Necrosis

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  Subject Areas on Research

  • A 40-year-old man with a perforated cheek. 
  • A 55-year-old man with fever, renal failure, and hip pain. 
  • A RNA interference screen identifies RIP3 as an essential inducer of TNF-induced programmed necrosis. 
  • A comparative study of the effect of arterial and venous occlusion after various periods of ischemia. 
  • A complicated case of ciliary body melanoma and glaucoma. 
  • A family of conserved bacterial effectors inhibits salicylic acid-mediated basal immunity and promotes disease necrosis in plants. 
  • A lethal association of congenital apnea with brainstem tegmental necrosis. 
  • A murine model of congenital toxoplasmic retinochoroiditis. 
  • A non-canonical type 2 immune response coordinates tuberculous granuloma formation and epithelialization. 
  • A realistic complication analysis of 70 sural artery flaps in a multimorbid patient group. 
  • A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses. 
  • A20 protects endothelial cells from TNF-, Fas-, and NK-mediated cell death by inhibiting caspase 8 activation. 
  • A20 protects mice from lethal liver ischemia/reperfusion injury by increasing peroxisome proliferator-activated receptor-alpha expression. 
  • Aberrant NF-kappaB activity is critical in focal necrosis formation of human glioblastoma by regulation of the expression of tissue factor. 
  • Activation in unipolar cardiac electrograms: a frequency analysis. 
  • Acute Esophageal Necrosis (Gurvits Syndrome) Presenting as Globus and Altered Phonation. 
  • Acute and Chronic Ophthalmic Involvement in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis - A Comprehensive Review and Guide to Therapy. II. Ophthalmic Disease. 
  • Acute local subcutaneous VEGF165 injection for augmentation of skin flap viability: efficacy and mechanism. 
  • Acute oesophageal necrosis in a young man with cocaine and alcohol abuse. 
  • An Animal Trial on the Optimal Time and Intensity of Exercise after Stroke. 
  • An unusual necrotizing dermatitis after a single application of topical benzoin and pressure bandage for enucleation of an eye. 
  • An unusual photoactivated skin eruption. Quinidine-induced livedo reticularis. 
  • An unusual presentation: renal tuberculosis. 
  • Angiopoietin-1 enhances skeletal muscle regeneration in mice. 
  • Anti-GM2 monoclonal antibodies induce necrosis in GM2-rich cultures of a human glioma cell line. 
  • Antiangiogenic treatment with three thrombospondin-1 type 1 repeats versus gemcitabine in an orthotopic human pancreatic cancer model. 
  • Apoptosis and hepatic allograft reperfusion injury. 
  • Apoptosis is not enhanced in primary mixed neuronal/glial cultures protected by isoflurane against N-methyl-D-aspartate excitotoxicity. 
  • Apoptosis of sinusoidal endothelial cells is a critical mechanism of preservation injury in rat liver transplantation. 
  • Arteritis with impaired renal function. 
  • Assessment of photosensitizer dosimetry and tissue damage assay for photodynamic therapy in advanced-stage tumors. 
  • Association between CK-MB Area Under the Curve and Tranexamic Acid Utilization in Patients Undergoing Coronary Artery Bypass Surgery. 
  • Bacillus cereus necrotizing cellulitis mimicking clostridial myonecrosis: case report and review of the literature. 
  • Bacterial pathogenesis: Pathogenic bacteria attack RHIM. 
  • Baseline NT-proBNP and biomarkers of inflammation and necrosis in patients with ST-segment elevation myocardial infarction: insights from the APEX-AMI trial. 
  • Biopsy of enlarging lesions after stereotactic radiosurgery for brain metastases frequently reveals radiation necrosis. 
  • Breast necrosis following use of the internal mammary artery for coronary artery bypass. 
  • Bronchial and bronchiolar fibrosis in rats exposed to 2,3-pentanedione vapors: implications for bronchiolitis obliterans in humans. 
  • Brown recluse spider envenomation: a prospective trial of hyperbaric oxygen therapy. 
  • Brown trabeculectomy bleb from necrotic iris melanocytoma. 
  • CFLAR/c-FLIPL: a star in the autophagy, apoptosis and necroptosis alliance. 
  • CYLD deubiquitinates RIP1 in the TNFα-induced necrosome to facilitate kinase activation and programmed necrosis. 
  • Calcium signals and calpain-dependent necrosis are essential for release of coxsackievirus B from polarized intestinal epithelial cells. 
  • Calpain mediates ischemic injury of the liver through modulation of apoptosis and necrosis. 
  • Can Vascular Patterns on Preoperative Magnetic Resonance Imaging Help Predict Skin Necrosis after Nipple-Sparing Mastectomy? 
  • Can chorio-retinal biopsy be justified? 
  • Carbohydrate restriction and lactate transporter inhibition in a mouse xenograft model of human prostate cancer. 
  • Cardiac cryosurgery: effects of myocardial temperature on cryolesion size. 
  • Case report: total parenteral nutrition extravasation associated with spinal cord compression and necrosis. 
  • Cell biology. RIPK3 takes another deadly turn. 
  • Cell biology: A guardian angel of cell integrity. 
  • Cell death in the pathogenesis of immune-mediated diseases: the role of HMGB1 and DAMP-PAMP complexes. 
  • Cell necrosis and endocytosis (apoptosis) in an embryonal rhabdomyosarcoma of the orbit. 
  • Changes in bone marrow pressure in response to hyperbaric exposure. 
  • Changing the diagnosis of acute myocardial infarction: implications for practice and clinical investigations. 
  • Clinical features, outcomes, and HLA risk factors associated with nitrofurantoin-induced liver injury. 
  • Clinicopathologic correlations in the oligodendroglioma. 
  • Clopidogrel loading with eptifibatide to arrest the reactivity of platelets: results of the Clopidogrel Loading With Eptifibatide to Arrest the Reactivity of Platelets (CLEAR PLATELETS) study. 
  • Collapsing glomerulopathy: an inflammatory podocytopathy? 
  • Colonic necrosis is an adverse prognostic factor in pancreatic necrosis. 
  • Combining necrosis and platelet markers for perfecting myocardial infarction rule out: how close are we? 
  • Comparison of the ultrasonic scalpel to CO2 laser and electrosurgery in terms of tissue injury and adhesion formation in a rabbit model. 
  • Comparison of thymocyte development and cytokine production in CD7-deficient, CD28-deficient and CD7/CD28 double-deficient mice. 
  • Composite tissue allotransplantation: classification of clinical acute skin rejection. 
  • Concordance of histopathologic and cytologic grading in musculoskeletal sarcomas: can grades obtained from analysis of the fine-needle aspirates serve as the basis for therapeutic decisions? 
  • Conjunctival necrosis following the administration of subconjunctival corticosteroid. 
  • Conjunctival necrosis following the administration of subconjunctival corticosteroid. 
  • Contextual tumor suppressor function of T cell death-associated gene 8 (TDAG8) in hematological malignancies. 
  • Conventional external beam radiotherapy for central nervous system malignancies. 
  • Correlation of [18F]-2-fluoro-deoxy-D-glucose positron emission tomography standard uptake values with the cellular composition of stage I nonsmall cell lung cancer. 
  • Cutting edge: RIPK1 Kinase inactive mice are viable and protected from TNF-induced necroptosis in vivo. 
  • Cyclophosphamide therapy of severe systemic necrotizing vasculitis. 
  • Cystine Deprivation Triggers Programmed Necrosis in VHL-Deficient Renal Cell Carcinomas. 
  • Cystine addiction of triple-negative breast cancer associated with EMT augmented death signaling. 
  • DAMP-Induced Allograft and Tumor Rejection: The Circle Is Closing. 
  • Damage- and pathogen-associated molecular patterns play differential roles in late mortality after critical illness. 
  • Defining Mastectomy Skin Flap Necrosis: A Systematic Review of the Literature and a Call for Standardization. 
  • Delayed myonecrosis in a leukemic patient with invasive group A streptococcal disease. 
  • Delayed radiation necrosis of the optic nerve. 
  • Demonstration and characterization of the hemoconcentrating effect of ascitic fluid that accumulates during hemorrhagic pancreatitis. 
  • Depletion of dendritic cells delays ovarian cancer progression by boosting antitumor immunity. 
  • Detection of bromobenzene-induced hepatocellular necrosis using magnetic resonance microscopy. 
  • Detection of necrosis by release of lactate dehydrogenase activity. 
  • Diagnosis and treatment of the systemic and cutaneous necrotizing vasculitis syndromes. 
  • Diagnostic criteria for degenerative, inflammatory, proliferative nonneoplastic and neoplastic liver lesions in medaka (Oryzias latipes): consensus of a National Toxicology Program Pathology Working Group. 
  • Differential roles of RIPK1 and RIPK3 in TNF-induced necroptosis and chemotherapeutic agent-induced cell death. 
  • Digital necrosis related to carboplatin and gemcitabine therapy in systemic sclerosis. 
  • Distinct Kinase-Independent Role of RIPK3 in CD11c+ Mononuclear Phagocytes in Cytokine-Induced Tissue Repair. 
  • Does terbutaline damage the developing heart? 
  • ETC-159, an Upstream Wnt inhibitor, Induces Tumour Necrosis via Modulation of Angiogenesis in Osteosarcoma. 
  • Editor's Highlight: Metformin Protects Against Acetaminophen Hepatotoxicity by Attenuation of Mitochondrial Oxidant Stress and Dysfunction. 
  • Effect of aerobic exercise on tumor physiology in an animal model of human breast cancer. 
  • Effect of clopidogrel with and without eptifibatide on tumor necrosis factor-alpha and C-reactive protein release after elective stenting: results from the CLEAR PLATELETS 1b study. 
  • Effect of freeze time during renal cryoablation: a swine model. 
  • Effect of pregabalin on cerebral outcome after cardiopulmonary bypass with deep hypothermic circulatory arrest in rats. 
  • Effects of cartilage impact with and without fracture on chondrocyte viability and the release of inflammatory markers. 
  • Effects of feeding Fusarium moniliforme culture material, containing known levels of fumonisin B1, on the young broiler chick. 
  • Efficacy of antisense morpholino oligomer targeted to c-myc in prostate cancer xenograft murine model and a Phase I safety study in humans. 
  • Emphysematous gastritis secondary to disseminated stronglyloidiasis. 
  • Endothelial microparticle levels are similar in acute ischemic stroke and stroke mimics due to activation and not apoptosis/necrosis. 
  • Endotracheal tube fastening device-related pressure necrosis of the upper lip. 
  • Etomoxir-induced PPARalpha-modulated enzymes protect during acute renal failure. 
  • Evaluation of a breast cancer nomogram for predicting risk of ipsilateral breast tumor recurrences in patients with ductal carcinoma in situ after local excision. 
  • Experimental evaluation of microsurgical techniques in small artery anastomoses. 
  • Expression of HIF-1alpha, CA IX, VEGF, and MMP-9 in surgically resected non-small cell lung cancer. 
  • Expression of mitochondrial membrane-linked SAB determines severity of sex-dependent acute liver injury. 
  • Expression of renal cell protein markers is dependent on initial mechanical culture conditions. 
  • Extent of tumor fibrosis/hyalinization and infarction following neoadjuvant radiation therapy is associated with improved survival in patients with soft-tissue sarcoma. 
  • Extracorporeal liver support for trauma-induced hepatic dysfunction. 
  • Extravascular extravasation of radiographic contrast media. Effects of conventional and low-osmolar agents in the rat thigh. 
  • Facial Filler Complications. 
  • Fatal hepatic necrosis after nivolumab as a bridge to liver transplant for HCC: Are checkpoint inhibitors safe for the pretransplant patient? 
  • Fatal hepatic necrosis following imatinib mesylate therapy. 
  • Fatal pulmonary bile embolism following acute acalculous cholecystitis. 
  • Fatal small-bowel necrosis and pulmonary hypertension in sickle cell disease. 
  • Findings on Surveillance Imaging After Preoperative Partial Breast Irradiation for Early Stage Breast Cancer. 
  • Fueling the flames: Mammalian programmed necrosis in inflammatory diseases. 
  • Functional complementation between FADD and RIP1 in embryos and lymphocytes. 
  • Functional expression of sodium-glucose transporters in cancer. 
  • Gastrointestinal pathology in patients with common variable immunodeficiency and X-linked agammaglobulinemia. 
  • Glutamine attenuation of cell death and inducible nitric oxide synthase expression following inflammatory cytokine-induced injury is dependent on heat shock factor-1 expression. 
  • Going up in flames: necrotic cell injury and inflammatory diseases. 
  • Granulocytic sarcoma in the absence of myeloid leukemia. 
  • Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis. 
  • Heat Shock Protein 70 (Hsp70) Suppresses RIP1-Dependent Apoptotic and Necroptotic Cascades. 
  • Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production. 
  • Heparin cofactor II in atherosclerotic lesions from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study. 
  • Hepatic histological findings in suspected drug-induced liver injury: systematic evaluation and clinical associations. 
  • Herpes simplex retinitis in the mouse. Clinicopathologic correlations. 
  • High LEF1 expression predicts adverse prognosis in chronic lymphocytic leukemia and may be targeted by ethacrynic acid. 
  • High-mobility group box 1 (HMGB1) protein: friend and foe. 
  • High-mobility group box-1 isoforms as potential therapeutic targets in sepsis. 
  • Histological and morphometric analysis of the effects of argon laser epilation. 
  • Human platelets exhibit chemotaxis using functional N-formyl peptide receptors. 
  • Humoral rejection of rat hepatic transplants by passive transfer of serum. 
  • Hyperbaric oxygen therapy in necrotising soft tissue infections: a study of patients in the United States Nationwide Inpatient Sample. 
  • Hypercoagulable states: a review. 
  • Hypertonic saline-augmented radiofrequency ablation of the VX-2 tumor implanted in the rabbit kidney: a short-term survival pilot study. 
  • Hypopyon and iris necrosis in angle-closure glaucoma. Report of two cases. 
  • Hypoxic Gene Expression of Donor Bronchi Linked to Airway Complications after Lung Transplantation. 
  • Identification of early recurrence of primary central nervous system tumors by [18F]fluorodeoxyglucose positron emission tomography. 
  • Images in clinical medicine. Mucormycosis of the hand and forearm. 
  • Impact of pemetrexed on intracranial disease control and radiation necrosis in patients with brain metastases from non-small cell lung cancer receiving stereotactic radiation. 
  • Implications of elevated cardiac troponin T in ambulatory patients with heart failure: a prospective analysis. 
  • Influence of platelet reactivity and inflammation on peri-procedural myonecrosis in East Asian patients undergoing elective percutaneous coronary intervention. 
  • Inhibition of leukocyte L-selectin function with a monoclonal antibody attenuates reperfusion injury to the rabbit ear. 
  • Inhibition of the Rac1 GTPase protects against nonlethal ischemia/reperfusion-induced necrosis and apoptosis in vivo. 
  • Integrin involvement in freeze resistance of androgen-insensitive prostate cancer. 
  • Interleukin-1 receptor activation aggravates autosomal dominant polycystic kidney disease by modulating regulated necrosis. 
  • Intestinal fatty acid binding protein (I-FABP) for the detection of strangulated mechanical small bowel obstruction. 
  • Intraoperative perfusion techniques can accurately predict mastectomy skin flap necrosis in breast reconstruction: results of a prospective trial. 
  • Intrathecal administration of a novel apoE-derived therapeutic peptide improves outcome following perinatal hypoxic-ischemic injury. 
  • Intrauterine epidermal necrosis. 
  • Iontophoretic delivery of dexamethasone phosphate for non-infectious, non-necrotising anterior scleritis, dose-finding clinical trial. 
  • Ischemic colitis in a young adult during sickle cell crisis: case report and review. 
  • Ischemic limb necrosis in septic shock: What is the role of high-dose vasopressor therapy? 
  • Kawasaki disease--a cause of vasculitis in children. 
  • Keto acid metabolites of branched-chain amino acids inhibit oxidative stress-induced necrosis and attenuate myocardial ischemia-reperfusion injury. 
  • Key roles of necroptotic factors in promoting tumor growth. 
  • Kidney lesions in Rocky Mountain spotted fever: a light-, immunofluorescence-, and electron-microscopic study. 
  • LDH isoenzymes and myocardial infarction in patients undergoing coronary bypass surgery: an excellent correlation. 
  • LI-RADS treatment response algorithm for detecting incomplete necrosis in hepatocellular carcinoma after locoregional treatment: a systematic review and meta-analysis using individual patient data. 
  • Laryngeal radionecrosis and hyperbaric oxygen therapy: report of 18 cases and review of the literature. 
  • Leiomyosarcoma of the kidney: a clinicopathologic study. 
  • Letter: Hepatic bridging--a semantic collapse. 
  • Liver transplantation as definitive therapy for complications after arterial embolization for hepatic manifestations of hereditary hemorrhagic telangiectasia. 
  • Long-term follow-up of auxiliary liver transplantation for fulminant hepatic failure. 
  • Loss of p16(INK4a) expression correlates with decreased survival in pediatric osteosarcomas. 
  • Loss-of-Function RNAi Screen to Identify Necrosis-Signaling Molecules. 
  • Lupus-related myelopathy: report of three cases and review of the literature. 
  • Macrophage deficiency of p38alpha MAPK promotes apoptosis and plaque necrosis in advanced atherosclerotic lesions in mice. 
  • Matrix metalloproteinases in patients with myocardial infarction and percutaneous revascularization. 
  • Mechanisms of ischemic injury are different in the steatotic and normal rat liver. 
  • Metabolic stress in autophagy and cell death pathways. 
  • Metabolism of chloroform by cytochrome P450 2E1 is required for induction of toxicity in the liver, kidney, and nose of male mice. 
  • Methamphetamine neurotoxicity: necrotic and apoptotic mechanisms and relevance to human abuse and treatment. 
  • Mice Lacking RIP3 Kinase are not Protected from Acute Radiation Syndrome. 
  • MicroRNA-23a Curbs Necrosis during Early T Cell Activation by Enforcing Intracellular Reactive Oxygen Species Equilibrium. 
  • Mito-tempo protects against acute liver injury but induces limited secondary apoptosis during the late phase of acetaminophen hepatotoxicity. 
  • Mitochondrial adaptations to obesity-related oxidant stress. 
  • Mitochondrial proteins that regulate apoptosis and necrosis are induced in mouse fatty liver. 
  • Modeling nuclear molecule release during in vitro cell death. 
  • Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. 
  • Morphology of hypoxia following cryoablation in a prostate cancer murine model: its relationship to necrosis, apoptosis and, microvessel density. 
  • Morphometric quantitation of tumor necrosis in stage 1 non-small cell carcinoma of lung: prognostic implications. 
  • Moving toward a new definition of acute myocardial infarction for the 21st century: status of the ESC/ACC consensus conference. European Society of Cardiology and American College of Cardiology. 
  • Multiple organ failure after ingestion of pennyroyal oil from herbal tea in two infants. 
  • Myocardial involvement in Rocky Mountain spotted fever. 
  • Myonecrosis following stent placement: association between impaired TIMI myocardial perfusion grade and MRI visualization of microinfarction. 
  • Necroptosis at a glance. 
  • Necroptosis-independent signaling by the RIP kinases in inflammation. 
  • Necroptosis: Mechanisms and Relevance to Disease. 
  • Necrosis and apoptosis of tumor cells in embolized meningiomas: histopathology and P53, BCL-2, CD-68 immunohistochemistry. 
  • Necrosis avidity of (99m)Tc(CO)3-labeled pamoic acid derivatives: synthesis and preliminary biological evaluation in animal models of necrosis. 
  • Necrosis-dependent and independent signaling of the RIP kinases in inflammation. 
  • Necrotizing Sweet Syndrome of the Upper Extremity After Elective Hand Surgery. 
  • Necrotizing fasciitis and myositis caused by group A streptococci. Epidemiology, diagnosis, and treatment of "flesh-eating bacteria". 
  • Necrotizing fasciitis of vulvar origin in diabetic patients. 
  • Necrotizing pulmonary aspergillosis with oxalosis. 
  • Neuroprotection from delayed postischemic administration of a metalloporphyrin catalytic antioxidant. 
  • Non-parenchymal cell responses in paracetamol (acetaminophen)-induced liver injury. 
  • Nonadditive effects of PAHs on Early Vertebrate Development: mechanisms and implications for risk assessment. 
  • Nonalcoholic fatty liver disease: implications for alcoholic liver disease pathogenesis. 
  • Nuclear grade and necrosis predict prognosis in malignant epithelioid pleural mesothelioma: a multi-institutional study. 
  • Oral and ophthalmic pathology of graft versus host disease in man: predictive value of the lip biopsy. 
  • Organophosphate-induced acetylcholinesterase inhibition and embryonic retinal cell necrosis in vivo in the teleost (Oryzias latipes). 
  • Outcomes after total skin-sparing mastectomy and immediate reconstruction in 657 breasts. 
  • PAR1 (Protease-Activated Receptor 1) Pepducin Therapy Targeting Myocardial Necrosis in Coronary Artery Disease and Acute Coronary Syndrome Patients Undergoing Cardiac Catheterization: A Randomized, Placebo-Controlled, Phase 2 Study. 
  • Parathyroid hormone secretion and target organ response in experimental acute pancreatitis. 
  • Pathogenesis of radiation-induced capsular contracture in tissue expander and implant breast reconstruction. 
  • Pathologic features of enteric infection with Yersinia enterocolitica. 
  • Pathologic response to preoperative chemotherapy in colorectal liver metastases: fibrosis, not necrosis, predicts outcome. 
  • Patterns of morphologic alteration in residual rectal carcinoma following preoperative chemoradiation and their association with long-term outcome. 
  • Pediatric cutaneous angiosarcomas: a clinicopathologic study of 10 cases. 
  • Pericardial synovial sarcoma: case report and literature review. 
  • Perioperative Treatment with a Prolyl Hydroxylase Inhibitor Reduces Necrosis in a Rat Ischemic Skin Flap Model. 
  • Phenylephrine induces delayed cardioprotection against necrosis without amelioration of stunning. 
  • Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. 
  • Physiological consequences of programmed necrosis, an alternative form of cell demise. 
  • Platelet-activating factor and endotoxin induce tumour necrosis factor gene expression in rat intestine and liver. 
  • Positive and negative phosphorylation regulates RIP1- and RIP3-induced programmed necrosis. 
  • Postradiation cerebellar necrosis mimicking tumor: MR appearance. 
  • Preoperative anemia predicts thrombosis and free flap failure in microvascular reconstruction. 
  • Primary closure of donor site in anterolateral cutaneous thigh free flap. 
  • Profound pressure necrosis: the culprit in delayed small-bowel perforations from jejunal tube extensions. 
  • Prognostic indicators for survival in stage I carcinoma of the lung: a histologic study of 47 surgically resected cases. 
  • Prognostic value of the diagnostic criteria distinguishing endometrial stromal sarcoma, low grade from undifferentiated endometrial sarcoma, 2 entities within the invasive endometrial stromal neoplasia family. 
  • Programmed necrosis in the cross talk of cell death and inflammation. 
  • Prolonged convection-enhanced delivery into the rat brainstem. 
  • Pseudomelanomas after conservative management of uveal melanoma. 
  • Pyroptosis triggers pore-induced intracellular traps (PITs) that capture bacteria and lead to their clearance by efferocytosis. 
  • Quality of life after treatment for pancreatitis. 
  • Quantitative proton magnetic resonance imaging in focal cerebral ischemia in rat brain. 
  • RIP1-dependent and independent effects of necrostatin-1 in necrosis and T cell activation. 
  • RIP3 induces apoptosis independent of pronecrotic kinase activity. 
  • RIP3: a molecular switch for necrosis and inflammation. 
  • RIPK1-RIPK3-MLKL-Associated Necroptosis Drives Leishmania infantum Killing in Neutrophils. 
  • RIPK3 Slams the Brake on Leukemogenesis. 
  • RIPK3: Beyond Necroptosis. 
  • Radiation dose-volume effects in the brain. 
  • Radiation therapy and hyperthermia improve the oxygenation of human soft tissue sarcomas. 
  • Radiologic-pathologic analysis of increased ethanol localization and ablative extent achieved by ethyl cellulose. 
  • Radiotherapy of soft tissue sarcomas in dogs. 
  • Reduced virulence of an extensively drug-resistant outbreak strain of Mycobacterium tuberculosis in a murine model. 
  • Reduction of myocardial ischemic injury following coronary intervention (the MC-1 to Eliminate Necrosis and Damage trial). 
  • Reduction of oral mucositis by filgrastim (r-metHuG-CSF) in patients receiving chemotherapy. 
  • Relation between previous lipid-lowering therapy and infarct size (creatine kinase-MB level) in patients presenting with acute myocardial infarction. 
  • Relationship between histopathology and in vitro clonogenicity in breast cancer. 
  • Release of DNA from dead and dying lymphocyte and monocyte cell lines in vitro. 
  • Renal cryoablation and radio frequency ablation: an evaluation of worst case scenarios in a porcine model. 
  • Reply: Is hepatocyte necrosis a good marker of donor liver viability during machine perfusion? 
  • Resolution of radiation necrosis with bevacizumab following radiation therapy for primary CNS lymphoma. 
  • Retinal toxicity of cyanoacrylate tissue adhesive in the rabbit. 
  • Revascularization of the ischemic hand with arterialization of the venous system. 
  • Review of Periorbital and Upper Face: Pertinent Anatomy, Aging, Injection Techniques, Prevention, and Management of Complications of Facial Fillers. 
  • Risuteganib Protects against Hydroquinone-induced Injury in Human RPE Cells. 
  • Role of macrophages in the generation of circulating blood nucleosomes from dead and dying cells. 
  • ST-elevation no myocardial infarction. 
  • SUPPORT-1 (Subjects Undergoing PCI and Perioperative Reperfusion Treatment): A Prospective, Randomized Trial of CMX-2043 in Patients Undergoing Elective Percutaneous Coronary Intervention. 
  • Schisis contributes to necrosis in experimental HSV-1 retinitis. 
  • Simultaneous thigh muscle metastasis from lung cancer and Escherichia coli gas producing myonecrosis. 
  • Spider bites: addressing mythology and poor evidence. 
  • Spontaneous necrosis and hemorrhage in an enlarged accessory spleen: CT demonstration. 
  • Studies on bromobenzene-induced hepatotoxicity using in vivo MR microscopy with surgically implanted RF coils. 
  • Subacute limb ischemia induces skeletal muscle injury in genetically susceptible mice independent of vascular density. 
  • Subcutaneous fat necrosis after paracentesis: Report of a case in a patient with acute pancreatitis. 
  • Superior gluteal artery in the extended iliofemoral approach. 
  • Sural flap delay procedure: a preliminary report. 
  • Surgical management of pancreatic necrosis: A practice management guideline from the Eastern Association for the Surgery of Trauma. 
  • Susceptibility to murine cytomegalovirus retinitis during progression of MAIDS: correlation with intraocular levels of tumor necrosis factor-alpha and interferon-gamma. 
  • Sympathetic nervous system inhibition increases hepatic progenitors and reduces liver injury. 
  • Systemic lupus erythematosus: a matter of life and death. 
  • TNF-induced necroptosis and PARP-1-mediated necrosis represent distinct routes to programmed necrotic cell death. 
  • TRPV1 receptors mediate particulate matter-induced apoptosis. 
  • Taxol-induced soft-tissue injury secondary to extravasation: characterization by histopathology and clinical course. 
  • Temporal lobe injury patterns following intensity modulated radiotherapy in a large cohort of nasopharyngeal carcinoma patients. 
  • Tetracycline-induced bile duct paucity and prolonged cholestasis. 
  • The "banked" TRAM: a method to insure mastectomy skin-flap survival. 
  • The Buruli type ulcer. 
  • The CO/HO system reverses inhibition of mitochondrial biogenesis and prevents murine doxorubicin cardiomyopathy. 
  • The Inflammatory Signal Adaptor RIPK3: Functions Beyond Necroptosis. 
  • The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis. 
  • The Real-World Effectiveness and Safety of Ustekinumab in the Treatment of Crohn's Disease: Results From the SUCCESS Consortium. 
  • The central effectors of cell death in the immune system. 
  • The diagnosis of brown recluse spider bite is overused for dermonecrotic wounds of uncertain etiology. 
  • The diagnosis of desmoplastic malignant mesothelioma and its distinction from fibrous pleurisy: a histologic and immunohistochemical analysis of 31 cases including p53 immunostaining. 
  • The effect of dexamethasone on the generation of plasma DNA from dead and dying cells. 
  • The extracellular release of DNA and HMGB1 from Jurkat T cells during in vitro necrotic cell death. 
  • The glucagon-like peptide-1 receptor agonist Exendin 4 has a protective role in ischemic injury of lean and steatotic liver by inhibiting cell death and stimulating lipolysis. 
  • The histologic response of soft tissue sarcoma to radiation therapy. 
  • The human myoepithelial cell displays a multifaceted anti-angiogenic phenotype. 
  • The molecular regulation of programmed necrotic cell injury. 
  • The necroptosis adaptor RIPK3 promotes injury-induced cytokine expression and tissue repair. 
  • The oncogenic microRNA miR-21 promotes regulated necrosis in mice. 
  • The origin of extracellular DNA during the clearance of dead and dying cells. 
  • The prepuce as a donor site for reconstruction of an extravasation injury to the foot in a newborn. 
  • The release of DNA into the plasma of mice following hepatic cell death by apoptosis and necrosis. 
  • The release of microparticles and mitochondria from RAW 264.7 murine macrophage cells undergoing necroptotic cell death in vitro. 
  • The role of macrophages in the in vitro generation of extracellular DNA from apoptotic and necrotic cells. 
  • The role of pre-ischaemic application of the nitric oxide donor spermine/nitric oxide complex in enhancing flap survival in a rat model. 
  • The significance of necrotic mediastinal lymph nodes on CT in patients with newly diagnosed Hodgkin disease. 
  • Therapy for granulomatous angiitis. 
  • Time to Steroid Independence After Laser Interstitial Thermal Therapy vs Medical Management for Treatment of Biopsy-Proven Radiation Necrosis Secondary to Stereotactic Radiosurgery for Brain Metastasis. 
  • Tissue expansion of the lower limb: complications in a cohort of 103 cases. 
  • Total nipple-areola complex necrosis in inferior pedicle breast reduction. 
  • Toxin injury-dependent switched expression between EF-1 alpha and its sister, S1, in rat skeletal muscle. 
  • Transgenic expression of the viral FLIP MC159 causes lpr/gld-like lymphoproliferation and autoimmunity. 
  • Treatment of cervical necrotizing fasciitis with hyperbaric oxygen therapy. 
  • Treatment of radiation-induced nervous system injury with heparin and warfarin. 
  • Tumor necrosis and cavitation after stereotactic body radiation therapy. 
  • Tumor necrosis factor increases mitochondrial oxidant production and induces expression of uncoupling protein-2 in the regenerating mice [correction of rat] liver. 
  • Tumor resection cavity administered iodine-131-labeled antitenascin 81C6 radioimmunotherapy in patients with malignant glioma: neuropathology aspects. 
  • Tumor-intrinsic and immune modulatory roles of receptor-interacting protein kinases. 
  • Usefulness of carotid intima-media thickness measurement as an indicator of generalized atherosclerosis: findings from autopsy analysis. 
  • Usefulness of combining necrosis and platelet markers in triaging patients presenting with chest pain to the emergency department. 
  • Using biomarkers to assess risk and consider treatment strategies in non-ST-segment elevation acute coronary syndromes. 
  • Vanilloid receptor activation by 2- and 10-microm particles induces responses leading to apoptosis in human airway epithelial cells. 
  • Variability in diagnostic threshold for comedo necrosis among breast pathologists: implications for patient eligibility for active surveillance trials of ductal carcinoma in situ. 
  • Verified bites by yellow sac spiders (genus Cheiracanthium) in the United States and Australia: where is the necrosis? 
  • Viral hemorrhagic septicemia virus, Ichthyophonus hoferi, and other causes of morbidity in Pacific herring Clupea pallasi spawning in Prince William Sound, Alaska, USA. 
  • Visualization of discrete microinfarction after percutaneous coronary intervention associated with mild creatine kinase-MB elevation. 
  • Vitamin E therapy of acute CCl4-induced hepatic injury in mice is associated with inhibition of nuclear factor kappa B binding. 
  • Wegener's granulomatosis involving the breast. Report of three cases and review of the literature. 
  • White matter lesions detected by magnetic resonance imaging after radiotherapy and high-dose chemotherapy in children with medulloblastoma or primitive neuroectodermal tumor. 
  • Work in progress: [18F] fluorodeoxyglucose and positron emission tomography in the evaluation of radiation necrosis of the brain. 
  • Workshop on cancer biometrics: identifying biomarkers and surrogates of cancer in patients: a meeting held at the Masur Auditorium, National Institutes of Health. 
  • Wound dressings: selecting the most appropriate type. 
  • c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis. 
  • hrp gene-dependent induction of hin1: a plant gene activated rapidly by both harpins and the avrPto gene-mediated signal. 
  • p53 functions in endothelial cells to prevent radiation-induced myocardial injury in mice. 
• 

  Keywords of People

  • Bradford, William Dalton, Professor of Pathology, Pathology
  • Charles, Hal Cecil, Adjunct Associate Professor in the Department of Radiology, Radiology
  • Chitneni, Satish K., Associate Professor in Radiology, Radiology
  • Laskowitz, Daniel Todd, Professor of Neurology, Duke Science & Society
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Milano, Carmelo Alessio, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Surgery, Cardiovascular and Thoracic Surgery
  • O'Connor, Christopher Michael, Adjunct Professor in the Department of Medicine, Medicine, Clinical Pharmacology
  • Patz Jr., Edward F., James and Alice Chen Distinguished Professor of Radiology, Pathology
  • Preminger, Glenn Michael, James F. Glenn, M.D. Distinguished Professor of Urology, Surgery, Urology