Mutagens

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  Subject Areas on Research

  • 4-Nitroquinoline-1-oxide-induced mutagen sensitivity and risk of nonmelanoma skin cancer: a case-control analysis. 
  • 4-nitroquinoline-1-oxide-induced mutagen sensitivity and risk of cutaneous melanoma: a case-control analysis. 
  • A guide for performing germ cell mutagenesis assays using Drosophila melanogaster. 
  • A preliminary investigation of the parallelogram concept in genetic monitoring and risk estimation. 
  • A sensitized mutagenesis screen identifies Gli3 as a modifier of Sox10 neurocristopathy. 
  • ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses. 
  • Acquisition of mitochondrial dysregulation and resistance to mitochondrial-mediated apoptosis after genotoxic insult in normal human fibroblasts: a possible model for early stage carcinogenesis. 
  • Adverse benzo[a]pyrene effects on neurodifferentiation are altered by other neurotoxicant coexposures: interactions with dexamethasone, chlorpyrifos, or nicotine in PC12 cells. 
  • Alterations in calcium metabolism in murine macrophages by the benzene metabolite 1,4-benzoquinone. 
  • Alternative splicing in Acad8 resulting a mitochondrial defect and progressive hepatic steatosis in mice. 
  • An N-ethyl-N-nitrosourea mutagenesis recessive screen identifies two candidate regions for murine cardiomyopathy that map to chromosomes 1 and 15. 
  • Analysis of gene mutations and clastogenicity following short-term treatment with azathioprine in MutaMouse. 
  • Association between family history of cancer and mutagen sensitivity in upper aerodigestive tract cancer patients. 
  • Bisulfite induces tandem double CC-->TT mutations in double-stranded DNA. 2. Kinetics of cytosine deamination. 
  • Caenorhabditis elegans as an emerging model system in environmental epigenetics. 
  • Caenorhabditis elegans generates biologically relevant levels of genotoxic metabolites from aflatoxin B1 but not benzo[a]pyrene in vivo 
  • Caenorhabditis elegans: an emerging model in biomedical and environmental toxicology. 
  • Cell-enhanced dissolution of carcinogenic lead chromate particles: the role of individual dissolution products in clastogenesis. 
  • Characterization of colibactin-associated mutational signature in an Asian oral squamous cell carcinoma and in other mucosal tumor types. 
  • Chemical stability of metallic nanoparticles: a parameter controlling their potential cellular toxicity in vitro. 
  • Chromium (VI) at plausible drinking water concentrations is not genotoxic in the in vivo bone marrow micronucleus or liver unscheduled DNA synthesis assays. 
  • Chromium genotoxicity: A double-edged sword. 
  • Chromium(III) picolinate produces chromosome damage in Chinese hamster ovary cells. 
  • Chromosomes with high gene density are preferentially repaired in human cells. 
  • Clastogenicity of lead chromate particles in hamster and human cells. 
  • CometChip enables parallel analysis of multiple DNA repair activities. 
  • Comment on "Mutagenic Azo Dyes, Rather Than Flame Retardants, Are the Predominant Brominated Compounds in House Dust". 
  • Comparison of a chemical assay with a tissue-mediated bio-assay for chemical mutagens. 
  • Comparison of human and rat hepatocyte metabolism and mutagenic activation of 2-acetylaminofluorene. 
  • Complexities of chromium carcinogenesis: role of cellular response, repair and recovery mechanisms. 
  • Crystal structure of O4-methyl uridine: stacking induced changes in the geometry of the pyrimidine ring and its mutagenic role. 
  • Crystal structure of the promutagen O4-methylthymidine: importance of the anti conformation of the O(4) methoxy group and possible mispairing of O4-methylthymidine with guanine. 
  • DNA adduct formation by 12 chemicals with populations potentially suitable for molecular epidemiological studies. 
  • DNA repair phenotype and cancer susceptibility--a mini review. 
  • DNA repair: a double-edged sword. 
  • Data and animal management software for large-scale phenotype screening. 
  • Dietary mutagen exposure and risk of pancreatic cancer. 
  • Dosimetry of the chemical mutagen ethyl methanesulfonate in spermatozoan DNA from Drosophila melanogaster. 
  • ENU mutagenesis identifies mice with mitochondrial branched-chain aminotransferase deficiency resembling human maple syrup urine disease. 
  • Effect of isopropyl-beta-D-thiogalactopyranosid induction of the lac operon on the specificity of spontaneous and doxorubicin-induced mutations in Escherichia coli. 
  • Effect of mutagen-induced cell lethality on the dose response of germline mutations. 
  • Effects of reduced mitochondrial DNA content on secondary mitochondrial toxicant exposure in Caenorhabditis elegans. 
  • Elevated frequencies of micronucleated erythrocytes in infants exposed to zidovudine in utero and postpartum to prevent mother-to-child transmission of HIV. 
  • Etiology of the mutational spectrum of ras genes in human carcinomas. 
  • Excision repair is required for genotoxin-induced mutagenesis in mammalian cells. 
  • Excision repair reduces doxorubicin-induced genotoxicity. 
  • Experimental and pan-cancer genome analyses reveal widespread contribution of acrylamide exposure to carcinogenesis in humans. 
  • Exposure to mitochondrial genotoxins and dopaminergic neurodegeneration in Caenorhabditis elegans. 
  • Expression of O6-methylguanine-DNA methyltransferase in malignant human glioma cell lines. 
  • Formaldehyde and leukemia: epidemiology, potential mechanisms, and implications for risk assessment. 
  • Frameshifts and deletions during in vitro translesion synthesis past Pt-DNA adducts by DNA polymerases beta and eta. 
  • GUCY2C opposes systemic genotoxic tumorigenesis by regulating AKT-dependent intestinal barrier integrity. 
  • Genetic susceptibility to lung cancer: the role of DNA damage and repair. 
  • Genetics and women's health issues--the commitment of EMS to women scientists and gender-associated disease topics. 
  • Genome-wide mutational signatures of aristolochic acid and its application as a screening tool. 
  • Imprinted genes as potential genetic and epigenetic toxicologic targets. 
  • In vitro and in vivo genotoxicity evaluation of hormonal drugs. I. Hydrocortisone. 
  • In vitro and in vivo genotoxicity evaluation of hormonal drugs. II. Dexamethasone. 
  • In vitro benzo[a]pyrene diol epoxide-induced DNA damage and chromosomal aberrations in primary lymphocytes, smoking, and risk of squamous cell carcinoma of the head and neck. 
  • In vitro interactions between DMSA-coated maghemite nanoparticles and human fibroblasts: A physicochemical and cyto-genotoxical study. 
  • Interaction of the cytochrome P4501A2, SULT1A1 and NAT gene polymorphisms with smoking and dietary mutagen intake in modification of the risk of pancreatic cancer. 
  • Interlaboratory validation of a new assay for DNA-protein crosslinks. 
  • International Commission for Protection Against Environmental Mutagens and Carcinogens. Mutagenicity and carcinogenicity of topoisomerase-interactive agents. 
  • Mechanistic insights into the cytotoxicity and genotoxicity induced by glycidamide in human mammary cells. 
  • Mitochondria as a target of environmental toxicants 
  • Molecular dosimetry of chemical mutagens. Determination of molecular dose to the germ line. 
  • Molecular dosimetry of the mutagen ethyl methanesulfonate in Drosophila melanogaster spermatozoa: linear relation of DNA alkylation per sperm cell (dose) to sex-linked recessive lethals. 
  • Mutagen sensitivity in upper aerodigestive tract cancer: a case-control analysis. 
  • Mutagenicity and carcinogenicity of biological reactive intermediate's derived from a "non-genotoxic" carcinogen. 
  • Mutation spectrum of 2-chloroethyl methanesulfonate in Drosophila melanogaster premeiotic germ cells. 
  • Nucleotide excision repair functions in the removal of chromium-induced DNA damage in mammalian cells. 
  • Projections of Drosophila multidendritic neurons in the central nervous system: links with peripheral dendrite morphology. 
  • Protonated base pairs explain the ambiguous pairing properties of O6-methylguanine. 
  • Rad18 confers hematopoietic progenitor cell DNA damage tolerance independently of the Fanconi Anemia pathway in vivo. 
  • Reduced DNA repair capacity in lung cancer patients. 
  • Reliability of mutagen sensitivity assay: an inter-laboratory comparison. 
  • Repetitive nonlethal oxidant injury to retinal pigment epithelium decreased extracellular matrix turnover in vitro and induced sub-RPE deposits in vivo. 
  • Reproduction and work. 
  • Resistance to apoptosis, increased growth potential, and altered gene expression in cells that survived genotoxic hexavalent chromium [Cr(VI)] exposure. 
  • Rsp5 ubiquitin-protein ligase mediates DNA damage-induced degradation of the large subunit of RNA polymerase II in Saccharomyces cerevisiae. 
  • Signal transduction. Three paths to stress relief. 
  • Soluble vs insoluble hexavalent chromate. Relationship of mutation to in vitro transformation and particle uptake. 
  • Study of the ability of phenacetin, acetaminophen, and aspirin to induce cytotoxicity, mutation, and morphological transformation in C3H/10T1/2 clone 8 mouse embryo cells. 
  • The GO system prevents ROS-induced mutagenesis and killing in Pseudomonas aeruginosa. 
  • The importance of molecular dosimetry and analysis of mutations for estimation of genetic risk. 
  • The mutagen and carcinogen cadmium is a high-affinity inhibitor of the zinc-dependent MutLα endonuclease. 
  • The sex-linked recessive lethal test for mutagenesis in Drosophila melanogaster. A report of the U.S. Environmental Protection Agency Gene-Tox Program. 
  • Toward clinical understanding of aristolochic acid upper-tract urothelial carcinoma. 
  • Transformation of rat tracheal epithelial cells to immortal growth variants by particulate and soluble nickel compounds. 
  • Tumor necrosis factor-alpha is a potent endogenous mutagen that promotes cellular transformation. 
  • Urinary mutagenicity and other biomarkers of occupational smoke exposure of wildland firefighters and oxidative stress. 
  • Variations in Prkdc and susceptibility to benzene-induced toxicity in mice.