NAD

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  Subject Areas on Research

  • A Flux Balance of Glucose Metabolism Clarifies the Requirements of the Warburg Effect. 
  • A bioluminescence method for the demonstration of regional glucose distribution in brain slices. 
  • A fixative for use in muscle histochemistry. 
  • A method for determination of pyridine nucleotides using a single extract. 
  • A new era for electron bifurcation. 
  • Abscisic acid activation of plasma membrane Ca(2+) channels in guard cells requires cytosolic NAD(P)H and is differentially disrupted upstream and downstream of reactive oxygen species production in abi1-1 and abi2-1 protein phosphatase 2C mutants. 
  • Adenine nucleotides of ischemic intestine do not reflect injury. 
  • Affinity chromatography of beta-hydroxybutyrate dehydrogenase on Nad and hydrophobic chain derivatives of sepharose. 
  • Age-related metabolic fatigue during low glucose conditions in rat hippocampus. 
  • Agonist-promoted coupling of the beta-adrenergic receptor with the guanine nucleotide regulatory protein of the adenylate cyclase system. 
  • Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. 
  • Assay of G-protein beta gamma-subunit complex by catalytic support of ADP-ribosylation of Go alpha. 
  • Biochemical changes during graded brain ischemia in gerbils. Part 2. Regional evaluation of cerebral blood flow and brain metabolites. 
  • CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response. 
  • Can adenine nucleotides predict primary nonfunction of the human liver homograft? 
  • Cerebral cortical microfluorometry at isosbestic wavelengths for correction of vascular artifact. 
  • Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice. 
  • Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. 
  • Deoxyribonucleic acid ligase. A steady state kinetic analysis of the reaction catalyzed by the enzyme from Escherichia coli. 
  • Deoxyribonucleic acid ligase. Isolation and physical characterization of the homogeneous enzyme from Escherichia coli. 
  • Disorders of respiratory burst termination. 
  • Effect of conformation on the binding of flavins to flavoenzymes. 
  • Effect of depolarizing concentrations of potassium on calcium uptake and metabolism in rat liver. 
  • Effect of transient focal ischemia of mouse brain on energy state and NAD levels: no evidence that NAD depletion plays a major role in secondary disturbances of energy metabolism. 
  • Effects of continuous-wave, pulsed, and sinusoidal-amplitude-modulated microwaves on brain energy metabolism. 
  • Effects of potassium on oxidative metabolism and seizures. 
  • Effects of relative hypoglycemia on LTP and NADH imaging in rat hippocampal slices. 
  • Elementary steps in the reaction mechanism of pyruvate dehydrogenase multienzyme complex from Escherichia coli: kinetics of flavin reduction. 
  • Enzyme/crystallins and extremely high pyridine nucleotide levels in the eye lens. 
  • Estradiol replacement enhances cocaine-stimulated locomotion in female C57BL/6 mice through estrogen receptor alpha. 
  • Experimental proof of the feasibility of using an angled fiber-optic probe for depth-sensitive fluorescence spectroscopy of turbid media. 
  • Exploiting metabolic differences in glioma therapy. 
  • Extremely high levels of NADPH in guinea pig lens: correlation with zeta-crystallin concentration. 
  • Flavohemoglobin denitrosylase catalyzes the reaction of a nitroxyl equivalent with molecular oxygen. 
  • Fluorometric monitoring of NADH levels in cerebral cortex: preliminary observations in human epilepsy. 
  • Focal differences in bioenergetic metabolism of atherosclerosis-susceptible and -resistant pigeon aortas. 
  • Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition. 
  • Hepatic sulfite oxidase. Congruency in mitochondria of prosthetic groups and activity. 
  • Heterologous desensitization of the liver adenylyl cyclase: analysis of the role of G-proteins. 
  • Identification of aberrantly regulated genes in diseased skin using the cDNA differential display technique. 
  • Identification of key amino acids responsible for the substantially higher affinities of human type 1 3beta-hydroxysteroid dehydrogenase/isomerase (3beta-HSD1) for substrates, coenzymes, and inhibitors relative to human 3beta-HSD2. 
  • Identification of the enzymatic mechanism of nitroglycerin bioactivation. 
  • In vivo multiphoton fluorescence lifetime imaging of protein-bound and free nicotinamide adenine dinucleotide in normal and precancerous epithelia. 
  • In vivo multiphoton microscopy of NADH and FAD redox states, fluorescence lifetimes, and cellular morphology in precancerous epithelia. 
  • Inhibiting glycolysis to reduce seizures: how it might work. 
  • Interaction between tissue oxygen tension and NADH imaging during synaptic stimulation and hypoxia in rat hippocampal slices. 
  • Interaction of reduced nicotinamide adenine dinucleotide with beef heart s-malate dehydrogenase. 
  • Interactions of nicotinamide adenine dinucleotides with varied states and forms of hemoglobin. 
  • Investigating the Sensitivity of NAD+-dependent Sirtuin Deacylation Activities to NADH. 
  • Isomeric N-alkylpyridylporphyrins and their Zn(II) complexes: inactive as SOD mimics but powerful photosensitizers. 
  • Kinetics of allosteric enzymes. 
  • Mechanism of nicotinamide-adenine dinucleotide binding to rabbit muscle glyceraldehyde 3-phosphate dehydrogenase. 
  • Metabolic Regulation by Lysine Malonylation, Succinylation, and Glutarylation. 
  • Metabolic control by sirtuins and other enzymes that sense NAD+, NADH, or their ratio. 
  • Metabolic mapping of MCF10A human breast cells via multiphoton fluorescence lifetime imaging of the coenzyme NADH. 
  • Metabolic responses differentiate between interictal, ictal and persistent epileptiform activity in intact, immature hippocampus in vitro. 
  • Methotrexate-induced alterations in beta-oxidation correlate with cognitive abilities in children with acute lymphoblastic leukemia. 
  • Microwave effects on energy metabolism of rat brain. 
  • Mitochondrial NADH as the bellwether of tissue O2 delivery. 
  • Mitochondrial metabolism sets the maximal limit of fuel-stimulated insulin secretion in a model pancreatic beta cell: a survey of four fuel secretagogues. 
  • Mitochondrial mutations in adenoid cystic carcinoma of the salivary glands. 
  • Mitochondrial sirtuins. 
  • Modification of Escherichia coli DNA ligase by cleavage with trypsin. 
  • Molecular basis of the biological function of molybdenum. Molybdenum-free xanthine oxidase from livers of tungsten-treated rats. 
  • Morphological and functional characterization of beta TC-6 cells--an insulin-secreting cell line derived from transgenic mice. 
  • Multiphoton redox ratio imaging for metabolic monitoring in vivo. 
  • NAD(P)H-dependent superoxide production by phagocytic vesicles from guinea pig and human granulocytes. 
  • NAD+ modulates p53 DNA binding specificity and function. 
  • NADH fluorescence and [K+]o changes during hippocampal electrical stimulation. 
  • NADH fluorescence, [K+]0 and oxygen consumption in cat cerebral cortex during direct cortical stimulation. 
  • NADH hyperoxidation correlates with enhanced susceptibility of aged rats to hypoxia. 
  • Neurologic deficit, blood flow and biochemical sequelae of reversible focal cerebral ischemia in cats. 
  • Nicotinamide adenine dinucleotide (NAD) and its metabolites inhibit T lymphocyte proliferation: role of cell surface NAD glycohydrolase and pyrophosphatase activities. 
  • Nicotinamide pre-treatment ameliorates NAD(H) hyperoxidation and improves neuronal function after severe hypoxia. 
  • Nonequivalence of the flavin adenine dinucleotide moieties of chicken liver xanthine dehydrogenase. 
  • On the occurrence of cytochrome P-450 and aryl hydrocarbon hydroxylase activity in rat brain. 
  • Optical redox ratio differentiates breast cancer cell lines based on estrogen receptor status. 
  • Oxidative metabolism during recurrent seizures in the penicillin treated hippocampus. 
  • Oxygen sufficiency in working rabbit papillary muscle at 35 degrees C. 
  • Peroxynitrite formation in nitric oxide-exposed submitochondrial particles: detection, oxidative damage and catalytic removal by Mn-porphyrins. 
  • Posttranslational modification of glyceraldehyde-3-phosphate dehydrogenase by S-nitrosylation and subsequent NADH attachment. 
  • Potassium, neuroglia, and oxidative metabolism in central gray matter. 
  • Purification and properties of chicken liver xanthine dehydrogenase. 
  • Purification and properties of the NAD+-dependent (type D) and O2-dependent (type O) forms of rat liver xanthine dehydrogenase. 
  • Pyruvate incubation enhances glycogen stores and sustains neuronal function during subsequent glucose deprivation. 
  • Reduced nicotinamide adenine dinucleotide phosphate-sulfite reductase of enterobacteria. 3. The Escherichia coli hemoflavoprotein: catalytic parameters and the sequence of electron flow. 
  • Regional assessment of energy-producing metabolism following prolonged complete ischemia of cat brain. 
  • Regional cerebral blood flow, glucose metabolism, protein synthesis, serum protein extravasation, and content of biochemical substrates in stroke-prone spontaneously hypertensive rats. 
  • Regional morphology and biochemistry in experimental brain abscesses. 
  • Relaxation spectrometry of biological systems. 
  • Reply: To PMID 22653543. 
  • Rhodamine 123 as a probe of transmembrane potential in isolated rat-liver mitochondria: spectral and metabolic properties. 
  • Role of NAD+ and mitochondrial sirtuins in cardiac and renal diseases. 
  • S-Adenosylhomocysteine hydrolase from human placenta. Affinity purification and characterization. 
  • SIRT3 regulates mitochondrial protein acetylation and intermediary metabolism. 
  • STRUCTURE AND FUNCTION OF IRON-FLAVOPROTEINS. 
  • Simultaneous monitoring of tissue PO2 and NADH fluorescence during synaptic stimulation and spreading depression reveals a transient dissociation between oxygen utilization and mitochondrial redox state in rat hippocampal slices. 
  • Single dose of glutamine enhances myocardial tissue metabolism, glutathione content, and improves myocardial function after ischemia-reperfusion injury. 
  • Skeletal muscle sarcoplasmic reticulum contains a NADH-dependent oxidase that generates superoxide. 
  • Sorbitol dehydrogenase of rat testis: changes of activity during development, after hypophysectomy and following gonadotrophic hormone administration. 
  • Structure and functional properties of the Bacillus subtilis transcriptional repressor Rex. 
  • Structure determination of selenomethionyl S-adenosylhomocysteine hydrolase using data at a single wavelength. 
  • Studies on the dissociation of flavin adenine dinucleotide from metalloflavoproteins. 
  • Superoxide generation by digitonin-stimulated guinea pig granulocytes. A basis for a continuous assay for monitoring superoxide production and for the study of the activation of the generating system. 
  • Temporal sequence and spatial distribution of early events of fertilization in single sea urchin eggs. 
  • The Warburg Effect: How Does it Benefit Cancer Cells? 
  • The cyanide-resistant alternative oxidases from the fungi Pichia stipitis and Neurospora crassa are monomeric and lack regulatory features of the plant enzyme. 
  • The design and operation of a dual-beal long-focal-length fluorometer for monitoring the oxidative metabolism in vivo. 
  • The differential effects of 200, 591, and 2,450 MHz radiation on rat brain energy metabolism. 
  • The effect of detergents on the reduction of tetrazolium salts. 
  • The effects of hyperthermia and hyperthermia plus microwaves on rat brain energy metabolism. 
  • The importance of binding energy in catalysis of hydride transfer by UDP-galactose 4-epimerase: a 13C and 15N NMR and kinetic study. 
  • The ionic and metabolic responses associated with neuronal depression of Leão's type in cerebral cortex and in hippocampal formation. 
  • The mechanism of conversion of rat liver xanthine dehydrogenase from an NAD+-dependent form (type D) to an O2-dependent form (type O). 
  • The nicotinamide adenine dinucleotides as allosteric effectors of human hemoglobin. 
  • Thermodynamic analysis of protein-ligand interactions in complex biological mixtures using a shotgun proteomics approach. 
  • Threshold relationship between cerebral blood flow, glucose utilization, and energy metabolites during development of stroke in gerbils. 
  • Using Cryo-EM to Map Small Ligands on Dynamic Metabolic Enzymes: Studies with Glutamate Dehydrogenase. 
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  Keywords of People

  • Hirschey, Matthew, Associate Professor, Pharmacology & Cancer Biology
  • Turner, Dennis Alan, Professor of Neurosurgery, Biomedical Engineering