N-Formylmethionine Leucyl-Phenylalanine
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Subject Areas on Research
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5-Lipoxygenase products modulate the activity of the 85-kDa phospholipase A2 in human neutrophils.
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A chemoattractant receptor on macrophages exists in two affinity states regulated by guanine nucleotides.
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Acadesine inhibits neutrophil CD11b up-regulation in vitro and during in vivo cardiopulmonary bypass.
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Actin depolymerization and inhibition of capping induced by pentoxifylline in human lymphocytes and neutrophils.
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Activation of the respiratory burst enzyme in human polymorphonuclear leukocytes by chemoattractants and other soluble stimuli. Evidence that the same oxidase is activated by different transductional mechanisms.
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Alterations in stimulus-induced integrin expression in peripheral blood neutrophils of patients with diabetic retinopathy.
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Alterations of new methylated phospholipid synthesis in the plasma membranes of macrophages exposed to chemoattractants.
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Amphotericin B alters the affinity and functional activity of the oligopeptide chemotactic factor receptor on human polymorphonuclear leukocytes.
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Analysis of calcium homeostasis in activated human polymorphonuclear leukocytes. Evidence for two distinct mechanisms for lowering cytosolic calcium.
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C1q acts synergistically with phorbol dibutyrate to activate CR1-mediated phagocytosis by human mononuclear phagocytes.
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Calcium influx stimulates a second pathway for sustained diacylglycerol production in leukocytes activated by chemoattractants.
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Capillary zone electrophoresis-mass spectrometry using a coaxial continuous-flow fast atom bombardment interface.
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Changes in actin state and chemotactic peptide receptor expression in granulocytes during cytokine administration after autologous bone marrow transplantation.
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Characteristics of the chemotactic activity of heparin cofactor II proteolysis products.
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Characterization of C1q receptor expression on human phagocytic cells: effects of PDBu and fMLP.
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Characterization of an oligopeptide chemoattractant receptor on human blood monocytes using a new radioligand.
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Chemoattractant receptor affinity reflects its ability to transduce different biological responses.
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Chemoattractant receptor functions in human polymorphonuclear leukocytes are divergently altered by membrane fluidizers.
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Chemoattractant receptor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate in human polymorphonuclear leukocyte membranes. Requirement for a guanine nucleotide regulatory protein.
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Chemoattractant receptor-induced phosphorylation of L-selectin.
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Chemoattractant-elicited alterations of cAMP levels in human polymorphonuclear leukocytes require a Ca2+-dependent mechanism which is independent of transmembrane activation of adenylate cyclase.
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Chemoattractant-induced activation of c-fos gene expression in human monocytes.
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Chemoattractant-mediated stimulation of the respiratory burst in human polymorphonuclear leukocytes may require appearance of protein kinase activity in the cells' particulate fraction.
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Chemokine production by G protein-coupled receptor activation in a human mast cell line: roles of extracellular signal-regulated kinase and NFAT.
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Chemotactic peptide receptor-cytoskeletal interactions and functional correlations in differentiated HL-60 cells and human polymorphonuclear leukocytes.
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Chemotactically responsive and nonresposive forms of a continuous human monocyte cell line.
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Chemotaxis by a CNS macrophage, the microglia.
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Coexistence of a chemotactic factor and a retroviral P15E-related chemotaxis inhibitor in human tumor cell culture supernatants.
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Competition of hydrophobic peptides, cytotoxic drugs, and chemosensitizers on a common P-glycoprotein pharmacophore as revealed by its ATPase activity.
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Competitive, reversible inhibition of cytosolic phospholipase A2 at the lipid-water interface by choline derivatives that partially partition into the phospholipid bilayer.
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Cross-desensitization among receptors for platelet activating factor and peptide chemoattractants. Evidence for independent regulatory pathways.
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Cross-desensitization of chemoattractant receptors occurs at multiple levels. Evidence for a role for inhibition of phospholipase C activity.
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Cyclic nucleotides regulate the morphologic alterations required for chemotaxis in monocytes.
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Demonstration of a chemotactic factor receptor on macrophages.
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Depolarization of polymorphonuclear leukocytes by Porphyromonas (Bacteroides) gingivalis 381 in the absence of respiratory burst activation.
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Development of specific receptors for N-formylated chemotactic peptides in a human monocyte cell line stimulated with lymphokines.
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Differences in phosphorylation of formylpeptide and C5a chemoattractant receptors correlate with differences in desensitization.
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Differential activation of human neutrophil cytosolic phospholipase A2 and secretory phospholipase A2 during priming by 1,2-diacyl- and 1-O-alkyl-2-acylglycerols.
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Differential cross-regulation of the human chemokine receptors CXCR1 and CXCR2. Evidence for time-dependent signal generation.
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Differential regulation of formyl peptide and platelet-activating factor receptors. Role of phospholipase Cbeta3 phosphorylation by protein kinase A.
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Differentiation of U937 cells enables a phospholipase D-dependent pathway of cytosolic phospholipase A2 activation.
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Enhanced neutrophil chemiluminescence in familial Mediterranean fever.
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Evaluation of phospholipase C and D activity in stimulated human neutrophils using a phosphono analog of choline phosphoglyceride.
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Extensive hydrolysis of N-formyl-L-methionyl-L-leucyl-L-[3H] phenylalanine by human polymorphonuclear leukocytes. A potential mechanism for modulation of the chemoattractant signal.
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F-actin network formation in tethers and in pseudopods stimulated by chemoattractant.
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Fluorine-18 labeled chemotactic peptides: a potential approach for the PET imaging of bacterial infection.
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Functional high efficiency expression of cloned leukocyte chemoattractant receptor cDNAs.
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Granulocyte deformability and F-actin content: relationship to diabetes mellitus and retinopathy.
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Guanine nucleotides modulate the binding affinity of the oligopeptide chemoattractant receptor on human polymorphonuclear leukocytes.
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Hormonal activation of adenylate cyclase in macrophage membranes is regulated by guanine nucleotides.
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Human C5a modulates monocyte Fc and C3 receptor expression.
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Identification of a novel inositol bisphosphate isomer formed in chemoattractant stimulated human polymorphonuclear leukocytes.
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Immunologic consequences of acute ethanol ingestion in rats.
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Inhibitors of monocyte responses to chemotaxins are associated with human neoplasms.
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Labeling of peripheral blood polymorphonuclear leukocytes with indium-111: a new method for the quantitation of in-vivo accumulation of PMNLs in rabbit skin.
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Lack of correlation between induction of chemotactic peptide receptors and stimulus-induced actin polymerization in HL-60 cells treated with dibutyryl cyclic adenosine monophosphate or retinoic acid.
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Leukocyte activation by chemoattractant receptors: roles of a guanine nucleotide regulatory protein and polyphosphoinositide metabolism.
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Leukocyte chemoattractant receptors.
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Light scattering by polymorphonuclear leukocytes stimulated to aggregate under various pharmacologic conditions.
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Mechanisms of inflammation and leukocyte chemotaxis in the rheumatic diseases.
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Mechanisms of regulating the respiratory burst in leukocytes.
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Modulation of the free sphingosine levels in human neutrophils by phorbol esters and other factors.
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Modulation of the respiratory burst in human neutrophils by isoproterenol and dibutyryl cyclic AMP.
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Molecular mechanisms of leukocyte activation by chemoattractants.
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Multiple chromatographic forms of the formylpeptide chemoattractant receptor and their relationship to GTP-binding proteins.
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Nucleotide regulatory protein-mediated activation of phospholipase C in human polymorphonuclear leukocytes is disrupted by phorbol esters.
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Phosphorylation and calcium influx are not sufficient for the activation of cytosolic phospholipase A2 in U937 cells: requirement for a Gi alpha-type G-protein.
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Polymorphonuclear leukocyte function in psoriasis: chemotaxis, chemokinesis, beta-adrenergic receptors, and proteolytic enzymes of polymorphonuclear leukocytes in the peripheral blood from psoriatic patients.
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Potential role for a guanine nucleotide regulatory protein in chemoattractant receptor mediated polyphosphoinositide metabolism, Ca++ mobilization and cellular responses by leukocytes.
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Production of chemotactic peptides by neutrophil degradation of heparin cofactor II.
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RGS4 inhibits platelet-activating factor receptor phosphorylation and cellular responses.
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Receptor class desensitization of leukocyte chemoattractant receptors.
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Receptor-coupled activation of phosphoinositide-specific phospholipase C by an N protein.
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Regulation of inositol phosphate metabolism in chemoattractant-stimulated human polymorphonuclear leukocytes. Definition of distinct dephosphorylation pathways for IP3 isomers.
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Regulation of platelet-activating factor synthesis in human neutrophils by MAP kinases.
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Regulatory mechanisms of a chemoattractant receptor on human polymorphonuclear leukocytes.
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Regulatory mechanisms of a chemoattractant receptor on leukocytes.
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Signal transduction in cells following binding of chemoattractants to membrane receptors.
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Stimulus-specific effects of pentoxifylline on neutrophil CR3 expression, degranulation, and superoxide production.
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Studies on the fibronectin receptors of human peripheral blood leukocytes. Morphologic and functional characterization.
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Substance P primes human neutrophil activation: a mechanism for neurological regulation of inflammation.
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The NADPH oxidase of human polymorphonuclear leukocytes. Evidence for regulation by multiple signals.
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The effects of heparin cofactor II-derived chemotaxins on neutrophil actin conformation and cyclic AMP levels.
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The oligopeptide chemotactic factor receptor on human polymorphonuclear leukocyte membranes exists in two affinity states.
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Thrombin primes responsiveness of selective chemoattractant receptors at a site distal to G protein activation.
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Transendothelial migration enhances integrin-dependent human neutrophil chemokinesis.
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Tyrosine phosphorylation in human neutrophil.
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Unsaturated fatty acids and lipoxygenase products regulate phagocytic NADPH oxidase activity by a nondetergent mechanism.
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