Neoplasm Proteins

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  Subject Areas on Research

  • 5' CpG island methylation of the FHIT gene is correlated with loss of gene expression in lung and breast cancer. 
  • A Recurrent De Novo Variant in NACC1 Causes a Syndrome Characterized by Infantile Epilepsy, Cataracts, and Profound Developmental Delay. 
  • A T cell intrinsic role of Id3 in a mouse model for primary Sjogren's syndrome. 
  • A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity. 
  • A copula approach for detecting prognostic genes associated with survival outcome in microarray studies. 
  • A genome-wide in vitro bacterial-infection screen reveals human variation in the host response associated with inflammatory disease. 
  • A loss-of-function RNA interference screen for molecular targets in cancer. 
  • A map of human cancer signaling. 
  • A natural history of melanoma: serial gene expression analysis. 
  • A polymorphism within the promoter of the TGFβ1 gene is associated with radiation sensitivity using an objective radiologic endpoint. 
  • A recellularized human colon model identifies cancer driver genes. 
  • A retrovirus carrying the promyelocyte-retinoic acid receptor PML-RARalpha fusion gene transforms haematopoietic progenitors in vitro and induces acute leukaemias. 
  • A review of hereditary breast cancer: from screening to risk factor modification. 
  • A small molecule inhibitor of isoprenylcysteine carboxymethyltransferase induces autophagic cell death in PC3 prostate cancer cells. 
  • A strategy for the rapid identification of phosphorylation sites in the phosphoproteome. 
  • A transcriptional repressor of osteopontin expression in the 4T1 murine breast cancer cell line. 
  • A truncated isoform of c-Mpl with an essential C-terminal peptide targets the full-length receptor for degradation. 
  • ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background. 
  • AURKA amplification, chromosome instability, and centrosome abnormality in human pancreatic carcinoma cells. 
  • Aberrant expression of cell-cycle regulatory proteins in human mesenchymal neoplasia. 
  • Abnormal Fhit expression in malignant and premalignant lesions of the cervix. 
  • Accumulation of beta ig-h3 gene product in corneas with granular dystrophy. 
  • Accumulation of p53 protein is frequent in ovarian cancers associated with BRCA1 and BRCA2 germline mutations. 
  • Accurate identification of proliferative index in melanocytic neoplasms with Melan-A/Ki-67 double stain. 
  • Acquisition of glutamine synthetase expression in human hepatocarcinogenesis: relation to disease recurrence and possible regulation by ubiquitin-dependent proteolysis. 
  • Activating mutations in STIM1 and ORAI1 cause overlapping syndromes of tubular myopathy and congenital miosis. 
  • Addressing cell-sourcing limitations with gene therapy. 
  • Agonists of G-Protein-Coupled Odorant Receptors Are Predicted from Chemical Features. 
  • Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition. 
  • Allele separation facilitates interpretation of potential splicing alterations and genomic rearrangements. 
  • An Eighteen-Gene Classifier Predicts Locoregional Recurrence in Post-Mastectomy Breast Cancer Patients. 
  • An aberrant NOTCH2-BCR signaling axis in B cells from patients with chronic GVHD. 
  • An in vitro assay procedure to test chemotherapeutic drugs on cells from human solid tumors. 
  • An inevitable dilemma: prenatal testing for mutations in the BRCA1 breast-ovarian cancer susceptibility gene. 
  • An integration of complementary strategies for gene-expression analysis to reveal novel therapeutic opportunities for breast cancer. 
  • An intronic splicing silencer causes skipping of the IIIb exon of fibroblast growth factor receptor 2 through involvement of polypyrimidine tract binding protein. 
  • Analysis of DNA mismatch repair proteins in human medulloblastoma. 
  • Analysis of novel and recurrent mutations responsible for the tricho-rhino-phalangeal syndromes. 
  • Androgen stimulation of gross cystic disease fluid protein and carcinoembryonic antigen in patients with metastatic breast carcinoma. 
  • Androgen-independent prostate cancer progression in the TRAMP model. 
  • Antigen-presenting cells pulsed with unfractionated tumor-derived peptides are potent tumor vaccines. 
  • Antiinflammatory effects of neoplasms. 
  • Antiinflammatory proteins associated with human and murine neoplasms. 
  • Application of Bayesian modeling of autologous antibody responses against ovarian tumor-associated antigens to cancer detection. 
  • Ascites Increases Expression/Function of Multidrug Resistance Proteins in Ovarian Cancer Cells. 
  • Association between Tumor Regression Rate and Gene Expression Profile after Iodine 125 Plaque Radiotherapy for Uveal Melanoma. 
  • Association between XPF polymorphisms and cancer risk: a meta-analysis. 
  • Association between germline variation in the FHIT gene and prostate cancer in Caucasians and African Americans. 
  • Association between novel PLCE1 variants identified in published esophageal cancer genome-wide association studies and risk of squamous cell carcinoma of the head and neck. 
  • Association of CHFR promoter methylation with disease recurrence in locally advanced colon cancer. 
  • Atypical teratoid/rhabdoid tumor of the central nervous system: a highly malignant tumor of infancy and childhood frequently mistaken for medulloblastoma: a Pediatric Oncology Group study. 
  • Autoantibodies against the cell surface-associated chaperone GRP78 stimulate tumor growth via tissue factor. 
  • Autocrine semaphorin3A stimulates alpha2 beta1 integrin expression/function in breast tumor cells. 
  • Autocrine stimulation of mas oncogene leads to altered growth control. 
  • B-CAM/LU expression and the role of B-CAM/LU activation in binding of low- and high-density red cells to laminin in sickle cell disease. 
  • BAALC and ERG expression levels are associated with outcome and distinct gene and microRNA expression profiles in older patients with de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study. 
  • BAALC expression predicts clinical outcome of de novo acute myeloid leukemia patients with normal cytogenetics: a Cancer and Leukemia Group B Study. 
  • BAX-mediated cell death affects early germ cell loss and incidence of testicular teratomas in Dnd1(Ter/Ter) mice. 
  • BP1, a new homeobox gene, is frequently expressed in acute leukemias. 
  • BRCA1 expression is not directly responsive to estrogen. 
  • BRCA1 mutations in primary breast and ovarian carcinomas. 
  • BRCA1 testing in families with hereditary breast-ovarian cancer. A prospective study of patient decision making and outcomes. 
  • BRCA2 mutations in primary breast and ovarian cancers. 
  • Baculovirus expression of functional P210 BCR-ABL oncogene product. 
  • Basal cell adhesion molecule/lutheran protein. The receptor critical for sickle cell adhesion to laminin. 
  • Bcl10 is not a target for frequent mutation in human carcinomas. 
  • Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers. 
  • Biochemical correlates of temozolomide sensitivity in pediatric solid tumor xenograft models. 
  • Bone morphogenetic protein-6 is a marker of serous acinar cell differentiation in normal and neoplastic human salivary gland. 
  • Breakpoints of the t(11;18)(q21;q21) in mucosa-associated lymphoid tissue (MALT) lymphoma lie within or near the previously undescribed gene MALT1 in chromosome 18. 
  • CC2D2A is mutated in Joubert syndrome and interacts with the ciliopathy-associated basal body protein CEP290. 
  • CD40 ligand is essential for generation of specific cytotoxic T cell responses in RNA-pulsed dendritic cell immunotherapy. 
  • Ca2+-activated Cl- channels at a glance. 
  • Calcium entry in skeletal muscle. 
  • Cancers of unknown primary origin (CUP) are characterized by chromosomal instability (CIN) compared to metastasis of know origin. 
  • Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy. 
  • Capromab Pendetide imaging of prostate cancer. 
  • Carbohydrate restriction and lactate transporter inhibition in a mouse xenograft model of human prostate cancer. 
  • Casein kinase 1α-dependent feedback loop controls autophagy in RAS-driven cancers. 
  • Cell adhesion protein expression in melanocytic matricoma. 
  • Cell adhesion to fibronectin and tenascin: quantitative measurements of initial binding and subsequent strengthening response. 
  • Cell cycle control of BRCA2. 
  • Cell cycle kinetic effects of tamoxifen on human breast cancer cells. Flow cytometric analyses of DNA content, BrdU labeling, Ki-67, PCNA, and statin expression. 
  • Cellular gene expression in papillomas of the choroid plexus from transgenic mice that express the simian virus 40 large T antigen. 
  • Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients. 
  • Characterization of prostatic epithelial cell lines derived from transgenic adenocarcinoma of the mouse prostate (TRAMP) model. 
  • Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer. 
  • Cisplatin and adriamycin resistance are associated with MutLalpha and mismatch repair deficiency in an ovarian tumor cell line. 
  • Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration. 
  • Comparative analysis of novel and conventional Hsp90 inhibitors on HIF activity and angiogenic potential in clear cell renal cell carcinoma: implications for clinical evaluation. 
  • Comparative effectiveness research in cancer genomics and precision medicine: current landscape and future prospects. 
  • Comparison of molecular markers in a cohort of patients with chronic myeloproliferative disorders. 
  • Consortium analysis of 7 candidate SNPs for ovarian cancer. 
  • Consortium analysis of gene and gene-folate interactions in purine and pyrimidine metabolism pathways with ovarian carcinoma risk. 
  • Construction and analysis of the NCI-EDRN breast cancer reference set for circulating markers of disease. 
  • Controlling lymphopoiesis with a combinatorial E-protein code. 
  • Conversion of diploidy to haploidy. 
  • Cotransfection of DC with TLR4 and MART-1 RNA induces MART-1-specific responses. 
  • Critical factors in basal cell adhesion molecule/lutheran-mediated adhesion to laminin. 
  • Cyclooxygenase-2 (COX-2) levels before and after chemotherapy: a study in rectal cancer. 
  • D6.1, a murine antimelanoma monoclonal antibody from congenitally athymic nude mice immunized with purified melanoma tumor-associated antigen. 
  • DEPDC1/LET-99 participates in an evolutionarily conserved pathway for anti-tubulin drug-induced apoptosis. 
  • Degradation of the tumor suppressor PML by Pin1 contributes to the cancer phenotype of breast cancer MDA-MB-231 cells. 
  • Deletion of cyclin-dependent kinase 4 inhibitor genes P15 and P16 in non-Hodgkin's lymphoma. 
  • Delivery of phosphorodiamidate morpholino antisense oligomers in cancer cells. 
  • Dendritic cells infected with a vaccinia vector carrying the human gp100 gene simultaneously present multiple specificities and elicit high-affinity T cells reactive to multiple epitopes and restricted by HLA-A2 and -A3. 
  • Detection and localization of surgically resectable cancers with a multi-analyte blood test. 
  • Detection of BRCA1 mutations in women with early-onset ovarian cancer by use of the protein truncation test. 
  • Determination of proliferation index in advanced ovarian cancer using quantitative image analysis. 
  • Determination of proliferation index with MIB-1 in advanced ovarian cancer using quantitative image analysis. 
  • Development of a radioimmunoassay for fetal antigen 2. 
  • Differential gene expression patterns in HER2/neu-positive and -negative breast cancer cell lines and tissues. 
  • Differentiation of human T lymphocytes. I. Acquisition of a novel human cell surface protein (p80) during normal intrathymic T cell maturation. 
  • Distinct roles for c-Myb and core binding factor/polyoma enhancer-binding protein 2 in the assembly and function of a multiprotein complex on the TCR delta enhancer in vivo. 
  • Distribution and dosimetry of I-123-labeled monoclonal antibody 81C6 in patients with anaplastic glioma. 
  • Diverse AR-V7 cistromes in castration-resistant prostate cancer are governed by HoxB13. 
  • Do serum biomarkers really measure breast cancer? 
  • Does prior benign prostate biopsy predict outcome for patients treated with radical perineal prostatectomy? 
  • Double antibody radioimmunoassay for monitoring metastatic breast cancer. 
  • Dying tumor cells stimulate proliferation of living tumor cells via caspase-dependent protein kinase Cδ activation in pancreatic ductal adenocarcinoma. 
  • Dysregulation of hemostasis by cancer. 
  • ELAV tumor antigen, Hel-N1, increases translation of neurofilament M mRNA and induces formation of neurites in human teratocarcinoma cells. 
  • Ectopic expression of interferon regulatory factor-1 promotes human breast cancer cell death and results in reduced expression of survivin. 
  • Effect of growth conditions on the activity of ornithine decarboxylase in cultured hepatoma cells. I. Effect of amino acid supply. 
  • Effect of inhibitors of proteolytic enzymes on the growth of normal and polyoma transformed BHK cells. 
  • Effects of tumor growth on host defenses. 
  • Elevated expression of PCGEM1, a prostate-specific gene with cell growth-promoting function, is associated with high-risk prostate cancer patients. 
  • Elevated expression of a subset of interferon inducible genes in primary bone marrow cells expressing p185 Bcr-Abl versus p210 Bcr-Abl by DNA microarray analysis. 
  • Endocrine therapy in metastatic breast cancer. 
  • Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells. 
  • Epithelial cells are an important source of tenascin in normal and malignant human breast tissue. 
  • Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. 
  • Evaluation of expression based markers for the detection of breast cancer cells. 
  • Evaluation of microsatellite instability, hMLH1 expression and hMLH1 promoter hypermethylation in defining the MSI phenotype of colorectal cancer. 
  • Exome genotyping arrays to identify rare and low frequency variants associated with epithelial ovarian cancer risk. 
  • Exome-wide Association Study Identifies GREB1L Mutations in Congenital Kidney Malformations. 
  • Expanding CEP290 mutational spectrum in ciliopathies. 
  • Expansion of tumor-T cell pairs from fine needle aspirates of melanoma metastases. 
  • Expression and prognostic impact of lncRNAs in acute myeloid leukemia. 
  • Expression of five selected human mismatch repair genes simultaneously detected in normal and cancer cell lines by a nonradioactive multiplex reverse transcription-polymerase chain reaction. 
  • Expression of osteocalcin and its transcriptional regulators core-binding factor alpha 1 and MSX2 in osteoid-forming tumours. 
  • Expression of the protein tyrosine phosphatase, phosphatase of regenerating liver 1, in the outer segments of primate cone photoreceptors. 
  • Expression of three forms of melanoma growth stimulating activity (MGSA)/gro in human retinal pigment epithelial cells. 
  • Expression of tumor-suppressor genes interferon regulatory factor 1 and death-associated protein kinase in primitive acute myelogenous leukemia cells. 
  • Expression profiling of in vivo ductal carcinoma in situ progression models identified B cell lymphoma-9 as a molecular driver of breast cancer invasion. 
  • FRA1 promotes squamous cell carcinoma growth and metastasis through distinct AKT and c-Jun dependent mechanisms. 
  • Factor VIII Arg2304 --> His binds to phosphatidylserine and is a functional cofactor in the factor X-ase complex. 
  • Familial breast-ovarian cancer syndromes: BRCA1 and BRCA2. 
  • Fasciola hepatica: molecular cloning, nucleotide sequence, and expression of a gene encoding a polypeptide homologous to a Schistosoma mansoni fatty acid-binding protein. 
  • Fibulin-3 is a novel TGF-β pathway inhibitor in the breast cancer microenvironment. 
  • Fine-needle aspiration diagnosis of psammomatous melanotic schwannoma. 
  • Flt3 is dispensable to the Hoxa9/Meis1 leukemogenic cooperation. 
  • Frequency of MART-1/MelanA and gp100/PMel17-specific T cells in tumor metastases and cultured tumor-infiltrating lymphocytes. 
  • Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors. 
  • Gastric cancer-molecular and clinical dimensions. 
  • Gene expression signatures and outcome prediction in mature B-cell malignancies. 
  • Genetic analysis of sinonasal adenocarcinoma phenotypes: distinct alterations of histogenetic significance. 
  • Genetic interactions between Shox2 and Hox genes during the regional growth and development of the mouse limb. 
  • Genetic polymorphism at the glutathione S-transferase (GST) P1 locus is a breast cancer risk modifier. 
  • Genetic polymorphisms of selected DNA repair genes, estrogen and progesterone receptor status, and breast cancer risk. 
  • Genetic susceptibility testing and prophylactic oophorectomy. 
  • Genetic variants in the vitamin D pathway genes VDBP and RXRA modulate cutaneous melanoma disease-specific survival. 
  • Genetic variations in TERT-CLPTM1L genes and risk of squamous cell carcinoma of the head and neck. 
  • Genetics of hyperuricemia and gout: implications for the present and future. 
  • Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemia. 
  • Genome-wide significant risk associations for mucinous ovarian carcinoma. 
  • Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism. 
  • Genomic FHIT analysis in RER+ and RER- adenocarcinomas of the pancreas. 
  • Genomic landscapes of breast fibroepithelial tumors. 
  • Genomic signatures in non-small-cell lung cancer: targeting the targeted therapies. 
  • Global analysis of protein folding thermodynamics for disease state characterization. 
  • Global expression analysis of cancer/testis genes in uterine cancers reveals a high incidence of BORIS expression. 
  • Global identification of MLL2-targeted loci reveals MLL2's role in diverse signaling pathways. 
  • Glutamine attenuates lung injury and improves survival after sepsis: role of enhanced heat shock protein expression. 
  • Glycoconjugates and tumor metastasis. 
  • Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1. 
  • Gremlin is overexpressed in lung adenocarcinoma and increases cell growth and proliferation in normal lung cells. 
  • HIN-1, a putative cytokine highly expressed in normal but not cancerous mammary epithelial cells. 
  • HSPB1 gene polymorphisms predict risk of mortality for US patients after radio(chemo)therapy for non-small cell lung cancer. 
  • Heavy LIFting: tumor promotion and radioresistance in NPC. 
  • Hereditary ovarian cancer in Ashkenazi Jews. 
  • High frequency of hypermethylation at the 14-3-3 sigma locus leads to gene silencing in breast cancer. 
  • High-dose, single-agent irinotecan as first-line therapy in the treatment of metastatic colorectal cancer. 
  • Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA. 
  • Human adipocyte lipid-binding protein: purification of the protein and cloning of its complementary DNA. 
  • Human colorectal carcinomas specifically accumulate Mr 42,000 ubiquitin-conjugated cytokeratin 8 fragments. 
  • Human dendritic cells, pulsed with either melanoma tumor cell lysates or the gp100 peptide(280-288), induce pairs of T-cell cultures with similar phenotype and lytic activity. 
  • Human medullary thymocyte p80 antigen and In(Lu)-related p80 antigen reside on the same protein. 
  • Human promyelocytic leukemia HL-60 cell proliferation and c-myc protein expression are inhibited by an antisense pentadecadeoxynucleotide targeted against c-myc mRNA. 
  • Human red cell antigens. V. Expression of In(Lu)-related p80 antigens by recessive-type Lu(a-b-) red cells. 
  • Human syngeneic intestinal transplantation: evaluation of enterocyte viability with serum levels of intestinal fatty acid binding protein. 
  • Hypermethylation of 14-3-3 sigma (stratifin) is an early event in breast cancer. 
  • Hypomorphic mutations in syndromic encephalocele genes are associated with Bardet-Biedl syndrome. 
  • IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation. 
  • Identification of a new subclass of Alu DNA repeats which can function as estrogen receptor-dependent transcriptional enhancers. 
  • Identification of a secreted Mr 95,000 glycoprotein in human melanocytes and melanomas by a melanocyte specific monoclonal antibody. 
  • Identification of cellular proteins required for simian virus 40 DNA replication. 
  • Identification of resting cells by dual-parameter flow cytometry of statin expression and DNA content. 
  • Identification of the breast cancer susceptibility gene BRCA2. 
  • Imaging molecular pathways: reporter genes. 
  • Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL. 
  • Immune (gamma) interferon production by a murine T cell lymphoma: requirements for macromolecular synthesis and lack of relationship with cell cycle. 
  • Immune response of chimpanzee to purified melanoma 250 kilodalton tumor-associated antigen. 
  • Immune selection after antigen-specific immunotherapy of melanoma. 
  • Immunolocalization of beta ig-h3 protein in 5q31-linked corneal dystrophies and normal corneas. 
  • Immunophenotype and molecular characterisation of adenocarcinoma of the small intestine. 
  • Immunotherapy and monoclonal antibody therapies. 
  • Immunotherapy for malignant melanoma with a tumor cell vaccine. 
  • Impact of Polymorphic Variations of Gemcitabine Metabolism, DNA Damage Repair, and Drug-Resistance Genes on the Effect of High-Dose Chemotherapy for Relapsed or Refractory Lymphoid Malignancies. 
  • Impaired immune responses and B-cell proliferation in mice lacking the Id3 gene. 
  • Implication of mitochondrial involvement in apoptotic activity of fragile histidine triad gene: application of synchronous luminescence spectroscopy. 
  • In vivo evaluation of cell mediated immunity against human melanoma. 
  • In vivo tumor localization using tumor-specific monkey xenoantibody, alloantibody, and murine monoclonal xenoantibody. 
  • In-depth proteomic analysis of nonsmall cell lung cancer to discover molecular targets and candidate biomarkers. 
  • Increased vaccine-specific T cell frequency after peptide-based vaccination correlates with increased susceptibility to in vitro stimulation but does not lead to tumor regression. 
  • Increasing prostate-specific antigen profile following definitive radiation therapy for localized prostate cancer: clinical observations. 
  • Induction of anti-melanoma CTL response using DC transfected with mutated mRNA encoding full-length Melan-A/MART-1 antigen with an A27L amino acid substitution. 
  • Induction of lethal experimental allergic encephalomyelitis in nonhuman primates and guinea pigs with human glioblastoma multiforme tissue. 
  • Inhibition of constitutive NF-kappa B activity by I kappa B alpha M suppresses tumorigenesis. 
  • Inhibition of mitogen-activated protein kinase and phosphatidylinositol 3-kinase activity in MCF-7 cells prevents estrogen-induced mitogenesis. 
  • Initial testing (stage 1) of the investigational mTOR kinase inhibitor MLN0128 by the pediatric preclinical testing program. 
  • Initial testing (stage 1) of the notch inhibitor PF-03084014, by the pediatric preclinical testing program. 
  • Initial testing of the VEGFR inhibitor AZD2171 by the pediatric preclinical testing program. 
  • Inside-out Ca(2+) signalling prompted by STIM1 conformational switch. 
  • Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway. 
  • Interferon Regulatory Factor 1 (IRF-1) induces p21(WAF1/CIP1) dependent cell cycle arrest and p21(WAF1/CIP1) independent modulation of survivin in cancer cells. 
  • Interferon-gamma reduces melanosomal antigen expression and recognition of melanoma cells by cytotoxic T cells. 
  • Invasion of the bladder by transitional cell carcinoma: its relation to histologic grade and expression of p53, MIB-1, c-erb B-2, epidermal growth factor receptor, and bcl-2. 
  • Isolation and initial characterization of the BRCA2 promoter. 
  • KIND1 Loss Sensitizes Keratinocytes to UV-Induced Inflammatory Response and DNA Damage. 
  • KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation. 
  • Ki-67 expression is a prognostic marker of prostate cancer recurrence after radical prostatectomy. 
  • Kinetics of TCR use in response to repeated epitope-specific immunization. 
  • L-selectin binds to P-selectin glycoprotein ligand-1 on leukocytes: interactions between the lectin, epidermal growth factor, and consensus repeat domains of the selectins determine ligand binding specificity. 
  • Labeling monoclonal antibodies and F(ab')2 fragments with the alpha-particle-emitting nuclide astatine-211: preservation of immunoreactivity and in vivo localizing capacity. 
  • Labeling proteins using aryl iodide acylation agents: influence of meta vs para substitution on in vivo stability. 
  • Lack of utility of intestinal fatty acid binding protein levels in predicting intestinal allograft rejection. 
  • Large-Scale Analysis of Breast Cancer-Related Conformational Changes in Proteins Using Limited Proteolysis. 
  • Large-Scale Analysis of Breast Cancer-Related Conformational Changes in Proteins Using SILAC-SPROX. 
  • Laser scanning cytometry evaluation of MART-1, gp100, and HLA-A2 expression in melanoma metastases. 
  • Left-Biased Spermatogenic Failure in 129/SvJ Dnd1Ter/+ Mice Correlates with Differences in Vascular Architecture, Oxygen Availability, and Metabolites. 
  • Ligation of cell surface GRP78 with antibody directed against the COOH-terminal domain of GRP78 suppresses Ras/MAPK and PI 3-kinase/AKT signaling while promoting caspase activation in human prostate cancer cells. 
  • Limitations of tissue microarrays in the evaluation of focal alterations of bcl-2 and p53 in whole mount derived prostate tissues. 
  • Localization and quantitation of hexabrachion (tenascin) in skin, embryonic brain, tumors, and plasma. 
  • Loss of Fhit expression in non-small-cell lung cancer: correlation with molecular genetic abnormalities and clinicopathological features. 
  • Loss of KAI1 expression in the progression of colorectal cancer. 
  • Loss of heterozygosity of the putative prostate cancer susceptibility gene HPC2/ELAC2 is uncommon in sporadic and familial prostate cancer. 
  • Loss of nuclear localized and tyrosine phosphorylated Stat5 in breast cancer predicts poor clinical outcome and increased risk of antiestrogen therapy failure. 
  • Lung cancer staging: proteomics. 
  • MAGE-1-specific precursor cytotoxic T-lymphocytes present among tumor-infiltrating lymphocytes from a patient with breast cancer: characterization and antigen-specific activation. 
  • MEN1 gene mutation analysis of high-grade neuroendocrine lung carcinoma. 
  • MGSA/GRO transcription is differentially regulated in normal retinal pigment epithelial and melanoma cells. 
  • MIBG inhibits respiration: potential for radio- and hyperthermic sensitization. 
  • MUC1 mucin expression as a marker of progression and metastasis of human colorectal carcinoma. 
  • Malignant fibrous histiocytoma of the lateral conjunctiva and anterior orbit. 
  • Malignant transformation of the human endometrium is associated with overexpression of lactoferrin messenger RNA and protein. 
  • Managing hereditary ovarian cancer risk. 
  • Mas oncogene receptor coupling and peptide specificity in Balb 3T3 and vascular smooth muscle cells. 
  • Mechanical stiffness grades metastatic potential in patient tumor cells and in cancer cell lines. 
  • Melanoma, a tumor based on a mutant stem cell? 
  • Melastatin expression and prognosis in cutaneous malignant melanoma. 
  • Mesenchymal high-grade glioma is maintained by the ID-RAP1 axis. 
  • Metastatic clear cell renal cell carcinoma: Circulating biomarkers to guide antiangiogenic and immune therapies. 
  • Methylthioadenosine phosphorylase and activated insulin-like growth factor-1 receptor/insulin receptor: potential therapeutic targets in chordoma. 
  • Microarray sampling-platform fabrication using bubble-jet technology for a biochip system. 
  • Mismatch repair-dependent iterative excision at irreparable O6-methylguanine lesions in human nuclear extracts. 
  • Modeling cancer progression via pathway dependencies. 
  • Modulation of circulating protein biomarkers following TRC105 (anti-endoglin antibody) treatment in patients with advanced cancer. 
  • Modulation of ligand binding affinity of the adipocyte lipid-binding protein by selective mutation. Analysis in vitro and in situ. 
  • Modulation of the unfolded protein response in prostate cancer cells by antibody-directed against the carboxyl-terminal domain of GRP78. 
  • Molecular Profiling to Determine Clonality of Serial Magnetic Resonance Imaging/Ultrasound Fusion Biopsies from Men on Active Surveillance for Low-Risk Prostate Cancer. 
  • Molecular biologic substaging of stage I NSCLC through immunohistochemistry performed on formalin-fixed, paraffin-embedded tissue. 
  • Molecular genetics of autosomal-dominant axonal Charcot-Marie-Tooth disease. 
  • Molecular interactions of B-CAM (basal-cell adhesion molecule) and laminin in epithelial skin cancer. 
  • Monoclonal antibodies for brain tumour treatment. 
  • Monoclonal antibody against human T cell leukemia virus p19 defines a human thymic epithelial antigen acquired during ontogeny. 
  • Morphologic features of 115 lymphomas of the orbit and ocular adnexa categorized according to the World Health Organization classification: are marginal zone lymphomas in the orbit mucosa-associated lymphoid tissue-type lymphomas? 
  • Multimeric complexes of the PML-retinoic acid receptor alpha fusion protein in acute promyelocytic leukemia cells and interference with retinoid and peroxisome-proliferator signaling pathways. 
  • Multiple assay characterization of murine monoclonal antimelanoma antibodies. 
  • Multiple hereditary exostoses (MHE): elucidating the pathogenesis of a rare skeletal disorder through interdisciplinary research. 
  • Multiregion ultra-deep sequencing reveals early intermixing and variable levels of intratumoral heterogeneity in colorectal cancer. 
  • Murine dendritic cells transfected with human GP100 elicit both antigen-specific CD8(+) and CD4(+) T-cell responses and are more effective than DNA vaccines at generating anti-tumor immunity. 
  • Mutation analysis in nephronophthisis using a combined approach of homozygosity mapping, CEL I endonuclease cleavage, and direct sequencing. 
  • Mutation of the PTEN tumor suppressor gene in endometrial hyperplasias. 
  • Mutations of the E-cadherin gene in human gynecologic cancers. 
  • No evidence for linkage of liability to autism to HOXA1 in a sample from the CPEA network. 
  • Novel epinephrine and cyclic AMP-mediated activation of BCAM/Lu-dependent sickle (SS) RBC adhesion. 
  • Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations. 
  • Novel therapeutic approaches to advanced prostate cancer. 
  • Oncogene pathway activation in mammary tumors dictates FDG-PET uptake. 
  • Oncogenic Abl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathway. 
  • Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23. 
  • Osteopontin regulates ubiquitin-dependent degradation of Stat1 in murine mammary epithelial tumor cells. 
  • Overexpression of the glucose-regulated stress gene GRP78 in malignant but not benign human breast lesions. 
  • Overexpression of wild-type retinoic acid receptor alpha (RARalpha) recapitulates retinoic acid-sensitive transformation of primary myeloid progenitors by acute promyelocytic leukemia RARalpha-fusion genes. 
  • PCGEM1, a prostate-specific gene, is overexpressed in prostate cancer. 
  • PSCA polymorphisms and gastric cancer susceptibility in an eastern Chinese population. 
  • PSGR, a novel prostate-specific gene with homology to a G protein-coupled receptor, is overexpressed in prostate cancer. 
  • PTEN mutation in endometrial cancers is associated with favorable clinical and pathologic characteristics. 
  • Pancreatic cyst fluid protein expression profiling for discriminating between serous cystadenoma and intraductal papillary mucinous neoplasm. 
  • Parc-ing p53 in the cytoplasm. 
  • Patterns of somatic mutation in human cancer genomes. 
  • PenPC: A two-step approach to estimate the skeletons of high-dimensional directed acyclic graphs. 
  • Pharmacokinetics and tumor localization of 131I-labeled anti-tenascin monoclonal antibody 81C6 in patients with gliomas and other intracranial malignancies. 
  • Phase 1 study in patients with metastatic melanoma of immunization with dendritic cells presenting epitopes derived from the melanoma-associated antigens MART-1 and gp100. 
  • Polymorphisms in the ERCC5 gene and risk of esophageal squamous cell carcinoma (ESCC) in Eastern Chinese populations. 
  • Polymorphisms of p16, p27, p73, and MDM2 modulate response and survival of pancreatic cancer patients treated with preoperative chemoradiation. 
  • Poorly differentiated carcinoma and poorly differentiated adenocarcinoma of unknown origin: favorable subsets of patients with unknown-primary carcinoma? 
  • Postremission therapy with low-dose interleukin 2 with or without intermediate pulse dose interleukin 2 therapy is well tolerated in elderly patients with acute myeloid leukemia: Cancer and Leukemia Group B study 9420. 
  • Potent selection of antigen loss variants of B16 melanoma following inflammatory killing of melanocytes in vivo. 
  • Precise localization of the FHIT gene to the common fragile site at 3p14.2 (FRA3B) and characterization of homozygous deletions within FRA3B that affect FHIT transcription in tumor cell lines. 
  • Prenylated c17orf37 induces filopodia formation to promote cell migration and metastasis. 
  • Prevention of brefeldin A-induced resistance to teniposide by the proteasome inhibitor MG-132: involvement of NF-kappaB activation in drug resistance. 
  • Primary mucinous carcinoma of the eyelid: a clinicopathologic and immunohistochemical study of 4 cases and an update on recurrence rates. 
  • Prognostic applications of the epidermal growth factor receptor and its ligand, transforming growth factor-alpha. 
  • Proliferative activity at colonic anastomoses as determined by statin. A nonproliferation-specific nuclear protein. 
  • Protein expression profiles in pancreatic adenocarcinoma compared with normal pancreatic tissue and tissue affected by pancreatitis as detected by two-dimensional gel electrophoresis and mass spectrometry. 
  • Proteome-Wide Characterization of Phosphorylation-Induced Conformational Changes in Breast Cancer. 
  • Proteomic analysis of calcium/calmodulin-dependent protein kinase I and IV in vitro substrates reveals distinct catalytic preferences. 
  • Proteomic analysis of stage I endometrial cancer tissue: identification of proteins associated with oxidative processes and inflammation. 
  • Proteomics in prostate cancer. 
  • Quantitation of response to therapy in patients with metastatic breast carcinoma by serial analysis of plasma gross cystic disease fluid protein and carcinoembryonic antigen. 
  • Quantitative expression profile of PSGR in prostate cancer. 
  • RAP1-mediated MEK/ERK pathway defects in Kabuki syndrome. 
  • RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation. 
  • Radioprotection of lungs by amifostine is associated with reduction in profibrogenic cytokine activity. 
  • Radiosensitization of chemotherapy-refractory, locally advanced or locally recurrent breast cancer with trastuzumab: a phase II trial. 
  • Rapid degradation of puromycyl peptides in hepatoma cells and reticulocytes. 
  • Recombinant human endostatin could eliminate the pro-angiogenesis priority of SP cells sorted from non-small cell lung cancer cells. 
  • Reduced expression of hMLH1 and hGTBP/hMSH6: a risk factor for head and neck cancer. 
  • Reduced expression of hMSH2 and hMLH1 and risk of prostate cancer: a case-control study. 
  • Reduced expression of mismatch repair genes in colorectal cancer patients in Egypt. 
  • Reduced expression of mismatch repair genes measured by multiplex reverse transcription-polymerase chain reaction in human gliomas. 
  • Regulation of survivin by ErbB2 signaling: therapeutic implications for ErbB2-overexpressing breast cancers. 
  • Regulatory network motifs and hotspots of cancer genes in a mammalian cellular signalling network. 
  • Retinoic acid receptor alpha in acute promyelocytic leukemia. 
  • Retinoic acid regulates aberrant nuclear localization of PML-RAR alpha in acute promyelocytic leukemia cells. 
  • Retroviral vectors for the transduction of the PML-RARalpha fusion product of acute promyelocytic leukemia. 
  • Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice. 
  • Role of Rap1 in promoting sickle red blood cell adhesion to laminin via BCAM/LU. 
  • Roles of Alternative RNA Splicing of the Bif-1 Gene by SRRM4 During the Development of Treatment-induced Neuroendocrine Prostate Cancer. 
  • Runx2/Cbfa1 stimulates transdifferentiation of primary skeletal myoblasts into a mineralizing osteoblastic phenotype. 
  • STT3A, C1orf24, TFF3: putative markers for characterization of follicular thyroid neoplasms from fine-needle aspirates. 
  • Sclerosing hemangioma of lung: A close cytologic mimicker of pulmonary adenocarcinoma. 
  • Selective autophagy of the adaptor protein Bcl10 modulates T cell receptor activation of NF-κB. 
  • Selective loss of RPGRIP1-dependent ciliary targeting of NPHP4, RPGR and SDCCAG8 underlies the degeneration of photoreceptor neurons. 
  • Sequential delivery of maturation stimuli increases human dendritic cell IL-12 production and enhances tumor antigen-specific immunogenicity. 
  • Sequential phase II Southwest Oncology Group studies (S0112 and S0301) of daunorubicin and cytarabine by continuous infusion, without and with ciclosporin, in older patients with previously untreated acute myeloid leukaemia. 
  • Serum melanotransferrin, p97 as a biochemical marker of Alzheimer's disease. 
  • Serum protein expression predicts recurrence in patients with early-stage lung cancer after resection. 
  • Short-term kinetics of tumor antigen expression in response to vaccination. 
  • Side population cells in human cancers. 
  • Simultaneous detection of the tumor suppressor FHIT gene and protein using the multi-functional biochip. 
  • Small Cell Lung Cancer Exhibits Frequent Inactivating Mutations in the Histone Methyltransferase KMT2D/MLL2: CALGB 151111 (Alliance). 
  • So-called massive retinal gliosis: A critical review and reappraisal. 
  • Soluble factor in normal tissues that stimulates high-molecular-weight sialoglycoprotein production by human colon carcinoma cells. 
  • Speckled-like pattern in the germinal center (SLIP-GC), a nuclear GTPase expressed in activation-induced deaminase-expressing lymphomas and germinal center B cells. 
  • Stage-specific expression of B cell translocation gene 1 in rat testis. 
  • Status of activation of circulating vaccine-elicited CD8+ T cells. 
  • Stemming Lung Disease? 
  • Structural requirements for high affinity ligand binding by estrogen receptors: a comparative analysis of truncated and full length estrogen receptors expressed in bacteria, yeast, and mammalian cells. 
  • Subungual leiomyoma in the left thumb of a 16-year-old female. 
  • Superantigen enhanced protection against a weak tumor-specific melanoma antigen: implications for prophylactic vaccination against cancer. 
  • Suppressor and activator functions mediated by a repeated heptad sequence in the liver fatty acid-binding protein gene (Fabpl). Effects on renal, small intestinal, and colonic epithelial cell gene expression in transgenic mice. 
  • Surface proteins of a transitional carcinoma cell line (KS-31E). 
  • Survival analysis of presumptive prognostic markers among oligodendrogliomas. 
  • Survivin DNA vaccine generated specific antitumor effects in pancreatic carcinoma and lymphoma mouse models. 
  • Synergistic effects of multiple natural products in pancreatic cancer cells. 
  • Synergy between tumor immunotherapy and antiangiogenic therapy. 
  • Systematic identification of signaling pathways with potential to confer anticancer drug resistance. 
  • Systemic inflammatory response syndrome after human syngeneic intestinal transplantation: evidence for disruption of enterocyte barrier function. 
  • Systemic surfaceome profiling identifies target antigens for immune-based therapy in subtypes of advanced prostate cancer. 
  • T cell receptor-dependent activation of mTOR signaling in T cells is mediated by Carma1 and MALT1, but not Bcl10. 
  • Targeted resequencing and systematic in vivo functional testing identifies rare variants in MEIS1 as significant contributors to restless legs syndrome. 
  • Targeting Id1 and Id3 inhibits peritoneal metastasis of gastric cancer. 
  • Targeting the Wnt-Regulatory Protein CTNNBIP1 by microRNA-214 Enhances the Stemness and Self-Renewal of Cancer Stem-Like Cells in Lung Adenocarcinomas. 
  • Targeting the local tumor microenvironment with vaccinia virus expressing B7.1 for the treatment of melanoma. 
  • Telomerase activity in normal leukocytes and in hematologic malignancies. 
  • Template for reporting results of biomarker testing of specimens from patients with carcinoma of the colon and rectum. 
  • Tenascin: an extracellular matrix protein prominent in specialized embryonic tissues and tumors. 
  • The Abl family kinases: mechanisms of regulation and signaling. 
  • The CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8) ubiquitin ligase promotes degradation of hematopoietic progenitor kinase 1. 
  • The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency. 
  • The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer. 
  • The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR. 
  • The Role of Biliary Carcinoembryonic Antigen-Related Cellular Adhesion Molecule 6 (CEACAM6) as a Biomarker in Cholangiocarcinoma. 
  • The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours. 
  • The acute promyelocytic leukaemia-associated PML gene is induced by interferon. 
  • The acute promyelocytic leukemia PML-RAR alpha protein induces hepatic preneoplastic and neoplastic lesions in transgenic mice. 
  • The antiapoptotic protein Mcl-1 is essential for the survival of neutrophils but not macrophages. 
  • The detection of telomerase activity in patients with adenocarcinoma of the pancreas by fine needle aspiration. 
  • The effect of protein nutrition on host and tumor metabolism. 
  • The elongation domain of ELL is dispensable but its ELL-associated factor 1 interaction domain is essential for MLL-ELL-induced leukemogenesis. 
  • The genetic attributable risk of breast and ovarian cancer. 
  • The genetic landscape of mutations in Burkitt lymphoma. 
  • The genetic landscape of the childhood cancer medulloblastoma. 
  • The genomic landscape of mantle cell lymphoma is related to the epigenetically determined chromatin state of normal B cells. 
  • The glucocorticoid receptor interacting protein 1 (GRIP1) localizes in discrete nuclear foci that associate with ND10 bodies and are enriched in components of the 26S proteasome. 
  • The oncogenic capacity of HRX-ENL requires the transcriptional transactivation activity of ENL and the DNA binding motifs of HRX. 
  • The role of Ctr1 and Ctr2 in mammalian copper homeostasis and platinum-based chemotherapy. 
  • The role of MTJ-1 in cell surface translocation of GRP78, a receptor for alpha 2-macroglobulin-dependent signaling. 
  • The role of N-acetylation polymorphisms in smoking-associated bladder cancer: evidence of a gene-gene-exposure three-way interaction. 
  • The role of hPMS1 and hPMS2 in predisposing to colorectal cancer. 
  • The role of protein phosphorylation in therapy resistance and disease progression in chronic myelogenous leukemia. 
  • The t(15;17) translocation in acute promyelocytic leukemia. 
  • The t(15;17) translocation in acute promyelocytic leukemia. 
  • The therapeutic effects of SET/I2PP2A inhibitors on canine melanoma. 
  • The treatment of colorectal carcinoma: standard chemotherapy and beyond. 
  • The tumor biology of melanoma nodal metastases. 
  • Threshold levels of gene expression of the melanoma antigen gp100 correlate with tumor cell recognition by cytotoxic T lymphocytes. 
  • Topotecan, a topoisomerase I inhibitor, is active in the treatment of myelodysplastic syndrome and chronic myelomonocytic leukemia. 
  • Transfection of RNA encoding tumor antigens following maturation of dendritic cells leads to prolonged presentation of antigen and the generation of high-affinity tumor-reactive cytotoxic T lymphocytes. 
  • Transforming growth factor-beta differentially inhibits epithelial ovarian carcinoma cells from primary and metastatic isolates without up-regulation of p21WAF1. 
  • Transport rather than diffusion-dependent route for nitric oxide gas activity in alveolar epithelium. 
  • Treatment of intracranial human glioma xenografts with 131I-labeled anti-tenascin monoclonal antibody 81C6. 
  • Trophinin is a potent prognostic marker of ovarian cancer involved in platinum sensitivity. 
  • Tumor marker expression is predictive of survival in patients with esophageal cancer. 
  • Two serologic markers to monitor the engraftment, growth, and treatment response of human leukemias in severe combined immunodeficient mice. 
  • Unique proteins defined by monoclonal antibodies specific for human melanoma. Some potential clinical applications. 
  • Unusual superficial variant of granular corneal dystrophy with amyloid deposition. 
  • Utility of a molecular prescreening program in advanced colorectal cancer for enrollment on biomarker-selected clinical trials. 
  • Utility of immunohistochemistry in predicting microsatellite instability in endometrial carcinoma. 
  • Utilizing quantitative polymerase chain reaction to evaluate prostate stem cell antigen as a tumor marker in pancreatic cancer. 
  • Variability in platelet procoagulant activity in healthy volunteers. 
  • Whole Genomic Copy Number Alterations in Circulating Tumor Cells from Men with Abiraterone or Enzalutamide-Resistant Metastatic Castration-Resistant Prostate Cancer. 
  • Whole-exome sequencing studies of parathyroid carcinomas reveal novel PRUNE2 mutations, distinctive mutational spectra related to APOBEC-catalyzed DNA mutagenesis and mutational enrichment in kinases associated with cell migration and invasion. 
  • XPD/ERCC2 EXON 8 Polymorphisms: rarity and lack of significance in risk of squamous cell carcinoma of the head and neck. 
  • [Chicken RNA tumor viruses: a model for virus-induced carcinogenesis] 
  • c-Jun promotes whereas JunB inhibits epidermal neoplasia. 
  • c-Myb and core-binding factor/PEBP2 display functional synergy but bind independently to adjacent sites in the T-cell receptor delta enhancer. 
  • miR-203, a tumor suppressor frequently down-regulated by promoter hypermethylation in rhabdomyosarcoma. 
  • p53 and MDM2 immunostaining in pulmonary blastomas and bronchogenic carcinomas. 
  • p53 and mdm-2 expression in malignant melanoma: an immunocytochemical study of expression of p53, mdm-2, and markers of cell proliferation in primary versus metastatic tumors. 
  • p53-dependent induction of heat shock protein 27 (HSP27) expression. 
  • β-Arrestin2 mediates the initiation and progression of myeloid leukemia. 
• 

  Keywords of People

  • Abbruzzese, James, D. C. I. Professor of Medical Oncology, Medicine, Medical Oncology
  • Berchuck, Andrew, James M. Ingram Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Cianciolo, George James, Associate Professor in Pathology, Pathology
  • Ciofani, Maria, Assistant Professor of Immunology, Immunology
  • Erickson, Harold Paul, James B. Duke Professor of Cell Biology, Biomedical Engineering
  • Ferreira, Paulo Alexandre, Associate Professor in Ophthalmology, Pathology
  • Hilton, Matthew James, Associate Professor in Orthopaedic Surgery, Cell Biology
  • Hogan, Brigid L. M., George Barth Geller Professor, Cell Biology
  • Krangel, Michael S., Mary Bernheim Professor of Immunology, Immunology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Meyer, Joel, Truman and Nellie Semans/Alex Brown and Sons Associate Professor of Molecular Environmental Toxicology, Duke University Energy Initiative
  • Moorman, Patricia Gripka, Professor in Community and Family Medicine, Duke Cancer Institute
  • Sullivan, Daniel Carl, Professor Emeritus of Radiology, Radiology
  • Thompson, Eric Michael, Associate Professor of Neurosurgery, Pathology
  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Professor of Experimental Surgery, in the School of Medicine, Immunology
  • Woodward, Julie Ann, Professor of Ophthalmology, Dermatology
  • Zafar, Syed Yousuf, Associate Professor of Medicine, Medicine, Medical Oncology
  • Zhong, Xiaoping, Professor of Pediatrics, Immunology