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Subject Areas on Research
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A mutation in TNNC1-encoded cardiac troponin C, TNNC1-A31S, predisposes to hypertrophic cardiomyopathy and ventricular fibrillation.
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A new structural state of myosin.
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Abelson kinase (Abl) and RhoGEF2 regulate actin organization during cell constriction in Drosophila.
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Actin and myosin function in acanthamoeba.
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Active cellular materials.
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Antibody inhibitors of nonmuscle myosin function and assembly.
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Apparent elastic modulus and hysteresis of skeletal muscle cells throughout differentiation.
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Association of myosin light chain kinase with lymphocyte membrane-cytoskeleton complex.
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Atypical myosin heavy chain in rat laryngeal muscle.
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Biochemical comparison of fast- and slow-contracting squid muscle.
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Calmodulin in endocrine cells and its multiple roles in hormone action.
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Cell mechanics: dissecting the physical responses of cells to force.
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Characterization of monoclonal antibodies to Acanthamoeba myosin-I that cross-react with both myosin-II and low molecular mass nuclear proteins.
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Characterization of myosin heavy chain by cyanogen bromide peptide maps.
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Cleavage-furrow formation without F-actin in Chlamydomonas
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Contractile proteins in Drosophila development.
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Control of basement membrane remodeling and epithelial branching morphogenesis in embryonic lung by Rho and cytoskeletal tension.
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Coordinate changes in C protein and myosin expression during skeletal muscle hypertrophy.
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Coordinate synthesis of two myosins in wild-type and mutant nematode muscle during larval development.
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Cytoplasmic myosin from Drosophila melanogaster.
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Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle.
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Diatom gliding is the result of an actin-myosin motility system.
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Different dimerization activities of alpha and beta thyroid hormone receptor isoforms.
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Differential gene expression in pubococcygeus muscle from patients with pelvic organ prolapse.
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Dimerized Drosophila myosin VIIa: a processive motor.
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Direct involvement of yeast type I myosins in Cdc42-dependent actin polymerization.
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Direct localization of monoclonal antibody-binding sites on Acanthamoeba myosin-II and inhibition of filament formation by antibodies that bind to specific sites on the myosin-II tail.
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Directionality and processivity of molecular motors.
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Drosophila crinkled, mutations of which disrupt morphogenesis and cause lethality, encodes fly myosin VIIA.
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Drosophila nonmuscle myosin II has multiple essential roles in imaginal disc and egg chamber morphogenesis.
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Dynamic changes in the distribution of cytoplasmic myosin during Drosophila embryogenesis.
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Effect of Mts1 on the structure and activity of nonmuscle myosin II.
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Effect of maturational changes in myosin content and morphometry on airway smooth muscle contraction.
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Effect of microRNA modulation on bioartificial muscle function.
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Effects of taxol and Colcemid on myofibrillogenesis.
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Effects of topical glaucoma drugs on fistulized rabbit conjunctiva.
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Electron microscopy of thin filaments decorated with a Ca2+-regulated myosin.
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Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor.
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Essential light chain of Drosophila nonmuscle myosin II.
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Evidence that myosin does not contribute to force production in chromosome movement.
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Expression of a novel combination of fast and slow troponin T isoforms in rabbit extraocular muscles.
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Expression of dominant negative Rho-binding domain of Rho-kinase in organ cultured human eye anterior segments increases aqueous humor outflow.
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Fluorescence changes on contractile activation in TnC(DANZ) labeled skinned rabbit psoas fibers.
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Fluorine-18-antimyosin monoclonal antibody fragments: preliminary investigations in a canine myocardial infarct model.
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Force fluctuations in three-dimensional suspended fibroblasts.
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Force generation by kinesin and myosin cytoskeletal motor proteins.
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Functions of the myosin ATP and actin binding sites are required for C. elegans thick filament assembly.
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Gene expression in the rectus abdominus muscle of patients with and without pelvic organ prolapse.
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Genetic analysis demonstrates a direct link between rho signaling and nonmuscle myosin function during Drosophila morphogenesis.
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Genetic approaches to molecular motors.
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Genetic contribution to variation in DNA methylation at maternal smoking-sensitive loci in exposed neonates.
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Gleevec, an Abl family inhibitor, produces a profound change in cell shape and migration.
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Glucocorticoids accelerate the ontogenetic transition of cardiac ventricular myosin heavy-chain isoform expression in the rat: promotion by prenatal exposure to a low dose of dexamethasone.
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Hepatitis-C-virus-induced microRNAs dampen interferon-mediated antiviral signaling.
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High-resolution mapping of intracellular fluctuations using carbon nanotubes.
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Human erythrocyte clathrin and clathrin-uncoating protein.
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Human erythrocyte myosin: identification and purification.
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Human nonsyndromic hereditary deafness DFNA17 is due to a mutation in nonmuscle myosin MYH9.
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Human skeletal muscle fibre contractile properties and proteomic profile: adaptations to 3 weeks of unilateral lower limb suspension and active recovery.
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Identification of functional regions on the tail of Acanthamoeba myosin-II using recombinant fusion proteins. I. High resolution epitope mapping and characterization of monoclonal antibody binding sites.
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Identification of the functionally relevant calmodulin binding site in smooth muscle caldesmon.
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Identification of the gene for fly non-muscle myosin heavy chain: Drosophila myosin heavy chains are encoded by a gene family.
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Immunocytochemical localization of two myosins within the same muslce cells in Caenorhabditis elegans.
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Intraoperative floppy iris syndrome: report of a case and histopathologic analysis.
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Involvement of an actomyosin contractile ring in Saccharomyces cerevisiae cytokinesis.
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Kinesin: switch I & II and the motor mechanism.
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Light-Triggered Myosin Activation for Probing Dynamic Cellular Processes
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MRCK-1 Drives Apical Constriction in C. elegans by Linking Developmental Patterning to Force Generation.
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Marked enhancement in myocardial function resulting from overexpression of a human beta-adrenergic receptor gene.
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Modulation of aqueous humor outflow facility by the Rho kinase-specific inhibitor Y-27632.
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Molecular genetic dissection of myosin heavy chain function.
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Monoclonal antibodies demonstrate limited structural homology between myosin isozymes from Acanthamoeba.
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Morphogenesis in Drosophila requires nonmuscle myosin heavy chain function.
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Myocardial expression of a constitutively active alpha 1B-adrenergic receptor in transgenic mice induces cardiac hypertrophy.
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Myosin VIIA defects, which underlie the Usher 1B syndrome in humans, lead to deafness in Drosophila.
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Myosin VIIA, important for human auditory function, is necessary for Drosophila auditory organ development.
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Myosin from human erythrocytes.
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Myosin heavy-chain mutations that disrupt Caenorhabditis elegans thick filament assembly.
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Myosin light chain-2 luciferase transgenic mice reveal distinct regulatory programs for cardiac and skeletal muscle-specific expression of a single contractile protein gene.
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Myosins exist as homodimers of heavy chains: demonstration with specific antibody purified by nematode mutant myosin affinity chromatography.
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Native nonmuscle myosin II stability and light chain binding in Drosophila melanogaster.
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Nonequilibrium dynamics of probe filaments in actin-myosin networks.
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Novel compound heterozygous mutations in MYO7A in a Chinese family with Usher syndrome type 1.
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Ontogenetic transition of cardiac myosin heavy chain isoforms in rat ventricle: effects of fetal exposure to beta-adrenergic agonists or antagonists.
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Orotic acid improves left ventricular recovery four days after heterotopic transplantation.
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Patterns of troponin T expression in mammalian fast, slow and promiscuous muscle fibres.
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Promiscuous expression of myosin in myotonic dystrophy.
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Protein kinase C phosphorylates nonmuscle myosin-II heavy chain from Drosophila but regulation of myosin function by this enzyme is not required for viability in flies.
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Purification and characterization of the mammalian myosin light chain phosphatase holoenzyme. The differential effects of the holoenzyme and its subunits on smooth muscle.
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ROCK1 phosphorylates and activates zipper-interacting protein kinase.
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Rapid local compression in active gels is caused by nonlinear network response.
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Red blood cell and fibroblast membranes in Duchenne and myotonic muscular dystrophy.
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Reentry into the cell cycle of differentiated skeletal myocytes.
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Reverse actin sliding triggers strong myosin binding that moves tropomyosin.
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Reversible unfolding of fibronectin type III and immunoglobulin domains provides the structural basis for stretch and elasticity of titin and fibronectin.
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Role of myosin-II phosphorylation in V12Cdc42-mediated disruption of Drosophila cellularization.
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Sequence divergence of coiled coils--structural rods, myosin filament packing, and the extraordinary conservation of cohesins.
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Simulated actin reorganization mediated by motor proteins.
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Single-headed myosin II acts as a dominant negative mutation in Dictyostelium.
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Sites of interaction between kinase-related protein and smooth muscle myosin.
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Skeletal muscle adaptation to chronic low-frequency motor nerve stimulation.
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Soluble miniagrin enhances contractile function of engineered skeletal muscle.
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Springs and hinges: dynamic coiled coils and discontinuities.
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Stimulation of Acanthamoeba actomyosin ATPase activity by myosin-II polymerization.
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Superresolution microscopy reveals actomyosin dynamics in medioapical arrays.
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Supramolecular and Liquid Crystalline Contributions to the Assembly of Myofibril.
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The actin membrane skeleton in Drosophila development.
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The human extraocular muscle myosin heavy chain gene (MYH13) maps to the cluster of fast and developmental myosin genes on chromosome 17.
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The regulatory light chain of nonmuscle myosin is encoded by spaghetti-squash, a gene required for cytokinesis in Drosophila.
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The role of F-actin and myosin in epithelial cell rheology.
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The role of calmodulin in the structure and regulation of phosphorylase kinase from rabbit skeletal muscle.
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The superfast extraocular myosin (MYH13) is localized to the innervation zone in both the global and orbital layers of rabbit extraocular muscle.
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Tissue interactions pattern the mesenchyme of the embryonic mouse lung.
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Triggering a cell shape change by exploiting preexisting actomyosin contractions.
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Triiodothyronine (T3) decreases binding to DNA by T3-receptor homodimers but not receptor-auxiliary protein heterodimers.
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Tyrosine phosphorylation of the beta3 cytoplasmic domain mediates integrin-cytoskeletal interactions.
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Unified biophysical mechanism for cell-shape oscillations and cell ingression.
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Unraveling the mysteries of chaperone interactions of the myosin head.
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Vascular biology and invasive cardiology. The streams are beginning to merge.
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Wound healing: The power of the purse string.
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ZIP kinase, a key regulator of myosin protein phosphatase 1.
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p38-MAPK induced dephosphorylation of alpha-tropomyosin is associated with depression of myocardial sarcomeric tension and ATPase activity.
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Keywords of People
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Bejsovec, Amy,
Associate Professor of Biology,
Biology
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Bennett, Vann,
George Barth Geller Distinguished Professor of Molecular Biology,
Duke Cancer Institute
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Erickson, Harold Paul,
Professor Emeritus of Cell Biology,
Cell Biology
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Kiehart, Daniel P.,
Professor of Biology,
Duke Science & Society
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Milano, Carmelo Alessio,
Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery,
Surgery, Cardiovascular and Thoracic Surgery