Myocardial Contraction

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  Subject Areas on Research

  • "Targeting the Heart" in Heart Failure: Myocardial Recovery in Heart Failure With Reduced Ejection Fraction. 
  • 3D cardiac μtissues within a microfluidic device with real-time contractile stress readout. 
  • A bolus dose of 1.5 mg/kg amrinone effectively improves low cardiac output state following separation from cardiopulmonary bypass in cardiac surgical patients. 
  • A comparison of real-time, two dimensional echocardiography and cineangiography in detecting left ventricular asynergy. 
  • A fully automated method for late ventricular diastole frame selection in post-dive echocardiography without ECG gating. 
  • A mathematical model for analysis of pharmacologically induced changes in the kinetics of cardiac muscle. 
  • A method to measure myocardial calcium handling in adult Drosophila. 
  • A noninvasive radiographic technique for evaluation of exercise-induced changes in cardiac function. 
  • A phantom for testing ECG-gated computed tomography of the heart. 
  • A resistor interpretation of general anisotropic cardiac tissue. 
  • A role for Sfrp2 in cardiomyogenesis in vivo. 
  • AT1 blockade prevents glucose-induced cardiac dysfunction in ventricular myocytes: role of the AT1 receptor and NADPH oxidase. 
  • Abi3bp regulates cardiac progenitor cell proliferation and differentiation. 
  • Abnormal cardiac function in the streptozotocin-induced non-insulin-dependent diabetic rat: noninvasive assessment with doppler echocardiography and contribution of the nitric oxide pathway. 
  • Acoustic radiation force-driven assessment of myocardial elasticity using the displacement ratio rate (DRR) method. 
  • Acquired dynamic left ventricular outflow tract obstruction complicating acute anterior myocardial infarction: serial echocardiographic and clinical evaluation. 
  • Acute Treatment With Omecamtiv Mecarbil to Increase Contractility in Acute Heart Failure: The ATOMIC-AHF Study. 
  • Acute functional consequences of left ventriculotomy. 
  • Acute ventricular wall motion heterogeneity. A valuable but imperfect index of myocardial ischemia. 
  • Adenovirus-mediated gene transfer of the beta2-adrenergic receptor to donor hearts enhances cardiac function. 
  • Adenovirus-mediated genetic manipulation of the myocardial beta-adrenergic signaling system in transplanted hearts. 
  • Alterations in diastolic function in response to progressive left ventricular hypertrophy. 
  • Alterations in hemodynamics and left ventricular contractility during carbon dioxide pneumoperitoneum. 
  • An upper limit for the electrogenic Na-K pump contribution to maximum diastolic potential in feline cardiac Purkinje fibers in steady state. 
  • Analysis of myocardial function in orthotopic cardiac allografts after prolonged storage in UW solution. 
  • Anaylsis of ventricular activation and repolarization from intramural and epicardial potential distributions for ectopic beats in the intact dog. 
  • Angiogenic potential of perivascularly delivered aFGF in a porcine model of chronic myocardial ischemia. 
  • Angiotensin as local modulating factor in ventricular dysfunction and failure due to coronary artery disease. 
  • Ankyrin-B syndrome: enhanced cardiac function balanced by risk of cardiac death and premature senescence. 
  • Ankyrin-B targets beta2-spectrin to an intracellular compartment in neonatal cardiomyocytes. 
  • Assessment of anatomy and cardiac function by Doppler echocardiography. 
  • Assessment of dexrazoxane as a cardioprotectant in doxorubicin-treated children with high-risk acute lymphoblastic leukaemia: long-term follow-up of a prospective, randomised, multicentre trial. 
  • Assessment of left ventricular functional preservation during isolated cardiac valve operations. 
  • Assessment of left ventricular pressure-volume relations using gated radionuclide angiography, echocardiography, and micromanometer pressure recordings. A new method for serial measurements of systolic and diastolic function in man. 
  • Assessment of regional wall motion abnormalities with real-time 3-dimensional echocardiography. 
  • Assessment of the intrinsic contractile status of the heart during sepsis by myocardial pressure-dimension analysis. 
  • Assessment of the myocardium on 2-phase cardiac multidetector computed tomography: does cyclic cardiac contraction influence myocardial attenuation? 
  • Assessment of the use of the age- and sex-specific United States population as a control group for analysis of survival in coronary artery disease. 
  • Atrial natriuretic factor may mediate the renal effects of PEEP ventilation. 
  • Augmentation of cardiac contractility mediated by the human beta(3)-adrenergic receptor overexpressed in the hearts of transgenic mice. 
  • Beta adrenergic blockade with propranolol and atenolol in the exercising dog: evidence for beta 2 adrenoceptors in the sinoatrial node. 
  • Beta(2)-adrenergic and several other G protein-coupled receptors in human atrial membranes activate both G(s) and G(i). 
  • Beta-adrenergic receptor desensitization in cardiac hypertrophy and heart failure. 
  • Beta1-adrenergic receptors stimulate cardiac contractility and CaMKII activation in vivo and enhance cardiac dysfunction following myocardial infarction. 
  • Biological evaluation of some terphenyl analogs of hemicholinium No. 3. 
  • Biosensibility of viability: NOGA or no good? 
  • Bistability and correlation with arrhythmogenesis in a model of the right atrium. 
  • Boosting cardiac contractility with genes. 
  • Brain death further promotes ischemic reperfusion injury of the rabbit myocardium. 
  • Calcitonin gene-related peptide enhances the recovery of contractile function in stunned myocardium. 
  • Calcium signaling regulates ventricular hypertrophy during development independent of contraction or blood flow. 
  • Calmodulin regulation of excitation-contraction coupling in cardiac myocytes. 
  • Candesartan in heart failure--assessment of reduction in mortality and morbidity (CHARM): rationale and design. Charm-Programme Investigators. 
  • Cardiac Myosin Activation with Omecamtiv Mecarbil in Systolic Heart Failure. 
  • Cardiac and muscle fatigue due to relative functional overload induced by excessive stimulation, hypersensitive excitation-contraction coupling, or diminished performance capacity correlates with sarcoplasmic reticulum failure. 
  • Cardiac contractility modulation: the next cardiac resynchronization therapy or another renal sympathetic denervation? 
  • Cardiac fatigue after prolonged exercise. 
  • Cardiac function in alcohol-associated systemic hypertension. 
  • Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor. 
  • Cardiac mechanics: basic and clinical contemporary research. 
  • Cardiac renin-angiotensin system. Molecular and functional aspects. 
  • Cardiac responses to the intrapericardial delivery of metoprolol: targeted delivery compared to intravenous administration. 
  • Cardiac troponin T and I, echocardiographic [correction of electrocardiographic] wall motion analyses, and ejection fractions in athletes participating in the Hawaii Ironman Triathlon. 
  • Cardiac-specific overexpression of angiotensin II AT2 receptor causes attenuated response to AT1 receptor-mediated pressor and chronotropic effects. 
  • Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues. 
  • Cardiotonic agents. 8. Selective inhibitors of adenosine 3',5'-cyclic phosphate phosphodiesterase III. Elaboration of a five-point model for positive inotropic activity. 
  • Cardiovascular and neuromuscular effects of dimethyl sulfoxide in anesthetized rabbits. 
  • Cardiovascular reactivity assessment: effects of choice of difficulty on laboratory task responses. 
  • Central hemodynamic effects of an oxytocin receptor antagonist (atosiban) in the isolated, perfused rat heart. 
  • Central venous pressure monitoring: clinical insights beyond the numbers. 
  • Changes in Left Ventricular Mechanics After Sleeve Gastrectomy. 
  • Changes in left ventricular systolic performance immediately after percutaneous aortic balloon valvuloplasty. 
  • Changing diastolic closure rates (E to F slopes) in a patient with mitral stenosis: a case report. 
  • Characteristics of chronic left ventricular hypertrophy induced by subcoronary valvular aortic stenosis. II. Response to ischemia. 
  • Characterization of cardiac dysfunction in sepsis: an ongoing challenge. 
  • Chronic N(G)-nitro-L-arginine methyl ester-induced hypertension : novel molecular adaptation to systolic load in absence of hypertrophy. 
  • Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy. 
  • Cine magnetic resonance microscopy of the rat heart using cardiorespiratory-synchronous projection reconstruction. 
  • Clinical Utility and Prognostic Value of Right Atrial Function in Pulmonary Hypertension. 
  • Clinical applications of coronary sinus retroperfusion during high risk percutaneous transluminal coronary angioplasty. 
  • Clinical assessment of diastolic function. 
  • Clinical assessment of ventricular ejection dynamics with and without outflow obstruction. 
  • Combined acetaldehyde and nicotine exposure depresses cardiac contraction in ventricular myocytes: prevention by folic acid. 
  • Comparative effects of lidocaine and procainamide on acutely impaired hemodynamics. 
  • Comparison of Clinical characteristics and long-term outcomes of patients with ischemic cardiomyopathy with versus without angina pectoris (from the Duke Databank for Cardiovascular Disease). 
  • Comparison of biplane and single plane left ventricular volumes in atrial septal defect. 
  • Comparison of echocardiographic methods for assessment of left ventricular shortening and wall stress. 
  • Comparison of magnetic resonance feature tracking for strain calculation with harmonic phase imaging analysis. 
  • Comparison of myocardial protection with nifedipine and potassium. 
  • Comparison of physiological motion filters for in vivo cardiac ARFI. 
  • Comparison of preload recruitable stroke work, end-systolic pressure-volume and dP/dtmax-end-diastolic volume relations as indexes of left ventricular contractile performance in patients undergoing routine cardiac catheterization. 
  • Complete reversal of ischemic wall motion abnormalities by combined use of gene therapy with transmyocardial laser revascularization. 
  • Computer-assisted modeling of blood-flow: theoretical evidence for the existence of optimal flow wave patterns. 
  • Contractile Fronts In The Interventricular Septum: A Case For High Frame Rate Echocardiographic Imaging. 
  • Contrast magnetic resonance imaging in the assessment of myocardial viability in patients with stable coronary artery disease and left ventricular dysfunction. 
  • Contribution of activation-inactivation dynamics to the impairment of relaxation in hypoxic cat papillary muscle. 
  • Control of myocardial contractile function by the level of beta-adrenergic receptor kinase 1 in gene-targeted mice. 
  • Coupled sodium-calcium transport in cultured chick heart cells. 
  • Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes. 
  • Creatine kinase overexpression improves ATP kinetics and contractile function in postischemic myocardium. 
  • Creatine kinase-mediated improvement of function in failing mouse hearts provides causal evidence the failing heart is energy starved. 
  • Cyclooxygenase-1 and -2 knockout mice demonstrate increased cardiac ischemia/reperfusion injury but are protected by acute preconditioning. 
  • Decreased beta-adrenergic responsiveness following hypertrophy occurs only in cardiomyocytes that also re-express beta-myosin heavy chain. 
  • Defective beta-adrenergic receptor signaling precedes the development of dilated cardiomyopathy in transgenic mice with calsequestrin overexpression. 
  • Defects in cardiomyocyte function: role of beta-adrenergic receptor dysfunction. 
  • Defibrillation and the geometry of the heart: a novel measurement with implications for defibrillation mechanisms. 
  • Defibrillation causes immediate cardiac dilation in humans. 
  • Delayed myocardial preconditioning by alpha1-adrenoceptors involves inhibition of apoptosis. 
  • Depletion of energy reserve via the creatine kinase reaction during the evolution of heart failure in cardiomyopathic hamsters. 
  • Design of an integrated sensor for in vivo simultaneous electrocontractile cardiac mapping. 
  • Detection, characterization and functional assessment of reperfused Q-wave acute myocardial infarction by cine magnetic resonance imaging. 
  • Development and cardiac contractility: cardiac troponin T isoforms and cytosolic calcium in rabbit. 
  • Developments in Exercise Capacity Assessment in Heart Failure Clinical Trials and the Rationale for the Design of METEORIC-HF. 
  • Diabetic cardiomyopathy and carnitine deficiency. 
  • Differences in exercising limb blood flow variability between cardiac and muscle contraction cycle related analysis during dynamic knee extensor. 
  • Different effects of prolonged exercise on the right and left ventricles. 
  • Differential cardiac effects of growth hormone and insulin-like growth factor-1 in the rat. A combined in vivo and in vitro evaluation. 
  • Differential ventricular ischemic injury: an experimental model of right ventricular failure with a variable degree of left ventricular dysfunction. 
  • Disproportionate effects of regional hypokinesis on radionuclide ejection fraction: compensation using attenuation-corrected ventricular volumes. 
  • Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice. 
  • Dissociation between global and regional systolic and diastolic ventricular function during coronary occlusion and reperfusion. 
  • Distinguishing mechanisms from markers of cardiac contractile dysfunction: more than 1 way to skin the cat of heart failure. 
  • Dobutamine stress echocardiography for preoperative cardiac risk stratification in patients undergoing orthotopic liver transplantation. 
  • Does anesthetic technique make a difference? Augmentation of systolic blood pressure during carotid endarterectomy: effects of phenylephrine versus light anesthesia and of isoflurane versus halothane on the incidence of myocardial ischemia. 
  • Does heart failure etiology, New York Heart Association class, or ejection fraction affect the ability of clopidogrel to inhibit heightened platelet activity? 
  • Does retinal vascular geometry vary with cardiac cycle? 
  • Doppler left ventricular diastolic filling abnormalities in aortic stenosis and their relation to hemodynamic parameters. 
  • Dual inhibition of beta-adrenergic and angiotensin II receptors by a single antagonist: a functional role for receptor-receptor interaction in vivo. 
  • Dual-interference-channel quantitative-phase microscopy of live cell dynamics. 
  • Dynamic culture yields engineered myocardium with near-adult functional output. 
  • Dynamic denitrosylation via S-nitrosoglutathione reductase regulates cardiovascular function. 
  • Dynamic mitral regurgitation without regional wall motion abnormality. 
  • Dynamic right ventricular dimension. Relation to chamber volume during the cardiac cycle. 
  • Dyssynchrony: a different kind of mitral regurgitation. 
  • Echocardiographic analysis of dysfunctional and normal myocardial segments before and immediately after coronary artery bypass graft surgery. 
  • Echocardiographic evaluation of tricuspid valve endocarditis: an M mode and two dimensional study. 
  • Echocardiographic evidence for impaired myocardial performance in children with type I diabetes mellitus. 
  • Echocardiographic findings in fulminant and acute myocarditis. 
  • Editorial: Diagnostic considerations in electromechanical dissociation. 
  • Effect of alpha-adrenergic stimulation on regional contractile function and myocardial blood flow with and without ischemia. 
  • Effect of p38 MAP kinases on contractility and ischemic injury in intact heart. 
  • Effect of rate-dependent left bundle branch block on global and regional left ventricular function. 
  • Effect of uniaxial, cyclic stretch on the morphology of monocytes/macrophages in culture. 
  • Effect of verapamil on left ventricular function at rest and during exercise in normal men. 
  • Effects of anaesthesia and recent surgery on diastolic function. 
  • Effects of barium-induced cardiac contraction on large- and small-vessel intramyocardial blood volume. 
  • Effects of breathing and cardiac motion on spatial resolution in the microscopic imaging of rodents. 
  • Effects of cardiac glycosides on atrial contractile dysfunction after short-term atrial fibrillation. 
  • Effects of delay in administration of potassium cardioplegia to the isolated rat heart. 
  • Effects of droperidol on depolarization-induced automaticity, maximum upstroke velocity (Vmax) and the kinetics of recovery of Vmax in guinea-pig ventricular myocardium. 
  • Effects of exercise training on ventricular function in patients with recent myocardial infarction. 
  • Effects of magnesium supplementation in a porcine model of myocardial ischemia and reperfusion. 
  • Effects of nitric oxide after cardiac transplantation in the setting of recipient pulmonary hypertension. 
  • Effects of physical conditioning on left ventricular ejection fraction in patients with coronary artery disease. 
  • Effects of standard mitral valve replacement on left ventricular function. 
  • Effects of steroids and angiotensin converting enzyme inhibition on circumferential strain in boys with Duchenne muscular dystrophy: a cross-sectional and longitudinal study utilizing cardiovascular magnetic resonance. 
  • Effects of stimulation frequency on potassium activity and cell volume in cardiac tissue. 
  • Effects of verapamil on postextrasystolic potentiation. 
  • Efficacy of intracoronary or intravenous VEGF165 in a pig model of chronic myocardial ischemia. 
  • Efficient fully implicit time integration methods for modeling cardiac dynamics. 
  • Elastic properties of normal and hypertrophied cardiac muscle. 
  • Electrical pacing counteracts intrinsic shortening of action potential duration of neonatal rat ventricular cells in culture. 
  • Elevated blood pressure and enhanced myocardial contractility in mice with severe IGF-1 deficiency. 
  • Emerging Therapies for Congestive Heart Failure. 
  • Encircling endocardial ventriculotomy for refractory ischemic ventricular tachycardia. III. Effects on regional left ventricular function. 
  • Enhanced calcium cycling and contractile function in transgenic hearts expressing constitutively active G alpha o* protein. 
  • Enhanced cardiac function in transgenic mice expressing a Ca(2+)-stimulated adenylyl cyclase. 
  • Enhanced contractility and decreased beta-adrenergic receptor kinase-1 in mice lacking endogenous norepinephrine and epinephrine. 
  • Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor. 
  • Enhanced myocardial relaxation in vivo in transgenic mice overexpressing the beta2-adrenergic receptor is associated with reduced phospholamban protein. 
  • Enhancement of cardiac function by cyclocreatine in models of cardiopulmonary bypass. 
  • Enhancement of the force-frequency effect on myocardial contractility by adrenergic stimulation in conscious dogs. 
  • Erythropoietin receptor expression in adult rat cardiomyocytes is associated with an acute cardioprotective effect for recombinant erythropoietin during ischemia-reperfusion injury. 
  • Evaluation of beta-adrenergic influences on cardiovascular and metabolic adjustments to physical and psychological stress. 
  • Evaluation of indices of left ventricular contractility and relaxation in evolving canine experimental heart failure. 
  • Evaluation of left ventricular mechanical dyssynchrony as determined by phase analysis of ECG-gated SPECT myocardial perfusion imaging in patients with left ventricular dysfunction and conduction disturbances. 
  • Evaluation of the left ventricle by two-dimensional echocardiography. 
  • Ex vivo characterization of human anti-porcine hyperacute cardiac rejection. 
  • Extracellular discontinuities in cardiac muscle: evidence for capillary effects on the action potential foot. 
  • FGF23/FGFR4-mediated left ventricular hypertrophy is reversible. 
  • Fiber-optic stethoscope: a cardiac monitoring and gating system for magnetic resonance microscopy. 
  • Field stimulation of cardiac fibers with random spatial structure. 
  • Field stimulation of isolated chick heart cells: comparison of experimental and theoretical activation thresholds. 
  • Force-frequency effect is a powerful determinant of myocardial contractility in the mouse. 
  • Force-frequency relations in the failing rabbit heart and responses to adrenergic stimulation. 
  • Functional abnormalities in isolated left bundle branch block. The effect of interventricular asynchrony. 
  • Functional analysis of myocardial performance in murine hearts overexpressing the human beta 2-adrenergic receptor. 
  • Functional improvement of jeopardized myocardium following intracoronary streptokinase infusion in acute myocardial infarction. 
  • G protein-coupled receptors and receptor kinases: from molecular biology to potential therapeutic applications. 
  • GRK2-mediated inhibition of adrenergic and dopaminergic signaling in right ventricular hypertrophy: therapeutic implications in pulmonary hypertension. 
  • Gadolinium cardiovascular magnetic resonance predicts reversible myocardial dysfunction and remodeling in patients with heart failure undergoing beta-blocker therapy. 
  • Gene and cell-based therapies for heart disease. 
  • Gi-biased β2AR signaling links GRK2 upregulation to heart failure. 
  • Global Longitudinal Strain and Immune Status in Patients Living With Human Immunodeficiency Virus. 
  • Glutamine preserves cardiomyocyte viability and enhances recovery of contractile function after ischemia-reperfusion injury. 
  • HEART DISEASE. Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy. 
  • Hand-held echocardiographic examination of patients with symptoms of acute coronary syndromes in the emergency department: the 30-day outcome associated with normal left ventricular wall motion. 
  • Heart reduction surgery: an analysis of the impact on cardiac function. 
  • Heart regeneration in zebrafish. 
  • Heart size-independent analysis of myocardial function in murine pressure overload hypertrophy. 
  • Hemodynamic and inotropic effects of milrinone after heart transplantation in the setting of recipient pulmonary hypertension. 
  • Hemodynamic and inotropic effects of nitric oxide in pulmonary hypertension. 
  • Hemodynamic changes during dialysis. 
  • Hemodynamic changes during hemodialysis: role of dialyzate. 
  • Hemodynamic consequences of right ventricular isolation: the contribution of the right ventricular free wall to cardiac performance. 
  • Hemodynamic correlates for timing intervals, ejection rate and filling rate derived from the radionuclide angiographic volume curve. 
  • High-Frame-Rate Deformation Imaging in Two Dimensions Using Continuous Speckle-Feature Tracking. 
  • Histologic and biochemical correlates of left ventricular chamber dynamics in man. 
  • Hypertrophy, fibrosis and diastolic dysfunction in early canine experimental hypertension. 
  • Hypotension during dobutamine stress echocardiography: is it related to dynamic intraventricular obstruction? 
  • Hypoxia reprograms calcium signaling and regulates myoglobin expression. 
  • Imbalance between xanthine oxidase and nitric oxide synthase signaling pathways underlies mechanoenergetic uncoupling in the failing heart. 
  • Impaired left ventricular global longitudinal strain in patients with heart failure with preserved ejection fraction: insights from the RELAX trial. 
  • Impaired resting myocardial annular velocities are independently associated with mental stress-induced ischemia in coronary heart disease. 
  • Improved perfusion and contractile reserve after transmyocardial laser revascularization in a model of hibernating myocardium. 
  • Improvement in the function of hibernating myocardium in a patient with heart failure due to coronary artery disease receiving high-dose simvastatin. 
  • In vivo assessment of myocardial stiffness with acoustic radiation force impulse imaging. 
  • In vivo cardiac, acoustic-radiation-force-driven, shear wave velocimetry. 
  • In vivo inhibition of elevated myocardial beta-adrenergic receptor kinase activity in hybrid transgenic mice restores normal beta-adrenergic signaling and function. 
  • Increased myocardial contractility and enhanced exercise function in transgenic mice overexpressing either adenylyl cyclase 5 or 8. 
  • Increased rat cardiac angiotensin converting enzyme activity and mRNA expression in pressure overload left ventricular hypertrophy. Effects on coronary resistance, contractility, and relaxation. 
  • Index of contractile asymmetry improves patient selection for CRT: a proof-of-concept study. 
  • Influences of ultrasonic machine settings, transducer frequency and placement of region of interest on the measurement of integrated backscatter and cyclic variation. 
  • Inhibition of sarco(endo)plasmic reticulum Ca2+-ATPase differentially regulates contractile function in cardiac myocytes from normotensive and spontaneously hypertensive rats: role of Ca2+ regulatory proteins. 
  • Inhibition of spontaneous beta 2-adrenergic activation rescues beta 1-adrenergic contractile response in cardiomyocytes overexpressing beta 2-adrenoceptor. 
  • Insulin-like growth factor-1 but not growth hormone augments mammalian myocardial contractility by sensitizing the myofilament to Ca2+ through a wortmannin-sensitive pathway: studies in rat and ferret isolated muscles. 
  • Intracardiac transplantation of a mixed population of bone marrow cells improves both regional systolic contractility and diastolic relaxation. 
  • Intracoronary adenovirus-mediated delivery and overexpression of the beta(2)-adrenergic receptor in the heart : prospects for molecular ventricular assistance. 
  • Intramyocardial stem cell injection in patients with ischemic cardiomyopathy: functional recovery and reverse remodeling. 
  • Intraoperative assessment of left ventricular heterogeneity. 
  • Intravenous allopurinol decreases myocardial oxygen consumption and increases mechanical efficiency in dogs with pacing-induced heart failure. 
  • Isoflurane, but not halothane, induces protection of human myocardium via adenosine A1 receptors and adenosine triphosphate-sensitive potassium channels. 
  • LV twisting and untwisting in HCM: ejection begets filling. Diastolic functional aspects of HCM. 
  • Left Ventricular Global Longitudinal Strain Can Reliably Be Measured from a Single Apical Four-Chamber View in Patients with Heart Failure. 
  • Left atrial passive emptying function during dobutamine stress MR imaging is a predictor of cardiac events in patients with suspected myocardial ischemia. 
  • Left bundle branch block: angiographic segmental wall motion abnormalities. 
  • Left bundle-branch block is associated with asimilar dyssynchronous phenotype in heart failure patients with normal and reduced ejection fractions. 
  • Left ventricular global longitudinal strain in patients with heart failure with preserved ejection fraction: outcomes following an acute heart failure hospitalization. 
  • Left ventricular mechanical dyssynchrony by cardiac magnetic resonance is greater in patients with strict vs nonstrict electrocardiogram criteria for left bundle-branch block. 
  • Left ventricular remodelling and disparate changes in contractility and relaxation during the development of and recovery from experimental heart failure. 
  • Left ventricular shape, afterload and survival in idiopathic dilated cardiomyopathy. 
  • Left ventricular wall motion analysis using real-time three-dimensional ultrasound. 
  • Letter: Left circumflex coronary artery in SCS. 
  • Limited value of interlaced ECG-gated radiography in the presence of a normal chest radiograph. 
  • Linearity of the Frank-Starling relationship in the intact heart: the concept of preload recruitable stroke work. 
  • Liver transplantation from controlled non-heart-beating donors. 
  • Local contractile and growth modulators in the myocardium. 
  • Localization of the site of ventricular premature complexes by radionuclide angiographic phase imaging. 
  • Long-term captopril treatment improves diastolic filling more than systolic performance in rats with large myocardial infarction. 
  • Long-term contractile activity and thyroid hormone supplementation produce engineered rat myocardium with adult-like structure and function. 
  • Loop diuretics in acute decompensated heart failure: necessary? Evil? A necessary evil? 
  • Low-dose dobutamine tissue-tagged magnetic resonance imaging with 3-dimensional strain analysis allows assessment of myocardial viability in patients with ischemic cardiomyopathy. 
  • MAPK-activated protein kinase-2 in cardiac hypertrophy and cyclooxygenase-2 regulation in heart. 
  • MR imaging of myocardial perfusion and viability. 
  • Magnesium deficiency prolongs myocardial stunning in an open-chest swine model. 
  • Magnetic resonance imaging-based multiparametric systolic strain analysis and regional contractile heterogeneity in patients with dilated cardiomyopathy. 
  • Magnetic resonance microscopy of the rat thorax and abdomen. 
  • Marked enhancement in myocardial function resulting from overexpression of a human beta-adrenergic receptor gene. 
  • Mdm2 regulates cardiac contractility by inhibiting GRK2-mediated desensitization of β-adrenergic receptor signaling. 
  • Mechanical correlates of the third heart sound. 
  • Mechanical determinants of myocardial oxygen consumption in conscious dogs. 
  • Mechanism of beta-adrenergic receptor desensitization in cardiac hypertrophy is increased beta-adrenergic receptor kinase. 
  • Mechanoelectrical excitation by fluid jets in monolayers of cultured cardiac myocytes. 
  • Mechanotransduction mechanisms for intraventricular diastolic vortex forces and myocardial deformations: part 1. 
  • Metabolic deterioration during global ischemia as a function of time in the intact normal dog heart. 
  • Metallothionein abrogates GTP cyclohydrolase I inhibition-induced cardiac contractile and morphological defects: role of mitochondrial biogenesis. 
  • Metallothionein alleviates glutathione depletion-induced oxidative cardiomyopathy in murine hearts. 
  • MicroRNA-mediated in vitro and in vivo direct reprogramming of cardiac fibroblasts to cardiomyocytes. 
  • Mitochondrial dysfunction in human immunodeficiency virus-1 transgenic mouse cardiac myocytes. 
  • Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene. 
  • Modulation of in vivo cardiac function by myocyte-specific nitric oxide synthase-3. 
  • Multiparametric Early Detection and Prediction of Cardiotoxicity Using Myocardial Strain, T1 and T2 Mapping, and Biochemical Markers: A Longitudinal Cardiac Resonance Imaging Study During 2 Years of Follow-Up. 
  • Myocardial Lipin 1 knockout in mice approximates cardiac effects of human LPIN1 mutations. 
  • Myocardial Strain Evaluation with Cardiovascular MRI: Physics, Principles, and Clinical Applications. 
  • Myocardial adenosine triphosphate levels during early sepsis. 
  • Myocardial blood flow and oxygen consumption in the empty-beating, fibrillating, and potassium-arrested hypertrophied canine heart. 
  • Myocardial depression by anesthetic agents (halothane, enflurane and nitrous oxide): quantitation based on end-systolic pressure-dimension relations. 
  • Myocardial function in hearts with transgenic overexpression of the G protein-coupled receptor kinase 5. 
  • Myocardial overexpression of GRK3 in transgenic mice: evidence for in vivo selectivity of GRKs. 
  • Myocardial overexpression of adrenergic receptors and receptor kinases. 
  • Myocardial performance after graft preservation and subsequent cardiac transplantation from brain-dead donors. 
  • Myocardial relaxation and passive diastolic properties in man. 
  • Myocardial salvage after failed coronary angioplasty. 
  • Myocardial thinning in patients with coronary artery disease--reply. 
  • Myocardial viability mapping by magnetic resonance-based multiparametric systolic strain analysis. 
  • NO and superoxide: opposite ends of the seesaw in cardiac contractility. 
  • Nitric oxide improves transpulmonary vascular mechanics but does not change intrinsic right ventricular contractility in an acute respiratory distress syndrome model with permissive hypercapnia. 
  • Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms. 
  • Nitric oxide regulation of myocardial contractility and calcium cycling: independent impact of neuronal and endothelial nitric oxide synthases. 
  • Nitric oxide synthase inhibitors decrease coronary sinus-free radical concentration and ameliorate myocardial stunning in an ischemia-reperfusion model. 
  • Nitric oxide synthase-2 induction optimizes cardiac mitochondrial biogenesis after endotoxemia. 
  • Non-uniform dispersion of the source-sink relationship alters wavefront curvature. 
  • Noncorticosteroid immunosuppression limits myocardial damage and contractile dysfunction in eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome). 
  • Noninvasive assessment of hemodynamics: an emphasis on bioimpedance cardiography. 
  • Noninvasive cineangiography by magnetic resonance global coherent free precession. 
  • Noninvasive detection of periinduction ischemic ventricular dysfunction by cardiokymography in humans: preliminary experience. 
  • Nonuniformity of fetal umbilical systolic/diastolic ratios as determined with duplex Doppler sonography. 
  • Novel acoustic radiation force impulse imaging methods for visualization of rapidly moving tissue. 
  • Novel methodology for echocardiographic quantification of cardiac shape. 
  • Nutritional modulation of heart failure in mitochondrial pyruvate carrier-deficient mice. 
  • Omecamtiv Mecarbil in Chronic Heart Failure With Reduced Ejection Fraction: Rationale and Design of GALACTIC-HF. 
  • Omecamtiv Mecarbil: Decisional Dilemmas and Regulatory Science - Opportunities for Improvement? 
  • On mechanisms of improved ejection fraction by early reperfusion in acute myocardial infarction: myocardial salvage or infarct stiffening? 
  • Origin of body surface QRS and T wave potentials from epicardial potential distributions in the intact chimpanzee. 
  • Origin of epicardial ST-T wave potentials in the intact dog. 
  • Orthogonal properties of the redox siblings nitroxyl and nitric oxide in the cardiovascular system: a novel redox paradigm. 
  • Ouabain effects on intracellular potassium activity and contractile force in cat papillary muscle. 
  • Overexpression of the cardiac beta(2)-adrenergic receptor and expression of a beta-adrenergic receptor kinase-1 (betaARK1) inhibitor both increase myocardial contractility but have differential effects on susceptibility to ischemic injury. 
  • Overexpression of the rat sarcoplasmic reticulum Ca2+ ATPase gene in the heart of transgenic mice accelerates calcium transients and cardiac relaxation. 
  • Oxygen sufficiency in working rabbit papillary muscle at 35 degrees C. 
  • Paracrine mechanisms in adult stem cell signaling and therapy. 
  • Perturbed length-dependent activation in human hypertrophic cardiomyopathy with missense sarcomeric gene mutations. 
  • Pharmacological and toxicological evaluation of 2-fluoro-3-(2(S)-azetidinylmethoxy)pyridine (2-F-A-85380), a ligand for imaging cerebral nicotinic acetylcholine receptors with positron emission tomography. 
  • Phenylephrine induces delayed cardioprotection against necrosis without amelioration of stunning. 
  • Physiologic effects of extracellular superoxide dismutase transgene overexpression on myocardial function after ischemia and reperfusion injury. 
  • Physiological determinants of hyperreactivity to stress in borderline hypertension. 
  • Physiological induction of a beta-adrenergic receptor kinase inhibitor transgene preserves ss-adrenergic responsiveness in pressure-overload cardiac hypertrophy. 
  • Potential distribution in three-dimensional periodic myocardium--Part I: Solution with two-scale asymptotic analysis. 
  • Potential distribution in three-dimensional periodic myocardium--Part II: Application to extracellular stimulation. 
  • Prediction of myocardial perfusion abnormalities by quantitative regional function using a radionuclide angiography database: a comparison with wall motion analysis. 
  • Predictors of inotrope use during separation from cardiopulmonary bypass. 
  • Prevalence of regional myocardial thinning and relationship with myocardial scarring in patients with coronary artery disease. 
  • Principal strain orientation in the normal human left ventricle. 
  • Prognostic implications of ventricular arrhythmias during 24 hour ambulatory monitoring in patients undergoing cardiac catheterization for coronary artery disease. 
  • Prospective, randomized trial comparing blood and oxygenated crystalloid cardioplegia in reoperative coronary artery bypass grafting. 
  • Prosthetic mitral valve replacement: late complications after native valve preservation. 
  • Pulmonary vascular impedance analysis of adaptation to chronically elevated blood flow in the awake dog. 
  • Pulsus alternans induced by inferior vena caval occlusion in man. 
  • Pulsus alternans: a visual clue to a grave disorder! 
  • Quantification of the contractile response to injury: assessment of the work-length relationship in the intact heart. 
  • Quantifying Myocardial Contractility Changes Using Ultrasound-Based Shear Wave Elastography. 
  • Quantitative regional wall motion analysis with early contrast ventriculography for the assessment of myocardium at risk in acute myocardial infarction. 
  • Real-time three-dimensional echocardiography to construct clinically ready, load-independent indices of myocardial contractile performance. 
  • Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice. 
  • Recovery of systolic and diastolic left ventricular function after a 60-second coronary arterial occlusion during percutaneous transluminal coronary angioplasty for angina pectoris. 
  • Redistribution of canine left ventricular myocardial blood flow in unloaded systole. 
  • Reduced left ventricular filling following blood volume extraction does not result in compensatory augmentation of cardiac mechanics. 
  • Regional geometry and function during myocardial ischemia and recovery. 
  • Relation between myocardial perfusion and left ventricular function following acute coronary occlusion: disproportionate effects of anterior vs. inferior ischemia. 
  • Relation between radionuclide angiographic regional ejection fraction and left ventricular regional ischemia in awake dogs. 
  • Relation between reversal of diastolic creep and recovery of systolic function after ischemic myocardial injury in conscious dogs. 
  • Relationship between ischemic contracture and mitochondrial function. 
  • Relationship between repolarization heterogeneity and abnormal myocardial mechanics. 
  • Relationship of MRI delayed contrast enhancement to irreversible injury, infarct age, and contractile function. 
  • Relationship of contractile function to transmural extent of infarction in patients with chronic coronary artery disease. 
  • Relationships among ventricular arrhythmias, coronary artery disease, and angiographic and electrocardiographic indicators of myocardial fibrosis. 
  • Remodeled cardiac calcium channels. 
  • Reproducibility of Left Ventricular Dimension Versus Area Versus Volume Measurements in Pediatric Patients With Dilated Cardiomyopathy. 
  • Response of hypertrophied myocardium to ischemia: correlation with biochemical and physiological parameters. 
  • Restoration of beta-adrenergic receptor signaling and contractile function in heart failure by disruption of the betaARK1/phosphoinositide 3-kinase complex. 
  • Right and left ventricular performance during and after abdominal aortic aneurysm repair. 
  • Right ventricular dysfunction in systemic sclerosis-associated pulmonary arterial hypertension. 
  • Right ventricular morphology and systolic function in left ventricular noncompaction cardiomyopathy. 
  • Role of soluble epoxide hydrolase in postischemic recovery of heart contractile function. 
  • S-Nitrosylation of Sarcomeric Proteins Depresses Myofilament Ca2+)Sensitivity in Intact Cardiomyocytes. 
  • ST-Segment recovery adds to the assessment of TIMI 2 and 3 flow in predicting infarct wall motion after thrombolytic therapy. 
  • Safety and efficacy of inferior vena caval occlusion to rapidly alter ventricular loading conditions in idiopathic dilated cardiomyopathy. 
  • Selective phosphorylation of PKA targets after β-adrenergic receptor stimulation impairs myofilament function in Mybpc3-targeted HCM mouse model. 
  • Serial echocardiographic assessment of left ventricular geometry and function after large myocardial infarction in the rat. 
  • Serial evaluation of right ventricular dysfunction associated with acute inferior myocardial infarction. 
  • Signal transduction in cardiac hypertrophy--dissecting compensatory versus pathological pathways utilizing a transgenic approach. 
  • Simple regional strain pattern analysis to predict response to cardiac resynchronization therapy: rationale, initial results, and advantages. 
  • Simulated microgravity produces attenuated baroreflex-mediated pressor, chronotropic, and inotropic responses in mice. 
  • Simulation of propagation along a cylindrical bundle of cardiac tissue--I: Mathematical formulation. 
  • Simulation of propagation along a cylindrical bundle of cardiac tissue--II: Results of simulation. 
  • Simultaneous pancreas-kidney (SPK) transplantation from controlled non-heart-beating donors (NHBDs). 
  • Size and ionic currents of unexcitable cells coupled to cardiomyocytes distinctly modulate cardiac action potential shape and pacemaking activity in micropatterned cell pairs. 
  • Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction. 
  • Spectral-domain phase microscopy. 
  • Strength-interval curves in canine myocardium at very short cycle lengths. 
  • Stress-activated MAP kinases in cardiac remodeling and heart failure; new insights from transgenic studies. 
  • Structural remodeling of cardiac myocytes in patients with ischemic cardiomyopathy. 
  • Structural remodelling in heart failure: gelatinase induction. 
  • Systolic time interval characteristics in children with Duchenne's progressive muscular dystrophy. 
  • Targeted beta-adrenergic receptor kinase (betaARK1) inhibition by gene transfer in failing human hearts. 
  • Targeted overexpression of phospholamban to mouse atrium depresses Ca2+ transport and contractility. 
  • Technology insight: assessment of myocardial viability by delayed-enhancement magnetic resonance imaging. 
  • The Association of a classical left bundle Branch Block Contraction Pattern by vendor-independent strain echocardiography and outcome after cardiac resynchronization therapy. 
  • The Prevalence, Correlates, and Impact on Cardiac Mortality of Right Ventricular Dysfunction in Nonischemic Cardiomyopathy. 
  • The combined effects of brain death and cardiac graft preservation on cardiopulmonary hemodynamics and function before and after subsequent heart transplantation. 
  • The comparative effects of drive and test stimulus intensity on myocardial excitability and vulnerability. 
  • The effect of PEEP on left ventricular diastolic dimensions and systolic performance following myocardial revascularization. 
  • The effects of airway pressure on cardiac function in intact dogs and man. 
  • The effects of coronary revascularization on left ventricular function in ischemic heart disease. 
  • The effects of dopamine on myocardial functional recovery after reversible ischemic injury. 
  • The effects of ventricular pacing on left ventricular geometry, function, myocardial oxygen consumption, and efficiency of contraction in conscious dogs. 
  • The end-systolic pressure-volume relationship in conscious dogs. 
  • The impact of adjacent isotropic fluids on electrograms from anisotropic cardiac muscle. A modeling study. 
  • The incidence and functional consequences of RT-associated cardiac perfusion defects. 
  • The influence of time on the response to dopamine after coronary artery bypass grafting: assessment of left ventricular performance and contractility using pressure/dimension analyses. 
  • The mechanism of halothane-induced myocardial depression. Altered diastolic mechanics versus impaired contractility. 
  • The nuclear receptor RORα protects against angiotensin II-induced cardiac hypertrophy and heart failure. 
  • The possible physiologic importance of calcium complexes: an opinion. 
  • The relationship of transmural myocardial blood flow to midwall function. 
  • The restitution portrait: a new method for investigating rate-dependent restitution. 
  • The third beta is not the charm. 
  • The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction. 
  • The use of radionuclide angiography in the diagnosis of coronary artery disease--a logistic regression analysis. 
  • Theophylline produces an adverse effect on myocardial lactate metabolism at a therapeutic serum concentration: an effect blocked by verapamil. 
  • Therapeutic Effect of Targeting Branched-Chain Amino Acid Catabolic Flux in Pressure-Overload Induced Heart Failure. 
  • Tissue plasminogen activator: Toronto (TPAT) placebo-controlled randomized trial in acute myocardial infarction. 
  • Tissue-engineered cardiac patch for advanced functional maturation of human ESC-derived cardiomyocytes. 
  • To excite a heart: a bird's view. 
  • To the editor: functional imaging(FI) combines imaging datasets and computational fluid dynamics to simulate cardiac flows. 
  • Towards a better characterization of cirrhosis-associated cardiomyopathy? 
  • Transgenic mice with cardiac overexpression of alpha1B-adrenergic receptors. In vivo alpha1-adrenergic receptor-mediated regulation of beta-adrenergic signaling. 
  • Transgenic overexpression of the Ca2+-binding protein S100A1 in the heart leads to increased in vivo myocardial contractile performance. 
  • Transient alterations of the QRS complex and ST segment during percutaneous transluminal balloon angioplasty of the left anterior descending coronary artery. 
  • Transmural extent of acute myocardial infarction predicts long-term improvement in contractile function. 
  • Troglitazone stimulates beta-arrestin-dependent cardiomyocyte contractility via the angiotensin II type 1A receptor. 
  • Type V Collagen in Scar Tissue Regulates the Size of Scar after Heart Injury. 
  • Ultrasound Visualization and Recording of Transient Myocardial Vibrations. 
  • Use of an isolated heart model to test the utilization of substrates for inclusion in cardioplegic solutions. 
  • Use of cardiac magnetic resonance to assess viability. 
  • Using a gene-switch transgenic approach to dissect distinct roles of MAP kinases in heart failure. 
  • Variable responses of mitral valve motion and flow in systemic hypertension and in idiopathic dilated cardiomyopathy. 
  • Variant R94C in TNNT2-Encoded Troponin T Predisposes to Pediatric Restrictive Cardiomyopathy and Sudden Death Through Impaired Thin Filament Relaxation Resulting in Myocardial Diastolic Dysfunction. 
  • Vasopressin: a new target for the treatment of heart failure. 
  • Ventricular and myocardial efficiencies during acute aortic regurgitation in conscious dogs. 
  • Ventricular cryosurgery: short-term effects on intramural electrophysiology. 
  • Ventricular expression of a MLC-2v-ras fusion gene induces cardiac hypertrophy and selective diastolic dysfunction in transgenic mice. 
  • Ventricular intramural and epicardial potential distributions during ventricular activation and repolarization in the intact dog. 
  • [Cardiac contractility modulation in heart failure with reduced ejection fraction treatment]. 
  • beta(3)-adrenoceptor deficiency blocks nitric oxide-dependent inhibition of myocardial contractility. 
  • cGMP-independent inotropic effects of nitric oxide and peroxynitrite donors: potential role for nitrosylation. 
  • cTnT1, a cardiac troponin T isoform, decreases myofilament tension and affects the left ventricular pressure waveform. 
  • p38 Mitogen-activated protein kinase mediates a negative inotropic effect in cardiac myocytes. 
  • p38-MAPK induced dephosphorylation of alpha-tropomyosin is associated with depression of myocardial sarcomeric tension and ATPase activity. 
  • β-Arrestin mediates the Frank-Starling mechanism of cardiac contractility. 
  • β-Arrestin-biased AT1R stimulation promotes cell survival during acute cardiac injury. 
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  Keywords of People

  • Badea, Cristian Tudorel, Professor in Radiology, Biomedical Engineering
  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Johnson, G. Allan, Charles E. Putman University Distinguished Professor of Radiology, Biomedical Engineering
  • Milano, Carmelo Alessio, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Surgery, Cardiovascular and Thoracic Surgery
  • O'Connor, Christopher Michael, Adjunct Professor in the Department of Medicine, Medicine, Clinical Pharmacology
  • Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology