Muscle, Smooth, Vascular

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  Subject Areas on Research

  • (-)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637): a novel ATP-sensitive potassium channel opener efficacious in suppressing urinary bladder contractions. I. In vitro characterization. 
  • 22Na+ and 86Rb+ transport in vascular smooth muscle of SHR, Wistar Kyoto, and Wistar rats. 
  • 8-hydroxy-2-(di-n-propylamino)tetralin-responsive 5-hydroxytryptamine4-like receptor expressed in bovine pulmonary artery smooth muscle cells. 
  • A Small Molecule Pyrazolo[3,4-d]Pyrimidinone Inhibitor of Zipper-Interacting Protein Kinase Suppresses Calcium Sensitization of Vascular Smooth Muscle. 
  • A comparison of the vasodilating effects of halothane and isoflurane on the isolated rabbit basilar artery with and without intact endothelium. 
  • A critical role for chloride channel-3 (CIC-3) in smooth muscle cell activation and neointima formation. 
  • A cystine-cysteine shuttle mediated by xCT facilitates cellular responses to S-nitrosoalbumin. 
  • A differential role for endocytosis in receptor-mediated activation of Nox1. 
  • A gene therapy strategy using a transcription factor decoy of the E2F binding site inhibits smooth muscle proliferation in vivo. 
  • A mathematical model of the myogenic response to systolic pressure in the afferent arteriole. 
  • A neutrophil derived factor(s) stimulates [3H]thymidine incorporation by vascular smooth muscle cells in vitro. 
  • A novel inhaled organic nitrate that affects pulmonary vascular tone in a piglet model of hypoxia-induced pulmonary hypertension. 
  • A novel role for the cyclin-dependent kinase inhibitor p27(Kip1) in angiotensin II-stimulated vascular smooth muscle cell hypertrophy. 
  • A requirement for rac1 in the PDGF-stimulated migration of fibroblasts and vascular smooth cells. 
  • A role for endogenous endothelin-1 in neointimal formation after rat carotid artery balloon angioplasty. Protective effects of the novel nonpeptide endothelin receptor antagonist SB 209670. 
  • A system for the direct co-culture of endothelium on smooth muscle cells. 
  • A20, a modulator of smooth muscle cell proliferation and apoptosis, prevents and induces regression of neointimal hyperplasia. 
  • AIF-1 in the activated smooth muscle cell : spectator or participant? 
  • AT2 receptor and vascular smooth muscle cell differentiation in vascular development. 
  • Absence of metabolite formation during nitroglycerin-induced relaxation of isolated blood vessels. 
  • Activated alpha 2-macroglobulin promotes mitogenesis in rat vascular smooth muscle cells by a mechanism that is independent of growth-factor-carrier activity. 
  • Activated monocytes induce smooth muscle cell death: role of macrophage colony-stimulating factor and cell contact. 
  • Activation in the region of parabrachial nucleus elicits neurogenically mediated coronary vasoconstriction. 
  • Activation of NADPH oxidase 1 increases intracellular calcium and migration of smooth muscle cells. 
  • Activation of pp60c-src is necessary for human vascular smooth muscle cell migration. 
  • Activation of vascular smooth muscle cells by TNF and PDGF: overlapping and complementary signal transduction mechanisms. 
  • Adaptive responses to peroxynitrite: increased glutathione levels and cystine uptake in vascular cells. 
  • Adenoviral gene transfer of nitric oxide synthase: high level expression in human vascular cells. 
  • Aldosterone increases oxidant stress to impair guanylyl cyclase activity by cysteinyl thiol oxidation in vascular smooth muscle cells. 
  • Aldosterone-induced activation of signaling pathways requires activity of angiotensin type 1a receptors. 
  • Alpha 1-adrenergic receptor mRNA level is regulated by norepinephrine in rabbit aortic smooth muscle cells. 
  • Alpha 1-adrenoceptor activity in arterial smooth muscle following congestive heart failure. 
  • Ambient but not incremental oxidant generation effects intercellular adhesion molecule 1 induction by tumour necrosis factor alpha in endothelium. 
  • Amiprilose hydrochloride inhibits porcine aortic smooth muscle cell proliferation in vitro. 
  • An oxidized extracellular oxidation-reduction state increases Nox1 expression and proliferation in vascular smooth muscle cells via epidermal growth factor receptor activation. 
  • Angiogenesis-like activity of endothelial cells co-cultured with VEGF-producing smooth muscle cells. 
  • Angiotensin AT1B receptor mediates calcium signaling in vascular smooth muscle cells of AT1A receptor-deficient mice. 
  • Angiotensin II can regulate gene expression by the AP-1 binding sequence via a protein kinase C-dependent pathway. 
  • Angiotensin II type 1 receptor-associated protein is an endogenous inhibitor of angiotensin II type 1 receptor action in cardiac hypertrophy: role in check and balance. 
  • Angiotensin II type 1A receptors in vascular smooth muscle cells do not influence aortic remodeling in hypertension. 
  • Angiotensin II type 2 receptor mediates vascular smooth muscle cell apoptosis and antagonizes angiotensin II type 1 receptor action: an in vitro gene transfer study. 
  • Angiotensin II-induced hypertrophy of rat vascular smooth muscle is associated with increased 18 S rRNA synthesis and phosphorylation of the rRNA transcription factor, upstream binding factor. 
  • Angiotensin converting enzyme inhibition and vascular hypertrophy in hypertension. 
  • Angiotensin type 2 receptor is expressed in murine atherosclerotic lesions and modulates lesion evolution. 
  • Anisodamine at higher concentrations in inhibiting alpha-adrenergic responses in isolated canine blood vessels. 
  • Antioxidant and cytotoxic tocopheryl quinones in normal and cancer cells. 
  • Antisense oligodeoxynucleotide inhibition of vascular angiotensin-converting enzyme expression attenuates neointimal formation: evidence for tissue angiotensin-converting enzyme function. 
  • Antisense oligonucleotides directed at cell cycle regulatory genes as strategy for restenosis therapy. 
  • Antisense technology to block autocrine growth factors. 
  • Aortic aneurysms: It's all about the stress. 
  • Apocynin alters redox signaling in conductance and resistance vessels of spontaneously hypertensive rats. 
  • Application of magnetic resonance microscopy to tissue engineering: a polylactide model. 
  • Arachidonic acid metabolism in cultured aortic endothelial cells. Effect of cAMP and 3-isobutyl-1-methylxanthine. 
  • Arachidonic acid stimulates protein tyrosine phosphorylation in vascular cells. 
  • Arterial gene transfer of the TGF-beta signalling protein Smad3 induces adaptive remodelling following angioplasty: a role for CTGF. 
  • Atrial natriuretic polypeptide inhibits hypertrophy of vascular smooth muscle cells. 
  • Augmented tissue oxygen supply during striated muscle contraction in the hamster. Relative contributions of capillary recruitment, functional dilation, and reduced tissue PO2. 
  • Autocrine and paracrine effects of atrial natriuretic peptide gene transfer on vascular smooth muscle and endothelial cellular growth. 
  • Autocrine-paracrine mechanisms of vascular myocytes in systemic hypertension. 
  • Autoregulation and conduction of vasomotor responses in a mathematical model of the rat afferent arteriole. 
  • Autoregulation of polypyrimidine tract binding protein by alternative splicing leading to nonsense-mediated decay. 
  • Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7. 
  • Beta-arrestin-mediated signaling regulates protein synthesis. 
  • Bioengineered human acellular vessels for dialysis access in patients with end-stage renal disease: two phase 2 single-arm trials. 
  • Biology of intracranial aneurysms: role of inflammation. 
  • Biomechanical effects of flow and coculture on human aortic and cord blood-derived endothelial cells. 
  • Blood pressure homeostasis is maintained by a P311-TGF-β axis. 
  • Blood pressure-associated polymorphism controls ARHGAP42 expression via serum response factor DNA binding. 
  • Blood vessels engineered from human cells. 
  • Blood-induced arterial segmental spasm. 
  • Bone marrow-derived progenitor cells contribute to experimental choroidal neovascularization. 
  • CCR2 deficiency, dysregulation of Notch signaling, and spontaneous pulmonary arterial hypertension. 
  • CYP2J subfamily P450s in the lung: expression, localization, and potential functional significance. 
  • Calcium channel blockers reduce blood pressure in part by inhibiting vascular smooth muscle carbonic anhydrase I. 
  • Calcium dynamics underlying the myogenic response of the renal afferent arteriole. 
  • Cardiac chimerism as a mechanism for self-repair: does it happen and if so to what degree? 
  • Cardiac neural crest is necessary for normal addition of the myocardium to the arterial pole from the secondary heart field. 
  • Cell adhesion peptides alter smooth muscle cell adhesion, proliferation, migration, and matrix protein synthesis on modified surfaces and in polymer scaffolds. 
  • Cell biology of vascular hypertrophy in systemic hypertension. 
  • Cell cycle progression: new therapeutic target for vascular proliferative disease. 
  • Cell cycle protein expression in vascular smooth muscle cells in vitro and in vivo is regulated through phosphatidylinositol 3-kinase and mammalian target of rapamycin. 
  • Cell cycle-dependent regulation of smooth muscle cell activation. 
  • Cellular and molecular mechanisms of coronary artery restenosis. 
  • Cerebral blood flow and oxygen delivery during hypoxemia and hemodilution: role of arterial oxygen content. 
  • Cerebral cortical arteriolar angiopathy, vascular beta-amyloid, smooth muscle actin, Braak stage, and APOE genotype. 
  • Cerebrovascular smooth muscle actin is increased in nondemented subjects with frequent senile plaques at autopsy: implications for the pathogenesis of Alzheimer disease. 
  • Chronic ACE inhibition reduces intimal hyperplasia in experimental vein grafts. 
  • Cigarette smoke and inflammation: role in cerebral aneurysm formation and rupture. 
  • Cigarette smoke modulates vascular smooth muscle phenotype: implications for carotid and cerebrovascular disease. 
  • Clinical trials of restenosis after coronary angioplasty. 
  • Cloned endothelium derived from autoimmune vascular disease retain structural and functional characteristics of normal endothelial cells. 
  • Comparative effects of basic fibroblast growth factor and vascular endothelial growth factor on coronary collateral development and the arterial response to injury. 
  • Comparison of aortic intima and inner media in young adult versus aging rats. Stereology in a polarized system. 
  • Comparison of plasminogen binding and activation on extracellular matrices produced by vascular smooth muscle and endothelial cells. 
  • Comparison of relaxation responses to multiple vasodilators in TxA(2)-analog and endothelin-1-precontracted pulmonary arteries. 
  • Competing G protein-coupled receptor kinases balance G protein and β-arrestin signaling. 
  • Correlation of clinical history with quantitative histology of lower extremity atheroma biopsies obtained with the Simpson atherectomy catheter. 
  • Covalently immobilized gradients of bFGF on hydrogel scaffolds for directed cell migration. 
  • Cytokine activation of nuclear factor kappa B in vascular smooth muscle cells requires signaling endosomes containing Nox1 and ClC-3. 
  • Cytotoxicity of oxidized LDL to porcine aortic smooth muscle cells is associated with the oxysterols 7-ketocholesterol and 7-hydroxycholesterol. 
  • DNA transfer into vascular smooth muscle using fusigenic Sendai virus (HVJ)-liposomes. 
  • Decellularized native and engineered arterial scaffolds for transplantation. 
  • Decreases in corporeal vascular endothelial growth factor expression precede vasoreactivity changes in cholesterol fed rabbits. 
  • Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle. 
  • Demonstration of coronary artery myogenic vasoconstriction in the awake dog. 
  • Depletion of arterial L-arginine causes reversible tolerance to endothelium-dependent relaxation. 
  • Depletion of intracellular calcium stores activates smooth muscle cell calcium-independent phospholipase A2. A novel mechanism underlying arachidonic acid mobilization. 
  • Differences in direct pharmacologic effects and antioxidative properties of mature breast milk and infant formulas. 
  • Differential effect of nitric oxide on thrombospondin-1-, PDGF- and fibronectin-induced migration of vascular smooth muscle cells. 
  • Differential effects of platelet-derived growth factor isotypes on human smooth muscle cell proliferation and migration are mediated by distinct signaling pathways. 
  • Direct-contact co-culture between smooth muscle and endothelial cells inhibits TNF-alpha-mediated endothelial cell activation. 
  • Distinct roles of E2F proteins in vascular smooth muscle cell proliferation and intimal hyperplasia. 
  • Distribution of shear stress over smooth muscle cells in deformable arterial wall. 
  • Drebrin regulates angiotensin II-induced aortic remodelling. 
  • Dual actions of S-nitrosylated derivative of vasoactive intestinal peptide as a vasoactive intestinal peptide-like mediator and a nitric oxide carrier. 
  • Effect of antineoplastic agents on smooth muscle cell proliferation in vitro: implications for prevention of restenosis after transluminal angioplasty. 
  • Effect of ionizing radiation on thymidine uptake, differentiation, and VEGFR2 receptor expression in endothelial cells: the role of VEGF(165). 
  • Effect of the shape and configuration of smooth muscle cells on the diffusion of ATP through the arterial wall. 
  • Effects of ammonium ion derived from bovine endothelial cells upon low density lipoprotein degradation in cultured vascular smooth muscle cells. 
  • Effects of cardiopulmonary bypass and circulatory arrest on endothelium-dependent vasodilation in the lung. 
  • Effects of distention and short-term grafting on vasoreactivity in rabbit external jugular veins. 
  • Effects of treatment with cyclosporine, FK 506, rapamycin, mycophenolic acid, or deoxyspergualin on vascular muscle proliferation in vitro and in vivo. 
  • Efficient adenoviral gene transfer to early venous bypass grafts: comparison with native vessels. 
  • Elemental composition of Na pump inhibited rabbit aorta VSM cells by electron probe X-ray microanalysis. 
  • Endoglin Mediates Vascular Maturation by Promoting Vascular Smooth Muscle Cell Migration and Spreading. 
  • Endothelial cell-conditioned medium downregulates smooth muscle contractile protein expression. 
  • Endothelial dysfunction in cerebral microcirculation during hypothermic cardiopulmonary bypass in newborn lambs. 
  • Endothelial healing in vein grafts: proliferative burst unimpaired by genetic therapy of neointimal disease. 
  • Endothelial heparan sulfate is necessary but not sufficient for control of vascular smooth muscle cell growth. 
  • Endothelin-1 induces an increase in total protein synthesis and expression of the smooth muscle alpha-actin gene in vascular smooth muscle cells. 
  • Endothelin-1 selectively contracts portal vein through both ETA and ETB receptors in isolated rabbit liver. 
  • Endothelium modulation of the effects of nitroglycerin on blood vessels from dogs with pacing-induced heart failure. 
  • Enhanced H(2)O(2)-induced cytotoxicity in "epithelioid" smooth muscle cells: implications for neointimal regression. 
  • Enhanced vasorelaxation by overexpression of beta 2-adrenergic receptors in large arteries. 
  • Ethacrynic acid: acute hemodynamic effects and influence on the in vivo and in vitro response to nitroglycerin in the dog. 
  • Evidence for direct local effect of angiotensin in vascular hypertrophy. In vivo gene transfer of angiotensin converting enzyme. 
  • Evidence for myogenic vasomotor activity in the coronary circulation. 
  • Experimental aortocoronary saphenous vein graft function after mechanical cardiac massage with the Anstadt Cup. 
  • Expression of renin-angiotensin system and extracellular matrix genes in cardiovascular cells and its regulation through AT1 receptor. 
  • Expression of the AT2 receptor developmentally programs extracellular signal-regulated kinase activity and influences fetal vascular growth. 
  • Extrarenal contributions to indapamide's antihypertensive mechanism of action. 
  • Feasibility of vitrification as a storage method for tissue-engineered blood vessels. 
  • Fetal-derived adrenomedullin mediates the innate immune milieu of the placenta. 
  • Fetuin-A uptake in bovine vascular smooth muscle cells is calcium dependent and mediated by annexins. 
  • Fibroblast growth factor 23 is not associated with and does not induce arterial calcification. 
  • Focal toxicity of oxysterols in vascular smooth muscle cell culture. A model of the atherosclerotic core region. 
  • Functional characterization of two S-nitroso-L-cysteine transporters, which mediate movement of NO equivalents into vascular cells. 
  • G protein-coupled receptor kinase 5 in cultured vascular smooth muscle cells and rat aorta. Regulation by angiotensin II and hypertension. 
  • G protein-coupled receptor kinase-5 attenuates atherosclerosis by regulating receptor tyrosine kinases and 7-transmembrane receptors. 
  • Gender and estrogen supplementation increases severity of experimental choroidal neovascularization. 
  • Gene expression of the renin-angiotensin system in human tissues. Quantitative analysis by the polymerase chain reaction. 
  • Gene expression programs of human smooth muscle cells: tissue-specific differentiation and prognostic significance in breast cancers. 
  • Genetic and functional association of FAM5C with myocardial infarction. 
  • Genetic engineering of vein grafts resistant to atherosclerosis. 
  • Genetic targeting for cardiovascular therapeutics: are we near the summit or just beginning the climb? 
  • Glucose activates mitogen-activated protein kinase (extracellular signal-regulated kinase) through proline-rich tyrosine kinase-2 and the Glut1 glucose transporter. 
  • Glutathione peroxidase-deficient smooth muscle cells cause paracrine activation of normal smooth muscle cells via cyclophilin A. 
  • Gp91phox contributes to NADPH oxidase activity in aortic fibroblasts but not smooth muscle cells. 
  • H(2)O(2)-induced O(2) production by a non-phagocytic NAD(P)H oxidase causes oxidant injury. 
  • H19, a developmentally regulated gene, is reexpressed in rat vascular smooth muscle cells after injury. 
  • HIV envelope gp120 activates human arterial smooth muscle cells. 
  • Hemodynamic parameters and early intimal thickening in branching blood vessels. 
  • High cholesterol feeding in C57/Blc6 mice alters expression within the VEGF receptor-ligand family in corporal tissue. 
  • Human saphenous vein grafts explanted from the arterial circulation demonstrate altered smooth-muscle and endothelial responses. 
  • Human smooth muscle alpha-actin gene is a transcriptional target of the p53 tumor suppressor protein. 
  • Hypotensive and vasorelaxant effect of Diapocynin in normotensive rats. 
  • Hypoxia inhibits nitric oxide synthesis in isolated rabbit lung. 
  • Identification of the enzymatic mechanism of nitroglycerin bioactivation. 
  • Identification of two calcium channel receptor sites for [3H]nitrendipine in mammalian cardiac and smooth muscle membrane. 
  • Impairment of intracerebral arteriole dilation responses after subarachnoid hemorrhage. Laboratory investigation. 
  • Inactivation of the tumour suppressor, PTEN, in smooth muscle promotes a pro-inflammatory phenotype and enhances neointima formation. 
  • Increased epidermal growth factor-like ligands are associated with elevated vascular nicotinamide adenine dinucleotide phosphate oxidase in a primate model of atherosclerosis. 
  • Increased expression of Nox1 in neointimal smooth muscle cells promotes activation of matrix metalloproteinase-9. 
  • Increased vascular contraction and sensitivity to norepinephrine after endothelial denudation is inhibited by prazosin. 
  • Increased vascular smooth muscle contractility in TRPC6-/- mice. 
  • Independent beta-arrestin2 and Gq/protein kinase Czeta pathways for ERK stimulated by angiotensin type 1A receptors in vascular smooth muscle cells converge on transactivation of the epidermal growth factor receptor. 
  • Induction of angiotensin converting enzyme in the neointima after vascular injury. Possible role in restenosis. 
  • Induction of platelet-derived growth factor A-chain and c-myc gene expressions by angiotensin II in cultured rat vascular smooth muscle cells. 
  • Inhibition by nicardipine of endothelin-mediated inositol phosphate formation and Ca2+ mobilization in smooth muscle cell. 
  • Inhibition of apoptotic signaling and neointimal hyperplasia by tempol and nitric oxide synthase following vascular injury. 
  • Inhibition of vascular smooth muscle cell proliferation, migration, and survival by the tumor suppressor protein PTEN. 
  • Inhibitory role of the coronary arterial endothelium to alpha-adrenergic stimulation in experimental heart failure. 
  • Interaction of atrial natriuretic polypeptide and angiotensin II on protooncogene expression and vascular cell growth. 
  • Interactions of magnesium and verapamil on tone and contractility of vascular smooth muscle. 
  • Interferon regulatory factors regulate interleukin-1beta-converting enzyme expression and apoptosis in vascular smooth muscle cells. 
  • Intimal hyperplasia after vascular injury is inhibited by antisense cdk 2 kinase oligonucleotides. 
  • Intracellular calcium transients are necessary for platelet-derived growth factor but not extracellular matrix protein-induced vascular smooth muscle cell migration. 
  • Investigation of the role of prostaglandins in nitroglycerin-induced relaxation of isolated rabbit blood vessels. 
  • Investigations into the role of sulfhydryl groups in the mechanism of action of the nitrates. 
  • Irradiation for intimal hyperplasia: implications for peripheral arterial bypass. 
  • Kalirin promotes neointimal hyperplasia by activating Rac in smooth muscle cells. 
  • Kruppel-like factor 15 is critical for vascular inflammation. 
  • Laminar shear stress stimulates vascular smooth muscle cell apoptosis via the Akt pathway. 
  • Local expression and pathophysiological role of renin-angiotensin in the blood vessels and heart. 
  • Locational stereology performed within sampling fields in rat aortic wall, a polarized tissue. 
  • Long-term stabilization of vein graft wall architecture and prolonged resistance to experimental atherosclerosis after E2F decoy oligonucleotide gene therapy. 
  • Low-level endotoxin induces potent inflammatory activation of human blood vessels: inhibition by statins. 
  • MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound β(2)-adrenergic receptors. 
  • Mas oncogene receptor coupling and peptide specificity in Balb 3T3 and vascular smooth muscle cells. 
  • Mast cell infiltration: a possible mechanism for vein graft vasospasm. 
  • Measurement of arterial pressure-dimension relationships in conscious animals. 
  • Measurement of prostaglandin production by isolated tissues and cells in culture. 
  • Mechanism of bradykinin-stimulated prostacyclin synthesis in porcine aortic endothelial cells. 
  • Medical approaches to prevention of restenosis after coronary angioplasty. 
  • Mesothelium contributes to vascular smooth muscle and mesenchyme during lung development. 
  • Metabolic cooperation between vascular endothelial cells and smooth muscle cells in co-culture: changes in low density lipoprotein metabolism. 
  • Methylation of the estrogen receptor gene is associated with aging and atherosclerosis in the cardiovascular system. 
  • Methylation of the estrogen receptor-alpha gene promoter is selectively increased in proliferating human aortic smooth muscle cells. 
  • MicroRNA-145 restores contractile vascular smooth muscle phenotype and coronary collateral growth in the metabolic syndrome. 
  • Microvascular determinants of blood flow. 
  • Microvascular notch signaling is upregulated in response to vascular endothelial growth factor and chronic myocardial ischemia. 
  • Mitogenic effect of neuropeptide Y in rat vascular smooth muscle cells. 
  • Modulation of phosphatidylinositol 3-kinase signaling reduces intimal hyperplasia in aortocoronary saphenous vein grafts. 
  • Molecular cloning and characterization of the intermediate-conductance Ca(2+)-activated K(+) channel in vascular smooth muscle: relationship between K(Ca) channel diversity and smooth muscle cell function. 
  • Molecular mechanism of fibronectin gene activation by cyclic stretch in vascular smooth muscle cells. 
  • Molecular mechanisms of vascular renin-angiotensin system in myointimal hyperplasia. 
  • Molecular therapies for vascular diseases. 
  • Multiple autocrine growth factors modulate vascular smooth muscle cell growth response to angiotensin II. 
  • Multiple polyamine regulatory pathways control compensatory cardiovascular hypertrophy in coarctation hypertension. 
  • Myogenic constriction of human coronary arterioles. 
  • N-acetylcysteine does not modify nitroglycerin-induced tolerance in canine vascular rings. 
  • NADPH oxidase 4: walking the walk with Poldip2. 
  • Nanopattern-induced changes in morphology and motility of smooth muscle cells. 
  • Nicotine increases size and severity of experimental choroidal neovascularization. 
  • Nitric oxide synthase inhibition irreversibly decreases perfusion in the R3230Ac rat mammary adenocarcinoma. 
  • Nitric oxide-generating polymers reduce platelet adhesion and smooth muscle cell proliferation. 
  • Nitric oxide-producing polyurethanes. 
  • Norepinephrine-induced down regulation of alpha 1 adrenergic receptors in cultured rabbit aorta smooth muscle cells. 
  • Novel and effective gene transfer technique for study of vascular renin angiotensin system. 
  • Novel in vitro gene transfer method for study of local modulators in vascular smooth muscle cells. 
  • Novel small leucine-rich repeat protein podocan is a negative regulator of migration and proliferation of smooth muscle cells, modulates neointima formation, and is expressed in human atheroma. 
  • Novel vascular effects of isoprenaline following pacing-induced heart failure in the dog. 
  • Nox1 transactivation of epidermal growth factor receptor promotes N-cadherin shedding and smooth muscle cell migration. 
  • Overcoming Chronic Rejection-Can it B? 
  • Overexpression of G protein-coupled receptor kinase-2 in smooth muscle cells attenuates mitogenic signaling via G protein-coupled and platelet-derived growth factor receptors. 
  • Overexpression of human catalase inhibits proliferation and promotes apoptosis in vascular smooth muscle cells. 
  • Pathogenesis of varicose veins. 
  • Pathophysiology of vascular smooth muscle in renin promoter-T-antigen transgenic mice. 
  • Patterns of cardiovascular responses to stress as a function of race and parental hypertension in men. 
  • Perfluorooctyl bromide (perflubron) attenuates oxidative injury to biological and nonbiological systems. 
  • Pharmacological strategies to prevent restenosis: lessons learned from blockade of the renin-angiotensin system. 
  • Phorbol ester effects on alpha 1-adrenoceptor binding and phosphatidylinositol metabolism in cultured vascular smooth muscle cells. 
  • Phosphorylation of Nox1 regulates association with NoxA1 activation domain. 
  • Phosphorylation of caldesmon by mitogen-activated protein kinase with no effect on Ca2+ sensitivity in rabbit smooth muscle. 
  • Phosphorylation of the rRNA transcription factor upstream binding factor promotes its association with TATA binding protein. 
  • Photoaffinity labeling of mammalian alpha 1-adrenergic receptors. Identification of the ligand binding subunit with a high affinity radioiodinated probe. 
  • Physiological genomics of human arteries: quantitative relationship between gene expression and arterial stiffness. 
  • Plasminogen activator inhibitor-1 regulates myoendothelial junction formation. 
  • Platelet-activating factor-induced homologous and heterologous desensitization in cultured vascular smooth muscle cells. 
  • Possible role for vascular cell proliferation in cerebral vasospasm after subarachnoid hemorrhage. 
  • Predicted effects of nitric oxide and superoxide on the vasoactivity of the afferent arteriole. 
  • Pressure-mediated oligonucleotide transfection of rat and human cardiovascular tissues. 
  • Protein kinase C isoforms in human aortic smooth muscle cells. 
  • Quantitative enumeration of vascular smooth muscle cells and endothelial cells derived from bone marrow precursors in experimental choroidal neovascularization. 
  • Rapamycin inhibits fibronectin-induced migration of the human arterial smooth muscle line (E47) through the mammalian target of rapamycin. 
  • Rapid identification of cell-specific, internalizing RNA aptamers with bioinformatics analyses of a cell-based aptamer selection. 
  • Readily available tissue-engineered vascular grafts. 
  • Reconstruction of rat femoral veins with microvascular prostheses. 
  • Recovery of impaired endothelium-dependent relaxation after fluid-percussion brain injury in cats. 
  • Redox Activation of Nox1 (NADPH Oxidase 1) Involves an Intermolecular Disulfide Bond Between Protein Disulfide Isomerase and p47phox in Vascular Smooth Muscle Cells. 
  • Redox regulation of vascular smooth muscle cell differentiation. 
  • Redox signaling of the arteriolar myogenic response. 
  • Reduction of experimental vein graft intimal hyperplasia by ketanserin. 
  • Reduction of intimal hyperplasia and enhanced reactivity of experimental vein bypass grafts with verapamil treatment. 
  • Regions of the 110-kDa regulatory subunit M110 required for regulation of myosin-light-chain-phosphatase activity in smooth muscle. 
  • Regulation of 12-lipoxygenase by cytokines in vascular smooth muscle cells. 
  • Regulation of endothelin-induced Ca2+ mobilization in smooth muscle cells by protein kinase C. 
  • Regulation of endothelin-mediated calcium mobilization in vascular smooth muscle cells by isoproterenol. 
  • Regulation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-5 in vascular smooth muscle cells involves the phosphatase Shp2. 
  • Relevance and safety of telomerase for human tissue engineering. 
  • Remodeling and reparation of the cardiovascular system. 
  • Renin synthesis by canine aortic smooth muscle cells in culture. 
  • Rho A/Rho kinase: human umbilical artery mRNA expression in normal and pre eclamptic pregnancies and functional role in isoprostane-induced vasoconstriction. 
  • RhoA inactivation by S-nitrosylation regulates vascular smooth muscle contractive signaling. 
  • Role of AP-1 complex in angiotensin II-mediated transforming growth factor-beta expression and growth of smooth muscle cells: using decoy approach against AP-1 binding site. 
  • Role of Mammalian Target of Rapamycin in Atherosclerosis. 
  • Role of prostacyclin in the cardiovascular response to thromboxane A2. 
  • Role of protein kinase C (PKC) in mediating Ca2+ entry in vascular smooth muscle cells. 
  • Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility. 
  • Role of vascular mitogens in subarachnoid hemorrhage-associated cerebral vasculopathy. 
  • Saphenous vein endothelium-dependent relaxation in patients with peripheral vascular disease. 
  • Secondary heart field contributes myocardium and smooth muscle to the arterial pole of the developing heart. 
  • Selective supersensitivity to norepinephrine in intimal thickened rabbit aorta. 
  • Single intraluminal delivery of antisense cdc2 kinase and proliferating-cell nuclear antigen oligonucleotides results in chronic inhibition of neointimal hyperplasia. 
  • Smooth Muscle Cell-targeted RNA Aptamer Inhibits Neointimal Formation. 
  • Smooth muscle cell growth in photopolymerized hydrogels with cell adhesive and proteolytically degradable domains: synthetic ECM analogs for tissue engineering. 
  • Smooth muscle cell migration and proliferation are mediated by distinct phases of activation of the intracellular messenger mitogen-activated protein kinase. 
  • Smooth muscle cell rigidity and extracellular matrix organization influence endothelial cell spreading and adhesion formation in coculture. 
  • Smooth muscle cell signal transduction: implications of vascular biology for vascular surgeons. 
  • Smooth muscle growth and cholesterol accumulation in atherogenesis. 
  • Sox6 as a new modulator of renin expression in the kidney. 
  • Statins and nitric oxide donors affect thrombospondin 1-induced chemotaxis. 
  • Stem cell factor and c-kit are expressed by and may affect vascular SMCs through an autocrine pathway. 
  • Superoxide production in vascular smooth muscle contributes to oxidative stress and impaired relaxation in atherosclerosis. 
  • TGF-beta through Smad3 signaling stimulates vascular smooth muscle cell proliferation and neointimal formation. 
  • TNF-α induces phenotypic modulation in cerebral vascular smooth muscle cells: implications for cerebral aneurysm pathology. 
  • TRPV4 Is Required for Hypoxic Pulmonary Vasoconstriction. 
  • TRPV4-dependent dilation of peripheral resistance arteries influences arterial pressure. 
  • Targeting Gbeta gamma signaling in arterial vascular smooth muscle proliferation: a novel strategy to limit restenosis. 
  • Tethered-TGF-beta increases extracellular matrix production of vascular smooth muscle cells. 
  • Thapsigargin stimulates Ca2+ entry in vascular smooth muscle cells: nicardipine-sensitive and -insensitive pathways. 
  • The Actin-Binding Protein Drebrin Inhibits Neointimal Hyperplasia. 
  • The CXC chemokine cCAF stimulates precocious deposition of ECM molecules by wound fibroblasts, accelerating development of granulation tissue. 
  • The angiotensin II type 2 (AT2) receptor antagonizes the growth effects of the AT1 receptor: gain-of-function study using gene transfer. 
  • The arterial wall and the atherosclerotic lesion. 
  • The coronary artery response to implantation of a balloon-expandable flexible stent in the aspirin- and non-aspirin-treated swine model. 
  • The effect of exposure time on microsurgical anastomoses of experimentally crushed arteries. 
  • The effects of nicotine on vascular smooth muscle cell chemotaxis induced by thrombospondin-1 and fibronectin. 
  • The role of aspirin and dipyridamole on vascular DNA synthesis and intimal hyperplasia following deendothelialization. 
  • The role of integrins in saphenous vein vascular smooth muscle cell migration. 
  • The role of mechanical and humoral factors in growth regulation of vascular smooth muscle and cardiac myocytes. 
  • The role of β-arrestin2-dependent signaling in thoracic aortic aneurysm formation in a murine model of Marfan syndrome. 
  • The use of micropatterning to control smooth muscle myosin heavy chain expression and limit the response to transforming growth factor β1 in vascular smooth muscle cells. 
  • The vascular NADPH oxidase subunit p47phox is involved in redox-mediated gene expression. 
  • Theoretical assessment of renal autoregulatory mechanisms. 
  • Thromboxane receptors in smooth muscle promote hypertension, vascular remodeling, and sudden death. 
  • Tissue angiotensin system in cardiovascular medicine. A paradigm shift? 
  • Toxicity of oxidized low density lipoproteins for vascular smooth muscle cells and partial protection by antioxidants. 
  • Transfer Function Analysis of Dynamic Blood Flow Control in the Rat Kidney. 
  • Transforming growth factor-beta1 inhibition of vascular smooth muscle cell activation is mediated via Smad3. 
  • Transplantation of embryonic stem cells into the infarcted mouse heart: formation of multiple cell types. 
  • Treatment with rapamycin and mycophenolic acid reduces arterial intimal thickening produced by mechanical injury and allows endothelial replacement. 
  • Tumor invasion of muscular vessels predicts poor prognosis in patients with pancreatic ductal adenocarcinoma who have received neoadjuvant therapy and pancreaticoduodenectomy. 
  • UDP acts as a growth factor for vascular smooth muscle cells by activation of P2Y(6) receptors. 
  • USP20 (Ubiquitin-Specific Protease 20) Inhibits TNF (Tumor Necrosis Factor)-Triggered Smooth Muscle Cell Inflammation and Attenuates Atherosclerosis. 
  • Upregulation of osmo-mechanosensitive TRPV4 channel facilitates chronic hypoxia-induced myogenic tone and pulmonary hypertension. 
  • Use of balloon-expandable stents to treat experimental peripheral pulmonary artery and superior vena caval stenosis: preliminary experience. 
  • Utility of telomerase-pot1 fusion protein in vascular tissue engineering. 
  • Vascular Type 1A Angiotensin II Receptors Control BP by Regulating Renal Blood Flow and Urinary Sodium Excretion. 
  • Vascular biology: the past 50 years. 
  • Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2. 
  • Vascular remodeling--the emerging paradigm of programmed cell death (apoptosis): the Francis B. Parker lectureship. 
  • Vascular remodeling: mechanisms and implications. 
  • Vascular renin-angiotensin system and vascular protection. 
  • Vascular renin-angiotensin: a possible autocrine or paracrine system in control of vascular function. 
  • Vascular smooth muscle actin is reduced in Alzheimer disease brain: a quantitative analysis. 
  • Vascular smooth muscle cell hypertrophy vs. hyperplasia. Autocrine transforming growth factor-beta 1 expression determines growth response to angiotensin II. 
  • Vascular smooth muscle cell migration induced by domains of thrombospondin-1 is differentially regulated. 
  • Vascular smooth muscle responsiveness to noradrenaline and phenylephrine following experimental heart failure in dogs. 
  • Vascular tone pathway polymorphisms in relation to primary open-angle glaucoma. 
  • Vascular wall renin-angiotensin pathway in control of the circulation. A hypothesis. 
  • Vascular-targeted overexpression of G protein-coupled receptor kinase-2 in transgenic mice attenuates beta-adrenergic receptor signaling and increases resting blood pressure. 
  • Vasopressin: a new target for the treatment of heart failure. 
  • YC-1-mediated vascular protection through inhibition of smooth muscle cell proliferation and platelet function. 
  • [Experimental approaches for gene therapy modification of vascular remodeling]. 
  • eNOS-overexpressing endothelial cells inhibit platelet aggregation and smooth muscle cell proliferation in vitro. 
  • {beta}-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation. 
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  Keywords of People

  • Gunn, Michael Dee, Professor of Medicine, Immunology
  • Hogan, Brigid L. M., George Barth Geller Distinguished Professor of Immunology, Cell Biology
  • Liu, Yutao, Adjunct Assistant Professor in the Department of Medicine, Medicine, Medical Genetics
  • Middleton, John Paul, Associate Professor of Medicine, Medicine, Nephrology
  • Milano, Carmelo Alessio, Professor of Surgery, Surgery, Cardiovascular and Thoracic Surgery
  • O'Connor, Christopher Michael, Richard Sean Stack, M.D. Distinguished Professor, Medicine, Clinical Pharmacology
  • Sparks, Matthew A., Assistant Professor of Medicine, Medicine, Nephrology
  • Warner, David Samuel, Distinguished Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology