Mutagenicity Tests

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  Subject Areas on Research

  • A preliminary investigation of the parallelogram concept in genetic monitoring and risk estimation. 
  • Bayesian latent variable models for median regression on multiple outcomes. 
  • Chromium(III) picolinate produces chromosome damage in Chinese hamster ovary cells. 
  • Chromosomes with high gene density are preferentially repaired in human cells. 
  • Clastogenicity of lead chromate particles in hamster and human cells. 
  • Comments on 'Cytogenetic effects in children treated with methylphenidate' by El-Zein et al. 
  • Comparison of human and rat hepatocyte metabolism and mutagenic activation of 2-acetylaminofluorene. 
  • DNA strand breakage, cytotoxicity and mutagenicity of hydrogen peroxide treatment at 4 degrees C and 37 degrees C in L5178Y sublines. 
  • Demonstrating mutagenicity using the Ames test. 
  • Endonuclease-independent DNA mismatch repair processes on the lagging strand. 
  • Genotoxicity in Atlantic killifish (Fundulus heteroclitus) from a PAH-contaminated Superfund site on the Elizabeth River, Virginia. 
  • Improved EBV shuttle vectors. 
  • In vitro and in vivo genotoxicity evaluation of hormonal drugs. I. Hydrocortisone. 
  • In vitro and in vivo genotoxicity evaluation of hormonal drugs. II. Dexamethasone. 
  • International Commission for Protection Against Environmental Mutagens and Carcinogens. Mutagenicity and carcinogenicity of topoisomerase-interactive agents. 
  • Interspecies cytogenetic comparisons: studies with X-radiation and bleomycin sulfate. 
  • Modeling the Ames test. 
  • Morphologic and functional studies of mouse hepatocytes in primary culture. 
  • Morphological and neoplastic transformation of C3H/10T1/2 Cl 8 mouse embryo cells by insoluble carcinogenic nickel compounds. 
  • Mutation, DNA strand cleavage and nitric oxide formation caused by N-nitrosoproline with sunlight: a possible mechanism of UVA carcinogenicity. 
  • New investigations into the genotoxicity of cobalt compounds and their impact on overall assessment of genotoxic risk. 
  • Nonclinical Safety and Toxicokinetics of MnTnBuOE-2-PyP5+ (BMX-001). 
  • Occupational exposure of nursing personnel to antineoplastic agents. 
  • Ochratoxin A-induced cytotoxicity, genotoxicity and reactive oxygen species in kidney cells: An integrative approach of complementary endpoints. 
  • Permeability of four disposable protective-clothing materials to seven antineoplastic drugs. 
  • Permeability of latex and polyvinyl chloride gloves to carmustine. 
  • Prospective analysis of DNA damage and repair markers of lung cancer risk from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. 
  • QPCR: a tool for analysis of mitochondrial and nuclear DNA damage in ecotoxicology. 
  • Re-evaluation of urine mutagenicity of pharmacy personnel exposed to antineoplastic agents. 
  • Reliability of mutagen sensitivity assay: an inter-laboratory comparison. 
  • Risk of handling injectable antineoplastic agents. 
  • Stimulation of mutations suppressing the loss of replication control by small alcohols. 
  • Study of the ability of phenacetin, acetaminophen, and aspirin to induce cytotoxicity, mutation, and morphological transformation in C3H/10T1/2 clone 8 mouse embryo cells. 
  • Tissue- and strain-specific effects of a genotoxic carcinogen 1,3-butadiene on chromatin and transcription. 
  • Transfection of a human cytochrome P-450 gene into the human lymphoblastoid cell line, AHH-1, and use of the recombinant cell line in gene mutation assays. 
  • Transformation of rat tracheal epithelial cells to immortal growth variants by particulate and soluble nickel compounds. 
  • Weight of the evidence on the human carcinogenicity of 2,4-D. 
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  Keywords of People

  • Bennett, Vann, George B. Geller Professor for Research in Molecular Biology in the School of Medicine, Duke Cancer Institute
  • McConnell, Eleanor Schildwachter, Associate Professor in the School of Nursing, with tenure, School of Nursing