Myosin-Light-Chain Kinase
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Subject Areas on Research
- Acceleration of myosin light chain dephosphorylation and relaxation of smooth muscle by telokin. Synergism with cyclic nucleotide-activated kinase.
- Activation of four enzymes by two series of calmodulin mutants with point mutations in individual Ca2+ binding sites.
- Association of calmodulin and smooth muscle myosin light chain kinase: application of a label selection technique with trace acetylated calmodulin.
- Association of myosin light chain kinase with lymphocyte membrane-cytoskeleton complex.
- Autoregulation of enzymes by pseudosubstrate prototopes: myosin light chain kinase.
- Calcium/calmodulin transduces thrombin-stimulated secretion: studies in intact and minimally permeabilized human umbilical vein endothelial cells.
- Calmodulin activation of target enzymes. Consequences of deletions in the central helix.
- Calmodulin in endocrine cells.
- Calmodulin kinase II chimeras used to investigate the structural requirements for smooth muscle myosin light chain kinase autoinhibition and calmodulin-dependent activation.
- Calmodulin regulation of smooth-muscle myosin light-chain kinase.
- Calmodulin-cardiac troponin C chimeras. Effects of domain exchange on calcium binding and enzyme activation.
- Calmodulin-myosin light chain kinase inhibition changes fibroblast-populated collagen lattice contraction, cell migration, focal adhesion formation, and wound contraction.
- Changes in the structure of calmodulin induced by a peptide based on the calmodulin-binding domain of myosin light chain kinase.
- Characterization and analysis of an apparent autophosphorylation of chicken gizzard myosin light chain kinase.
- Characterization of cytoskeleton-enriched protein fraction of the trabecular meshwork and ciliary muscle cells.
- Characterization of the secondary structure of calmodulin in complex with a calmodulin-binding domain peptide.
- Chimeric calmodulin-cardiac troponin C proteins differentially activate calmodulin target enzymes.
- Domain organization of chicken gizzard myosin light chain kinase deduced from a cloned cDNA.
- Drosophila stretchin-MLCK is a novel member of the Titin/Myosin light chain kinase family.
- Estrogen stimulates the transient association of calmodulin and myosin light chain kinase with the chicken liver nuclear matrix.
- Fluorescence linked enzyme chemoproteomic strategy for discovery of a potent and selective DAPK1 and ZIPK inhibitor.
- Function and regulation of calmodulin in endocrine cells.
- Functional consequences of truncating amino acid side chains located at a calmodulin-peptide interface.
- Functional domains of chicken gizzard myosin light chain kinase.
- Functional significance of the central helix in calmodulin.
- Genetically engineered calmodulins differentially activate target enzymes.
- Hemochromatosis drives acute lethal intestinal responses to hyperyersiniabactin-producing Yersinia pseudotuberculosis.
- Hormonal regulation of a chicken oviduct messenger ribonucleic acid that shares a common domain with gizzard myosin light chain kinase.
- Identification of amino acids essential for calmodulin binding and activation of smooth muscle myosin light chain kinase.
- Intrasteric regulation of myosin light chain kinase: the pseudosubstrate prototope binds to the active site.
- Methionine to glutamine substitutions in the C-terminal domain of calmodulin impair the activation of three protein kinases.
- Molecular analysis of calmodulin and smooth muscle myosin light chain kinase.
- Myosin light chain kinase structure function analysis using bacterial expression.
- Ontogenesis of myosin light chain kinase mRNA and protein content in guinea pig tracheal smooth muscle.
- Phosphorylation of telokin by cyclic nucleotide kinases and the identification of in vivo phosphorylation sites in smooth muscle.
- Production and characterization of an antibody to myosin light chain kinase and intracellular localization of the enzyme.
- Proteolysis of smooth muscle myosin light chain kinase. Formation of inactive and calmodulin-independent fragments.
- Quantitation and significance of 125I-calmodulin binding to myosin light chain kinase and phosphorylase distributed on polyacrylamide gels.
- ROCK1 phosphorylates and activates zipper-interacting protein kinase.
- Regulation of protein kinases by pseudosubstrate prototopes.
- Regulation of smooth muscle myosin light chain kinase by calmodulin.
- Regulatory and structural motifs of chicken gizzard myosin light chain kinase.
- Regulatory cascades involving calmodulin-dependent protein kinases.
- Regulatory functions of calmodulin.
- Role of autophosphorylation in regulating calmodulin-dependent protein kinases.
- Secondary heart field contributes myocardium and smooth muscle to the arterial pole of the developing heart.
- Selective activation and inhibition of calmodulin-dependent enzymes by a calmodulin-like protein found in human epithelial cells.
- Site-specific phosphorylation and point mutations of telokin modulate its Ca2+-desensitizing effect in smooth muscle.
- Smoothelin-like 1 protein regulates myosin phosphatase-targeting subunit 1 expression during sexual development and pregnancy.
- Structural basis of the intrasteric regulation of myosin light chain kinases.
- Structure of the smooth muscle myosin light-chain kinase calmodulin-binding domain peptide bound to calmodulin.
- Target enzyme recognition by calmodulin: 2.4 A structure of a calmodulin-peptide complex.
- The calmodulin binding domain of chicken smooth muscle myosin light chain kinase contains a pseudosubstrate sequence.
- The role of the calponin homology domain of smoothelin-like 1 (SMTNL1) in myosin phosphatase inhibition and smooth muscle contraction.
- Three amino acid substitutions in domain I of calmodulin prevent the activation of chicken smooth muscle myosin light chain kinase.
- Three paradigms of airway smooth muscle hyperresponsiveness in young guinea pigs.
- Use of the 125I-labeled protein gel overlay technique to study calmodulin-binding proteins.
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Keywords of People
- Erickson, Harold Paul, James B. Duke Distinguished Professor of Cell Biology, Cell Biology
- Kiehart, Daniel P., Professor of Biology, Duke Science & Society