NADP
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Subject Areas on Research
- A metabolomic endotype of bioenergetic dysfunction predicts mortality in critically ill patients with acute respiratory failure.
- Abscisic acid activation of plasma membrane Ca(2+) channels in guard cells requires cytosolic NAD(P)H and is differentially disrupted upstream and downstream of reactive oxygen species production in abi1-1 and abi2-1 protein phosphatase 2C mutants.
- Adding a positive charge at residue 46 of Drosophila alcohol dehydrogenase increases cofactor specificity for NADP+.
- Adenine nucleotides of ischemic intestine do not reflect injury.
- Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival.
- Anthracenedione activation by NADPH-cytochrome P-450 reductase; comparison with anthracyclines.
- Anthracenedione antineoplastic agent effects on drug metabolism in vitro and in vivo: relationship between structure and mechanism of inhibition.
- Chaperone-like activity of alpha-crystallin. The effect of NADPH on its interaction with zeta-crystallin.
- Chiral evasion and stereospecific antifolate resistance in Staphylococcus aureus.
- Compensatory responses to pyruvate carboxylase suppression in islet beta-cells. Preservation of glucose-stimulated insulin secretion.
- Concentrated RD114-pseudotyped MFGS-gp91phox vector achieves high levels of functional correction of the chronic granulomatous disease oxidase defect in NOD/SCID/beta -microglobulin-/- repopulating mobilized human peripheral blood CD34+ cells.
- Conformational selection or induced fit: a flux description of reaction mechanism.
- Consequences of chemical modifications on the free radical reactions of human hemoglobin.
- Coronary constriction to angiotensin II is enhanced by endothelial superoxide production in sheep programmed by dexamethasone.
- Dicoumarol-sensitive NADPH: phenanthrenequinone oxidoreductase in channel catfish (Ictalurus punctatus).
- Distribution of reaction intermediates on chicken liver fatty acid synthase.
- Elementary steps in the reaction mechanism of chicken liver fatty acid synthase. pH dependence of NADPH binding and isotope rate effect for beta-ketoacyl reductase.
- Elementary steps in the reaction mechanism of chicken liver fatty acid synthase: beta-ketoacyl reductase and enoyl reductase.
- Elementary steps in the reaction mechanism of chicken liver fatty acid synthase: reduced nicotinamide adenine dinucleotide phosphate binding and formation and reduction of acetoacetyl-enzyme.
- Enzyme/crystallins and extremely high pyridine nucleotide levels in the eye lens.
- Epimerization of an intermediary metabolite of norethynodrel by a 3 beta-hydroxy-delta 5(10)-steroid epimerase.
- Exploiting metabolic differences in glioma therapy.
- Extremely high levels of NADPH in guinea pig lens: correlation with zeta-crystallin concentration.
- Flavin interaction in NADPH-sulfite reductase.
- Fluorescence studies of chicken liver fatty acid synthase. Segmental flexibility and distance measurements.
- Fluorescence studies on the binding of reduced nicotinamide adenine dinucleotide phosphate to human hemoglobin A and its variant hemoglobin Providence.
- Functional evaluation of nonphagocytic NAD(P)H oxidases.
- Genetic variants in TKT and DERA in the nicotinamide adenine dinucleotide phosphate pathway predict melanoma survival.
- Identification and characterization of the enzymatic activity of zeta-crystallin from guinea pig lens. A novel NADPH:quinone oxidoreductase.
- Induction of nitric oxide in cultured microglia: evidence for a cytoprotective role.
- Inhibition of ERRα Prevents Mitochondrial Pyruvate Uptake Exposing NADPH-Generating Pathways as Targetable Vulnerabilities in Breast Cancer.
- Inhibition of microsomal oxidative drug metabolism by 1,4-bis (2-[(2-hydroxyethyl)amino]-ethylamino)-9,10-anthracenedione diacetate, a new antineoplastic agent.
- Interaction of spin-labeled nicotinamide adenine dinucleotide phosphate with chicken liver fatty acid synthase.
- Interactions of nicotinamide adenine dinucleotides with varied states and forms of hemoglobin.
- Investigation of reduced nicotinamide adenine dinucleotide phosphate and acyl-binding sites on avian fatty acid synthase.
- Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism.
- Isocitrate dehydrogenase is important for nitrosative stress resistance in Cryptococcus neoformans, but oxidative stress resistance is not dependent on glucose-6-phosphate dehydrogenase.
- Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells.
- Kinetic and nuclear magnetic resonance study of the interaction of NADP+ and NADPH with chicken liver fatty acid synthase.
- Lactate uptake contributes to the NAD(P)H biphasic response and tissue oxygen response during synaptic stimulation in area CA1 of rat hippocampal slices.
- MESH1 is a cytosolic NADPH phosphatase that regulates ferroptosis.
- MIBG inhibits respiration: potential for radio- and hyperthermic sensitization.
- Metabolic regulation of Drosophila apoptosis through inhibitory phosphorylation of Dronc.
- Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2.
- Mitochondrial NADP(H) deficiency due to a mutation in NADK2 causes dienoyl-CoA reductase deficiency with hyperlysinemia.
- Mitoxantrone: propensity for free radical formation and lipid peroxidation--implications for cardiotoxicity.
- Modulation of cytotoxicity of menadione sodium bisulfite versus leukemia L1210 by the acid-soluble thiol pool.
- Neuronal nitric-oxide synthase interaction with calmodulin-troponin C chimeras.
- Nitrofurantoin-stimulated proteolysis in human erythrocytes: a novel index of toxic insult by nitroaromatics.
- Nitrofurantoin-stimulated superoxide production by channel catfish (Ictalurus punctatus) hepatic microsomal and soluble fractions.
- Oxidative stress in human abdominal aortic aneurysms: a potential mediator of aneurysmal remodeling.
- Oxygen-coupled redox regulation of the skeletal muscle ryanodine receptor-Ca2+ release channel by NADPH oxidase 4.
- P450-dependent and nonenzymatic human liver microsomal defluorination of fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A), a sevoflurane degradation product.
- Pollutant particles enhanced H2O2 production from NAD(P)H oxidase and mitochondria in human pulmonary artery endothelial cells.
- Pyruvate dehydrogenase complex and nicotinamide nucleotide transhydrogenase constitute an energy-consuming redox circuit.
- Pyruvate incubation enhances glycogen stores and sustains neuronal function during subsequent glucose deprivation.
- Reduced nicotinamide adenine dinucleotide phosphate-sulfite reductase of enterobacteria. 3. The Escherichia coli hemoflavoprotein: catalytic parameters and the sequence of electron flow.
- Reduced nicotinamide adenine dinucleotide phosphate-sulfite reductase of enterobacteria. IV. The Escherichia coli hemoflavoprotein: subunit structure and dissociation into hemoprotein and flavoprotein components.
- Reduced nicotinamide adenine dinucleotide phosphate-sulfite reductase of enterobacteria. V. Studies with the Escherichia coli hemoflavoprotein depleted of flavin mononucleotide: distinct roles for the flavin adenine dinucleotide and flavin mononucleotide prosthetic groups in catalysis.
- Reduced nicotinamide adenine dinucleotide phosphate-sulfite reductase of enterobacteria. VI. The reaction of carbon monoxide with the Escherichia coli holoenzyme, the hemoprotein, and free siroheme.
- Regression of atherosclerosis in monkeys reduces vascular superoxide levels.
- Reply: To PMID 22653543.
- Role of aspartic acid 38 in the cofactor specificity of Drosophila alcohol dehydrogenase.
- Single-molecule and transient kinetics investigation of the interaction of dihydrofolate reductase with NADPH and dihydrofolate.
- Stereochemistry of the reactions catalyzed by chicken liver fatty acid synthase.
- Synergistic cytotoxicity between menadione and dicumarol vs. murine leukemia L1210.
- Synthetic lethality between HER2 and transaldolase in intrinsically resistant HER2-positive breast cancers.
- Systemic anti-tumour effects of local thermally sensitive liposome therapy.
- Temporal sequence and spatial distribution of early events of fertilization in single sea urchin eggs.
- The mechanism of discrimination between oxidized and reduced coenzyme in the aldehyde dehydrogenase domain of Aldh1l1.
- The mitochondrial 2-oxoglutarate carrier is part of a metabolic pathway that mediates glucose- and glutamine-stimulated insulin secretion.
- The nicotinamide adenine dinucleotides as allosteric effectors of human hemoglobin.
- The preparation of stereospecific tritium-labeled reduced nicotinamide adenine dinucleotide phosphate.
- Transcription factor Nrf2 hyperactivation in early-phase renal ischemia-reperfusion injury prevents tubular damage progression.
- Using genetically encoded fluorescent biosensors to interrogate ovarian cancer metabolism.
- Zeta-crystallin from guinea pig lens is capable of functioning catalytically as an oxidoreductase.
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Keywords of People
- Palmer, Gregory M., Associate Professor of Radiation Oncology, Radiation Oncology