Morphine

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  Subject Areas on Research

  • A Systematic Review Evaluating Neuraxial Morphine and Diamorphine-Associated Respiratory Depression After Cesarean Delivery. 
  • A comparison of Depodur, a novel, single-dose extended-release epidural morphine, with standard epidural morphine for pain relief after lower abdominal surgery. 
  • A comparison of three methods of pain control for posterior spinal fusions in adolescent idiopathic scoliosis. 
  • A functional polymorphism in the ATP-Binding Cassette B1 transporter predicts pharmacologic response to combination of nortriptyline and morphine in neuropathic pain patients. 
  • A new method for hemodynamic and echocardiographic assessment of conscious dogs: comparison with thiopental-morphine anaesthesia. 
  • A novel alternatively spliced isoform of the mu-opioid receptor: functional antagonism. 
  • A randomized placebo-controlled trial of two doses of pregabalin for postoperative analgesia in patients undergoing abdominal hysterectomy. 
  • A retrospective assessment of the incidence of respiratory depression after neuraxial morphine administration for postcesarean delivery analgesia. 
  • A risk score for postoperative nausea and/or vomiting in women undergoing cesarean delivery with intrathecal morphine. 
  • Activation of kappa opioid receptors by U50488H and morphine enhances the release of substance P from rat trigeminal nucleus slices. 
  • Acute morphine activates satellite glial cells and up-regulates IL-1β in dorsal root ganglia in mice via matrix metalloprotease-9. 
  • Acute morphine induces matrix metalloproteinase-9 up-regulation in primary sensory neurons to mask opioid-induced analgesia in mice. 
  • Adolescent morphine exposure affects long-term microglial function and later-life relapse liability in a model of addiction. 
  • Adoptive immunotherapy with autologous T-cell infusions reduces opioid requirements in advanced cancer patients. 
  • Alteration by methadone of catecholamine uptake and release in isolated rat adrenomedullary storage vesicles. 
  • Ambulatory use of high-dose intravenous morphine for severe pain. 
  • Analgesia After Cesarean Delivery in the United States 2008-2018: A Retrospective Cohort Study. 
  • Analgesia in the surgical intensive care unit. 
  • Analgesic Effects of a Novel Combination of Regional Anesthesia After Pediatric Cardiac Surgery: A Retrospective Cohort Study. 
  • Anti-PD-1 treatment impairs opioid antinociception in rodents and nonhuman primates. 
  • Antinociceptive activity of Syzygium jambos leaves extract on rats. 
  • Anxiolytic effects of acute morphine can be modulated by nitric oxide systems. 
  • Ascaris suum, an intestinal parasite, produces morphine. 
  • Association 'Between Gabapentinoids on the Day of Colorectal Surgery and Adverse Postoperative Respiratory Outcomes. 
  • Association of Postoperative Opioid Prescription Size and Patient Satisfaction. 
  • Association of intravenous morphine use and outcomes in acute coronary syndromes: results from the CRUSADE Quality Improvement Initiative. 
  • Automated radiosynthesis of [11C]morphine for clinical investigation. 
  • Behavioral and molecular effects of dopamine D1 receptor stimulation during naloxone-precipitated morphine withdrawal. 
  • Behavioural testing and histological assessments of rabbit spinal cord following intrathecal administration of ondansetron. 
  • Car8 dorsal root ganglion expression and genetic regulation of analgesic responses are associated with a cis-eQTL in mice. 
  • Case series: Combined spinal epidural anesthesia for Cesarean delivery and ex utero intrapartum treatment procedure. 
  • Central effects of morphine on GI motility in conscious dogs. 
  • Central opioid receptors mediate morphine-induced itch and chronic itch via disinhibition. 
  • Chronic administration of U50,488H fails to produce hypothalamo-pituitary-adrenal axis tolerance in neonatal rats. 
  • Chronic morphine administration alters epinephrine uptake in rat adrenal storage vesicles. 
  • Chronic morphine induces downregulation of spinal glutamate transporters: implications in morphine tolerance and abnormal pain sensitivity. 
  • Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. 
  • Cyclosporine-inhibitable blood-brain barrier drug transport influences clinical morphine pharmacodynamics. 
  • Delayed suppression of serum luteinizing hormone after naloxone treatment in neonatal female rats. 
  • Delta-opioid-receptor activation by [D-Pen2,D-Pen5]enkephalin and morphine inhibits substance P release from trigeminal nucleus slices. 
  • DepoDur extended-release epidural morphine: reshaping postoperative care. What perioperative nurses need to know. 
  • Determination of morphine and morphine glucuronides in human plasma by 96-well plate solid-phase extraction and liquid chromatography-electrospray ionization mass spectrometry. 
  • Dexamethasone for the prophylaxis of postoperative nausea and vomiting associated with neuraxial morphine administration: a systematic review and meta-analysis. 
  • Different effects of opioid and cannabinoid receptor agonists on C-fiber-induced extracellular signal-regulated kinase activation in dorsal horn neurons in normal and spinal nerve-ligated rats. 
  • Differential Regulation of 6- and 7-Transmembrane Helix Variants of μ-Opioid Receptor in Response to Morphine Stimulation. 
  • Differential effects of naltrindole on morphine-induced tolerance and physical dependence in rats. 
  • Differential glycemic effects of morphine in diabetic and normal mice. 
  • Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice. 
  • Differential ontogeny of opioid, dopaminergic and serotonergic regulation of prolactin secretion. 
  • Drugs of abuse screening in the West Midlands: a 6 year retrospective survey of results. 
  • Early ontogeny of kappa-opioid receptor regulation of prolactin secretion in the rat. 
  • Early-life experience decreases drug-induced reinstatement of morphine CPP in adulthood via microglial-specific epigenetic programming of anti-inflammatory IL-10 expression. 
  • Effect of administration of high dose intrathecal clonidine or morphine prior to sciatic nerve section on c-Fos expression in rat lumbar spinal cord. 
  • Effect of metabotropic glutamate 5 receptor antagonists on morphine efficacy and tolerance in rats with neuropathic pain. 
  • Effects of [Nphe1]nociceptin(1-13)NH2, [Phe1(CH2-NH)Gly2]nociceptin(1- 13)NH2, and nocistatin on nociceptin inhibited constrictions of guinea pig isolated bronchus. 
  • Effects of morphine on the rat adrenal medulla. 
  • Effects of nociceptin (13-17) in pain modulation at supraspinal level in mice. 
  • Effects of specific mu and kappa opiate tolerance and abstinence on hypothalamo-pituitary-adrenal axis secretion in the rat. 
  • Efficacy of single-dose, multilevel paravertebral nerve blockade for analgesia after thoracoscopic procedures. 
  • Elevated mu-opioid receptor expression in the nucleus of the solitary tract accompanies attenuated withdrawal signs after chronic low dose naltrexone in opiate-dependent rats. 
  • Endocrine consequences of perinatal methadone exposure. 
  • Endocrine effects of methadone in rats; acute effects in adults. 
  • Enhanced morphine analgesia in mice lacking beta-arrestin 2. 
  • Enhanced rewarding properties of morphine, but not cocaine, in beta(arrestin)-2 knock-out mice. 
  • Epidural morphine treatment of pain in Guillain-Barré syndrome. 
  • Evaluation of a single-dose, extended-release epidural morphine formulation for pain after knee arthroplasty. 
  • FACS analysis of neuronal-glial interactions in the nucleus accumbens following morphine administration. 
  • Factors associated with postoperative nausea or vomiting in parturients undergoing caesarean delivery under spinal anaesthesia with intrathecal morphine: A prospective cohort study. 
  • Fascia iliaca blockade with the addition of liposomal bupivacaine vs. plain bupivacaine for perioperative pain management following hip arthroscopy. 
  • Forty-eight hours of postoperative pain relief after total hip arthroplasty with a novel, extended-release epidural morphine formulation. 
  • G-protein receptor kinase 3 (GRK3) influences opioid analgesic tolerance but not opioid withdrawal. 
  • Gabapentin attenuates morphine tolerance through interleukin-10. 
  • Gabapentin enhances the morphine anti-nociceptive effect in neuropathic pain via the interleukin-10-heme oxygenase-1 signalling pathway in rats. 
  • Human Genetic Variability Contributes to Postoperative Morphine Consumption. 
  • Iliohypogastric-ilioinguinal peripheral nerve block for post-Cesarean delivery analgesia decreases morphine use but not opioid-related side effects. 
  • Immediate hemodynamic effects of acute coronary occlusion and their modification by anesthesia. 
  • Impact of a multimodal analgesic protocol modification on opioid consumption after cesarean delivery: a retrospective cohort study. 
  • Impact of a palliative care program on end-of-life care in a neonatal intensive care unit. 
  • Impact of enhanced recovery after cesarean delivery on maternal outcomes: A systematic review and meta-analysis. 
  • Impact of human CA8 on thermal antinociception in relation to morphine equivalence in mice. 
  • Impact of morphine on antiplatelet effects of oral P2Y12 receptor inhibitors. 
  • Increased sensitivity to mu opiate antinociception in the neonatal rat despite weaker receptor-guanyl nucleotide binding protein coupling. 
  • Initial pharmacokinetic, safety and efficacy evaluation of nasal morphine gluconate for breakthrough pain in cancer patients. 
  • Intercostal muscle biopsy studies in myasthenia gravis: clinical correlations and the direct effects of drugs and myasthenic serum. 
  • Interscalene brachial plexus block with a continuous catheter insertion system and a disposable infusion pump. 
  • Intraoperative awareness and hypertensive crisis during high-dose fentanyl-diazepam-oxygen anesthesia. 
  • Intraoperative fluid management during orthotopic liver transplantation. 
  • Intrathecal PLC(β3) oligodeoxynucleotides antisense potentiates acute morphine efficacy and attenuates chronic morphine tolerance. 
  • Intrathecal ketorolac tromethamine produces analgesia after chronic constriction injury of sciatic nerve in rat. 
  • Intrathecal morphine for analgesia after postpartum bilateral tubal ligation. 
  • Intrathecal morphine for postpartum bilateral tubal ligation. 
  • Intrathecal morphine suppresses immune function in rats with inflammatory-induced pain. 
  • Lipophilicity is a critical parameter that dominates the efficacy of metalloporphyrins in blocking the development of morphine antinociceptive tolerance through peroxynitrite-mediated pathways. 
  • Low Incidence of Postoperative Respiratory Depression with Oliceridine Compared to Morphine: A Retrospective Chart Analysis. 
  • Low-dose naloxone infusion for the treatment of intractable nausea and vomiting after intrathecal morphine in a parturient. 
  • Maturation of central nervous system control of growth hormone secretion in rats. 
  • Maturation of the adrenal medulla--IV. Effects of morphine. 
  • Melanocortin-1 receptor gene variants affect pain and mu-opioid analgesia in mice and humans. 
  • Mice deficient in endothelin-converting enzyme-2 exhibit abnormal responses to morphine and altered peptide levels in the spinal cord. 
  • Microglia: a promising target for treating neuropathic and postoperative pain, and morphine tolerance. 
  • Minocycline can delay the development of morphine tolerance, but cannot reverse existing tolerance in the maintenance period of neuropathic pain in rats. 
  • Monitoring, prevention and treatment of side effects of long-acting neuraxial opioids for post-cesarean analgesia. 
  • Morphine and Cardiovascular Outcomes Among Patients With Non-ST-Segment Elevation Acute Coronary Syndromes Undergoing Coronary Angiography. 
  • Morphine and clinical outcomes in patients with ST segment elevation myocardial infarction treated with fibrinolytic and antiplatelet therapy: Insights from the TREAT trial. 
  • Morphine exposure alters Fos expression in a sex-, age-, and brain region-specific manner during adolescence. 
  • Morphine produces a biphasic modulation of substance P release from cultured dorsal root ganglion neurons. 
  • Morphine produces a multiphasic effect on the release of substance P from rat trigeminal nucleus slices by activating different opioid receptor subtypes. 
  • Morphine side effects in beta-arrestin 2 knockout mice. 
  • Morphine vs Methadone Treatment for Infants with Neonatal Abstinence Syndrome. 
  • Morphine-reserpine interactions in the adrenal medulla. 
  • Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behavior. 
  • Mu Opioid Splice Variant MOR-1K Contributes to the Development of Opioid-Induced Hyperalgesia. 
  • Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence. 
  • Multiphasic effect of morphine on the release of substance P from rat trigeminal nucleus slices. 
  • Multiphasic morphine modulation of substance P release from capsaicin-sensitive primary afferent fibers. 
  • Neuronal apoptosis associated with morphine tolerance: evidence for an opioid-induced neurotoxic mechanism. 
  • Nucleus Accumbens AMPA Receptors Are Necessary for Morphine-Withdrawal-Induced Negative-Affective States in Rats. 
  • Oliceridine in the treatment of moderate to severe acute pain. 
  • Ontogenetic studies of tolerance development: effects of chronic morphine on the hypothalamic-pituitary-adrenal axis. 
  • Ontogeny of mu- and kappa-opiate receptor control of the hypothalamo-pituitary-adrenal axis in rats. 
  • Opioid patient controlled analgesia use during the initial experience with the IMPROVE PCA trial: a phase III analgesic trial for hospitalized sickle cell patients with painful episodes. 
  • Opioid-related respiratory and gastrointestinal adverse events in patients with acute postoperative pain: prevalence, predictors, and burden. 
  • Opioid-sparing effects of a low-dose infusion of naloxone in patient-administered morphine sulfate. 
  • Orthotopic liver transplant patients require less postoperative morphine than do patients undergoing hepatic resection. 
  • Patient-specific factors affecting patient-controlled analgesia dosing. 
  • Persistent pain associated with long-term intrathecal morphine administration. 
  • Phase I clinical trial of mafosfamide in infants and children aged 3 years or younger with newly diagnosed embryonal tumors: a pediatric brain tumor consortium study (PBTC-001). 
  • Postoperative outcomes following pediatric intracranial electrode monitoring: A case for stereoelectroencephalography (SEEG). 
  • Preemptive analgesia for postoperative pain relief in thoracolumbosacral spine operations: a double-blind, placebo-controlled randomized trial. 
  • Preincisional intravenous pentoxifylline attenuating perioperative cytokine response, reducing morphine consumption, and improving recovery of bowel function in patients undergoing colorectal cancer surgery. 
  • Preoperative lumbar epidural morphine improves postoperative analgesia and ventilatory function after transsternal thymectomy in patients with myasthenia gravis. 
  • Prophylaxis and treatment of the side-effects of neuraxial morphine analgesia following cesarean delivery. 
  • Quadratus lumborum block for postoperative analgesia after cesarean delivery: A systematic review with meta-analysis and trial-sequential analysis. 
  • Quantitative trait locus and computational mapping identifies Kcnj9 (GIRK3) as a candidate gene affecting analgesia from multiple drug classes. 
  • Randomized trial of transversus abdominis plane block with liposomal bupivacaine after cesarean delivery with or without intrathecal morphine. 
  • Rapastinel accelerates loss of withdrawal signs after repeated morphine and blunts relapse to conditioned place preference. 
  • Rapid, reversible modulation of blood-brain barrier P-glycoprotein transport activity by vascular endothelial growth factor. 
  • Relative ontogeny of opioid and catecholaminergic regulation of thyrotropin secretion in the rat. 
  • Relative opioid efficacy is determined by the complements of the G protein-coupled receptor desensitization machinery. 
  • Removal of microglial-specific MyD88 signaling alters dentate gyrus doublecortin and enhances opioid addiction-like behaviors. 
  • Respiratory depression after administration of single-dose neuraxial morphine for post-cesarean delivery analgesia: a retrospective cohort study. 
  • Role for G protein-coupled receptor kinase in agonist-specific regulation of mu-opioid receptor responsiveness. 
  • Role of P-glycoprotein in the intestinal absorption and clinical effects of morphine. 
  • Role of serotonin in opiate-induced prolactin secretion and antinociception in the developing rat. 
  • Ropivacaine and Ketorolac Wound Infusion for Post-Cesarean Delivery Analgesia: A Randomized Controlled Trial. 
  • Safety and side-effect profile of intrathecal morphine in a diverse patient population undergoing total knee and hip arthroplasty. 
  • Safety of an ED High-Dose Opioid Protocol for Sickle Cell Disease Pain. 
  • Selective inhibition of JNK with a peptide inhibitor attenuates pain hypersensitivity and tumor growth in a mouse skin cancer pain model. 
  • Self-administration of morphine in bone marrow transplant patients reduces drug requirement. 
  • Serotonin receptor antagonists for the prevention and treatment of pruritus, nausea, and vomiting in women undergoing cesarean delivery with intrathecal morphine: a systematic review and meta-analysis. 
  • Single-dose extended-release epidural morphine for pain after hip arthroplasty. 
  • Single-dose extended-release epidural morphine for pain following hip arthroplasty. 
  • Society for Obstetric Anesthesia and Perinatology Consensus Statement: Monitoring Recommendations for Prevention and Detection of Respiratory Depression Associated With Administration of Neuraxial Morphine for Cesarean Delivery Analgesia. 
  • Structural basis for μ-opioid receptor binding and activation. 
  • Supraspinal inactivation of mitochondrial superoxide dismutase is a source of peroxynitrite in the development of morphine antinociceptive tolerance. 
  • Sympatho-adrenal development in perinatally addicted rats. 
  • Targeting microglial purinergic signaling to improve morphine analgesia. 
  • The James A. Rand Young Investigator's Award: Battling the Opioid Epidemic with Prospective Pain Threshold Measurement. 
  • The effect of epidural clonidine on perioperative cytokine response, postoperative pain, and bowel function in patients undergoing colorectal surgery. 
  • The effects of D1 and D2 receptor antagonists on pain sensitivity and morphine analgesia in the rat. 
  • The herbal medicine, Dai-Kenchu-to, accelerates delayed gastrointestinal transit after the operation in rats. 
  • The influence of lockout intervals and drug selection on patient-controlled analgesia following gynecological surgery. 
  • The measurement of morphine in the hair of heroin abusers. 
  • The morphine-sparing effect of metoclopramide on postoperative laparoscopic tubal ligation patients. 
  • The ontogeny of mu opiate tolerance and dependence in the rat: antinociceptive and biochemical studies. 
  • The relative potency of oral transmucosal fentanyl citrate compared with intravenous morphine in the treatment of moderate to severe postoperative pain. 
  • The role of neural input in the effects of morphine on the rat adrenal medulla. 
  • Tissue plasminogen activator contributes to morphine tolerance and induces mechanical allodynia via astrocytic IL-1β and ERK signaling in the spinal cord of mice. 
  • Transdermal nicotine for analgesia after radical retropubic prostatectomy. 
  • Transformation of mu-opioid receptor agonists into biologically potent mu-opioid receptor antagonists. 
  • Transition to post-operative epidural or patient-controlled intravenous analgesia following total intravenous anaesthesia with remifentanil and propofol for abdominal surgery. 
  • Transversus abdominis plane block for analgesia after Cesarean delivery: a systematic review and meta-analysis. 
  • Underutilization of Acetaminophen in Older Adult Trauma Patients. 
  • Unique Intradural Inflammatory Mass Containing Precipitated Morphine: Confirmatory Analysis by LESA-MS and MALDI-MS. 
  • Wheal and flare responses to muscle relaxants in humans. 
  • [Effect of intrathecal pumping morphine on immunological function in rats with formalin pain]. 
  • [Nphe1]nociceptin(1-13)-NH2 antagonizes nociceptin-induced hypotension, bradycardia, and hindquarters vasodilation in the anesthetized rat. 
  • mu-Opioid agonists stimulate growth hormone secretion in immature rats. 
  • p-Chlorophenylalanine-induced enhancement of the effects of morphine on the adrenal medulla.