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Subject Areas on Research
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4-Nitroquinoline-1-oxide-induced mutagen sensitivity and risk of nonmelanoma skin cancer: a case-control analysis.
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4-nitroquinoline-1-oxide-induced mutagen sensitivity and risk of cutaneous melanoma: a case-control analysis.
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A guide for performing germ cell mutagenesis assays using Drosophila melanogaster.
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A preliminary investigation of the parallelogram concept in genetic monitoring and risk estimation.
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A sensitized mutagenesis screen identifies Gli3 as a modifier of Sox10 neurocristopathy.
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ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses.
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Acquisition of mitochondrial dysregulation and resistance to mitochondrial-mediated apoptosis after genotoxic insult in normal human fibroblasts: a possible model for early stage carcinogenesis.
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Adverse benzo[a]pyrene effects on neurodifferentiation are altered by other neurotoxicant coexposures: interactions with dexamethasone, chlorpyrifos, or nicotine in PC12 cells.
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Alterations in calcium metabolism in murine macrophages by the benzene metabolite 1,4-benzoquinone.
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Alternative splicing in Acad8 resulting a mitochondrial defect and progressive hepatic steatosis in mice.
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An N-ethyl-N-nitrosourea mutagenesis recessive screen identifies two candidate regions for murine cardiomyopathy that map to chromosomes 1 and 15.
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Analysis of gene mutations and clastogenicity following short-term treatment with azathioprine in MutaMouse.
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Association between family history of cancer and mutagen sensitivity in upper aerodigestive tract cancer patients.
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Bisulfite induces tandem double CC-->TT mutations in double-stranded DNA. 2. Kinetics of cytosine deamination.
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Caenorhabditis elegans as an emerging model system in environmental epigenetics.
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Caenorhabditis elegans generates biologically relevant levels of genotoxic metabolites from aflatoxin B1 but not benzo[a]pyrene in vivo.
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Caenorhabditis elegans: an emerging model in biomedical and environmental toxicology.
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Cell-enhanced dissolution of carcinogenic lead chromate particles: the role of individual dissolution products in clastogenesis.
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Chemical stability of metallic nanoparticles: a parameter controlling their potential cellular toxicity in vitro.
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Chromium (VI) at plausible drinking water concentrations is not genotoxic in the in vivo bone marrow micronucleus or liver unscheduled DNA synthesis assays.
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Chromium genotoxicity: A double-edged sword.
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Chromium(III) picolinate produces chromosome damage in Chinese hamster ovary cells.
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Chromosomes with high gene density are preferentially repaired in human cells.
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Clastogenicity of lead chromate particles in hamster and human cells.
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Comment on "Mutagenic Azo Dyes, Rather Than Flame Retardants, Are the Predominant Brominated Compounds in House Dust".
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Comparison of a chemical assay with a tissue-mediated bio-assay for chemical mutagens.
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Comparison of human and rat hepatocyte metabolism and mutagenic activation of 2-acetylaminofluorene.
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Complexities of chromium carcinogenesis: role of cellular response, repair and recovery mechanisms.
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Crystal structure of O4-methyl uridine: stacking induced changes in the geometry of the pyrimidine ring and its mutagenic role.
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Crystal structure of the promutagen O4-methylthymidine: importance of the anti conformation of the O(4) methoxy group and possible mispairing of O4-methylthymidine with guanine.
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DNA adduct formation by 12 chemicals with populations potentially suitable for molecular epidemiological studies.
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DNA repair phenotype and cancer susceptibility--a mini review.
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DNA repair: a double-edged sword.
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Data and animal management software for large-scale phenotype screening.
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Demonstrating mutagenicity using the Ames test.
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Dietary mutagen exposure and risk of pancreatic cancer.
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Dosimetry of the chemical mutagen ethyl methanesulfonate in spermatozoan DNA from Drosophila melanogaster.
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ENU mutagenesis identifies mice with mitochondrial branched-chain aminotransferase deficiency resembling human maple syrup urine disease.
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Effect of isopropyl-beta-D-thiogalactopyranosid induction of the lac operon on the specificity of spontaneous and doxorubicin-induced mutations in Escherichia coli.
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Effect of mutagen-induced cell lethality on the dose response of germline mutations.
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Effects of reduced mitochondrial DNA content on secondary mitochondrial toxicant exposure in Caenorhabditis elegans.
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Elevated frequencies of micronucleated erythrocytes in infants exposed to zidovudine in utero and postpartum to prevent mother-to-child transmission of HIV.
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Etiology of the mutational spectrum of ras genes in human carcinomas.
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Excision repair is required for genotoxin-induced mutagenesis in mammalian cells.
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Excision repair reduces doxorubicin-induced genotoxicity.
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Experimental and pan-cancer genome analyses reveal widespread contribution of acrylamide exposure to carcinogenesis in humans.
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Exposure to mitochondrial genotoxins and dopaminergic neurodegeneration in Caenorhabditis elegans.
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Expression of O6-methylguanine-DNA methyltransferase in malignant human glioma cell lines.
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Formaldehyde and leukemia: epidemiology, potential mechanisms, and implications for risk assessment.
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Frameshifts and deletions during in vitro translesion synthesis past Pt-DNA adducts by DNA polymerases beta and eta.
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GUCY2C opposes systemic genotoxic tumorigenesis by regulating AKT-dependent intestinal barrier integrity.
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Genetic susceptibility to lung cancer: the role of DNA damage and repair.
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Genetics and women's health issues--the commitment of EMS to women scientists and gender-associated disease topics.
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Genome-wide mutational signatures of aristolochic acid and its application as a screening tool.
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Imprinted genes as potential genetic and epigenetic toxicologic targets.
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In vitro and in vivo genotoxicity evaluation of hormonal drugs. I. Hydrocortisone.
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In vitro and in vivo genotoxicity evaluation of hormonal drugs. II. Dexamethasone.
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In vitro benzo[a]pyrene diol epoxide-induced DNA damage and chromosomal aberrations in primary lymphocytes, smoking, and risk of squamous cell carcinoma of the head and neck.
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In vitro interactions between DMSA-coated maghemite nanoparticles and human fibroblasts: A physicochemical and cyto-genotoxical study.
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Interaction of the cytochrome P4501A2, SULT1A1 and NAT gene polymorphisms with smoking and dietary mutagen intake in modification of the risk of pancreatic cancer.
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Interlaboratory validation of a new assay for DNA-protein crosslinks.
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International Commission for Protection Against Environmental Mutagens and Carcinogens. Mutagenicity and carcinogenicity of topoisomerase-interactive agents.
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Mechanistic insights into the cytotoxicity and genotoxicity induced by glycidamide in human mammary cells.
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Mitochondria as a target of environmental toxicants
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Molecular dosimetry of chemical mutagens. Determination of molecular dose to the germ line.
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Molecular dosimetry of the mutagen ethyl methanesulfonate in Drosophila melanogaster spermatozoa: linear relation of DNA alkylation per sperm cell (dose) to sex-linked recessive lethals.
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Mutagen sensitivity in upper aerodigestive tract cancer: a case-control analysis.
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Mutagenicity and carcinogenicity of biological reactive intermediate's derived from a "non-genotoxic" carcinogen.
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Mutation spectrum of 2-chloroethyl methanesulfonate in Drosophila melanogaster premeiotic germ cells.
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Nucleotide excision repair functions in the removal of chromium-induced DNA damage in mammalian cells.
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Permeability of latex and polyvinyl chloride gloves to 20 antineoplastic drugs.
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Permeability of latex and polyvinyl chloride gloves to carmustine.
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Projections of Drosophila multidendritic neurons in the central nervous system: links with peripheral dendrite morphology.
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Protonated base pairs explain the ambiguous pairing properties of O6-methylguanine.
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Rad18 confers hematopoietic progenitor cell DNA damage tolerance independently of the Fanconi Anemia pathway in vivo.
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Re-evaluation of urine mutagenicity of pharmacy personnel exposed to antineoplastic agents.
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Reduced DNA repair capacity in lung cancer patients.
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Reliability of mutagen sensitivity assay: an inter-laboratory comparison.
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Repetitive nonlethal oxidant injury to retinal pigment epithelium decreased extracellular matrix turnover in vitro and induced sub-RPE deposits in vivo.
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Reproduction and work.
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Resistance to apoptosis, increased growth potential, and altered gene expression in cells that survived genotoxic hexavalent chromium [Cr(VI)] exposure.
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Risk of handling injectable antineoplastic agents.
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Rsp5 ubiquitin-protein ligase mediates DNA damage-induced degradation of the large subunit of RNA polymerase II in Saccharomyces cerevisiae.
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Signal transduction. Three paths to stress relief.
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Soluble vs insoluble hexavalent chromate. Relationship of mutation to in vitro transformation and particle uptake.
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Study of the ability of phenacetin, acetaminophen, and aspirin to induce cytotoxicity, mutation, and morphological transformation in C3H/10T1/2 clone 8 mouse embryo cells.
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The GO system prevents ROS-induced mutagenesis and killing in Pseudomonas aeruginosa.
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The importance of molecular dosimetry and analysis of mutations for estimation of genetic risk.
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The mutagen and carcinogen cadmium is a high-affinity inhibitor of the zinc-dependent MutLα endonuclease.
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The sex-linked recessive lethal test for mutagenesis in Drosophila melanogaster. A report of the U.S. Environmental Protection Agency Gene-Tox Program.
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Transformation of rat tracheal epithelial cells to immortal growth variants by particulate and soluble nickel compounds.
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Tumor necrosis factor-alpha is a potent endogenous mutagen that promotes cellular transformation.
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Urinary mutagenicity and other biomarkers of occupational smoke exposure of wildland firefighters and oxidative stress.
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Variations in Prkdc and susceptibility to benzene-induced toxicity in mice.