Muscle, Smooth

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  Subject Areas on Research

  • (i, i + 4) Ion pairs stabilize helical peptides derived from smooth muscle caldesmon. 
  • A fixative for use in muscle histochemistry. 
  • A functional proteomics approach to signal transduction. 
  • A maturational model for the study of airway smooth muscle adaptation to mechanical oscillation. 
  • A model of neural cross-talk and irritation in the pelvis: implications for the overlap of chronic pelvic pain disorders. 
  • A role for sonic hedgehog signaling in the pathogenesis of human tracheoesophageal fistula. 
  • A urethral afferent mediated excitatory bladder reflex exists in humans. 
  • Acceleration of myosin light chain dephosphorylation and relaxation of smooth muscle by telokin. Synergism with cyclic nucleotide-activated kinase. 
  • Acquired cutaneous smooth muscle hamartoma. 
  • Activation of NAD(P)H oxidase by lipid hydroperoxides: mechanism of oxidant-mediated smooth muscle cytotoxicity. 
  • Aerosol transfer of bladder urothelial and smooth muscle cells onto demucosalized colonic segments for bladder augmentation: in vivo, long term, and functional pilot study. 
  • Airway contractility and remodeling: links to asthma symptoms. 
  • Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma. 
  • Airway smooth muscle relaxation is impaired in mice lacking the p47phox subunit of NAD(P)H oxidase. 
  • Airways smooth muscle: the next generation. 
  • Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1. 
  • Anatomic relationships of infracoccygeal sacropexy (posterior intravaginal slingplasty) trocar insertion. 
  • Angiotensin II induces c-fos expression in smooth muscle via transcriptional control. 
  • Angiotensin induces the urinary peristaltic machinery during the perinatal period. 
  • Apoptosis in the cervix of pregnant rats in association with cervical softening. 
  • Assessment of upper esophageal sphincter function on high-resolution manometry: identification of predictors of globus symptoms. 
  • Association of calmodulin and smooth muscle myosin light chain kinase: application of a label selection technique with trace acetylated calmodulin. 
  • Autoregulation of enzymes by pseudosubstrate prototopes: myosin light chain kinase. 
  • Beta-adrenergic receptors in hamster smooth muscle cells are transcriptionally regulated by glucocorticoids. 
  • Beta-adrenoceptor agonists stimulate endothelial nitric oxide synthase in rat urinary bladder urothelial cells. 
  • Beta-arrestins specifically constrain beta2-adrenergic receptor signaling and function in airway smooth muscle. 
  • Bimatoprost, prostamide activity, and conventional drainage. 
  • Bladder activation by selective stimulation of pudendal nerve afferents in the cat. 
  • Bronchial thermoplasty for severe asthma. 
  • Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. 
  • Calmodulin kinase II chimeras used to investigate the structural requirements for smooth muscle myosin light chain kinase autoinhibition and calmodulin-dependent activation. 
  • Calmodulin regulation of smooth-muscle myosin light-chain kinase. 
  • Cell migration through defined, synthetic ECM analogs. 
  • Cellular basis for bimatoprost effects on human conventional outflow. 
  • Characterization of cytoskeleton-enriched protein fraction of the trabecular meshwork and ciliary muscle cells. 
  • Characterization of the secondary structure of calmodulin in complex with a calmodulin-binding domain peptide. 
  • Cholesterol feeding reduces vascular endothelial growth factor signaling in rabbit corporal tissues. 
  • Cholinergic mechanisms involved with histamine hyperreactivity in immune rabbit airways challenged with ragweed antigen. 
  • Chronic high-fat diet decreased detrusor mitochondrial respiration and increased nerve-mediated contractions. 
  • Collagen changes in rat cervix in pregnancy--polarized light microscopic and electron microscopic studies. 
  • Control of colonic motility using electrical stimulation to modulate enteric neural activity. 
  • Cystometric properties of ileum and right colon after bladder augmentation, substitution or replacement. 
  • Dehydroepiandrosterone and analogs inhibit DNA binding of AP-1 and airway smooth muscle proliferation. 
  • Delineating signal transduction pathways in smooth muscle through focused proteomics. 
  • Detecting the onset of hyper-reflexive bladder contractions from the electrical activity of the pudendal nerve. 
  • Detection of neurogenic detrusor contractions from the activity of the external anal sphincter in cat and human. 
  • Developmental expression of neurokinin A and functional neurokinin-2 receptors in lung. 
  • Developmental expression of the glucose-dependent insulinotropic polypeptide gene in rat intestine. 
  • Developmental renin expression in mice with a defective renin-angiotensin system. 
  • Different ontogeny of rate of force generation and shortening velocity in guinea pig trachealis. 
  • Differential expression of substance P receptors in patients with Crohn's disease and ulcerative colitis. 
  • Differentiation- and stress-dependent nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling protein. 
  • Dilated cardiomyopathy in transgenic mice expressing a mutant A subunit of protein phosphatase 2A. 
  • Distribution of the SGLT1 Na+/glucose cotransporter and mRNA along the crypt-villus axis of rabbit small intestine. 
  • Domain organization of chicken gizzard myosin light chain kinase deduced from a cloned cDNA. 
  • Dupuytren's fibroblast contractility by sphingosine-1-phosphate is mediated through non-muscle myosin II. 
  • Dysphagia in the setting of left ventricular assist device hemolysis. 
  • Editorial: Selectivity in beta-adrenergic responses: clinical implications. 
  • Effect of cooling on the responsiveness of canine tracheal muscle. 
  • Effect of lidocaine on endothelin-1-mediated airway smooth muscle contraction in the rat trachea. 
  • Effect of maturational changes in myosin content and morphometry on airway smooth muscle contraction. 
  • Effect of substance P on neurally mediated contraction of rabbit airway smooth muscle. 
  • Effects of electroacupuncture on gastric motility and heart rate variability in conscious rats. 
  • Effects of sphingosine-1-phosphate and ceramide-1-phosphate on rat intestinal smooth muscle cells: implications for postoperative ileus. 
  • Electrical stimulation of the urethra evokes bladder contractions and emptying in spinal cord injury men: case studies. 
  • Emerging clinical applications of electrical stimulation: opportunities for restoration of function. 
  • Endomyometriosis ("Uterus-like mass") in an XY Male: Case Report With Molecular Confirmation and Literature Review. 
  • Erythrocyte membrane tropomyosin. Purification and properties. 
  • Erythromycin lacks colon prokinetic effect in children with functional gastrointestinal disorders: a retrospective study. 
  • Evidence for preferential adhesion of ovarian epithelial carcinoma cells to type I collagen mediated by the alpha2beta1 integrin. 
  • Exaggerated smooth muscle contraction segments on esophageal high-resolution manometry: prevalence and clinical relevance. 
  • Excitation-contraction coupling in airway smooth muscle. 
  • Expression and function of transforming growth factor-β isoforms and cognate receptors in the rat urinary bladder following cyclophosphamide-induced cystitis. 
  • Expression of airway contractile properties and acetylcholinesterase activity in swine. 
  • Extracellular Ca2+ mobilization in potential-dependent contraction of trachealis of maturing swine. 
  • Fluorescence linked enzyme chemoproteomic strategy for discovery of a potent and selective DAPK1 and ZIPK inhibitor. 
  • Frequency-dependent selection of reflexes by pudendal afferents in the cat. 
  • Functional consequences of truncating amino acid side chains located at a calmodulin-peptide interface. 
  • Functional domains of chicken gizzard myosin light chain kinase. 
  • Functional evaluation of the grafted wall with porcine-derived small intestinal submucosa (SIS) to a stomach defect in rats. 
  • G protein-coupled receptor kinase 5 regulates airway responses induced by muscarinic receptor activation. 
  • GPCRs and arrestins in airways: implications for asthma. 
  • Gene expression programs of human smooth muscle cells: tissue-specific differentiation and prognostic significance in breast cancers. 
  • Genetic deletion of the Tas2r143/Tas2r135/Tas2r126 cluster reveals that TAS2Rs may not mediate bitter tastant-induced bronchodilation. 
  • Genetic heterogeneity of Myc-induced mammary tumors reflecting diverse phenotypes including metastatic potential. 
  • Give Me Some Room to Breathe! Can Targeting SPHK2 Reduce Airway Smooth Muscle Thickening in Asthma? 
  • Glycogen accumulation in smooth muscle of a Pompe disease mouse model. 
  • Growing up and advancing in airway smooth muscle research. 
  • Heparanase and platelet factor-4 induce smooth muscle cell proliferation and migration via bFGF release from the ECM. 
  • Histochemical analyses of altered fetal lung development following single vs multiple courses of antenatal steroids. 
  • Homeostatic regulation of airway smooth muscle tone by catecholamine secretion in swine. 
  • Identification of amino acids essential for calmodulin binding and activation of smooth muscle myosin light chain kinase. 
  • Identification of the endogenous smooth muscle myosin phosphatase-associated kinase. 
  • Identification of the functionally relevant calmodulin binding site in smooth muscle caldesmon. 
  • IgA antibodies against reticulin and endomysium in the serum and gastrointestinal secretions of patients with dermatitis herpetiformis. 
  • Impact of prostatic radiation therapy on bladder contractility and innervation. 
  • Improved bladder emptying in urinary retention by electrical stimulation of pudendal afferents 
  • Increasing use of positron emission tomography among medicare beneficiaries undergoing radical cystectomy. 
  • Induction of angiogenic immediate early genes by activation of FP prostanoid receptors in cultured human ciliary smooth muscle cells. 
  • Inhibition of rat arterial smooth muscle cell proliferation by heparin. In vivo studies with anticoagulant and nonanticoagulant heparin. 
  • Interplay between Immune and Airway Smooth Muscle Cells in Obese Asthma. 
  • Intrasteric regulation of myosin light chain kinase: the pseudosubstrate prototope binds to the active site. 
  • Intraurethral stimulation evokes bladder responses via 2 distinct reflex pathways. 
  • Intravesical liposome administration--a novel treatment for hyperactive bladder in the rat. 
  • Intravesical protamine sulfate and potassium chloride as a model for bladder hyperactivity. 
  • Investigations into the role of sulfhydryl groups in the mechanism of action of the nitrates. 
  • Isoforms of alpha-actinin from cardiac, smooth, and skeletal muscle form polar arrays of actin filaments. 
  • Kegel exercises and childhood incontinence: a new role for an old treatment. 
  • Laparoscopic myotomy for achalasia: predictors of successful outcome after 200 cases. 
  • Length oscillation induces force potentiation in infant guinea pig airway smooth muscle. 
  • Lipopolysaccharide upregulates bradykinin 1 receptors in the isolated mouse bladder. 
  • Longitudinal assessment of hepatitis C fibrosis progression by collagen and smooth muscle actin morphometry in comparison to serum markers. 
  • Mammalian alpha 1-adrenergic receptor. Purification and characterization of the native receptor ligand binding subunit. 
  • Maturation of acetylcholinesterase expression in tracheal smooth muscle contraction. 
  • Maturation of guinea pig tracheal strip stiffness. 
  • Maturational changes in airway smooth muscle shortening and relaxation. Implications for asthma. 
  • Mechanism of substance P-induced bronchoconstriction in maturing rabbit. 
  • Mechanisms of airway smooth muscle relaxation during maturation. 
  • Mechanisms of reflex bladder activation by pudendal afferents. 
  • Mechanisms of substance P-induced contraction of rabbit airway smooth muscle. 
  • Meperidine: a critical review. 
  • Microvascular injury and blood-brain barrier leakage in Alzheimer's disease. 
  • Modification of surfaces with cell adhesion peptides alters extracellular matrix deposition. 
  • Modulation of smooth muscle contractility by CHASM, a novel member of the smoothelin family of proteins. 
  • Molecular analysis of calmodulin and smooth muscle myosin light chain kinase. 
  • Molecular cloning and functional expression of a recombinant 72.5 kDa fragment of the 110 kDa regulatory subunit of smooth muscle protein phosphatase 1M. 
  • Multiple pudendal sensory pathways reflexly modulate bladder and urethral activity in patients with spinal cord injury. 
  • Muscle-invasive transitional cell carcinoma of the renal pelvis visualized and biopsied via semirigid ureteroscopy. 
  • Myolipoma of the eyelid. 
  • Myosin light chain kinase structure function analysis using bacterial expression. 
  • Myotomy: follow-up study of 50 patients. 
  • NADPH oxidase promotes NF-kappaB activation and proliferation in human airway smooth muscle. 
  • Neural control of the urethra and development of pharmacotherapy for stress urinary incontinence. 
  • Neural control of urethral outlet activity in vivo: role of nitric oxide. 
  • Neural mechanism of acupuncture-induced gastric relaxations in rats. 
  • Neurochemical effects of chronic dietary and repeated high-level acute exposure to chlorpyrifos in rats. 
  • Neurokinin receptors mediating substance P-induced contraction in adult rabbit airways. 
  • Neurokinin subtype receptors mediating substance P contraction in immature rabbit airways. 
  • Neuromodulation mediated by neurokinin-1 subtype receptors in adult rabbit airways. 
  • Neurotransmitter identity doubt. 
  • Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle. 
  • Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. 
  • Nitric oxide is a potent relaxant of human and rabbit corpus cavernosum. 
  • OAB without an overactive bladder in the acute prostaglandin E2 rat model. 
  • Ocular and histologic findings in a series of children with infantile pompe disease treated with enzyme replacement therapy. 
  • On the terminology for describing the length-force relationship and its changes in airway smooth muscle. 
  • Ontogenesis of myosin light chain kinase mRNA and protein content in guinea pig tracheal smooth muscle. 
  • Ontogenesis of myosin light chain phosphorylation in guinea pig tracheal smooth muscle. 
  • Ontogenic expression of acetylcholinesterase activity in trachealis of young swine. 
  • Ontogeny of shortening velocity in porcine trachealis. 
  • Oxybutynin chloride in the management of idiopathic detrusor instability. 
  • Pentosan polysulfate decreases prostate smooth muscle proliferation and extracellular matrix turnover. 
  • Peripherally administered CRF stimulates colonic motility via central CRF receptors and vagal pathways in conscious rats. 
  • Phosphatase and tensin homologue on chromosome 10 (PTEN) directs prostaglandin E2-mediated fibroblast responses via regulation of E prostanoid 2 receptor expression. 
  • Phosphorylation of telokin by cyclic nucleotide kinases and the identification of in vivo phosphorylation sites in smooth muscle. 
  • Phosphorylation of the myosin phosphatase target subunit by integrin-linked kinase. 
  • Physiological mechanisms mediating enhanced force generation during development and immune sensitization. 
  • Platelet hyaluronidase-2: an enzyme that translocates to the surface upon activation to function in extracellular matrix degradation. 
  • Predictors of adequate lymph node dissection in patients with non-muscle invasive bladder cancer undergoing radical cystectomy and effect on survival. 
  • Proliferation and apoptosis of fibroblasts and smooth muscle cells in rat uterine cervix throughout gestation and the effect of the antiprogesterone onapristone. 
  • Proteolysis of smooth muscle myosin light chain kinase. Formation of inactive and calmodulin-independent fragments. 
  • Pudendal nerve stimulation evokes reflex bladder contractions in persons with chronic spinal cord injury. 
  • Pulmonary vein contraction before and after radiofrequency ablation for atrial fibrillation. 
  • Purification and characterization of the mammalian myosin light chain phosphatase holoenzyme. The differential effects of the holoenzyme and its subunits on smooth muscle. 
  • Quantification of beta adrenergic receptor subtypes in beta-arrestin knockout mouse airways. 
  • Quantitative analysis of macrophages and perisinusoidal cells in primary biliary cirrhosis. 
  • Quantitative electromyographic analysis of levator ani and external anal sphincter muscles of nulliparous women. 
  • ROCK1 phosphorylates and activates zipper-interacting protein kinase. 
  • Rapacuronium augments acetylcholine-induced bronchoconstriction via positive allosteric interactions at the M3 muscarinic receptor. 
  • Rapacuronium preferentially antagonizes the function of M2 versus M3 muscarinic receptors in guinea pig airway smooth muscle. 
  • Real-time in vivo proteomic identification of novel kinase substrates in smooth muscle. 
  • Real-time optical coherence tomography of the anterior segment at 1310 nm. 
  • Receptors, channels, and signalling in the urothelial sensory system in the bladder. 
  • Reduced spontaneous relaxation in immature guinea pig airway smooth muscle is associated with increased prostanoid release. 
  • Regions of the 110-kDa regulatory subunit M110 required for regulation of myosin-light-chain-phosphatase activity in smooth muscle. 
  • Regulation of P311 expression by Met-hepatocyte growth factor/scatter factor and the ubiquitin/proteasome system. 
  • Regulation of adrenergic receptor function by phosphorylation. I. Agonist-promoted desensitization and phosphorylation of alpha 1-adrenergic receptors coupled to inositol phospholipid metabolism in DDT1 MF-2 smooth muscle cells. 
  • Regulation of adrenergic receptor function by phosphorylation. II. Effects of agonist occupancy on phosphorylation of alpha 1- and beta 2-adrenergic receptors by protein kinase C and the cyclic AMP-dependent protein kinase. 
  • Regulation of smooth muscle myosin light chain kinase by calmodulin. 
  • Regulatory and structural motifs of chicken gizzard myosin light chain kinase. 
  • Regulatory functions of calmodulin. 
  • Relaxation of guinea pig trachealis during electrical field stimulation increases with age. 
  • Requirement for reactive oxygen species in serum-induced and platelet-derived growth factor-induced growth of airway smooth muscle. 
  • Restraint stress augments postprandial gastric contractions but impairs antropyloric coordination in conscious rats. 
  • Rho GTPase/Rho kinase inhibition as a novel target for the treatment of glaucoma. 
  • Rodent model of reproductive tract leiomyomata. Establishment and characterization of tumor-derived cell lines. 
  • Ryanodine receptors in muscarinic receptor-mediated bronchoconstriction. 
  • S100A8 protein attenuates airway hyperresponsiveness by suppressing the contraction of airway smooth muscle. 
  • Selective O-desulfation produces nonanticoagulant heparin that retains pharmacological activity in the lung. 
  • Selenium-binding protein-1 in smooth muscle cells is downregulated in a rhesus monkey model of chronic allograft nephropathy. 
  • Site-specific phosphorylation and point mutations of telokin modulate its Ca2+-desensitizing effect in smooth muscle. 
  • Sites of interaction between kinase-related protein and smooth muscle myosin. 
  • Smooth muscle angiotensin II type 1A receptor is required for abdominal aortic aneurysm formation induced by angiotensin II plus β-aminopropionitrile. 
  • Smooth muscle cell proliferation in the occluded rat carotid artery: lack of requirement for luminal platelets. 
  • Smooth muscle myosin phosphatase-associated kinase induces Ca2+ sensitization via myosin phosphatase inhibition. 
  • Smooth muscle phosphatase is regulated in vivo by exclusion of phosphorylation of threonine 696 of MYPT1 by phosphorylation of Serine 695 in response to cyclic nucleotides. 
  • Smoothelin-like 1 protein is a bifunctional regulator of the progesterone receptor during pregnancy. 
  • Smoothelin-like 1 protein regulates myosin phosphatase-targeting subunit 1 expression during sexual development and pregnancy. 
  • Somatostatin regulates duodenal cholecystokinin and somatostatin messenger RNA. 
  • Specific interaction of 3H-FSH with rat testis binding sites. 
  • Specificity of arrestin subtypes in regulating airway smooth muscle G protein-coupled receptor signaling and function. 
  • Staurosporine inhibition of zipper-interacting protein kinase contractile effects in gastrointestinal smooth muscle. 
  • Stimulation of the pelvic nerve increases bladder capacity in the PGE₂ cat model of overactive bladder. 
  • Stimulation of the pelvic nerve increases bladder capacity in the prostaglandin E₂ rat model of overactive bladder. 
  • Structure of the smooth muscle myosin light-chain kinase calmodulin-binding domain peptide bound to calmodulin. 
  • The ACTN3 R577X Polymorphism Is Associated with Cardiometabolic Fitness in Healthy Young Adults. 
  • The calmodulin binding domain of chicken smooth muscle myosin light chain kinase contains a pseudosubstrate sequence. 
  • The cxc chemokine cCAF stimulates differentiation of fibroblasts into myofibroblasts and accelerates wound closure. 
  • The effect of alpha1-adrenergic receptor antagonist tamsulosin (Flomax) on iris dilator smooth muscle anatomy. 
  • The effect of chlorothiazide on neurally mediated contraction of rabbit bronchial smooth muscle. 
  • The effects of neuromodulation in a novel obese-prone rat model of detrusor underactivity. 
  • The impact of Pompe disease on smooth muscle: a review. 
  • The normal anatomy of the pig tailed macaque (Macaca nemestrina) outflow apparatus with particular reference to the presence of smooth muscle. 
  • The regulation of the cGMP-binding cGMP phosphodiesterase by proteins that are immunologically related to gamma subunit of the photoreceptor cGMP phosphodiesterase. 
  • The relaxant effect of diazoxide on nongravid human myometrium in vivo. 
  • The role of STIM1 and SOCE in smooth muscle contractility. 
  • The role of Smad3 in mediating mouse hepatic stellate cell activation. 
  • The role of the calponin homology domain of smoothelin-like 1 (SMTNL1) in myosin phosphatase inhibition and smooth muscle contraction. 
  • The significantly reduced number of interstitial cells of Cajal in chagasic megacolon (CM) patients might contribute to the pathophysiology of CM. 
  • Three amino acid substitutions in domain I of calmodulin prevent the activation of chicken smooth muscle myosin light chain kinase. 
  • Three paradigms of airway smooth muscle hyperresponsiveness in young guinea pigs. 
  • Thromboxane A2 induces airway constriction through an M3 muscarinic acetylcholine receptor-dependent mechanism. 
  • Transient receptor potential vanilloid 4 inhibits mouse colonic motility by activating NO-dependent enteric neurotransmission. 
  • Triple negative breast cancer: outcome correlation with immunohistochemical detection of basal markers. 
  • Troponin T3 expression in skeletal and smooth muscle is required for growth and postnatal survival: characterization of Tnnt3(tm2a(KOMP)Wtsi) mice. 
  • Urethral afferent nerve activity affects the micturition reflex; implication for the relationship between stress incontinence and detrusor instability. 
  • Urethral dysfunction in diabetic rats. 
  • Value of subtracted bladder pressure measurement in routine urodynamics. 
  • Vasoactive intestinal peptide (VIP) receptors in the canine gastrointestinal tract. 
  • ZIP kinase, a key regulator of myosin protein phosphatase 1. 
  • [3H]Dihydroergocryptine binding to alpha adrenergic receptors in canine aortic membranes. 
  • cGMP signal termination. 
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  Keywords of People

  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • Milano, Carmelo Alessio, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Surgery, Cardiovascular and Thoracic Surgery
  • Nielsen, Karen Cristina, Associate Professor of Anesthesiology, Anesthesiology, Ambulatory
  • Preminger, Glenn Michael, James F. Glenn, M.D. Distinguished Professor of Urology, Surgery, Urology
  • Sunday, Mary Elizabeth Anne, Professor of Pathology, Cell Biology