Multiple Sclerosis

• 

  Subject Areas on Research

  • A PheWAS approach in studying HLA-DRB1*1501. 
  • A Requirement of Protein Geranylgeranylation for Chemokine Receptor Signaling and Th17 Cell Function in an Animal Model of Multiple Sclerosis. 
  • A complete genomic screen for multiple sclerosis underscores a role for the major histocompatability complex. The Multiple Sclerosis Genetics Group. 
  • A comprehensive assessment of the cost of multiple sclerosis in the United States. 
  • A high-density screen for linkage in multiple sclerosis. 
  • A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis. The Optic Neuritis Study Group. 
  • A second major histocompatibility complex susceptibility locus for multiple sclerosis. 
  • A second-generation genomic screen for multiple sclerosis. 
  • Access to multiple sclerosis specialty care. 
  • Active MS is associated with accelerated retinal ganglion cell/inner plexiform layer thinning. 
  • Allelic association of sequence variants in the herpes virus entry mediator-B gene (PVRL2) with the severity of multiple sclerosis. 
  • Alternative Approaches to Valuing Intangible Health Losses: The Evidence for Multiple Sclerosis 
  • Alternative splicing in multiple sclerosis and other autoimmune diseases. 
  • An application of Random Forests to a genome-wide association dataset: methodological considerations & new findings. 
  • An interferon-β-resistant and NLRP3 inflammasome-independent subtype of EAE with neuronal damage. 
  • Analysis of current multiple sclerosis registries. 
  • Anti-phospholipid antibodies in patients with multiple sclerosis and MS-like illnesses: MS or APS? 
  • Apolipoprotein E-derived peptides ameliorate clinical disability and inflammatory infiltrates into the spinal cord in a murine model of multiple sclerosis. 
  • Application of stem cell transplantation in autoimmune diseases. 
  • Assessing abnormal iron content in the deep gray matter of patients with multiple sclerosis versus healthy controls. 
  • Association Between Neighborhood Socioeconomic Status and 30-Day Mortality and Readmission for Patients With Common Neurologic Conditions. 
  • Association between cell-mediated demyelination and astrocyte stimulation. 
  • Association of polymorphisms in the apolipoprotein E region with susceptibility to and progression of multiple sclerosis. 
  • Autologous Hematopoietic Cell Transplantation for Treatment-Refractory Relapsing Multiple Sclerosis: Position Statement from the American Society for Blood and Marrow Transplantation. 
  • B cell depletion and pregnancy: Review and applications for MS treatment. 
  • B-lymphocyte depletion for the treatment of multiple sclerosis: now things really get interesting. 
  • Biomarkers and Surrogate End points in Multiple Sclerosis Trials: Regulatory Issues. 
  • Body composition in ambulatory women with multiple sclerosis. 
  • Brain and retinal atrophy in African-Americans versus Caucasian-Americans with multiple sclerosis: a longitudinal study. 
  • CAR T cells and checkpoint inhibition for the treatment of glioblastoma. 
  • CC-chemokine receptor 5 polymorphism and age of onset in familial multiple sclerosis. Multiple Sclerosis Genetics Group. 
  • CX(3)CR1 drives cytotoxic CD4(+)CD28(-) T cells into the brain of multiple sclerosis patients. 
  • Cellular inhibitor of apoptosis 2 (cIAP2) restricts neuroinflammation during experimental autoimmune encephalomyelitis. 
  • Changing Paradigms and Unmet Needs in Multiple Sclerosis: The Role of Clinical Neurophysiology. 
  • Characterizing chronic pain phenotypes in multiple sclerosis: a nationwide survey study. 
  • Chromosome 17q22-q24 and multiple sclerosis genetic susceptibility. American-French Multiple Sclerosis Genetic Group. 
  • Circulating adhesion molecules and inflammatory mediators in demyelination: a review. 
  • Cleavage and polyadenylation specificity factor 1 (CPSF1) regulates alternative splicing of interleukin 7 receptor (IL7R) exon 6. 
  • Clinical characteristics of African Americans vs Caucasian Americans with multiple sclerosis. 
  • Clonal expansion and decreased occurrence of peripheral blood gamma delta T cells of the V delta 2J delta 3 lineage in multiple sclerosis patients. 
  • Complex gene-gene interactions in multiple sclerosis: a multifactorial approach reveals associations with inflammatory genes. 
  • Cost of multiple sclerosis by level of disability: a review of literature. 
  • Criteria to determine disability related to multiple sclerosis. 
  • Cross-regional homeostatic and reactive glial signatures in multiple sclerosis. 
  • Curcumin β-D-Glucuronide Modulates an Autoimmune Model of Multiple Sclerosis with Altered Gut Microbiota in the Ileum and Feces. 
  • Curdlan, a Microbial β-Glucan, Has Contrasting Effects on Autoimmune and Viral Models of Multiple Sclerosis. 
  • Currently approved and emerging oral therapies in multiple sclerosis: An update for the ophthalmologist. 
  • Decreased suppressor-inducer T lymphocytes in multiple sclerosis and other neurological diseases. 
  • Dectin-1 limits autoimmune neuroinflammation and promotes myeloid cell-astrocyte crosstalk via Card9-independent expression of Oncostatin M. 
  • Design, methodological issues and participation in a multiple sclerosis case-control study. 
  • Detection of sequences homologous to human retroviral DNA in multiple sclerosis by gene amplification. 
  • Determination of multiple sclerosis plaque size with diffusion-tensor MR Imaging: comparison study with healthy volunteers. 
  • Diagnostic and Therapeutic Challenges. 
  • Diffusional Kurtosis Imaging of the Corticospinal Tract in Multiple Sclerosis: Association with Neurologic Disability. 
  • Disability fingerprints: patterns of disability in spinal cord injury and multiple sclerosis differ. 
  • Drug companies seek MS patients to lobby for new products. 
  • Early complement genes are associated with visual system degeneration in multiple sclerosis. 
  • Early predictors of rapidly evolving multiple sclerosis: A case report. 
  • Editorial: Licensing and Use of New Therapies in MS: Where Are We Going? 
  • Effect of a transactional model education program on coping effectiveness in women with multiple sclerosis. 
  • Effective treatment of models of multiple sclerosis by matrix metalloproteinase inhibitors. 
  • Efficacy and toxicity of cyclosporine in chronic progressive multiple sclerosis: a randomized, double-blinded, placebo-controlled clinical trial. The Multiple Sclerosis Study Group. 
  • Elevated levels of soluble interleukin-2 receptors in multiple sclerosis. 
  • Enhancing linkage analysis of complex disorders: an evaluation of high-density genotyping. 
  • Enhancing physical activity adherence and well-being in multiple sclerosis: a randomised controlled trial. 
  • Episodic Past, Future, and counterfactual thinking in Relapsing-Remitting Multiple sclerosis. 
  • Epstein Barr virus nuclear antigen 1 (EBNA-1) peptides recognized by adult multiple sclerosis patient sera induce neurologic symptoms in a murine model. 
  • Epstein-Barr virus-associated posttransplantation lymphoproliferative disorder after high-dose immunosuppressive therapy and autologous CD34-selected hematopoietic stem cell transplantation for severe autoimmune diseases. 
  • Evaluation of magnetic resonance imaging sensitivity in patients with relapsing remitting multiple sclerosis: baseline versus Betaseron treatment trials. 
  • Evidence for CRHR1 in multiple sclerosis using supervised machine learning and meta-analysis in 12,566 individuals. 
  • Examination of seven candidate regions for multiple sclerosis: strong evidence of linkage to chromosome 1q44. 
  • Extension and Evaluation of the PROMIS Sexual Function and Satisfaction Measures for Use in Adults Living With Multiple Sclerosis. 
  • Extension and Evaluation of the PROMIS Sexual Function and Satisfaction Measures for Use in Adults Living with Multiple Sclerosis. 
  • Fatigue and fluid hydration status in multiple sclerosis: A hypothesis. 
  • Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis. 
  • Force-pain relationship in functional magnetic and electrical stimulation of subjects with paresis and preserved sensation. 
  • Galectin-1 is essential for the induction of MOG35-55 -based intravenous tolerance in experimental autoimmune encephalomyelitis. 
  • Genetic basis for clinical expression in multiple sclerosis. 
  • Genetics of multiple sclerosis. 
  • Genome-wide Pleiotropy Between Parkinson Disease and Autoimmune Diseases. 
  • Genome-wide association study of severity in multiple sclerosis. 
  • Glatiramer acetate: successful desensitization for treatment of multiple sclerosis. 
  • HLA-DR15 haplotype and multiple sclerosis: a HuGE review. 
  • HLA-DR2 dose effect on susceptibility to multiple sclerosis and influence on disease course. 
  • Heavy metals, organic solvents, and multiple sclerosis: An exploratory look at gene-environment interactions. 
  • High- and low-risk profiles for the development of multiple sclerosis within 10 years after optic neuritis: experience of the optic neuritis treatment trial. 
  • High-dose immunosuppressive therapy and autologous peripheral blood stem cell transplantation for severe multiple sclerosis. 
  • Human Epistatic Interaction Controls IL7R Splicing and Increases Multiple Sclerosis Risk. 
  • Human herpesvirus 6 polymerase chain reaction findings in human immunodeficiency virus associated neurological disease and multiple sclerosis. 
  • IFN-beta inhibits human Th17 cell differentiation. 
  • IL-11 in multiple sclerosis. 
  • IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production. 
  • Imaging inflammation: direct visualization of perivascular cuffing in EAE by magnetic resonance microscopy. 
  • Immunization and MS: a summary of published evidence and recommendations. 
  • Immunologic parameters in chronic fatigue syndrome, major depression, and multiple sclerosis. 
  • Immunological abnormalities in the tears of multiple sclerosis patients. 
  • Immunomodulation of experimental autoimmune encephalomyelitis by helminth ova immunization. 
  • Immunosuppressive/Autoimmune Disorders. 
  • In vivo assessment of retinal neuronal layers in multiple sclerosis with manual and automated optical coherence tomography segmentation techniques. 
  • Incidence of fractures in a cohort of veterans with chronic multiple sclerosis or traumatic spinal cord injury. 
  • Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains. 
  • Inflammasome activation in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE). 
  • Integrating Dignity Therapy and Family Therapy in Palliative Care: A Case Study of Multiple Sclerosis, Depression, and Comorbid Cancer. 
  • Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis. 
  • Investigation of seven proposed regions of linkage in multiple sclerosis: an American and French collaborative study. 
  • Iron stores and cerebral veins in MS studied by susceptibility weighted imaging. 
  • Laboratory testing for lyme neuroborreliosis--reply. 
  • Linkage analysis of candidate myelin genes in familial multiple sclerosis. 
  • Linkage and association analysis of chromosome 19q13 in multiple sclerosis. 
  • Linkage and association with the NOS2A locus on chromosome 17q11 in multiple sclerosis. 
  • Linkage of the MHC to familial multiple sclerosis suggests genetic heterogeneity. The Multiple Sclerosis Genetics Group. 
  • Lung inflammation stalls Th17-cell migration en route to the central nervous system during the development of experimental autoimmune encephalomyelitis. 
  • Lyme disease: authentic imitator or wishful imitation? 
  • MR imaging in multiple sclerosis: review and recommendations for current practice. 
  • Magnetic resonance imaging in multiple sclerosis: decreased signal in thalamus and putamen. 
  • Management of difficult cases in female urology and neurourology at the Reed M. Nesbit society meeting. Festschrift in honor of Edward J. McGuire, MD. 
  • Manufacture of Autologous CD34+ Selected Grafts in the NIAID-Sponsored HALT-MS and SCOT Multicenter Clinical Trials for Autoimmune Diseases. 
  • Mapping multiple sclerosis susceptibility to the HLA-DR locus in African Americans. 
  • Measures of physical and cognitive function and work status among individuals with multiple sclerosis: a review of the literature. 
  • Meta-analysis of the correlation between chronic cerebrospinal venous insufficiency and multiple sclerosis. 
  • Metabolome-based signature of disease pathology in MS. 
  • Mini-forum on multiple sclerosis (MS) and hyperbaric oxygen therapy. 
  • Mortality among autoworkers manufacturing electronics in Huntsville, Alabama. 
  • Multifactor dimensionality reduction reveals gene-gene interactions associated with multiple sclerosis susceptibility in African Americans. 
  • Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility. 
  • Multiple sclerosis lesions: relationship between MR enhancement pattern and magnetization transfer effect. 
  • Multiple sclerosis patients' benefit-risk preferences: serious adverse event risks versus treatment efficacy. 
  • Multiple sclerosis risk after optic neuritis: final optic neuritis treatment trial follow-up. 
  • Multiple sclerosis, retroviruses, and PCR. The HTLV-MS Working Group. 
  • Multiple sclerosis: diffusion tensor MR imaging for evaluation of normal-appearing white matter. 
  • Multiple susceptibility loci for multiple sclerosis. 
  • Neurologic impairment 10 years after optic neuritis. 
  • Neuronal vulnerability and multilineage diversity in multiple sclerosis. 
  • New and emerging disease modifying therapies for multiple sclerosis. 
  • New developments in Sjögren's syndrome. 
  • Normal interleukin-7 (IL7) levels and normal IL7 response to CD4 T lymphopenia in patients with multiple sclerosis and systemic sclerosis. 
  • Novel mechanisms of immune modulation of natalizumab in multiple sclerosis patients. 
  • Optic neuritis in Singapore. 
  • Osteopontin polymorphisms and disease course in multiple sclerosis. 
  • PTPRC (CD45) is not associated with the development of multiple sclerosis in U.S. patients. 
  • Palliative treatment of dysphonia and dysarthria. 
  • Pars planitis: clinical features and class II HLA associations. 
  • Pattern Recognition Receptors in Multiple Sclerosis and Its Animal Models. 
  • Pediatric Neurology 2014 Trainee Publication Award Winner: Dr. Mitchel T. Williams. 
  • Penile prosthesis for impotence in multiple sclerosis. 
  • Peptic ulcer in myasthenia gravis. 
  • Physiological basis of fatigue. 
  • Preliminary evidence that self-efficacy predicts physical activity in multiple sclerosis. 
  • Primary retinal pathology in multiple sclerosis as detected by optical coherence tomography. 
  • Purkinje cell loss in experimental autoimmune encephalomyelitis. 
  • Quantification of contrast in clinical MR brain imaging at high magnetic field. 
  • Quantifying six-minute walk induced gait deterioration with inertial sensors in multiple sclerosis subjects. 
  • Rapid transfer of knowledge for multiple sclerosis clinical care during COVID-19: ECHO MS. 
  • Real-world evidence: One tweet at a time. 
  • Real-world walking in multiple sclerosis: Separating capacity from behavior. 
  • Redefinition of multiple sclerosis plaque size using diffusion tensor MRI. 
  • Registry studies of long-term multiple sclerosis outcomes: description of key registries. 
  • Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions. 
  • Relationships between retinal axonal and neuronal measures and global central nervous system pathology in multiple sclerosis. 
  • Relevance of religion and spirituality in German patients with chronic diseases. 
  • Remotely engaged: Lessons from remote monitoring in multiple sclerosis. 
  • Retinal damage and vision loss in African American multiple sclerosis patients. 
  • Risk alleles for multiple sclerosis identified by a genomewide study. 
  • Risk of multiple sclerosis exacerbation during pregnancy and breast-feeding. 
  • SNPs in Multi-species Conserved Sequences (MCS) as useful markers in association studies: a practical approach. 
  • Scan-stratified case-control sampling for modeling blood-brain barrier integrity in multiple sclerosis. 
  • Self-efficacy and environmental correlates of physical activity among older women and women with multiple sclerosis. 
  • Sequence variation in the transforming growth factor-beta1 (TGFB1) gene and multiple sclerosis susceptibility. 
  • Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes. 
  • Socioeconomic trends in hospitalization for multiple sclerosis. 
  • Statins' immunomodulatory potential against Th17 cell-mediated autoimmune response. 
  • Stem Cell Therapy as a Treatment for Autoimmune Disease-Updates in Lupus, Scleroderma, and Multiple Sclerosis. 
  • Synthesis and Biological Evaluation of Subglutinol Analogs for Immunomodulatory Agents. 
  • T cell subsets and disease progression after total lymphoid irradiation in chronic progressive multiple sclerosis. 
  • T2 hyperintensity of medial lemniscus is an indicator of small-vessel disease. 
  • T2 hyperintensity of medial lemniscus: higher threshold application to ROI measurements is more accurate in predicting small vessel disease. 
  • The Aryl Hydrocarbon Receptor: A Mediator and Potential Therapeutic Target for Ocular and Non-Ocular Neurodegenerative Diseases. 
  • The Pediatric Optic Neuritis Prospective Outcomes Study: Two-Year Results. 
  • The clinical profile of optic neuritis. Experience of the Optic Neuritis Treatment Trial. Optic Neuritis Study Group. 
  • The e-MSWS-12: improving the multiple sclerosis walking scale using item response theory. 
  • The effect of corticosteroids for acute optic neuritis on the subsequent development of multiple sclerosis. The Optic Neuritis Study Group. 
  • The effect of total lymphoid irradiation and low-dose steroids on T lymphocyte populations in multiple sclerosis: correlation with clinical and MRI status. 
  • The fine specificity of human T cell lines towards myelin basic protein peptides in southern Italian multiple sclerosis patients. 
  • The genetic epidemiology of multiple sclerosis. 
  • The role of endogenous IFN-β in the regulation of Th17 responses in patients with relapsing-remitting multiple sclerosis. 
  • The role of interferon-β in the treatment of multiple sclerosis and experimental autoimmune encephalomyelitis - in the perspective of inflammasomes. 
  • The self-reported functional measure: Predictive validity for health care utilization in multiple sclerosis and spinal cord injury. 
  • Therapeutic Effect of Anti-CD52 Monoclonal Antibody in Multiple Sclerosis and Its Animal Models Is Mediated via T Regulatory Cells. 
  • Total lymphoid irradiation as an immunosuppressive agent for transplantation and the treatment of 'autoimmune' disease: a review. 
  • Transient smartphone blindness: Relevance to misdiagnosis in neurologic practice. 
  • Treating cognitive deficits in multiple sclerosis: are we there yet? 
  • Understanding the Physiological Significance of Four Inertial Gait Features in Multiple Sclerosis. 
  • Use of aripiprazole in a patient with multiple sclerosis presenting with paranoid psychosis. 
  • Utility of postmortem magnetic resonance imaging in clinical neuropathology. 
  • Validity of an observation method for assessing pain behavior in individuals with multiple sclerosis. 
  • Validity of brain MRI as the primary outcome criterion in multiple sclerosis phase II clinical trials. 
  • Variation within DNA repair pathway genes and risk of multiple sclerosis. 
  • Visual function 15 years after optic neuritis: a final follow-up report from the Optic Neuritis Treatment Trial. 
  • Visual function 5 years after optic neuritis: experience of the Optic Neuritis Treatment Trial. The Optic Neuritis Study Group. 
  • Visual function more than 10 years after optic neuritis: experience of the optic neuritis treatment trial. 
  • [NLRP3 inflammasome and multiple sclerosis/EAE]. 
  • miR-17-92 cluster targets phosphatase and tensin homology and Ikaros Family Zinc Finger 4 to promote TH17-mediated inflammation. 
• 

  Keywords of People

  • Hudak, Nicholas Mark, Associate Professor in Family Medicine and Community Health, Family Medicine and Community Health, Physician Assistant Program
  • Johnson, G. Allan, Charles E. Putman University Distinguished Professor of Radiology, Biomedical Engineering
  • Kimbrough, Dorlan J, Assistant Professor of Neurology, Neurology, MS & Neuroimmunology
  • Lackey, Elijah, House Staff, Medicine
  • Shinohara, Mari L., Professor of Integrative Immunobiology, Cell Biology