Nerve Degeneration

• 

  Subject Areas on Research

  • 6-Hydroxydopamine injections into the nigrostriatal pathway attenuate striatal malonate and 3-nitropropionic acid lesions. 
  • A model for the computation and encoding of azimuthal information by the lateral superior olive. 
  • A novel human disease with abnormal prion protein sensitive to protease. 
  • A role for GAPDH in apoptosis and neurodegeneration. 
  • Absence of carboxypeptidase E leads to adult hippocampal neuronal degeneration and memory deficits. 
  • Active MS is associated with accelerated retinal ganglion cell/inner plexiform layer thinning. 
  • Acute N-Acetylcysteine Administration Ameliorates Loss of Olfactory Neurons Following Experimental Injury In Vivo. 
  • Age-associated insolubility of parkin in human midbrain is linked to redox balance and sequestration of reactive dopamine metabolites. 
  • Alpers' syndrome presenting with seizures and multiple stroke-like episodes in a 17-year-old male. 
  • Altered distribution of choline acetyltransferase and acetylcholinesterase activities in the developing rat dentate gyrus following entorhinal lesion. 
  • Amyloid reduction by amyloid-beta vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of Alzheimer's disease. 
  • An Antimicrobial Peptide and Its Neuronal Receptor Regulate Dendrite Degeneration in Aging and Infection. 
  • AnkyrinG is required for clustering of voltage-gated Na channels at axon initial segments and for normal action potential firing. 
  • Anterograde degeneration study of the cortical projections of the lateral geniculate and pulvinar nuclei in the tree shrew (Tupaia glis). 
  • Anterograde degeneration study of the superior colliculus in Tupaia glis: evidence for a subdivision between superficial and deep layers. 
  • Apolipoprotein E mimetic peptide CN-105 improves outcome in a murine model of SAH. 
  • Apolipoprotein E-mimetics inhibit neurodegeneration and restore cognitive functions in a transgenic Drosophila model of Alzheimer's disease. 
  • Autophagy protects against aminochrome-induced cell death in substantia nigra-derived cell line. 
  • Benzodiazepines protect hippocampal neurons from degeneration after transient cerebral ischemia: an ultrastructural study. 
  • Biochemical and morphological validation of a rodent model of organophosphorus-induced delayed neuropathy. 
  • Blocking the interaction between apolipoprotein E and Aβ reduces intraneuronal accumulation of Aβ and inhibits synaptic degeneration. 
  • Brain natriuretic peptide improves long-term functional recovery after acute CNS injury in mice. 
  • C-terminal deletion of the atrophin-1 protein results in growth retardation but not neurodegeneration in mice. 
  • CGG repeat-associated translation mediates neurodegeneration in fragile X tremor ataxia syndrome. 
  • COG1410 improves cognitive performance and reduces cortical neuronal loss in the traumatically injured brain. 
  • Calcineurin activation causes retinal ganglion cell degeneration. 
  • Cdc2 phosphorylation of nucleolin demarcates mitotic stages and Alzheimer's disease pathology. 
  • Cell death in age-related macular degeneration. 
  • Cellular regulation of the benzodiazepine/GABA receptor: arachidonic acid, calcium, and cerebral ischemia. 
  • Chemokines, neuronal-glial interactions, and central processing of neuropathic pain. 
  • Cognitive deficits and CNS damage after a 4-day binge ethanol exposure in rats. 
  • Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma. 
  • Comparative toxicity of kainic acid and other acidic amino acids toward rat hippocampal neurons. 
  • Cord blood for brain injury. 
  • Creutzfeldt-Jakob disease in a pregnant woman with an implanted dura mater graft. 
  • Critical periods for the role of oxidative stress in the developmental neurotoxicity of chlorpyrifos and terbutaline, alone or in combination. 
  • Cultured motor neurons possess calcium-permeable AMPA/kainate receptors. 
  • Current status of antioxidant therapy for Alzheimer's Disease. 
  • Degeneration of hippocampal CA3 pyramidal cells induced by intraventricular kainic acid. 
  • Degeneration of the central nervous system associated with celiac disease. 
  • Denatured muscle as a nerve conduit: a functional, morphologic, and electrophysiologic evaluation. 
  • Dexamethasone-coated neural probes elicit attenuated inflammatory response and neuronal loss compared to uncoated neural probes. 
  • Disrupted iron homeostasis causes dopaminergic neurodegeneration in mice. 
  • Dysautonomia in Guillain-Barré syndrome with dorsal root ganglioneuropathy, wallerian degeneration, and fatal myocarditis. 
  • Early complement genes are associated with visual system degeneration in multiple sclerosis. 
  • Ectopic synaptogenesis in the mammalian retina caused by rod photoreceptor-specific mutations. 
  • Effects of transient forebrain ischemia in area CA1 of the gerbil hippocampus: an in vitro study. 
  • Efferent projections of the main and the accessory olfactory bulb in the tree shrew (Tupaia glis). 
  • EndothelinA receptor antagonist BSF-208075 causes immune modulation and neuroprotection after stroke in gerbils. 
  • Evolution of neocortex. 
  • Evolution of the primate visual system: anterograde degeneration studies of the tecto-pulvinar system. 
  • Evolution of the pulvinar. 
  • Exposure to mitochondrial genotoxins and dopaminergic neurodegeneration in Caenorhabditis elegans. 
  • Expression of the non-proliferation-specific protein, statin, in grey matter neuroglia of the aging rat brain. 
  • Extracellular ions, hypoxic irreversible loss of function and delayed postischemic neuron degeneration studied in vitro. 
  • Fast spin-echo MR in hippocampal sclerosis: correlation with pathology and surgery. 
  • Fate of the hippocampal mossy fiber projection after destruction of its postsynaptic targets with intraventricular kainic acid. 
  • Fetal and adolescent nicotine administration: effects on CNS serotonergic systems. 
  • Fiber sorting in the fasciculus gracilis of squirrel monkeys. 
  • Gap junctional intercellular communication in hypoxia-ischemia-induced neuronal injury. 
  • Gene-environment interactions: neurodegeneration in non-mammals and mammals. 
  • Glutamate mobilizes [Zn2+] through Ca2+ -dependent reactive oxygen species accumulation. 
  • Glutamic acid decarboxylase-67-positive hippocampal interneurons undergo a permanent reduction in number following kainic acid-induced degeneration of ca3 pyramidal neurons. 
  • HMGB1 acts on microglia Mac1 to mediate chronic neuroinflammation that drives progressive neurodegeneration. 
  • Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration. 
  • Interaction of the polyglutamine protein ataxin-3 with Rad23 regulates toxicity in Drosophila models of Spinocerebellar Ataxia Type 3. 
  • Ipsilateral subcortical atrophy associated with temporal lobectomy. 
  • Ischemic stroke: "acidotoxicity" is a perpetrator. 
  • Isoflurane-induced neuronal degeneration: an evaluation in organotypic hippocampal slice cultures. 
  • Kainic acid seizures and neuronal cell death: insights from studies of selective lesions and drugs. 
  • Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration. 
  • Long-term status of pyramidal cell axon collaterals and apical dendritic spines in denervated cortex. 
  • Loss of tau elicits axonal degeneration in a mouse model of Alzheimer's disease. 
  • Lupus-related myelopathy: report of three cases and review of the literature. 
  • Molecular Features Underlying Neurodegeneration Identified through In Vitro Modeling of Genetically Diverse Parkinson's Disease Patients. 
  • Nervous system defects of AnkyrinB (-/-) mice suggest functional overlap between the cell adhesion molecule L1 and 440-kD AnkyrinB in premyelinated axons. 
  • Neuroinflammation and α-synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of Parkinson's disease. 
  • Neuronal integrity and complement control synaptic material clearance by microglia after CNS injury. 
  • New in vitro model of traumatic neuronal injury: evaluation of secondary injury and glutamate receptor-mediated neurotoxicity. 
  • Noninvasively induced degeneration of neocortical pyramidal neurons in vivo: selective targeting by laser activation of retrogradely transported photolytic chromophore. 
  • On the relation between seizures and brain lesions after intracerebroventricular kainic acid. 
  • Optical and pharmacological tools to investigate the role of mitochondria during oxidative stress and neurodegeneration. 
  • Oxidative damage is a potential cause of cone cell death in retinitis pigmentosa. 
  • Parallels in the visual afferent projections of the thalamus in the hedgehog (Paraechinus hypomelas) and the turtle (Pseudemys scripta). 
  • Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity. 
  • Peripheral neuropathy in mouse hereditary diabetes mellitus. II. Ultrastructural correlates of degenerative and regenerative changes. 
  • Phenylmethylsulfonyl fluoride alters sensitivity to organophosphorus-induced delayed neurotoxicity in developing animals. 
  • Photoreceptor synapses degenerate early in experimental choroidal neovascularization. 
  • Pik3c3 deletion in pyramidal neurons results in loss of synapses, extensive gliosis and progressive neurodegeneration. 
  • Polyglutamine domains are substrates of tissue transglutaminase: does transglutaminase play a role in expanded CAG/poly-Q neurodegenerative diseases? 
  • Porcine Hemagglutinating Encephalomyelitis Virus Activation of the Integrin α5β1-FAK-Cofilin Pathway Causes Cytoskeletal Rearrangement To Promote Its Invasion of N2a Cells. 
  • Protective effects of mossy fiber lesions against kainic acid-induced seizures and neuronal degeneration. 
  • Quantitative 1H magnetic resonance spectroscopic imaging determines therapeutic immunization efficacy in an animal model of Parkinson's disease. 
  • Quantitative morphological assessment reveals neuronal and glial deficits in hippocampus after a brief subtoxic exposure to chlorpyrifos in neonatal rats. 
  • ROS effects on neurodegeneration in Alzheimer's disease and related disorders: on environmental stresses of ionizing radiation. 
  • Rapid decline of GABAA receptor subunit mRNA expression in hippocampus following transient cerebral ischemia in the gerbil. 
  • Rats! Hyperglycemia protects against glaucoma! 
  • Respiratory pathology in the Optn-/- mouse model of Amyotrophic Lateral Sclerosis. 
  • Retinal Ganglion Cells With a Glaucoma OPTN(E50K) Mutation Exhibit Neurodegenerative Phenotypes when Derived from Three-Dimensional Retinal Organoids. 
  • Retinal neurodegeneration on optical coherence tomography and cerebral atrophy. 
  • Retinal thinning in amyotrophic lateral sclerosis patients without ophthalmic disease. 
  • Selective neocortical and thalamic cell death in the gerbil after transient ischemia. 
  • Selective reinnervation of hippocampal area CA1 and the fascia dentata after destruction of CA3-CA4 afferents with kainic acid. 
  • Senataxin mutations elicit motor neuron degeneration phenotypes and yield TDP-43 mislocalization in ALS4 mice and human patients. 
  • Sex-dependent effect of APOE on Alzheimer's disease and other age-related neurodegenerative disorders. 
  • Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury. 
  • Synaptic organization and acetylcholine sensitivity of multiply innervated autonomic ganglion cells. 
  • Tau-knockout mice show reduced GSK3-induced hippocampal degeneration and learning deficits. 
  • Thalamo-cortical projections in the tree shrew (Tupaia glis). 
  • Thalamotelencephalic projections in the turtle (Pseudemys scripta). 
  • The Aryl Hydrocarbon Receptor: A Mediator and Potential Therapeutic Target for Ocular and Non-Ocular Neurodegenerative Diseases. 
  • The bushy cells in the anteroventral cochlear nucleus of the cat. A study with the electron microscope. 
  • The genomic, biochemical, and cellular responses of the retina in inherited photoreceptor degenerations and prospects for the treatment of these disorders. 
  • The impact of chronic blood-brain barrier breach on intracortical electrode function. 
  • The novel apolipoprotein E-based peptide COG1410 improves sensorimotor performance and reduces injury magnitude following cortical contusion injury. 
  • The organization of the lateral posterior nucleus in neonatal golden hamsters. 
  • The unlikely partnership between LRRK2 and α-synuclein in Parkinson's disease. 
  • The use of locomotor activity as a behavioral screen for neuronal damage following transient forebrain ischemia in gerbils. 
  • Tumor necrosis factor promotes motor functional recovery in crushed peripheral nerve. 
  • Use of excitatory amino acids to make axon-sparing lesions of hypothalamus. 
  • Visual cortex of the grey squirrel (Sciurus carolinensis): architectonic subdivisions and connections from the visual thalamus. 
  • Visual event-related potentials in progressive supranuclear palsy, corticobasal degeneration, striatonigral degeneration, and Parkinson's disease. 
  • Visual impairment in an optineurin mouse model of primary open-angle glaucoma. 
• 

  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • James, Michael Lucas, Associate Professor of Anesthesiology, Anesthesiology
  • Liu, Yutao, Adjunct Assistant Professor in the Department of Medicine, Medicine, Medical Genetics