Muscle Proteins

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  Subject Areas on Research

  • 4-Aminopyridine attenuates muscle atrophy after sciatic nerve crush injury in mice. 
  • A common SCN5A polymorphism attenuates a severe cardiac phenotype caused by a nonsense SCN5A mutation in a Chinese family with an inherited cardiac conduction defect. 
  • A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling. 
  • Acceleration of myosin light chain dephosphorylation and relaxation of smooth muscle by telokin. Synergism with cyclic nucleotide-activated kinase. 
  • Accessory subunit KChIP2 modulates the cardiac L-type calcium current. 
  • Active involvement of PKC for insulin-mediated rates of muscle protein synthesis in Zucker rats. 
  • Adaptive Activation of a Stress Response Pathway Improves Learning and Memory Through Gs and β-Arrestin-1-Regulated Lactate Metabolism. 
  • Administration of atrial natriuretic factor inhibits sodium-coupled transport in proximal tubules. 
  • Akt signalling through GSK-3beta, mTOR and Foxo1 is involved in human skeletal muscle hypertrophy and atrophy. 
  • Alpha-2 macroglobulin in Alzheimer's disease: a marker of neuronal injury through the RCAN1 pathway. 
  • Altered stored calcium release in skeletal myotubes deficient of triadin and junctin. 
  • An epilepsy/dyskinesia-associated mutation enhances BK channel activation by potentiating Ca2+ sensing. 
  • Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma. 
  • Analysis of enriched rare variants in JPH2-encoded junctophilin-2 among Greater Middle Eastern individuals reveals a novel homozygous variant associated with neonatal dilated cardiomyopathy. 
  • Antibodies in sera of patients with late-onset myasthenia gravis recognize the PEVK domain of titin. 
  • Assembly of the dystrophin-associated protein complex does not require the dystrophin COOH-terminal domain. 
  • Association of genetic variants of FBXO32 and FOXO6 in the FOXO pathway with breast cancer risk. 
  • Atomic force microscopy captures length phenotypes in single proteins. 
  • Being there: cellular targeting of voltage-gated sodium channels in the heart. 
  • Biochemical comparison of fast- and slow-contracting squid muscle. 
  • Biological cross-reactivity of rat testis phosphodiesterase activator protein and rabbit skeletal muscle troponin-C. 
  • Ca2+-dependent regulation of cyclic-AMP phosphodiesterase by parvalbumin. 
  • Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites. 
  • Calcium control of muscle phosphorylase kinase through the combined action of calmodulin and troponin. 
  • Calcium-dependent gene regulation in myocyte hypertrophy and remodeling. 
  • Cardiac micro-computed tomography for morphological and functional phenotyping of muscle LIM protein null mice. 
  • Cardiac tissue engineering: cell seeding, cultivation parameters, and tissue construct characterization. 
  • Cardiac-specific LIM protein FHL2 modifies the hypertrophic response to beta-adrenergic stimulation. 
  • Cellular and functional defects in a mouse model of heart failure. 
  • Characterization of two labor-induced genes, DSCR1 and TCTE1L, in the pregnant ovine myometrium. 
  • Chronic growth hormone treatment in normal rats reduces post-prandial skeletal muscle plasma membrane GLUT1 content, but not glucose transport or GLUT4 expression and localization. 
  • DRAGON: a member of the repulsive guidance molecule-related family of neuronal- and muscle-expressed membrane proteins is regulated by DRG11 and has neuronal adhesive properties. 
  • Deficiency of α-actinin-3 is associated with increased susceptibility to contraction-induced damage and skeletal muscle remodeling. 
  • Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle. 
  • Diagnosis of limb-girdle muscular dystrophy 2A by immunohistochemical techniques. 
  • Differences in muscle protein synthesis and anabolic signaling in the postabsorptive state and in response to food in 65-80 year old men and women. 
  • Different obscurin isoforms localize to distinct sites at sarcomeres. 
  • Differentiation- and stress-dependent nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling protein. 
  • Drosophila stretchin-MLCK is a novel member of the Titin/Myosin light chain kinase family. 
  • Dual Ser and Thr phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by MYPT-associated kinase. 
  • Dual roles of modulatory calcineurin-interacting protein 1 in cardiac hypertrophy. 
  • Dynamic regulation of sarcoplasmic reticulum Ca(2+) stores by stromal interaction molecule 1 and sarcolipin during muscle differentiation. 
  • Dysferlin, annexin A1, and mitsugumin 53 are upregulated in muscular dystrophy and localize to longitudinal tubules of the T-system with stretch. 
  • E1A-mediated inhibition of myogenesis correlates with a direct physical interaction of E1A12S and basic helix-loop-helix proteins. 
  • EAA supplementation to increase nitrogen intake improves muscle function during bed rest in the elderly. 
  • Early de novo DNA methylation and prolonged demethylation in the muscle lineage. 
  • Ectopic expression of Hel-N1, an RNA-binding protein, increases glucose transporter (GLUT1) expression in 3T3-L1 adipocytes. 
  • Ectopic lipid deposition and the metabolic profile of skeletal muscle in ovariectomized mice. 
  • Effect of 10 days of bed rest on skeletal muscle in healthy older adults. 
  • Effect of ibuprofen and acetaminophen on postexercise muscle protein synthesis. 
  • Effect of nandrolone decanoate administration on recovery from bupivacaine-induced muscle injury. 
  • Effects of Fortetropin on the Rate of Muscle Protein Synthesis in Older Men and Women: A Randomized, Double-Blinded, Placebo-Controlled Study. 
  • Effects of inhibition of mitochondrial protein synthesis in skeletal muscle. 
  • Electrophysiological basis and genetics of Brugada syndrome. 
  • Endothelial cell junctions and the regulation of vascular permeability and leukocyte transmigration. 
  • Endothelin-1 induces an increase in total protein synthesis and expression of the smooth muscle alpha-actin gene in vascular smooth muscle cells. 
  • Engineered bacterial voltage-gated sodium channel platform for cardiac gene therapy. 
  • Epigenome-Wide Association Study for All-Cause Mortality in a Cardiovascular Cohort Identifies Differential Methylation in Castor Zinc Finger 1 (CASZ1). 
  • Exercise increases muscle GLUT-4 levels and insulin action in subjects with impaired glucose tolerance. 
  • Exercise training increases electron and substrate shuttling proteins in muscle of overweight men and women with the metabolic syndrome. 
  • Exercise, nutrition and aging. 
  • Familial X-linked myalgia and cramps: a nonprogressive myopathy associated with a deletion in the dystrophin gene. 
  • G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy. 
  • Gene-gene Interaction Analyses for Atrial Fibrillation. 
  • Genetic Investigation Into the Differential Risk of Atrial Fibrillation Among Black and White Individuals. 
  • Genetic variants in Hippo pathway genes YAP1, TEAD1 and TEAD4 are associated with melanoma-specific survival. 
  • Genetics of Human Longevity From Incomplete Data: New Findings From the Long Life Family Study. 
  • Genome-Wide Association Study to Identify Susceptibility Loci That Modify Radiation-Related Risk for Breast Cancer After Childhood Cancer. 
  • Genome-wide association studies of the PR interval in African Americans. 
  • High-affinity [3H]PN200-110 and [3H]ryanodine binding to rabbit and frog skeletal muscle. 
  • High-intensity interval training and essential amino acid supplementation: Effects on muscle characteristics and whole-body protein turnover. 
  • Hysteresis in human HCN4 channels: a crucial feature potentially affecting sinoatrial node pacemaking. 
  • Identification of the cardiac beta-adrenergic receptor protein: solubilization and purification by affinity chromatography. 
  • Immunocompetent murine model of cancer cachexia for head and neck squamous cell carcinoma. 
  • Increased expression of fibroblast growth factors in a rabbit skeletal muscle model of exercise conditioning. 
  • Increased glucose disposal induced by adenovirus-mediated transfer of glucokinase to skeletal muscle in vivo. 
  • Independent signals control expression of the calcineurin inhibitory proteins MCIP1 and MCIP2 in striated muscles. 
  • Inherited deletion at Duchenne dystrophy locus in normal male. 
  • Insulin and glucosamine infusions increase O-linked N-acetyl-glucosamine in skeletal muscle proteins in vivo. 
  • Integrating genetic, transcriptional, and functional analyses to identify 5 novel genes for atrial fibrillation. 
  • Interactions between dystrophin and the sarcolemma membrane. 
  • Intravenous allopurinol decreases myocardial oxygen consumption and increases mechanical efficiency in dogs with pacing-induced heart failure. 
  • Intrinsic myocyte dysfunction and tyrosine kinase pathway activation underlie the impaired wall thickening of adjacent regions during postinfarct left ventricular remodeling. 
  • Isolation of a rat parvalbumin gene and full length cDNA. 
  • Longitudinal variation in muscle protein expression and contraction kinetics of largemouth bass axial muscle. 
  • Lumenal sites and C terminus accessibility of the skeletal muscle calcium release channel (ryanodine receptor). 
  • MECHANISM OF ENZYME CATALYSIS. 
  • Macromolecular levels, DNA synthesis and ornithine decarboxylase activity in leg muscles from 6-mercaptopurine-treated rats. 
  • Mechanical and chemical unfolding of a single protein: a comparison. 
  • Mechanical unfolding intermediates in titin modules. 
  • Mechanical unfolding of an ankyrin repeat protein. 
  • Mechanisms by which smoothelin-like protein 1 reverses insulin resistance in myotubules and mice. 
  • Metabolism: A is for adipokine. 
  • Modulation of smooth muscle contractility by CHASM, a novel member of the smoothelin family of proteins. 
  • MuRF2 regulates PPARγ1 activity to protect against diabetic cardiomyopathy and enhance weight gain induced by a high fat diet. 
  • Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity. 
  • Multiple conformations of PEVK proteins detected by single-molecule techniques. 
  • Multiple domains of MCIP1 contribute to inhibition of calcineurin activity. 
  • Multiple structural elements define the specificity of recombinant human inhibitor-1 as a protein phosphatase-1 inhibitor. 
  • Muscle damage: nutritional considerations. 
  • Muscle giants: molecular scaffolds in sarcomerogenesis. 
  • Muscle protein changes following eccentric exercise in humans. 
  • Muscle ring finger-3 protects against diabetic cardiomyopathy induced by a high fat diet. 
  • Muscle wasting and interleukin-6-induced atrogin-I expression in the cachectic Apc ( Min/+ ) mouse. 
  • Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I. 
  • Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humans. 
  • MyoD, modularity, and myogenesis: conservation of regulators and redundancy in C. elegans. 
  • Myocyte-enriched calcineurin-interacting protein, MCIP1, inhibits cardiac hypertrophy in vivo. 
  • Myogenic stem cell function is impaired in mice lacking the forkhead/winged helix protein MNF. 
  • Myoid differentiation and prognosis in adult pleomorphic sarcomas of the extremity: an analysis of 92 cases. 
  • Myotilin is mutated in limb girdle muscular dystrophy 1A. 
  • Myotilin is not the causative gene for vocal cord and pharyngeal weakness with distal myopathy (VCPDM). 
  • Myotilin overexpression enhances myopathology in the LGMD1A mouse model. 
  • NDRG4 is required for cell cycle progression and survival in glioblastoma cells. 
  • Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytes. 
  • New member of the trefoil factor family of proteins is an alpha-macroglobulin protease inhibitor. 
  • Nitric oxide regulation of myocardial contractility and calcium cycling: independent impact of neuronal and endothelial nitric oxide synthases. 
  • Novel Genetic Triggers and Genotype-Phenotype Correlations in Patients With Left Ventricular Noncompaction. 
  • Obscurin interacts with a novel isoform of MyBP-C slow at the periphery of the sarcomeric M-band and regulates thick filament assembly. 
  • Overexpression of TNNI3K, a cardiac-specific MAPKKK, promotes cardiac dysfunction. 
  • Overexpression of protein targeting to glycogen in cultured human muscle cells stimulates glycogen synthesis independent of glycogen and glucose 6-phosphate levels. 
  • Overexpression of the cardiac beta(2)-adrenergic receptor and expression of a beta-adrenergic receptor kinase-1 (betaARK1) inhibitor both increase myocardial contractility but have differential effects on susceptibility to ischemic injury. 
  • Oxidative phenotype protects myofibers from pathological insults induced by chronic heart failure in mice. 
  • Persistent expression of MNF identifies myogenic stem cells in postnatal muscles. 
  • Phosphorylation of telokin by cyclic nucleotide kinases and the identification of in vivo phosphorylation sites in smooth muscle. 
  • Podocyte cell cycle regulation and proliferation in collapsing glomerulopathies. 
  • Point mutations alter the mechanical stability of immunoglobulin modules. 
  • Pregnancy and Smoothelin-like Protein 1 (SMTNL1) Deletion Promote the Switching of Skeletal Muscle to a Glycolytic Phenotype in Human and Mice. 
  • Protein kinase-zeta interacts with munc18c: role in GLUT4 trafficking. 
  • Proteome-wide muscle protein fractional synthesis rates predict muscle mass gain in response to a selective androgen receptor modulator in rats. 
  • RBFOX2 is critical for maintaining alternative polyadenylation patterns and mitochondrial health in rat myoblasts. 
  • Recent advances for measurement of protein synthesis rates, use of the 'Virtual Biopsy' approach, and measurement of muscle mass. 
  • Reduced Oxidative Phosphorylation and Increased Glycolysis in Human Glaucoma Lamina Cribrosa Cells. 
  • Reduced junctional Na+/Ca2+-exchanger activity contributes to sarcoplasmic reticulum Ca2+ leak in junctophilin-2-deficient mice. 
  • Regional absence of mitochondria causing energy depletion in the myocardium of muscle LIM protein knockout mice. 
  • Regulation of myocardial betaARK1 expression in catecholamine-induced cardiac hypertrophy in transgenic mice overexpressing alpha1B-adrenergic receptors. 
  • Regulation of myosin light chain phosphorylation in the trabecular meshwork: role in aqueous humour outflow facility. 
  • Regulation of rat heart ornithine decarboxylase: change in affinity for ornithine evoked by neuronal, hormonal, and ontogenetic stimuli. 
  • Regulatory and structural motifs of chicken gizzard myosin light chain kinase. 
  • Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin. 
  • Reverse actin sliding triggers strong myosin binding that moves tropomyosin. 
  • Reverse engineering of the giant muscle protein titin. 
  • Reversible unfolding of fibronectin type III and immunoglobulin domains provides the structural basis for stretch and elasticity of titin and fibronectin. 
  • S-Nitrosylation of Sarcomeric Proteins Depresses Myofilament Ca2+)Sensitivity in Intact Cardiomyocytes. 
  • Sarcopenia, weight loss, and nutritional frailty in the elderly. 
  • Screen and identification of proteins interacting with ADAM19 cytoplasmic tail. 
  • Sensing heart stress. 
  • Sex-specific genetic predictors of Alzheimer's disease biomarkers. 
  • Single molecular force spectroscopy of modular proteins in the nervous system. 
  • Single protein misfolding events captured by atomic force microscopy. 
  • Single-target molecule detection with nonbleaching multicolor optical immunolabels. 
  • Site-specific phosphorylation and point mutations of telokin modulate its Ca2+-desensitizing effect in smooth muscle. 
  • Sites of interaction between kinase-related protein and smooth muscle myosin. 
  • Skeletal muscle adaptation to chronic low-frequency motor nerve stimulation. 
  • Skeletal muscle dictates the fibrinolytic state after exercise training in overweight men with characteristics of metabolic syndrome. 
  • Skeletal muscle loss: cachexia, sarcopenia, and inactivity. 
  • Skeletal muscle protein synthesis and the abundance of the mRNA translation initiation repressor PDCD4 are inversely regulated by fasting and refeeding in rats. 
  • Slow sodium channel inactivation and use-dependent block modulated by the same domain IV S6 residue. 
  • Smoothelin-like 1 deletion enhances myogenic reactivity of mesenteric arteries with alterations in PKC and myosin phosphatase signaling. 
  • Smoothelin-like 1 protein is a bifunctional regulator of the progesterone receptor during pregnancy. 
  • Smoothelin-like 1 protein regulates myosin phosphatase-targeting subunit 1 expression during sexual development and pregnancy. 
  • Sodium channel kinetic changes that produce Brugada syndrome or progressive cardiac conduction system disease. 
  • Specific binding sites for atrial natriuretic factor in the human kidney. 
  • Starch Binding Domain-containing Protein 1 Plays a Dominant Role in Glycogen Transport to Lysosomes in Liver. 
  • Stbd1 is highly elevated in skeletal muscle of Pompe disease mice but suppression of its expression does not affect lysosomal glycogen accumulation. 
  • Stretching single protein molecules: titin is a weird spring. 
  • Structural organization and chromosomal assignment of the parvalbumin gene. 
  • Syncoilin isoform organization and differential expression in murine striated muscle. 
  • Syncoilin modulates peripherin filament networks and is necessary for large-calibre motor neurons. 
  • Synthetic atrial natriuretic factor decreases renal tubular phosphate reabsorption in rats. 
  • T-tubule depolarization-induced SR Ca2+ release is controlled by dihydropyridine receptor- and Ca(2+)-dependent mechanisms in cell homogenates from rabbit skeletal muscle. 
  • TRPC3 channels confer cellular memory of recent neuromuscular activity. 
  • Temperature-sensitive mutations in the III-IV cytoplasmic loop region of the skeletal muscle sodium channel gene in paramyotonia congenita. 
  • The Ca2+-binding protein parvalbumin: molecular cloning and developmental regulation of mRNA abundance. 
  • The HO-1/CO system regulates mitochondrial-capillary density relationships in human skeletal muscle. 
  • The KASH domain protein MSP-300 plays an essential role in nuclear anchoring during Drosophila oogenesis. 
  • The basketweave form of the Z-band is expanded relative to the small-square form. 
  • The clash in titin. 
  • The junctophilin family of proteins: from bench to bedside. 
  • The myoD gene family: nodal point during specification of the muscle cell lineage. 
  • The posterior cricoarytenoid muscle is spared from MuRF1-mediated muscle atrophy in mice with acute lung injury. 
  • The presence of parvalbumin in a nonmuscle cell line attenuates progression through mitosis. 
  • The regulation of skeletal muscle protein turnover during the progression of cancer cachexia in the Apc(Min/+) mouse. 
  • The rho-guanine nucleotide exchange factor domain of obscurin activates rhoA signaling in skeletal muscle. 
  • The rho-guanine nucleotide exchange factor domain of obscurin regulates assembly of titin at the Z-disk through interactions with Ran binding protein 9. 
  • The role of calcium-independent phospholipase A2γ in modulation of aqueous humor drainage and Ca2+ sensitization of trabecular meshwork contraction. 
  • The role of diacylglycerol kinase ζ and phosphatidic acid in the mechanical activation of mammalian target of rapamycin (mTOR) signaling and skeletal muscle hypertrophy. 
  • The role of modulatory calcineurin-interacting proteins in calcineurin signaling. 
  • The role of the calponin homology domain of smoothelin-like 1 (SMTNL1) in myosin phosphatase inhibition and smooth muscle contraction. 
  • The structure and evolution of parvalbumins. I. Amino acid compositional studies of parvalbumins from four perciform species. 
  • The ubiquitin ligase MuRF1 regulates PPARα activity in the heart by enhancing nuclear export via monoubiquitination. 
  • The whole-genome landscape of medulloblastoma subtypes. 
  • Tissue-engineered 3-dimensional (3D) microenvironment enhances the direct reprogramming of fibroblasts into cardiomyocytes by microRNAs. 
  • Titin and nebulin content in human skeletal muscle following eccentric resistance exercise. 
  • Transcription factors MYOCD, SRF, Mesp1 and SMARCD3 enhance the cardio-inducing effect of GATA4, TBX5, and MEF2C during direct cellular reprogramming. 
  • Transdifferentiation of human endothelial progenitors into smooth muscle cells. 
  • Transgelin-2 as a therapeutic target for asthmatic pulmonary resistance. 
  • Transgelin-2: Biochemical and Clinical Implications in Cancer and Asthma. 
  • Transgenic mice expressing the myotilin T57I mutation unite the pathology associated with LGMD1A and MFM. 
  • beta -Arrestin-mediated recruitment of the Src family kinase Yes mediates endothelin-1-stimulated glucose transport. 
  • myotilin Mutation found in second pedigree with LGMD1A. 
  • p53-dependent induction of heat shock protein 27 (HSP27) expression. 
  • α1-Syntrophin Variant Identified in Drug-Induced Long QT Syndrome Increases Late Sodium Current. 
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  Keywords of People

  • Erickson, Harold Paul, James B. Duke Distinguished Professor of Cell Biology, Cell Biology
  • Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology
  • Starmer, Charles Franklin, Professor Emeritus of Computer Science, Computer Science
  • Zhong, Xiaoping, Professor of Pediatrics, Immunology