N-Formylmethionine

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  Subject Areas on Research

  • Activation of the respiratory burst enzyme in human polymorphonuclear leukocytes by chemoattractants and other soluble stimuli. Evidence that the same oxidase is activated by different transductional mechanisms. 
  • Alterations of new methylated phospholipid synthesis in the plasma membranes of macrophages exposed to chemoattractants. 
  • Amphotericin B alters the affinity and functional activity of the oligopeptide chemotactic factor receptor on human polymorphonuclear leukocytes. 
  • Chemoattractant receptor affinity reflects its ability to transduce different biological responses. 
  • Chemoattractant receptor functions in human polymorphonuclear leukocytes are divergently altered by membrane fluidizers. 
  • Chemotactically responsive and nonresposive forms of a continuous human monocyte cell line. 
  • Cyclic nucleotides regulate the morphologic alterations required for chemotaxis in monocytes. 
  • Demonstration of a chemotactic factor receptor on macrophages. 
  • Development of specific receptors for N-formylated chemotactic peptides in a human monocyte cell line stimulated with lymphokines. 
  • Guanine nucleotides modulate the binding affinity of the oligopeptide chemoattractant receptor on human polymorphonuclear leukocytes. 
  • Hormonal activation of adenylate cyclase in macrophage membranes is regulated by guanine nucleotides. 
  • Inhibitors of monocyte responses to chemotaxins are associated with human neoplasms. 
  • Polymorphonuclear leukocyte function in psoriasis: chemotaxis, chemokinesis, beta-adrenergic receptors, and proteolytic enzymes of polymorphonuclear leukocytes in the peripheral blood from psoriatic patients.