Neoplasms, Experimental

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  Subject Areas on Research

  • A comparison of antiangiogenic therapies for the prevention of liver metastases. 
  • A comparison of the structure of hamster pancreatic insulin and insulin extracted from a transplantable hamster islet-cell carcinoma. 
  • A comprehensive method for optical-emission computed tomography. 
  • A new synthetic protectin D1 analog 3-oxa-PD1n-3 DPA reduces neuropathic pain and chronic itch in mice. 
  • A new temperature-sensitive liposome for use with mild hyperthermia: characterization and testing in a human tumor xenograft model. 
  • A novel mechanism of skin tumor promotion involving interferon-gamma (IFNγ)/signal transducer and activator of transcription-1 (Stat1) signaling. 
  • A single genetic locus determines the efficacy of serum therapy against murine adenocarcinoma 755a. 
  • ACTH receptors in the adrenal: specific binding of ACTH-125I and its relation to adenyl cyclase. 
  • AMPK Alpha-1 Intrinsically Regulates the Function and Differentiation of Tumor Myeloid-Derived Suppressor Cells. 
  • ATM inhibition enhances cancer immunotherapy by promoting mtDNA leakage and cGAS/STING activation. 
  • Activation of cyclophosphamide for in vitro testing of cell sensitivity. 
  • Active immunization with tumor cells transduced by a novel AAV plasmid-based gene delivery system. 
  • Activity of VNP40101M (Cloretazine) in the treatment of CNS tumor xenografts in athymic mice. 
  • Adenocarcinoma of the kidney. II. Enzyme histochemistry of renal adenocarcinomas induced in rats by N-(4'-fluoro-4-biphenylyl)acetamide. 
  • Allotransplantation of insulinoma into the testis of diabetic rats. 
  • An analysis of the uncertainty and bias in DCE-MRI measurements using the spoiled gradient-recalled echo pulse sequence. 
  • An improved method of preparing Schmidt-Ruppin Rous sarcoma virus for brain tumor induction in mammals. 
  • An inhibitor of macrophage chemotaxis produced by neoplasms. 
  • Anaplastic human gliomas grown in athymic mice. Morphology and glial fibrillary acidic protein expression. 
  • Androgen receptor splice variant AR3 promotes prostate cancer via modulating expression of autocrine/paracrine factors. 
  • Animal modeling and thermal dose. 
  • Anti-tumor immunotherapy despite immunity to adenovirus using a novel adenoviral vector Ad5 [E1-, E2b-]-CEA. 
  • Antigen-loaded monocyte administration induces potent therapeutic antitumor T cell responses. 
  • Application of optical imaging and spectroscopy to radiation biology. 
  • Architectural pattern, tissue and cellular morphology in livers of fishes: relationship to experimentally-induced neoplastic responses. 
  • Arteriolar oxygenation in tumour and subcutaneous arterioles: effects of inspired air oxygen content. 
  • Assessment of myeloma maintenance regimen of prednisone. Adriamycin, imuran, and vincristine in a murine plasmacytoma model. 
  • Astatine-211 labeling of internalizing anti-EGFRvIII monoclonal antibody using N-succinimidyl 5-[211At]astato-3-pyridinecarboxylate. 
  • Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor. 
  • Biochemical correlates of temozolomide sensitivity in pediatric solid tumor xenograft models. 
  • Biology of gliomas: potential clinical implications of glioma cellular heterogeneity. 
  • Boosting high-intensity focused ultrasound-induced anti-tumor immunity using a sparse-scan strategy that can more effectively promote dendritic cell maturation. 
  • Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines. 
  • Brain tumor types induced by the Schmidt-Ruppin strain of Rous sarcoma virus in inbred Fischer rats. 
  • Brain tumors in man and animals: report of a workshop. 
  • Bromodeoxyuridine-mediated radiosensitization in human glioma: the effect of concentration, duration, and fluoropyrimidine modulation. 
  • C-type virus particles in human urogenital tumours after heterotransplantation into nude mice. 
  • Cancer-Associated Fibroblasts Induce a Collagen Cross-link Switch in Tumor Stroma. 
  • Capillary isoelectric-focusing immunoassays to study dynamic oncoprotein phosphorylation and drug response to targeted therapies in non-small cell lung cancer. 
  • Cardiovascular and metabolic response of tumour-bearing dogs to whole body hyperthermia. 
  • Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy. 
  • Caspase-2 impacts lung tumorigenesis and chemotherapy response in vivo. 
  • Caspase-3 promotes genetic instability and carcinogenesis. 
  • Cell-based vaccines for the stimulation of immunity to metastatic cancers. 
  • Cell-enhanced dissolution of carcinogenic lead chromate particles: the role of individual dissolution products in clastogenesis. 
  • Cellular immunity in rats with primary brain tumors: inhibition of macrophage migration by soluble extracts of avian sarcoma virus-induced tumors. 
  • Cellular redox modulator, ortho Mn(III) meso-tetrakis(N-n-hexylpyridinium-2-yl)porphyrin, MnTnHex-2-PyP(5+) in the treatment of brain tumors. 
  • Changes in the behaviour of teratocarcinoma cells cultivated in vitro. 
  • Characterization of a human prostate adenocarcinoma cell line (DU 145) as a monolayer culture and as a solid tumor in athymic mice. 
  • Characterization of the effects of endotoxin on macrophage tumor cell killing. 
  • Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression. 
  • Chemotherapy and radiation therapy of human medulloblastoma in athymic nude mice. 
  • Clinical application of thermal isoeffect dose. 
  • Combination testing (Stage 2) of the Anti-IGF-1 receptor antibody IMC-A12 with rapamycin by the pediatric preclinical testing program. 
  • Combination treatment of murine tumors by adenovirus-mediated local B7/IL12 immunotherapy and radiotherapy. 
  • Comparative permeability of different glioma models to horseradish peroxidase. 
  • Comparison of animal models for head and neck cancer cachexia. 
  • Comparison of monoamine oxidase in golden hamster islets and insulinoma. 
  • Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition. 
  • Computed tomography of virally induced canine brain tumors: a preliminary report. 
  • Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF(V600E) colorectal cancer. 
  • Creatine and phosphocreatine analogs: anticancer activity and enzymatic analysis. 
  • Cross-reacting antigens on L5178Y cells which serve as targets for cytotoxic T-lymphocyte lysis during establishment of the tumor dormant state. 
  • Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors 
  • Cyclocreatine (1-carboxymethyl-2-iminoimidazolidine) inhibits growth of a broad spectrum of cancer cells derived from solid tumors. 
  • Cyclooxygenase-2 is a novel transcriptional target of the nuclear EGFR-STAT3 and EGFRvIII-STAT3 signaling axes. 
  • DNA repair: a double-edged sword. 
  • Decreased fibronectin expression in Met/HGF-mediated tumorigenesis. 
  • Detection of metastatic tumors in nude mice: brief communication. 
  • Development and application of basic research techniques in bladder cancer research. 
  • Dihydrofolate reductase in primary brain tumors, cell cultures of central nervous system origin, and normal brain during fetal and neonatal growth. 
  • Dissecting the roles of E1A and E1B in adenoviral replication and RCAd-enhanced RDAd transduction efficacy on tumor cells. 
  • Distinguishing effects on tumor multiplicity and growth rate in chemoprevention experiments. 
  • Dominant-negative androgen receptor inhibition of intracrine androgen-dependent growth of castration-recurrent prostate cancer. 
  • Doxorubicin-conjugated polypeptide nanoparticles inhibit metastasis in two murine models of carcinoma. 
  • Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents. 
  • EGFRvIII-targeted immunotoxin induces antitumor immunity that is inhibited in the absence of CD4+ and CD8+ T cells. 
  • Ectopic beta-adrenergic receptor binding sites. possible molecular basis of aberrant catecholamine responsiveness of an adrenocortical tumor adenylate cyclase. 
  • Effect of 5-hydroxytryptamine on tissue blood flow and microwave heating of rat tumors. 
  • Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. 
  • Effect of Uveal Melanocytes on Choroidal Morphology in Rhesus Macaques and Humans on Enhanced-Depth Imaging Optical Coherence Tomography. 
  • Effect of adriamycin and Corynebacterium parvum in tumor-bearing mice: modulation of response to sheep red blood cells. 
  • Effect of aerobic exercise on tumor physiology in an animal model of human breast cancer. 
  • Effect of drug release kinetics on nanoparticle therapeutic efficacy and toxicity. 
  • Effect of hormones on the growth of virus-transformed hamster prostatic tissue. 
  • Effect of neuronol on lifespan and development of spontaneous tumors in SAMP-1 mice with genetically accelerated aging. 
  • Effect of synthetic thymic and pineal peptides on biomarkers of ageing, survival and spontaneous tumour incidence in female CBA mice. 
  • Effective treatment of experimental DU-145 prostate cancers with targeted cytotoxic somatostatin analog AN-238. 
  • Effects of CKS-17, a synthetic retroviral envelope peptide, on cell-mediated immunity in vivo: immunosuppression, immunogenicity, and relation to immunosuppressive tumor products. 
  • Effects of adrenal cortical steroids and osmotic blood-brain barrier opening on methotrexate delivery to gliomas in the rodent: the factor of the blood-brain barrier. 
  • Effects of antifungal agents and gamma interferon on macrophage cytotoxicity for fungi and tumor cells. 
  • Effects of calcium on ACTH stimulation of the adrenal: separation of hormone binding from adenyl cyclase activation. 
  • Effects of high-dose microbeam irradiation on tumor microvascular function and angiogenesis. 
  • Effects of murine cytomegalovirus infection on the immune response to a tumor allograft. 
  • Effects of oxygen on the metabolism of murine tumors using in vivo phosphorus-31 NMR. 
  • Effects of pentobarbital anesthesia on the energy metabolism of murine tumors studied by in vivo 31P nuclear magnetic resonance spectroscopy. 
  • Effects of tumor growth on host defenses. 
  • Efficacy of liposomes and hyperthermia in a human tumor xenograft model: importance of triggered drug release. 
  • Efficacy of topoisomerase I inhibitors, topotecan and irinotecan, administered at low dose levels in protracted schedules to mice bearing xenografts of human tumors. 
  • Endogenous expression of transforming growth factor beta1 inhibits growth and tumorigenicity and enhances Fas-mediated apoptosis in a murine high-grade glioma model. 
  • Endoglin interacts with VEGFR2 to promote angiogenesis. 
  • Enhanced tumor localization and in vivo stability of a monoclonal antibody radioiodinated using N-succinimidyl 3-(tri-n-butylstannyl)benzoate. 
  • Epidermal growth factor receptor as a novel molecular target for aggressive papillary tumors in the middle ear and temporal bone. 
  • Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition. 
  • Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth. 
  • Estimation of cell survival in tumours heated to nonuniform temperature distributions. 
  • Evaluation of the lipid-soluble diaminopyrimidines, metoprine and etoprine, in the avian sarcoma virus rat glioma model. 
  • Exercise modulation of the host-tumor interaction in an orthotopic model of murine prostate cancer. 
  • Factors controlling oxygen utilization. 
  • Factors influencing the cell type of brain tumors induced in dogs by Schmidt-Ruppin Rous sarcoma virus. 
  • Failure of monoclonal antibodies against tumor associated antigens to improve tumor targeting of LAK cells in a model of rat colon carcinoma. 
  • Fibrous glass and cancer. 
  • Folate-targeted pH-responsive calcium zoledronate nanoscale metal-organic frameworks: Turning a bone antiresorptive agent into an anticancer therapeutic. 
  • From embryo to teratocarcinoma in tissue culture. 
  • GRP94 (gp96) and GRP94 N-terminal geldanamycin binding domain elicit tissue nonrestricted tumor suppression. 
  • General immunocompetence of rats bearing avian sarcoma virus-induced intracranial tumors. 
  • Generation of anti-idiotypic reagents in the EGFRvIII tumor-associated antigen system. 
  • Genetic and epigenetic inactivation of Kruppel-like factor 4 in medulloblastoma. 
  • Genetic induction of tumorigenesis in swine. 
  • Glial fibrillary acidic protein synthesized in vitro using messenger RNA from a human glioma cell line. 
  • Glial-mesenchymal tropism of in vivo avian sarcoma virus neuro-oncogenesis in rats. 
  • Grey matter edema: the marginal zone of autochthonous virally-induced gliomas. 
  • Growth and chemotherapeutic response in athymic mice of tumors arising from human glioma-derived cell lines. 
  • H1 histone and nucleosome repeat length alterations associated with the in vitro differentiation of murine embryonal carcinoma cells to extra-embryonic endoderm. 
  • Helix-loop-helix transcription factors E12 and E47 are not essential for skeletal or cardiac myogenesis, erythropoiesis, chondrogenesis, or neurogenesis. 
  • Heterogeneity of Genotypic and phenotypic characteristics of fifteen permanent cell lines derived from human gliomas. 
  • Heterotransplantation of a human prostatic adenocarcinoma cell line in nude mice. 
  • High intensity focused ultrasound-induced gene activation in solid tumors. 
  • High molecular weight extracellular proteins synthesized by endoderm cells derived from mouse teratocarcinoma cells and normal extraembryonic membranes. 
  • Human melanoma growth in the peritoneal cavity of the athymic mouse--a model for in vivo study of cell-mediated immunity. 
  • Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma. 
  • Humoral antibody response and tumor transplantation resistance elicited by fetal tissues in mice. 
  • Hyperbaric oxygen improves tumor radiation response significantly more than carbogen/nicotinamide. 
  • Hyperimmunization of non-human primates with BCG-CW and cultured human glioma-derived cells. Production of reactive antisera and absence of EAE induction. 
  • Hypothesis: when is a seminoma not a seminoma? 
  • IL15 Agonists Overcome the Immunosuppressive Effects of MEK Inhibitors. 
  • Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts. 
  • Immune (gamma) interferon production by a murine T cell lymphoma: requirements for macromolecular synthesis and lack of relationship with cell cycle. 
  • Immunodiagnosis of tumors in vivo using radiolabeled monoclonal antibody A2B5. 
  • Impact of synchronized anti-PD-1 with Ad-CEA vaccination on inhibition of colon cancer growth. 
  • In situ growth of a PEG-like polymer from the C terminus of an intein fusion protein improves pharmacokinetics and tumor accumulation. 
  • In situ nuclear morphology measurements using light scattering as biomarkers of neoplastic change in animal models of carcinogenesis. 
  • In vivo antigenic modification of tumor cells. III. Metastatic thymic lymphoma specifically infected by thymotropic retrovirus. 
  • In vivo evaluation of cell mediated immunity against human melanoma. 
  • In vivo expansion, persistence, and function of peptide vaccine-induced CD8 T cells occur independently of CD4 T cells. 
  • In vivo modulation of macrophage tumoricidal activity: enhanced tumor cell killing by peritoneal macrophages from mice given injections of sodium periodate. 
  • In vivo tumor localization using tumor-specific monkey xenoantibody, alloantibody, and murine monoclonal xenoantibody. 
  • Induced sensitization of tumor stroma leads to eradication of established cancer by T cells. 
  • Induction of cytotoxic T cell responses and tumor immunity against unrelated tumors using telomerase reverse transcriptase RNA transfected dendritic cells. 
  • Influence of age at inoculation on avian oncornavirus-induced brain tumor incidence, tumor morphology, and postinoculation survival in F344 rats. 
  • Influence of mouse hepatitis virus on the growth of human melanoma in the peritoneal cavity of the athymic mouse. 
  • Inhibition of Pten deficient Castration Resistant Prostate Cancer by Targeting of the SET - PP2A Signaling axis. 
  • Inhibition of invariant chain expression in dendritic cells presenting endogenous antigens stimulates CD4+ T-cell responses and tumor immunity. 
  • Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. 
  • Inhibition of tumor growth by targeting tumor endothelium using a soluble vascular endothelial growth factor receptor. 
  • Initial testing (Stage 1) of the antibody-maytansinoid conjugate, IMGN901 (Lorvotuzumab mertansine), by the pediatric preclinical testing program. 
  • Initial testing (stage 1) of eribulin, a novel tubulin binding agent, by the pediatric preclinical testing program. 
  • Initial testing (stage 1) of ganetespib, an Hsp90 inhibitor, by the Pediatric Preclinical Testing Program. 
  • Initial testing (stage 1) of sunitinib by the pediatric preclinical testing program. 
  • Initial testing (stage 1) of the Polo-like kinase inhibitor volasertib (BI 6727), by the Pediatric Preclinical Testing Program. 
  • Initial testing (stage 1) of the curaxin CBL0137 by the pediatric preclinical testing program. 
  • Initial testing (stage 1) of the cyclin dependent kinase inhibitor SCH 727965 (dinaciclib) by the pediatric preclinical testing program. 
  • Initial testing (stage 1) of the histone deacetylase inhibitor, quisinostat (JNJ-26481585), by the Pediatric Preclinical Testing Program. 
  • Initial testing (stage 1) of the investigational mTOR kinase inhibitor MLN0128 by the pediatric preclinical testing program. 
  • Initial testing (stage 1) of the mTOR inhibitor rapamycin by the pediatric preclinical testing program. 
  • Initial testing (stage 1) of the mTOR kinase inhibitor AZD8055 by the pediatric preclinical testing program. 
  • Initial testing (stage 1) of the notch inhibitor PF-03084014, by the pediatric preclinical testing program. 
  • Initial testing of VS-4718, a novel inhibitor of focal adhesion kinase (FAK), against pediatric tumor models by the Pediatric Preclinical Testing Program. 
  • Initial testing of a monoclonal antibody (IMC-A12) against IGF-1R by the Pediatric Preclinical Testing Program. 
  • Initial testing of lenalidomide by the pediatric preclinical testing program. 
  • Initial testing of the CENP-E inhibitor GSK923295A by the pediatric preclinical testing program. 
  • Initial testing of the VEGFR inhibitor AZD2171 by the pediatric preclinical testing program. 
  • Initial testing of the aurora kinase A inhibitor MLN8237 by the Pediatric Preclinical Testing Program (PPTP). 
  • Initial testing of the replication competent Seneca Valley virus (NTX-010) by the pediatric preclinical testing program. 
  • Instant Ultrasound-Evoked Precise Nanobubble Explosion and Deep Photodynamic Therapy for Tumors Guided by Molecular Imaging. 
  • Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation. 
  • Intranasal immunization with CTL epitope peptides from HIV-1 or ovalbumin and the mucosal adjuvant cholera toxin induces peptide-specific CTLs and protection against tumor development in vivo. 
  • Intranasal mRNA nanoparticle vaccination induces prophylactic and therapeutic anti-tumor immunity. 
  • Is hyperbaric oxygen more effective than carbogen/nicotinamide in tumor radiation response? 
  • Isoform-Specific Effects of Wild-Type Ras Genes on Carcinogen-Induced Lung Tumorigenesis in Mice. 
  • Isolation of a transplantable cell line induced by the MC29 avian leukosis virus. 
  • Ligand-independent toll-like receptor signals generated by ectopic overexpression of MyD88 generate local and systemic antitumor immunity. 
  • Local hyperthermia improves uptake of a chimeric monoclonal antibody in a subcutaneous xenograft model. 
  • Localisation of [131I]MIBG in nude mice bearing SK-N-SH human neuroblastoma xenografts: effect of specific activity. 
  • Longitudinal optical imaging of tumor metabolism and hemodynamics. 
  • Lymphocyte subpopulations and responsiveness in rats bearing intracranial tumors induced by avian sarcoma virus. 
  • Macrophage tumor killing: influence of the local environment. 
  • Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: intravital microscopy and measurement of vascular permeability. 
  • Method for improved accuracy in endogenous urea recovery marker calibrations for microdialysis in tumors. 
  • Microarray sampling-platform fabrication using bubble-jet technology for a biochip system. 
  • Microglia are effector cells of CD47-SIRPα antiphagocytic axis disruption against glioblastoma. 
  • Microvascular abnormalities in virally-induced canine brain tumors. Structural bases for altered blood-brain barrier function. 
  • Microwave treatment of intracerebral L1210 leukemia: schedule-dependent partial reversal of the effects of methotrexate. 
  • Modeling tumor onset and multiplicity using transition models with latent variables. 
  • Modulation of the tumoricidal function of activated macrophages by bacterial endotoxin and mammalian macrophage activation factor (s). 
  • Monoamine oxidase and catechol-O-methyltransferase activity in hamster and rat insulinomas. 
  • Monocyte chemotactic mechanisms in patients with hypernephroma. 
  • Morphologic observations of brain tumors in PD4 hamsters induced by four strains of avian sarcoma virus. 
  • Morphological and biochemical studies of virus (SV40) transformed prostatic tissue. 
  • Morphological and neoplastic transformation of C3H/10T1/2 Cl 8 mouse embryo cells by insoluble carcinogenic nickel compounds. 
  • Murine dendritic cells transfected with human GP100 elicit both antigen-specific CD8(+) and CD4(+) T-cell responses and are more effective than DNA vaccines at generating anti-tumor immunity. 
  • Murine in vitro antigenic modification of tumor cells: effect on susceptibility to natural cell-mediated cytotoxicity. 
  • Muscle mTORC1 suppression by IL-6 during cancer cachexia: a role for AMPK. 
  • Mutational landscape in genetically engineered, carcinogen-induced, and radiation-induced mouse sarcoma. 
  • Near-infrared optical imaging of integrin alphavbeta3 in human tumor xenografts. 
  • Near-infrared resonant nanoshells for combined optical imaging and photothermal cancer therapy. 
  • Non-invasive monitoring of intra-tumor drug concentration and therapeutic response using optical spectroscopy. 
  • Non-specific and specific active immunotherapy in a B16 murine melanoma system. 
  • Noninvasive visualization of tumors in rodent dorsal skin window chambers. 
  • Nonlinear dependence of hydraulic conductivity on tissue deformation during intratumoral infusion. 
  • Nordihydroguaiaretic acid (NDGA) inhibits the IGF-1 and c-erbB2/HER2/neu receptors and suppresses growth in breast cancer cells. 
  • Novikoff hepatoma deoxyribonucleic acid polymerase. Sensitivity of the beta-polymerase to sulfhydryl blocking agents. 
  • Nuclear morphology measurements with angle-resolved low coherence interferometry for application to cell biology and early cancer detection. 
  • Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis. 
  • Oncogenic and immunogenic potential of cloned HIX virus in mice and cats. 
  • Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants. 
  • Osteopontin increases CD44 expression and cell adhesion in RAW 264.7 murine leukemia cells. 
  • Overcoming limitations in nanoparticle drug delivery: triggered, intravascular release to improve drug penetration into tumors. 
  • Overview of genetically engineered mouse models of colorectal carcinoma to enable translational biology and drug development. 
  • Oxygen regulation of tumor perfusion by S-nitrosohemoglobin reveals a pressor activity of nitric oxide. 
  • Permeability of different experimental brain tumor models to horseradish peroxidase. 
  • Peroxide detoxification affecting the production of immunoglobulin by mouse myeloma tumor cells in vitro. 
  • Pharmacodynamic and genomic markers associated with response to the XPO1/CRM1 inhibitor selinexor (KPT-330): A report from the pediatric preclinical testing program. 
  • Plasmonic gold nanostar-mediated photothermal immunotherapy for brain tumor ablation and immunologic memory. 
  • Preoperative stimulation of resolution and inflammation blockade eradicates micrometastases. 
  • Prevention of glioma induction in rats by simultaneous intracerebral inoculation of avian sarcoma virus plus bacillus Calmette-Guerin cell-wall preparation. 
  • Production of extracellular proteolytic enzymes by neoplastic and normal epithelial cells. 
  • Proliferation behavior of E. coli in a three-dimensional in vitro tumor model. 
  • Protective immunosurveillance and therapeutic antitumor activity of gammadelta T cells demonstrated in a mouse model of prostate cancer. 
  • Quantification of longitudinal tissue pO2 gradients in window chamber tumours: impact on tumour hypoxia. 
  • Quantitative analysis of intratumoral infusion of color molecules. 
  • Quantitative, noninvasive imaging of radiation-induced DNA double-strand breaks in vivo. 
  • Re-evaluating the role of heat-shock protein-peptide interactions in tumour immunity. 
  • Red blood cell polyamine levels and host toxicity during continuous alpha-difluoromethylornithine infusion. 
  • Regional measurements of blood flow in experimental RG-2 rat gliomas. 
  • Regional measurements of blood-to-tissue transport in experimental RG-2 rat gliomas. 
  • Regression of tumors in mice vaccinated with professional antigen-presenting cells pulsed with tumor extracts. 
  • Regulation of cell division and of tyrosinase in B16 melanoma cells by imidazole: a possible role for the concept of metabolite gene regulation in mammalian cells. 
  • Regulation of protein kinase C and role in cancer biology. 
  • Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. 
  • Relationship of erythrocyte polyamine levels and growth rate of transplantable tumors in rats. 
  • Relationship of in vitro morphologic and growth characteristics of established human glioma-derived cell lines to their tumorigenicity in athymic nude mice. 
  • Relaxin treatment of solid tumors: effects on electric field-mediated gene delivery. 
  • Renal tubular carcinoma; animal model: chemically induced renal tubular carcinoma in rats. 
  • Resistance of neoplasms to immunological destruction: role of a macrophage chemotaxis inhibitor. 
  • Restriction of tumor growth in mice by sodium-deficient diet. 
  • Ribosomal subunits of Landschütz ascites cells during changes in polysome distribution. 
  • Role of dietary sphingolipids and inhibitors of sphingolipid metabolism in cancer and other diseases. 
  • SOX2 expression is an early event in a murine model of EGFR mutant lung cancer and promotes proliferation of a subset of EGFR mutant lung adenocarcinoma cell lines. 
  • STAT1-induced ASPP2 transcription identifies a link between neuroinflammation, cell polarity, and tumor suppression. 
  • STAT3-enhancing germline mutations contribute to tumor-extrinsic immune evasion. 
  • SV40-transformed hamster prostatic tissue: a model of human prostatic malignancy. 
  • Sequence complexity of nuclear and cytoplasmic ribonucleic acids from clonal neurotumor cell lines and brain sections of the rat. 
  • Sequential adsorption analysis of antibodies to neuroectodermal cells by an indirect quantitative method. 
  • Serine substitution of proline at codon 151 of TP53 confers gain of function activity leading to anoikis resistance and tumor progression of head and neck cancer cells. 
  • Serum amyloid A as a tumor marker in sera of nude mice with orthotopic human pancreatic cancer and in plasma of patients with pancreatic cancer. 
  • Short chain fatty acids increase prolactin and growth hormone production and alter cell morphology in the GH3 strain of rat pituitary cells. 
  • Sickle erythrocytes target cytotoxics to hypoxic tumor microvessels and potentiate a tumoricidal response. 
  • Simple and sensitive assay employing stable reagents for quantification of plasminogen activator. 
  • Simultaneous administration of glucose and hyperoxic gas achieves greater improvement in tumor oxygenation than hyperoxic gas alone. 
  • Solubilization and partial isolation of human melanoma tumor-associated antigens. 
  • Some structural aspects of dog brain tumors induced with the Schmidt-Ruppin strain of the Rous sarcoma virus. 
  • Spatial distribution of proliferating cells in avian sarcoma virus-induced gliomas. 
  • Spatiotemporal Tracking of Brain-Tumor-Associated Myeloid Cells in Vivo through Optical Coherence Tomography with Plasmonic Labeling and Speckle Modulation. 
  • Spatiotemporally photoradiation-controlled intratumoral depot for combination of brachytherapy and photodynamic therapy for solid tumor. 
  • Specificity, cross-reactivity, and affinity of 125I-labeled antiglioma antibodies for monolayers of cultured glioma cells. 
  • Spontaneous metastasis of cells of the human prostate carcinoma cell line PC-3 in athymic nude mice. 
  • Stage 1 testing and pharmacodynamic evaluation of the HSP90 inhibitor alvespimycin (17-DMAG, KOS-1022) by the pediatric preclinical testing program. 
  • Stress is good and bad for tumors. 
  • Studies on the role of basic fibroblast growth factor in vivo: inability of neutralizing antibodies to block tumor growth. 
  • Suppression of tumor formation in vivo by expression of the JE gene in malignant cells. 
  • Surface antigenic characteristics of human glial brain tumor cells. 
  • Surface antigens of human glioma cells shared with normal adult and fetal brain. 
  • Surface morphology of normal and neoplastic rat cells. 
  • Survivin DNA vaccine generated specific antitumor effects in pancreatic carcinoma and lymphoma mouse models. 
  • Synergism between BCNU and irradiation in the treatment of anaplastic gliomas. An in vivo study using the avian sarcoma virus-induced glioma model. 
  • Synergy between tumor immunotherapy and antiangiogenic therapy. 
  • Systemic vector leakage and transgene expression by intratumorally injected recombinant adenovirus vectors. 
  • Targeted drug delivery to C6 glioma by transferrin-coupled liposomes. 
  • Targeted suppression of beta-catenin blocks intestinal adenoma formation in APC Min mice. 
  • Targeting ABL1-mediated oxidative stress adaptation in fumarate hydratase-deficient cancer. 
  • Targeting PIM Kinase with PD1 Inhibition Improves Immunotherapeutic Antitumor T-cell Response. 
  • Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. 
  • Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis. 
  • Targeting miR-23a in CD8+ cytotoxic T lymphocytes prevents tumor-dependent immunosuppression. 
  • Targeting of cytotoxic somatostatin analog AN-238 to somatostatin receptor subtypes 5 and/or 3 in experimental pancreatic cancers. 
  • Temperature measurements in normal and tumor tissue of dogs undergoing whole body hyperthermia. 
  • Temporal changes in PO2 of R3230AC tumors in Fischer-344 rats. 
  • Temporal dynamics of Wnt-dependent transcriptome reveal an oncogenic Wnt/MYC/ribosome axis. 
  • Testing of the topoisomerase 1 inhibitor Genz-644282 by the pediatric preclinical testing program. 
  • The Smads: transcriptional regulation and mouse models. 
  • The coiled-coil domain and Tyr177 of bcr are required to induce a murine chronic myelogenous leukemia-like disease by bcr/abl. 
  • The effect of protein nutrition on host and tumor metabolism. 
  • The fine structure of canine gliomas and intracranial sarcomas induced by the Schmidt-Ruppin strain of the Rous sarcoma virus. 
  • The induction of intractranial neoplasms by the inoculation of avian sarcoma virus in perinatal and adult rats. 
  • The induction of ornithine decarboxylase in cultured hepatoma cells. 
  • The relationship of modulation of major histocompatibility complex class I antigens to retrovirus transformation in rat cell lines. 
  • The role of ribosomal subunits and 80-S monomers in polysome formation in an ascites tumour cell. 
  • The tumor dormant state. 
  • The tumor dormant state. Comparison of L5178Y cells used to establish dormancy with those that emerge after its termination. 
  • The tumor dormant state. Quantitation of L5178Y cells and host immune responses during the establishment and course of dormancy in syngeneic DBA/2 mice. 
  • The unique identity of rat hepatoma phenylalanine hydroxylase. 
  • Therapy of malignant hamster insulinomas with monoamine precursors. 
  • Thermal dose is related to duration of local control in canine sarcomas treated with thermoradiotherapy. 
  • Thermosensitive liposomes: extravasation and release of contents in tumor microvascular networks. 
  • Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody. 
  • Transplantation of insulinoma into the diabetic Syrian hamster. 
  • Transvascular drug delivery in solid tumors. 
  • Treatment of autochthonous rat brain tumors with fractionated radiotherapy. The effects of graded radiation doses and of combined therapy with BCNU or steroids. 
  • Treatment of five subcutaneous human glioma tumor lines in athymic mice with carmustine, procarbazine, and mithramycin. 
  • Tumor blood flow: I. Blood flow in transplantable tumors during growth. 
  • Tumor resistance in rats immunized to fetal tissues. 
  • Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment. 
  • Tumor-specific anti-epidermal growth factor receptor variant III monoclonal antibodies: use of the tyramine-cellobiose radioiodination method enhances cellular retention and uptake in tumor xenografts. 
  • Tumor-targeted IL-12 combined with tumor resection yields a survival-favorable immune profile. 
  • Tumorigenic cell culture lines from a spontaneous VM/Dk murine astrocytoma (SMA). 
  • Tumour-dormant states established with L5178Y lymphoma cells in immunised syngeneic murine hosts. 
  • USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds. 
  • Use of nitroprusside to increase tissue temperature during local hyperthermia in normal and tumor-bearing dogs. 
  • Vascular permeability in a human tumour xenograft: molecular charge dependence. 
  • Vertical suppression of the EGFR pathway prevents onset of resistance in colorectal cancers. 
  • Viral infection-homograft interactions in a murine model. 
  • Viral neoplastic transformation of hamster prostate tissue in vitro. 
  • Virus-cell relationships in dog brain tumors induced with Schmidt-Ruppin Rous sarcoma virus. 
  • Virus-induced experimental brain tumors and putative associations of viruses with human brain tumors: a review. 
  • Vulnerabilities in mIDH2 AML confer sensitivity to APL-like targeted combination therapy. 
  • Will hyperthermia conquer the elusive hypoxic cell? Implications of heat effects on tumor and normal-tissue microcirculation. 
  • [Antitumoral action of interferons and interleukins in combination with radiotherapy. Part I: immunologic basis]. 
  • [Chicken RNA tumor viruses: a model for virus-induced carcinogenesis]. 
  • [Effect of light deprivation on homeostasis, life span and development of spontaneous tumors in HER-2/neu transgenic mice] 
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  Keywords of People

  • Cianciolo, George James, Associate Professor Emeritus of Pathology, Pathology
  • Dement, John McCray, Professor Emeritus in Family Medicine and Community Health, Family Medicine & Community Health,Occupational & Environmental Medicine
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • Palmer, Gregory M., Associate Professor of Radiation Oncology, Radiation Oncology
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Biomedical Engineering
  • Sullivan, Daniel Carl, Professor Emeritus of Radiology, Radiology
  • Wax, Adam P., Professor of Biomedical Engineering, Biomedical Engineering