Mycobacterium tuberculosis

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  Subject Areas on Research

  • A Deep Learning Approach to Antibiotic Discovery. 
  • A computational analysis of antisense off-targets in prokaryotic organisms. 
  • A critical role for CD8 T cells in a nonhuman primate model of tuberculosis. 
  • A long-acting formulation of rifabutin is effective for prevention and treatment of Mycobacterium tuberculosis. 
  • A randomized controlled trial of standard versus intensified tuberculosis diagnostics on treatment decisions by physicians in Northern Tanzania. 
  • Advances in basic and translational tuberculosis research: Proceedings of the first meeting of RePORT international. 
  • Adventures within the speckled band: heterogeneity, angiogenesis, and balanced inflammation in the tuberculous granuloma. 
  • Alpha-melanocyte-stimulating hormone suppresses antigen-stimulated T cell production of gamma-interferon. 
  • An ancestral mycobacterial effector promotes dissemination of infection. 
  • An explant technique for high-resolution imaging and manipulation of mycobacterial granulomas. 
  • Application of lipoarabinomannan antigen in tuberculosis diagnostics: current evidence. 
  • Assembly dynamics of Mycobacterium tuberculosis FtsZ. 
  • Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. 
  • Bacteremic disseminated tuberculosis in sub-saharan Africa: a prospective cohort study. 
  • Bacterial infection remodels the DNA methylation landscape of human dendritic cells. 
  • Building a tuberculosis-free world: The Lancet Commission on tuberculosis. 
  • CLARITY and PACT-based imaging of adult zebrafish and mouse for whole-animal analysis of infections. 
  • Causes of death on antiretroviral therapy: a post-mortem study from South Africa. 
  • Chemoinformatic identification of novel inhibitors against Mycobacterium tuberculosis L-aspartate α-decarboxylase. 
  • Clinical usefulness of detecting growth of Mycobacterium tuberculosis in positive Bactec phials using PCR. 
  • Common Variants in the Glycerol Kinase Gene Reduce Tuberculosis Drug Efficacy. 
  • Comparative pathogenesis of Mycobacterium marinum and Mycobacterium tuberculosis. 
  • Comparison of altitude effect on Mycobacterium tuberculosis infection between rural and urban communities in Peru. 
  • Comparison of methods based on different molecular epidemiological markers for typing of Mycobacterium tuberculosis complex strains: interlaboratory study of discriminatory power and reproducibility. 
  • Complex transmission dynamics of clonally related virulent Mycobacterium tuberculosis associated with barhopping by predominantly human immunodeficiency virus-positive gay men. 
  • Concordance of Drug-resistance Profiles Between Persons With Drug-resistant Tuberculosis and Their Household Contacts: A Systematic Review and Meta-analysis. 
  • Controlled comparison of BacT/Alert MB system, manual Myco/F lytic procedure, and isolator 10 system for diagnosis of Mycobacterium tuberculosis Bacteremia. 
  • Cost-effectiveness analysis of the gen-probe amplified mycobacterium tuberculosis direct test as used routinely on smear-positive respiratory specimens. 
  • Cross-protective immunity to porcine reproductive and respiratory syndrome virus by intranasal delivery of a live virus vaccine with a potent adjuvant. 
  • Current issues in global tuberculosis control. 
  • Cycloserine and Linezolid for Tuberculosis Meningitis: Pharmacokinetic Evidence of Potential Usefulness. 
  • Cytokine production induced by Mycobacterium tuberculosis lipoarabinomannan. Relationship to chemical structure. 
  • Decoding the tuberculous granuloma. 
  • Deficiency of double-strand DNA break repair does not impair Mycobacterium tuberculosis virulence in multiple animal models of infection. 
  • Design, synthesis, and study of a mycobactin-artemisinin conjugate that has selective and potent activity against tuberculosis and malaria. 
  • Detection of bloodstream pathogens in a bacille Calmette-Guérin (BCG)-vaccinated pediatric population in Malawi: a pilot study. 
  • Diagnostic accuracy of C-reactive protein for active pulmonary tuberculosis: a meta-analysis. 
  • Different methods of sample preparation influence sensitivity of Mycobacterium tuberculosis and Borrelia burgdorferi PCR. 
  • Differential Requirement for IRGM Proteins during Tuberculosis Infection in Mice. 
  • Differentiation of strains in Mycobacterium tuberculosis complex by DNA sequence polymorphisms, including rapid identification of M. bovis BCG. 
  • Diguanidino and "reversed" diamidino 2,5-diarylfurans as antimicrobial agents. 
  • Discriminating between latent and active tuberculosis with multiple biomarker responses. 
  • Discrimination of Mycobacterium tuberculosis strains by PCR. 
  • Efficacy and safety of live attenuated persistent and rapidly cleared Mycobacterium tuberculosis vaccine candidates in non-human primates. 
  • Efficacy and safety of three antiretroviral regimens for initial treatment of HIV-1: a randomized clinical trial in diverse multinational settings. 
  • Enhanced priming of adaptive immunity by Mycobacterium smegmatis mutants with high-level protein secretion. 
  • Evaluating latent tuberculosis infection diagnostics using latent class analysis. 
  • Evaluation of the Vitek MS v3.0 Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry System for Identification of Mycobacterium and Nocardia Species. 
  • Evolutionary bottlenecks in the agents of tuberculosis, leprosy, and paratuberculosis. 
  • Exogenous reinfection of tuberculosis in a low-burden area. 
  • Extensive DNA sequence conservation throughout the Mycobacterium tuberculosis complex. 
  • Extensive phosphorylation with overlapping specificity by Mycobacterium tuberculosis serine/threonine protein kinases. 
  • Fever and human immunodeficiency virus infection as sentinels for emerging mycobacterial and fungal bloodstream infections in hospitalized patients >/=15 years old, Bangkok. 
  • Fit for consumption: zebrafish as a model for tuberculosis. 
  • Functionally Overlapping Variants Control Tuberculosis Susceptibility in Collaborative Cross Mice. 
  • GeneXpert MTB/Rif to Diagnose Tuberculous Meningitis: Perhaps the First Test but not the Last. 
  • Genetic diversity in the Mycobacterium tuberculosis complex based on variable numbers of tandem DNA repeats. 
  • Genomic sequencing is required for identification of tuberculosis transmission in Hawaii. 
  • Genotypic and Spatial Analysis of Mycobacterium tuberculosis Transmission in a High-Incidence Urban Setting. 
  • Granulocytes act as a niche for Mycobacterium tuberculosis growth. 
  • High-throughput identification and dendritic cell-based functional validation of MHC class I-restricted Mycobacterium tuberculosis epitopes. 
  • Hospital management of tuberculosis in a region with a low incidence of tuberculosis and a high prevalence of nontuberculous mycobacteria. 
  • Host-Directed Therapies for Tuberculosis. 
  • Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice. 
  • Hypothesis: is lung disease after silicate inhalation caused by oxidant generation? 
  • IL-17 Production of Neutrophils Enhances Antibacteria Ability but Promotes Arthritis Development During Mycobacterium tuberculosis Infection. 
  • Identification and evolution of an IS6110 low-copy-number Mycobacterium tuberculosis cluster. 
  • Identification of a W variant outbreak of Mycobacterium tuberculosis via population-based molecular epidemiology. 
  • Imaging of bacterial pulmonary infection in the immunocompetent patient. 
  • Immune control of tuberculosis by IFN-gamma-inducible LRG-47. 
  • Immune distribution and localization of phosphoantigen-specific Vgamma2Vdelta2 T cells in lymphoid and nonlymphoid tissues in Mycobacterium tuberculosis infection. 
  • Influence of M. tuberculosis lineage variability within a clinical trial for pulmonary tuberculosis. 
  • Innate inhibition of adaptive immunity: Mycobacterium tuberculosis-induced IL-6 inhibits macrophage responses to IFN-gamma. 
  • Interleukin 12 at the site of disease in tuberculosis. 
  • Intranasal delivery of an adjuvanted modified live porcine reproductive and respiratory syndrome virus vaccine reduces ROS production. 
  • Intranasal delivery of whole cell lysate of Mycobacterium tuberculosis induces protective immune responses to a modified live porcine reproductive and respiratory syndrome virus vaccine in pigs. 
  • Intravitreal sustained-release cyclosporine in the treatment of experimental uveitis. 
  • Intravitreal sustained-release dexamethasone device in the treatment of experimental uveitis. 
  • Inverse correlation of maturity and antibacterial activity in human dendritic cells. 
  • Just say NO to NLRP3. 
  • Knowns and unknowns of membrane lipid synthesis in streptomycetes. 
  • M. tuberculosis-Initiated Human Mannose Receptor Signaling Regulates Macrophage Recognition and Vesicle Trafficking by FcRγ-Chain, Grb2, and SHP-1. 
  • Macrophage Epithelial Reprogramming Underlies Mycobacterial Granuloma Formation and Promotes Infection. 
  • Macrophage NFATC2 mediates angiogenic signaling during mycobacterial infection. 
  • Macrophage form, function, and phenotype in mycobacterial infection: lessons from tuberculosis and other diseases. 
  • Macrophage immunoregulatory pathways in tuberculosis. 
  • Mast cell activation by Mycobacterium tuberculosis: mediator release and role of CD48. 
  • Medium matters: modeling the impact of solid medium performance on tuberculosis trial sample size requirements. 
  • Mice deficient in LRG-47 display increased susceptibility to mycobacterial infection associated with the induction of lymphopenia. 
  • Modeling Diversity: Do Homogeneous Laboratory Strains Limit Discovery? 
  • Modulation of Human Macrophage Responses to Mycobacterium tuberculosis by Silver Nanoparticles of Different Size and Surface Modification. 
  • Molecular Diagnostics for Mycobacterium tuberculosis Infection. 
  • Molecular epidemiology and tuberculosis control. 
  • Molecular identification of streptomycin monoresistant Mycobacterium tuberculosis related to multidrug-resistant W strain. 
  • MxA suppresses TAK1-IKKα/β-NF-κB mediated inflammatory cytokine production to facilitate Mycobacterium tuberculosis infection. 
  • Mycobacteria manipulate macrophage recruitment through coordinated use of membrane lipids. 
  • Mycobacterial Evolution Intersects With Host Tolerance. 
  • Mycobacterial Mutagenesis and Drug Resistance Are Controlled by Phosphorylation- and Cardiolipin-Mediated Inhibition of the RecA Coprotease. 
  • Mycobacterial esophagitis in AIDS. 
  • Mycobacterial infection aggravates Helicobacter pylori-induced gastric preneoplastic pathology by redirection of de novo induced Treg cells. 
  • Mycobacterial interspersed repetitive-unit-variable-number tandem-repeat analysis and Beijing/W family of Mycobacterium tuberculosis. 
  • Mycobacterium tuberculosis Beijing family: analysis of the epidemiological and clinical factors associated with an emerging lineage in the urban area of Milan. 
  • Mycobacterium tuberculosis Evasion of Guanylate Binding Protein-Mediated Host Defense in Mice Requires the ESX1 Secretion System. 
  • Mycobacterium tuberculosis decreases human macrophage IFN-γ responsiveness through miR-132 and miR-26a. 
  • Mycobacterium tuberculosis in lung transplant recipients. 
  • Mycobacterium tuberculosis infection induces il12rb1 splicing to generate a novel IL-12Rbeta1 isoform that enhances DC migration. 
  • Mycobacterium tuberculosis lipomannan blocks TNF biosynthesis by regulating macrophage MAPK-activated protein kinase 2 (MK2) and microRNA miR-125b. 
  • Mycobacterium tuberculosis polymerase chain reaction findings in neurosarcoidosis. 
  • Mycobacterium tuberculosis whole cell lysate enhances proliferation of CD8 positive lymphocytes and nitric oxide secretion in the lungs of live porcine respiratory and reproductive syndrome virus vaccinated pigs. 
  • NLRC3 negatively regulates CD4+ T cells and impacts protective immunity during Mycobacterium tuberculosis infection. 
  • Negative-stain electron microscopy of inside-out FtsZ rings reconstituted on artificial membrane tubules show ribbons of protofilaments. 
  • Nitric oxide prevents a pathogen-permissive granulocytic inflammation during tuberculosis. 
  • Novel Regimens of Bedaquiline-Pyrazinamide Combined with Moxifloxacin, Rifabutin, Delamanid and/or OPC-167832 in Murine Tuberculosis Models. 
  • PCR identification of Mycobacterium bovis BCG. 
  • PET appearance of tuberculous empyema necessitans. 
  • Pairing QuantiFERON gold in-tube with opt-out HIV testing in a tuberculosis contact investigation in the Southeastern United States. 
  • Performance of Homologous and Heterologous Prime-Boost Immunization Regimens of Recombinant Adenovirus and Modified Vaccinia Virus Ankara Expressing an Ag85B-TB10.4 Fusion Protein against Mycobacterium tuberculosis. 
  • Performance of Xpert Ultra nasopharyngeal swab for identification of tuberculosis deaths in northern Tanzania. 
  • Performance of nucleic acid amplification following extraction of 5 milliliters of whole blood for diagnosis of Mycobacterium tuberculosis bacteremia. 
  • Periprosthetic infections due to Mycobacterium tuberculosis in patients with no prior history of tuberculosis. 
  • Phenotypic and genotypic characterization of Mycobacterium africanum isolates from West Africa. 
  • Policy changes and the screening, diagnosis and treatment of drug-resistant tuberculosis patients from 2015 to 2018 in Zhejiang Province, China: a retrospective cohort study. 
  • Potentiation of P2RX7 as a host-directed strategy for control of mycobacterial infection. 
  • Predictors and outcomes of Mycobacterium tuberculosis bacteremia among patients with HIV and tuberculosis co-infection enrolled in the ACTG A5221 STRIDE study. 
  • Presumptive diagnosis and treatment of pulmonary tuberculosis based on radiographic findings. 
  • Prevalence of mycobacteremia among HIV-infected infants and children in northern Tanzania. 
  • Pulmonary immune-compartment-specific interferon gamma responses in HIV-infected individuals with active tuberculosis (TB) in an area of high TB prevalence. 
  • Pyrazinamide and pyrazinoic acid activity against tubercle bacilli in cultured human macrophages and in the BACTEC system. 
  • Rapid identification of laboratory contamination with Mycobacterium tuberculosis using variable number tandem repeat analysis. 
  • Rapid molecular detection of tuberculosis and rifampin resistance. 
  • Rapid radiometric method for pyrazinamide susceptibility testing of Mycobacterium tuberculosis. 
  • Reduced virulence of an extensively drug-resistant outbreak strain of Mycobacterium tuberculosis in a murine model. 
  • Reliability of cord formation in BACTEC media for presumptive identification of mycobacteria. 
  • SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues. 
  • Sacral tuberculosis: a case report and review of the literature. 
  • Search for microRNAs expressed by intracellular bacterial pathogens in infected mammalian cells. 
  • Season and size of urban particulate matter differentially affect cytotoxicity and human immune responses to Mycobacterium tuberculosis. 
  • Seasonal variation in the etiology of bloodstream infections in a febrile inpatient population in a developing country. 
  • Simultaneous genotyping and species identification using hybridization pattern recognition analysis of generic Mycobacterium DNA arrays. 
  • Statistical analysis of genetic interactions in Tn-Seq data. 
  • Statistical analysis of variability in TnSeq data across conditions using zero-inflated negative binomial regression. 
  • Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13. 
  • Substitution of moxifloxacin for isoniazid during intensive phase treatment of pulmonary tuberculosis. 
  • Substitution of rifapentine for rifampin during intensive phase treatment of pulmonary tuberculosis: study 29 of the tuberculosis trials consortium. 
  • Successful cure of extensively drug-resistant pulmonary tuberculosis in a young child. 
  • Suppression of the NF-κB pathway by diesel exhaust particles impairs human antimycobacterial immunity. 
  • Suprastructures and dynamic properties of Mycobacterium tuberculosis FtsZ. 
  • Sustained activation of mTORC1 in macrophages increases AMPKα-dependent autophagy to maintain cellular homeostasis. 
  • T Cell Responses against Mycobacterial Lipids and Proteins Are Poorly Correlated in South African Adolescents. 
  • T cell activation within different intraocular compartments during experimental uveitis. 
  • The Mycobacterium tuberculosis 71-kDa heat-shock protein induces proliferation and cytokine secretion by murine gut intraepithelial lymphocytes. 
  • The Phagocyte Oxidase Controls Tolerance to Mycobacterium tuberculosis Infection. 
  • The complexities of Xpert® MTB/RIF interpretation. 
  • The evolution of drug resistance in Mycobacterium tuberculosis: from a mono-rifampin-resistant cluster into increasingly multidrug-resistant variants in an HIV-seropositive population. 
  • The hidden hypothesis: A disseminated tuberculosis case. 
  • The human antibody response to the surface of Mycobacterium tuberculosis. 
  • The risks and benefits of childhood bacille Calmette-Guérin immunization among adults with AIDS. International MAC study groups. 
  • Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease. 
  • Thermal stability of self-assembled peptide vaccine materials. 
  • Tissue plasminogen activator (tPA) signal sequence enhances immunogenicity of MVA-based vaccine against tuberculosis. 
  • Transmission Of Tuberculosis Among illicit drug use Linkages (TOTAL): A cross-sectional observational study protocol using respondent driven sampling. 
  • Treatment of tuberculosis in patients with advanced human immunodeficiency virus infection. 
  • Tuberculosis Susceptibility and Vaccine Protection Are Independently Controlled by Host Genotype. 
  • Tuberculosis and AIDS. 
  • Tuberculosis transmission from a patient with skin lesions and a negative sputum smear. 
  • Tuberculous granuloma induction via interaction of a bacterial secreted protein with host epithelium. 
  • Tumor necrosis factor-alpha antagonists for the treatment of rheumatic diseases. 
  • Ultra-low dose of Mycobacterium tuberculosis aerosol creates partial infection in mice. 
  • Understanding the costs of better tuberculosis diagnostics. 
  • United States geographic bacteria susceptibility patterns. 1996 ASCP Susceptibility Testing Group. American Society of Clinical Pathologists. 
  • Unrecognised Mycobacterium tuberculosis bacteraemia among hospital inpatients in less developed countries. 
  • Unrecognised Mycobacterium tuberculosis. 
  • Urban airborne particle exposure impairs human lung and blood Mycobacterium tuberculosis immunity. 
  • Visualizing the dynamics of tuberculosis pathology using molecular imaging. 
  • Vitamin B1 Helps to Limit Mycobacterium tuberculosis Growth via Regulating Innate Immunity in a Peroxisome Proliferator-Activated Receptor-γ-Dependent Manner. 
  • Vitamin B5 Reduces Bacterial Growth via Regulating Innate Immunity and Adaptive Immunity in Mice Infected with Mycobacterium tuberculosis. 
  • Who Knew? Injectable TB Drugs Are Not Equal, Despite Drug Susceptibility Testing. 
  • Whole genome sequencing identifies circulating Beijing-lineage Mycobacterium tuberculosis strains in Guatemala and an associated urban outbreak. 
  • mTOR-regulated mitochondrial metabolism limits mycobacterium-induced cytotoxicity. 
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  Keywords of People

  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Ferrari, Guido, Professor in Surgery, Molecular Genetics and Microbiology
  • Taylor, Gregory Alan, Professor in Medicine, Integrative Immunobiology