Nerve Regeneration

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  Subject Areas on Research

  • A collagen-based nerve guide conduit for peripheral nerve repair: an electrophysiological study of nerve regeneration in rodents and nonhuman primates. 
  • A deficit in astroglial organization causes the impaired reactive sprouting in human apolipoprotein E4 targeted replacement mice. 
  • A high mitochondrial transport rate characterizes CNS neurons with high axonal regeneration capacity. 
  • A new millenium for spinal cord regeneration: growth-associated genes. 
  • A new nerve guide conduit material composed of a biodegradable poly(phosphoester). 
  • A protein induced during nerve growth (GAP-43) is a major component of growth-cone membranes. 
  • A transcription-dependent switch controls competence of adult neurons for distinct modes of axon growth. 
  • A transcriptional role for C/EBP beta in the neuronal response to axonal injury. 
  • Accuracy of regenerating motor neurons: influence of diffusion in denervated nerve. 
  • Acidic fibroblast growth factor enhances peripheral nerve regeneration in vivo. 
  • Acidic fibroblast growth factor enhances regeneration of processes by postnatal mammalian retinal ganglion cells in culture. 
  • Adult c-Kit(+) progenitor cells are necessary for maintenance and regeneration of olfactory neurons. 
  • Adult human nasal mesenchymal-like stem cells restore cochlear spiral ganglion neurons after experimental lesion. 
  • Advances in bioengineered conduits for peripheral nerve regeneration. 
  • Agarose gel stiffness determines rate of DRG neurite extension in 3D cultures. 
  • An 8.5-kb segment of the PMP22 promoter responds to loss of axon signals during Wallerian degeneration, but does not respond to specific axonal signals during nerve regeneration. 
  • An Eclectic Review of the History of Peripheral Nerve Surgery. 
  • An apolipoprotein E-mimetic stimulates axonal regeneration and remyelination after peripheral nerve injury. 
  • An in vitro neurite-promoting antigen functions in axonal regeneration in vivo. 
  • An in vivo model to quantify motor and sensory peripheral nerve regeneration using bioresorbable nerve guide tubes. 
  • Analysis of complex matrices functional in neuronal process extension using monoclonal antibodies in vitro and in vivo. 
  • Analyzing somatosensory axon projections with the sensory neuron-specific Advillin gene. 
  • Antibodies against the NG2 proteoglycan promote the regeneration of sensory axons within the dorsal columns of the spinal cord. 
  • Apolipoprotein E and brain injury: implications for children. 
  • Apolipoprotein E epsilon4 allele and outcomes of traumatic spinal cord injury. 
  • At the interface: convergence of neural regeneration and neural prostheses for restoration of function. 
  • Autoradiographic evidence that septohippocampal fibers reinnervate fascia dentata denervated by entorhinal lesion during development. 
  • Axon regeneration pathways identified by systematic genetic screening in C. elegans. 
  • Axonal plasticity elicits long-term changes in oligodendroglia and myelinated fibers. 
  • Axotomized mouse retinal ganglion cells containing melanopsin show enhanced survival, but not enhanced axon regrowth into a peripheral nerve graft. 
  • Axotomy-induced regulation of c-Jun expression in regenerating rat retinal ganglion cells. 
  • Brain natriuretic peptide improves long-term functional recovery after acute CNS injury in mice. 
  • Changes in axonally transported proteins during axon regeneration in toad retinal ganglion cells. 
  • Changes in the expression of transcription factors ATF-2 and Fra-2 after axotomy and during regeneration in rat retinal ganglion cells. 
  • Characteristics of cat skeletal muscles grafted with intact nerves or with anastomosed nerves. 
  • Characteristics of growth-associated polypeptides in regenerating toad retinal ganglion cell axons. 
  • Characterization of a composite injury model of severe lower limb bone and nerve trauma. 
  • Ciliary neurotrophic factor is an axogenesis factor for retinal ganglion cells. 
  • Combining topographical and genetic cues to promote neuronal fate specification in stem cells. 
  • Competitive and non-competitive re-innervation of mammalian sympathetic neurones by native and foreign fibres. 
  • Control of axonal growth and regeneration of sensory neurons by the p110delta PI 3-kinase. 
  • Degenerative and regenerative changes in central projections of glossopharyngeal and vagal sensory neurons after peripheral axotomy in cats: a structural basis for central reorganization of arterial chemoreflex pathways. 
  • Denatured muscle as a nerve conduit: a functional, morphologic, and electrophysiologic evaluation. 
  • Developmental change in the access to olfactory memories. 
  • Developmentally regulated changes in femoral nerve regeneration in the mouse and rat. 
  • Differences between the effect of anisotropic and isotropic laminin and nerve growth factor presenting scaffolds on nerve regeneration across long peripheral nerve gaps. 
  • Digital sensibility following replantation. 
  • Double-labeling of saphenous nerve neuron pools: a model for determining the accuracy of axon regeneration at the single neuron level. 
  • Doublecortin-Like Kinases Promote Neuronal Survival and Induce Growth Cone Reformation via Distinct Mechanisms. 
  • EMG of reinnervated motor units: a simulation study. 
  • Effect of modulating macrophage phenotype on peripheral nerve repair. 
  • Effect of nerve growth factor on synaptic depression after axotomy. 
  • Electrical stimulation alters protein adsorption and nerve cell interactions with electrically conducting biomaterials. 
  • Elevated synthesis of an axonally transported protein correlates with axon outgrowth in normal and injured pyramidal tracts. 
  • Embryonic cord transplants in peripheral nerve restore skeletal muscle function. 
  • End-to-side nerve repair. A review. 
  • Endoscopic Corneal Neurotization: Technique and Initial Experience. 
  • Entubulation repair with protein additives increases the maximum nerve gap distance successfully bridged with tubular prostheses. 
  • Epidermal denervation and its effects on keratinocytes and Langerhans cells. 
  • Evidence for central reorganization of ventilatory chemoreflex pathways in the cat during regeneration of visceral afferents in the carotid sinus nerve. 
  • Evidence of functional mossy fiber sprouting in hippocampal formation of kainic acid-treated rats. 
  • Examination of a nerve injury-induced, 37 kDa protein: purification and characterization. 
  • Expression of apolipoprotein E during nerve degeneration and regeneration. 
  • Fabrication of poly(phosphoester) nerve guides by immersion precipitation and the control of porosity. 
  • Factors contributing to preferential motor reinnervation in the primate peripheral nervous system. 
  • Factors that influence peripheral nerve regeneration: an electrophysiological study of the monkey median nerve. 
  • Fate of GAP-43 in ascending spinal axons of DRG neurons after peripheral nerve injury: delayed accumulation and correlation with regenerative potential. 
  • Fate of the hippocampal mossy fiber projection after destruction of its postsynaptic targets with intraventricular kainic acid. 
  • Fetal spina bifida repair--current trends and prospects of intrauterine neurosurgery. 
  • Folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation. 
  • Folic acid supplementation enhances repair of the adult central nervous system. 
  • Functional and structural changes in mammalian sympathetic neurones following colchicine application to post-ganglionic nerves. 
  • Functional and structural changes in mammalian sympathetic neurones following interruption of their axons. 
  • Functional effects of lymphotoxin on crushed peripheral nerve. 
  • Functional recordings from awake, behaving rodents through a microchannel based regenerative neural interface. 
  • Functional reorganisation of memory after traumatic brain injury: a study with H(2)(15)0 positron emission tomography. 
  • GAP-43 promoter elements in transgenic zebrafish reveal a difference in signals for axon growth during CNS development and regeneration. 
  • Growth-associated proteins and the curious dichotomies of nerve regeneration. 
  • Human neural stem cell transplants improve motor function in a rat model of Huntington's disease. 
  • Identification of a peripheral nerve neurite growth-promoting activity by development and use of an in vitro bioassay. 
  • Immediate early gene expression in axotomized and regenerating retinal ganglion cells of the adult rat. 
  • Immunoengineering nerve repair. 
  • Impairment of radial-arm maze performance in rats following lesions involving the cholinergic medial pathway: reversal by arecoline and differential effects of muscarinic and nicotinic antagonists. 
  • Improved nerve regeneration through piezoelectric vinylidenefluoride-trifluoroethylene copolymer guidance channels. 
  • In situ gelling hydrogels for conformal repair of spinal cord defects, and local delivery of BDNF after spinal cord injury. 
  • Increased rate of peripheral nerve regeneration using bioresorbable nerve guides and a laminin-containing gel. 
  • Increased spontaneous unit activity and appearance of spontaneous negative potentials in the goldfish tectum during refinement of the optic projection. 
  • Increases in ribosomal RNA within the denervated neuropil of the dentate gyrus during reinnervation: evaluation by in situ hybridization using DNA probes complementary to ribosomal RNA. 
  • Influence of common drugs and related factors on stroke outcome. 
  • Influence of lesion size and location on amphetamine-facilitated recovery of beam-walking in rats. 
  • Influence of terminal nerve branch size on motor neuron regeneration accuracy. 
  • Inhibition of inducible nitric oxide synthase promotes recovery of motor function in rats after sciatic nerve ischemia and reperfusion. 
  • Injuring neurons induces neuronal differentiation in a population of hippocampal precursor cells in culture. 
  • Interaction with CA4-derived fibers accounts for distribution of septohippocampal fibers in rat fascia dentata after entorhinal lesion. 
  • Interleukin-1 beta promotes functional recovery of crushed peripheral nerve. 
  • Intraoperative mapping during repeat awake craniotomy reveals the functional plasticity of adult cortex. 
  • Introduction: peripheral nerve surgery--biology, entrapment, and injuries. 
  • Levator ani denervation and reinnervation 6 months after childbirth. 
  • Long-term status of pyramidal cell axon collaterals and apical dendritic spines in denervated cortex. 
  • Loss and reacquisition of hippocampal synapses after selective destruction of CA3-CA4 afferents with kainic acid. 
  • Manipulations of the mouse femoral nerve influence the accuracy of pathway reinnervation by motor neurons. 
  • Measurement of intraoperative nerve conduction velocities during anterior interosseous nerve decompression. 
  • Mechanisms of nerve capping technique in prevention of painful neuroma formation. 
  • Mechanisms underlying reversal of motor unit activation order in electrically evoked contractions after spinal cord injury. 
  • Mechanistic Insights into Sympathetic Neuronal Regeneration: Multitracer Molecular Imaging of Catecholamine Handling After Cardiac Transplantation. 
  • Merosin promotes neurite growth and Schwann cell migration in vitro and nerve regeneration in vivo: evidence using an antibody to merosin, ARM-1. 
  • Metallothionein in the central nervous system: Roles in protection, regeneration and cognition. 
  • Microchannel-based regenerative scaffold for chronic peripheral nerve interfacing in amputees. 
  • Midgestational sciatic nerve transection in fetal sheep results in absent nerve regeneration and neurogenic muscle atrophy. 
  • Minimally Invasive Corneal Neurotization With Acellular Nerve Allograft: Surgical Technique and Clinical Outcomes. 
  • Modulation of Rho GTPase activity alleviates chondroitin sulfate proteoglycan-dependent inhibition of neurite extension. 
  • Molecular sequelae of topographically guided peripheral nerve repair. 
  • Monkey median nerve repaired by nerve graft or collagen nerve guide tube. 
  • Motor functional and morphological findings following end-to-side neurorrhaphy in the rat model. 
  • Motor neuron regeneration accuracy: balancing trophic influences between pathways and end-organs. 
  • Motor neuron target selectivity and survival after prolonged axotomy. 
  • Motor neurons can preferentially reinnervate cutaneous pathways. 
  • Mutation of a putative protein degradation gene LITAF/SIMPLE in Charcot-Marie-Tooth disease 1C. 
  • N-methyl-D-aspartate receptors strongly regulate postsynaptic activity levels during optic nerve regeneration. 
  • Netrin-1 and peripheral nerve regeneration in the adult rat. 
  • Network level properties of short-term plasticity in the somatosensory system. 
  • Neural circuit repair by low-intensity magnetic stimulation requires cellular magnetoreceptors and specific stimulation patterns. 
  • Neurite outgrowth is enhanced by anti-idiotypic monoclonal antibodies to the ganglioside GM1. 
  • Neurotization of elements of the brachial plexus. 
  • Nogo receptor 1 is expressed by nearly all retinal ganglion cells. 
  • Nontoxic nerve guide tubes support neovascular growth in transected rat optic nerve. 
  • Normal spastin gene dosage is specifically required for axon regeneration. 
  • Overcoming endogenous constraints on neuronal regeneration. 
  • Peripheral nerve regeneration by microbraided poly(L-lactide-co-glycolide) biodegradable polymer fibers. 
  • Peripheral nerve regeneration with entubulation repair: comparison of biodegradeable nerve guides versus polyethylene tubes and the effects of a laminin-containing gel. 
  • Peripheral nerve regeneration with sustained release of poly(phosphoester) microencapsulated nerve growth factor within nerve guide conduits. 
  • Peripheral nerve regeneration: an opinion on channels, scaffolds and anisotropy. 
  • Peripheral nerve repair with collagen conduits. 
  • Peripheral neuropathy in mouse hereditary diabetes mellitus. II. Ultrastructural correlates of degenerative and regenerative changes. 
  • Persistent innervation of mammalian sympathetic neurones by native and foreign fibres. 
  • Phosphorylated microtubule associated protein (MAP1B-Phos) in the retina during regeneration of the fish optic nerve. 
  • Physiologic status of regenerated hair cells in the avian inner ear following aminoglycoside ototoxicity. 
  • Physiological and ultrastructural observations on regenerated carotid sinus nerves after removal of the carotid bodies in cats. 
  • Platelet-rich plasma and peripheral nerve regeneration: a potential contraindication to its use after tumor excision. 
  • Point sources of Schwann cells result in growth into a nerve entubulation repair site in the absence of axons: effects of freeze-thawing. 
  • Polyethylene glycol fusion repair prevents reinnervation accuracy in rat peripheral nerve. 
  • Polyphosphoester microspheres for sustained release of biologically active nerve growth factor. 
  • Posttraumatic abducens to oculomotor nerve misdirection. 
  • Preferential motor reinnervation in the mouse: comparison of femoral nerve repair using a fibrin sealant or suture. 
  • Preliminary report of a genetic basis for cognitive decline after cardiac operations. The Neurologic Outcome Research Group of the Duke Heart Center. 
  • Properties of medial gastrocnemius motor units and muscle fibers reinnervated by embryonic ventral spinal cord cells. 
  • Protective effect of 21-aminosteroid pretreatment in peripheral nerve low-load crush injury in mature and immature rats. 
  • Re-innervation of ganglia transplanted to the neck from different levels of the guinea-pig sympathetic chain. 
  • Re-innervation of guinea-pig superior cervical ganglion cells by preganglionic fibres arising from different levels of the spinal cord. 
  • Regenerative scaffold electrodes for peripheral nerve interfacing. 
  • Regional cardiac sympathetic innervation early and late after transmyocardial laser revascularization. 
  • Reinnervation accuracy of the rat femoral nerve by motor and sensory neurons. 
  • Retinal ganglion cell body response to repeated axotomy in the regenerating visual system on newt (Notophthalmus viridescens). 
  • Retinal ganglion cells and axons survive optic nerve transection. 
  • Reverse end-to-side neurotization. 
  • Reversing nerve-graft polarity in a rat model: the effect on function. 
  • Rho GTPase/Rho kinase inhibition as a novel target for the treatment of glaucoma. 
  • RhoA activity and post-ischemic inflammation in an experimental model of adult rodent anterior ischemic optic neuropathy. 
  • Role of ornithine decarboxylase and the polyamines in nervous system development: a review. 
  • Schwann cell influence on motor neuron regeneration accuracy. 
  • Selective reinnervation of hippocampal area CA1 and the fascia dentata after destruction of CA3-CA4 afferents with kainic acid. 
  • Sharp chest pains occurring during right ventricular biopsy in a patient 9 years after cardiac transplant. 
  • Single-fiber EMG demonstrates reinnervation dynamics after nerve injury. 
  • Specific connections between nerve cells. 
  • Specificity of initial synaptic contacts made on guinea-pig superior cervical ganglion cells during regeneration of the cervical sympathetic trunk. 
  • Spinal axon regeneration evoked by replacing two growth cone proteins in adult neurons. 
  • Spontaneous retinal activity is tonic and does not drive tectal activity during activity-dependent refinement in regeneration. 
  • Sprouting of noradrenergic fibers in hippocampus after medial septal lesions: contributions of the central and peripheral nervous systems. 
  • Stabilizing electrode-host interfaces: a tissue engineering approach. 
  • Suppressive effects of halothane on reactive synaptogenesis in the dentate gyrus of rats. 
  • Synaptic sites on reinnervated nerve cells visualized at two different times in living mice. 
  • Synthesis and characterization of polypyrrole-hyaluronic acid composite biomaterials for tissue engineering applications. 
  • Tenascin-C expression in dystrophin-related muscular dystrophy. 
  • The Mammalian-Specific Protein Armcx1 Regulates Mitochondrial Transport during Axon Regeneration. 
  • The c-Jun transcription factor--bipotential mediator of neuronal death, survival and regeneration. 
  • The development and recovery of motor function in spinal cats. I. The infant lesion effect. 
  • The development and recovery of motor function in spinal cats. II. Pharmacological enhancement of recovery. 
  • The effects of exogenous nitric oxide donor on motor functional recovery of reperfused peripheral nerve. 
  • The effects of post-ganglionic axotomy on selective synaptic connexions in the superior cervical ganglion of the guinea-pig. 
  • The fetal spinal cord does not regenerate after in utero transection in a large mammalian model. 
  • The influence of physical structure and charge on neurite extension in a 3D hydrogel scaffold. 
  • The normal organization of the lateral posterior nucleus in the golden hamster and its reorganization after neonatal superior colliculus lesions. 
  • The organization of afferents to the lateral posterior nucleus in the golden hamster after different combinations of neonatal lesions. 
  • The organization of the lateral posterior nucleus in neonatal golden hamsters. 
  • The organization of the lateral posterior nucleus of the golden hamster after neonatal superior colliculus lesions. 
  • The phosphorylated isoform of microtubule associated protein 1B (MAP1B) is expressed in the visual system of the tench (Tinca tinca, L) during optic nerve regeneration. 
  • The relationship of functional return to varying methods of nerve repair. 
  • The role of aligned polymer fiber-based constructs in the bridging of long peripheral nerve gaps. 
  • The specificity of motor neurone regeneration (preferential reinnervation). 
  • The use of cultured Schwann cells in nerve repair in a rabbit hind-limb model. 
  • Thin-film enhanced nerve guidance channels for peripheral nerve repair. 
  • Topography, cell response, and nerve regeneration. 
  • Toward Functional Restoration of the Central Nervous System: A Review of Translational Neuroscience Principles. 
  • Toward a convergence of regenerative medicine, rehabilitation, and neuroprosthetics. 
  • Tumor necrosis factor promotes motor functional recovery in crushed peripheral nerve. 
  • Use of Processed Nerve Allografts to Repair Nerve Injuries Greater Than 25 mm in the Hand. 
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  Keywords of People

  • Choi, Steven Sok, Associate Professor of Medicine, Medicine, Gastroenterology
  • James, Michael Lucas, Associate Professor of Anesthesiology, Anesthesiology, Neuroanesthesia
  • Stinnett, Sandra Sue, Associate Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics
  • Velkey, John Matthew, Assistant Professor of the Practice of Medical Education in the Department of Cell Biology, Cell Biology