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Subject Areas on Research
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4-Aminopyridine attenuates muscle atrophy after sciatic nerve crush injury in mice.
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A common SCN5A polymorphism attenuates a severe cardiac phenotype caused by a nonsense SCN5A mutation in a Chinese family with an inherited cardiac conduction defect.
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A defect in myoblast fusion underlies Carey-Fineman-Ziter syndrome.
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A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling.
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Acceleration of myosin light chain dephosphorylation and relaxation of smooth muscle by telokin. Synergism with cyclic nucleotide-activated kinase.
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Accessory subunit KChIP2 modulates the cardiac L-type calcium current.
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Active involvement of PKC for insulin-mediated rates of muscle protein synthesis in Zucker rats.
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Acute interleukin-6 administration does not impair muscle glucose uptake or whole-body glucose disposal in healthy humans.
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Adaptive Activation of a Stress Response Pathway Improves Learning and Memory Through Gs and β-Arrestin-1-Regulated Lactate Metabolism.
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Administration of atrial natriuretic factor inhibits sodium-coupled transport in proximal tubules.
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Akt signalling through GSK-3beta, mTOR and Foxo1 is involved in human skeletal muscle hypertrophy and atrophy.
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Alpha-2 macroglobulin in Alzheimer's disease: a marker of neuronal injury through the RCAN1 pathway.
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Altered stored calcium release in skeletal myotubes deficient of triadin and junctin.
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An epilepsy/dyskinesia-associated mutation enhances BK channel activation by potentiating Ca2+ sensing.
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An increase in the myocardial PCr/ATP ratio in GLUT4 null mice.
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Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma.
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Analysis of enriched rare variants in JPH2-encoded junctophilin-2 among Greater Middle Eastern individuals reveals a novel homozygous variant associated with neonatal dilated cardiomyopathy.
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Antibodies in sera of patients with late-onset myasthenia gravis recognize the PEVK domain of titin.
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Assembly of the dystrophin-associated protein complex does not require the dystrophin COOH-terminal domain.
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Association of genetic variants of FBXO32 and FOXO6 in the FOXO pathway with breast cancer risk.
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Atomic force microscopy captures length phenotypes in single proteins.
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Atrial chamber-specific expression of sarcolipin is regulated during development and hypertrophic remodeling.
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Being there: cellular targeting of voltage-gated sodium channels in the heart.
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Biochemical comparison of fast- and slow-contracting squid muscle.
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Biological cross-reactivity of rat testis phosphodiesterase activator protein and rabbit skeletal muscle troponin-C.
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Ca2+-dependent regulation of cyclic-AMP phosphodiesterase by parvalbumin.
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Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites.
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Calcium control of muscle phosphorylase kinase through the combined action of calmodulin and troponin.
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Calcium-dependent gene regulation in myocyte hypertrophy and remodeling.
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Cardiac micro-computed tomography for morphological and functional phenotyping of muscle LIM protein null mice.
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Cardiac tissue engineering: cell seeding, cultivation parameters, and tissue construct characterization.
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Cardiac-specific LIM protein FHL2 modifies the hypertrophic response to beta-adrenergic stimulation.
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Cellular and functional defects in a mouse model of heart failure.
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Chronic growth hormone treatment in normal rats reduces post-prandial skeletal muscle plasma membrane GLUT1 content, but not glucose transport or GLUT4 expression and localization.
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Control of muscle formation by the fusogenic micropeptide myomixer.
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DRAGON: a member of the repulsive guidance molecule-related family of neuronal- and muscle-expressed membrane proteins is regulated by DRG11 and has neuronal adhesive properties.
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Deficiency of α-actinin-3 is associated with increased susceptibility to contraction-induced damage and skeletal muscle remodeling.
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Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle.
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Diagnosis of limb-girdle muscular dystrophy 2A by immunohistochemical techniques.
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Differences in muscle protein synthesis and anabolic signaling in the postabsorptive state and in response to food in 65-80 year old men and women.
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Different obscurin isoforms localize to distinct sites at sarcomeres.
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Differentiation- and stress-dependent nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling protein.
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Drosophila stretchin-MLCK is a novel member of the Titin/Myosin light chain kinase family.
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Dual Ser and Thr phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by MYPT-associated kinase.
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Dual roles of modulatory calcineurin-interacting protein 1 in cardiac hypertrophy.
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Dynamic regulation of sarcoplasmic reticulum Ca(2+) stores by stromal interaction molecule 1 and sarcolipin during muscle differentiation.
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Dysferlin, annexin A1, and mitsugumin 53 are upregulated in muscular dystrophy and localize to longitudinal tubules of the T-system with stretch.
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E1A-mediated inhibition of myogenesis correlates with a direct physical interaction of E1A12S and basic helix-loop-helix proteins.
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EAA supplementation to increase nitrogen intake improves muscle function during bed rest in the elderly.
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Early de novo DNA methylation and prolonged demethylation in the muscle lineage.
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Ectopic expression of Hel-N1, an RNA-binding protein, increases glucose transporter (GLUT1) expression in 3T3-L1 adipocytes.
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Ectopic lipid deposition and the metabolic profile of skeletal muscle in ovariectomized mice.
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Effect of 10 days of bed rest on skeletal muscle in healthy older adults.
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Effect of ibuprofen and acetaminophen on postexercise muscle protein synthesis.
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Effect of nandrolone decanoate administration on recovery from bupivacaine-induced muscle injury.
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Effects of Fortetropin on the Rate of Muscle Protein Synthesis in Older Men and Women: A Randomized, Double-Blinded, Placebo-Controlled Study.
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Effects of inhibition of mitochondrial protein synthesis in skeletal muscle.
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Electrophysiological basis and genetics of Brugada syndrome.
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Endothelial cell junctions and the regulation of vascular permeability and leukocyte transmigration.
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Endothelin-1 induces an increase in total protein synthesis and expression of the smooth muscle alpha-actin gene in vascular smooth muscle cells.
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Engineered bacterial voltage-gated sodium channel platform for cardiac gene therapy.
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Epigenome-Wide Association Study for All-Cause Mortality in a Cardiovascular Cohort Identifies Differential Methylation in Castor Zinc Finger 1 (CASZ1).
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Exercise increases muscle GLUT-4 levels and insulin action in subjects with impaired glucose tolerance.
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Exercise training increases electron and substrate shuttling proteins in muscle of overweight men and women with the metabolic syndrome.
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Exercise, nutrition and aging.
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Failure of human rhombic lip differentiation underlies medulloblastoma formation.
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Familial X-linked myalgia and cramps: a nonprogressive myopathy associated with a deletion in the dystrophin gene.
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G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy.
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Gene-gene Interaction Analyses for Atrial Fibrillation.
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Genetic Investigation Into the Differential Risk of Atrial Fibrillation Among Black and White Individuals.
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Genetic variants in Hippo pathway genes YAP1, TEAD1 and TEAD4 are associated with melanoma-specific survival.
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Genetics of Human Longevity From Incomplete Data: New Findings From the Long Life Family Study.
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Genome-Wide Association Study to Identify Susceptibility Loci That Modify Radiation-Related Risk for Breast Cancer After Childhood Cancer.
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Genome-wide association studies of the PR interval in African Americans.
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High-affinity [3H]PN200-110 and [3H]ryanodine binding to rabbit and frog skeletal muscle.
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High-intensity interval training and essential amino acid supplementation: Effects on muscle characteristics and whole-body protein turnover.
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Hysteresis in human HCN4 channels: a crucial feature potentially affecting sinoatrial node pacemaking.
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Identification of the cardiac beta-adrenergic receptor protein: solubilization and purification by affinity chromatography.
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Immunocompetent murine model of cancer cachexia for head and neck squamous cell carcinoma.
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Increased expression of fibroblast growth factors in a rabbit skeletal muscle model of exercise conditioning.
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Increased glucose disposal induced by adenovirus-mediated transfer of glucokinase to skeletal muscle in vivo.
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Independent signals control expression of the calcineurin inhibitory proteins MCIP1 and MCIP2 in striated muscles.
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Inherited deletion at Duchenne dystrophy locus in normal male.
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Insulin and glucosamine infusions increase O-linked N-acetyl-glucosamine in skeletal muscle proteins in vivo.
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Integrating genetic, transcriptional, and functional analyses to identify 5 novel genes for atrial fibrillation.
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Interactions between dystrophin and the sarcolemma membrane.
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Intravenous allopurinol decreases myocardial oxygen consumption and increases mechanical efficiency in dogs with pacing-induced heart failure.
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Intrinsic myocyte dysfunction and tyrosine kinase pathway activation underlie the impaired wall thickening of adjacent regions during postinfarct left ventricular remodeling.
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Isolation of a rat parvalbumin gene and full length cDNA.
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Longitudinal variation in muscle protein expression and contraction kinetics of largemouth bass axial muscle.
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Lumenal sites and C terminus accessibility of the skeletal muscle calcium release channel (ryanodine receptor).
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MECHANISM OF ENZYME CATALYSIS.
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Macromolecular levels, DNA synthesis and ornithine decarboxylase activity in leg muscles from 6-mercaptopurine-treated rats.
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Mechanical and chemical unfolding of a single protein: a comparison.
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Mechanical unfolding intermediates in titin modules.
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Mechanical unfolding of an ankyrin repeat protein.
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Mechanisms by which smoothelin-like protein 1 reverses insulin resistance in myotubules and mice.
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Metabolism: A is for adipokine.
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Modulation of smooth muscle contractility by CHASM, a novel member of the smoothelin family of proteins.
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MuRF2 regulates PPARγ1 activity to protect against diabetic cardiomyopathy and enhance weight gain induced by a high fat diet.
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Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity.
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Multiple conformations of PEVK proteins detected by single-molecule techniques.
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Multiple domains of MCIP1 contribute to inhibition of calcineurin activity.
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Multiple structural elements define the specificity of recombinant human inhibitor-1 as a protein phosphatase-1 inhibitor.
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Muscle damage: nutritional considerations.
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Muscle giants: molecular scaffolds in sarcomerogenesis.
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Muscle glycogen content and glucose uptake during exercise in humans: influence of prior exercise and dietary manipulation.
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Muscle protein changes following eccentric exercise in humans.
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Muscle ring finger-3 protects against diabetic cardiomyopathy induced by a high fat diet.
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Muscle wasting and interleukin-6-induced atrogin-I expression in the cachectic Apc ( Min/+ ) mouse.
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Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I.
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Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humans.
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MyoD, modularity, and myogenesis: conservation of regulators and redundancy in C. elegans.
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Myocyte-enriched calcineurin-interacting protein, MCIP1, inhibits cardiac hypertrophy in vivo.
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Myogenic stem cell function is impaired in mice lacking the forkhead/winged helix protein MNF.
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Myoid differentiation and prognosis in adult pleomorphic sarcomas of the extremity: an analysis of 92 cases.
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Myotilin is mutated in limb girdle muscular dystrophy 1A.
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Myotilin is not the causative gene for vocal cord and pharyngeal weakness with distal myopathy (VCPDM).
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Myotilin overexpression enhances myopathology in the LGMD1A mouse model.
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NDRG4 is required for cell cycle progression and survival in glioblastoma cells.
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Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytes.
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New member of the trefoil factor family of proteins is an alpha-macroglobulin protease inhibitor.
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Nitric oxide regulation of myocardial contractility and calcium cycling: independent impact of neuronal and endothelial nitric oxide synthases.
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Novel Genetic Triggers and Genotype-Phenotype Correlations in Patients With Left Ventricular Noncompaction.
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Obscurin interacts with a novel isoform of MyBP-C slow at the periphery of the sarcomeric M-band and regulates thick filament assembly.
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Overexpression of TNNI3K, a cardiac-specific MAPKKK, promotes cardiac dysfunction.
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Overexpression of protein targeting to glycogen in cultured human muscle cells stimulates glycogen synthesis independent of glycogen and glucose 6-phosphate levels.
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Overexpression of the cardiac beta(2)-adrenergic receptor and expression of a beta-adrenergic receptor kinase-1 (betaARK1) inhibitor both increase myocardial contractility but have differential effects on susceptibility to ischemic injury.
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Oxidative phenotype protects myofibers from pathological insults induced by chronic heart failure in mice.
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PGC1-α over-expression prevents metabolic alterations and soleus muscle atrophy in hindlimb unloaded mice.
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Persistent expression of MNF identifies myogenic stem cells in postnatal muscles.
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Phosphoproteomic mapping reveals distinct signaling actions and activation of muscle protein synthesis by Isthmin-1.
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Phosphorylation of telokin by cyclic nucleotide kinases and the identification of in vivo phosphorylation sites in smooth muscle.
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Podocyte cell cycle regulation and proliferation in collapsing glomerulopathies.
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Point mutations alter the mechanical stability of immunoglobulin modules.
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Post-translational regulation of calsarcin-1 during pressure overload-induced cardiac hypertrophy.
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Pregnancy and Smoothelin-like Protein 1 (SMTNL1) Deletion Promote the Switching of Skeletal Muscle to a Glycolytic Phenotype in Human and Mice.
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Protein kinase-zeta interacts with munc18c: role in GLUT4 trafficking.
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Protein kinetic signatures of the remodeling heart following isoproterenol stimulation.
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Proteome-wide muscle protein fractional synthesis rates predict muscle mass gain in response to a selective androgen receptor modulator in rats.
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RBFOX2 is critical for maintaining alternative polyadenylation patterns and mitochondrial health in rat myoblasts.
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RBFox2-miR-34a-Jph2 axis contributes to cardiac decompensation during heart failure.
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Recent advances for measurement of protein synthesis rates, use of the 'Virtual Biopsy' approach, and measurement of muscle mass.
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Reduced Oxidative Phosphorylation and Increased Glycolysis in Human Glaucoma Lamina Cribrosa Cells.
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Reduced junctional Na+/Ca2+-exchanger activity contributes to sarcoplasmic reticulum Ca2+ leak in junctophilin-2-deficient mice.
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Regional absence of mitochondria causing energy depletion in the myocardium of muscle LIM protein knockout mice.
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Regulation of myocardial betaARK1 expression in catecholamine-induced cardiac hypertrophy in transgenic mice overexpressing alpha1B-adrenergic receptors.
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Regulation of myosin light chain phosphorylation in the trabecular meshwork: role in aqueous humour outflow facility.
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Regulation of rat heart ornithine decarboxylase: change in affinity for ornithine evoked by neuronal, hormonal, and ontogenetic stimuli.
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Regulator of Calcineurin 1 helps coordinate whole-body metabolism and thermogenesis.
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Regulatory and structural motifs of chicken gizzard myosin light chain kinase.
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Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin.
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Reverse actin sliding triggers strong myosin binding that moves tropomyosin.
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Reverse engineering of the giant muscle protein titin.
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Reversible unfolding of fibronectin type III and immunoglobulin domains provides the structural basis for stretch and elasticity of titin and fibronectin.
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S-Nitrosylation of Sarcomeric Proteins Depresses Myofilament Ca2+)Sensitivity in Intact Cardiomyocytes.
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Sarcopenia, weight loss, and nutritional frailty in the elderly.
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Screen and identification of proteins interacting with ADAM19 cytoplasmic tail.
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Sensing heart stress.
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Sex-specific genetic predictors of Alzheimer's disease biomarkers.
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Single molecular force spectroscopy of modular proteins in the nervous system.
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Single protein misfolding events captured by atomic force microscopy.
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Single-target molecule detection with nonbleaching multicolor optical immunolabels.
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Site-specific phosphorylation and point mutations of telokin modulate its Ca2+-desensitizing effect in smooth muscle.
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Sites of interaction between kinase-related protein and smooth muscle myosin.
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Skeletal muscle adaptation to chronic low-frequency motor nerve stimulation.
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Skeletal muscle dictates the fibrinolytic state after exercise training in overweight men with characteristics of metabolic syndrome.
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Skeletal muscle hemojuvelin is dispensable for systemic iron homeostasis.
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Skeletal muscle loss: cachexia, sarcopenia, and inactivity.
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Skeletal muscle protein synthesis and the abundance of the mRNA translation initiation repressor PDCD4 are inversely regulated by fasting and refeeding in rats.
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Slow sodium channel inactivation and use-dependent block modulated by the same domain IV S6 residue.
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Smoothelin-like 1 deletion enhances myogenic reactivity of mesenteric arteries with alterations in PKC and myosin phosphatase signaling.
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Smoothelin-like 1 protein is a bifunctional regulator of the progesterone receptor during pregnancy.
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Smoothelin-like 1 protein regulates myosin phosphatase-targeting subunit 1 expression during sexual development and pregnancy.
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Sodium channel kinetic changes that produce Brugada syndrome or progressive cardiac conduction system disease.
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Specific binding sites for atrial natriuretic factor in the human kidney.
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Starch Binding Domain-containing Protein 1 Plays a Dominant Role in Glycogen Transport to Lysosomes in Liver.
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Stbd1 is highly elevated in skeletal muscle of Pompe disease mice but suppression of its expression does not affect lysosomal glycogen accumulation.
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Stretching single protein molecules: titin is a weird spring.
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Structural organization and chromosomal assignment of the parvalbumin gene.
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Substrate availability and transcriptional regulation of metabolic genes in human skeletal muscle during recovery from exercise.
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Syncoilin isoform organization and differential expression in murine striated muscle.
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Syncoilin modulates peripherin filament networks and is necessary for large-calibre motor neurons.
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Synthetic atrial natriuretic factor decreases renal tubular phosphate reabsorption in rats.
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T-tubule depolarization-induced SR Ca2+ release is controlled by dihydropyridine receptor- and Ca(2+)-dependent mechanisms in cell homogenates from rabbit skeletal muscle.
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TRPC3 channels confer cellular memory of recent neuromuscular activity.
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Temperature-sensitive mutations in the III-IV cytoplasmic loop region of the skeletal muscle sodium channel gene in paramyotonia congenita.
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The Ca2+-binding protein parvalbumin: molecular cloning and developmental regulation of mRNA abundance.
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The Calcineurin-FoxO-MuRF1 signaling pathway regulates myofibril integrity in cardiomyocytes.
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The HO-1/CO system regulates mitochondrial-capillary density relationships in human skeletal muscle.
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The KASH domain protein MSP-300 plays an essential role in nuclear anchoring during Drosophila oogenesis.
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The basketweave form of the Z-band is expanded relative to the small-square form.
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The chromatin-binding protein Smyd1 restricts adult mammalian heart growth.
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The clash in titin.
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The junctophilin family of proteins: from bench to bedside.
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The myoD gene family: nodal point during specification of the muscle cell lineage.
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The posterior cricoarytenoid muscle is spared from MuRF1-mediated muscle atrophy in mice with acute lung injury.
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The presence of parvalbumin in a nonmuscle cell line attenuates progression through mitosis.
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The regulation of skeletal muscle protein turnover during the progression of cancer cachexia in the Apc(Min/+) mouse.
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The rho-guanine nucleotide exchange factor domain of obscurin activates rhoA signaling in skeletal muscle.
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The rho-guanine nucleotide exchange factor domain of obscurin regulates assembly of titin at the Z-disk through interactions with Ran binding protein 9.
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The role of calcium-independent phospholipase A2γ in modulation of aqueous humor drainage and Ca2+ sensitization of trabecular meshwork contraction.
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The role of diacylglycerol kinase ζ and phosphatidic acid in the mechanical activation of mammalian target of rapamycin (mTOR) signaling and skeletal muscle hypertrophy.
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The role of modulatory calcineurin-interacting proteins in calcineurin signaling.
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The role of the calponin homology domain of smoothelin-like 1 (SMTNL1) in myosin phosphatase inhibition and smooth muscle contraction.
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The structure and evolution of parvalbumins. I. Amino acid compositional studies of parvalbumins from four perciform species.
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The ubiquitin ligase MuRF1 regulates PPARα activity in the heart by enhancing nuclear export via monoubiquitination.
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The whole-genome landscape of medulloblastoma subtypes.
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Tissue-engineered 3-dimensional (3D) microenvironment enhances the direct reprogramming of fibroblasts into cardiomyocytes by microRNAs.
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Titin and nebulin content in human skeletal muscle following eccentric resistance exercise.
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Transcription factors MYOCD, SRF, Mesp1 and SMARCD3 enhance the cardio-inducing effect of GATA4, TBX5, and MEF2C during direct cellular reprogramming.
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Transdifferentiation of human endothelial progenitors into smooth muscle cells.
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Transgelin-2 as a therapeutic target for asthmatic pulmonary resistance.
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Transgelin-2: Biochemical and Clinical Implications in Cancer and Asthma.
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Transgenic mice expressing the myotilin T57I mutation unite the pathology associated with LGMD1A and MFM.
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beta -Arrestin-mediated recruitment of the Src family kinase Yes mediates endothelin-1-stimulated glucose transport.
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myotilin Mutation found in second pedigree with LGMD1A.
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p38-MAPK induced dephosphorylation of alpha-tropomyosin is associated with depression of myocardial sarcomeric tension and ATPase activity.
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p53-dependent induction of heat shock protein 27 (HSP27) expression.
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α1-Syntrophin Variant Identified in Drug-Induced Long QT Syndrome Increases Late Sodium Current.
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Keywords of People
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Erickson, Harold Paul,
Professor Emeritus of Cell Biology,
Cell Biology
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Pitt, Geoffrey Stuart,
Adjunct Professor in the Department of Medicine,
Medicine, Cardiology
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Starmer, Charles Franklin,
Professor Emeritus of Computer Science,
Computer Science
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Zhong, Xiaoping,
Professor of Pediatrics,
Immunology