Morphine Dependence

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  Subject Areas on Research

  • Chronic morphine induces downregulation of spinal glutamate transporters: implications in morphine tolerance and abnormal pain sensitivity. 
  • Gnao1 (G alphaO protein) is a likely genetic contributor to variation in physical dependence on opioids in mice. 
  • Increased rewarding properties of morphine in dopamine-transporter knockout mice. 
  • Maturation of the adrenal medulla--IV. Effects of morphine. 
  • Mice deficient in endothelin-converting enzyme-2 exhibit abnormal responses to morphine and altered peptide levels in the spinal cord. 
  • Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence. 
  • Ontogenetic studies of tolerance development: effects of chronic morphine on the hypothalamic-pituitary-adrenal axis. 
  • Pharmacodynamics of morphine-induced neuronal nitric oxide production and antinociceptive tolerance development. 
  • The development of morphine antinociceptive tolerance in nitric oxide synthase-deficient mice. 
  • The role of mitogen-activated protein kinase (MAPK) in morphine tolerance and dependence.