Myopia

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  Subject Areas on Research

  • A cluster randomised controlled trial evaluating an incentive-based outdoor physical activity programme to increase outdoor time and prevent myopia in children. 
  • A cohort study of incident myopia in Singaporean children. 
  • A comparison of the rate of refractive growth in pediatric aphakic and pseudophakic eyes. 
  • A genome-wide association study for myopia and refractive error identifies a susceptibility locus at 15q25. 
  • A genome-wide association study identifies a susceptibility locus for refractive errors and myopia at 15q14. 
  • A new community-based outdoor intervention to increase physical activity in Singapore children: findings from focus groups. 
  • A second locus for familial high myopia maps to chromosome 12q. 
  • Academic achievement, close up work parameters, and myopia in Singapore military conscripts. 
  • Acute corneal endothelial changes after laser in situ keratomileusis. 
  • Acute loss of fusional convergence following head trauma. 
  • Age of onset of myopia predicts risk of high myopia in later childhood in myopic Singapore children. 
  • An evidence-based update on myopia and interventions to retard its progression. 
  • An international collaborative family-based whole genome quantitative trait linkage scan for myopic refractive error. 
  • Anisometropia at Age 5 Years After Unilateral Intraocular Lens Implantation During Infancy in the Infant Aphakia Treatment Study. 
  • Apoptosis in human retinal degenerations. 
  • Are myopic eyes less likely to have diabetic retinopathy? 
  • Assessment of central corneal thickness in normal, keratoconus, and post-laser in situ keratomileusis eyes using Scheimpflug imaging, spectral domain optical coherence tomography, and ultrasound pachymetry. 
  • Association mapping of the high-grade myopia MYP3 locus reveals novel candidates UHRF1BP1L, PTPRR, and PPFIA2. 
  • Association of intraocular pressure and myopia in children. 
  • BMI and retinal vascular caliber in children. 
  • Biofeedback techniques in the treatment of visual and ophthalmologic disorders: a review of the literature. 
  • Birth order and myopia. 
  • COL1A1 and COL2A1 genes and myopia susceptibility: evidence of association and suggestive linkage to the COL2A1 locus. 
  • Caveats to obtaining retinal topography with optical coherence tomography. 
  • Change in peripheral refraction over time in Singapore Chinese children. 
  • Changes in refraction over 10 years in an adult population: the Beaver Dam Eye study. 
  • Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia: The CREAM Consortium. 
  • Choroidal neovascularization in pathological myopia. 
  • Comment on 'A PAX6 gene polymorphism is associated with genetic predisposition to extreme myopia'. 
  • Common MFRP sequence variants are not associated with moderate to high hyperopia, isolated microphthalmia, and high myopia. 
  • Comparative analyses of seven algorithms for copy number variant identification from single nucleotide polymorphism arrays. 
  • Comparison of corneal deposits after LASIK and PRK in eyes with granular corneal dystrophy type II. 
  • Comparison of measurements of time outdoors and light levels as risk factors for myopia in young Singapore children. 
  • Consultation section: cataract surgical problem. 
  • Contrast sensitivity in extended wear of the Boston IV lens. 
  • Correction of refractive errors in rhesus macaques (Macaca mulatta) involved in visual research. 
  • Correlation of structural and electrophysiological changes in the retina of young high myopes. 
  • Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases. 
  • Development of myopia in infants with birth weights less than 1251 grams. The Cryotherapy for Retinopathy of Prematurity Cooperative Group. 
  • Diet and risk of myopia in three-year-old Singapore children: the GUSTO cohort. 
  • Dietary factors, myopia, and axial dimensions in children. 
  • Differential associations of myopia with major age-related eye diseases: the Singapore Indian Eye Study. 
  • Dissecting the genetics of human high myopia: a molecular biologic approach. 
  • Distribution of refractive error in healthy infants. 
  • Drug-induced transient myopia and angle-closure glaucoma associated with supraciliary choroidal effusion. 
  • Education, socioeconomic status, and ocular dimensions in Chinese adults: the Tanjong Pagar Survey. 
  • Elevated blood pressure is associated with rarefaction of the retinal vasculature in children. 
  • Epithelial breakthrough during IntraLase flap creation for laser in situ keratomileusis. 
  • Evaluation of Lipin 2 as a candidate gene for autosomal dominant 1 high-grade myopia. 
  • Evaluation of the relationship between ablation diameter, pupil size, and visual function with vision-specific quality-of-life measures after laser in situ keratomileusis. 
  • Evidence that a locus for familial high myopia maps to chromosome 18p. 
  • Exacerbation of Avellino corneal dystrophy after laser in situ keratomileusis. 
  • Exclusion of lumican and fibromodulin as candidate genes in MYP3 linked high grade myopia. 
  • Exome Sequence Analysis of 14 Families With High Myopia. 
  • Factors affecting signal strength in spectral-domain optical coherence tomography. 
  • Familial correlation of retinal vascular caliber in Singapore Chinese. 
  • Family history, near work, outdoor activity, and myopia in Singapore Chinese preschool children. 
  • Further refinement of the MYP2 locus for autosomal dominant high myopia by linkage disequilibrium analysis. 
  • Genetic association of insulin-like growth factor-1 polymorphisms with high-grade myopia in an international family cohort. 
  • Genetic association of refractive error and axial length with 15q14 but not 15q25 in the Blue Mountains Eye Study cohort. 
  • Genetic contributions to myopic refractive error: Insights from human studies and supporting evidence from animal models. 
  • Genetic linkage study of high-grade myopia in a Hutterite population from South Dakota. 
  • Genetic variants on chromosome 1q41 influence ocular axial length and high myopia. 
  • Genetically low vitamin D concentrations and myopic refractive error: a Mendelian randomization study. 
  • Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error. 
  • Genome-wide association study identifies ZFHX1B as a susceptibility locus for severe myopia. 
  • Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. 
  • Genome-wide meta-analysis of myopia and hyperopia provides evidence for replication of 11 loci. 
  • Glaucoma and myopia: are they related? 
  • Global Prevalence of Myopia and High Myopia and Temporal Trends from 2000 through 2050. 
  • Hemi-retinal vein occlusion following LASIK. 
  • Hepatocyte growth factor and myopia: genetic association analyses in a Caucasian population. 
  • Hepatocyte growth factor and retinal arteriolar diameter in Singapore Chinese. 
  • Hyperopic refractive error and shorter axial length are associated with age-related macular degeneration: the Singapore Malay Eye Study. 
  • IMI - Myopia Genetics Report. 
  • Identification of a novel locus on 2q for autosomal dominant high-grade myopia. 
  • Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia. 
  • Influence of myopic macular degeneration severity on treatment outcomes with intravitreal aflibercept in the MYRROR study. 
  • Intraocular pressure and its relationship to ocular and systemic factors in a healthy Chinese rural population: the Handan Eye Study. 
  • Intravitreal delivery of a novel AAV vector targets ON bipolar cells and restores visual function in a mouse model of complete congenital stationary night blindness. 
  • Is it possible to slow the progression of myopia? 
  • Is there a link between passive smoke exposure and early-onset myopia in preschool Asian children? 
  • Issues and challenges for myopia research. 
  • Joint Effects of Intraocular Pressure and Myopia on Risk of Primary Open-Angle Glaucoma: The Singapore Epidemiology of Eye Diseases Study. 
  • Lack of awareness of common eye conditions in the community. 
  • Large scale international replication and meta-analysis study confirms association of the 15q14 locus with myopia. The CREAM consortium. 
  • Large-Scale microRNA Expression Profiling Identifies Putative Retinal miRNA-mRNA Signaling Pathways Underlying Form-Deprivation Myopia in Mice. 
  • Lens opacity and refractive influences on the measurement of retinal vascular fractal dimension. 
  • Lumican and muscarinic acetylcholine receptor 1 gene polymorphisms associated with high myopia. 
  • Molecular genetics of human myopia: an update. 
  • Mutations in SCO2 are associated with autosomal-dominant high-grade myopia. 
  • Myocilin polymorphisms and high myopia in subjects of European origin. 
  • Myopia - A 21st Century Public Health Issue. 
  • Myopia and age-related cataract: a systematic review and meta-analysis. 
  • Myopia and cognitive dysfunction: the singapore malay eye study. 
  • Myopia genetics: a review of current research and emerging trends. 
  • Myopia in young adults is inversely related to an objective marker of ocular sun exposure: the Western Australian Raine cohort study. 
  • Myopia predicts better outcome in persistent hyperplastic primary vitreous. 
  • Myopia, axial length, and OCT characteristics of the macula in Singaporean children. 
  • Myopia, axial length, and age-related cataract: the Singapore Malay eye study. 
  • Myopia-The Silent Epidemic That Should Not Be Ignored. 
  • Myopia-related optic disc and retinal changes in adolescent children from singapore. 
  • Myopic Shift 5 Years after Intraocular Lens Implantation in the Infant Aphakia Treatment Study. 
  • New equivalent keratometry reading calculation with a rotating Scheimpflug camera for intraocular lens power calculation after myopic corneal surgery. 
  • New locus for autosomal dominant high myopia maps to the long arm of chromosome 17. 
  • Ocular Biometrics of Myopic Eyes With Narrow Angles. 
  • Ocular and histologic findings in a series of children with infantile pompe disease treated with enzyme replacement therapy. 
  • Ocular component growth curves among Singaporean children with different refractive error status. 
  • Ophthalmologic findings in Cornelia de Lange syndrome: a genotype-phenotype correlation study. 
  • Optical coherence tomography accurately measures corneal power change from laser refractive surgery. 
  • Outcomes of photorefractive keratectomy enhancement after LASIK. 
  • Outdoor activity and myopia in Singapore teenage children. 
  • Pathologic changes in highly myopic eyes of young males in Singapore. 
  • Pediatric cataract, myopic astigmatism, familial exudative vitreoretinopathy and primary open-angle glaucoma co-segregating in a family. 
  • Peripapillary choroidal thickness in young Asians with high myopia. 
  • Peripheral refraction and refractive error in singapore chinese children. 
  • Persistent anterior chamber gas bubbles during IntraLASIK. 
  • Posterior Eye Shape Measurement With Retinal OCT Compared to MRI. 
  • Posterior corneal elevation after LASIK with three flap techniques as measured by Pentacam. 
  • Prevalence and characteristics of myopic retinopathy in a rural Chinese adult population: the Handan Eye Study. 
  • Prevalence and risk factors for refractive errors and ocular biometry parameters in an elderly Asian population: the Singapore Longitudinal Aging Study (SLAS). 
  • Prevalence, Risk Factors, and Impact of Myopic Macular Degeneration on Visual Impairment and Functioning Among Adults in Singapore. 
  • Progression of myopia and high myopia in the Early Treatment for Retinopathy of Prematurity study: findings at 4 to 6 years of age. 
  • Progression of myopia in youth: age of cessation. 
  • Pseudomyopia in exodeviations. 
  • Psychophysical measurement of marmoset acuity and myopia. 
  • Quality of DNA extracted from mouthwashes. 
  • Racial variations in the prevalence of refractive errors in the United States: the multi-ethnic study of atherosclerosis. 
  • Re: Evidence for an "epidemic" of myopia. 
  • Reduction of IOP after PRK. 
  • Refinement of the X-linked nonsyndromic high-grade myopia locus MYP1 on Xq28 and exclusion of 13 known positional candidate genes by direct sequencing. 
  • Refractive changes after pediatric intraocular lens implantation. 
  • Refractive changes after pediatric intraocular lens implantation. 
  • Refractive changes after pediatric intraocular lens implantation. 
  • Refractive error, axial dimensions, and primary open-angle glaucoma: the Singapore Malay Eye Study. 
  • Refractive errors, intraocular pressure, and glaucoma in a white population. 
  • Refractive surgery in children: treatment options, outcomes, and controversies. 
  • Relative Contribution of Risk Factors for Early-Onset Myopia in Young Asian Children. 
  • Repeatability of corneal parameters with Pentacam after laser in situ keratomileusis. 
  • Reply. 
  • Response to Mahroo et al. 
  • Responsiveness of the National Eye Institute Refractive Error Quality of Life instrument to surgical correction of refractive error. 
  • Retinal vessel caliber and myopic retinopathy: the blue mountains eye study. 
  • Retinopathy of prematurity: late complications in the baby boomer generation (1946-1964). 
  • Review of key findings from the Singapore Malay Eye Study (SiMES-1). 
  • Sequence variants in the transforming growth beta-induced factor (TGIF) gene are not associated with high myopia. 
  • Spontaneous improvement of myopic macular retinoschisis: case report and review of literature. 
  • Study of a US cohort supports the role of ZNF644 and high-grade myopia susceptibility. 
  • The age-specific prevalence of myopia in Asia: a meta-analysis. 
  • The association of astigmatism and spherical refractive error in a high myopia cohort. 
  • The economic cost of myopia in adults aged over 40 years in Singapore. 
  • The effect of parental history of myopia on eye size of pre-school children: a pilot study. 
  • The effect of procedure room temperature and humidity on LASIK outcomes. 
  • The impact of corrected and uncorrected refractive error on visual functioning: the Singapore Malay Eye Study. 
  • The organophosphate pesticide chlorpyrifos affects form deprivation myopia. 
  • The use of HRT with and without the aid of disc photographs. 
  • Theoretical strategy for choosing piggyback intraocular lens powers in young children. 
  • Treatment of radiation-induced tissue injury by hyperbaric oxygen. 
  • Trio-based exome sequencing arrests de novo mutations in early-onset high myopia. 
  • Ultrasonographic measurement of induced myopia associated with capsular bag distention syndrome. 
  • Unilateral intraocular lens implantation during the first six months of life. 
  • Usefulness of refractive measurement of wavefront autorefraction in patients with difficult retinoscopy. 
  • Variation in prevalence of myopia between generations of migrant indians living in Singapore. 
  • Variations in opsin coding sequences cause x-linked cone dysfunction syndrome with myopia and dichromacy. 
  • Visual acuity improvement following fading and feedback training--I. Comparison of myopic and emmetropic volunteers. 
  • White ring sign for uneventful lenticule separation in small-incision lenticule extraction. 
  • X-linked high myopia associated with cone dysfunction. 
  • [Results after laser epithelial keratectomileusis for myopia]. 
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  Keywords of People

  • Farsiu, Sina, Paul Ruffin Scarborough Associate Professor of Engineering, Electrical and Computer Engineering
  • Fekrat, Sharon, Professor of Ophthalmology, Ophthalmology, Vitreoretinal Diseases & Surgery
  • Li, Yi-Ju, Associate Professor of Biostatistics and Bioinformatics, Duke Molecular Physiology Institute
  • Toth, Cynthia Ann, Joseph A.C. Wadsworth Professor of Ophthalmology, Ophthalmology, Vitreoretinal Diseases & Surgery