Neovascularization, Pathologic

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  Subject Areas on Research

  • A 3D Poly(ethylene glycol)-based Tumor Angiogenesis Model to Study the Influence of Vascular Cells on Lung Tumor Cell Behavior. 
  • A PK2/Bv8/PROK2 antagonist suppresses tumorigenic processes by inhibiting angiogenesis in glioma and blocking myeloid cell infiltration in pancreatic cancer. 
  • A Phase I/biomarker study of bevacizumab in combination with CNTO 95 in patients with advanced solid tumors. 
  • A comparison of antiangiogenic therapies for the prevention of liver metastases. 
  • A double hit to kill tumor and endothelial cells by TRAIL and antiangiogenic 3TSR. 
  • A genome-wide association study identified a novel genetic loci STON1-GTF2A1L/LHCGR/FSHR for bilaterality of neovascular age-related macular degeneration. 
  • A novel angiopoietin-derived peptide displays anti-angiogenic activity and inhibits tumour-induced and retinal neovascularization. 
  • A novel antisense inhibitor of MMP-9 attenuates angiogenesis, human prostate cancer cell invasion and tumorigenicity. 
  • A novel rodent mammary window of orthotopic breast cancer for intravital microscopy. 
  • A novel, clinically relevant animal model of metastatic pancreatic adenocarcinoma biology and therapy. 
  • A review of VEGF/VEGFR-targeted therapeutics for recurrent glioblastoma. 
  • A study of dendritic and endothelial cell interactions in colon cancer in a cell line and small mammal model. 
  • A systems biology perspective on sVEGFR1: its biological function, pathogenic role and therapeutic use. 
  • A systems biology view of cancer. 
  • ACRIN 6684: Assessment of Tumor Hypoxia in Newly Diagnosed Glioblastoma Using 18F-FMISO PET and MRI. 
  • Abnormal angiogenesis in diabetes mellitus. 
  • Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression. 
  • Activation of vascular endothelial growth factor receptor-1 sustains angiogenesis and Bcl-2 expression via the phosphatidylinositol 3-kinase pathway in endothelial cells. 
  • Acute pancreatitis associated with administration of a nitric oxide synthase inhibitor in tumor-bearing dogs. 
  • Adeno-associated virus-mediated antiangiogenic gene therapy with thrombospondin-1 type 1 repeats and endostatin. 
  • Adventures within the speckled band: heterogeneity, angiogenesis, and balanced inflammation in the tuberculous granuloma. 
  • Age-related retinal vasculopathy. 
  • Alginate encapsulation is a highly reproducible method for tumor cell implantation in dorsal skinfold chambers. 
  • Alternatively spliced human tissue factor promotes tumor growth and angiogenesis in a pancreatic cancer tumor model. 
  • An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype. 
  • An experimental model of ectropion uveae and iris neovascularization in the cat. 
  • Angiogenesis and growth of isografted bone: quantitative in vivo assay in nude mice. 
  • Angiogenesis and molecular biologic substaging in patients with stage I non-small cell lung cancer. 
  • Angiogenesis as a predictor of survival after surgical resection for stage I non-small-cell lung cancer. 
  • Angiogenesis in fatal acute Kawasaki disease coronary artery and myocardium. 
  • Angiogenesis in neuroblastoma. 
  • Angiogenesis in non-small cell lung cancer. 
  • Angiogenesis pathway inhibitors. 
  • Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice. 
  • Angiogenesis, p53, bcl-2 and Ki-67 in the progression of prostate cancer after radical prostatectomy. 
  • Angiogenesis. 
  • Angiogenesis: an adaptive dynamic biological patterning problem. 
  • Angiomirs expression profiling in diffuse large B-Cell lymphoma. 
  • Angiostatin and anti-angiogenic therapy in human disease. 
  • Angiostatin binds ATP synthase on the surface of human endothelial cells. 
  • Angiostatin is directly cytotoxic to tumor cells at low extracellular pH: a mechanism dependent on cell surface-associated ATP synthase. 
  • Angiotropism of human prostate cancer cells: implications for extravascular migratory metastasis. 
  • Anti-VEGF therapies in the clinic. 
  • Anti-angiogenic therapy for high-grade glioma. 
  • Anti-angiogenic therapy in renal cell cancer. 
  • Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP(5+), via suppression of oxidative stress in a mouse model of breast tumor. 
  • Antiangiogenic agents in combination with chemotherapy for the treatment of epithelial ovarian cancer. 
  • Antiangiogenic agents protect liver sinusoidal lining cells from cold preservation injury in rat liver transplantation. 
  • Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2. 
  • Antiangiogenic therapies in epithelial ovarian cancer. 
  • Antiangiogenic therapy for high-grade glioma. 
  • Antiangiogenic therapy for primary liver cancer: correlation of changes in dynamic contrast-enhanced magnetic resonance imaging with tissue hypoxia markers and clinical response. 
  • Antiangiogenic treatment with the three thrombospondin-1 type 1 repeats recombinant protein in an orthotopic human pancreatic cancer model. 
  • Antiangiogenic treatment with three thrombospondin-1 type 1 repeats versus gemcitabine in an orthotopic human pancreatic cancer model. 
  • Antibody-directed coupling of endoglin and MMP-14 is a key mechanism for endoglin shedding and deregulation of TGF-β signaling. 
  • Antitumor and Antiangiogenic Effects of Aspirin-PC in Ovarian Cancer. 
  • Antitumorigenesis of antioxidants in a transgenic Rac1 model of Kaposi's sarcoma. 
  • Assessing the ability of the antiangiogenic and anticytokine agent thalidomide to modulate radiation-induced lung injury. 
  • Atezolizumab with or without bevacizumab in unresectable hepatocellular carcinoma (GO30140): an open-label, multicentre, phase 1b study. 
  • Atherosclerosis: a cancer of the blood vessels? 
  • Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor. 
  • Automated measurement of microcirculatory blood flow velocity in pulmonary metastases of rats. 
  • Available volume fraction of macromolecules in the extravascular space of a fibrosarcoma: implications for drug delivery. 
  • Bevacizumab (Avastin®) in cancer treatment: A review of 15 years of clinical experience and future outlook. 
  • Bilateral intraocular hemorrhage from vascularization of cataract wounds. 
  • Biologic effects of platelet-derived growth factor receptor α blockade in uterine cancer. 
  • Biomarkers of response and resistance to antiangiogenic therapy. 
  • Biomimetic Hydrogels with Immobilized EphrinA1 for Therapeutic Angiogenesis 
  • Biphasic induction of immediate early gene expression accompanies activity-dependent angiogenesis and myofiber remodeling of rabbit skeletal muscle. 
  • Blood vessel maturation in human uveal melanoma: spatial distribution of neovessels and mature vasculature. 
  • Bombesin-like peptides modulate alveolarization and angiogenesis in bronchopulmonary dysplasia. 
  • Breakdown of the blood-retinal barrier in a model of retinal neovascularization. 
  • CD34 immunohistochemical assessment of angiogenesis as a prognostic marker for prostate cancer recurrence after radical prostatectomy. 
  • CD4(+) T cells contribute to the remodeling of the microenvironment required for sustained tumor regression upon oncogene inactivation. 
  • CD44+/CD24- breast cancer cells isolated from MCF-7 cultures exhibit enhanced angiogenic properties. 
  • CLT1 targets bladder cancer through integrin α5β1 and CLIC3. 
  • CXCR2 promotes ovarian cancer growth through dysregulated cell cycle, diminished apoptosis, and enhanced angiogenesis. 
  • Carbonic anhydrase IX in early-stage non-small cell lung cancer. 
  • Caspase 3 in dying tumor cells mediates post-irradiation angiogenesis. 
  • Celecoxib inhibits vascular endothelial growth factor expression in and reduces angiogenesis and metastasis of human pancreatic cancer via suppression of Sp1 transcription factor activity. 
  • Chemopreventive apigenin controls UVB-induced cutaneous proliferation and angiogenesis through HuR and thrombospondin-1. 
  • Choroidal (subretinal) neovascularization secondary to choroidal nevus and successful treatment with argon laser photocoagulation. Case reports and review of literature. 
  • Circulating markers of vascular injury and angiogenesis in antineutrophil cytoplasmic antibody-associated vasculitis. 
  • Clinicopathologic correlation of spontaneous retinal pigment epithelial tears with choroidal neovascular membranes in age-related macular degeneration. 
  • Co-expression of angiogenic markers and associations with prognosis in advanced epithelial ovarian cancer: a Gynecologic Oncology Group study. 
  • Combined hyperspectral and spectral domain optical coherence tomography microscope for noninvasive hemodynamic imaging. 
  • Commentary: Connecting the dots: Coronary artery development as a combination of vasculogenesis and angiogenesis. 
  • Common responses of tumors and wounds to hypoxia. 
  • Complete longitudinal analyses of the randomized, placebo-controlled, phase III trial of sunitinib in patients with gastrointestinal stromal tumor following imatinib failure. 
  • Complete preoperative embolization of hemangioblastoma vessels with Onyx 18. 
  • Concordance of hypervascular liver nodule characterization between the organ procurement and transplant network and liver imaging reporting and data system classifications. 
  • Conditional HIF-1 induction produces multistage neovascularization with stage-specific sensitivity to VEGFR inhibitors and myeloid cell independence. 
  • Constitutive and inducible interleukin 8 expression by hypoxia and acidosis renders human pancreatic cancer cells more tumorigenic and metastatic. 
  • Continuous administration of the three thrombospondin-1 type 1 repeats recombinant protein improves the potency of therapy in an orthotopic human pancreatic cancer model. 
  • Corneal penetration of topical and subconjunctival bevacizumab. 
  • Correlation of angiogenic biomarker signatures with clinical outcomes in metastatic colorectal cancer patients receiving capecitabine, oxaliplatin, and bevacizumab. 
  • Cross-talk between Schwann cells and neuroblasts influences the biology of neuroblastoma xenografts. 
  • Current concepts in the management of central retinal vein occlusion. 
  • Current insights on the biology and clinical aspects of VEGF regulation. 
  • Cutaneous lesions of secondary syphilis are highly angiogenic. 
  • Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response. 
  • Cyclopropane Modification of Trehalose Dimycolate Drives Granuloma Angiogenesis and Mycobacterial Growth through Vegf Signaling. 
  • Detection of tumor angiogenesis in vivo by alphaVbeta3-targeted magnetic resonance imaging. 
  • Development of biologic markers of response and assessment of antiangiogenic activity in a clinical trial of human recombinant endostatin. 
  • Development of retinal neovascularisation in vascular occlusive disease. 
  • Dietary glycine inhibits angiogenesis during wound healing and tumor growth. 
  • Different patterns of angiogenesis in sarcomas and carcinomas. 
  • Differential effects of vascular endothelial growth factor receptor-2 inhibitor ZD6474 on circulating endothelial progenitors and mature circulating endothelial cells: implications for use as a surrogate marker of antiangiogenic activity. 
  • Diffuse infiltrating retinoblastoma presenting as a spontaneous hyphema. 
  • Direct demonstration of instabilities in oxygen concentrations within the extravascular compartment of an experimental tumor. 
  • Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1alpha, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer. 
  • Distinct Angiogenic Changes during Carcinogenesis Defined by Novel Label-Free Dark-Field Imaging in a Hamster Cheek Pouch Model. 
  • Down-regulation of platelet-derived growth factor-D inhibits cell growth and angiogenesis through inactivation of Notch-1 and nuclear factor-kappaB signaling. 
  • Dual Metronomic Chemotherapy with Nab-Paclitaxel and Topotecan Has Potent Antiangiogenic Activity in Ovarian Cancer. 
  • Dual-energy MDCT in hypervascular liver tumors: effect of body size on selection of the optimal monochromatic energy level. 
  • Dying glioma cells establish a proangiogenic microenvironment through a caspase 3 dependent mechanism. 
  • Dysregulation of the mTOR pathway secondary to mutations or a hostile microenvironment contributes to cancer and poor wound healing. 
  • ETC-159, an Upstream Wnt inhibitor, Induces Tumour Necrosis via Modulation of Angiogenesis in Osteosarcoma. 
  • Early breast cancer therapy and cardiovascular injury. 
  • Early malaria infection, dysregulation of angiogenesis, metabolism and inflammation across pregnancy, and risk of preterm birth in Malawi: A cohort study. 
  • Early-outgrowth of endothelial progenitor cells can function as antigen-presenting cells. 
  • Effect of aerobic exercise on tumor physiology in an animal model of human breast cancer. 
  • Effect of inhibitors of arachidonic acid metabolism on corneal neovascularization in the rat. 
  • Effect of pazopanib on tumor microenvironment and liposome delivery. 
  • Effect of radiologists' experience with an adaptive statistical iterative reconstruction algorithm on detection of hypervascular liver lesions and perception of image quality. 
  • Effect of rapamycin alone and in combination with antiangiogenesis therapy in an orthotopic model of human pancreatic cancer. 
  • Effects of high-dose microbeam irradiation on tumor microvascular function and angiogenesis. 
  • Effects of the proteasome inhibitor PS-341 on apoptosis and angiogenesis in orthotopic human pancreatic tumor xenografts. 
  • Effects of tumor microenvironment heterogeneity on nanoparticle disposition and efficacy in breast cancer tumor models. 
  • Efficacy of systemic administration of SDF-1 in a model of vascular insufficiency: support for an endothelium-dependent mechanism. 
  • Electroretinographic findings in sickle cell retinopathy. 
  • Emerging therapeutic approaches in the management of retinal angiogenesis and edema. 
  • Endoglin interacts with VEGFR2 to promote angiogenesis. 
  • Endothelial TRPV4 channels prevent tumor growth and metastasis via modulation of tumor angiogenesis and vascular integrity. 
  • Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: role of vascular endothelial growth factor. 
  • Endothelial cell surface ATP synthase-triggered caspase-apoptotic pathway is essential for k1-5-induced antiangiogenesis. 
  • Engineered transcription factors for therapeutic angiogenesis. 
  • Environmental oxygen regulates astrocyte proliferation to guide angiogenesis during retinal development. 
  • Epidermal growth factor receptor blockade with C225 plus gemcitabine results in regression of human pancreatic carcinoma growing orthotopically in nude mice by antiangiogenic mechanisms. 
  • Erythropoietin blockade inhibits the induction of tumor angiogenesis and progression. 
  • Erythropoietin receptor contributes to melanoma cell survival in vivo. 
  • Evaluation of KRAS mutations, angiogenic biomarkers, and DCE-MRI in patients with advanced non-small-cell lung cancer receiving sorafenib. 
  • Evaluation of choroidal neovascular membranes by Octopus perimetry. 
  • Exercise modulation of the host-tumor interaction in an orthotopic model of murine prostate cancer. 
  • Experimental autoimmune uveoretinitis and pinealitis induced by interphotoreceptor retinoid-binding protein and S-antigen: induction of intraretinal and subretinal neovascularization. 
  • Exploring the role of HIF-1 in early angiogenesis and response to radiotherapy. 
  • Expression of EGFR, VEGF, and NOTCH1 suggest differences in tumor angiogenesis in HPV-positive and HPV-negative head and neck squamous cell carcinoma. 
  • Expression of Tie2/Tek in breast tumour vasculature provides a new marker for evaluation of tumour angiogenesis. 
  • Expression of platelet-derived endothelial cell growth factor correlates with good prognosis in patients with colorectal carcinoma. 
  • Extracellular matrix protein betaig-h3/TGFBI promotes metastasis of colon cancer by enhancing cell extravasation. 
  • Extracellular vesicles from endometriosis patients are characterized by a unique miRNA-lncRNA signature. 
  • Feasibility of laser targeted photo-occlusion of ocular vessels. 
  • Feasibility of laser-targeted photoocclusion of the choriocapillary layer in rats. 
  • First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF-κB pathway. 
  • Fluorescence ratio imaging of interstitial pH in solid tumours: effect of glucose on spatial and temporal gradients. 
  • Functional computed tomography imaging of tumor-induced angiogenesis: preliminary results of new tracer kinetic modeling using a computer discretization approach. 
  • Functional imaging of tumor vasculature using iodine and gadolinium-based nanoparticle contrast agents: a comparison of spectral micro-CT using energy integrating and photon counting detectors. 
  • Functional significance of Tie2 signaling in the adult vasculature. 
  • Fundamentals of quantitative dynamic contrast-enhanced MR imaging. 
  • Gene therapy and genomic strategies for cardiovascular surgery: The emerging field of surgiomics. 
  • Gene therapy for lung cancer. 
  • Gene transfer of pigment epithelium-derived factor suppresses tumor growth and angiogenesis in a hepatoblastoma xenograft model. 
  • Gene variants in angiogenesis and lymphangiogenesis and cutaneous melanoma progression. 
  • Generation of a syngeneic mouse model to study the effects of vascular endothelial growth factor in ovarian carcinoma. 
  • Genetic considerations relevant to intracranial hemorrhage and brain arteriovenous malformations. 
  • Genetic variation determines VEGF-A plasma levels in cancer patients. 
  • Glioblastoma multiforme: an emerging paradigm of anti-VEGF therapy. 
  • Glomeruloid microvascular proliferation is associated with lack of response to chemotherapy in breast cancer. 
  • Growth factor control of extracellular proteolysis. 
  • HER-2 gene amplification correlates with higher levels of angiogenesis and lower levels of hypoxia in primary breast tumors. 
  • Her2/neu signaling blockade improves tumor oxygenation in a multifactorial fashion in Her2/neu+ tumors. 
  • High angiogenic activity in cells isolated from cystic hygroma: role of bFGF. 
  • Histopathology of experimental preretinal neovascularization. 
  • Host pigment epithelium-derived factor (PEDF) prevents progression of liver metastasis in a mouse model of uveal melanoma. 
  • How reader perception of capsule affects interpretation of washout in hypervascular liver nodules in patients at risk for hepatocellular carcinoma. 
  • Human recombinant erythropoietin (rEpo) has no effect on tumour growth or angiogenesis. 
  • Hyperspectral imaging of hemoglobin saturation in tumor microvasculature and tumor hypoxia development. 
  • Hypoxia, angiogenesis, and lung cancer. 
  • Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells. 
  • IL-17A Contributes to the Pathogenesis of Endometriosis by Triggering Proinflammatory Cytokines and Angiogenic Growth Factors. 
  • Identification of a Genomic Region between SLC29A1 and HSP90AB1 Associated with Risk of Bevacizumab-Induced Hypertension: CALGB 80405 (Alliance). 
  • Identification of tumor angiogenesis-related genes by subtractive hybridization. 
  • Identifying Blood-Based Protein Biomarkers for Antiangiogenic Agents in the Clinic: A Decade of Progress. 
  • Images in cardiovascular medicine. Noninvasive characterization of left atrial mass. 
  • Imaging of angiogenesis: clinical techniques and novel imaging methods. 
  • Immunologic Effects of Stereotactic Body Radiotherapy in Dogs with Spontaneous Tumors and the Impact of Intratumoral OX40/TLR Agonist Immunotherapy. 
  • Immunosurveillance by antiangiogenesis: tumor growth arrest by T cell-derived thrombospondin-1. 
  • Impaired angiogenesis after hindlimb ischemia in type 2 diabetes mellitus: differential regulation of vascular endothelial growth factor receptor 1 and soluble vascular endothelial growth factor receptor 1. 
  • Implications of Increase in Vascular Permeability in Tumors by VEGF: A Commentary on the Pioneering Work of Harold Dvorak. 
  • In vivo BOLD contrast MRI mapping of subcutaneous vascular function and maturation: validation by intravital microscopy. 
  • In vivo characterization of tumor vasculature using iodine and gold nanoparticles and dual energy micro-CT. 
  • In vivo imaging of tumor-propagating cells, regional tumor heterogeneity, and dynamic cell movements in embryonal rhabdomyosarcoma. 
  • In vivo measurement of corneal angiogenesis with video data acquisition and computerized image analysis. 
  • In vivo molecular analysis of cytokines in a murine model of ocular onchocerciasis. I. Up-regulation of IL-4 and IL-5 mRNAs and not IL-2 and IFN gamma mRNAs in the cornea due to experimental interstitial keratitis. 
  • In vivo optical molecular imaging and analysis in mice using dorsal window chamber models applied to hypoxia, vasculature and fluorescent reporters. 
  • In vivo photoacoustic tomography of total blood flow and potential imaging of cancer angiogenesis and hypermetabolism. 
  • In vivo tumor targeting by a NGR-decorated micelle of a recombinant diblock copolypeptide. 
  • Increased microvascular density predicts relapse in Wilms' tumor. 
  • Independent prognostic relevance of microvessel density in advanced epithelial ovarian cancer and associations between CD31, CD105, p53 status, and angiogenic marker expression: A Gynecologic Oncology Group study. 
  • Induction of CD4(+) and CD8(+) T-cell responses to the human stromal antigen, fibroblast activation protein: implication for cancer immunotherapy. 
  • Inflammatory pulmonary nodules in Kawasaki disease. 
  • Inherited determinants of ovarian cancer survival. 
  • Inhibiting the inhibitor: targeting vascular endothelial protein tyrosine phosphatase to promote tumor vascular maturation. 
  • Inhibition of SRC expression and activity inhibits tumor progression and metastasis of human pancreatic adenocarcinoma cells in an orthotopic nude mouse model. 
  • Inhibition of constitutive NF-kappa B activity by I kappa B alpha M suppresses tumorigenesis. 
  • Inhibition of corneal neovascularization in the rat by SK&F 86002, a dual inhibitor of arachidonic acid metabolism. 
  • Inhibition of in vivo tumor angiogenesis and growth via systemic delivery of an angiopoietin 2-specific RNA aptamer. 
  • Inhibition of rat corneal angiogenesis by a nuclease-resistant RNA aptamer specific for angiopoietin-2. 
  • Inhibition of tumor angiogenesis using a soluble receptor establishes a role for Tie2 in pathologic vascular growth. 
  • Inhibition of tumor growth by systemic treatment with thrombospondin-1 peptide mimetics. 
  • Inhibition of tumor growth by targeting tumor endothelium using a soluble vascular endothelial growth factor receptor. 
  • Initial stages of tumor cell-induced angiogenesis: evaluation via skin window chambers in rodent models. 
  • Initial testing of the VEGFR inhibitor AZD2171 by the pediatric preclinical testing program. 
  • Integrin alpha 6 regulates glioblastoma stem cells. 
  • Inter- and intra-rater reproducibility of quantitative dynamic contrast enhanced MRI using TWIST perfusion data in a uterine fibroid model. 
  • Interception of host angiogenic signalling limits mycobacterial growth. 
  • Interleukin-33 modulates inflammation in endometriosis. 
  • Intraoperative fluorescein angioscopy in subretinal surgery. 
  • Intravital fluorescence facilitates measurement of multiple physiologic functions and gene expression in tumors of live animals. 
  • Intravital microscopy evaluation of angiogenesis and its effects on glucose sensor performance. 
  • Investigation of the Lack of Angiogenesis in the Formation of Lymph Node Metastases. 
  • In Vivo Effects of Long-Term Cigarette Smoke Exposure on Mammary Tissue in Mice. 
  • Ischemic central retinal vein occlusion and retinitis pigmentosa: lower risk of neovascularization? 
  • LY2109761, a novel transforming growth factor beta receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis. 
  • Leveraging Nuclear Receptors as Targets for Pathological Ocular Vascular Diseases. 
  • Liver: single breath-hold dynamic subtraction CT with multi-detector row helical technology feasibility study. 
  • Loss of basal cells precedes bronchiolitis obliterans-like pathological changes in a murine model of chlorine gas inhalation. 
  • Macrophage-derived Hedgehog ligands promotes fibrogenic and angiogenic responses in human schistosomiasis mansoni. 
  • Macrophages Facilitate Resistance to Anti-VEGF Therapy by Altered VEGFR Expression. 
  • Magnetic resonance imaging applications in the evaluation of tumor angiogenesis. 
  • Magnetic resonance imaging-measured blood flow change after antiangiogenic therapy with PTK787/ZK 222584 correlates with clinical outcome in metastatic renal cell carcinoma. 
  • Magnetic resonance spectroscopy as an early indicator of response to anti-angiogenic therapy in patients with recurrent glioblastoma: RTOG 0625/ACRIN 6677. 
  • Mast cells impair the development of protective anti-tumor immunity. 
  • Measuring tumor cycling hypoxia and angiogenesis using a side-firing fiber optic probe. 
  • Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: intravital microscopy and measurement of vascular permeability. 
  • Mechanisms of action of rapamycin in gliomas. 
  • Metaboloptics: Visualization of the tumor functional landscape via metabolic and vascular imaging. 
  • Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis. 
  • Modulation of circulating angiogenic factors and tumor biology by aerobic training in breast cancer patients receiving neoadjuvant chemotherapy. 
  • Modulation of circulating protein biomarkers following TRC105 (anti-endoglin antibody) treatment in patients with advanced cancer. 
  • Modulation of murine breast tumor vascularity, hypoxia and chemotherapeutic response by exercise. 
  • Molecular imaging of hypoxia. 
  • Myoepithelial-specific CD44 shedding contributes to the anti-invasive and antiangiogenic phenotype of myoepithelial cells. 
  • Neo-angiogenesis and the premalignant micro-circulatory augmentation of early colon carcinogenesis. 
  • Neointimal inflammation and adventitial angiogenesis correlate with severity of cardiac allograft vasculopathy in pediatric recipients. 
  • Neovascularization in atherectomy specimens from patients with unstable angina: implications for pathogenesis of unstable angina. 
  • Nerve ultrasound in CIDP: poly-parameters for polyneuropathies. 
  • Neutrophil recruitment and function in endometriosis patients and a syngeneic murine model. 
  • Noncoding RNAs Regulating Cancer Signaling Network. 
  • Nontoxic nerve guide tubes support neovascular growth in transected rat optic nerve. 
  • Novel therapeutic approaches to advanced prostate cancer. 
  • Observation of incipient tumor angiogenesis that is independent of hypoxia and hypoxia inducible factor-1 activation. 
  • Optical imaging of tumor hypoxia dynamics. 
  • Oral administration of an Enoki mushroom protein FVE activates innate and adaptive immunity and induces anti-tumor activity against murine hepatocellular carcinoma. 
  • Overexpression of Four Joint Box-1 Protein (FJX1) in Eutopic Endometrium From Women With Endometriosis. 
  • PET of hypoxia and perfusion with 62Cu-ATSM and 62Cu-PTSM using a 62Zn/62Cu generator. 
  • PI-3 kinase-PTEN signaling node: an intercept point for the control of angiogenesis. 
  • PPARβ/δ selectively regulates phenotypic features of age-related macular degeneration. 
  • PTEN Expression as a Predictor of Response to Focal Adhesion Kinase Inhibition in Uterine Cancer. 
  • Pericyte-like location of GFP-tagged melanoma cells: ex vivo and in vivo studies of extravascular migratory metastasis. 
  • Pericytic-like angiotropism of glioma and melanoma cells. 
  • Pharmacodynamic analysis of target inhibition and endothelial cell death in tumors treated with the vascular endothelial growth factor receptor antagonists SU5416 or SU6668. 
  • Pharmacodynamic and pharmacokinetic study of chronic low-dose metronomic cyclophosphamide therapy in mice. 
  • Phase III Trial of Adjuvant Sunitinib in Patients with High-Risk Renal Cell Carcinoma: Exploratory Pharmacogenomic Analysis. 
  • Phosphorylated epidermal growth factor receptor and cyclooxygenase-2 expression in localized non-small cell lung cancer. 
  • Pigment epithelium-derived factor is an angiogenesis and lipid regulator that activates peroxisome proliferator-activated receptor alpha. 
  • Pigment epithelium-derived factor stimulates tumor macrophage recruitment and is downregulated by the prostate tumor microenvironment. 
  • Pigment epithelium-derived factor: a potent inhibitor of angiogenesis. 
  • Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity. 
  • Potential for transcatheter application of antisense oligonucleotides for the treatment of vascular diseases. 
  • Potential importance of tissue angiotensin-converting enzyme inhibition in preventing neointima formation. 
  • Predicting grade of cerebral glioma using vascular-space occupancy MR imaging. 
  • Preeclampsia and future cardiovascular disease: potential role of altered angiogenesis and insulin resistance. 
  • Preferential extravasation and accumulation of liposomal vincristine in tumor comparing to normal tissue enhances antitumor activity. 
  • Preoperative chemoradiation and pancreaticoduodenectomy for adenocarcinoma of the pancreas. 
  • Prognostic significance of differential expression of angiogenic genes in women with high-grade serous ovarian carcinoma. 
  • Prostate cancer: status of current treatments and emerging antisense-based therapies. 
  • Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model. 
  • Proteasome inhibition with bortezomib induces cell death in GBM stem-like cells and temozolomide-resistant glioma cell lines, but stimulates GBM stem-like cells' VEGF production and angiogenesis. 
  • Proteome analysis of the rat cornea during angiogenesis. 
  • Quantification metrics for telangiectasia using optical coherence tomography. 
  • Quantification of longitudinal tissue pO2 gradients in window chamber tumours: impact on tumour hypoxia. 
  • Quantitation of corneal neovascularization using computerized image analysis. 
  • Quantitative analysis of biomarkers defines an optimal biological dose for recombinant human endostatin in primary human tumors. 
  • Quantitative angiogenesis assays: progress and problems. 
  • Rac1/Pak1/p38/MMP-2 Axis Regulates Angiogenesis in Ovarian Cancer. 
  • Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules. 
  • Raising the bar: how HIF-1 helps determine tumor radiosensitivity. 
  • Randomized Phase III Trial of Gemcitabine and Cisplatin With Bevacizumab or Placebo in Patients With Advanced Urothelial Carcinoma: Results of CALGB 90601 (Alliance). 
  • Rapid determination of oxygen saturation and vascularity for cancer detection. 
  • Rapid growth of cutaneous metastases after surgical resection of thrombospondin-secreting small blue round cell tumor of childhood. 
  • Re: initial stages of tumor cell-induced angiogenesis: evaluation via skin window chambers in rodent models. 
  • Recent advances in the treatment of pediatric brain tumors. 
  • Recombinant human endostatin could eliminate the pro-angiogenesis priority of SP cells sorted from non-small cell lung cancer cells. 
  • Reduction of human prostate tumor vascularity by the alpha1-adrenoceptor antagonist terazosin. 
  • Reduction of wound angiogenesis in patients treated with BMS-275291, a broad spectrum matrix metalloproteinase inhibitor. 
  • Regional effects of an antivascular endothelial growth factor receptor monoclonal antibody on receptor phosphorylation and apoptosis in human 253J B-V bladder cancer xenografts. 
  • Regression of metastatic breast cancer in a patient treated with the anti-angiogenic drug TNP-470. 
  • Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. 
  • Relationships between cycling hypoxia, HIF-1, angiogenesis and oxidative stress. 
  • Response to antiangiogenesis therapy in a patient with advanced adult-type testicular granulosa cell tumor. 
  • Response to: 'Comment on Transitioning to intravitreal aflibercept following a previous treat-and-extend dosing regimen in neovascular age-related macular degeneration: 24-month results'. 
  • Responses of vascular endothelial cells to angiogenic signaling are important for tumor cell survival. 
  • Results of peripheral laser photocoagulation in pars planitis. 
  • Retinal neovascularisation arising from hyalinised blood vessels. 
  • Retrobulbar anesthesia and eyelid closure--effect on corneal angiogenesis. 
  • Risk of missing angle neovascularization by omitting screening gonioscopy in patients with diabetes mellitus. 
  • Role of elongin-binding domain of von Hippel Lindau gene product on HuR-mediated VPF/VEGF mRNA stability in renal cell carcinoma. 
  • Role of exosomes in treatment of hepatocellular carcinoma. 
  • Role of incipient angiogenesis in cancer metastasis. 
  • Role of vascular leukocytes in ovarian cancer neovascularization. 
  • Rubeosis iridis: preoperative iris fluorescein angiography and periocular steroids. 
  • SPARC is a key Schwannian-derived inhibitor controlling neuroblastoma tumor angiogenesis. 
  • Secreted frizzle-related protein 2 stimulates angiogenesis via a calcineurin/NFAT signaling pathway. 
  • Selective inhibition of matrix metalloproteinase-14 blocks tumor growth, invasion, and angiogenesis. 
  • Selective visualization of choroidal neovascular membranes. 
  • Separating the wheat from the chaff: focus on "in silico data filtering to identify new angiogenesis targets from a large in vitro gene profile data set". 
  • Serum vascular endothelial growth factor is elevated in cystic fibrosis and decreases with treatment of acute pulmonary exacerbation. 
  • Sickle erythrocytes target cytotoxics to hypoxic tumor microvessels and potentiate a tumoricidal response. 
  • Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1. 
  • Silicone oil for progressive anterior ocular neovascularization after failed diabetic vitrectomy. 
  • Simultaneous in vivo optical quantification of key metabolic and vascular endpoints reveals tumor metabolic diversity in murine breast tumor models. 
  • Spatiotemporal distribution modeling of PET tracer uptake in solid tumors. 
  • Spectral imaging facilitates visualization and measurements of unstable and abnormal microvascular oxygen transport in tumors. 
  • Stable RNA interference-mediated suppression of cyclophilin A diminishes non-small-cell lung tumor growth in vivo. 
  • Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis. 
  • Statins activate the canonical hedgehog-signaling and aggravate non-cirrhotic portal hypertension, but inhibit the non-canonical hedgehog signaling and cirrhotic portal hypertension. 
  • Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor. 
  • Steroids for restenosis: strike three! 
  • Stromal gene signatures in large-B-cell lymphomas. 
  • Structural adaptation and heterogeneity of normal and tumor microvascular networks. 
  • Structural adaptation of normal and tumour vascular networks. 
  • Studies Introducing Costimulation Blockade for Vascularized Composite Allografts in Nonhuman Primates. 
  • Studying the influence of angiogenesis in in vitro cancer model systems. 
  • Subretinal hemorrhage during fluorescein angiography. 
  • Subretinal neovascularisation in ocular toxoplasmosis. 
  • Surgical removal of subfoveal neovascularization in idiopathic juxtafoveolar retinal telangiectasis. 
  • Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients. 
  • Synergistic activity of the SRC family kinase inhibitor dasatinib and oxaliplatin in colon carcinoma cells is mediated by oxidative stress. 
  • Synergy between tumor immunotherapy and antiangiogenic therapy. 
  • Systemic overexpression of angiopoietin-2 promotes tumor microvessel regression and inhibits angiogenesis and tumor growth. 
  • Targeting PDGF receptors in cancer--rationales and proof of concept clinical trials. 
  • Targeting cell surface F1F0 ATP synthase in cancer therapy. 
  • Targeting cellular heterogeneity with CXCR2 blockade for the treatment of therapy-resistant prostate cancer. 
  • Targeting the Tie2/Tek receptor in astrocytomas. 
  • Targeting the endothelium in cancer--the importance of the interaction of hemostatic mechanisms and the vascular wall for tumor growth and angiogenesis. 
  • Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis. 
  • Targeting vascular endothelial growth factor and angiogenesis for the treatment of colorectal cancer. 
  • The NLRP3 Inflammasome May Contribute to Pathologic Neovascularization in the Advanced Stages of Diabetic Retinopathy. 
  • The Role of Angiogenesis in Hepatocellular Carcinoma. 
  • The biology of malignant gliomas--a comprehensive survey. 
  • The effect of angiostatic steroids and beta-cyclodextrin tetradecasulfate on corneal neovascularization in the rat. 
  • The effect of anti-VEGF therapy on immature myeloid cell and dendritic cells in cancer patients. 
  • The effect of oxygen on corneal neovascularization. 
  • The effect of total-body irradiation on corneal neovascularization in the Fischer 344 rat after chemical cauterization. 
  • The effects of total lymphoid irradiation upon corneal vascularization in the rat following chemical cautery. 
  • The evolving role of sonography in evaluating solid breast masses. 
  • The future of biology in driving the field of hyperthermia. 
  • The human myoepithelial cell displays a multifaceted anti-angiogenic phenotype. 
  • The novel tubulin-binding drug BTO-956 inhibits R3230AC mammary carcinoma growth and angiogenesis in Fischer 344 rats. 
  • The potential role of intrinsic hypoxia markers as prognostic variables in cancer. 
  • The prognostic significance of angiogenesis in epithelial ovarian carcinoma. 
  • The relationship between hypoxia and angiogenesis. 
  • The relationship between the tumor physiologic microenvironment and angiogenesis. 
  • The risk of missing angle neovascularization by omitting screening gonioscopy in acute central retinal vein occlusion. 
  • The role of angiogenesis in Group 3 medulloblastoma pathogenesis and survival. 
  • The role of blood-brain barrier permeability in brain tumor imaging and therapeutics. 
  • The role of dendritic cell precursors in tumour vasculogenesis. 
  • The role of microparticles in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus. 
  • The role of targeted therapy in the treatment of colorectal cancer. 
  • The search for biomarkers to direct antiangiogenic treatment in epithelial ovarian cancer. 
  • The treatment of colorectal carcinoma: standard chemotherapy and beyond. 
  • The von Hippel-Lindau protein, vascular endothelial growth factor, and kidney cancer. 
  • Theoretical simulation of oxygen transport to tumors by three-dimensional networks of microvessels. 
  • Thioredoxin and hematologic malignancies. 
  • Thrombospondin 1 inhibits inflammatory lymphangiogenesis by CD36 ligation on monocytes. 
  • Thrombospondin-1 expression in epithelial ovarian carcinoma: association with p53 status, tumor angiogenesis, and survival in platinum-treated patients. 
  • Thrombospondin-1, vascular endothelial growth factor and fibroblast growth factor-2 are key functional regulators of angiogenesis in the prostate. 
  • Thrombospondin-based antiangiogenic therapy. 
  • Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody. 
  • Tissue factor and fibrin in tumor angiogenesis. 
  • Tissue factor, thrombin, and cancer. 
  • Tolfenamic acid and pancreatic cancer growth, angiogenesis, and Sp protein degradation. 
  • Toward a systems engineering approach to cancer drug delivery. 
  • Transcriptional response to hypoxia in human tumors. 
  • Transitioning to intravitreal aflibercept following a previous treat-and-extend dosing regimen in neovascular age-related macular degeneration: 24-month results. 
  • Translational physiology: porcine models of human coronary artery disease: implications for preclinical trials of therapeutic angiogenesis. 
  • Treatment of experimental preretinal neovascularization using photodynamic thrombosis. 
  • Treatment with Imatinib in NSCLC is associated with decrease of phosphorylated PDGFR-beta and VEGF expression, decrease in interstitial fluid pressure and improvement of oxygenation. 
  • Tumor angiogenesis correlates with metastatic disease, N-myc amplification, and poor outcome in human neuroblastoma. 
  • Tumor angiogenic and hypoxic profiles predict radiographic response and survival in malignant astrocytoma patients treated with bevacizumab and irinotecan. 
  • Tumor blood flow measured by perfusion computed tomography and 15O-labeled water positron emission tomography: a comparison study. 
  • Tumor vascular permeability to a nanoprobe correlates to tumor-specific expression levels of angiogenic markers. 
  • Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment. 
  • Tumor-infiltrating dendritic cell precursors recruited by a beta-defensin contribute to vasculogenesis under the influence of Vegf-A. 
  • Tumor-promoting phorbol esters induce angiogenesis in vivo. 
  • Tumour suppressor genes and angiogenesis: the role of TP53 in fibroblasts. 
  • Uterine NK cell education: Learning the ropes in pregnancy. 
  • Utility of Serum Inflammatory Markers for Predicting Microvascular Invasion and Survival for Patients with Hepatocellular Carcinoma. 
  • VEGF and soluble VEGF receptor-1 (sFlt-1) distributions in peripheral arterial disease: an in silico model. 
  • VEGF is essential for hypoxia-inducible factor-mediated neovascularization but dispensable for endothelial sprouting. 
  • VEGF-targeted cancer therapy strategies: current progress, hurdles and future prospects. 
  • Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2. 
  • Vascular endothelial growth factor and diabetic complications. 
  • Vascular leukocytes contribute to tumor vascularization. 
  • Vascular leukocytes: a population with angiogenic and immunossuppressive properties highly represented in ovarian cancer. 
  • Vascular morphogenesis: tales of two syndromes. 
  • Vein graft neointimal hyperplasia is exacerbated by tumor necrosis factor receptor-1 signaling in graft-intrinsic cells. 
  • Visible light optical spectroscopy is sensitive to neovascularization in the dysplastic cervix. 
  • Visual outcomes following macular translocation with 360-degree peripheral retinectomy. 
  • Wilms' tumor growth is suppressed by antiangiogenic pigment epithelium-derived factor in a xenograft model. 
  • Wnts and the hallmarks of cancer. 
  • ZD6474, a novel tyrosine kinase inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor, inhibits tumor growth of multiple nervous system tumors. 
  • [A novel model for visualization of tumor cell-induced angiogenesis in vivo]. 
  • [Inhibitation of tumor angiogenesis, growth and metastasis by blocking VEGF paracrine pathway]. 
  • p38gamma mitogen-activated protein kinase is a key regulator in skeletal muscle metabolic adaptation in mice. 
• 

  Keywords of People

  • Badea, Cristian Tudorel, Professor in Radiology, Biomedical Engineering
  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Chitneni, Satish K., Associate Professor in Radiology, Radiology
  • Choi, Steven Sok, Associate Professor of Medicine, Medicine, Gastroenterology
  • Fekrat, Sharon, Professor of Ophthalmology, Ophthalmology, Vitreoretinal Diseases & Surgery
  • Gunn, Michael Dee, Professor of Medicine, Integrative Immunobiology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Muh, Carrie Rebecca, Adjunct Assistant Professor in the Department of Neurosurgery, Neurosurgery
  • Palmer, Gregory M., Associate Professor of Radiation Oncology, Radiation Oncology
  • Pang, Herbert, Adjunct Assistant Professor in the Department of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Biomedical Engineering
  • Stinnett, Sandra Sue, Associate Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics
  • Toth, Cynthia Ann, Joseph A.C. Wadsworth Distinguished Professor of Ophthalmology, Biomedical Engineering