Monosaccharide Transport Proteins

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  Subject Areas on Research

  • A 137-kb deletion within the Potocki-Shaffer syndrome interval on chromosome 11p11.2 associated with developmental delay and hypotonia. 
  • A gene on chromosome 11q23 coding for a putative glucose- 6-phosphate translocase is mutated in glycogen-storage disease types Ib and Ic. 
  • Acetazolamide-responsive Episodic Ataxia Without Baseline Deficits or Seizures Secondary to GLUT1 Deficiency: A Case Report and Review of the Literature. 
  • Acute interleukin-6 administration does not impair muscle glucose uptake or whole-body glucose disposal in healthy humans. 
  • Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology. 
  • Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. 
  • An adenovirus vector for efficient RNA interference-mediated suppression of target genes in insulinoma cells and pancreatic islets of langerhans. 
  • An increase in the myocardial PCr/ATP ratio in GLUT4 null mice. 
  • Autoantibodies to the GLUT-2 glucose transporter of beta cells in insulin-dependent diabetes mellitus of recent onset. 
  • Binding and signaling of surface-immobilized reagentless fluorescent biosensors derived from periplasmic binding proteins. 
  • Brain inositol is a novel stimulator for promoting Cryptococcus penetration of the blood-brain barrier. 
  • Cell surface polarization during yeast mating. 
  • Cellular engineering and gene therapy strategies for insulin replacement in diabetes. 
  • Characterization of a Na+/glucose cotransporter cloned from rabbit small intestine. 
  • Chronic growth hormone treatment in normal rats reduces post-prandial skeletal muscle plasma membrane GLUT1 content, but not glucose transport or GLUT4 expression and localization. 
  • Constitutive expression of placental lactogen in pancreatic beta cells: effects on cell morphology, growth, and gene expression. 
  • Converting a maltose receptor into a nascent binuclear copper oxygenase by computational design. 
  • Correlation of FDG-PET imaging with Glut-1 and Glut-3 expression in early-stage non-small cell lung cancer. 
  • Dehydroascorbate transport in human chondrocytes is regulated by hypoxia and is a physiologically relevant source of ascorbic acid in the joint. 
  • Describing Complex Structure-Function Relationships in Biomolecules at Equilibrium. 
  • Design of bioelectronic interfaces by exploiting hinge-bending motions in proteins. 
  • Detection and characterization of xenon-binding sites in proteins by 129Xe NMR spectroscopy. 
  • Diagnosis and management of glycogen storage disease type I: a practice guideline of the American College of Medical Genetics and Genomics. 
  • Distribution of the SGLT1 Na+/glucose cotransporter and mRNA along the crypt-villus axis of rabbit small intestine. 
  • Ectopic expression of Hel-N1, an RNA-binding protein, increases glucose transporter (GLUT1) expression in 3T3-L1 adipocytes. 
  • Effect of reduced inspired oxygen on fetal growth and maternal glucose metabolism in rat pregnancy. 
  • Engineering of glucose-stimulated insulin secretion and biosynthesis in non-islet cells. 
  • Evidence that down-regulation of beta-cell glucose transporters in non-insulin-dependent diabetes may be the cause of diabetic hyperglycemia. 
  • Evidence that forskolin binds to the glucose transporter of human erythrocytes. 
  • Exercise increases muscle GLUT-4 levels and insulin action in subjects with impaired glucose tolerance. 
  • Expression of normal and novel glucokinase mRNAs in anterior pituitary and islet cells. 
  • GLUT-2 gene transfer into insulinoma cells confers both low and high affinity glucose-stimulated insulin release. Relationship to glucokinase activity. 
  • Glucokinase and glucose transporter expression in liver and islets: implications for control of glucose homoeostasis. 
  • Glucose activates mitogen-activated protein kinase (extracellular signal-regulated kinase) through proline-rich tyrosine kinase-2 and the Glut1 glucose transporter. 
  • Glycogen storage disease type I: diagnosis and phenotype/genotype correlation. 
  • Harnessing Environmental Ca2+ for Extracellular Protein Thermostabilization. 
  • Hel-N1, an RNA-binding protein, is a ligand for an A + U rich region of the GLUT1 3' UTR. 
  • In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability. 
  • Increased glucose disposal induced by adenovirus-mediated transfer of glucokinase to skeletal muscle in vivo. 
  • Localization and quantification of glucose transporters in liver of growth-retarded fetal and neonatal rats. 
  • Localization of a domain in the FimH adhesin of Escherichia coli type 1 fimbriae capable of receptor recognition and use of a domain-specific antibody to confer protection against experimental urinary tract infection. 
  • Manipulation of ligand binding affinity by exploitation of conformational coupling. 
  • Metabolism: A is for adipokine. 
  • Molecular cloning of a novel member of the GLUT family of transporters, SLC2a10 (GLUT10), localized on chromosome 20q13.1: a candidate gene for NIDDM susceptibility. 
  • Molecular engineering of the pancreatic beta-cell. 
  • Molecular strategies for the treatment of diabetes. 
  • Morphology of proteoliposomes reconstituted with purified lac carrier protein from Escherichia coli. 
  • Muscle glycogen content and glucose uptake during exercise in humans: influence of prior exercise and dietary manipulation. 
  • Mutational analysis of potential zinc-binding residues in the active site of the enterococcal D-Ala-D-Ala dipeptidase VanX. 
  • New lessons in the regulation of glucose metabolism taught by the glucose 6-phosphatase system. 
  • Nomenclature of the GLUT/SLC2A family of sugar/polyol transport facilitators. 
  • Novel insulinoma cell lines produced by iterative engineering of GLUT2, glucokinase, and human insulin expression. 
  • Overexpression of leptin receptors in pancreatic islets of Zucker diabetic fatty rats restores GLUT-2, glucokinase, and glucose-stimulated insulin secretion. 
  • PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. 
  • PKCs Sweeten Cell Metabolism by Phosphorylation of Glut1. 
  • Plasticity of lipid-protein interactions in the function and topogenesis of the membrane protein lactose permease from Escherichia coli. 
  • Prolactin induction of insulin gene expression: the roles of glucose and glucose transporter-2. 
  • Protein kinase-zeta interacts with munc18c: role in GLUT4 trafficking. 
  • Purified lac permease and cytochrome o oxidase are functional as monomers. 
  • Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma. 
  • Reconstitution of protein translocation from detergent-solubilized Escherichia coli inverted vesicles: PrlA protein-deficient vesicles efficiently translocate precursor proteins. 
  • Regulation of beta-cell glucose transporter gene expression. 
  • Regulation of insulin secretion from novel engineered insulinoma cell lines. 
  • Retinal neovascular markers in retinopathy of prematurity: aetiological implications. 
  • STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells. 
  • Somatic SLC35A2 variants in the brain are associated with intractable neocortical epilepsy. 
  • Structural domains that contribute to substrate specificity in facilitated glucose transporters are distinct from those involved in kinetic function: studies with GLUT-1/GLUT-2 chimeras. 
  • Substrate availability and transcriptional regulation of metabolic genes in human skeletal muscle during recovery from exercise. 
  • The CD28 signaling pathway regulates glucose metabolism. 
  • The high Km glucose transporter of islets of Langerhans is functionally similar to the low affinity transporter of liver and has an identical primary sequence. 
  • The putative glucose 6-phosphate translocase gene is mutated in essentially all cases of glycogen storage disease type I non-a. 
  • The rational design of allosteric interactions in a monomeric protein and its applications to the construction of biosensors. 
  • Transfection of AtT-20ins cells with GLUT-2 but not GLUT-1 confers glucose-stimulated insulin secretion. Relationship to glucose metabolism. 
  • Underexpression of beta cell high Km glucose transporters in noninsulin-dependent diabetes. 
  • beta -Arrestin-mediated recruitment of the Src family kinase Yes mediates endothelin-1-stimulated glucose transport. 
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  Keywords of People

  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • Patz Jr., Edward F., James and Alice Chen Distinguished Professor of Radiology, Pathology