Motor Neurons

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  Subject Areas on Research

  • A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type. 
  • A circuit for motor cortical modulation of auditory cortical activity. 
  • A comparison of chemical and electrical synaptic transmission between single sensory cells and a motoneurone in the central nervous system of the leech. 
  • A nonpolio enterovirus with respiratory tropism causes poliomyelitis in intercellular adhesion molecule 1 transgenic mice. 
  • A stable, selective electrode for recording single motor-unit potentials in humans. 
  • A ubiquitin E2 variant protein acts in axon termination and synaptogenesis in Caenorhabditis elegans. 
  • ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects. 
  • Accuracy of regenerating motor neurons: influence of diffusion in denervated nerve. 
  • Acetyl-L-carnitine deficiency as a cause of altered nerve myo-inositol content, Na,K-ATPase activity, and motor conduction velocity in the streptozotocin-diabetic rat. 
  • Adaptation of cat motoneurons to sustained and intermittent extracellular activation. 
  • Agrin is required for posterior development and motor axon outgrowth and branching in embryonic zebrafish. 
  • Altered expression of pp60c-src induced by peripheral nerve injury. 
  • An electron-microscopic study of a physiologically identified motoneurone in the leech C.N.S. after injection of the fluorescent dye Procion yellow. 
  • An in vivo model to quantify motor and sensory peripheral nerve regeneration using bioresorbable nerve guide tubes. 
  • An interdomain interaction of the androgen receptor is required for its aggregation and toxicity in spinal and bulbar muscular atrophy. 
  • Analysis of amplitude and area of concentric needle EMG motor unit action potentials. 
  • Analysis of the electromyographic interference pattern. 
  • Argonaute2 suppresses Drosophila fragile X expression preventing neurogenesis and oogenesis defects. 
  • Automatic analysis of the electromyographic interference pattern. Part II: Findings in control subjects and in some neuromuscular diseases. 
  • Behavior of motor units in human biceps brachii during a submaximal fatiguing contraction. 
  • Behavioral deficits during early stages of aging in Caenorhabditis elegans result from locomotory deficits possibly linked to muscle frailty. 
  • Behavioral learning. The illuminated songbird. 
  • Biomarkers for amyotrophic lateral sclerosis. 
  • Brain stem as a target site for the metabolic side effects of olanzapine. 
  • Cellular and Synaptic Properties of Local Inhibitory Circuits. 
  • Characteristics of antidromically identified oculomotor internuclear neurons during vergence and versional eye movements. 
  • Characterization of excitatory amino acid receptors expressed by embryonic chick motoneurons in vitro. 
  • Clinical outcomes following brachialis to anterior interosseous nerve transfers. 
  • Composition and topographic organization of signals sent from the frontal eye field to the superior colliculus. 
  • Conduction block and continuous motor unit activity in chronic acquired demyelinating polyneuropathy. 
  • Constructing an adult orofacial premotor atlas in Allen mouse CCF. 
  • Controlling robots with the mind. 
  • Converting neural signals from place codes to rate codes. 
  • Corollary discharge across the animal kingdom. 
  • Cultured motor neurons possess calcium-permeable AMPA/kainate receptors. 
  • Determinants of poliovirus neurovirulence. 
  • Development of the single microelectrode current and voltage clamp for central nervous system neurons. 
  • Differential effects of anesthetic agents on outcome from near-complete but not incomplete global ischemia in the rat. 
  • Directed axonal outgrowth using a propagating gradient of IGF-1. 
  • Distributions of choline acetyltransferase and acetylcholinesterase activities in the retinal layers of the red-tailed hawk and road runner. 
  • Diversity of neural responses in the brainstem during smooth pursuit eye movements constrains the circuit mechanisms of neural integration. 
  • Dynamics of auditory-vocal interaction in monkey auditory cortex. 
  • Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial. 
  • Electromyographic assessment of ulnar nerve motor block induced by lidocaine. 
  • Evaluation of an automatic method of measuring features of motor unit action potentials. 
  • Excitatory synaptic transmission between interneurons and motoneurons in chick spinal cord cell cultures. 
  • Experience-dependent changes in cerebellar contributions to motor sequence learning. 
  • Extracellular stimulation of central neurons: influence of stimulus waveform and frequency on neuronal output. 
  • Factors contributing to preferential motor reinnervation in the primate peripheral nervous system. 
  • Factors that influence peripheral nerve regeneration: an electrophysiological study of the monkey median nerve. 
  • Fas(t) balls and Lou Gehrig disease. A clue to selective vulnerability of motor neurons? 
  • Fasciated nerve-muscle explants for in vitro comparison of magnetic and electrical neuromuscular stimulation. 
  • Fibroblast growth factors regulate calcitonin gene-related peptide mRNA expression in rat motoneurons after lesion and in culture. 
  • Fluid and electrolyte status in athletes receiving medical care at an ultradistance triathlon. 
  • Functional effects of lymphotoxin on crushed peripheral nerve. 
  • Genetic Correction of SOD1 Mutant iPSCs Reveals ERK and JNK Activated AP1 as a Driver of Neurodegeneration in Amyotrophic Lateral Sclerosis. 
  • Hand weakness in elderly patients. 
  • Hand weakness in the elderly. 
  • Homogeneity of intrinsic properties of sexually dimorphic vocal motoneurons in male and female zebra finches. 
  • Human genetics. Did radicals strike Lou Gehrig? 
  • Immobilization-induced changes in motor unit force and fatigability in the cat. 
  • Induction and maintenance of increased VEGF protein by chronic motor nerve stimulation in skeletal muscle. 
  • Influence of terminal nerve branch size on motor neuron regeneration accuracy. 
  • Inhibition, Not Excitation, Drives Rhythmic Whisking. 
  • Isolation of embryonic chick motoneurons and their survival in vitro. 
  • Jagged2 controls the generation of motor neuron and oligodendrocyte progenitors in the ventral spinal cord. 
  • LIM homeobox gene-dependent expression of biogenic amine receptors in restricted regions of the C. elegans nervous system. 
  • Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes. 
  • Loss of tubulin deglutamylase CCP1 causes infantile-onset neurodegeneration. 
  • Lower extremity neuromuscular recovery following anterior cruciate ligament reconstruction; a 2-week case study. 
  • Lumbar plexus and sciatic nerve block for knee arthroplasty: comparison of ropivacaine and bupivacaine. 
  • MEF2 responds to multiple calcium-regulated signals in the control of skeletal muscle fiber type. 
  • MUAP analysis using Bayes classifier. 
  • Manipulations of the mouse femoral nerve influence the accuracy of pathway reinnervation by motor neurons. 
  • Mechanisms underlying reversal of motor unit activation order in electrically evoked contractions after spinal cord injury. 
  • Metabolic variation among rat lumbosacral alpha-motoneurons. 
  • Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons. 
  • Modeling the excitability of mammalian nerve fibers: influence of afterpotentials on the recovery cycle. 
  • Modularity of motor output evoked by intraspinal microstimulation in cats. 
  • Modulation of embryonic chick motoneuron glutamate sensitivity by interneurons and agonists. 
  • Monoclonal antibody interaction with the third immunoglobulin-like domain of N-CAM is sufficient to cause cell migration. 
  • Monosynaptic premotor circuit tracing reveals neural substrates for oro-motor coordination. 
  • Motor innervation of the cricopharyngeus muscle by the recurrent laryngeal nerve. 
  • Motor neuron disease presenting with respiratory failure. Report of two cases. 
  • Motor neuron regeneration accuracy: balancing trophic influences between pathways and end-organs. 
  • Motor neuron target selectivity and survival after prolonged axotomy. 
  • Motor neurons can preferentially reinnervate cutaneous pathways. 
  • Motor systems: understanding motor circuits: where bottom-up meets top-down. 
  • Mouse transgenic lines that selectively label Type I, Type IIA, and Types IIX+B skeletal muscle fibers. 
  • Muscle-Derived Extracellular Vesicles Influence Motor Neuron Regeneration Accuracy. 
  • Neural substrate of modified and unmodified pathways for learning in monkey vestibuloocular reflex. 
  • Neuropathology in respiratory-related motoneurons in young Pompe (Gaa(-/-)) mice. 
  • Neurotrophins: peripherally and centrally acting modulators of tactile stimulus-induced inflammatory pain hypersensitivity. 
  • On the mechanism of acetylcholine receptor accumulation at newly formed synapses on chick myotubes. 
  • Optimization of magnetic neurostimulation waveforms for minimum power loss. 
  • Optimizing a linear algorithm for real-time robotic control using chronic cortical ensemble recordings in monkeys. 
  • Pancreatic polypeptide microinjection into the dorsal motor nucleus inhibits pancreatic secretion in rats. 
  • Parallel Inhibitory and Excitatory Trigemino-Facial Feedback Circuitry for Reflexive Vibrissa Movement. 
  • Phase 2 study of sodium phenylbutyrate in ALS. 
  • Phrenic long-term facilitation requires PKCθ activity within phrenic motor neurons. 
  • Phrenic motor neuron TrkB expression is necessary for acute intermittent hypoxia-induced phrenic long-term facilitation. 
  • Plasticity in the vestibulo-ocular reflex: a new hypothesis. 
  • Polyethylene glycol fusion repair prevents reinnervation accuracy in rat peripheral nerve. 
  • Polysialic acid expression is not necessary for motor neuron target selectivity. 
  • Preferential motor reinnervation in the mouse: comparison of femoral nerve repair using a fibrin sealant or suture. 
  • Protective effect of 21-aminosteroid pretreatment in peripheral nerve low-load crush injury in mature and immature rats. 
  • Quantitative electromyographic analysis of levator ani and external anal sphincter muscles of nulliparous women. 
  • Quantitative motor unit potential analysis. 
  • Real-time prediction of hand trajectory by ensembles of cortical neurons in primates. 
  • Recording and physical characteristics of disposable concentric needle EMG electrodes. 
  • Recording characteristics of monopolar EMG electrodes. 
  • Reinnervation accuracy of the rat femoral nerve by motor and sensory neurons. 
  • Repetitive nerve stimulation studies in the Lambert-Eaton myasthenic syndrome. 
  • Respiratory and telencephalic modulation of vocal motor neurons in the zebra finch. 
  • Respiratory pathology in the Optn-/- mouse model of Amyotrophic Lateral Sclerosis. 
  • Responses during eye movements of brain stem neurons that receive monosynaptic inhibition from the flocculus and ventral paraflocculus in monkeys. 
  • Retrograde gene delivery to hypoglossal motoneurons using adeno-associated virus serotype 9. 
  • Retrograde influence of muscle fibers on their innervation revealed by a novel marker for slow motoneurons. 
  • Saccades to somatosensory targets. II. motor convergence in primate superior colliculus. 
  • Saccades to somatosensory targets. III. eye-position-dependent somatosensory activity in primate superior colliculus. 
  • Schwann cell influence on motor neuron regeneration accuracy. 
  • Senataxin mutations elicit motor neuron degeneration phenotypes and yield TDP-43 mislocalization in ALS4 mice and human patients. 
  • Sensory, motor, and combined contexts for context-specific adaptation of saccade gain in humans. 
  • Sensory-motor interaction in the primate auditory cortex during self-initiated vocalizations. 
  • Severe muscle wasting and denervation in mice lacking the RNA-binding protein ZFP106. 
  • Simulation and analysis of the electromyographic interference pattern in normal muscle. Part II: Activity, upper centile amplitude, and number of small segments. 
  • Simulation of concentric needle EMG motor unit action potentials. 
  • Simulation of myopathic motor unit action potentials. 
  • Simulation techniques in electromyography. 
  • Spasticity: actions of selectivity activated group II muscle spindle afferents on extensor motoneurons. 
  • Special-purpose orthonormal basis functions--application to motor unit action potentials. 
  • Specific connections between nerve cells. 
  • Spinal activation of protein kinase C elicits phrenic motor facilitation. 
  • Spontaneous cortical activity in awake monkeys composed of neuronal avalanches. 
  • Stabilizing electrode-host interfaces: a tissue engineering approach. 
  • Structure of the human sensorimotor system. II: Lateral symmetry. 
  • Supratrigeminal Bilaterally Projecting Neurons Maintain Basal Tone and Enable Bilateral Phasic Activation of Jaw-Closing Muscles. 
  • Sustained Hypoxia Elicits Competing Spinal Mechanisms of Phrenic Motor Facilitation. 
  • Sustained correction of motoneuron histopathology following intramuscular delivery of AAV in pompe mice. 
  • Syncoilin modulates peripherin filament networks and is necessary for large-calibre motor neurons. 
  • Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation. 
  • Task and fatigue effects on low-threshold motor units in human hand muscle. 
  • The coming-of-age of nucleocytoplasmic transport in motor neuron disease and neurodegeneration. 
  • The development and recovery of motor function in spinal cats. I. The infant lesion effect. 
  • The development and recovery of motor function in spinal cats. II. Pharmacological enhancement of recovery. 
  • The development of a technique to estimate the number of motor units in the urethral sphincter. 
  • The distribution of synapses on a physiologically identified motor neuron in the central nervous system of the leech. An electron microscope study after the injection of the fluorescent dye procion yellow. 
  • The respiratory neuromuscular system in Pompe disease. 
  • The role of the thalamus in motor control. 
  • The specificity of motor neurone regeneration (preferential reinnervation). 
  • Topographic specificity within membranes of a single muscle detected in vitro. 
  • Trophic effects of androgen: development and hormonal regulation of neuron number in a sexually dimorphic vocal motor nucleus. 
  • What the brain stem tells the frontal cortex. II. Role of the SC-MD-FEF pathway in corollary discharge. 
  • Wireless Cortical Brain-Machine Interface for Whole-Body Navigation in Primates. 
  • Zebrafish Erc1b mediates motor innervation and organization of craniofacial muscles in control of jaw movement. 
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  Keywords of People

  • Nicolelis, Miguel Angelo L., Professor Emeritus of Neurobiology, Neurobiology
  • Tsalik, Ephraim, Adjunct Associate Professor in the Department of Medicine, Medicine, Infectious Diseases