behavior of lipid suspensions containing phospholipids with covalently attached poly(ethylene glycol). 
  • Structure-function relationships of the alternative oxidase of plant mitochondria: a model of the active site. 
  • Surface friction in near-vertex head and neck impact increases risk of injury. 
  • Tc-99m attenuation coefficients in water-filled phantoms determined with gamma cameras. 
  • Teaching bedside cardiologic examination skills using "Harvey", the cardiology patient simulator. 
  • The ANK repeats of erythrocyte ankyrin form two distinct but cooperative binding sites for the erythrocyte anion exchanger. 
  • The Maltese cross processor: speckle reduction for circular transducers. 
  • The angiotensin II type I receptor-associated protein, ATRAP, is a transmembrane protein and a modulator of angiotensin II signaling. 
  • The effect of hypothermia on calculated values using saline and automated air tonometry. 
  • The kinetics of microtubule assembly. Evidence for a two-stage nucleation mechanism. 
  • The relationship between the mitochondrial gene T-urf13 and fungal pathotoxin sensitivity in maize. 
  • The simple construction of protein alpha-carbon models. 
  • The site of the redox-linked proton pump in eukaryotic cytochrome c oxidases. 
  • The structure and assembly of microtubules. 
  • The use of gradient flow compensation to separate diffusion and microcirculatory flow in MRI. 
  • Theoretical simulation of oxygen transport to tumors by three-dimensional networks of microvessels. 
  • Thermal distribution studies of helical coil microwave antennas for interstitial hyperthermia. 
  • Three-dimensional SPECT reconstruction of combined cone beam and parallel beam data. 
  • Three-dimensional image reconstruction of insect flight muscle. I. The rigor myac layer. 
  • Three-dimensional image reconstruction of insect flight muscle. II. The rigor actin layer. 
  • Three-dimensional membrane crystals in amphibian cone outer segments. 1. Light-dependent crystal formation in frog retinas. 
  • Three-dimensional photon detection kernels and their application to SPECT reconstruction. 
  • Threshold perception performance with computed and screen-film radiography: implications for chest radiography. 
  • Transient cavitation and acoustic emission produced by different laser lithotripters. 
  • Treatment of Compton scattering in maximum-likelihood, expectation-maximization reconstructions of SPECT images. 
  • Truncation artifact reduction in transmission CT for improved SPECT attenuation compensation. 
  • URF13, a ligand-gated, pore-forming receptor for T-toxin in the inner membrane of cms-T mitochondria. 
  • URF13, a maize mitochondrial pore-forming protein, is oligomeric and has a mixed orientation in Escherichia coli plasma membranes. 
  • Unusual structure of the human immunodeficiency virus type 1 trans-activation response element. 
  • Variable compensation technique for digital radiography of the chest. 
  • Verification of a hyperthermia model method using MR thermometry. 
  • Volume and activity quantitation with iodine-123 SPECT. 
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  Keywords of People

  • Erickson, Harold Paul, James B. Duke Professor of Cell Biology, Biomedical Engineering
  • Lo, Joseph Yuan-Chieh, Professor of Radiology, Electrical and Computer Engineering
  • MacFall, James R., Adjunct Professor in the Department of Radiology, Radiology
  • Nightingale, Roger W, Adjunct Associate Professor of Biomedical Engineering, Biomedical Engineering
  • Preminger, Glenn Michael, James F. Glenn, M.D. Professor of Urology, Surgery
  • Turkington, Timothy Garvey, Associate Professor in Radiology, Radiology