Narcotics

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  Subject Areas on Research

  • A dopamine D1 receptor-dependent β-arrestin signaling complex potentially regulates morphine-induced psychomotor activation but not reward in mice. 
  • A pharmacodynamic model to investigate the structure-activity profile of a series of novel opioid analgesics. 
  • Abuse liability of medications used to treat attention-deficit/hyperactivity disorder (ADHD). 
  • Acute changes in cranial blood flow after cocaine hydrochloride. 
  • Adolescent morphine exposure affects long-term microglial function and later-life relapse liability in a model of addiction. 
  • Advances in the pharmacological management of breathlessness. 
  • Alterations in baseline activity and quinpirole sensitivity in putative dopamine neurons in the substantia nigra and ventral tegmental area after withdrawal from cocaine pretreatment. 
  • Anaphylactic and anaphylactoid reactions. A review. 
  • Ancient and recent positive selection transformed opioid cis-regulation in humans. 
  • Antagonist treatment of opioid withdrawal translational low dose approach. 
  • Application of continuous incisional infusion of local anesthetic after major pediatric urological surgery. 
  • Association Between Preoperative Narcotic Use with Perioperative Complication Rates, Patient Reported Pain Scores, and Ambulatory Status After Complex Spinal Fusion (≥5 Levels) for Adult Deformity Correction. 
  • Behavioral and molecular effects of dopamine D1 receptor stimulation during naloxone-precipitated morphine withdrawal. 
  • Behavioral assessment of narcotic detoxification fear. 
  • CSF distribution of opioids in animals and man. 
  • Cholinergic synaptic signaling mechanisms underlying behavioral teratogenicity: effects of nicotine, chlorpyrifos, and heroin converge on protein kinase C translocation in the intermedial part of the hyperstriatum ventrale and on imprinting behavior in an avian model. 
  • Chronic epidural bupivacaine-opioid infusion in intractable cancer pain. 
  • Chronic very low dose naltrexone administration attenuates opioid withdrawal expression. 
  • Cocaine sensitization in periadolescent and adult rats. 
  • Commentaries on Viewpoint: Why do some patients stop breathing after taking narcotics? Ventilatory chemosensitivity as a predictor of opioid-induced respiratory depression. 
  • Differences in Methadone Metabolism by CYP2B6 Variants. 
  • Differences in extracellular dopamine concentrations in the nucleus accumbens during response-dependent and response-independent cocaine administration in the rat. 
  • Disopyramide cross-reactivity in a commercial immunoassay reagent for methadone. 
  • Early outcomes following low dose naltrexone enhancement of opioid detoxification. 
  • Early-life experience decreases drug-induced reinstatement of morphine CPP in adulthood via microglial-specific epigenetic programming of anti-inflammatory IL-10 expression. 
  • Effect of administration of high dose intrathecal clonidine or morphine prior to sciatic nerve section on c-Fos expression in rat lumbar spinal cord. 
  • Effects of intermittent and continuous cocaine administration on dopamine release and uptake regulation in the striatum: in vitro voltammetric assessment. 
  • Effects of low-dose morphine on perceived sleep quality in patients with refractory breathlessness: A hypothesis generating study. 
  • Effects of sex and gonadectomy on cocaine metabolism in the rat. 
  • Effects of specific mu and kappa opiate tolerance and abstinence on hypothalamo-pituitary-adrenal axis secretion in the rat. 
  • Elevated mu-opioid receptor expression in the nucleus of the solitary tract accompanies attenuated withdrawal signs after chronic low dose naltrexone in opiate-dependent rats. 
  • Emergency nurses' knowledge of pain management principles. 
  • Enantiomeric metabolic interactions and stereoselective human methadone metabolism. 
  • G protein-coupled receptor kinase/beta-arrestin systems and drugs of abuse: psychostimulant and opiate studies in knockout mice. 
  • Grading the severity of chronic pain. 
  • Guidelines for endoscopy in pregnant and lactating women. 
  • HIV infection as a predictor of methadone maintenance outcomes in Chinese injection drug users. 
  • HIV risk behavior in opioid dependent adults seeking detoxification treatment: an exploratory comparison of heroin and oxycodone users. 
  • How do prescription opioid users differ from users of heroin or other drugs in psychopathology: results from the National Epidemiologic Survey on Alcohol and Related Conditions. 
  • Imagery reduces children's post-operative pain. 
  • Impact of staged InterStim implantation on the postoperative activities of daily living and pain. 
  • Infrequent illicit methadone use among stimulant-using patients in methadone maintenance treatment programs: a national drug abuse treatment clinical trials network study. 
  • Last Word on Viewpoint: Why do some patients stop breathing after taking narcotics? Ventilatory chemosensitivity as a predictor of opioid-induced respiratory depression. 
  • Long-term outcomes of protease inhibitor-based therapy in antiretroviral treatment-naive HIV-infected injection drug users on methadone maintenance programmes. 
  • Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: I. Evidence against CYP3A mediation of methadone clearance. 
  • Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: II. Ritonavir effects on CYP3A and P-glycoprotein activities. 
  • Mechanisms and management of bone pain. 
  • Metabolism of levo-alpha-Acetylmethadol (LAAM) by human liver cytochrome P450: involvement of CYP3A4 characterized by atypical kinetics with two binding sites. 
  • Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation. 
  • Minimally invasive microendoscopy-assisted transforaminal lumbar interbody fusion with instrumentation. 
  • Modulation of high alcohol drinking in the inbred Fawn-Hooded (FH/Wjd) rat strain: implications for treatment. 
  • Narcotic use and misuse in Crohn's disease. 
  • Neural grafting reverses prenatal drug-induced alterations in hippocampal PKC and related behavioral deficits. 
  • Neurobehavioral damage to cholinergic systems caused by prenatal exposure to heroin or phenobarbital: cellular mechanisms and the reversal of deficits by neural grafts. 
  • Neuropathic pain activates the endogenous kappa opioid system in mouse spinal cord and induces opioid receptor tolerance. 
  • Ontogeny of the behavioral response to dopamine agonists after chronic cocaine. 
  • Opiate withdrawal behavior after focal brain stimulation. 
  • Opiate withdrawal in the neonatal rat: relationship to duration of treatment and naloxone dose. 
  • Opiates transdeactivate chemokine receptors: delta and mu opiate receptor-mediated heterologous desensitization. 
  • Opiates, intracranial pressure, and autoregulation. 
  • Opioid-mediated facilitation of long-term potentiation at the lateral perforant path-dentate granule cell synapse. 
  • Oral modified release morphine for breathlessness in chronic heart failure: a randomized placebo-controlled trial. 
  • Outcome measures of a chronic pain program: a prospective statistical study. 
  • Partial cardiopulmonary bypass for core rewarming in profound accidental hypothermia. 
  • Perinatal effects of drugs of abuse. 
  • Postoperative Pain Scores and Narcotic Use in Robotic-assisted Versus Laparoscopic Hysterectomy for Endometrial Cancer Staging. 
  • Postoperative nausea and vomiting. A retrospective analysis in patients undergoing elective craniotomy. 
  • Potentiated opioid analgesia in norepinephrine transporter knock-out mice. 
  • Practical aspects of MAO inhibitor therapy. 
  • Preoperative lumbar epidural morphine improves postoperative analgesia and ventilatory function after transsternal thymectomy in patients with myasthenia gravis. 
  • Preventing and treating acute gout attacks across the clinical spectrum: a roundtable discussion. 
  • Pro: midazolam is the sedative of choice to supplement narcotic anesthesia. 
  • Randomised, double blind, placebo controlled crossover trial of sustained release morphine for the management of refractory dyspnoea. 
  • Reader questions benefit of nebulized opioids. 
  • Reduced Influence of Affective Disorders on 6-Week and 3-Month Narcotic Refills After Primary Complex Spinal Fusions for Adult Deformity Correction: A Single-Institutional Study. 
  • Removal of microglial-specific MyD88 signaling alters dentate gyrus doublecortin and enhances opioid addiction-like behaviors. 
  • Role for G protein-coupled receptor kinase in agonist-specific regulation of mu-opioid receptor responsiveness. 
  • Role of noradrenergic hyperactivity in neonatal opiate abstinence. 
  • Serendipitous rapid detoxification from opiates: the importance of time-dependent processes. 
  • Subarachnoid neurolytic block under general anesthesia in a 3-year-old with neuroblastoma. 
  • Survey of methadone-drug interactions among patients of methadone maintenance treatment program in Taiwan. 
  • Targeting microglial purinergic signaling to improve morphine analgesia. 
  • The effect of quinidine, used as a probe for the involvement of P-glycoprotein, on the intestinal absorption and pharmacodynamics of methadone. 
  • The kindling model of epilepsy: a critical review. 
  • The medullary dorsal horn: a target for the expression of opiate effects on the perceived intensity of noxious heat. 
  • Treatment considerations for elderly and frail patients with neuropathic pain. 
  • Trigeminal and dorsal root ganglion neurons express CCK receptor binding sites in the rat, rabbit, and monkey: possible site of opiate-CCK analgesic interactions. 
  • US primary care physicians' opinions about conscientious refusal: a national vignette experiment. 
  • Use of very low-dose naltrexone during opiate detoxification. 
  • Using a latent variable approach to inform gender and racial/ethnic differences in cocaine dependence: a National Drug Abuse Treatment Clinical Trials Network study. 
  • Voltage-dependent effects of opioid peptides on hippocampal CA3 pyramidal neurons in vitro. 
  • Why does social exclusion hurt? The relationship between social and physical pain. 
  • [Nphe1]nociceptin(1-13)-NH2 antagonizes nociceptin-induced hypotension, bradycardia, and hindquarters vasodilation in the anesthetized rat. 
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  Keywords of People

  • Warner, David Samuel, Distinguished Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology
  • Wray, Gregory Allan, Professor of Biology, Duke Innovation & Entrepreneurship
  • Wu, Li-Tzy, Professor in Psychiatry and Behavioral Sciences, Medicine, General Internal Medicine